Hub : Genes

Neurod2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative TSS	XM_039086671.1	0.08	0.07	1.7e-04	0.01	0.01	-0	-0	5.9e-02	5.7e-02	6.5e-01	4.3e-01
2	PL	alternative TSS	NM_019326.2	0.07	0.07	1.4e-04	0.01	0.01	-0	0	7.0e-02	3.2e-02	4.7e-01	3.5e-01
3	PL	isoform ratio	NM_019326.2	0.05	0.06	2.6e-03	0.02	0.01	0.01	0.01	1.8e-03	8.4e-03	5.1e-02	1.3e-02
4	PL	isoform ratio	XM_039086671.1	0.04	0.05	3.2e-03	0.02	0.01	0	0.01	2.3e-03	1.5e-02	7.7e-02	1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.7	3.0	3.6	1.9	-1.9	-1.5	1.5
Area under the delay curve	0.5	0.6	0.9	1.0	-1.0	-0.5	0.5
BMI with tail	3.2	11.2	12.5	-3.2	3.1	3.5	-3.5
BMI without tail	2.0	6.2	6.6	-2.6	2.5	2.4	-2.4
Body weight	8.6	37.6	41.2	-6.4	6.4	5.9	-5.9
Weight adjusted by age	0.2	0.4	0.4	-0.5	0.5	0.7	-0.7
Bone surface	0.0	0.1	0.1	-0.2	0.2	0.4	-0.4
Bone volume	0.0	0.1	0.1	0.0	-0.1	0.3	-0.3
Breakpoint value in progressive ratio session	0.8	0.9	1.9	-1.3	1.4	0.1	-0.1
Number of licking bursts	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4
Context. condit. distance diff. score	0.3	0.3	0.4	-0.6	0.6	0.5	-0.5
Locomotion velocity, session 1	0.9	1.0	1.2	-1.1	1.1	0.9	-0.9
Locomotion distance, session 1	4.2	5.3	6.2	-2.5	2.5	2.1	-2.1
Locomotion velocity, session 2	0.2	0.2	0.5	-0.7	0.7	0.1	-0.1
Locomotion distance, session 2	0.8	1.1	1.5	-1.2	1.2	0.9	-0.9
Locomotion velocity, session 3	0.1	0.1	0.1	-0.1	0.1	-0.4	0.4
Locomotion distance, session 3	0.4	0.4	0.5	-0.7	0.7	0.6	-0.6
Stereotopy head waving bouts, day 3	3.8	4.4	4.9	2.2	-2.2	-2.0	2.0
Stereotopy head waving duration, day 3	0.4	0.5	0.7	0.8	-0.8	-0.5	0.5
Locomotion velocity, session 7	1.7	1.8	2.1	-1.3	1.2	1.5	-1.5
Locomotion distance, session 7	0.4	0.5	0.7	-0.6	0.6	0.8	-0.8
Stereotopy head waving bouts, day 7	0.9	1.0	1.6	1.3	-1.3	-0.6	0.6
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.8	-0.8	-0.4	0.4
Locomotion velocity, session 8	6.9	8.2	9.2	-3.0	3.0	2.7	-2.7
Locomotion distance, session 8	1.7	2.4	2.7	-1.7	1.6	1.4	-1.4
Degree of sensitization distance	0.5	0.5	0.5	-0.6	0.7	0.7	-0.7
Degree of sensitization stereotypy	0.9	1.0	1.8	1.3	-1.4	-0.5	0.5
Conditioned locomotion	0.5	0.5	0.7	0.6	-0.6	-0.8	0.8
Cocaine response after cond. corrected	0.6	0.7	1.5	1.1	-1.2	0.2	-0.2
Cocaine response after cond. not corrected	0.8	0.9	1.9	1.3	-1.4	0.3	-0.3
Cocaine response before conditioning	0.1	0.2	0.3	0.5	-0.6	-0.2	0.2
Saline control response	0.6	0.8	1.4	-0.5	0.4	1.2	-1.2
Bone: connectivity density	2.9	4.5	5.1	2.3	-2.3	-2.0	2.0
Bone: cortical apparent density	8.3	11.4	12.5	3.2	-3.2	-3.5	3.5
Bone: cortical area	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3
Bone: cortical porosity	0.2	0.2	0.4	0.6	-0.6	0.1	-0.1
Bone: cortical porosity	0.2	0.2	0.3	0.4	-0.5	0.5	-0.5
Bone: cortical thickness	1.6	2.6	3.1	1.7	-1.7	-1.5	1.5
Bone: cortical thickness	5.4	6.3	6.6	2.6	-2.6	-2.5	2.5
Bone: cortical tissue density	8.3	11.4	12.4	3.2	-3.2	-3.5	3.5
