Hub : Genes

Nek8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Nek8 0.13 0.1 1.1e-13 0.1 0.13 0.12 0.12 3.0e-11 4.0e-14 1.7e-12 1.7e-13
2 BLA gene expression Nek8 0.08 0.07 4.4e-04 0.03 0.04 0.04 0.04 9.0e-03 2.9e-03 3.3e-03 3.9e-03
3 IC gene expression Nek8 0.12 0.1 2.6e-04 0.05 0.07 0.04 0.06 3.2e-03 7.1e-04 6.3e-03 1.2e-03
4 RMTg alternative polyA NM_001105804.2 0.1 0.09 6.4e-03 0.09 0.1 0.09 0.08 2.1e-03 1.6e-03 1.8e-03 3.2e-03
5 NAcc gene expression Nek8 0.1 0.07 0.0e+00 0.11 0.12 0.11 0.12 9.6e-17 1.2e-17 3.1e-16 1.7e-17
6 IL gene expression Nek8 0.22 0.18 1.6e-04 0.11 0.16 0.1 0.17 1.3e-03 1.0e-04 1.8e-03 6.2e-05
7 Brain gene expression Nek8 0.1 0.07 5.9e-10 0.11 0.1 0.11 0.1 2.3e-10 5.2e-10 4.8e-10 9.9e-10
8 pVTA gene expression Nek8 0.16 0.12 7.1e-12 0.12 0.14 0.14 0.13 1.6e-09 3.8e-11 3.4e-11 7.4e-11
9 LHb gene expression Nek8 0.23 0.19 1.5e-04 0.1 0.15 0.17 0.14 2.5e-03 2.3e-04 6.3e-05 2.9e-04
10 Adipose gene expression Nek8 0.02 0.02 6.8e-03 0.01 0 0 0 3.3e-02 1.2e-01 1.0e-01 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.33.94.11.92.02.0-2.02.02.02.02.02.02.0
Area under the delay curve2.32.73.2-1.3-1.5-1.61.6-1.6-1.7-1.6-1.7-1.7-1.8
BMI with tail1.75.96.52.52.52.4-2.52.52.32.42.42.42.3
BMI without tail2.26.67.12.52.62.6-2.62.62.52.62.62.72.3
Body weight2.511.012.43.53.53.4-3.43.43.33.23.33.32.8
Weight adjusted by age0.10.20.50.30.40.4-0.40.40.50.20.50.50.7
Bone surface1.73.03.41.71.71.7-1.71.71.71.81.81.81.7
Bone volume1.42.62.71.61.61.6-1.61.61.61.61.61.61.6
Breakpoint value in progressive ratio session0.70.81.10.70.80.9-0.90.91.00.70.91.00.9
Number of licking bursts0.20.40.4-0.7-0.6-0.60.6-0.6-0.5-0.5-0.6-0.6-0.6
Context. condit. distance diff. score0.60.70.80.90.80.8-0.80.80.80.80.80.80.9
Locomotion velocity, session 12.12.32.51.61.61.5-1.51.51.51.41.51.51.4
Locomotion distance, session 10.20.30.40.60.60.5-0.50.50.50.30.50.60.2
Locomotion velocity, session 20.00.00.10.20.20.2-0.20.20.20.10.20.30.2
Locomotion distance, session 21.21.61.71.31.31.3-1.31.31.31.31.31.31.3
Locomotion velocity, session 33.13.64.1-2.0-2.0-1.91.9-1.9-1.9-1.7-1.9-1.9-1.7
Locomotion distance, session 30.50.50.6-0.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.7-0.8
Stereotopy head waving bouts, day 30.00.00.10.00.10.1-0.10.10.20.30.20.20.3
Stereotopy head waving duration, day 30.30.40.7-0.9-0.7-0.60.6-0.6-0.5-0.3-0.5-0.5-0.4
Locomotion velocity, session 70.40.40.60.50.60.6-0.60.60.70.80.70.70.7
Locomotion distance, session 70.50.70.70.70.80.8-0.80.80.80.80.80.90.7
Stereotopy head waving bouts, day 70.60.60.90.70.80.8-0.80.80.80.90.80.81.0
Stereotopy head waving duration, day 70.30.40.50.50.50.6-0.60.60.60.70.60.60.7
Locomotion velocity, session 80.00.00.00.20.20.1-0.10.10.10.20.10.10.0
Locomotion distance, session 80.81.21.21.11.11.1-1.11.11.11.01.11.11.1
