Hub : Genes

Ndufb5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Ndufb5 0.02 0.02 4.7e-04 0.01 0.03 0.02 0.02 1.2e-02 5.5e-04 4.1e-03 1.5e-03
2 BLA gene expression Ndufb5 0.19 0.12 2.0e-05 0.06 0.09 0.07 0.06 4.0e-04 1.5e-05 2.1e-04 3.7e-04
3 pVTA gene expression Ndufb5 0.09 0.06 2.7e-04 0.02 0.08 0.06 0.05 3.4e-02 3.6e-04 2.2e-03 2.8e-03
4 RMTg gene expression Ndufb5 0.11 0.08 4.4e-03 0.04 0.06 0.04 0.05 3.2e-02 1.4e-02 2.7e-02 2.0e-02
5 BLA mRNA stability Ndufb5 0.06 0.05 3.0e-03 0.03 0.03 0.03 0.03 9.7e-03 6.1e-03 1.3e-02 1.0e-02
6 Brain mRNA stability Ndufb5 0.24 0.1 0.0e+00 0.21 0.22 0.21 0.21 2.7e-19 7.3e-20 4.7e-19 2.0e-19
7 PL gene expression Ndufb5 0.07 0.05 6.7e-05 0.06 0.04 0.04 0.05 8.2e-07 3.4e-05 2.3e-05 7.1e-06
8 Adipose gene expression Ndufb5 0.09 0.05 1.0e-08 0.08 0.05 0.06 0.07 6.3e-09 5.3e-06 8.8e-07 2.9e-08
9 Adipose mRNA stability Ndufb5 0.05 0.03 2.5e-04 0.03 0.03 0.02 0.03 1.4e-04 4.7e-04 6.1e-03 1.9e-04
10 Brain gene expression Ndufb5 0.05 0.04 5.5e-04 0.03 0.02 0.03 0.03 6.8e-04 3.2e-03 2.0e-03 2.0e-03
11 Eye gene expression Ndufb5 0.63 0.2 2.8e-03 0.17 0.07 0.03 0.1 1.5e-03 3.5e-02 1.1e-01 1.2e-02
12 PL mRNA stability Ndufb5 0.11 0.07 5.5e-08 0.07 0.07 0.07 0.07 2.1e-08 2.5e-08 3.8e-08 6.5e-08
13 NAcc gene expression Ndufb5 0.08 0.06 2.6e-04 0.02 0.02 0.02 0.03 4.1e-03 7.1e-04 1.1e-03 6.7e-04
14 Liver gene expression Ndufb5 0.22 0.11 6.2e-15 0.11 0.11 0.12 0.1 7.8e-12 1.9e-12 4.0e-13 1.9e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.83.17.8-2.32.82.42.2-2.2-1.5-1.2-1.31.3-1.2-1.31.31.2-1.0
Area under the delay curve1.21.31.8-1.20.81.11.3-1.2-1.2-1.1-1.11.1-1.4-1.11.11.2-1.1
BMI with tail0.82.53.2-1.61.81.81.6-1.7-1.4-1.6-1.61.4-1.7-1.41.41.6-1.3
BMI without tail1.42.83.5-1.91.61.91.9-1.9-1.7-1.5-1.71.7-1.4-1.71.71.7-1.3
Body weight0.00.10.3-0.10.30.20.1-0.2-0.1-0.2-0.10.3-0.6-0.10.10.3-0.2
Weight adjusted by age2.22.53.41.5-0.8-1.4-1.61.51.71.71.7-1.61.81.5-1.5-1.61.8
Bone surface0.20.41.4-0.11.20.4-0.0-0.00.60.90.9-0.70.60.7-0.7-0.60.7
Bone volume0.30.52.1-0.31.40.50.2-0.10.50.80.8-0.70.60.7-0.7-0.70.8
Breakpoint value in progressive ratio session4.54.96.4-2.21.92.32.1-2.4-2.2-2.4-2.52.3-2.1-2.22.22.2-2.1
Number of licking bursts3.33.85.2-1.70.91.61.8-1.9-2.1-2.1-1.92.2-1.9-2.32.32.1-2.3
Context. condit. distance diff. score1.61.95.3-1.92.31.91.8-1.7-1.2-0.9-0.91.0-0.9-1.01.00.9-0.4
Locomotion velocity, session 10.30.30.90.9-1.0-0.8-0.90.50.3-0.1-0.1-0.0-0.20.1-0.10.1-0.5
Locomotion distance, session 10.20.20.80.2-0.4-0.1-0.2-0.0-0.2-0.7-0.70.4-0.8-0.40.40.6-0.9
Locomotion velocity, session 20.40.51.91.0-1.4-0.9-1.00.50.1-0.4-0.40.2-0.3-0.20.20.2-0.8
Locomotion distance, session 20.20.20.70.8-0.7-0.7-0.80.60.4-0.2-0.2-0.3-0.10.2-0.2-0.1-0.2
Locomotion velocity, session 30.00.00.10.00.10.1-0.1-0.00.0-0.1-0.10.0-0.1-0.10.1-0.0-0.2
Locomotion distance, session 30.10.10.50.2-0.7-0.3-0.20.1-0.2-0.5-0.30.3-0.1-0.30.30.2-0.4
Stereotopy head waving bouts, day 30.00.00.00.2-0.1-0.2-0.20.10.1-0.1-0.1-0.1-0.20.1-0.1-0.1-0.1
Stereotopy head waving duration, day 30.70.81.0-0.90.91.00.9-0.9-0.8-1.0-1.00.8-1.0-0.80.80.8-0.9
Locomotion velocity, session 70.80.81.40.90.2-0.6-1.00.81.20.70.9-1.10.91.1-1.1-1.00.7
Locomotion distance, session 70.71.01.31.0-0.5-0.9-1.11.01.10.70.8-1.11.11.1-1.1-1.11.0
Stereotopy head waving bouts, day 72.83.24.0-1.60.91.61.7-1.8-1.9-1.9-2.02.0-2.0-1.91.91.9-1.7
