Hub : Genes

Neurod2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative TSS	NM_019326.2	0.08	0.07	8.3e-05	0	0.02	0	0	7.6e-02	5.0e-03	1.5e-01	1.2e-01
2	PL	alternative TSS	XM_039086671.1	0.09	0.07	8.8e-05	0	0.02	0	0	7.7e-02	5.0e-03	1.1e-01	9.6e-02
3	PL	isoform ratio	NM_019326.2	0.34	0.15	9.7e-03	0	0.01	0	0	9.1e-02	2.0e-02	1.5e-01	1.8e-01
4	PL	isoform ratio	XM_039086671.1	0.34	0.15	7.8e-03	0.01	0.01	0	0	7.3e-02	1.5e-02	1.0e-01	9.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.3	4.1	-2.0	2.0	-0.8	0.7
Area under the delay curve	0.3	0.3	0.6	-0.8	0.8	-0.1	0.0
BMI with tail	2.6	8.4	9.1	3.0	-3.0	2.8	-2.8
BMI without tail	0.1	0.2	0.4	0.4	-0.4	-0.6	0.5
Body weight	6.0	25.0	32.8	5.7	-5.7	4.4	-4.0
Weight adjusted by age	0.3	0.4	0.4	0.6	-0.6	0.6	-0.6
Bone surface	0.2	0.3	0.5	0.2	-0.2	0.7	-0.7
Bone volume	0.2	0.4	0.8	-0.1	0.1	0.8	-0.9
Breakpoint value in progressive ratio session	0.5	0.5	0.9	0.9	-0.9	-0.3	0.4
Number of licking bursts	0.2	0.3	0.4	-0.5	0.4	0.5	-0.7
Context. condit. distance diff. score	0.2	0.2	0.3	0.6	-0.5	-0.2	0.4
Locomotion velocity, session 1	0.6	0.6	1.0	1.0	-1.0	0.5	-0.5
Locomotion distance, session 1	4.1	5.3	6.5	2.5	-2.6	2.1	-2.0
Locomotion velocity, session 2	0.2	0.2	0.4	0.6	-0.6	-0.2	0.3
Locomotion distance, session 2	1.1	1.5	1.8	1.3	-1.3	1.2	-1.2
Locomotion velocity, session 3	0.3	0.3	0.7	0.1	-0.1	-0.8	0.8
Locomotion distance, session 3	0.2	0.2	0.4	0.7	-0.7	-0.1	0.1
Stereotopy head waving bouts, day 3	2.7	3.2	5.0	-2.2	2.2	-1.2	1.1
Stereotopy head waving duration, day 3	0.2	0.2	0.5	-0.7	0.7	0.2	-0.2
Locomotion velocity, session 7	1.5	1.7	1.8	1.3	-1.3	1.3	-1.3
Locomotion distance, session 7	0.6	0.7	1.1	0.6	-0.6	1.0	-1.0
Stereotopy head waving bouts, day 7	0.5	0.5	1.0	-1.0	1.0	-0.4	0.3
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.6	0.6	-0.4	0.4
Locomotion velocity, session 8	5.2	6.2	9.4	3.1	-3.0	1.9	-1.6
Locomotion distance, session 8	1.3	1.9	2.7	1.6	-1.6	1.0	-1.0
Degree of sensitization distance	0.9	0.9	1.4	0.8	-0.7	1.2	-1.1
Degree of sensitization stereotypy	0.7	0.7	1.5	-1.2	1.2	-0.2	0.1
Conditioned locomotion	0.3	0.3	0.4	-0.5	0.5	-0.6	0.6
Cocaine response after cond. corrected	1.4	1.6	2.3	-1.1	1.1	1.3	-1.5
Cocaine response after cond. not corrected	2.0	2.3	3.0	-1.4	1.3	1.5	-1.7
Cocaine response before conditioning	0.3	0.4	0.8	-0.9	0.9	-0.1	0.1
Saline control response	0.7	0.9	2.0	-0.0	-0.0	1.3	-1.4
Bone: connectivity density	2.3	3.5	5.5	-2.3	2.3	-1.4	1.2
Bone: cortical apparent density	6.0	7.9	10.8	-3.3	3.3	-2.3	2.2
Bone: cortical area	0.1	0.2	0.2	-0.5	0.5	-0.3	0.2