Degree of sensitization distance3.43.53.61.81.91.9-1.91.91.91.91.91.91.8
Degree of sensitization stereotypy0.60.70.90.80.80.8-0.80.80.80.80.80.81.0
Conditioned locomotion1.41.62.1-1.5-1.4-1.31.3-1.3-1.2-1.1-1.3-1.2-1.1
Cocaine response after cond. corrected1.61.92.21.41.41.4-1.41.41.41.41.31.31.5
Cocaine response after cond. not corrected2.22.62.91.61.61.6-1.61.61.61.71.51.51.7
Cocaine response before conditioning0.20.30.30.50.50.5-0.50.50.50.60.50.50.4
Saline control response0.00.00.1-0.1-0.0-0.00.0-0.0-0.10.20.1-0.00.2
Bone: connectivity density4.16.47.12.42.52.5-2.52.52.52.62.62.52.7
Bone: cortical apparent density0.40.50.7-0.8-0.8-0.70.7-0.7-0.7-0.6-0.7-0.7-0.7
Bone: cortical area1.62.43.1-1.5-1.5-1.51.5-1.5-1.5-1.6-1.6-1.5-1.8
Bone: cortical porosity0.30.30.50.50.60.6-0.60.60.50.70.60.60.6
Bone: cortical porosity0.10.10.20.30.40.4-0.40.40.30.50.40.40.4
Bone: cortical thickness2.84.65.0-2.2-2.2-2.12.1-2.1-2.0-2.2-2.2-2.1-2.2
Bone: cortical thickness0.00.00.0-0.2-0.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.1
Bone: cortical tissue density0.20.30.4-0.6-0.6-0.50.5-0.5-0.5-0.4-0.5-0.5-0.5
Condit. Reinf. active minus inactive responses0.60.70.9-0.9-0.9-0.90.9-0.9-0.8-0.8-0.8-0.8-0.8
Condit. Reinf. active-inactive response ratio0.20.20.2-0.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4
Condit. Reinf. active responses0.00.00.0-0.2-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1-0.0
Condit. Reinf. inactive responses0.30.40.50.60.60.6-0.60.60.60.60.60.60.7
Incentive salience index mean0.20.30.4-0.6-0.6-0.60.6-0.6-0.6-0.5-0.6-0.6-0.4
Condit. Reinf. lever presses0.10.10.20.30.30.3-0.30.30.30.40.30.30.5
Condit. Reinf. active minus inactive responses0.20.30.6-0.8-0.7-0.50.6-0.6-0.5-0.4-0.5-0.4-0.4
Condit. Reinf. active-inactive response ratio0.50.60.8-0.9-0.8-0.80.8-0.8-0.8-0.6-0.7-0.7-0.6
Condit. Reinf. active responses0.10.20.4-0.6-0.5-0.40.4-0.4-0.3-0.3-0.3-0.3-0.3
Condit. Reinf. inactive responses0.00.10.10.10.20.2-0.20.20.40.20.20.30.2
Condit. Reinf. lever presses2.43.33.7-1.9-1.9-1.81.9-1.8-1.9-1.8-1.8-1.8-1.7
Condit. Reinf. lever reinforcers received0.30.50.8-0.9-0.8-0.70.7-0.7-0.6-0.6-0.6-0.6-0.6
Conditioned reinforcement - actives0.20.40.60.60.60.6-0.60.60.50.70.60.50.8
Conditioned reinforcement - inactives0.10.10.20.50.40.3-0.30.30.30.10.20.30.1
Conditioned locomotion0.20.30.70.70.60.5-0.50.50.30.60.40.30.8
Patch foraging indifference point 0 sec0.40.71.1-0.9-0.8-0.80.8-0.8-0.7-1.1-0.8-0.6-0.8
Patch foraging indifference point AUC2.02.83.3-1.8-1.8-1.81.8-1.8-1.8-1.3-1.7-1.8-1.3
Delay disc. indifference point, 0s delay1.01.11.8-0.8-0.9-1.01.0-1.0-1.1-1.0-1.1-1.1-1.4
Delay disc. indifference point, 16s delay1.82.02.8-1.0-1.2-1.41.4-1.4-1.5-1.6-1.5-1.5-1.7
Delay disc. indifference point, 2s delay2.73.03.3-1.6-1.7-1.81.8-1.8-1.7-1.6-1.7-1.7-1.8
