Hub : Genes

Nat10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Nat10 0.24 0.13 5.6e-14 0.12 0.12 0.12 0.12 2.2e-13 5.8e-13 2.2e-13 1.7e-13
2 Brain mRNA stability Nat10 0.21 0.11 0.0e+00 0.26 0.26 0.26 0.26 2.3e-24 5.4e-24 4.5e-24 2.3e-24
3 BLA gene expression Nat10 0.19 0.12 4.5e-10 0.17 0.17 0.17 0.18 2.0e-09 3.3e-09 1.1e-09 9.6e-10
4 NAcc gene expression Nat10 0.07 0.05 9.7e-09 0.07 0.07 0.06 0.06 3.1e-08 3.8e-08 7.8e-08 8.2e-08
5 NAcc mRNA stability Nat10 0.11 0.07 1.3e-13 0.11 0.11 0.12 0.11 3.7e-13 3.8e-13 3.6e-13 3.6e-13
6 Liver gene expression Nat10 0.1 0.07 1.9e-11 0.09 0.09 0.08 0.09 3.2e-10 4.1e-10 1.3e-09 4.6e-10
7 IL mRNA stability Nat10 0.3 0.16 4.0e-07 0.24 0.23 0.2 0.23 1.7e-06 2.3e-06 1.3e-05 3.0e-06
8 BLA mRNA stability Nat10 0.09 0.06 3.5e-05 0.06 0.09 0.06 0.03 2.2e-04 2.7e-05 2.6e-04 6.8e-03
9 Liver mRNA stability Nat10 0.04 0.04 2.8e-04 0.02 0.02 0.02 0.02 9.8e-04 1.1e-03 1.5e-03 1.5e-03
10 Brain gene expression Nat10 0.11 0.1 1.7e-06 0.07 0.05 0.07 0 4.9e-07 1.8e-05 9.3e-07 3.0e-01
11 PL gene expression Nat10 0.09 0.06 6.3e-13 0.13 0.09 0.12 0.12 2.7e-14 1.8e-10 4.9e-13 1.2e-13
12 pVTA gene expression Nat10 0.07 0.07 1.9e-03 0.04 0.03 0.01 0.02 1.0e-02 2.0e-02 7.2e-02 3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.61.01.3-1.1-1.1-1.11.11.01.00.9-1.00.91.11.00.7
Area under the delay curve0.10.20.30.50.30.3-0.5-0.2-0.2-0.50.3-0.0-0.5-0.3-0.6
BMI with tail0.10.30.6-0.4-0.5-0.70.30.50.50.7-0.50.80.40.80.1
BMI without tail0.40.91.8-0.8-0.9-1.00.80.91.00.9-0.91.20.81.30.9
Body weight0.62.54.4-1.4-1.5-1.51.31.51.41.5-1.51.61.42.12.1
Weight adjusted by age2.52.83.31.81.61.5-1.8-1.6-1.6-1.71.6-1.6-1.7-1.8-1.7
Bone surface0.71.11.5-1.2-1.1-1.11.21.01.01.0-1.01.01.11.20.9
Bone volume1.52.53.2-1.7-1.6-1.61.81.61.61.6-1.61.51.71.41.2
Breakpoint value in progressive ratio session1.31.42.21.41.31.1-1.5-1.2-1.3-1.41.2-1.0-1.5-0.8-0.3
Number of licking bursts0.30.30.5-0.6-0.7-0.70.60.60.70.5-0.60.70.50.40.2
Context. condit. distance diff. score3.13.84.1-2.0-2.0-2.01.92.02.01.8-2.02.02.01.81.9
Locomotion velocity, session 10.10.10.30.10.20.3-0.1-0.2-0.2-0.40.2-0.4-0.2-0.6-0.3
Locomotion distance, session 10.00.00.1-0.20.00.10.3-0.0-0.0-0.00.0-0.10.2-0.3-0.3
Locomotion velocity, session 20.00.00.1-0.0-0.0-0.00.10.00.0-0.2-0.00.00.00.30.2
Locomotion distance, session 20.20.30.4-0.6-0.5-0.50.70.50.40.6-0.50.50.70.50.4
Locomotion velocity, session 30.10.10.1-0.3-0.2-0.20.30.20.40.4-0.20.20.30.0-0.2
Locomotion distance, session 30.20.20.3-0.4-0.4-0.40.40.40.50.6-0.40.40.40.10.3
Stereotopy head waving bouts, day 30.10.10.30.20.30.3-0.2-0.2-0.20.00.3-0.3-0.1-0.3-0.5
Stereotopy head waving duration, day 30.40.50.9-0.7-0.7-0.70.70.80.80.6-0.70.70.60.90.6
Locomotion velocity, session 70.00.00.1-0.10.00.10.1-0.0-0.10.2-0.0-0.00.30.10.1
Locomotion distance, session 70.40.50.80.80.80.8-0.7-0.8-0.9-0.60.8-0.8-0.6-0.7-0.3
Stereotopy head waving bouts, day 70.10.10.2-0.3-0.3-0.30.40.30.40.2-0.20.30.30.3-0.1
Stereotopy head waving duration, day 70.00.10.2-0.2-0.2-0.20.30.20.30.0-0.20.20.10.50.1