Bone: cortical porosity	0.5	0.5	1.0	-0.5	0.4	0.9	-1.0
Bone: cortical porosity	0.7	0.7	1.5	-0.4	0.4	1.1	-1.2
Bone: cortical thickness	1.8	2.9	3.5	-1.9	1.9	-1.6	1.5
Bone: cortical thickness	5.2	6.0	7.9	-2.8	2.8	-2.1	2.0
Bone: cortical tissue density	5.9	7.8	10.8	-3.3	3.3	-2.3	2.1
Condit. Reinf. active minus inactive responses	1.4	1.6	2.0	-1.1	1.1	-1.4	1.4
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.7	-1.3	1.4	-1.9	1.9
Condit. Reinf. active responses	1.2	1.5	1.5	-1.2	1.2	-1.2	1.2
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.6	0.6	0.3	-0.4
Incentive salience index mean	1.8	2.2	2.5	-1.6	1.6	-1.4	1.3
Condit. Reinf. lever presses	0.6	0.8	1.4	-1.2	1.2	-0.5	0.4
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	-0.8	0.8	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	0.5	-0.4	0.3
Condit. Reinf. active responses	0.5	0.7	1.2	-1.1	1.0	-0.5	0.4
Condit. Reinf. inactive responses	0.8	1.0	2.0	-1.4	1.4	-0.1	-0.0
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4
Condit. Reinf. lever reinforcers received	0.7	0.9	1.3	-1.1	1.1	-0.8	0.7
Conditioned reinforcement - actives	0.6	0.6	1.0	-1.0	1.0	0.4	-0.4
Conditioned reinforcement - inactives	1.8	2.0	2.2	-1.4	1.4	-1.5	1.5
Conditioned locomotion	0.5	0.6	1.0	-1.0	1.0	-0.5	0.4
Patch foraging indifference point 0 sec	1.9	3.0	3.6	-1.9	1.9	-1.6	1.5
Patch foraging indifference point AUC	0.2	0.3	0.6	0.1	-0.1	0.7	-0.7
Delay disc. indifference point, 0s delay	1.4	1.5	1.8	-1.2	1.2	-1.3	1.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.3	-1.1	1.1	-0.9	0.9
Delay disc. indifference point, 2s delay	1.0	1.1	1.5	-1.2	1.2	0.8	-1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.3	0.4	-0.4
Delay disc. indifference point, 4s delay	0.8	0.9	1.3	-0.8	0.8	-1.1	0.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.6	0.6	0.2	-0.3
Indifference point function ln k	0.6	0.8	1.5	-0.3	0.3	-1.2	1.2
Indifference point function log k	0.6	0.8	1.5	-0.3	0.3	-1.2	1.2
Patch foraging total patch changes 0 sec	1.5	2.4	2.6	-1.6	1.6	-1.5	1.5
Patch foraging total patch changes 12 sec	2.6	3.3	6.5	-2.5	2.5	-0.5	0.4
Patch foraging total patch changes 18 sec	0.4	0.6	1.0	-1.0	1.0	-0.4	0.3
Patch foraging total patch changes 24 sec	2.0	2.4	3.3	-1.8	1.8	-1.3	1.1
Patch foraging total patch changes 6 sec	1.6	2.3	3.3	-1.8	1.8	-1.2	1.1
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.3	0.3	-0.6	0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.0	-0.0	-0.2	0.2
Patch foraging water rate 12 sec	0.4	0.6	1.1	0.4	-0.4	-1.0	1.1