Delay disc. indifference point, 24s delay0.70.71.20.90.80.8-0.80.80.81.10.80.80.9
Delay disc. indifference point, 4s delay0.30.30.6-0.3-0.5-0.50.5-0.5-0.6-0.6-0.6-0.6-0.8
Delay disc. indifference point, 8s delay1.11.31.8-0.9-1.1-1.21.2-1.2-1.3-1.0-1.2-1.4-0.9
Indifference point function ln k0.50.81.10.91.01.0-1.01.01.00.41.01.10.5
Indifference point function log k0.50.81.10.91.01.0-1.01.01.00.41.01.10.5
Patch foraging total patch changes 0 sec0.30.50.9-0.8-0.7-0.70.7-0.7-0.6-0.9-0.7-0.5-0.7
Patch foraging total patch changes 12 sec0.20.30.4-0.5-0.5-0.50.5-0.5-0.5-0.6-0.5-0.5-0.5
Patch foraging total patch changes 18 sec1.52.32.6-1.6-1.6-1.51.5-1.5-1.4-1.6-1.5-1.4-1.5
Patch foraging total patch changes 24 sec1.72.93.5-1.9-1.8-1.71.7-1.7-1.7-1.6-1.7-1.6-1.4
Patch foraging total patch changes 6 sec3.35.15.3-2.3-2.3-2.32.3-2.3-2.3-2.1-2.3-2.3-2.1
Patch foraging time to switch 0 sec1.22.42.71.61.61.5-1.51.51.51.61.51.41.5
Patch foraging water rate 0 sec1.43.03.6-1.8-1.7-1.71.7-1.7-1.7-1.9-1.6-1.6-1.8
Patch foraging water rate 12 sec0.20.30.70.50.60.6-0.60.60.60.20.60.80.3
Patch foraging water rate 18 sec0.40.60.70.90.80.8-0.80.80.80.50.80.80.6
Patch foraging water rate 24 sec0.20.30.7-0.4-0.5-0.50.5-0.5-0.5-0.8-0.5-0.5-0.9
Patch foraging water rate 6 sec1.01.52.0-1.3-1.2-1.21.2-1.2-1.1-1.4-1.1-1.1-1.4
Seeking ratio, delayed vs. immediate footshock2.12.53.3-1.5-1.6-1.61.6-1.6-1.6-1.5-1.6-1.8-1.4
Distance traveled before self-admin3.44.44.8-2.2-2.2-2.22.2-2.2-2.2-1.8-2.1-2.1-1.9
Distance traveled after self-admin0.10.10.1-0.3-0.3-0.30.3-0.3-0.4-0.1-0.4-0.3-0.2
Extensor digitorum longus weight0.72.83.21.81.71.7-1.71.71.71.61.71.61.6
Bone: elastic displacement3.03.53.7-1.9-1.9-1.91.9-1.9-1.9-1.9-1.8-1.8-1.9
Bone: elastic work8.711.312.7-3.4-3.3-3.33.3-3.3-3.2-3.6-3.3-3.2-3.6
Bone: endosteal estimation0.00.00.10.0-0.1-0.10.1-0.1-0.2-0.2-0.1-0.1-0.3
Bone: endosteal perimeter0.00.00.00.20.10.0-0.00.0-0.0-0.00.00.0-0.2
Epididymis fat weight7.726.429.45.45.35.2-5.25.25.15.05.15.04.7
Delta time in closed arm before/after self-admin3.02.83.0-1.7-1.7-1.71.7-1.7-1.6-1.6-1.7-1.6-1.6
Delta time in open arm before/after self-admin6.16.06.82.62.52.4-2.42.42.32.62.42.32.5
Diff in mean of infusions in LGA sessions0.50.70.70.80.80.8-0.80.80.80.80.80.80.7
Delay discount exponential model param1.61.82.11.01.21.4-1.31.31.41.31.41.41.4
Extinction: sum of active levers before priming1.11.21.41.01.11.1-1.11.11.21.11.11.11.2
Active lever presses in extinction session 60.40.40.80.40.50.7-0.60.70.80.60.80.90.7
Bone: final force0.40.60.8-0.7-0.7-0.70.7-0.7-0.8-0.8-0.8-0.8-0.9
Bone: final moment0.40.70.9-0.7-0.8-0.80.8-0.8-0.8-0.9-0.8-0.8-1.0
Food consumed during 24 hour testing period0.10.20.4-0.5-0.4-0.40.4-0.4-0.3-0.6-0.3-0.2-0.5
Glucose1.42.32.5-1.5-1.5-1.51.5-1.5-1.6-1.4-1.5-1.6-1.2
Heart weight1.72.63.11.51.61.7-1.71.71.81.31.61.71.3