Condit. Reinf. active minus inactive responses	1.3	1.5	2.0	1.0	-1.0	-1.4	1.4
Condit. Reinf. active-inactive response ratio	2.2	2.4	3.1	1.3	-1.2	-1.8	1.8
Condit. Reinf. active responses	1.3	1.6	1.9	1.1	-1.1	-1.4	1.4
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	-0.5	-0.0	0.0
Incentive salience index mean	2.2	2.7	3.2	1.5	-1.5	-1.8	1.8
Condit. Reinf. lever presses	1.2	1.7	1.8	1.3	-1.3	-1.3	1.3
Condit. Reinf. active minus inactive responses	0.5	0.7	0.7	0.8	-0.8	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	0.6	-0.6	-0.6	0.6
Condit. Reinf. active responses	0.6	0.9	0.9	0.9	-1.0	-0.9	0.9
Condit. Reinf. inactive responses	0.9	1.2	1.4	1.2	-1.2	-1.0	1.0
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2
Condit. Reinf. lever reinforcers received	0.9	1.2	1.3	1.0	-1.0	-1.2	1.2
Conditioned reinforcement - actives	0.1	0.2	0.3	0.6	-0.6	-0.2	0.2
Conditioned reinforcement - inactives	0.2	0.2	0.4	0.3	-0.2	-0.6	0.6
Conditioned locomotion	0.7	0.9	1.4	1.2	-1.2	-0.7	0.7
Patch foraging indifference point 0 sec	2.0	3.7	4.2	1.8	-1.8	-2.1	2.1
Patch foraging indifference point AUC	0.0	0.0	0.1	0.0	-0.0	0.3	-0.3
Delay disc. indifference point, 0s delay	2.2	2.4	2.5	1.6	-1.6	-1.5	1.5
Delay disc. indifference point, 16s delay	0.9	1.0	1.2	1.1	-1.0	-1.0	1.0
Delay disc. indifference point, 2s delay	0.9	1.0	1.7	1.2	-1.3	-0.6	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3
Delay disc. indifference point, 4s delay	0.7	0.8	0.9	0.9	-0.9	-0.8	0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.6	-0.6	-0.2	0.2
Indifference point function ln k	0.1	0.1	0.2	0.3	-0.2	-0.4	0.4
Indifference point function log k	0.1	0.1	0.2	0.3	-0.2	-0.4	0.4
Patch foraging total patch changes 0 sec	1.3	2.5	2.9	1.5	-1.4	-1.7	1.7
Patch foraging total patch changes 12 sec	3.9	5.1	5.8	2.4	-2.4	-2.1	2.1
Patch foraging total patch changes 18 sec	0.3	0.5	0.5	0.7	-0.7	-0.7	0.7
Patch foraging total patch changes 24 sec	1.1	1.8	2.6	1.6	-1.6	-1.0	1.0
Patch foraging total patch changes 6 sec	1.7	2.6	2.8	1.5	-1.5	-1.7	1.7
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.2	-0.2	-0.4	0.4
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.2	-0.1	-0.3	0.3
Patch foraging water rate 12 sec	0.1	0.1	0.2	-0.5	0.5	0.0	-0.0
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.7	-0.7	-0.4	0.4
Patch foraging water rate 24 sec	0.3	0.5	0.6	0.6	-0.6	-0.8	0.8
Patch foraging water rate 6 sec	1.0	1.5	1.6	1.2	-1.2	-1.3	1.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.1	0.2	-0.6	0.6
Distance traveled before self-admin	0.2	0.2	0.4	-0.6	0.6	-0.2	0.2
Distance traveled after self-admin	0.8	1.0	1.6	-1.3	1.3	0.6	-0.6
Extensor digitorum longus weight	8.5	33.4	36.5	-6.0	6.0	5.5	-5.5
Bone: elastic displacement	0.0	0.0	0.0	0.2	-0.2	-0.0	0.0
Bone: elastic work	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Bone: endosteal estimation	2.9	6.5	6.6	-2.6	2.5	2.5	-2.5
Bone: endosteal perimeter	2.1	4.4	5.5	-2.3	2.3	1.9	-1.9
