Hub : Genes

Ndufaf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Ndufaf1 0.53 0.13 2.0e-07 0.03 0.1 0.09 0.09 2.7e-03 4.3e-08 1.0e-07 2.5e-07
2 pVTA isoform ratio NM_001106500.1 0.04 0.03 8.3e-04 0.05 0.04 0.04 0.05 3.4e-05 6.0e-04 2.4e-04 6.9e-05
3 NAcc gene expression Ndufaf1 0.24 0.1 1.3e-06 0.04 0.05 0.04 0.04 7.3e-07 3.8e-08 2.0e-07 5.7e-07
4 Brain alternative TSS XM_006234740.5 0.11 0.05 1.9e-13 0.11 0.14 0.12 0.14 1.7e-10 2.6e-13 5.9e-11 1.1e-12
5 Brain alternative TSS XM_006234737.4 0.16 0.07 0.0e+00 0.19 0.22 0.22 0.22 1.2e-17 1.0e-20 9.3e-20 1.3e-20
6 Brain isoform ratio XM_006234737.4 0.05 0.03 2.0e-05 0.04 0.05 0.04 0.05 5.1e-05 1.7e-05 4.9e-05 4.2e-05
7 Brain gene expression Ndufaf1 0.09 0.05 2.1e-07 0.05 0.08 0.08 0.08 2.4e-05 9.5e-08 7.7e-08 1.2e-07
8 Brain alternative TSS XM_006234738.5 0.18 0.08 0.0e+00 0.22 0.24 0.24 0.24 1.2e-20 1.5e-22 7.0e-22 6.6e-22
9 Brain alternative TSS XM_006234737.4 0.18 0.08 0.0e+00 0.2 0.24 0.24 0.24 1.9e-18 1.1e-22 4.3e-22 4.2e-22
10 BLA gene expression Ndufaf1 0.39 0.16 1.7e-06 0.1 0.1 0.11 -0 6.5e-06 6.6e-06 1.4e-06 8.4e-01
11 NAcc isoform ratio NM_001106500.1 0.02 0.01 9.3e-03 0 0.01 0 0 3.8e-01 2.4e-02 2.2e-01 3.0e-01
12 Brain isoform ratio NM_001106500.1 0.03 0.02 5.2e-03 0.02 0.01 0.01 0.02 3.1e-03 1.3e-02 5.4e-02 8.4e-03
13 Adipose gene expression Ndufaf1 0.04 0.03 2.7e-03 0 0.01 -0 0 9.7e-02 4.2e-02 7.1e-01 2.4e-01
14 BLA alternative TSS XM_006234740.5 0.08 0.05 7.5e-03 0.02 0.02 0.02 0 4.5e-02 2.6e-02 4.3e-02 3.4e-01
15 PL gene expression Ndufaf1 0.34 0.15 1.7e-08 0.02 0.07 0.09 0.06 3.2e-03 4.9e-08 3.2e-10 1.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.81.42.21.4-1.51.31.3-1.3-1.31.31.3-1.31.0-0.71.30.9-0.71.1
Area under the delay curve1.61.93.51.7-0.61.61.4-1.6-1.91.21.7-1.7-0.21.31.2-1.11.7-0.0
BMI with tail4.314.920.54.2-4.24.44.5-4.5-4.54.44.5-4.53.5-2.53.42.8-1.23.0
BMI without tail5.717.424.03.7-4.74.14.9-4.8-4.94.94.8-4.83.4-3.14.43.6-2.43.0
Body weight4.821.030.04.4-5.54.75.5-5.5-5.34.95.4-5.44.2-3.43.83.7-1.73.5
Weight adjusted by age0.61.02.00.6-1.30.81.4-1.4-1.30.91.4-1.40.4-0.70.50.60.2-0.4
Bone surface1.32.34.22.0-2.11.91.2-1.2-1.11.51.2-1.21.8-1.50.91.6-1.41.6
Bone volume1.52.86.22.5-1.82.31.4-1.4-1.31.81.3-1.41.9-1.51.11.6-1.31.6
Breakpoint value in progressive ratio session0.20.31.31.10.70.6-0.60.60.50.1-0.60.60.40.00.00.1-0.60.4
Number of licking bursts0.20.31.21.10.60.5-0.60.60.40.2-0.60.60.40.20.10.0-0.60.5
Context. condit. distance diff. score2.42.95.21.2-1.81.21.6-1.5-1.51.91.4-1.41.6-2.12.12.3-2.21.2
Locomotion velocity, session 14.44.76.6-2.42.2-2.4-2.01.91.7-2.3-1.81.8-2.52.5-1.4-2.62.0-2.4
Locomotion distance, session 12.53.16.0-2.41.4-2.4-1.41.41.2-2.0-1.31.4-2.41.9-0.9-1.91.4-2.1
Locomotion velocity, session 20.70.91.80.1-0.20.10.8-0.9-1.30.41.0-1.0-0.91.31.3-1.11.2-1.0
Locomotion distance, session 20.91.23.2-1.70.6-1.8-0.90.90.7-1.2-0.90.9-1.61.1-0.1-1.00.4-1.3
Locomotion velocity, session 30.40.51.71.30.50.90.1-0.2-0.50.40.3-0.3-0.11.20.5-1.01.0-0.5
Locomotion distance, session 30.50.63.01.70.41.2-0.00.0-0.31.1-0.00.00.8-0.11.00.5-1.00.1
Stereotopy head waving bouts, day 32.32.75.21.6-1.91.82.2-2.2-2.21.72.3-2.31.1-0.51.10.50.70.4
Stereotopy head waving duration, day 32.32.75.71.5-1.61.72.2-2.3-2.41.52.4-2.40.60.31.3-0.21.30.3
Locomotion velocity, session 70.40.41.10.4-0.50.40.6-0.6-0.81.00.6-0.60.2-0.41.10.6-0.7-0.5
Locomotion distance, session 70.30.42.4-0.5-0.3-0.4-0.00.20.10.4-0.30.30.1-1.00.71.1-1.6-0.2