Patch foraging water rate 18 sec	0.2	0.3	0.4	-0.6	0.6	-0.5	0.4
Patch foraging water rate 24 sec	0.3	0.4	0.5	-0.6	0.6	-0.7	0.7
Patch foraging water rate 6 sec	0.6	0.9	1.4	-1.2	1.2	-0.7	0.6
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	3.0	-0.5	0.5	-1.7	1.7
Distance traveled before self-admin	0.3	0.4	0.4	0.6	-0.7	-0.6	0.5
Distance traveled after self-admin	2.4	2.7	2.9	1.6	-1.6	1.7	-1.5
Extensor digitorum longus weight	5.1	20.1	34.6	5.9	-5.8	2.7	-2.3
Bone: elastic displacement	0.1	0.1	0.3	-0.1	0.1	-0.5	0.5
Bone: elastic work	0.0	0.1	0.1	0.0	-0.1	0.3	-0.3
Bone: endosteal estimation	3.1	6.7	7.4	2.7	-2.7	2.5	-2.4
Bone: endosteal perimeter	1.6	3.4	4.7	2.2	-2.2	1.5	-1.4
Epididymis fat weight	0.9	2.1	3.3	1.1	-1.1	1.8	-1.7
Delta time in closed arm before/after self-admin	2.3	2.2	4.2	2.1	-2.1	0.4	-0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.2	0.2	0.0	-0.0
Diff in mean of infusions in LGA sessions	0.4	0.5	0.6	0.7	-0.7	0.8	-0.6
Delay discount exponential model param	0.1	0.1	0.3	0.5	-0.5	-0.0	0.1
Extinction: sum of active levers before priming	1.5	1.5	1.6	1.2	-1.3	1.2	-1.2
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.2
Bone: final force	0.8	1.3	2.0	-0.9	0.8	1.3	-1.4
Bone: final moment	0.8	1.3	2.3	-0.7	0.7	1.4	-1.5
Food consumed during 24 hour testing period	0.9	1.0	1.3	1.1	-1.1	0.9	-0.9
Glucose	0.3	0.4	0.6	-0.6	0.5	0.6	-0.8
Heart weight	2.4	3.4	5.8	2.4	-2.4	1.0	-0.9
Delay discount hyperbolic model param	0.2	0.2	0.4	0.7	-0.6	0.0	0.1
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.4	0.4	-0.1	0.2
Intermittent access intake escalation	0.2	0.2	0.3	-0.3	0.3	-0.5	0.6
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	-0.3	-0.5	0.4
Intermitt. access day 1 inactive lever presses	0.4	0.5	0.9	-0.9	0.9	-0.1	0.2
Intermitt. access day 15 inactive lever presses	7.9	8.6	13.8	-2.2	2.2	-3.7	3.4
Intermitt. access escalation Index	1.3	1.2	1.5	1.0	-1.0	1.2	-1.1
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3
Intermittent access day 15 total infusions	0.2	0.2	0.3	-0.5	0.5	-0.3	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	-0.6	0.6	0.1	0.0
Intermittent access total infusions	0.1	0.1	0.2	-0.1	0.1	0.4	-0.3
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.6	0.6	-0.4	0.4
Intermittent access day 15 total locomotion	0.6	0.6	1.0	-0.7	0.7	-1.0	0.8
Intermittent access total locomotion	1.1	1.3	1.8	-1.0	1.0	-1.3	1.2
Intermittent access standard deviation	1.5	1.6	2.4	-0.9	0.9	-1.5	1.6
Left kidney weight	0.8	2.3	4.4	2.1	-2.0	-0.4	0.6
Right kidney weight	0.2	0.7	1.1	1.0	-1.1	0.6	-0.5