Delay discount hyperbolic model param2.02.32.71.31.41.5-1.51.51.61.51.51.61.6
Intermittent access intake day 1-15 change0.10.10.50.20.20.2-0.20.20.10.60.30.20.7
Intermittent access intake escalation0.10.20.60.40.30.3-0.30.30.20.70.40.30.8
Intermittent access intake escalation 20.10.20.3-0.4-0.4-0.40.4-0.4-0.5-0.0-0.4-0.50.0
Intermitt. access day 1 inactive lever presses0.00.20.2-0.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.4-0.5
Intermitt. access day 15 inactive lever presses0.30.60.7-0.8-0.8-0.80.8-0.8-0.8-0.8-0.8-0.7-0.8
Intermitt. access escalation Index0.70.91.41.21.11.0-1.01.00.90.71.00.90.8
Intermittent access day 1 total infusions0.10.10.20.50.40.3-0.30.30.20.10.30.20.3
Intermittent access day 15 total infusions0.71.11.91.11.01.0-1.01.00.81.11.00.81.4
Intermittent access terminal intake (last 3 days)0.91.21.91.21.11.0-1.01.00.91.11.00.91.4
Intermittent access total infusions0.30.31.00.70.60.5-0.50.50.30.60.60.31.0
Intermittent access day 1 locomotion0.00.00.00.20.10.0-0.00.0-0.0-0.0-0.0-0.10.2
Intermittent access day 15 total locomotion0.30.51.00.70.70.6-0.60.60.50.90.70.51.0
Intermittent access total locomotion0.50.61.20.80.80.7-0.70.70.61.00.70.61.1
Intermittent access standard deviation0.00.00.10.1-0.0-0.10.1-0.1-0.2-0.1-0.1-0.30.2
Left kidney weight0.00.20.30.50.50.5-0.50.50.60.10.40.40.0
Right kidney weight0.10.60.70.90.80.8-0.80.80.80.60.80.70.5
Cocaine induced anxiety0.20.20.4-0.4-0.4-0.40.4-0.4-0.5-0.7-0.4-0.4-0.7
Post-drug Anxiety0.20.30.30.40.40.5-0.50.50.50.60.50.60.6
Baseline Anxiety0.50.61.20.50.60.7-0.70.70.81.10.70.71.1
Tail length0.51.81.91.41.41.4-1.31.41.41.41.41.31.0
Length with tail0.52.32.81.71.61.6-1.61.61.61.41.51.51.1
Length without tail0.30.91.41.21.11.0-1.01.00.90.70.80.90.7
Times rat made contact with spout0.00.00.1-0.2-0.2-0.10.1-0.10.0-0.0-0.0-0.0-0.1
Lifetime Intake0.40.51.00.90.70.6-0.60.60.40.80.70.41.0
Liver weight, left5.08.28.62.92.92.9-2.92.92.72.92.92.82.9
Liver weight, right3.96.77.12.72.72.6-2.62.62.62.52.62.62.4
Locomotor activity0.00.00.1-0.1-0.2-0.20.2-0.2-0.3-0.3-0.2-0.2-0.2
Locomotor testing distance0.10.10.2-0.3-0.3-0.40.4-0.3-0.4-0.3-0.4-0.4-0.2
Locomotor testing rearing0.00.00.1-0.3-0.2-0.20.2-0.2-0.10.1-0.2-0.20.0
Locomotion in novel chamber2.73.43.9-1.8-1.8-1.91.9-1.9-1.9-1.9-2.0-2.0-1.3
Locomotion in novel chamber post-restriction0.10.10.50.00.00.0-0.0-0.00.10.5-0.1-0.30.7
Fecal boli incidents, locomotor time 11.72.43.11.41.51.5-1.51.51.61.61.61.51.7
Change in fecal boli incidents, locomotor task0.30.30.4-0.2-0.4-0.50.5-0.5-0.6-0.6-0.6-0.5-0.7
Time >=10cm from walls, locomotor time 10.00.00.10.20.20.1-0.10.10.20.20.20.20.3
Bouts of movement, locomotor time 10.50.60.8-0.7-0.7-0.70.7-0.7-0.8-0.8-0.8-0.8-0.9
Total resting periods, locomotor time 10.10.10.2-0.4-0.3-0.30.3-0.3-0.3-0.4-0.3-0.3-0.5
Rest time, locomotor task time 10.30.30.60.40.50.5-0.50.50.60.60.50.60.8