Stereotopy head waving bouts, day 70.10.10.60.50.30.5-0.10.10.2-0.1-0.10.00.20.3-0.8-0.40.70.2
Stereotopy head waving duration, day 70.20.31.01.00.11.00.1-0.20.00.20.2-0.20.7-0.0-0.8-0.10.70.5
Locomotion velocity, session 81.51.84.40.7-1.10.81.8-1.8-2.11.41.9-1.90.20.12.00.20.2-0.3
Locomotion distance, session 80.60.82.9-0.3-1.2-0.30.8-0.7-0.90.80.7-0.60.1-0.91.71.2-1.5-0.1
Degree of sensitization distance0.60.62.5-1.6-0.2-1.1-0.40.50.8-0.8-0.60.6-0.2-0.9-1.10.6-0.50.2
Degree of sensitization stereotypy0.20.21.20.20.30.2-0.50.50.7-0.2-0.50.50.5-0.5-1.10.3-0.10.4
Conditioned locomotion1.61.82.71.0-1.51.31.5-1.5-1.61.61.5-1.51.0-1.11.71.3-1.01.1
Cocaine response after cond. corrected0.80.93.11.11.80.4-1.31.20.8-0.2-1.11.1-0.51.50.1-1.10.1-0.2
Cocaine response after cond. not corrected1.31.54.20.42.0-0.3-1.51.41.0-0.7-1.31.3-1.22.0-0.0-1.70.6-0.7
Cocaine response before conditioning0.91.14.0-2.00.2-1.6-0.30.30.2-1.1-0.20.3-1.50.9-0.4-1.01.1-1.4
Saline control response1.52.04.60.5-2.10.91.9-1.9-1.51.01.8-1.81.5-1.60.21.3-0.00.8
Bone: connectivity density0.30.42.20.1-1.50.30.8-0.8-0.60.30.8-0.80.5-0.60.00.50.10.7
Bone: cortical apparent density0.81.12.40.40.70.2-1.31.31.6-0.2-1.41.40.8-0.9-1.20.8-1.21.0
Bone: cortical area1.82.74.22.0-2.02.01.9-1.9-1.81.81.9-1.91.7-1.11.11.2-0.41.2
Bone: cortical porosity1.51.75.0-1.11.4-1.4-0.60.60.1-0.9-0.40.5-2.12.20.8-1.91.2-1.6
Bone: cortical porosity0.70.72.4-0.40.5-0.60.1-0.2-0.6-0.20.3-0.3-1.31.51.1-1.31.0-1.2
Bone: cortical thickness1.01.62.81.3-1.61.31.6-1.6-1.71.31.7-1.70.9-0.41.20.50.10.7
Bone: cortical thickness0.70.84.72.20.31.5-0.10.0-0.00.8-0.00.01.00.00.70.3-0.71.3
Bone: cortical tissue density0.81.02.40.40.80.3-1.31.31.5-0.2-1.41.40.8-0.8-1.10.7-1.11.0
Condit. Reinf. active minus inactive responses0.60.73.5-1.0-0.3-0.6-0.60.71.1-0.7-0.80.70.5-1.1-1.90.6-0.10.2
Condit. Reinf. active-inactive response ratio0.50.61.40.7-1.00.90.6-0.6-0.30.60.5-0.61.2-1.2-0.40.9-0.30.8
Condit. Reinf. active responses1.62.07.6-2.00.0-1.4-1.31.42.0-1.4-1.51.50.2-1.3-2.70.6-0.3-0.2
Condit. Reinf. inactive responses1.72.14.3-2.00.7-1.6-1.61.72.0-1.4-1.81.8-0.3-0.6-2.10.3-0.5-0.7
Incentive salience index mean1.72.17.3-2.30.3-1.7-1.41.41.9-1.8-1.51.5-0.4-0.6-2.7-0.00.4-0.5
Condit. Reinf. lever presses1.92.78.0-2.80.3-2.3-1.41.51.9-2.1-1.51.5-1.1-0.1-2.7-0.50.7-1.0
Condit. Reinf. active minus inactive responses1.11.44.70.2-1.60.60.8-0.7-0.20.60.6-0.61.7-2.2-0.41.9-1.31.7
Condit. Reinf. active-inactive response ratio1.01.13.60.5-1.10.70.6-0.5-0.20.60.4-0.41.6-1.9-0.41.7-1.31.5
Condit. Reinf. active responses1.52.16.40.5-2.00.91.1-1.0-0.50.90.9-0.92.1-2.5-0.52.2-1.32.0
Condit. Reinf. inactive responses0.70.92.20.5-1.50.80.9-0.9-0.40.50.8-0.81.4-1.4-0.71.1-0.11.3
Condit. Reinf. lever presses1.01.43.00.8-1.71.31.2-1.2-0.60.71.1-1.11.7-1.5-1.01.10.21.5
Condit. Reinf. lever reinforcers received1.21.65.60.0-1.90.60.9-0.8-0.20.50.7-0.71.8-2.4-0.92.0-1.01.8
Conditioned reinforcement - actives0.30.50.9-0.80.8-0.8-0.60.60.5-0.8-0.50.5-1.01.0-0.5-0.90.7-0.7
Conditioned reinforcement - inactives0.10.10.70.20.10.20.1-0.1-0.20.50.1-0.10.2-0.30.80.5-0.9-0.2
Conditioned locomotion0.70.93.9-1.10.3-0.8-0.10.0-0.0-0.80.1-0.1-1.11.3-0.8-1.52.0-1.4
Patch foraging indifference point 0 sec1.32.35.20.8-1.81.42.1-2.2-1.91.02.3-2.31.0-0.4-0.30.01.80.4
Patch foraging indifference point AUC1.42.13.5-1.31.9-1.4-1.81.81.8-1.5-1.81.8-1.00.8-1.5-1.00.5-1.0
Delay disc. indifference point, 0s delay0.50.63.80.10.10.30.3-0.4-0.3-0.20.5-0.5-0.41.0-0.7-1.22.0-0.6