Stereotopy head waving duration, day 72.63.23.7-1.71.21.71.7-1.8-1.8-1.8-1.91.9-1.9-1.91.91.8-1.7
Locomotion velocity, session 82.73.23.7-1.81.61.91.8-1.9-1.8-1.7-1.81.8-1.9-1.81.81.8-1.7
Locomotion distance, session 80.30.42.0-0.81.40.90.7-0.7-0.3-0.3-0.20.1-0.5-0.20.20.3-0.0
Degree of sensitization distance2.22.23.01.2-0.5-1.2-1.31.41.61.71.6-1.61.71.6-1.6-1.61.7
Degree of sensitization stereotypy3.33.64.2-1.81.11.71.9-1.9-2.0-2.0-2.12.0-2.0-2.02.02.0-1.8
Conditioned locomotion0.40.51.40.2-0.1-0.3-0.20.40.51.00.9-0.60.80.7-0.7-0.91.2
Cocaine response after cond. corrected0.30.30.60.4-0.7-0.6-0.30.60.40.50.6-0.60.30.6-0.6-0.60.8
Cocaine response after cond. not corrected0.91.01.20.9-1.0-1.0-0.81.10.91.11.1-1.10.81.1-1.1-1.01.0
Cocaine response before conditioning0.10.10.30.20.40.0-0.30.10.40.60.5-0.30.60.4-0.4-0.3-0.1
Saline control response1.11.42.01.1-0.2-0.9-1.21.11.41.01.4-1.41.31.4-1.4-1.30.9
Bone: connectivity density1.52.44.0-1.82.01.91.7-1.8-1.5-1.2-1.31.4-1.0-1.51.51.2-1.1
Bone: cortical apparent density0.00.00.2-0.10.30.20.1-0.2-0.0-0.2-0.20.10.4-0.10.1-0.10.2
Bone: cortical area0.91.43.20.41.0-0.2-0.60.61.31.21.3-1.51.81.4-1.4-1.41.4
Bone: cortical porosity0.00.00.2-0.10.00.10.10.0-0.0-0.3-0.2-0.0-0.10.0-0.0-0.1-0.4
Bone: cortical porosity0.10.10.20.00.50.1-0.00.10.30.10.1-0.40.20.4-0.4-0.4-0.1
Bone: cortical thickness0.50.82.40.11.00.1-0.20.30.90.70.9-1.11.51.0-1.0-1.11.0
Bone: cortical thickness0.20.30.80.1-0.5-0.0-0.0-0.2-0.5-0.6-0.50.6-0.7-0.50.50.6-0.9
Bone: cortical tissue density0.00.00.1-0.20.30.20.1-0.2-0.1-0.3-0.30.20.3-0.10.1-0.00.1
Condit. Reinf. active minus inactive responses1.21.42.11.4-1.1-1.3-1.51.31.21.11.1-1.21.11.1-1.1-1.00.6
Condit. Reinf. active-inactive response ratio1.81.92.21.5-1.2-1.5-1.51.51.41.51.4-1.41.41.3-1.3-1.31.1
Condit. Reinf. active responses0.40.41.00.9-0.1-0.6-1.00.70.90.30.5-0.70.60.7-0.7-0.5-0.0
Condit. Reinf. inactive responses0.50.51.9-0.51.40.90.4-0.8-0.3-1.1-0.60.4-0.6-0.40.40.6-1.1
Incentive salience index mean1.41.72.61.6-1.2-1.5-1.61.51.41.21.2-1.31.11.3-1.3-1.10.7
Condit. Reinf. lever presses0.30.40.90.9-0.3-0.7-0.90.80.80.40.4-0.80.30.8-0.8-0.5-0.0
Condit. Reinf. active minus inactive responses1.21.52.11.4-0.6-1.2-1.41.31.41.21.2-1.31.31.3-1.3-1.30.8
Condit. Reinf. active-inactive response ratio1.51.61.91.3-1.1-1.3-1.31.41.31.21.2-1.21.21.2-1.2-1.41.1
Condit. Reinf. active responses2.02.84.32.0-0.9-1.7-2.11.82.01.51.5-1.81.61.8-1.8-1.60.8
Condit. Reinf. inactive responses0.40.51.41.1-0.7-0.9-1.20.80.80.40.3-0.60.50.6-0.6-0.4-0.2
Condit. Reinf. lever presses0.30.50.60.6-0.1-0.5-0.70.60.80.80.8-0.80.70.8-0.8-0.60.5
Condit. Reinf. lever reinforcers received1.92.64.11.9-0.8-1.6-2.01.71.91.41.4-1.81.61.8-1.8-1.60.8
Conditioned reinforcement - actives0.20.20.70.6-0.8-0.7-0.60.50.3-0.1-0.2-0.20.40.2-0.2-0.2-0.3
Conditioned reinforcement - inactives0.10.10.80.1-0.2-0.1-0.00.0-0.1-0.6-0.90.0-0.2-0.10.10.2-0.5
Conditioned locomotion0.20.31.10.3-0.3-0.1-0.3-0.1-0.2-1.0-1.00.5-0.4-0.50.50.5-0.9
Patch foraging indifference point 0 sec1.42.32.9-1.71.31.61.6-1.7-1.6-1.6-1.41.6-1.4-1.51.51.5-1.2
Patch foraging indifference point AUC3.13.55.0-1.60.91.61.6-1.8-2.0-2.0-2.02.0-2.2-1.91.92.2-2.2
Delay disc. indifference point, 0s delay0.20.20.40.6-0.2-0.5-0.60.50.60.20.4-0.60.30.5-0.5-0.50.1
Delay disc. indifference point, 16s delay1.31.31.7-1.31.21.31.3-1.3-1.1-1.2-1.11.1-0.9-1.11.11.0-0.9