Locomotion velocity, session 80.40.50.7-0.8-0.7-0.60.80.60.60.9-0.70.60.80.40.8
Locomotion distance, session 83.24.75.5-2.3-2.1-2.12.22.12.02.2-2.22.22.32.12.1
Degree of sensitization distance0.40.40.60.70.60.7-0.8-0.6-0.8-0.80.6-0.6-0.7-0.3-0.1
Degree of sensitization stereotypy0.00.00.1-0.1-0.1-0.10.20.10.2-0.1-0.00.10.10.3-0.2
Conditioned locomotion3.74.34.92.12.02.0-2.1-2.1-2.0-2.12.1-2.0-2.1-1.9-2.2
Cocaine response after cond. corrected2.52.83.31.81.81.8-1.8-1.8-1.7-1.51.8-1.8-1.5-1.3-1.5
Cocaine response after cond. not corrected0.40.50.70.80.70.7-0.8-0.7-0.7-0.70.7-0.7-0.6-0.1-0.5
Cocaine response before conditioning6.27.59.2-2.7-2.8-2.92.52.82.82.3-2.82.92.43.02.6
Saline control response0.71.01.2-1.0-1.1-1.00.91.01.10.7-1.01.00.91.11.0
Bone: connectivity density0.61.01.5-1.0-1.0-1.11.01.01.00.8-1.01.10.91.20.7
Bone: cortical apparent density0.10.10.40.20.50.4-0.0-0.5-0.6-0.10.4-0.4-0.1-0.1-0.1
Bone: cortical area0.30.41.9-0.4-0.4-0.50.40.40.30.5-0.50.50.40.91.4
Bone: cortical porosity0.50.50.90.80.70.6-0.8-0.6-0.6-0.70.7-0.6-0.8-0.9-0.8
Bone: cortical porosity0.20.20.40.60.40.4-0.6-0.4-0.4-0.50.4-0.4-0.6-0.6-0.4
Bone: cortical thickness0.10.10.80.10.0-0.1-0.0-0.0-0.10.0-0.10.2-0.10.60.9
Bone: cortical thickness3.23.74.52.12.01.9-2.0-2.0-2.0-2.11.9-1.8-1.9-1.5-1.7
Bone: cortical tissue density0.10.10.30.10.40.30.1-0.4-0.5-0.00.3-0.3-0.00.0-0.1
Condit. Reinf. active minus inactive responses1.41.62.1-1.3-1.4-1.41.21.41.41.2-1.31.41.21.10.8
Condit. Reinf. active-inactive response ratio3.13.44.0-1.9-2.0-2.01.82.02.01.7-1.92.01.71.61.5
Condit. Reinf. active responses0.50.60.8-0.8-0.9-0.90.80.90.90.7-0.80.80.80.70.3
Condit. Reinf. inactive responses0.40.50.80.70.80.8-0.7-0.8-0.8-0.70.8-0.9-0.6-0.4-0.7
Incentive salience index mean1.41.72.1-1.3-1.4-1.51.21.41.41.2-1.41.41.21.20.9
Condit. Reinf. lever presses1.11.41.8-1.2-1.3-1.31.11.31.21.0-1.21.31.11.21.0
Condit. Reinf. active minus inactive responses1.51.92.9-1.3-1.4-1.51.21.51.41.0-1.41.51.11.71.5
Condit. Reinf. active-inactive response ratio4.44.66.6-2.0-2.2-2.21.92.22.11.6-2.22.21.92.62.4
Condit. Reinf. active responses0.91.32.0-1.1-1.2-1.21.01.21.11.0-1.21.21.01.41.1
Condit. Reinf. inactive responses0.00.00.30.10.10.1-0.0-0.2-0.10.10.2-0.1-0.1-0.3-0.6
Condit. Reinf. lever presses0.70.91.3-0.9-1.0-1.10.91.11.00.7-1.01.00.81.10.7
Condit. Reinf. lever reinforcers received0.91.21.6-1.1-1.2-1.21.01.21.11.0-1.11.21.01.30.9
Conditioned reinforcement - actives4.24.26.8-1.8-1.8-2.21.91.81.71.9-1.92.41.82.52.6
Conditioned reinforcement - inactives9.310.411.2-3.3-3.3-3.33.33.23.23.2-3.23.23.23.23.1
Conditioned locomotion2.02.53.7-1.7-1.5-1.71.91.41.41.9-1.51.51.81.40.9
Patch foraging indifference point 0 sec0.40.61.80.60.60.6-0.6-0.7-0.5-0.60.7-0.8-0.5-1.2-1.3
Patch foraging indifference point AUC1.31.52.31.41.51.4-1.2-1.4-1.4-1.21.4-1.1-1.2-0.6-0.6
Delay disc. indifference point, 0s delay0.00.00.1-0.1-0.1-0.20.00.10.10.0-0.10.30.00.10.3
Delay disc. indifference point, 16s delay1.51.62.21.41.31.3-1.5-1.2-1.1-1.51.2-0.7-1.5-0.9-1.1
Delay disc. indifference point, 2s delay0.20.20.60.60.30.2-0.7-0.3-0.3-0.70.4-0.0-0.7-0.1-0.4