Delay disc. indifference point, 16s delay0.91.02.91.60.31.20.3-0.5-0.80.50.6-0.6-0.41.70.5-1.51.7-0.4
Delay disc. indifference point, 2s delay0.70.81.10.4-1.10.71.1-1.0-0.91.01.0-1.00.8-1.00.51.0-0.60.8
Delay disc. indifference point, 24s delay1.51.63.4-1.01.1-1.1-1.11.00.9-1.3-0.90.9-1.71.8-0.8-1.81.7-1.4
Delay disc. indifference point, 4s delay0.70.71.50.5-0.30.40.9-1.0-1.20.41.1-1.1-0.61.00.8-0.81.2-0.3
Delay disc. indifference point, 8s delay3.44.08.83.0-1.22.82.2-2.4-2.72.02.6-2.50.71.01.7-0.71.70.5
Indifference point function ln k2.74.68.12.3-2.32.32.4-2.4-2.62.62.4-2.41.6-1.22.81.6-1.21.2
Indifference point function log k2.74.68.12.3-2.32.32.4-2.4-2.62.62.4-2.41.6-1.22.81.6-1.21.2
Patch foraging total patch changes 0 sec1.22.24.61.1-1.61.52.0-2.1-1.81.02.1-2.11.2-0.5-0.30.11.60.6
Patch foraging total patch changes 12 sec0.20.31.9-0.7-0.0-0.40.1-0.10.2-0.60.1-0.10.2-0.4-1.40.00.8-0.1
Patch foraging total patch changes 18 sec0.30.51.7-1.20.6-0.9-0.60.60.8-0.8-0.70.6-0.40.0-1.3-0.30.4-0.6
Patch foraging total patch changes 24 sec0.50.91.90.6-1.20.91.3-1.3-1.20.81.4-1.40.6-0.10.30.10.80.6
Patch foraging total patch changes 6 sec0.10.21.2-0.40.2-0.10.00.00.2-0.30.0-0.00.1-0.1-1.1-0.20.8-0.4
Patch foraging time to switch 0 sec0.51.04.3-1.60.3-1.2-0.70.71.1-1.4-0.70.7-0.4-0.1-2.1-0.30.8-0.1
Patch foraging water rate 0 sec1.32.76.72.6-1.42.31.2-1.2-1.22.11.1-1.12.0-1.51.41.7-1.61.4
Patch foraging water rate 12 sec0.51.14.01.9-0.21.20.0-0.0-0.21.2-0.00.01.0-0.71.61.1-2.01.1
Patch foraging water rate 18 sec0.81.24.72.2-0.41.50.7-0.8-1.11.30.8-0.80.80.21.90.3-0.60.8
Patch foraging water rate 24 sec2.23.29.23.0-0.92.70.7-0.7-0.62.10.6-0.62.5-1.81.12.1-2.31.9
Patch foraging water rate 6 sec0.71.03.91.30.70.7-1.01.00.90.4-1.11.10.9-0.70.30.9-2.00.8
Seeking ratio, delayed vs. immediate footshock0.70.94.10.2-0.50.10.4-0.3-0.10.60.2-0.20.9-1.80.51.8-2.00.9
Distance traveled before self-admin0.50.61.31.0-0.70.90.8-0.8-0.90.90.8-0.80.7-0.41.10.5-0.40.8
Distance traveled after self-admin0.30.41.01.0-0.20.80.1-0.10.10.50.0-0.00.9-0.80.10.8-0.81.0
Extensor digitorum longus weight0.41.44.12.0-1.21.71.2-1.3-1.41.41.3-1.31.0-0.11.20.4-0.10.5
Bone: elastic displacement0.10.10.80.10.50.00.0-0.1-0.1-0.20.1-0.1-0.10.5-0.3-0.60.9-0.3
Bone: elastic work0.71.02.51.6-0.71.51.0-1.1-0.90.81.1-1.11.4-0.7-0.10.50.30.8
Bone: endosteal estimation0.30.61.81.2-0.50.90.2-0.2-0.20.80.1-0.10.8-0.80.81.0-1.30.7
Bone: endosteal perimeter0.10.20.60.5-0.40.50.1-0.1-0.10.40.1-0.10.5-0.60.20.6-0.80.2
Epididymis fat weight0.31.02.80.5-0.70.51.2-1.3-1.50.81.3-1.3-0.30.51.7-0.20.5-0.3
Delta time in closed arm before/after self-admin0.20.21.3-0.5-0.3-0.40.00.10.00.2-0.20.20.1-0.80.30.8-1.1-0.4
Delta time in open arm before/after self-admin2.52.45.22.0-1.01.71.0-0.9-0.91.70.8-0.81.7-1.71.72.0-2.31.9
Diff in mean of infusions in LGA sessions0.20.30.9-1.00.1-0.7-0.30.40.6-0.7-0.40.4-0.1-0.5-1.00.20.1-0.4
Delay discount exponential model param1.31.42.7-1.30.5-1.2-1.21.31.6-1.0-1.51.50.3-1.3-1.11.0-1.50.1
Extinction: sum of active levers before priming1.11.22.7-0.61.7-0.9-1.01.00.9-1.1-0.90.9-1.11.4-0.7-1.41.1-1.2
Active lever presses in extinction session 60.70.71.6-0.70.9-0.8-0.50.50.3-0.7-0.40.4-1.11.2-0.1-1.20.9-1.2
Bone: final force1.42.23.71.5-1.91.61.3-1.2-1.11.61.1-1.11.9-1.90.71.9-1.51.0
Bone: final moment1.32.03.51.6-1.81.71.2-1.2-1.01.61.1-1.11.9-1.80.61.8-1.41.0
Food consumed during 24 hour testing period0.10.10.50.00.3-0.4-0.40.40.3-0.2-0.50.50.00.20.50.0-0.70.6