Delay disc. indifference point, 2s delay0.40.40.6-0.80.80.80.8-0.7-0.5-0.5-0.50.5-0.8-0.50.50.6-0.5
Delay disc. indifference point, 24s delay0.80.81.4-1.21.01.11.1-1.1-0.9-0.7-0.80.9-0.5-0.80.80.7-0.4
Delay disc. indifference point, 4s delay0.60.61.5-0.60.30.60.7-0.7-0.8-0.9-0.80.7-1.2-0.70.70.9-1.1
Delay disc. indifference point, 8s delay0.40.41.0-0.6-0.10.40.6-0.5-0.7-0.6-0.60.6-1.0-0.60.60.7-0.6
Indifference point function ln k2.73.85.51.6-1.2-1.7-1.61.92.02.22.2-2.12.01.9-1.9-2.22.4
Indifference point function log k2.73.85.51.6-1.2-1.7-1.61.92.02.22.2-2.12.01.9-1.9-2.22.4
Patch foraging total patch changes 0 sec1.52.53.0-1.71.31.71.7-1.7-1.7-1.6-1.41.7-1.5-1.61.61.6-1.3
Patch foraging total patch changes 12 sec2.53.34.7-1.81.11.71.8-1.9-2.0-2.2-1.81.9-1.8-1.71.72.0-1.8
Patch foraging total patch changes 18 sec2.63.34.4-1.70.91.61.7-1.8-2.0-2.0-1.82.0-2.0-1.91.92.1-1.8
Patch foraging total patch changes 24 sec6.27.59.1-2.92.73.02.9-3.0-2.7-2.6-2.62.7-2.8-2.52.52.8-2.5
Patch foraging total patch changes 6 sec5.88.610.1-3.12.43.13.1-3.2-3.1-3.0-2.83.1-2.9-2.72.73.1-2.8
Patch foraging time to switch 0 sec0.20.30.60.4-0.3-0.5-0.40.50.60.40.6-0.70.80.7-0.7-0.70.7
Patch foraging water rate 0 sec0.40.60.8-0.90.90.90.9-0.8-0.7-0.6-0.60.7-0.8-0.70.70.8-0.5
Patch foraging water rate 12 sec0.00.00.20.10.1-0.1-0.10.20.30.10.1-0.20.40.2-0.2-0.30.3
Patch foraging water rate 18 sec0.00.10.10.2-0.3-0.2-0.20.1-0.00.0-0.30.1-0.4-0.20.20.2-0.3
Patch foraging water rate 24 sec1.62.23.9-1.62.01.81.5-1.7-1.3-1.2-1.31.4-1.3-1.41.41.3-1.2
Patch foraging water rate 6 sec0.00.10.2-0.20.10.20.2-0.2-0.3-0.3-0.30.4-0.2-0.30.30.2-0.3
Seeking ratio, delayed vs. immediate footshock0.20.31.0-0.61.00.70.6-0.6-0.3-0.3-0.30.30.3-0.50.50.2-0.3
Distance traveled before self-admin1.41.52.3-1.51.51.51.5-1.4-1.2-1.1-1.31.1-1.0-1.01.01.1-0.7
Distance traveled after self-admin1.11.21.9-1.00.71.01.0-1.1-1.2-1.3-1.41.2-1.0-1.11.11.1-1.0
Extensor digitorum longus weight0.21.01.7-0.71.21.00.7-1.0-0.8-1.1-1.30.9-0.8-0.80.80.9-1.2
Bone: elastic displacement0.20.20.40.2-0.4-0.4-0.20.40.30.50.3-0.40.60.4-0.4-0.60.6
Bone: elastic work2.43.04.51.4-0.3-1.2-1.41.52.01.91.7-2.12.02.0-2.0-2.11.9
Bone: endosteal estimation0.81.82.91.20.3-0.8-1.31.11.61.71.5-1.61.01.6-1.6-1.31.2
Bone: endosteal perimeter0.51.01.61.1-0.5-1.0-1.11.01.11.21.2-1.10.81.0-1.0-0.90.8
Epididymis fat weight0.61.31.81.3-0.9-1.2-1.31.21.21.31.3-1.10.71.3-1.3-0.81.0
Delta time in closed arm before/after self-admin0.20.21.1-0.21.00.40.1-0.10.40.40.5-0.40.20.4-0.4-0.40.4
Delta time in open arm before/after self-admin0.20.22.00.4-1.4-0.7-0.30.4-0.20.1-0.10.3-0.2-0.30.30.2-0.2
Diff in mean of infusions in LGA sessions0.10.11.0-0.31.00.50.3-0.30.20.10.2-0.20.10.2-0.2-0.20.5
Delay discount exponential model param1.51.52.11.3-0.8-1.2-1.41.31.31.21.2-1.21.51.2-1.2-1.31.2
Extinction: sum of active levers before priming0.30.31.00.40.2-0.3-0.50.40.70.40.5-0.61.00.6-0.6-0.80.6
Active lever presses in extinction session 60.10.10.3-0.30.30.40.3-0.4-0.3-0.4-0.60.4-0.1-0.30.30.3-0.5
Bone: final force1.11.83.10.90.7-0.5-1.10.91.61.51.5-1.61.71.6-1.6-1.41.2
Bone: final moment1.01.73.30.81.0-0.4-0.90.81.61.41.4-1.61.81.6-1.6-1.41.3
Food consumed during 24 hour testing period0.10.10.30.1-0.1-0.2-0.20.20.30.20.5-0.30.30.3-0.3-0.20.5
Glucose1.42.14.01.7-2.0-1.8-1.61.71.31.41.3-1.21.11.2-1.2-1.41.2