Delay disc. indifference point, 24s delay0.20.20.30.60.40.4-0.6-0.4-0.3-0.60.4-0.1-0.5-0.5-0.5
Delay disc. indifference point, 4s delay0.10.10.30.40.20.2-0.5-0.3-0.2-0.50.3-0.2-0.5-0.3-0.3
Delay disc. indifference point, 8s delay0.30.30.5-0.5-0.6-0.70.50.60.70.5-0.60.70.50.50.3
Indifference point function ln k0.91.21.8-1.1-1.3-1.31.01.21.21.0-1.21.01.10.70.9
Indifference point function log k0.91.21.8-1.1-1.3-1.31.01.21.21.0-1.21.01.10.70.9
Patch foraging total patch changes 0 sec0.30.51.70.50.50.5-0.4-0.5-0.4-0.50.6-0.7-0.4-1.1-1.3
Patch foraging total patch changes 12 sec0.00.00.1-0.1-0.0-0.10.30.10.20.2-0.10.10.30.3-0.0
Patch foraging total patch changes 18 sec0.30.40.80.70.90.8-0.5-0.8-0.7-0.60.8-0.5-0.5-0.4-0.5
Patch foraging total patch changes 24 sec1.11.42.21.21.31.2-1.2-1.2-1.1-1.31.3-0.9-1.1-1.0-1.5
Patch foraging total patch changes 6 sec0.30.50.80.60.70.7-0.5-0.7-0.5-0.70.8-0.5-0.6-0.7-0.9
Patch foraging time to switch 0 sec0.00.00.10.10.20.1-0.1-0.2-0.2-0.20.20.0-0.2-0.2-0.3
Patch foraging water rate 0 sec0.00.00.00.1-0.1-0.2-0.10.10.10.1-0.1-0.00.10.2-0.1
Patch foraging water rate 12 sec0.10.10.30.40.30.3-0.5-0.3-0.3-0.50.3-0.3-0.50.2-0.1
Patch foraging water rate 18 sec0.81.01.5-1.0-1.1-1.00.81.11.00.9-1.10.90.91.21.0
Patch foraging water rate 24 sec0.10.10.30.4-0.0-0.2-0.50.0-0.1-0.6-0.00.2-0.30.30.6
Patch foraging water rate 6 sec0.00.00.10.1-0.1-0.2-0.20.10.1-0.1-0.10.0-0.1-0.00.0
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.5-0.5-0.60.50.50.50.5-0.50.80.50.40.3
Distance traveled before self-admin0.50.60.9-0.7-0.6-0.60.70.70.70.9-0.70.70.80.60.9
Distance traveled after self-admin0.70.83.0-0.7-0.6-0.70.70.80.70.7-0.81.00.81.01.7
Extensor digitorum longus weight0.31.21.81.31.11.1-1.3-1.1-1.1-1.11.1-1.1-1.3-0.7-0.5
Bone: elastic displacement1.61.82.51.51.31.3-1.6-1.3-1.4-1.61.3-1.3-1.5-1.0-0.8
Bone: elastic work1.41.82.61.61.41.3-1.6-1.3-1.4-1.41.3-1.2-1.4-1.1-1.0
Bone: endosteal estimation0.20.40.80.50.60.8-0.5-0.6-0.5-0.60.6-0.9-0.5-0.8-0.7
Bone: endosteal perimeter0.30.60.7-0.8-0.8-0.70.80.80.80.8-0.80.60.90.40.5
Epididymis fat weight0.81.92.4-1.4-1.4-1.51.41.51.41.4-1.41.31.41.21.2
Delta time in closed arm before/after self-admin0.10.10.4-0.10.30.50.3-0.3-0.30.10.2-0.60.3-0.50.1
Delta time in open arm before/after self-admin0.30.31.80.30.20.1-0.5-0.3-0.2-0.40.3-0.3-0.4-0.5-1.4
Diff in mean of infusions in LGA sessions0.20.20.60.70.40.3-0.7-0.4-0.4-0.70.4-0.3-0.8-0.10.1
Delay discount exponential model param0.20.20.5-0.6-0.4-0.30.60.30.30.6-0.40.10.60.40.7
Extinction: sum of active levers before priming0.20.20.7-0.4-0.00.10.50.10.00.7-0.2-0.20.60.20.9
Active lever presses in extinction session 60.10.10.5-0.3-0.3-0.30.40.30.30.5-0.30.10.30.30.7
Bone: final force0.00.00.40.10.10.1-0.1-0.1-0.1-0.1-0.0-0.20.00.10.6
Bone: final moment0.10.20.30.40.40.5-0.4-0.4-0.5-0.40.4-0.6-0.3-0.20.3
Food consumed during 24 hour testing period7.28.710.7-2.9-2.9-2.92.93.03.02.8-3.02.92.93.03.3
Glucose2.13.14.4-1.7-1.7-1.81.61.81.71.7-1.81.71.61.92.1