Glucose1.72.74.52.0-1.41.71.6-1.5-1.72.11.5-1.41.5-1.42.11.7-1.61.0
Heart weight3.25.010.71.5-3.31.72.8-2.7-2.72.22.6-2.61.6-1.82.32.0-1.31.4
Delay discount hyperbolic model param1.21.32.8-1.30.6-1.2-1.31.41.7-1.0-1.51.50.1-0.9-1.10.7-1.3-0.0
Intermittent access intake day 1-15 change0.81.74.32.1-0.41.70.5-0.5-0.71.70.4-0.41.4-0.81.91.3-2.01.4
Intermittent access intake escalation1.12.25.82.4-0.62.10.7-0.7-0.91.90.7-0.71.6-1.01.91.4-1.91.7
Intermittent access intake escalation 20.80.94.21.70.51.1-0.30.2-0.21.1-0.20.30.40.32.10.4-1.70.8
Intermitt. access day 1 inactive lever presses0.31.13.4-0.9-1.8-0.21.5-1.4-1.30.51.4-1.40.3-0.90.50.70.10.1
Intermitt. access day 15 inactive lever presses0.40.81.70.4-1.10.51.0-0.9-0.80.90.8-0.80.7-1.30.91.3-1.20.2
Intermitt. access escalation Index0.81.13.30.8-1.21.10.6-0.6-0.20.80.5-0.51.8-1.8-0.51.5-0.91.2
Intermittent access day 1 total infusions0.30.41.4-0.40.6-0.4-0.30.20.2-0.6-0.20.2-0.60.8-0.9-0.91.2-1.2
Intermittent access day 15 total infusions0.50.71.91.4-0.51.30.6-0.6-0.71.10.6-0.61.1-0.70.80.9-0.90.6
Intermittent access terminal intake (last 3 days)0.60.83.31.8-0.11.40.4-0.4-0.61.20.4-0.41.0-0.41.20.7-1.20.5
Intermittent access total infusions0.10.20.80.9-0.10.70.3-0.3-0.40.40.3-0.30.4-0.10.20.2-0.20.1
Intermittent access day 1 locomotion0.50.72.8-0.1-0.50.10.9-1.0-1.00.11.1-1.1-0.40.70.1-0.81.7-0.7
Intermittent access day 15 total locomotion0.50.92.61.2-0.61.00.8-0.8-1.01.30.8-0.80.7-0.61.60.9-1.10.5
Intermittent access total locomotion0.10.20.30.3-0.00.30.4-0.4-0.60.30.5-0.5-0.20.40.6-0.30.4-0.3
Intermittent access standard deviation0.30.61.91.2-0.31.00.3-0.3-0.51.00.3-0.30.7-0.51.20.8-1.40.4
Left kidney weight1.98.818.81.0-3.71.44.1-4.0-4.32.94.0-4.01.1-1.53.81.9-0.80.3
Right kidney weight2.712.426.71.3-4.42.04.9-4.9-5.23.54.9-4.91.2-1.54.41.9-0.40.6
Cocaine induced anxiety0.71.02.8-1.7-1.2-1.01.2-1.2-1.2-0.01.2-1.2-0.70.00.8-0.10.8-1.1
Post-drug Anxiety1.21.33.4-1.9-1.7-1.11.4-1.3-1.30.31.2-1.2-0.4-0.91.30.8-0.4-0.7
Baseline Anxiety0.20.31.3-0.1-0.4-0.00.00.00.10.3-0.10.10.4-0.90.20.9-1.10.8
Tail length1.97.411.41.7-3.42.03.1-2.9-3.03.02.8-2.82.1-2.63.23.0-2.51.9
Length with tail1.35.610.11.7-3.22.02.8-2.8-2.62.42.7-2.72.2-2.22.02.3-1.41.7
Length without tail0.72.23.61.9-1.71.81.6-1.6-1.61.51.6-1.61.6-0.91.11.0-0.41.1
Times rat made contact with spout0.20.30.50.7-0.60.40.6-0.7-0.60.00.7-0.70.40.1-0.1-0.10.6-0.1
Lifetime Intake0.10.21.11.10.30.80.1-0.1-0.20.20.2-0.20.30.4-0.1-0.40.4-0.0
Liver weight, left3.65.910.52.2-3.22.52.7-2.7-2.42.42.6-2.62.5-2.31.42.4-1.32.7
Liver weight, right2.34.16.42.5-2.22.52.4-2.4-2.42.22.4-2.51.8-1.01.41.1-0.01.4
Locomotor activity0.50.71.5-1.20.8-1.2-0.60.60.5-1.1-0.50.5-1.11.0-0.4-1.00.9-0.8
Locomotor testing distance0.51.01.5-1.21.1-1.2-0.80.80.7-1.1-0.70.7-1.11.0-0.6-1.11.0-1.2
Locomotor testing rearing1.12.14.2-2.11.3-2.1-1.61.61.7-1.8-1.61.6-1.20.5-1.3-0.70.2-1.2
Locomotion in novel chamber0.30.41.01.0-0.41.00.7-0.7-0.70.60.7-0.70.7-0.40.10.30.1-0.3
Locomotion in novel chamber post-restriction1.42.45.01.7-1.51.71.3-1.3-1.21.71.3-1.31.6-1.41.31.6-1.52.2
Fecal boli incidents, locomotor time 10.60.92.40.21.2-0.1-1.00.80.7-0.7-0.80.8-0.81.6-0.6-1.51.2-0.7
Change in fecal boli incidents, locomotor task2.32.23.30.9-1.81.01.7-1.6-1.61.61.5-1.51.3-1.61.61.7-1.41.3
Time >=10cm from walls, locomotor time 10.20.20.90.40.20.3-0.30.30.30.2-0.30.30.5-0.50.10.5-0.91.0
Bouts of movement, locomotor time 13.74.26.4-1.12.5-1.6-2.42.32.2-2.3-2.22.2-1.92.2-1.8-2.31.5-1.3