Distance moved, locomotor task time 10.40.60.8-0.6-0.7-0.70.7-0.7-0.8-0.9-0.8-0.8-0.9
Vertical activity count, locomotor time 10.10.30.4-0.2-0.4-0.50.5-0.5-0.6-0.6-0.6-0.6-0.6
Time >=10cm from walls, locomotor time 20.71.01.41.21.01.0-1.01.01.00.91.01.01.0
Bouts of movement, locomotor time 20.30.40.8-0.7-0.6-0.60.6-0.6-0.6-0.8-0.6-0.4-0.9
Total resting periods, locomotor time 20.00.10.2-0.3-0.3-0.20.3-0.3-0.2-0.3-0.2-0.1-0.5
Rest time, locomotor task time 20.10.10.4-0.20.00.2-0.20.20.40.60.30.30.6
Distance moved, locomotor task time 20.50.61.0-0.4-0.6-0.80.7-0.7-0.9-1.0-0.9-0.9-0.8
Vertical activity count, locomotor time 20.81.11.7-0.4-0.7-1.00.9-0.9-1.2-1.3-1.2-1.2-1.2
Light reinforcement 10.00.00.1-0.1-0.1-0.20.2-0.2-0.2-0.3-0.2-0.2-0.1
Light reinforcement 20.40.60.8-0.7-0.7-0.80.8-0.8-0.7-0.9-0.7-0.8-0.8
Bone: marrow area0.00.00.1-0.0-0.1-0.10.1-0.1-0.2-0.2-0.1-0.1-0.4
Bone: maximum diameter0.40.81.2-0.7-0.8-0.90.8-0.8-0.9-1.0-0.9-0.9-1.1
Bone: maximum force0.61.01.4-0.9-1.0-1.01.0-1.0-1.0-1.1-1.0-1.0-1.2
Bone: maximum moment0.71.31.6-1.0-1.1-1.11.1-1.1-1.1-1.2-1.1-1.1-1.3
Mean time between licks in bursts0.30.91.01.01.00.9-0.90.91.00.90.90.90.9
Mean num. licks in bursts0.30.40.50.60.70.7-0.70.70.70.60.70.70.6
Cd content in liver0.91.01.2-0.9-0.9-1.01.0-1.0-1.0-1.0-1.0-0.9-1.1
Co content in liver0.30.40.5-0.6-0.6-0.60.6-0.6-0.6-0.6-0.7-0.7-0.5
Cu content in liver1.41.72.1-1.5-1.4-1.31.3-1.3-1.3-1.1-1.2-1.2-1.5
Fe content in liver2.12.52.61.61.61.6-1.61.61.61.41.61.61.6
K content in liver0.10.10.10.40.30.3-0.30.30.20.40.30.30.3
Mg content in liver0.60.60.7-0.8-0.8-0.80.8-0.8-0.7-0.8-0.7-0.7-0.8
Mn content in liver0.20.20.3-0.5-0.5-0.40.5-0.5-0.4-0.5-0.4-0.4-0.4
Na content in liver0.00.00.10.30.20.0-0.10.1-0.10.2-0.0-0.20.1
Rb content in liver0.10.10.10.30.30.3-0.30.30.20.10.20.20.3
Se content in liver0.60.70.8-0.9-0.8-0.80.8-0.8-0.8-0.8-0.7-0.7-0.8
Sr content in liver0.50.40.40.70.70.7-0.70.70.70.60.60.60.7
Zn content in liver0.40.40.40.60.60.7-0.60.60.70.60.60.70.5
Bone: minimum diameter0.10.20.3-0.3-0.4-0.40.4-0.4-0.3-0.5-0.5-0.4-0.6
Time in familiar zone, hab. session 10.40.40.5-0.5-0.6-0.60.6-0.6-0.6-0.5-0.6-0.7-0.7
Time in novel zone, hab. session 10.20.20.30.40.40.4-0.40.40.50.40.50.50.5
Total zone transitions, hab. session 10.10.10.1-0.2-0.2-0.30.3-0.3-0.3-0.4-0.3-0.3-0.4
Total locomotion distance, hab. session 10.10.10.3-0.3-0.3-0.30.3-0.3-0.3-0.5-0.3-0.3-0.4
Locomotion velocity, hab. session 10.30.50.8-0.7-0.7-0.70.7-0.7-0.7-0.9-0.7-0.6-0.7
Time in familiar zone, hab. session 20.10.10.2-0.4-0.4-0.30.3-0.3-0.3-0.3-0.3-0.3-0.2
Time in novel zone, hab. session 20.20.20.3-0.3-0.4-0.40.4-0.4-0.5-0.5-0.5-0.5-0.5
Total zone transitions, hab. session 20.20.30.30.60.60.6-0.60.60.60.60.60.50.5
Total locomotion distance, hab. session 20.00.10.1-0.3-0.3-0.20.2-0.2-0.2-0.3-0.2-0.2-0.2