Heart weight0.20.31.5-0.61.20.80.6-0.6-0.3-0.6-0.60.2-0.3-0.20.20.2-0.5
Delay discount hyperbolic model param1.01.11.71.1-0.7-1.0-1.11.01.11.01.0-1.01.30.9-0.9-1.01.0
Intermittent access intake day 1-15 change2.02.03.3-1.10.51.11.2-1.3-1.5-1.6-1.81.5-1.4-1.51.51.6-1.7
Intermittent access intake escalation1.51.52.6-0.90.20.91.0-1.0-1.3-1.4-1.61.3-1.3-1.31.31.4-1.5
Intermittent access intake escalation 20.10.10.20.0-0.2-0.0-0.0-0.1-0.2-0.3-0.40.3-0.2-0.30.30.3-0.5
Intermitt. access day 1 inactive lever presses0.10.10.20.3-0.1-0.3-0.40.30.40.10.0-0.40.20.4-0.4-0.30.2
Intermitt. access day 15 inactive lever presses0.40.42.00.4-1.4-0.6-0.30.3-0.3-0.6-0.70.4-0.6-0.50.50.5-0.6
Intermitt. access escalation Index0.10.10.60.3-0.3-0.3-0.20.30.30.60.8-0.30.10.2-0.2-0.30.3
Intermittent access day 1 total infusions1.92.35.12.0-2.3-2.1-1.91.91.40.90.8-1.21.21.2-1.2-1.20.7
Intermittent access day 15 total infusions0.60.71.60.2-1.0-0.3-0.1-0.1-0.6-1.2-1.30.8-0.8-0.80.80.9-1.3
Intermittent access terminal intake (last 3 days)0.50.62.81.1-1.7-1.1-1.00.80.2-0.5-0.70.1-0.0-0.10.10.1-0.7
Intermittent access total infusions0.50.62.81.0-1.7-1.1-1.00.70.2-0.6-0.70.1-0.1-0.20.20.2-0.7
Intermittent access day 1 locomotion0.30.30.80.9-0.8-0.8-0.90.70.60.00.1-0.40.50.4-0.4-0.40.0
Intermittent access day 15 total locomotion2.83.06.1-1.31.21.51.3-1.6-1.5-2.5-2.51.7-1.5-1.71.71.7-2.1
Intermittent access total locomotion1.21.43.3-0.3-0.00.50.3-0.7-1.0-1.8-1.81.2-1.1-1.31.31.3-1.7
Intermittent access standard deviation0.20.20.5-0.50.20.40.5-0.4-0.5-0.6-0.70.4-0.4-0.30.30.5-0.5
Left kidney weight0.10.21.0-0.31.00.40.2-0.10.30.30.2-0.50.20.5-0.5-0.30.6
Right kidney weight0.30.91.7-1.11.31.21.0-1.1-0.8-1.1-1.00.8-1.0-0.70.70.9-0.6
Cocaine induced anxiety0.10.10.30.4-0.6-0.3-0.30.2-0.0-0.2-0.20.2-0.3-0.10.10.3-0.5
Post-drug Anxiety0.40.42.20.9-1.5-1.0-0.80.70.20.10.1-0.0-0.2-0.10.10.1-0.4
Baseline Anxiety0.20.20.4-0.60.30.50.6-0.5-0.5-0.3-0.40.5-0.4-0.40.40.4-0.1
Tail length0.00.10.50.0-0.0-0.1-0.00.20.20.70.6-0.30.60.3-0.3-0.40.6
Length with tail0.41.52.61.1-0.8-1.1-1.11.21.21.51.6-1.21.01.3-1.3-1.21.3
Length without tail2.04.56.32.0-0.8-1.8-2.12.02.42.12.4-2.41.72.5-2.5-2.22.1
Times rat made contact with spout0.70.82.11.1-1.4-1.2-1.01.00.70.70.7-0.60.80.6-0.6-0.60.7
Lifetime Intake0.70.83.61.4-1.9-1.4-1.31.10.5-0.1-0.2-0.30.20.3-0.3-0.2-0.2
Liver weight, left0.40.63.71.1-1.9-1.3-1.00.90.2-0.1-0.1-0.0-0.30.1-0.10.00.1
Liver weight, right0.00.10.20.3-0.5-0.4-0.30.30.2-0.0-0.3-0.1-0.10.1-0.1-0.00.1
Locomotor activity3.55.67.12.4-1.2-2.1-2.52.42.72.42.3-2.62.52.6-2.6-2.41.9
Locomotor testing distance1.11.82.91.5-0.4-1.1-1.61.31.61.01.0-1.51.71.5-1.5-1.40.7
Locomotor testing rearing0.40.61.80.60.4-0.4-0.80.61.00.50.6-0.91.30.8-0.8-1.00.5
Locomotion in novel chamber0.30.40.90.1-0.7-0.1-0.0-0.2-0.5-0.8-0.80.8-0.1-0.90.90.6-0.9
Locomotion in novel chamber post-restriction0.10.10.3-0.10.50.20.10.00.20.40.4-0.3-0.00.3-0.3-0.20.3
Fecal boli incidents, locomotor time 11.31.42.41.3-1.6-1.4-1.21.31.01.01.0-1.01.21.0-1.0-1.11.0
Change in fecal boli incidents, locomotor task0.90.91.2-0.90.81.00.9-1.0-1.0-1.1-1.11.0-0.5-0.90.90.9-0.9
Time >=10cm from walls, locomotor time 10.20.20.40.3-0.2-0.4-0.30.40.50.60.5-0.50.30.7-0.7-0.50.6
Bouts of movement, locomotor time 10.80.91.50.60.2-0.5-0.70.81.21.01.1-1.21.11.1-1.1-1.10.9