Total resting periods, locomotor time 13.74.15.9-1.52.3-1.9-2.42.32.3-2.4-2.32.3-1.81.8-2.0-2.01.3-1.2
Rest time, locomotor task time 10.10.10.5-0.3-0.1-0.3-0.20.20.4-0.5-0.30.30.1-0.3-0.70.2-0.10.7
Distance moved, locomotor task time 10.10.10.40.40.40.3-0.20.20.30.0-0.20.20.20.0-0.6-0.10.3-0.5
Vertical activity count, locomotor time 10.10.30.80.8-0.10.80.3-0.2-0.10.70.2-0.20.9-0.80.20.8-0.80.5
Time >=10cm from walls, locomotor time 25.27.813.51.8-3.72.33.5-3.5-3.22.83.4-3.42.5-2.72.02.7-1.11.9
Bouts of movement, locomotor time 20.40.72.31.5-0.51.40.2-0.3-0.00.60.2-0.31.4-0.8-0.20.8-0.51.4
Total resting periods, locomotor time 20.40.72.31.5-0.41.40.1-0.20.10.60.1-0.11.4-0.8-0.20.8-0.51.5
Rest time, locomotor task time 23.74.86.6-2.32.3-2.5-2.62.62.5-2.5-2.62.6-2.21.6-1.8-1.70.7-1.4
Distance moved, locomotor task time 21.41.63.00.8-1.61.21.7-1.7-1.61.41.7-1.71.0-1.10.61.0-0.10.6
Vertical activity count, locomotor time 23.34.66.31.9-2.42.32.3-2.2-1.92.32.1-2.22.5-2.51.22.4-1.42.1
Light reinforcement 10.51.33.1-0.6-1.5-0.11.3-1.3-0.5-0.31.2-1.21.3-1.7-1.80.91.10.7
Light reinforcement 20.91.33.1-1.41.0-1.5-1.11.21.4-1.6-1.21.2-0.80.1-1.7-0.50.5-0.4
Bone: marrow area0.30.61.61.2-0.60.90.3-0.3-0.30.80.2-0.20.8-0.80.81.0-1.30.7
Bone: maximum diameter1.12.13.31.8-1.81.81.4-1.4-1.21.51.3-1.31.7-1.40.71.4-0.91.4
Bone: maximum force1.73.16.71.5-2.61.72.0-2.0-1.81.81.9-1.91.8-1.81.01.8-1.01.0
Bone: maximum moment1.52.65.41.4-2.31.61.8-1.8-1.71.71.7-1.81.7-1.60.91.6-0.90.9
Mean time between licks in bursts0.51.32.7-1.21.3-1.2-1.11.00.7-1.0-1.01.0-1.61.6-0.1-1.50.7-1.3
Mean num. licks in bursts0.30.41.1-0.5-1.1-0.11.0-1.0-0.80.11.0-1.00.1-0.5-0.10.30.6-0.3
Cd content in liver0.50.51.41.1-0.81.20.7-0.7-0.60.90.7-0.70.8-0.60.50.6-0.30.2
Co content in liver0.40.41.61.30.40.80.2-0.3-0.60.40.4-0.4-0.21.10.7-0.90.8-0.2
Cu content in liver0.30.30.9-0.20.8-0.3-0.80.80.6-0.0-0.80.8-0.20.00.40.2-1.0-0.5
Fe content in liver1.61.95.7-1.00.3-0.8-1.71.72.2-1.2-1.91.80.4-1.0-2.40.6-0.90.6
K content in liver0.30.30.80.8-0.30.60.3-0.4-0.50.70.4-0.40.4-0.20.90.4-0.70.7
Mg content in liver2.22.27.32.7-0.72.30.8-0.9-1.02.00.8-0.81.7-0.81.71.2-1.61.6
Mn content in liver1.51.72.71.0-1.41.21.6-1.6-1.61.41.6-1.61.1-0.91.30.9-0.30.8
Na content in liver0.70.72.1-1.50.4-1.2-1.01.01.0-1.0-1.01.1-0.80.2-0.5-0.2-0.4-0.2
Rb content in liver3.74.37.12.5-2.02.52.4-2.4-2.62.62.4-2.41.4-0.82.71.2-0.70.2
Se content in liver0.20.20.50.70.10.60.3-0.2-0.30.70.2-0.20.7-0.50.30.6-0.60.2
Sr content in liver0.40.40.7-0.90.5-0.8-0.30.30.2-0.7-0.20.2-0.90.8-0.1-0.80.7-0.6
Zn content in liver0.70.82.70.10.6-0.0-1.11.11.2-0.1-1.21.20.4-0.6-0.20.8-1.60.7
Bone: minimum diameter1.01.93.91.3-1.61.31.8-1.8-2.01.31.9-1.90.40.21.4-0.10.80.2
Time in familiar zone, hab. session 11.21.22.2-0.41.5-0.8-1.51.41.4-1.1-1.41.4-0.91.0-0.9-1.00.2-0.0
Time in novel zone, hab. session 12.22.23.31.0-1.61.51.8-1.8-1.71.71.7-1.71.6-1.61.01.5-0.60.5
Total zone transitions, hab. session 11.01.42.7-1.50.8-1.6-1.00.90.9-1.5-0.90.9-1.61.3-0.7-1.41.0-0.7
Total locomotion distance, hab. session 11.11.53.6-1.90.7-1.9-0.80.80.7-1.5-0.70.7-1.81.3-0.7-1.41.2-1.0
Locomotion velocity, hab. session 11.72.45.6-2.40.9-2.3-1.11.01.0-2.0-1.01.0-2.21.6-1.1-1.81.5-1.2
Time in familiar zone, hab. session 20.30.41.71.3-0.11.1-0.0-0.00.10.40.0-0.00.8-0.3-0.30.3-0.21.1
Time in novel zone, hab. session 20.30.30.8-0.4-0.5-0.20.8-0.8-0.90.40.8-0.8-0.1-0.10.80.10.1-0.7
Total zone transitions, hab. session 20.60.72.1-1.10.5-1.3-0.60.60.4-0.9-0.50.5-1.51.20.2-1.10.6-0.7