Locomotion velocity, hab. session 20.10.10.1-0.4-0.3-0.30.3-0.3-0.2-0.3-0.2-0.2-0.3
Novel to familiar place preference ratio0.80.91.01.01.00.9-0.90.90.90.90.90.90.9
Novelty place preference1.11.11.31.11.11.1-1.11.11.11.01.11.11.0
Time in novel zone, NPP test1.21.21.31.21.11.1-1.11.11.11.01.11.11.1
Total zone transitions, NPP test0.00.00.00.10.10.1-0.10.10.1-0.00.10.10.0
Total locomotion distance, NPP test0.81.21.4-1.1-1.1-1.11.1-1.1-1.0-1.2-1.0-1.0-1.1
Locomotion velocity, NPP test1.01.41.7-1.2-1.2-1.21.2-1.2-1.2-1.3-1.2-1.1-1.2
Intraocular pressure1.11.51.7-1.3-1.3-1.31.3-1.3-1.3-1.2-1.2-1.2-1.1
Delta distance traveled before/after self-admin3.03.23.41.91.81.8-1.81.81.81.61.81.81.7
Delta ambulatory time before/after self-admin2.02.52.91.71.61.6-1.61.61.61.51.61.51.5
Parametrial fat weight6.314.715.53.93.93.9-3.93.93.93.83.83.83.6
Pavlov. Cond. lever latency0.00.00.00.10.10.2-0.20.20.20.10.20.20.0
Pavlov. Cond. magazine entry latency0.00.00.00.10.10.1-0.10.10.10.10.10.10.1
Pavlov. Cond. change in total contacts0.30.30.4-0.6-0.6-0.60.6-0.6-0.6-0.4-0.6-0.6-0.4
Pavlov. Cond. index score0.00.00.1-0.1-0.2-0.20.2-0.2-0.2-0.1-0.2-0.3-0.1
Pavlov. Cond. latency score0.00.00.0-0.0-0.0-0.10.1-0.1-0.1-0.0-0.1-0.10.1
Pavlov. Cond. lever contacts0.00.00.0-0.0-0.1-0.10.1-0.1-0.2-0.1-0.2-0.20.1
Pavlov. Cond. magazine entry number0.20.20.20.40.40.4-0.40.40.50.40.50.50.4
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.5-0.5-0.50.5-0.5-0.4-0.5-0.4-0.4-0.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.3-0.3-0.30.3-0.3-0.4-0.2-0.4-0.4-0.2
Pavlov. Cond. response bias0.00.00.0-0.1-0.1-0.10.1-0.1-0.2-0.1-0.2-0.2-0.1
Pavlov. Cond. lever latency2.63.53.71.91.91.9-1.91.91.91.91.81.81.8
Pavlov. Cond. magazine entry latency0.20.30.3-0.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.5-0.4
Pavlov. Cond. change in total contacts1.32.12.4-1.5-1.5-1.51.5-1.5-1.5-1.5-1.4-1.4-1.4
Pavlov. Cond. index score2.33.03.2-1.8-1.8-1.81.8-1.8-1.8-1.7-1.7-1.7-1.7
Pavlov. Cond. latency score2.63.53.8-1.9-1.9-1.91.9-1.9-1.9-1.8-1.8-1.9-1.8
Pavlov. Cond. lever contacts1.31.92.1-1.5-1.4-1.41.4-1.4-1.4-1.4-1.3-1.3-1.3
Pavlov. Cond. magazine entry number0.00.00.00.20.20.2-0.20.20.20.10.10.20.1
Pavlov. Cond. intertrial magazine entries0.40.70.80.80.80.8-0.80.80.90.80.80.90.8
Pavlov. Cond. lever-magazine prob. diff.1.72.32.4-1.6-1.5-1.51.5-1.5-1.6-1.5-1.5-1.5-1.4
Pavlov. Cond. response bias1.21.61.8-1.3-1.3-1.31.3-1.3-1.3-1.3-1.2-1.2-1.2
Time in closed arm before self-admin1.21.62.31.41.31.2-1.21.21.11.51.21.01.4
Time in closed arm after self-admin1.11.11.6-0.8-1.0-1.11.1-1.1-1.2-0.9-1.2-1.2-1.1
Time in open arm before self-admin1.61.72.4-1.5-1.4-1.21.3-1.3-1.1-1.6-1.2-1.0-1.4
Time in open arm after self-admin1.11.21.21.11.11.1-1.11.11.11.11.11.11.1