Heart weight0.40.51.10.70.50.4-0.8-0.4-0.5-1.10.4-0.8-0.8-1.0-0.7
Delay discount hyperbolic model param0.10.20.3-0.5-0.3-0.20.60.20.20.5-0.30.10.50.30.6
Intermittent access intake day 1-15 change0.20.20.5-0.4-0.4-0.50.30.50.50.4-0.40.70.30.4-0.3
Intermittent access intake escalation0.50.50.9-0.7-0.7-0.80.50.80.80.6-0.70.90.50.70.1
Intermittent access intake escalation 22.82.83.5-1.7-1.7-1.71.61.81.91.6-1.71.91.51.71.3
Intermitt. access day 1 inactive lever presses0.00.00.30.00.20.2-0.0-0.1-0.2-0.10.0-0.40.0-0.10.5
Intermitt. access day 15 inactive lever presses3.03.34.6-2.0-1.7-1.62.11.71.62.1-1.81.42.21.61.7
Intermitt. access escalation Index0.60.51.5-0.4-0.7-0.90.30.60.50.1-0.71.20.21.11.1
Intermittent access day 1 total infusions3.54.14.8-2.0-2.0-2.02.11.91.82.2-1.92.12.12.02.2
Intermittent access day 15 total infusions4.95.57.4-2.3-2.4-2.42.32.32.32.4-2.32.72.22.42.0
Intermittent access terminal intake (last 3 days)6.97.69.5-2.7-2.8-2.92.62.82.82.7-2.73.12.52.92.6
Intermittent access total infusions6.87.69.3-2.7-2.8-2.92.62.82.72.7-2.73.02.52.92.7
Intermittent access day 1 locomotion1.51.62.0-1.3-1.2-1.31.41.11.11.4-1.21.31.41.21.1
Intermittent access day 15 total locomotion1.71.83.1-1.6-1.3-1.21.71.21.41.8-1.21.21.60.90.2
Intermittent access total locomotion2.12.43.7-1.7-1.6-1.61.71.51.61.9-1.51.31.81.20.8
Intermittent access standard deviation5.86.26.9-2.5-2.5-2.52.52.52.62.6-2.52.42.52.42.3
Left kidney weight0.51.53.4-1.2-0.9-1.01.31.21.11.4-1.20.71.41.41.8
Right kidney weight0.41.11.9-1.0-0.8-0.81.21.00.91.3-1.00.71.21.01.4
Cocaine induced anxiety0.30.40.5-0.7-0.6-0.50.70.70.60.7-0.60.30.70.50.6
Post-drug Anxiety0.00.00.0-0.1-0.0-0.00.0-0.1-0.2-0.1-0.0-0.10.00.0-0.0
Baseline Anxiety2.83.03.41.71.71.7-1.8-1.8-1.8-1.81.7-1.5-1.8-1.6-1.7
Tail length0.51.65.4-1.0-1.0-1.01.11.11.01.0-1.11.21.11.72.3
Length with tail0.62.26.6-1.3-1.3-1.21.31.31.21.2-1.41.31.31.92.6
Length without tail0.30.61.4-0.8-0.8-0.70.70.80.70.8-0.80.50.80.81.2
Times rat made contact with spout0.10.10.2-0.4-0.4-0.40.40.40.40.4-0.40.40.40.20.4
Lifetime Intake7.18.19.1-2.8-2.9-3.02.72.82.82.8-2.83.02.72.92.8
Liver weight, left0.30.52.0-0.5-0.5-0.50.50.70.60.4-0.60.60.51.21.4
Liver weight, right1.32.14.6-1.3-1.3-1.41.21.41.31.4-1.51.31.31.72.1
Locomotor activity0.00.10.2-0.3-0.4-0.30.20.40.40.1-0.30.10.20.1-0.2
Locomotor testing distance1.11.92.5-1.3-1.5-1.51.21.51.61.1-1.51.31.31.50.9
Locomotor testing rearing0.10.20.3-0.3-0.5-0.50.30.60.50.2-0.50.50.30.60.2
Locomotion in novel chamber0.50.61.3-0.8-1.0-1.10.60.80.70.9-0.80.80.80.70.4
Locomotion in novel chamber post-restriction1.01.21.51.11.01.0-1.2-1.0-0.9-1.21.0-1.1-1.2-1.0-1.2
Fecal boli incidents, locomotor time 17.17.810.23.12.92.7-3.1-2.9-3.0-3.02.8-2.4-3.2-2.3-1.9
Change in fecal boli incidents, locomotor task5.85.57.3-2.6-2.3-2.22.62.42.42.7-2.32.02.72.01.7
Time >=10cm from walls, locomotor time 10.10.10.20.50.30.3-0.5-0.3-0.4-0.50.30.1-0.50.10.0
Bouts of movement, locomotor time 10.70.71.41.10.90.6-1.1-0.8-0.9-1.10.8-0.2-1.2-0.3-0.2
Total resting periods, locomotor time 10.60.61.21.00.80.6-1.0-0.7-0.8-1.10.7-0.2-1.1-0.2-0.1