Total locomotion distance, hab. session 20.20.31.4-1.2-0.1-1.1-0.10.10.1-0.7-0.10.1-0.90.3-0.1-0.40.3-0.3
Locomotion velocity, hab. session 20.40.52.0-1.40.0-1.3-0.30.30.3-0.9-0.30.3-1.00.5-0.5-0.60.5-0.4
Novel to familiar place preference ratio1.11.22.20.5-1.50.91.5-1.4-1.21.01.4-1.41.1-1.30.31.1-0.10.8
Novelty place preference1.01.12.00.4-1.40.81.4-1.4-1.21.01.3-1.41.0-1.20.41.0-0.10.6
Time in novel zone, NPP test1.01.11.90.5-1.30.81.4-1.3-1.11.01.3-1.31.1-1.20.41.1-0.20.7
Total zone transitions, NPP test1.42.04.4-1.41.3-1.8-1.31.30.9-1.3-1.21.2-2.11.90.3-1.60.5-1.5
Total locomotion distance, NPP test1.01.44.3-1.70.5-1.8-0.50.40.0-1.0-0.40.4-2.11.70.8-1.40.7-1.7
Locomotion velocity, NPP test1.21.75.1-1.80.7-1.9-0.50.50.1-1.1-0.40.4-2.31.90.7-1.60.9-1.8
Intraocular pressure1.01.42.80.01.6-0.3-1.21.11.2-1.2-1.01.0-0.61.4-1.7-1.51.6-0.8
Delta distance traveled before/after self-admin0.20.21.0-0.20.3-0.2-0.50.50.6-0.5-0.50.50.0-0.1-1.0-0.10.10.2
Delta ambulatory time before/after self-admin0.50.62.3-1.10.4-0.9-0.70.81.0-1.0-0.80.8-0.4-0.1-1.5-0.20.4-0.2
Parametrial fat weight0.30.73.5-1.9-0.8-1.40.3-0.2-0.1-0.90.2-0.2-0.90.0-0.7-0.30.9-1.0
Pavlov. Cond. lever latency1.21.55.92.4-0.42.10.6-0.6-0.61.60.6-0.61.7-0.80.91.0-1.01.3
Pavlov. Cond. magazine entry latency0.60.84.4-2.1-0.9-1.40.4-0.30.1-0.80.2-0.2-0.3-1.1-1.40.50.4-0.5
Pavlov. Cond. change in total contacts0.50.63.3-1.8-0.4-1.5-0.10.20.2-0.6-0.30.3-0.6-0.7-0.10.6-0.8-0.5
Pavlov. Cond. index score1.11.35.9-2.40.1-2.0-0.50.50.7-1.6-0.60.5-1.30.1-1.5-0.60.9-1.0
Pavlov. Cond. latency score1.11.46.3-2.5-0.0-2.0-0.30.40.6-1.6-0.40.4-1.40.3-1.5-0.71.2-1.0
Pavlov. Cond. lever contacts1.51.87.5-2.70.4-2.4-0.70.70.8-1.8-0.70.7-1.70.6-1.2-0.91.0-1.3
Pavlov. Cond. magazine entry number0.40.52.61.61.01.1-0.60.50.20.5-0.40.40.21.01.0-0.5-0.30.3
Pavlov. Cond. intertrial magazine entries1.01.35.42.30.01.8-0.60.50.60.8-0.60.61.6-0.60.10.9-1.41.4
Pavlov. Cond. lever-magazine prob. diff.1.21.56.3-2.50.4-2.2-0.60.70.8-1.6-0.70.7-1.50.3-1.3-0.70.9-1.1
Pavlov. Cond. response bias0.91.15.6-2.40.0-2.0-0.50.60.8-1.3-0.60.6-0.9-0.5-1.20.10.1-0.9
Pavlov. Cond. lever latency2.63.56.5-1.52.6-1.9-2.12.01.5-1.6-2.02.0-2.42.30.0-2.00.5-1.6
Pavlov. Cond. magazine entry latency1.31.55.60.3-1.80.81.0-0.9-0.30.70.8-0.81.9-2.4-1.01.9-0.91.1
Pavlov. Cond. change in total contacts1.01.76.50.0-1.90.60.9-0.8-0.30.60.7-0.71.8-2.5-0.82.2-1.31.3
Pavlov. Cond. index score2.23.08.91.0-2.41.51.5-1.4-0.81.31.2-1.22.6-3.0-0.62.6-1.31.7
Pavlov. Cond. latency score1.82.47.40.8-2.11.31.3-1.2-0.71.21.1-1.12.3-2.7-0.42.4-1.31.4
Pavlov. Cond. lever contacts2.83.97.41.6-2.72.12.1-2.1-1.51.62.0-2.02.7-2.5-0.32.2-0.51.9
Pavlov. Cond. magazine entry number1.51.96.7-0.42.0-0.8-1.10.90.4-0.9-0.80.8-2.02.60.6-2.21.3-1.3
Pavlov. Cond. intertrial magazine entries0.40.62.00.90.30.40.4-0.5-0.80.30.6-0.6-0.61.41.2-1.11.0-0.4
Pavlov. Cond. lever-magazine prob. diff.2.02.78.20.8-2.31.31.4-1.3-0.71.21.2-1.22.4-2.9-0.62.4-1.21.6
Pavlov. Cond. response bias3.64.810.41.6-2.92.22.2-2.1-1.41.81.9-2.03.2-3.2-0.52.8-1.12.3
Time in closed arm before self-admin1.62.03.7-1.11.5-1.1-1.81.71.9-1.7-1.71.7-0.90.9-1.9-1.10.8-0.5
Time in closed arm after self-admin1.21.22.5-1.50.6-1.2-1.31.31.6-1.2-1.41.4-0.4-0.3-1.6-0.0-0.2-0.8
Time in open arm before self-admin0.60.61.41.2-0.51.00.9-1.0-1.00.71.0-1.00.60.10.3-0.10.70.2
Time in open arm after self-admin3.33.68.93.0-1.22.41.6-1.6-1.82.41.6-1.61.7-1.22.41.7-1.81.7