Cocaine induced anxiety	2.9	3.3	3.8	1.9	-1.9	1.7	-1.7
Post-drug Anxiety	0.4	0.4	0.7	0.4	-0.4	0.8	-0.8
Baseline Anxiety	3.1	3.3	3.9	-1.9	2.0	-1.7	1.6
Tail length	0.5	1.6	1.8	1.2	-1.2	-1.3	1.4
Length with tail	2.4	8.7	16.0	4.0	-4.0	1.4	-1.1
Length without tail	5.1	11.2	13.4	3.6	-3.7	3.2	-2.9
Times rat made contact with spout	0.5	0.6	1.1	-1.1	1.0	-0.4	0.2
Lifetime Intake	0.0	0.1	0.1	-0.1	0.1	0.4	-0.2
Liver weight, left	0.1	0.2	0.3	0.2	-0.2	-0.5	0.5
Liver weight, right	0.2	0.3	0.4	-0.4	0.4	-0.6	0.6
Locomotor activity	0.2	0.3	0.5	-0.7	0.6	0.4	-0.5
Locomotor testing distance	1.4	2.3	4.1	-2.0	2.0	-0.8	0.6
Locomotor testing rearing	6.7	10.4	11.6	-3.4	3.4	-3.2	2.9
Locomotion in novel chamber	10.2	12.5	19.9	-2.8	2.8	-4.5	3.8
Locomotion in novel chamber post-restriction	0.5	0.7	1.1	-0.6	0.5	0.9	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.5	-0.5	-0.0	-0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	-0.1	0.1	0.8	-0.7
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.1	-1.0	1.0	-0.3	0.3
Bouts of movement, locomotor time 1	1.0	1.1	1.6	0.9	-0.9	1.3	-1.1
Total resting periods, locomotor time 1	2.2	2.4	3.7	1.2	-1.2	1.9	-1.8
Rest time, locomotor task time 1	0.4	0.4	0.9	0.1	-0.1	1.0	-0.9
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	-0.2	0.1
Time >=10cm from walls, locomotor time 2	1.9	2.0	2.2	-1.4	1.5	-1.5	1.3
Bouts of movement, locomotor time 2	1.5	1.6	2.9	-0.6	0.6	-1.7	1.7
Total resting periods, locomotor time 2	1.6	1.7	3.2	-0.4	0.4	-1.8	1.8
Rest time, locomotor task time 2	0.6	0.7	1.4	1.2	-1.2	-0.2	0.2
Distance moved, locomotor task time 2	0.3	0.3	0.7	0.1	-0.1	0.8	-0.8
Vertical activity count, locomotor time 2	0.2	0.3	0.4	0.4	-0.4	0.6	-0.6
Light reinforcement 1	1.5	2.6	4.1	-2.0	2.0	-1.2	1.0
Light reinforcement 2	0.4	0.6	0.8	-0.6	0.6	0.8	-0.9
Bone: marrow area	2.8	6.2	7.0	2.6	-2.6	2.4	-2.3
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1
Bone: maximum force	0.7	1.2	2.4	0.2	-0.2	1.5	-1.5
Bone: maximum moment	0.7	1.2	2.4	0.3	-0.3	1.5	-1.6
Mean time between licks in bursts	1.2	1.7	2.3	1.5	-1.5	1.0	-1.0
Mean num. licks in bursts	0.2	0.3	0.5	-0.3	0.3	-0.7	0.7
Cd content in liver	0.1	0.1	0.1	-0.2	0.2	0.4	-0.4
Co content in liver	0.4	0.4	0.9	0.9	-0.9	0.1	0.1
Cu content in liver	0.2	0.2	0.3	0.5	-0.5	-0.4	0.5
Fe content in liver	1.2	1.4	2.1	1.4	-1.5	0.8	-0.8
K content in liver	0.7	0.7	0.8	-0.9	0.9	-0.8	0.7
Mg content in liver	2.7	2.8	4.0	-1.2	1.3	-2.0	2.0
Mn content in liver	2.3	2.6	3.1	-1.4	1.4	-1.8	1.8
Na content in liver	0.5	0.6	1.2	-0.2	0.2	1.0	-1.1