Bone: periosteal estimation0.51.01.5-0.8-0.9-0.90.9-0.9-1.0-1.1-1.0-0.9-1.2
Bone: periosteal perimeter0.40.71.2-0.6-0.7-0.80.8-0.8-0.8-0.9-0.9-0.8-1.1
Bone: post-yield work0.20.30.40.60.60.5-0.50.50.50.60.50.40.6
Progressive ratio test 1 active lever presses0.50.61.0-0.7-0.8-0.90.8-0.8-1.0-0.6-0.8-1.0-0.4
Progressive ratio test 1 breakpoint0.60.71.1-0.7-0.8-0.90.9-0.9-1.0-0.7-0.9-1.0-0.5
Progressive ratio test 1 inactive lever presses1.82.63.2-1.4-1.5-1.61.6-1.6-1.8-1.7-1.6-1.7-1.5
Progressive ratio test 2 active lever presses0.30.40.5-0.6-0.6-0.60.6-0.6-0.7-0.5-0.6-0.7-0.4
Progressive ratio test 2 breakpoint0.30.30.4-0.6-0.6-0.60.6-0.6-0.6-0.4-0.5-0.6-0.3
Progressive ratio test 2 inactive lever presses0.10.10.2-0.3-0.4-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4
Incentive Sensitization - Responses0.00.00.10.00.10.1-0.10.10.20.10.20.30.1
Incentive Sensitization - Breakpoint0.00.00.10.10.10.2-0.20.20.20.20.30.30.2
Sum of active levers in priming session hrs 5-61.71.61.71.21.31.3-1.31.31.31.31.31.31.2
Progressive ratio0.10.10.30.10.20.3-0.30.30.40.20.50.50.5
Food seeking constrained by brief footshock0.10.10.20.30.30.3-0.30.30.40.40.30.40.2
Seeking ratio, punishment vs. effort0.10.20.4-0.2-0.3-0.50.4-0.5-0.5-0.2-0.6-0.7-0.5
Retroperitoneal fat weight0.51.92.51.61.51.4-1.41.41.31.41.31.21.2
Reaction time number correct0.71.31.41.21.21.1-1.21.21.21.01.11.21.0
Reaction time mean minus median0.10.30.50.50.60.6-0.60.60.60.60.60.60.7
Reaction time mean minus median AUC0.92.32.71.51.51.5-1.51.51.51.61.41.41.6
Reaction time num false alarms5.67.98.4-2.9-2.8-2.82.8-2.8-2.9-2.9-2.7-2.7-2.7
Reaction time num false alarms AUC5.18.08.7-2.9-2.9-2.82.8-2.8-2.9-2.9-2.7-2.7-2.8
Reaction time trials correct on left0.71.31.41.21.21.1-1.21.21.21.01.11.21.0
Reaction time trials on left0.71.31.41.21.21.2-1.21.21.21.01.11.21.0
Reaction time mean0.71.11.31.01.01.1-1.11.11.10.91.01.01.0
Reaction time mean AUC0.50.81.00.90.90.9-0.90.91.00.80.90.90.8
Median of all reaction times0.50.70.90.80.90.9-0.90.91.00.70.90.90.8
Reaction time omissions1.21.72.11.31.31.3-1.31.31.21.31.31.31.5
Reaction time false alarm rate6.08.38.7-2.9-2.9-2.92.9-2.9-3.0-2.9-2.8-2.8-2.8
Reaction time premature initiation rate0.10.20.30.50.50.4-0.40.40.30.40.30.40.4
Reaction time premature initiations0.30.50.70.80.80.7-0.70.70.70.70.60.70.6
Std. dev. reaction times0.71.31.41.11.11.1-1.11.11.11.11.11.11.2
Reaction time trials completed0.71.31.41.21.21.2-1.21.21.21.01.11.21.0
Reaction time trials AUC0.61.11.21.11.11.1-1.11.11.10.91.01.10.9
Run reversals in cocaine runway, females0.10.10.10.30.30.2-0.20.30.3-0.10.30.4-0.2
Run reversals in cocaine runway, males0.10.10.30.30.20.2-0.20.20.20.20.1-0.10.6
Latency to leave start box in cocaine runway0.10.20.6-0.8-0.5-0.30.4-0.3-0.1-0.5-0.10.1-0.4
Latency to leave start box in cocaine runway, F0.00.00.1-0.3-0.10.0-0.00.00.2-0.10.20.3-0.1