Total resting periods, locomotor time 10.70.81.30.7-0.3-0.7-0.70.81.01.11.0-1.11.21.0-1.0-1.00.9
Rest time, locomotor task time 10.70.71.41.0-1.2-1.1-1.01.00.70.50.6-0.61.10.6-0.6-0.80.5
Distance moved, locomotor task time 11.31.43.7-1.21.21.21.2-1.2-1.1-0.9-1.00.9-1.9-0.90.91.4-1.1
Vertical activity count, locomotor time 11.11.23.1-1.11.01.11.2-1.1-1.0-0.8-0.90.9-1.8-0.80.81.3-0.9
Time >=10cm from walls, locomotor time 20.20.20.60.5-0.8-0.6-0.50.50.30.40.3-0.30.80.3-0.3-0.40.4
Bouts of movement, locomotor time 20.00.00.1-0.1-0.0-0.00.10.10.10.30.2-0.20.30.1-0.1-0.20.3
Total resting periods, locomotor time 20.00.10.10.0-0.2-0.2-0.00.20.20.30.3-0.20.30.1-0.1-0.30.3
Rest time, locomotor task time 20.00.00.4-0.10.20.10.1-0.10.0-0.1-0.00.00.6-0.00.0-0.30.1
Distance moved, locomotor task time 20.20.21.40.0-0.10.00.0-0.1-0.2-0.3-0.30.2-1.2-0.30.30.7-0.6
Vertical activity count, locomotor time 20.20.21.00.5-1.0-0.5-0.40.3-0.2-0.3-0.30.2-0.6-0.30.30.4-0.5
Light reinforcement 11.22.13.51.2-0.2-1.0-1.31.31.71.41.1-1.91.81.8-1.8-1.71.4
Light reinforcement 20.00.10.20.3-0.2-0.3-0.30.30.30.3-0.1-0.40.10.1-0.1-0.10.2
Bone: marrow area0.61.42.31.00.4-0.6-1.10.91.41.51.4-1.40.81.4-1.4-1.11.1
Bone: maximum diameter0.30.51.00.30.8-0.0-0.30.30.80.81.0-0.81.00.8-0.8-0.80.8
Bone: maximum force1.62.74.41.20.3-0.9-1.31.31.91.91.8-2.02.12.0-2.0-1.71.6
Bone: maximum moment1.62.84.91.10.5-0.8-1.31.21.91.91.8-2.02.22.0-2.0-1.81.7
Mean time between licks in bursts2.53.55.61.6-1.0-1.6-1.61.81.91.81.9-2.11.82.1-2.1-2.02.4
Mean num. licks in bursts3.13.74.71.9-1.5-1.9-1.92.02.01.91.8-2.01.82.0-2.0-1.92.2
Cd content in liver0.50.61.61.1-1.3-1.1-1.00.90.60.50.3-0.40.70.4-0.4-0.40.6
Co content in liver0.10.20.80.4-0.9-0.4-0.30.2-0.2-0.4-0.50.4-0.1-0.40.40.4-0.4
Cu content in liver0.40.40.90.7-0.9-0.8-0.70.80.60.70.7-0.60.20.6-0.6-0.50.6
Fe content in liver0.30.41.30.8-1.1-0.9-0.70.80.50.40.4-0.50.20.5-0.5-0.50.3
K content in liver0.30.31.7-0.61.30.70.6-0.40.10.50.3-0.40.20.3-0.3-0.30.5
Mg content in liver0.90.92.00.00.8-0.0-0.10.40.91.11.0-1.21.11.2-1.2-1.11.4
Mn content in liver0.40.41.20.00.5-0.0-0.10.30.60.70.4-0.81.10.8-0.8-0.90.6
Na content in liver1.71.82.2-1.41.41.51.4-1.5-1.3-1.3-1.31.2-1.5-1.31.31.3-1.2
Rb content in liver0.10.10.4-0.50.60.50.4-0.4-0.2-0.5-0.30.30.0-0.20.20.0-0.1
Se content in liver0.30.41.50.9-1.2-0.9-0.90.80.40.60.3-0.30.30.2-0.2-0.2-0.1
Sr content in liver1.91.82.8-0.8-0.00.70.8-1.0-1.4-1.4-1.61.7-1.3-1.71.71.6-1.7
Zn content in liver0.30.30.90.2-0.3-0.4-0.10.40.40.70.7-0.60.00.6-0.6-0.61.0
Bone: minimum diameter2.75.17.71.70.2-1.4-1.91.92.62.52.4-2.82.62.7-2.7-2.62.3
Time in familiar zone, hab. session 10.20.20.70.1-0.8-0.3-0.10.0-0.4-0.2-0.20.5-0.5-0.50.50.5-0.3
Time in novel zone, hab. session 11.21.24.0-1.42.01.61.3-1.3-0.8-0.9-0.90.7-0.5-0.70.70.5-0.8
Total zone transitions, hab. session 10.50.71.6-0.91.31.10.8-0.9-0.6-0.9-1.00.6-0.9-0.60.60.8-0.9
Total locomotion distance, hab. session 11.82.66.6-1.92.62.11.8-1.8-1.2-1.3-1.41.1-1.5-1.21.21.3-1.4
Locomotion velocity, hab. session 11.52.25.7-1.72.42.01.6-1.7-1.1-1.2-1.31.0-1.3-1.01.01.1-1.2
Time in familiar zone, hab. session 20.20.20.40.4-0.3-0.4-0.40.50.40.40.6-0.50.50.5-0.5-0.40.4
Time in novel zone, hab. session 21.11.11.9-1.21.41.31.1-1.2-0.9-1.1-1.11.0-0.7-1.01.00.7-0.7
Total zone transitions, hab. session 20.10.20.6-0.10.10.20.1-0.2-0.2-0.8-0.70.3-0.6-0.30.30.4-0.7