Rb content in liver	1.2	1.4	1.8	-1.3	1.3	-1.1	1.0
Se content in liver	3.7	4.5	5.4	-2.3	2.3	-1.9	1.9
Sr content in liver	0.6	0.5	1.2	-0.0	0.1	-1.0	1.1
Zn content in liver	2.0	2.2	2.6	-1.6	1.6	-1.4	1.3
Bone: minimum diameter	0.8	1.5	1.6	1.2	-1.2	1.3	-1.2
Time in familiar zone, hab. session 1	0.6	0.6	1.4	-0.2	0.1	1.0	-1.2
Time in novel zone, hab. session 1	2.1	2.0	2.5	-1.2	1.3	-1.5	1.6
Total zone transitions, hab. session 1	1.1	1.6	2.8	1.7	-1.7	0.7	-0.5
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.8	-0.8	0.2	-0.1
Time in familiar zone, hab. session 2	0.1	0.2	0.2	-0.4	0.4	0.3	-0.4
Time in novel zone, hab. session 2	0.8	0.8	1.3	-0.5	0.6	-1.1	1.1
Total zone transitions, hab. session 2	1.0	1.2	1.3	1.1	-1.2	1.1	-1.1
Total locomotion distance, hab. session 2	0.6	0.7	1.0	0.7	-0.7	1.0	-1.0
Locomotion velocity, hab. session 2	0.8	1.1	1.2	1.0	-1.0	1.1	-1.1
Novel to familiar place preference ratio	0.6	0.6	0.7	0.9	-0.8	-0.6	0.8
Novelty place preference	0.6	0.6	1.1	0.6	-0.5	-0.9	1.0
Time in novel zone, NPP test	0.6	0.6	1.3	0.1	-0.0	-1.0	1.1
Total zone transitions, NPP test	1.6	2.2	3.2	1.1	-1.1	1.8	-1.8
Total locomotion distance, NPP test	0.6	0.8	1.6	0.3	-0.3	1.2	-1.2
Locomotion velocity, NPP test	0.9	1.3	1.8	0.9	-0.9	1.3	-1.3
Intraocular pressure	1.2	1.7	2.6	1.6	-1.6	1.0	-0.9
Delta distance traveled before/after self-admin	1.2	1.3	1.6	1.1	-1.1	1.3	-1.1
Delta ambulatory time before/after self-admin	2.5	2.7	5.4	0.8	-0.8	2.3	-2.1
Parametrial fat weight	0.2	0.4	0.9	-0.9	0.9	0.1	-0.1
Pavlov. Cond. lever latency	1.1	1.3	2.8	1.7	-1.6	0.1	0.1
Pavlov. Cond. magazine entry latency	5.9	7.6	13.3	-3.7	3.6	-1.6	1.3
Pavlov. Cond. change in total contacts	8.5	9.1	11.6	-3.4	3.4	-2.7	2.5
Pavlov. Cond. index score	4.2	5.3	10.1	-3.2	3.1	-1.0	0.7
Pavlov. Cond. latency score	3.0	3.9	7.6	-2.7	2.7	-0.7	0.4
Pavlov. Cond. lever contacts	0.9	1.0	2.2	-1.5	1.4	-0.1	-0.2
Pavlov. Cond. magazine entry number	7.9	9.9	17.0	4.1	-4.1	1.9	-1.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.4	1.2	-1.1	-0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.4	11.7	-3.4	3.4	-1.3	1.0
Pavlov. Cond. response bias	6.0	7.2	12.3	-3.5	3.5	-1.7	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	-0.5	0.3	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	0.3	-0.4	0.4	-0.5
Pavlov. Cond. change in total contacts	0.6	0.8	0.9	-0.9	0.9	-0.9	0.8
Pavlov. Cond. index score	0.0	0.1	0.1	-0.3	0.3	0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	0.1	0.2	-0.3