Latency to leave start box in cocaine runway, M0.10.10.3-0.5-0.4-0.20.2-0.2-0.1-0.4-0.10.1-0.2
Std. dev. time between licks in bursts0.00.00.00.20.10.1-0.10.10.10.20.1-0.0-0.0
Total sessions with >9 infusions0.10.20.50.70.50.4-0.40.40.20.30.30.20.4
Short access day 1 total inactive lever presses2.93.84.92.22.01.9-1.91.91.72.11.91.82.0
Short access day 10 total inactive lever presses0.00.00.1-0.0-0.1-0.20.2-0.2-0.20.1-0.3-0.3-0.1
Short access day 1 total infusions0.30.40.91.00.80.6-0.60.60.50.70.50.40.7
Short access day 10 total infusions0.20.20.50.70.50.4-0.40.40.30.40.40.20.5
Short access total infusions0.10.10.20.50.30.1-0.20.2-0.10.40.1-0.10.4
Short access day 1 locomotion0.10.10.2-0.0-0.1-0.30.2-0.2-0.3-0.4-0.4-0.4-0.2
Short access day 10 total locomotion0.40.70.9-0.8-0.8-0.90.9-0.9-0.9-0.9-0.8-1.0-0.7
Short access total locomotion0.60.81.1-0.6-0.8-0.90.9-0.9-1.0-1.0-0.9-1.0-0.8
One hour access (0.3 mA shock)0.10.10.3-0.2-0.3-0.40.4-0.3-0.50.2-0.2-0.40.1
Compulsive drug intake0.91.11.71.11.01.0-1.01.01.01.31.01.00.9
One hour access (shock baseline)0.10.20.4-0.4-0.4-0.50.5-0.5-0.6-0.3-0.3-0.6-0.0
Social response proportion2.12.43.01.71.61.6-1.61.61.51.71.51.41.4
Social responses1.92.42.71.61.61.6-1.61.61.51.51.61.51.5
Social time1.41.92.71.51.41.3-1.31.31.31.71.21.11.5
Soleus weight2.26.56.82.62.62.6-2.62.62.62.52.52.42.5
Bone: stiffness1.82.93.31.81.81.7-1.71.71.71.61.61.61.7
Tibialis anterior weight2.89.49.63.13.13.1-3.13.13.13.13.03.02.9
Time to tail flick, vehicle, before self-admin0.00.00.10.30.20.1-0.10.10.00.10.1-0.00.0
Time to tail flick, vehicle, after self-admin0.40.60.8-0.6-0.7-0.80.8-0.8-0.8-0.6-0.8-0.9-0.7
Time to tail flick, test, before self-admin0.00.00.10.00.10.1-0.10.10.10.30.20.00.2
Time to tail flick, test, after self-admin0.10.10.6-0.8-0.5-0.30.4-0.4-0.2-0.1-0.1-0.1-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.7-0.6-0.50.5-0.5-0.4-0.5-0.5-0.4-0.4
Delta time to tail flick, test, before/after SA0.40.40.5-0.7-0.7-0.60.6-0.6-0.6-0.6-0.6-0.5-0.6
Tibia length0.00.10.1-0.2-0.3-0.30.3-0.3-0.3-0.4-0.3-0.3-0.3
Ambulatory time before self-admin1.72.62.9-1.5-1.5-1.61.6-1.6-1.7-1.5-1.7-1.7-1.6
Ambulatory time after self-admin0.00.00.00.10.0-0.00.0-0.0-0.00.0-0.00.0-0.0
Bone: tissue strength1.81.82.0-1.3-1.3-1.41.3-1.4-1.3-1.3-1.4-1.4-1.4
Total heroin consumption4.14.85.91.92.12.3-2.22.22.41.92.32.42.1
Bone: trabecular number3.25.35.72.22.32.3-2.32.32.32.42.42.32.4
Bone: trabecular spacing0.30.40.5-0.6-0.6-0.60.6-0.6-0.7-0.6-0.7-0.7-0.6
Bone: trabecular thickness0.00.00.0-0.0-0.0-0.10.1-0.1-0.0-0.2-0.1-0.0-0.2
Bone: trabecular tissue density1.31.92.2-1.4-1.4-1.41.4-1.4-1.4-1.3-1.4-1.4-1.5
Water consumed over 24 hours0.00.00.1-0.1-0.1-0.10.1-0.1-0.1-0.2-0.1-0.1-0.3
Number of responses in last shaping day1.31.42.1-1.1-1.1-1.21.2-1.2-1.0-1.1-1.3-1.2-1.4