Epididymis fat weight	0.3	1.0	1.1	-1.0	1.0	1.1	-1.1
Delta time in closed arm before/after self-admin	5.0	4.6	4.6	-2.1	2.1	2.2	-2.2
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	-0.6	0.6	0.2	-0.2
Delay discount exponential model param	0.3	0.3	0.6	-0.7	0.7	0.3	-0.3
Extinction: sum of active levers before priming	1.4	1.5	1.9	-1.1	1.1	1.4	-1.4
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1
Bone: final force	0.3	0.5	0.9	0.9	-1.0	-0.2	0.2
Bone: final moment	0.2	0.3	0.7	0.8	-0.8	-0.0	0.0
Food consumed during 24 hour testing period	1.0	1.3	1.4	-1.1	1.1	1.2	-1.2
Glucose	0.3	0.5	0.9	0.3	-0.4	0.9	-0.9
Heart weight	3.1	4.9	6.1	-2.5	2.5	1.9	-1.9
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.6	0.7	0.3	-0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.5	0.5	0.0	-0.0
Intermittent access intake escalation	0.1	0.1	0.2	-0.5	0.5	0.1	-0.1
Intermittent access intake escalation 2	0.5	0.6	0.8	-0.9	0.9	0.6	-0.6
Intermitt. access day 1 inactive lever presses	0.3	1.2	1.8	0.8	-0.8	-1.4	1.4
Intermitt. access day 15 inactive lever presses	1.0	2.1	2.2	1.4	-1.4	-1.5	1.5
Intermitt. access escalation Index	1.4	2.0	2.6	-1.2	1.2	1.6	-1.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.0	0.0	-0.2	0.2
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.5	0.5	-0.0	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.0	0.0	-0.4	0.4
Intermittent access total infusions	0.1	0.1	0.1	-0.3	0.3	-0.2	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.3	-0.3	-0.5	0.5
Intermittent access day 15 total locomotion	0.2	0.4	0.4	0.6	-0.6	-0.6	0.6
Intermittent access total locomotion	1.1	1.3	1.3	1.1	-1.1	-1.1	1.1
Intermittent access standard deviation	0.6	1.2	2.0	0.6	-0.5	-1.4	1.4
Left kidney weight	0.5	2.4	4.1	-2.0	2.0	0.9	-0.9
Right kidney weight	0.1	0.3	0.5	-0.7	0.7	0.2	-0.2
Cocaine induced anxiety	3.6	5.1	5.5	-2.3	2.3	2.2	-2.2
Post-drug Anxiety	1.1	1.2	1.2	-1.1	1.1	1.1	-1.1
Baseline Anxiety	2.4	2.7	3.9	2.0	-2.0	-1.3	1.3
Tail length	0.7	2.6	4.6	-2.1	2.1	0.9	-0.9
Length with tail	3.5	15.0	20.6	-4.5	4.5	3.1	-3.1
Length without tail	3.6	11.7	13.0	-3.6	3.6	3.2	-3.2
Times rat made contact with spout	0.6	0.7	1.1	1.0	-1.0	-0.6	0.6
Lifetime Intake	0.1	0.1	0.2	-0.1	0.2	-0.4	0.4
Liver weight, left	0.4	0.6	0.7	-0.7	0.7	0.8	-0.8
Liver weight, right	0.5	0.9	1.0	0.9	-0.9	-1.0	1.0
Locomotor activity	0.1	0.2	0.5	0.6	-0.7	-0.1	0.1
Locomotor testing distance	1.6	2.8	4.0	2.0	-2.0	-1.3	1.3
Locomotor testing rearing	5.1	10.4	10.4	3.2	-3.2	-3.2	3.2
Locomotion in novel chamber	4.6	5.9	6.3	2.5	-2.5	-2.3	2.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.3	-0.5	0.5	0.6	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.4	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.6	0.7	0.9	1.0	-0.9	-0.7	0.7
Bouts of movement, locomotor time 1	0.5	0.6	0.6	-0.8	0.8	0.7	-0.7
Total resting periods, locomotor time 1	1.1	1.2	1.2	-1.1	1.1	1.1	-1.1
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Vertical activity count, locomotor time 1	0.3	0.7	1.0	-0.7	0.6	1.0	-1.0