Total locomotion distance, hab. session 20.20.30.5-0.40.50.60.4-0.5-0.4-0.6-0.70.5-0.7-0.50.50.5-0.7
Locomotion velocity, hab. session 20.10.20.4-0.30.40.40.3-0.4-0.3-0.5-0.60.4-0.6-0.40.40.4-0.6
Novel to familiar place preference ratio5.05.28.0-2.82.62.82.8-2.6-2.2-2.3-2.12.0-1.6-2.02.01.9-1.4
Novelty place preference6.46.510.2-3.23.03.13.2-2.9-2.5-2.5-2.32.3-1.9-2.32.32.1-1.6
Time in novel zone, NPP test6.97.111.1-3.33.23.33.3-3.1-2.6-2.7-2.42.3-1.9-2.32.32.2-1.6
Total zone transitions, NPP test0.20.30.90.9-0.9-0.8-0.90.60.4-0.1-0.2-0.3-0.30.3-0.3-0.1-0.6
Total locomotion distance, NPP test0.10.10.30.5-0.4-0.4-0.40.30.2-0.2-0.1-0.1-0.50.1-0.10.1-0.5
Locomotion velocity, NPP test0.20.20.60.8-0.6-0.6-0.80.60.50.10.2-0.4-0.20.4-0.4-0.2-0.3
Intraocular pressure0.71.01.51.2-1.0-1.2-1.21.21.10.60.7-1.00.80.9-0.9-1.10.7
Delta distance traveled before/after self-admin0.30.31.50.8-1.2-0.9-0.80.70.30.1-0.0-0.10.10.1-0.1-0.1-0.0
Delta ambulatory time before/after self-admin0.10.10.80.5-0.9-0.6-0.50.40.1-0.1-0.10.1-0.0-0.10.10.1-0.3
Parametrial fat weight0.00.00.10.20.3-0.1-0.30.10.30.10.3-0.20.00.2-0.2-0.00.3
Pavlov. Cond. lever latency0.60.82.1-1.31.41.31.2-1.1-0.8-0.7-0.50.8-0.4-0.70.70.5-0.2
Pavlov. Cond. magazine entry latency0.00.00.1-0.10.10.10.1-0.1-0.1-0.0-0.10.0-0.4-0.10.10.3-0.1
Pavlov. Cond. change in total contacts0.10.10.80.5-0.9-0.5-0.40.40.00.1-0.2-0.0-0.5-0.00.00.3-0.4
Pavlov. Cond. index score0.20.20.60.4-0.8-0.4-0.30.2-0.2-0.3-0.40.2-0.8-0.30.30.6-0.7
Pavlov. Cond. latency score0.20.31.20.8-1.1-0.8-0.70.60.30.20.0-0.3-0.30.2-0.20.1-0.2
Pavlov. Cond. lever contacts0.70.81.51.2-1.1-1.2-1.21.10.90.70.6-0.80.30.8-0.8-0.50.2
Pavlov. Cond. magazine entry number0.91.12.60.6-0.0-0.6-0.70.81.11.21.2-1.01.61.1-1.1-1.41.2
Pavlov. Cond. intertrial magazine entries0.40.50.70.6-0.5-0.7-0.60.70.70.40.6-0.70.90.8-0.8-0.80.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.90.2-0.6-0.2-0.10.0-0.3-0.4-0.50.3-0.9-0.30.30.7-0.7
Pavlov. Cond. response bias0.60.71.7-0.40.00.40.4-0.6-0.8-0.9-1.00.8-1.3-0.80.81.1-1.1
Pavlov. Cond. lever latency0.30.40.70.5-0.5-0.6-0.50.60.60.70.6-0.60.50.7-0.7-0.70.9
Pavlov. Cond. magazine entry latency0.30.30.6-0.4-0.30.20.5-0.4-0.7-0.7-0.80.7-0.3-0.80.80.7-0.4
Pavlov. Cond. change in total contacts0.10.20.60.7-0.8-0.6-0.60.50.3-0.10.1-0.10.20.1-0.1-0.1-0.3
Pavlov. Cond. index score0.40.50.7-0.40.10.40.5-0.6-0.7-0.8-0.80.8-0.7-0.80.80.9-0.9
Pavlov. Cond. latency score0.30.40.7-0.3-0.10.30.4-0.5-0.7-0.7-0.70.7-0.6-0.80.80.8-0.8
Pavlov. Cond. lever contacts0.60.81.0-0.90.80.90.9-0.9-0.9-1.0-0.80.8-0.8-0.80.80.9-1.0
Pavlov. Cond. magazine entry number0.91.01.60.8-0.3-0.8-0.80.91.11.31.3-1.10.91.2-1.2-1.21.0
Pavlov. Cond. intertrial magazine entries0.40.51.00.50.5-0.2-0.60.40.81.01.0-0.80.50.8-0.8-0.70.4
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.4-0.10.30.4-0.5-0.7-0.9-0.80.8-0.7-0.80.80.9-0.9
Pavlov. Cond. response bias0.50.71.1-0.80.60.80.8-0.8-0.8-1.1-0.90.8-0.7-0.80.80.9-0.9
Time in closed arm before self-admin0.20.20.4-0.40.20.30.4-0.4-0.4-0.4-0.60.4-0.3-0.50.50.4-0.4
Time in closed arm after self-admin0.10.10.30.00.40.0-0.10.10.40.60.5-0.50.30.4-0.4-0.40.5
Time in open arm before self-admin0.50.61.3-0.91.21.00.9-0.9-0.7-0.7-0.70.5-0.7-0.50.50.6-0.5
Time in open arm after self-admin0.10.10.2-0.2-0.30.10.2-0.2-0.4-0.3-0.40.4-0.3-0.40.40.4-0.3