Rest time, locomotor task time 10.40.40.80.80.80.8-0.8-0.5-0.6-0.90.5-0.2-0.90.10.2
Distance moved, locomotor task time 12.02.23.0-1.6-1.5-1.51.71.51.51.7-1.41.01.71.11.0
Vertical activity count, locomotor time 10.20.20.3-0.5-0.4-0.50.60.40.40.6-0.3-0.00.6-0.0-0.1
Time >=10cm from walls, locomotor time 26.56.97.4-2.6-2.7-2.62.52.62.62.6-2.62.72.52.72.7
Bouts of movement, locomotor time 20.20.20.40.30.40.6-0.3-0.5-0.6-0.30.4-0.6-0.3-0.6-0.5
Total resting periods, locomotor time 20.10.10.30.30.30.4-0.2-0.4-0.5-0.30.3-0.5-0.2-0.4-0.4
Rest time, locomotor task time 22.02.22.61.61.61.6-1.5-1.5-1.4-1.41.5-1.4-1.5-1.3-1.6
Distance moved, locomotor task time 24.55.36.9-2.2-2.3-2.32.22.42.42.1-2.32.02.22.42.6
Vertical activity count, locomotor time 22.42.63.2-1.7-1.6-1.61.81.71.61.7-1.61.21.71.51.7
Light reinforcement 10.10.20.5-0.5-0.3-0.10.40.20.10.5-0.30.20.50.60.7
Light reinforcement 20.00.00.2-0.10.0-0.00.1-0.0-0.10.2-0.1-0.10.20.20.4
Bone: marrow area0.20.40.90.50.60.8-0.6-0.6-0.6-0.60.6-0.9-0.5-0.8-0.7
Bone: maximum diameter0.20.41.0-0.6-0.6-0.60.60.60.60.6-0.60.50.60.51.0
Bone: maximum force0.00.10.3-0.1-0.2-0.20.20.20.10.2-0.20.10.30.30.5
Bone: maximum moment0.00.10.10.30.30.3-0.3-0.3-0.3-0.20.2-0.4-0.1-0.10.1
Mean time between licks in bursts1.01.42.21.21.11.2-1.2-1.2-1.2-1.11.2-1.2-1.2-1.2-1.5
Mean num. licks in bursts0.00.00.00.10.20.2-0.1-0.2-0.2-0.00.1-0.2-0.0-0.10.2
Cd content in liver1.11.21.4-1.1-1.2-1.21.01.11.21.2-1.11.21.00.90.9
Co content in liver1.21.52.01.31.11.1-1.3-1.2-1.1-1.31.2-1.1-1.4-1.0-1.1
Cu content in liver0.30.40.60.70.50.5-0.8-0.5-0.5-0.70.6-0.5-0.7-0.4-0.3
Fe content in liver0.50.61.40.80.70.7-0.8-0.7-0.7-1.20.7-0.7-1.0-0.6-0.7
K content in liver2.82.83.41.71.71.8-1.7-1.7-1.7-1.31.7-1.8-1.6-1.8-1.6
Mg content in liver2.02.12.81.61.41.4-1.7-1.4-1.4-1.41.4-1.4-1.6-1.2-1.2
Mn content in liver1.92.12.41.51.51.5-1.5-1.4-1.5-1.51.4-1.6-1.5-1.4-1.2
Na content in liver0.10.10.20.30.30.3-0.3-0.2-0.2-0.40.2-0.3-0.10.10.2
Rb content in liver1.31.72.01.41.31.4-1.4-1.3-1.3-1.41.3-1.4-1.4-1.0-0.8
Se content in liver3.54.36.02.21.91.9-2.2-1.9-1.9-2.22.0-1.9-2.4-1.9-2.4
Sr content in liver0.10.10.20.20.30.3-0.2-0.3-0.3-0.30.3-0.3-0.2-0.3-0.5
Zn content in liver0.10.10.20.40.40.3-0.4-0.3-0.4-0.30.4-0.3-0.4-0.3-0.0
Bone: minimum diameter0.71.33.0-1.0-1.1-1.10.91.11.11.0-1.21.01.01.41.7
Time in familiar zone, hab. session 10.60.60.80.70.90.8-0.6-0.8-0.8-0.70.8-0.9-0.6-0.9-0.4
Time in novel zone, hab. session 11.21.21.9-1.1-1.2-1.20.91.31.40.9-1.21.10.81.10.6
Total zone transitions, hab. session 12.23.14.2-2.0-1.7-1.72.11.81.91.9-1.71.82.01.31.1
Total locomotion distance, hab. session 10.81.22.4-1.4-1.0-1.01.60.91.11.4-0.91.01.50.30.1
Locomotion velocity, hab. session 10.50.71.7-1.1-0.7-0.71.30.70.81.2-0.60.71.30.1-0.1
Time in familiar zone, hab. session 20.10.10.4-0.00.10.10.1-0.1-0.10.40.1-0.10.2-0.6-0.5
Time in novel zone, hab. session 20.20.20.8-0.1-0.3-0.30.00.40.3-0.2-0.40.3-0.10.90.9
Total zone transitions, hab. session 21.62.12.7-1.5-1.4-1.41.51.41.41.6-1.41.41.51.51.3