Time >=10cm from walls, locomotor time 2	0.7	1.1	1.7	1.3	-1.3	-0.7	0.7
Bouts of movement, locomotor time 2	0.5	0.9	1.3	0.7	-0.6	-1.1	1.1
Total resting periods, locomotor time 2	0.3	0.6	1.0	0.4	-0.4	-1.0	1.0
Rest time, locomotor task time 2	0.8	1.1	1.3	-1.1	1.1	0.9	-0.9
Distance moved, locomotor task time 2	0.1	0.2	0.3	-0.2	0.2	0.6	-0.6
Vertical activity count, locomotor time 2	0.4	0.5	0.8	-0.5	0.5	0.9	-0.9
Light reinforcement 1	1.3	3.2	3.3	1.8	-1.8	-1.8	1.8
Light reinforcement 2	0.1	0.2	0.4	0.5	-0.6	-0.1	0.1
Bone: marrow area	2.8	6.0	6.2	-2.5	2.5	2.4	-2.4
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.1	-0.0	0.0
Bone: maximum force	0.1	0.2	0.4	-0.3	0.2	0.6	-0.6
Bone: maximum moment	0.2	0.3	0.5	-0.4	0.3	0.7	-0.7
Mean time between licks in bursts	1.1	2.6	2.9	-1.7	1.7	1.5	-1.5
Mean num. licks in bursts	0.2	0.3	0.5	0.4	-0.3	-0.7	0.7
Cd content in liver	1.3	1.4	1.9	-1.4	1.4	1.0	-1.0
Co content in liver	1.0	1.2	2.0	-1.4	1.4	0.7	-0.7
Cu content in liver	0.2	0.3	0.4	-0.4	0.4	-0.6	0.6
Fe content in liver	2.6	3.2	3.3	-1.8	1.8	1.8	-1.8
K content in liver	0.9	0.9	1.3	0.7	-0.6	-1.1	1.1
Mg content in liver	1.7	1.8	2.5	1.1	-1.0	-1.6	1.6
Mn content in liver	2.0	2.2	3.4	1.0	-0.9	-1.9	1.9
Na content in liver	0.1	0.1	0.2	0.1	-0.1	0.4	-0.4
Rb content in liver	1.9	2.2	2.2	1.5	-1.5	-1.5	1.5
Se content in liver	7.7	9.1	11.1	2.7	-2.6	-3.3	3.3
Sr content in liver	0.3	0.3	0.4	-0.4	0.5	-0.6	0.6
Zn content in liver	3.5	3.8	4.7	1.7	-1.7	-2.2	2.2
Bone: minimum diameter	0.8	1.5	1.6	-1.3	1.2	1.2	-1.2
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.0	-0.0	0.6	-0.6
Time in novel zone, hab. session 1	1.5	1.5	1.6	1.3	-1.2	-1.2	1.2
Total zone transitions, hab. session 1	1.8	2.5	3.3	-1.8	1.8	1.3	-1.3
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.8	-0.9	0.9	0.3	-0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	-0.5	-0.1	0.1
Time in novel zone, hab. session 2	0.3	0.3	0.4	0.5	-0.4	-0.7	0.7
Total zone transitions, hab. session 2	1.2	1.5	1.7	-1.2	1.2	1.3	-1.3
Total locomotion distance, hab. session 2	0.5	0.6	0.8	-0.7	0.7	0.9	-0.9
Locomotion velocity, hab. session 2	0.8	1.1	1.1	-1.0	1.0	1.1	-1.1
Novel to familiar place preference ratio	0.5	0.5	0.8	-0.9	0.9	0.5	-0.5
Novelty place preference	0.2	0.2	0.4	-0.6	0.6	0.2	-0.2
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1
Total zone transitions, NPP test	1.1	1.6	1.9	-1.1	1.1	1.4	-1.4
Total locomotion distance, NPP test	0.2	0.3	0.5	-0.3	0.3	0.7	-0.7
Locomotion velocity, NPP test	0.5	0.7	0.8	-0.9	0.8	0.8	-0.8
Intraocular pressure	2.0	2.8	2.9	-1.7	1.7	1.7	-1.7
Delta distance traveled before/after self-admin	0.9	0.9	1.0	-0.9	0.9	1.0	-1.0
Delta ambulatory time before/after self-admin	1.1	1.3	2.0	-0.8	0.8	1.4	-1.4
Parametrial fat weight	0.1	0.3	0.4	0.6	-0.6	-0.4	0.4
Pavlov. Cond. lever latency	1.4	1.8	2.5	-1.5	1.6	1.1	-1.1
Pavlov. Cond. magazine entry latency	8.6	11.1	12.5	3.5	-3.5	-3.1	3.1