Bone: periosteal estimation1.22.53.91.10.8-0.7-1.21.11.91.91.9-2.01.71.9-1.9-1.71.6
Bone: periosteal perimeter0.91.52.30.90.2-0.6-0.91.01.41.41.5-1.51.51.4-1.4-1.41.2
Bone: post-yield work0.71.03.91.3-2.0-1.5-1.21.20.60.90.4-0.50.80.5-0.5-0.40.5
Progressive ratio test 1 active lever presses0.60.61.41.2-0.9-1.1-1.21.00.90.10.3-0.70.70.6-0.6-0.70.2
Progressive ratio test 1 breakpoint0.70.71.61.2-0.9-1.1-1.31.00.90.10.2-0.70.70.7-0.7-0.70.2
Progressive ratio test 1 inactive lever presses0.20.31.00.8-1.0-0.8-0.80.60.3-0.3-0.2-0.20.20.2-0.2-0.1-0.3
Progressive ratio test 2 active lever presses0.50.51.20.4-1.0-0.4-0.30.1-0.4-1.0-1.00.6-0.7-0.70.70.7-1.1
Progressive ratio test 2 breakpoint0.81.02.20.0-0.8-0.10.0-0.3-0.8-1.4-1.41.1-1.1-1.11.11.1-1.5
Progressive ratio test 2 inactive lever presses0.40.51.50.4-1.2-0.5-0.30.1-0.4-0.9-0.90.6-0.7-0.60.60.7-0.9
Incentive Sensitization - Responses1.31.32.6-0.5-0.10.50.5-0.8-1.1-1.6-1.61.3-1.3-1.31.31.3-1.5
Incentive Sensitization - Breakpoint1.31.32.6-0.4-0.40.40.4-0.7-1.1-1.6-1.61.3-1.4-1.41.41.4-1.5
Sum of active levers in priming session hrs 5-61.01.02.21.4-1.5-1.4-1.41.20.90.60.6-0.71.00.7-0.7-0.80.5
Progressive ratio0.20.20.30.5-0.2-0.4-0.50.40.50.20.3-0.50.60.6-0.6-0.50.3
Food seeking constrained by brief footshock0.10.10.3-0.10.60.10.10.00.30.20.4-0.40.30.5-0.5-0.40.3
Seeking ratio, punishment vs. effort0.30.40.7-0.80.60.70.8-0.7-0.7-0.4-0.40.6-0.8-0.60.60.6-0.4
Retroperitoneal fat weight0.31.01.51.00.0-0.7-1.10.81.20.91.1-1.21.01.2-1.2-0.90.9
Reaction time number correct0.81.15.31.6-2.3-1.7-1.51.30.60.10.0-0.20.20.2-0.2-0.3-0.2
Reaction time mean minus median0.10.10.70.1-0.9-0.4-0.00.2-0.1-0.0-0.00.00.3-0.20.2-0.00.3
Reaction time mean minus median AUC0.30.40.8-0.5-0.30.30.6-0.5-0.8-0.9-0.80.7-0.3-0.80.80.6-0.3
Reaction time num false alarms0.00.10.3-0.10.20.20.1-0.2-0.1-0.6-0.30.10.0-0.20.20.0-0.4
Reaction time num false alarms AUC0.10.10.4-0.10.00.10.1-0.1-0.2-0.6-0.40.2-0.1-0.20.20.1-0.5
Reaction time trials correct on left0.81.15.31.6-2.3-1.7-1.51.30.60.10.0-0.20.20.2-0.2-0.3-0.2
Reaction time trials on left0.81.25.61.7-2.4-1.7-1.61.30.60.20.1-0.30.30.3-0.3-0.4-0.1
Reaction time mean1.31.84.21.5-2.0-1.7-1.41.61.10.91.3-1.11.30.9-0.9-1.11.1
Reaction time mean AUC1.11.43.61.3-1.9-1.5-1.31.40.90.91.1-1.01.20.8-0.8-1.01.0
Median of all reaction times1.01.43.81.4-1.9-1.6-1.31.41.00.81.1-0.91.10.8-0.8-1.00.8
Reaction time omissions2.12.84.51.3-1.0-1.4-1.21.61.72.12.0-1.81.51.8-1.8-1.82.1
Reaction time false alarm rate0.40.61.6-1.01.31.11.0-0.9-0.6-0.8-0.50.4-0.3-0.40.40.4-0.5
Reaction time premature initiation rate0.30.40.9-1.00.80.91.0-0.8-0.70.1-0.40.5-0.4-0.50.50.6-0.1
Reaction time premature initiations0.10.10.40.1-0.6-0.2-0.00.1-0.20.2-0.30.3-0.2-0.30.30.3-0.2
Std. dev. reaction times0.10.21.10.4-1.0-0.6-0.30.50.10.20.3-0.20.50.1-0.1-0.30.5
Reaction time trials completed0.81.25.61.7-2.4-1.7-1.61.30.60.20.1-0.30.30.3-0.3-0.4-0.1
Reaction time trials AUC0.81.25.11.7-2.3-1.7-1.61.40.70.30.3-0.40.40.4-0.4-0.5-0.0
Run reversals in cocaine runway, females0.90.81.3-0.70.20.70.7-0.8-1.0-1.2-1.11.1-1.2-0.90.91.0-1.0
Run reversals in cocaine runway, males0.10.10.20.5-0.2-0.3-0.50.30.3-0.00.2-0.2-0.10.1-0.1-0.1-0.1
Latency to leave start box in cocaine runway0.10.20.30.4-0.5-0.4-0.30.40.30.50.4-0.40.30.3-0.3-0.30.4
Latency to leave start box in cocaine runway, F0.20.20.50.4-0.5-0.5-0.40.60.50.70.6-0.50.30.4-0.4-0.40.4