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.8	0.8	0.0	-0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.0	1.0	-0.9	-0.6	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2
Pavlov. Cond. response bias	0.3	0.5	1.0	-1.0	0.9	-0.3	0.1
Time in closed arm before self-admin	0.9	1.0	2.0	-1.4	1.4	0.0	0.1
Time in closed arm after self-admin	0.4	0.4	0.8	0.4	-0.4	-0.8	0.9
Time in open arm before self-admin	1.7	1.8	3.6	1.9	-1.9	-0.3	0.3
Time in open arm after self-admin	0.4	0.4	0.8	0.9	-0.9	-0.1	0.1
Bone: periosteal estimation	0.6	1.2	1.6	0.9	-1.0	1.2	-1.3
Bone: periosteal perimeter	1.1	1.9	2.0	1.4	-1.4	1.4	-1.4
Bone: post-yield work	1.3	1.7	1.9	1.4	-1.4	1.3	-1.2
Progressive ratio test 1 active lever presses	0.7	0.7	1.3	-1.1	1.1	0.2	-0.2
Progressive ratio test 1 breakpoint	0.8	0.9	1.1	-1.0	1.0	0.8	-0.8
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.5	-1.2	1.2	-0.9	0.9
Progressive ratio test 2 active lever presses	1.3	1.4	1.6	-1.3	1.3	-1.2	1.1
Progressive ratio test 2 breakpoint	0.8	0.9	1.3	-1.2	1.2	-0.7	0.7
Progressive ratio test 2 inactive lever presses	1.8	2.1	4.3	-0.5	0.5	-2.1	1.9
Incentive Sensitization - Responses	1.8	1.8	2.4	-1.2	1.2	-1.6	1.4
Incentive Sensitization - Breakpoint	2.0	2.0	2.9	-1.2	1.2	-1.7	1.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.5	0.5	0.1	-0.1
Progressive ratio	0.0	0.0	0.1	0.0	-0.0	0.1	-0.2
Food seeking constrained by brief footshock	1.2	1.5	3.0	-0.4	0.3	1.7	-1.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2
Retroperitoneal fat weight	0.4	1.4	2.3	0.7	-0.7	1.5	-1.4
Reaction time number correct	0.7	1.0	1.8	1.3	-1.3	0.5	-0.6
Reaction time mean minus median	0.0	0.1	0.1	0.3	-0.3	0.1	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.4	0.4	-0.3	0.2
Reaction time num false alarms	0.2	0.3	0.5	-0.7	0.6	0.3	-0.5
Reaction time num false alarms AUC	0.3	0.4	0.6	-0.5	0.5	0.6	-0.7
Reaction time trials correct on left	0.7	1.0	1.8	1.3	-1.3	0.5	-0.6
Reaction time trials on left	0.7	1.0	1.7	1.3	-1.3	0.6	-0.6
Reaction time mean	1.3	1.9	3.4	-0.6	0.6	-1.8	1.8
Reaction time mean AUC	1.3	1.8	3.3	-0.5	0.6	-1.8	1.8
Median of all reaction times	2.6	3.6	5.8	-1.2	1.2	-2.4	2.4
Reaction time omissions	0.4	0.5	1.1	-1.0	1.0	0.1	-0.1
Reaction time false alarm rate	0.5	0.7	1.2	-1.1	1.1	0.3	-0.4
Reaction time premature initiation rate	0.4	0.6	1.1	-0.5	0.5	1.0	-0.9
Reaction time premature initiations	0.6	0.9	1.7	0.5	-0.5	1.3	-1.2
Std. dev. reaction times	0.0	0.1	0.1	-0.1	0.2	-0.3	0.3
Reaction time trials completed	0.7	1.0	1.7	1.3	-1.3	0.6	-0.6
Reaction time trials AUC	0.5	0.7	1.3	1.1	-1.2	0.3	-0.4