Pavlov. Cond. change in total contacts	11.3	12.0	12.3	3.5	-3.5	-3.4	3.4
Pavlov. Cond. index score	7.0	8.8	10.8	3.2	-3.3	-2.7	2.7
Pavlov. Cond. latency score	5.1	6.4	8.2	2.8	-2.9	-2.2	2.2
Pavlov. Cond. lever contacts	2.0	2.3	3.1	1.7	-1.8	-1.3	1.3
Pavlov. Cond. magazine entry number	12.9	16.2	18.8	-4.3	4.3	3.7	-3.7
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.3	-1.1	1.1	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	8.6	10.7	12.7	3.5	-3.6	-3.0	3.0
Pavlov. Cond. response bias	9.7	12.0	13.5	3.7	-3.7	-3.2	3.2
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.5	0.6	0.3	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.3	0.3	0.6	-0.6
Pavlov. Cond. change in total contacts	0.6	0.9	1.1	0.9	-0.9	-1.1	1.1
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.3	0.1	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	-0.2	0.1	-0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.6	-0.6	-0.2	0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.4	-1.1	1.2	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.1	0.2	-0.2
Pavlov. Cond. response bias	0.3	0.5	0.8	0.8	-0.9	-0.5	0.5
Time in closed arm before self-admin	2.8	3.6	4.1	1.8	-1.7	-2.0	2.0
Time in closed arm after self-admin	0.1	0.1	0.1	-0.2	0.2	-0.4	0.4
Time in open arm before self-admin	2.2	2.4	3.1	-1.8	1.8	1.3	-1.3
Time in open arm after self-admin	0.4	0.5	0.5	-0.7	0.7	0.7	-0.7
Bone: periosteal estimation	0.5	1.0	1.1	-1.0	0.9	1.1	-1.1
Bone: periosteal perimeter	1.5	2.6	2.6	-1.6	1.6	1.6	-1.6
Bone: post-yield work	1.1	1.6	1.6	-1.3	1.2	1.2	-1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	-0.4	-0.2	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.4	-0.4	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.2	-0.2	-0.5	0.5
Progressive ratio test 2 active lever presses	0.6	0.7	0.9	0.7	-0.7	-1.0	1.0
Progressive ratio test 2 breakpoint	0.7	0.8	1.0	0.8	-0.8	-1.0	1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.1	0.1	-0.4	0.4
Incentive Sensitization - Responses	0.9	1.3	1.6	1.0	-1.0	-1.3	1.3
Incentive Sensitization - Breakpoint	0.9	1.1	1.5	0.9	-0.9	-1.2	1.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2
Progressive ratio	0.0	0.0	0.0	-0.2	0.2	-0.2	0.2
Food seeking constrained by brief footshock	0.3	0.4	0.4	0.6	-0.7	-0.6	0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.5	-0.6	-0.1	0.1
Retroperitoneal fat weight	0.1	0.3	0.4	0.5	-0.5	-0.6	0.6
Reaction time number correct	0.9	1.8	1.9	-1.4	1.4	1.3	-1.3
Reaction time mean minus median	0.1	0.2	0.4	-0.3	0.3	0.6	-0.6
Reaction time mean minus median AUC	0.0	0.1	0.2	0.4	-0.4	0.3	-0.3
Reaction time num false alarms	0.2	0.2	0.4	0.6	-0.6	-0.3	0.3
Reaction time num false alarms AUC	0.1	0.1	0.2	0.4	-0.4	-0.1	0.1
Reaction time trials correct on left	0.9	1.8	1.9	-1.4	1.4	1.3	-1.3
Reaction time trials on left	0.9	1.7	1.8	-1.4	1.3	1.2	-1.2
Reaction time mean	0.4	0.6	0.8	0.6	-0.6	-0.9	0.9
Reaction time mean AUC	0.3	0.5	0.7	0.6	-0.5	-0.9	0.9