Total locomotion distance, hab. session 20.00.10.3-0.10.10.10.2-0.2-0.10.40.1-0.10.2-0.3-0.5
Locomotion velocity, hab. session 20.10.10.40.00.20.10.1-0.2-0.20.30.2-0.20.1-0.4-0.6
Novel to familiar place preference ratio0.70.71.2-0.9-0.9-0.90.90.90.81.1-0.90.80.90.50.3
Novelty place preference0.70.71.2-0.9-0.8-0.90.90.90.81.1-0.90.90.90.50.4
Time in novel zone, NPP test0.50.50.7-0.8-0.7-0.70.80.70.70.9-0.70.70.70.40.3
Total zone transitions, NPP test0.40.60.80.70.70.7-0.6-0.8-0.8-0.90.8-0.7-0.7-0.9-0.8
Total locomotion distance, NPP test0.50.61.40.60.80.8-0.5-0.8-0.8-0.60.9-0.8-0.6-1.1-1.2
Locomotion velocity, NPP test0.40.51.30.60.70.7-0.5-0.8-0.7-0.40.8-0.7-0.4-1.0-1.1
Intraocular pressure0.00.10.30.0-0.0-0.10.00.10.2-0.0-0.00.2-0.0-0.5-0.6
Delta distance traveled before/after self-admin0.10.20.30.30.50.3-0.3-0.5-0.5-0.50.40.1-0.30.00.5
Delta ambulatory time before/after self-admin0.10.10.30.10.30.1-0.2-0.2-0.3-0.40.20.1-0.20.20.5
Parametrial fat weight0.81.52.7-1.1-1.1-1.31.11.11.11.3-1.21.61.11.61.1
Pavlov. Cond. lever latency0.50.60.70.80.80.9-0.8-0.8-0.8-0.70.8-0.8-0.7-0.7-0.8
Pavlov. Cond. magazine entry latency0.91.11.9-1.1-1.0-1.01.01.00.91.1-1.01.01.01.01.4
Pavlov. Cond. change in total contacts0.20.20.50.50.50.5-0.5-0.5-0.5-0.40.5-0.5-0.5-0.7-0.3
Pavlov. Cond. index score0.20.30.4-0.6-0.5-0.50.60.50.50.7-0.50.50.50.40.7
Pavlov. Cond. latency score0.20.30.5-0.6-0.5-0.50.70.50.50.7-0.50.50.60.40.7
Pavlov. Cond. lever contacts0.40.40.8-0.7-0.7-0.70.70.70.60.5-0.70.60.40.60.9
Pavlov. Cond. magazine entry number0.81.01.51.00.90.9-1.0-1.0-0.9-1.11.0-0.9-1.0-1.0-1.2
Pavlov. Cond. intertrial magazine entries0.00.10.30.20.00.0-0.30.00.1-0.30.1-0.1-0.3-0.2-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.4-0.6-0.5-0.50.60.40.40.6-0.50.50.40.30.6
Pavlov. Cond. response bias0.81.01.9-1.0-0.9-0.91.00.90.90.9-1.00.90.91.11.4
Pavlov. Cond. lever latency2.33.03.51.81.91.9-1.7-1.9-1.9-1.51.8-1.9-1.6-1.6-1.5
Pavlov. Cond. magazine entry latency0.80.91.2-1.1-1.0-1.01.01.01.01.0-1.01.11.00.60.5
Pavlov. Cond. change in total contacts1.11.51.8-1.3-1.3-1.41.21.31.31.0-1.31.31.11.21.0
Pavlov. Cond. index score2.02.53.1-1.7-1.7-1.71.61.71.71.4-1.71.71.51.31.2
Pavlov. Cond. latency score2.43.03.7-1.8-1.9-1.91.71.91.81.6-1.81.91.71.51.3
Pavlov. Cond. lever contacts2.73.64.3-2.0-2.1-2.11.92.12.01.6-2.02.11.71.71.5
Pavlov. Cond. magazine entry number0.40.50.70.80.80.8-0.8-0.8-0.8-0.70.8-0.8-0.7-0.3-0.4
Pavlov. Cond. intertrial magazine entries0.00.10.10.30.30.2-0.3-0.2-0.2-0.30.2-0.2-0.2-0.00.1
Pavlov. Cond. lever-magazine prob. diff.1.72.22.7-1.5-1.6-1.61.51.61.61.3-1.51.61.31.31.1
Pavlov. Cond. response bias1.92.63.1-1.7-1.8-1.71.61.71.71.4-1.71.71.41.31.4
Time in closed arm before self-admin2.02.34.0-1.1-1.6-1.80.81.61.60.9-1.62.00.81.91.7
Time in closed arm after self-admin0.70.71.1-0.8-0.8-0.80.80.90.80.7-0.90.90.70.91.1
Time in open arm before self-admin1.51.72.11.21.41.4-1.0-1.4-1.4-1.11.4-1.5-1.1-1.4-1.1
Time in open arm after self-admin2.32.65.11.41.51.5-1.4-1.6-1.4-1.31.6-1.7-1.4-1.8-2.3
Bone: periosteal estimation0.00.00.10.20.20.3-0.2-0.2-0.2-0.20.1-0.3-0.10.00.3