Run reversals in cocaine runway, females	1.1	1.1	2.0	1.4	-1.4	-0.4	0.6
Run reversals in cocaine runway, males	2.7	2.6	5.5	-0.7	0.7	-2.3	2.0
Latency to leave start box in cocaine runway	1.4	1.5	2.9	1.7	-1.7	0.2	-0.2
Latency to leave start box in cocaine runway, F	1.6	1.8	3.0	1.7	-1.7	0.8	-0.7
Latency to leave start box in cocaine runway, M	2.4	2.3	4.8	-0.1	0.1	-2.2	2.1
Std. dev. time between licks in bursts	0.1	0.2	0.3	0.5	-0.5	0.3	-0.3
Total sessions with >9 infusions	0.5	0.5	1.1	-1.0	1.0	-0.0	0.1
Short access day 1 total inactive lever presses	1.2	1.4	1.8	-1.4	1.3	-1.0	0.9
Short access day 10 total inactive lever presses	0.3	0.4	0.5	0.7	-0.7	0.6	-0.4
Short access day 1 total infusions	0.3	0.3	0.4	-0.6	0.6	-0.4	0.5
Short access day 10 total infusions	0.1	0.1	0.2	-0.4	0.4	0.0	-0.0
Short access total infusions	0.1	0.1	0.2	-0.2	0.2	0.4	-0.3
Short access day 1 locomotion	2.4	2.6	3.7	-1.9	1.9	-1.3	1.2
Short access day 10 total locomotion	1.3	1.4	2.0	-1.4	1.4	-1.0	0.8
Short access total locomotion	0.3	0.3	0.6	-0.7	0.8	0.0	0.1
One hour access (0.3 mA shock)	0.3	0.3	0.8	-0.1	0.1	0.9	-0.7
Compulsive drug intake	0.8	0.8	1.9	0.1	-0.0	1.4	-1.1
One hour access (shock baseline)	0.1	0.1	0.2	-0.3	0.2	-0.5	0.4
Social response proportion	0.2	0.2	0.5	0.2	-0.2	0.7	-0.7
Social responses	0.4	0.5	1.0	-0.0	-0.0	0.9	-1.0
Social time	1.0	1.3	2.3	0.6	-0.6	1.4	-1.5
Soleus weight	0.4	1.3	2.8	-0.4	0.3	1.4	-1.7
Bone: stiffness	0.4	0.7	1.4	0.0	-0.1	1.2	-1.2
Tibialis anterior weight	1.0	3.3	5.5	2.3	-2.4	1.1	-1.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	-0.2	0.1	0.8	-0.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.1
Time to tail flick, test, before self-admin	2.1	2.1	3.1	1.2	-1.2	1.8	-1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.1	0.0	0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.3	0.2	0.7	-0.8
Delta time to tail flick, test, before/after SA	3.0	2.7	3.8	-1.5	1.5	-2.0	1.6
Tibia length	2.4	6.8	8.5	2.2	-2.3	2.9	-2.9
Ambulatory time before self-admin	0.7	0.7	1.1	0.7	-0.7	-1.1	1.0
Ambulatory time after self-admin	4.3	4.8	5.4	2.1	-2.2	2.3	-2.1
Bone: tissue strength	0.7	0.7	0.8	0.7	-0.7	0.9	-0.9
Total heroin consumption	0.4	0.5	0.8	-0.6	0.5	-0.9	0.7
Bone: trabecular number	2.7	4.2	7.9	-2.8	2.8	-0.9	0.7
Bone: trabecular spacing	2.7	3.5	4.4	1.6	-1.7	2.1	-2.1
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4
Bone: trabecular tissue density	1.2	1.7	3.1	-0.6	0.7	-1.7	1.8
Water consumed over 24 hours	0.2	0.2	0.4	0.2	-0.2	0.6	-0.6
Number of responses in last shaping day	1.0	1.1	2.0	-0.4	0.4	-1.4	1.4