Bone: periosteal estimation0.81.73.51.9-1.51.71.3-1.3-1.31.41.3-1.31.4-1.01.01.1-0.81.0
Bone: periosteal perimeter0.81.32.21.3-1.31.31.4-1.5-1.51.21.5-1.50.8-0.40.90.5-0.00.5
Bone: post-yield work0.30.41.7-1.3-0.2-1.1-0.30.30.1-0.3-0.30.3-1.10.40.7-0.2-0.5-0.9
Progressive ratio test 1 active lever presses0.10.10.50.20.30.1-0.20.20.3-0.2-0.20.20.10.0-0.7-0.20.3-0.3
Progressive ratio test 1 breakpoint0.10.10.5-0.10.3-0.1-0.30.30.3-0.3-0.30.3-0.10.1-0.7-0.20.3-0.4
Progressive ratio test 1 inactive lever presses0.10.10.6-0.7-0.1-0.5-0.10.20.3-0.4-0.20.2-0.2-0.4-0.40.3-0.2-0.8
Progressive ratio test 2 active lever presses0.20.20.70.8-0.10.7-0.00.00.20.3-0.10.10.7-0.7-0.40.6-0.50.6
Progressive ratio test 2 breakpoint0.30.41.01.0-0.30.90.2-0.20.00.50.1-0.10.9-0.8-0.30.8-0.60.7
Progressive ratio test 2 inactive lever presses0.10.20.40.4-0.40.40.4-0.4-0.40.50.4-0.40.4-0.60.30.6-0.5-0.1
Incentive Sensitization - Responses0.20.21.51.20.10.90.1-0.1-0.10.50.1-0.10.5-0.20.10.2-0.20.7
Incentive Sensitization - Breakpoint0.20.21.41.2-0.00.90.1-0.1-0.10.50.1-0.10.6-0.3-0.00.3-0.30.7
Sum of active levers in priming session hrs 5-60.20.20.80.00.5-0.3-0.50.60.4-0.1-0.60.6-0.10.00.40.2-0.9-0.2
Progressive ratio0.10.10.4-0.40.0-0.3-0.30.30.5-0.3-0.40.40.0-0.3-0.50.2-0.30.6
Food seeking constrained by brief footshock0.10.10.5-0.70.1-0.4-0.10.10.1-0.2-0.10.1-0.50.3-0.1-0.30.3-0.3
Seeking ratio, punishment vs. effort0.00.10.4-0.10.2-0.00.00.0-0.10.00.0-0.0-0.10.30.0-0.30.5-0.6
Retroperitoneal fat weight2.310.019.51.9-4.42.74.1-4.0-3.52.93.9-3.93.1-3.11.42.9-0.62.3
Reaction time number correct2.54.97.12.5-2.32.52.1-2.0-2.12.72.0-1.92.2-1.92.52.3-2.21.6
Reaction time mean minus median0.30.81.31.1-0.90.91.1-1.1-1.00.71.1-1.10.9-0.80.40.7-0.11.1
Reaction time mean minus median AUC1.12.84.31.8-1.91.82.1-2.1-1.91.62.0-2.01.6-1.31.11.3-0.41.4
Reaction time num false alarms0.20.21.3-1.1-0.2-0.70.1-0.0-0.1-0.10.1-0.1-0.60.00.0-0.10.2-1.1
Reaction time num false alarms AUC0.10.21.1-1.0-0.0-0.7-0.20.20.2-0.2-0.20.2-0.4-0.2-0.30.1-0.2-0.7
Reaction time trials correct on left2.54.97.12.5-2.32.52.1-2.0-2.12.72.0-1.92.2-1.92.52.3-2.21.6
Reaction time trials on left2.64.87.12.5-2.32.52.1-2.0-2.12.72.0-2.02.2-1.92.52.3-2.21.6
Reaction time mean0.30.51.60.10.5-0.0-0.80.91.1-0.5-0.90.90.4-0.6-1.30.4-0.50.6
Reaction time mean AUC0.20.30.80.50.10.4-0.40.40.7-0.2-0.50.50.5-0.6-0.90.5-0.40.7
Median of all reaction times1.01.53.8-0.61.2-0.7-1.61.71.9-1.1-1.71.7-0.2-0.2-1.8-0.0-0.30.1
Reaction time omissions0.40.61.3-0.1-0.90.31.1-1.1-0.90.51.1-1.10.5-0.8-0.20.60.30.2
Reaction time false alarm rate1.01.43.6-1.91.0-1.6-1.01.01.1-1.4-1.01.0-1.20.7-1.4-1.01.0-1.3
Reaction time premature initiation rate1.62.38.1-2.80.6-2.3-1.21.31.7-2.0-1.41.4-0.8-0.2-2.2-0.30.4-0.4
Reaction time premature initiations0.30.51.7-1.3-0.7-0.8-0.10.20.5-0.4-0.30.30.4-1.3-0.81.0-0.80.5
Std. dev. reaction times0.71.22.71.6-1.01.51.1-1.2-0.90.91.1-1.11.3-1.0-0.10.90.01.4
Reaction time trials completed2.64.87.12.5-2.32.52.1-2.0-2.12.72.0-2.02.2-1.92.52.3-2.21.6
Reaction time trials AUC2.65.07.12.5-2.32.52.0-1.9-1.92.71.8-1.82.4-2.22.32.5-2.41.7
Run reversals in cocaine runway, females0.30.31.9-0.3-0.1-0.40.1-0.0-0.30.40.00.0-0.4-0.21.40.5-1.2-0.1
Run reversals in cocaine runway, males0.70.71.6-0.81.3-0.7-1.11.10.9-0.5-1.01.0-0.80.8-0.2-0.70.1-0.4
Latency to leave start box in cocaine runway0.10.20.4-0.3-0.30.1-0.20.20.40.1-0.30.30.4-0.7-0.50.5-0.40.6
Latency to leave start box in cocaine runway, F0.30.30.6-0.50.6-0.4-0.70.70.6-0.5-0.60.6-0.60.8-0.5-0.80.6-0.2