Bone: periosteal perimeter1.11.82.7-1.3-1.3-1.31.31.31.31.5-1.31.31.41.31.6
Bone: post-yield work0.00.00.1-0.0-0.1-0.10.00.00.0-0.10.00.00.1-0.3-0.4
Progressive ratio test 1 active lever presses3.94.04.6-2.0-2.0-2.12.01.91.92.2-2.01.92.02.02.1
Progressive ratio test 1 breakpoint3.63.84.5-1.9-1.9-2.01.91.91.82.1-1.91.91.92.02.1
Progressive ratio test 1 inactive lever presses1.92.12.7-1.5-1.4-1.41.61.41.31.7-1.51.21.61.41.5
Progressive ratio test 2 active lever presses2.83.13.6-1.7-1.7-1.71.81.71.71.9-1.71.91.81.81.7
Progressive ratio test 2 breakpoint3.53.94.6-2.0-1.9-2.02.02.01.92.1-2.02.12.02.01.9
Progressive ratio test 2 inactive lever presses3.84.45.3-2.2-2.1-2.12.32.12.02.3-2.11.82.22.02.0
Incentive Sensitization - Responses1.21.32.0-1.1-1.0-1.11.21.11.01.2-1.11.41.11.20.9
Incentive Sensitization - Breakpoint1.01.01.6-1.0-0.9-1.01.11.01.01.1-1.01.31.11.00.8
Sum of active levers in priming session hrs 5-60.80.81.30.81.11.1-0.7-1.0-1.1-0.61.0-1.1-0.7-0.9-0.4
Progressive ratio0.30.40.6-0.6-0.5-0.60.80.70.50.8-0.70.20.70.40.7
Food seeking constrained by brief footshock1.01.21.5-1.1-1.1-1.01.21.01.01.2-1.11.01.21.11.2
Seeking ratio, punishment vs. effort0.10.20.40.40.30.4-0.5-0.5-0.3-0.40.4-0.1-0.3-0.4-0.6
Retroperitoneal fat weight8.828.832.0-5.6-5.6-5.45.45.65.75.3-5.55.05.45.14.6
Reaction time number correct0.10.10.30.1-0.1-0.4-0.30.20.2-0.3-0.20.4-0.30.60.5
Reaction time mean minus median0.10.20.4-0.4-0.4-0.20.40.30.40.6-0.40.20.40.40.3
Reaction time mean minus median AUC0.10.10.3-0.3-0.3-0.20.40.40.40.5-0.40.30.40.40.4
Reaction time num false alarms1.41.92.31.51.51.3-1.5-1.3-1.3-1.31.3-1.5-1.5-1.4-1.0
Reaction time num false alarms AUC1.92.63.31.81.71.6-1.8-1.5-1.5-1.61.6-1.8-1.8-1.5-1.3
Reaction time trials correct on left0.10.10.30.1-0.1-0.4-0.30.20.2-0.3-0.20.4-0.30.60.5
Reaction time trials on left0.10.10.20.2-0.0-0.3-0.40.10.1-0.4-0.10.3-0.40.50.4
Reaction time mean0.20.30.5-0.5-0.5-0.50.50.40.50.6-0.50.60.50.70.6
Reaction time mean AUC0.40.50.7-0.7-0.7-0.60.70.60.70.7-0.70.70.60.80.8
Median of all reaction times0.40.61.0-0.8-0.7-0.80.70.70.70.8-0.70.90.71.00.8
Reaction time omissions1.21.62.61.21.31.4-1.0-1.3-1.2-1.01.3-1.2-0.9-1.4-1.6
Reaction time false alarm rate2.53.54.61.91.91.9-1.8-1.8-1.8-1.61.9-2.1-1.8-2.0-1.8
Reaction time premature initiation rate0.10.20.40.50.40.2-0.5-0.5-0.5-0.60.4-0.3-0.5-0.50.0
Reaction time premature initiations0.10.20.50.50.30.0-0.6-0.3-0.4-0.70.3-0.1-0.6-0.10.3
Std. dev. reaction times0.00.00.0-0.1-0.10.10.20.10.20.2-0.1-0.00.10.10.1
Reaction time trials completed0.10.10.20.2-0.0-0.3-0.40.10.1-0.4-0.10.3-0.40.50.4
Reaction time trials AUC0.10.10.50.0-0.2-0.5-0.20.30.3-0.2-0.30.5-0.10.70.6
Run reversals in cocaine runway, females0.10.10.4-0.3-0.2-0.30.30.30.20.3-0.30.40.30.50.6
Run reversals in cocaine runway, males5.25.16.62.22.32.3-2.0-2.3-2.3-2.12.3-2.6-2.0-2.2-2.3
Latency to leave start box in cocaine runway0.40.41.40.30.60.5-0.0-0.5-0.5-0.20.5-1.1-0.1-1.2-1.1
Latency to leave start box in cocaine runway, F0.40.41.60.30.50.40.0-0.4-0.4-0.00.4-1.0-0.0-1.3-1.1