Median of all reaction times	1.2	1.7	2.2	1.1	-1.1	-1.5	1.5
Reaction time omissions	0.3	0.4	0.5	0.7	-0.7	-0.6	0.6
Reaction time false alarm rate	0.7	0.9	1.3	1.1	-1.1	-0.8	0.8
Reaction time premature initiation rate	0.1	0.2	0.2	0.4	-0.4	-0.5	0.5
Reaction time premature initiations	0.2	0.3	0.3	-0.6	0.6	0.5	-0.5
Std. dev. reaction times	0.0	0.0	0.0	0.2	-0.2	-0.0	0.0
Reaction time trials completed	0.9	1.7	1.8	-1.4	1.3	1.2	-1.2
Reaction time trials AUC	0.8	1.4	1.5	-1.2	1.2	1.2	-1.2
Run reversals in cocaine runway, females	1.2	1.2	1.4	-1.1	1.2	1.0	-1.0
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.5	-0.5	-0.2	0.2
Latency to leave start box in cocaine runway	1.8	2.0	2.9	-1.7	1.7	1.1	-1.1
Latency to leave start box in cocaine runway, F	2.9	3.3	4.0	-2.0	2.0	1.6	-1.6
Latency to leave start box in cocaine runway, M	0.3	0.3	0.6	0.0	0.0	-0.8	0.8
Std. dev. time between licks in bursts	0.2	0.3	0.3	-0.5	0.5	0.5	-0.5
Total sessions with >9 infusions	0.2	0.2	0.3	0.2	-0.2	-0.6	0.6
Short access day 1 total inactive lever presses	1.3	1.7	2.1	1.1	-1.1	-1.5	1.5
Short access day 10 total inactive lever presses	0.1	0.3	0.5	-0.7	0.7	0.3	-0.3
Short access day 1 total infusions	0.4	0.6	1.0	0.4	-0.4	-1.0	1.0
Short access day 10 total infusions	0.3	0.4	0.5	0.5	-0.5	-0.7	0.7
Short access total infusions	0.2	0.2	0.4	0.1	-0.1	-0.6	0.6
Short access day 1 locomotion	1.1	1.4	1.7	1.0	-1.0	-1.3	1.3
Short access day 10 total locomotion	1.3	2.4	3.2	1.8	-1.8	-1.3	1.3
Short access total locomotion	0.3	0.4	0.5	0.5	-0.5	-0.7	0.7
One hour access (0.3 mA shock)	0.2	0.3	0.4	-0.4	0.4	0.6	-0.6
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.4	0.2	-0.2
One hour access (shock baseline)	0.1	0.1	0.3	-0.5	0.5	-0.0	0.0
Social response proportion	0.1	0.2	0.3	-0.2	0.1	0.6	-0.6
Social responses	0.1	0.1	0.2	-0.0	-0.0	0.4	-0.4
Social time	0.7	0.9	1.6	-0.5	0.5	1.3	-1.3
Soleus weight	0.2	0.6	1.0	0.4	-0.5	1.0	-1.0
Bone: stiffness	0.0	0.1	0.1	-0.2	0.1	0.3	-0.3
Tibialis anterior weight	1.7	5.9	6.3	-2.4	2.3	2.5	-2.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.1	-0.1	0.4	-0.4
Time to tail flick, test, before self-admin	1.2	1.3	1.8	-0.9	0.9	1.4	-1.4
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	-0.4	0.1	-0.1
Delta time to tail flick, test, before/after SA	2.5	2.5	2.9	1.5	-1.5	-1.7	1.7
Tibia length	2.3	6.3	8.4	-2.1	2.0	2.9	-2.9
Ambulatory time before self-admin	0.2	0.3	0.6	-0.7	0.8	-0.2	0.2
Ambulatory time after self-admin	2.5	2.9	3.7	-1.9	1.9	1.5	-1.5
Bone: tissue strength	0.9	0.9	1.3	-0.8	0.8	1.1	-1.1
Total heroin consumption	0.9	1.0	1.5	0.7	-0.8	-1.2	1.2
Bone: trabecular number	4.2	6.9	8.6	2.9	-2.9	-2.3	2.3
Bone: trabecular spacing	2.9	3.9	4.7	-1.8	1.7	2.2	-2.2
Bone: trabecular thickness	0.1	0.1	0.1	0.2	-0.2	-0.3	0.3
Bone: trabecular tissue density	0.4	0.6	1.1	0.5	-0.4	-1.0	1.0
Water consumed over 24 hours	0.2	0.3	0.5	-0.4	0.3	0.7	-0.7
Number of responses in last shaping day	0.3	0.3	0.6	0.3	-0.2	-0.8	0.8