Latency to leave start box in cocaine runway, M1.81.76.30.0-1.60.60.7-0.6-0.10.80.4-0.41.7-2.5-0.22.3-1.81.5
Std. dev. time between licks in bursts0.91.22.41.3-1.01.11.4-1.5-1.61.01.5-1.50.60.21.1-0.10.70.6
Total sessions with >9 infusions0.80.94.30.21.10.0-0.50.30.3-0.7-0.20.2-0.61.6-1.1-1.72.1-0.8
Short access day 1 total inactive lever presses0.60.81.90.5-0.50.51.0-1.1-1.40.81.2-1.2-0.40.81.3-0.50.7-0.3
Short access day 10 total inactive lever presses0.71.63.3-1.5-1.8-1.01.2-1.0-1.10.60.9-0.9-0.1-1.61.61.7-1.8-0.2
Short access day 1 total infusions0.71.03.2-0.01.4-0.3-0.70.60.3-0.7-0.40.4-1.01.8-0.5-1.71.5-0.9
Short access day 10 total infusions0.30.41.3-0.20.8-0.3-0.40.40.5-0.7-0.30.3-0.30.6-1.2-0.81.1-0.4
Short access total infusions0.40.51.70.81.00.5-0.40.30.3-0.4-0.20.2-0.21.1-0.9-1.21.3-0.0
Short access day 1 locomotion1.01.22.7-0.61.2-0.7-1.00.90.9-1.2-0.80.8-0.91.4-1.3-1.51.7-1.0
Short access day 10 total locomotion0.71.32.91.20.20.80.8-1.0-1.40.71.1-1.1-0.71.71.6-1.31.4-0.5
Short access total locomotion0.70.85.00.10.10.10.5-0.6-0.7-0.20.8-0.8-0.61.4-0.2-1.52.2-0.8
One hour access (0.3 mA shock)1.31.56.02.0-0.21.5-0.00.10.01.2-0.20.21.5-1.30.91.7-2.51.3
Compulsive drug intake1.11.33.51.9-0.61.40.2-0.2-0.21.00.1-0.11.5-1.20.81.4-1.91.8
One hour access (shock baseline)0.00.10.4-0.30.1-0.1-0.10.10.2-0.1-0.10.10.1-0.4-0.70.3-0.1-0.4
Social response proportion1.51.77.9-1.2-1.0-0.70.10.10.7-0.2-0.30.31.3-2.8-1.22.3-1.91.0
Social responses1.31.64.7-1.20.1-0.9-0.91.11.7-1.0-1.31.20.9-2.0-2.21.4-1.10.7
Social time0.60.82.20.9-0.51.00.1-0.10.20.6-0.0-0.01.5-1.4-0.51.3-1.01.4
Soleus weight0.20.51.40.9-0.80.8-0.20.20.50.2-0.30.31.2-1.0-0.60.9-0.80.9
Bone: stiffness1.01.65.30.4-2.30.81.5-1.4-1.31.21.3-1.31.1-1.50.71.5-0.90.6
Tibialis anterior weight0.51.84.91.6-1.31.50.4-0.30.01.00.2-0.22.2-2.0-0.51.9-1.71.7
Time to tail flick, vehicle, before self-admin0.30.41.40.80.10.70.4-0.5-0.60.30.6-0.6-0.00.80.1-0.81.20.3
Time to tail flick, vehicle, after self-admin0.81.16.02.50.12.00.4-0.5-0.61.20.5-0.51.20.00.60.2-0.21.3
Time to tail flick, test, before self-admin0.10.10.5-0.0-0.20.10.0-0.10.1-0.20.1-0.10.00.1-0.7-0.30.6-0.2
Time to tail flick, test, after self-admin0.70.71.51.2-0.71.20.8-0.9-0.80.90.9-0.90.8-0.50.20.50.01.2
Delta time to tail flick, vehicle, before/after SA2.42.33.81.9-1.11.81.1-1.1-1.01.81.0-1.01.8-1.61.41.9-1.91.6
Delta time to tail flick, test, before/after SA0.20.20.90.8-0.10.70.3-0.3-0.30.40.4-0.40.5-0.10.20.20.11.0
Tibia length0.51.32.5-1.2-1.4-0.61.5-1.5-1.5-0.11.6-1.6-0.50.20.1-0.41.5-0.9
Ambulatory time before self-admin0.40.71.21.1-0.71.10.9-0.9-1.00.91.0-1.00.6-0.11.00.20.10.5
Ambulatory time after self-admin0.10.10.30.20.10.1-0.40.40.5-0.0-0.50.40.4-0.5-0.40.4-0.50.2
Bone: tissue strength0.30.30.5-0.7-0.6-0.60.6-0.5-0.70.10.6-0.6-0.60.30.7-0.20.2-0.7
Total heroin consumption0.80.92.6-0.61.2-1.0-0.70.70.4-0.8-0.60.6-1.41.60.3-1.40.8-1.0
Bone: trabecular number1.83.04.31.7-2.11.71.6-1.6-1.61.91.5-1.51.6-1.62.01.9-1.81.4
Bone: trabecular spacing0.91.24.0-0.81.1-0.6-0.80.81.0-1.2-0.70.7-0.71.0-1.9-1.42.0-0.8
Bone: trabecular thickness0.40.51.51.00.30.6-0.60.60.60.2-0.60.60.7-0.6-0.10.7-1.21.1
Bone: trabecular tissue density2.13.05.2-1.82.1-2.1-2.22.31.9-1.4-2.32.3-1.81.10.3-0.7-1.2-1.0
Water consumed over 24 hours0.20.30.70.40.1-0.0-0.50.60.8-0.4-0.60.60.6-0.5-0.90.4-0.40.6
Number of responses in last shaping day1.01.12.1-1.40.8-1.2-0.60.60.6-1.2-0.50.5-1.11.0-1.2-1.21.4-1.4