Latency to leave start box in cocaine runway, M0.00.00.1-0.0-0.1-0.00.00.00.00.20.1-0.00.30.1-0.1-0.10.4
Std. dev. time between licks in bursts1.21.42.10.9-0.4-0.9-1.01.11.31.51.3-1.41.31.4-1.4-1.31.4
Total sessions with >9 infusions2.02.22.71.6-1.2-1.6-1.61.61.61.31.1-1.61.41.6-1.6-1.51.2
Short access day 1 total inactive lever presses1.92.13.2-1.21.21.41.2-1.5-1.3-1.8-1.61.4-1.7-1.41.41.6-1.5
Short access day 10 total inactive lever presses1.41.61.9-1.41.21.41.4-1.4-1.3-1.1-1.11.2-1.2-1.31.31.3-1.1
Short access day 1 total infusions0.30.30.70.8-0.6-0.7-0.80.60.60.40.5-0.50.30.5-0.5-0.40.3
Short access day 10 total infusions0.70.81.91.3-1.4-1.3-1.21.10.80.20.1-0.70.60.6-0.6-0.60.1
Short access total infusions1.21.42.71.6-1.7-1.6-1.61.51.20.80.7-1.00.81.0-1.0-0.90.6
Short access day 1 locomotion1.11.11.6-0.90.81.00.8-1.1-1.0-1.3-1.21.1-1.1-1.11.11.1-1.2
Short access day 10 total locomotion0.70.81.3-0.90.80.90.8-0.9-0.8-1.1-1.10.8-0.9-0.90.90.9-1.0
Short access total locomotion0.10.10.30.5-0.6-0.5-0.50.40.3-0.2-0.3-0.10.00.1-0.1-0.0-0.3
One hour access (0.3 mA shock)0.30.31.40.5-1.2-0.6-0.50.3-0.2-0.7-0.90.3-0.4-0.40.40.5-0.8
Compulsive drug intake0.50.51.10.6-0.1-0.5-0.70.60.80.81.0-0.70.70.7-0.7-0.80.7
One hour access (shock baseline)0.40.52.70.7-1.7-0.9-0.60.5-0.1-0.5-0.80.3-0.2-0.30.30.4-0.7
Social response proportion2.83.03.71.8-1.8-1.9-1.81.91.71.81.7-1.51.61.6-1.6-1.71.8
Social responses0.10.20.3-0.40.40.40.4-0.5-0.4-0.5-0.50.5-0.3-0.40.40.4-0.3
Social time4.45.87.32.5-2.4-2.7-2.42.72.41.92.1-2.42.52.3-2.3-2.62.4
Soleus weight5.215.335.6-5.16.05.35.0-4.8-3.5-3.0-2.92.8-2.9-2.92.92.9-2.3
Bone: stiffness0.61.01.80.70.1-0.6-0.80.81.10.91.1-1.21.41.2-1.2-1.01.0
Tibialis anterior weight0.51.73.7-1.21.91.61.1-1.5-1.0-1.0-1.31.1-1.2-1.01.01.2-1.6
Time to tail flick, vehicle, before self-admin1.81.82.51.3-1.2-1.4-1.21.41.31.51.1-1.41.61.4-1.4-1.41.4
Time to tail flick, vehicle, after self-admin0.91.04.51.2-2.1-1.5-1.11.20.50.60.5-0.50.80.5-0.5-0.60.3
Time to tail flick, test, before self-admin0.50.51.4-1.11.21.11.1-0.9-0.6-0.1-0.30.4-0.4-0.40.40.40.2
Time to tail flick, test, after self-admin1.91.93.2-1.81.41.61.8-1.6-1.5-1.1-1.11.2-1.1-1.31.31.2-1.2
Delta time to tail flick, vehicle, before/after SA0.30.32.10.7-1.4-0.9-0.70.70.20.20.2-0.20.30.1-0.1-0.20.0
Delta time to tail flick, test, before/after SA1.91.72.6-1.30.71.21.3-1.3-1.4-1.4-1.31.4-1.2-1.41.41.4-1.6
Tibia length4.011.313.43.6-2.6-3.5-3.63.63.53.43.7-3.42.93.4-3.4-3.13.1
Ambulatory time before self-admin0.80.82.0-1.11.41.21.1-1.1-0.7-0.8-1.00.6-0.6-0.60.60.6-0.4
Ambulatory time after self-admin0.50.51.2-0.70.60.70.7-0.8-0.7-0.9-1.10.8-0.4-0.70.70.7-0.6
Bone: tissue strength4.74.67.31.20.5-1.0-1.41.62.42.32.4-2.62.72.5-2.5-2.72.6
Total heroin consumption5.15.97.7-2.72.72.82.6-2.7-2.3-2.5-2.72.2-2.1-2.12.12.2-2.1
Bone: trabecular number6.610.412.6-3.53.13.53.5-3.5-3.2-3.1-3.23.1-2.9-3.23.22.9-2.9
Bone: trabecular spacing5.16.67.52.6-2.1-2.7-2.62.72.72.42.6-2.62.72.5-2.5-2.52.6
Bone: trabecular thickness0.10.20.4-0.60.60.50.6-0.5-0.4-0.3-0.30.30.0-0.20.20.10.2
Bone: trabecular tissue density1.11.62.01.1-1.4-1.4-1.11.41.21.21.2-1.31.11.3-1.3-1.11.4
Water consumed over 24 hours0.10.10.20.10.40.0-0.10.00.30.30.5-0.20.40.2-0.2-0.20.3
Number of responses in last shaping day1.61.72.2-1.00.61.01.1-1.2-1.4-1.5-1.41.5-1.5-1.51.51.5-1.4