Latency to leave start box in cocaine runway, M0.10.10.20.20.50.5-0.1-0.5-0.5-0.30.4-0.4-0.1-0.5-0.1
Std. dev. time between licks in bursts0.30.40.90.60.50.5-0.7-0.5-0.5-0.90.5-0.5-0.8-0.6-0.5
Total sessions with >9 infusions2.42.73.6-1.5-1.6-1.91.61.61.51.5-1.61.81.41.81.9
Short access day 1 total inactive lever presses0.91.01.2-1.0-1.1-1.01.01.01.01.0-1.00.81.00.91.0
Short access day 10 total inactive lever presses0.10.20.5-0.6-0.2-0.20.70.30.20.4-0.4-0.30.6-0.00.4
Short access day 1 total infusions9.610.212.1-3.1-3.2-3.33.13.23.12.9-3.23.13.03.33.5
Short access day 10 total infusions3.94.34.9-2.0-2.2-2.22.02.22.22.1-2.02.22.02.11.7
Short access total infusions5.76.47.3-2.5-2.6-2.72.42.52.52.4-2.52.72.42.72.5
Short access day 1 locomotion3.94.25.2-2.1-2.2-2.32.02.12.11.9-2.11.82.12.01.7
Short access day 10 total locomotion3.03.35.0-2.0-1.8-1.82.21.81.92.2-1.81.32.21.41.0
Short access total locomotion3.33.44.2-1.9-2.0-2.12.01.91.91.9-1.91.61.91.71.1
One hour access (0.3 mA shock)3.23.85.9-2.1-1.8-1.82.31.81.82.4-1.81.82.31.71.3
Compulsive drug intake2.02.12.61.41.41.3-1.3-1.5-1.6-1.31.4-1.6-1.3-1.4-1.4
One hour access (shock baseline)6.67.68.5-2.9-2.8-2.72.92.82.82.9-2.72.92.82.72.2
Social response proportion4.34.65.32.32.32.2-2.2-2.2-2.3-2.32.2-2.1-2.3-1.8-1.5
Social responses0.00.10.3-0.2-0.2-0.20.20.20.20.3-0.20.10.20.10.5
Social time2.22.93.91.81.71.5-1.8-1.7-1.7-2.01.8-1.5-1.8-1.5-1.7
Soleus weight1.75.06.02.22.32.3-2.0-2.3-2.4-1.92.3-2.3-2.0-2.3-2.4
Bone: stiffness0.40.61.1-0.8-0.7-0.70.80.80.70.8-0.80.70.80.61.0
Tibialis anterior weight2.89.510.93.33.13.1-3.3-3.1-3.2-3.23.1-3.1-3.3-2.5-2.4
Time to tail flick, vehicle, before self-admin3.63.75.9-2.3-1.9-1.72.31.81.92.4-1.91.62.31.51.1
Time to tail flick, vehicle, after self-admin5.15.45.7-2.3-2.3-2.42.42.32.42.3-2.32.32.32.32.2
Time to tail flick, test, before self-admin1.51.42.1-1.3-1.4-1.21.11.31.51.0-1.30.91.11.01.1
Time to tail flick, test, after self-admin2.62.73.3-1.8-1.7-1.61.81.71.81.7-1.61.31.81.31.2
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.0-0.3-0.4-0.00.30.3-0.1-0.30.4-0.10.50.7
Delta time to tail flick, test, before/after SA0.10.10.2-0.3-0.1-0.20.40.10.00.4-0.10.40.40.2-0.1
Tibia length0.20.40.70.80.60.7-0.8-0.6-0.6-0.80.5-0.7-0.80.10.7
Ambulatory time before self-admin0.40.41.2-0.4-0.5-0.40.40.60.50.6-0.60.90.60.71.1
Ambulatory time after self-admin1.01.14.0-0.9-0.8-0.90.80.90.80.8-1.01.20.91.22.0
Bone: tissue strength0.10.10.60.20.20.4-0.1-0.2-0.2-0.10.3-0.40.0-0.8-0.8
Total heroin consumption1.11.32.01.21.41.1-1.0-1.4-1.4-1.01.3-1.1-1.0-1.0-0.8
Bone: trabecular number0.50.81.1-1.0-1.0-1.10.90.90.90.7-0.90.90.91.00.7
Bone: trabecular spacing0.10.20.4-0.4-0.3-0.30.40.40.40.6-0.40.40.50.30.4
Bone: trabecular thickness0.20.20.3-0.4-0.5-0.50.50.50.50.4-0.50.50.50.50.6
Bone: trabecular tissue density1.31.82.81.31.51.5-1.1-1.4-1.4-1.11.4-1.4-1.0-1.7-1.3
Water consumed over 24 hours0.20.20.4-0.4-0.5-0.50.40.50.50.4-0.50.50.30.40.6
Number of responses in last shaping day1.92.02.8-1.2-1.4-1.51.21.41.31.3-1.41.51.31.61.7