Nat10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Nat10 0.04 0.05 9.0e-03 0.02 0.03 0.03 0.03 5.2e-03 3.0e-03 1.2e-03 2.1e-03
2 Brain gene expression Nat10 0.12 0.1 1.3e-06 0.07 0.07 0.06 0.02 3.5e-07 8.2e-07 3.0e-06 9.1e-03
3 PL gene expression Nat10 0.09 0.06 3.9e-12 0.12 0.1 0.11 0.1 1.1e-12 1.7e-11 1.1e-11 6.0e-11
4 PL mRNA stability Nat10 0.24 0.13 3.7e-14 0.13 0.13 0.12 0.12 1.2e-13 1.1e-13 3.7e-13 3.4e-13
5 NAcc mRNA stability Nat10 0.1 0.07 0.0e+00 0.12 0.12 0.11 0.11 4.3e-17 2.3e-17 2.0e-16 2.2e-16
6 IL mRNA stability Nat10 0.32 0.18 6.8e-07 0.13 0.22 0.19 0.19 5.9e-04 5.5e-06 2.0e-05 2.2e-05
7 Liver gene expression Nat10 0.1 0.08 5.4e-12 0.09 0.09 0.09 0.09 2.3e-10 1.2e-10 3.4e-10 1.8e-10
8 Brain mRNA stability Nat10 0.22 0.12 0.0e+00 0.25 0.26 0.25 0.25 2.5e-23 1.8e-24 1.7e-23 1.5e-23
9 pVTA gene expression Nat10 0.05 0.04 4.2e-05 0.05 0.06 0.04 0.05 1.1e-04 1.9e-05 5.7e-04 8.1e-05
10 IC mRNA stability Nat10 0.07 0.06 4.7e-03 0.05 0.05 0.04 0.04 4.9e-03 3.7e-03 6.3e-03 6.5e-03
11 IC gene expression Nat10 0.2 0.15 2.5e-05 0.07 0.09 0.06 0.08 5.9e-04 1.2e-04 1.2e-03 4.3e-04
12 BLA gene expression Nat10 0.2 0.13 1.3e-10 0.17 0.18 0.18 0.18 2.7e-09 8.6e-10 8.9e-10 6.6e-10
13 NAcc gene expression Nat10 0.08 0.05 3.7e-11 0.07 0.07 0.06 0.07 1.6e-11 1.0e-10 1.3e-09 5.8e-11
14 Liver mRNA stability Nat10 0.04 0.04 3.7e-04 0.02 0.02 0.02 0.02 1.0e-03 2.7e-03 2.5e-03 1.8e-03
15 BLA mRNA stability Nat10 0.09 0.06 9.9e-05 0.06 0.05 0.04 0.05 6.6e-04 1.2e-03 3.1e-03 8.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.71.22.00.1-1.1-1.0-1.4-1.1-1.0-1.0-1.2-0.9-0.9-1.2-1.1-1.3-1.2-1.2
Area under the delay curve0.20.22.11.50.3-0.1-0.10.20.30.30.10.30.30.10.10.40.10.2
BMI with tail0.10.40.50.40.60.40.60.70.70.70.70.70.70.70.70.60.70.5
BMI without tail0.00.10.4-0.4-0.1-0.70.3-0.3-0.5-0.5-0.1-0.5-0.5-0.1-0.2-0.2-0.2-0.3
Body weight0.20.91.4-0.9-0.9-1.2-0.4-0.9-1.1-1.1-0.8-1.2-1.2-0.7-0.8-0.9-0.8-0.8
Weight adjusted by age2.13.24.50.72.11.91.71.81.81.81.81.81.81.81.72.01.81.9
Bone surface0.71.21.91.0-1.1-1.0-1.4-1.0-0.9-0.9-1.1-0.9-0.9-1.2-1.1-1.3-1.1-1.3
Bone volume1.52.64.10.0-1.8-1.5-2.0-1.6-1.5-1.5-1.7-1.4-1.4-1.8-1.7-1.9-1.7-1.9
Breakpoint value in progressive ratio session1.51.83.10.91.41.21.81.41.21.21.51.21.21.51.41.41.51.3
Number of licking bursts0.20.40.70.2-0.5-0.6-0.9-0.6-0.5-0.5-0.7-0.5-0.5-0.7-0.7-0.5-0.7-0.5
Context. condit. distance diff. score3.74.59.1-3.0-1.9-1.9-1.8-2.1-2.2-2.2-2.0-2.2-2.2-2.0-2.1-2.1-2.0-2.0
Locomotion velocity, session 10.10.10.2-0.30.40.30.20.30.30.30.30.30.30.30.30.20.20.1
Locomotion distance, session 10.10.10.60.80.10.1-0.40.10.20.2-0.10.20.2-0.1-0.0-0.1-0.0-0.2
Locomotion velocity, session 20.10.10.91.00.30.1-0.00.00.10.0-0.00.10.1-0.10.00.0-0.1-0.0
Locomotion distance, session 20.20.30.5-0.1-0.6-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.7-0.5-0.6
Locomotion velocity, session 30.20.21.91.4-0.3-0.1-0.7-0.10.10.1-0.30.10.1-0.3-0.2-0.4-0.3-0.4
Locomotion distance, session 30.10.20.40.2-0.4-0.3-0.6-0.3-0.2-0.3-0.4-0.2-0.2-0.5-0.4-0.5-0.5-0.5
Stereotopy head waving bouts, day 30.10.21.21.1-0.10.3-0.10.40.40.40.20.50.50.20.30.10.30.1
Stereotopy head waving duration, day 30.30.30.5-0.0-0.6-0.5-0.7-0.5-0.5-0.5-0.6-0.5-0.5-0.6-0.6-0.6-0.6-0.7
Locomotion velocity, session 70.10.11.0-1.0-0.3-0.00.1-0.1-0.2-0.2-0.0-0.2-0.2-0.0-0.1-0.2-0.0-0.2
Locomotion distance, session 70.40.51.3-1.10.50.80.90.60.50.60.70.50.50.80.70.60.80.6
Stereotopy head waving bouts, day 70.20.23.11.8-0.1-0.2-0.4-0.00.10.1-0.10.10.1-0.2-0.1-0.3-0.1-0.4
Stereotopy head waving duration, day 70.20.22.61.6-0.0-0.2-0.3-0.00.0-0.0-0.20.00.0-0.2-0.1-0.3-0.1-0.3
Locomotion velocity, session 80.60.72.7-1.6-0.8-0.6-0.5-0.7-0.8-0.8-0.7-0.8-0.8-0.7-0.7-0.9-0.6-0.9
Locomotion distance, session 83.24.75.5-2.4-2.2-2.0-2.1-2.2-2.2-2.2-2.1-2.2-2.2-2.1-2.1-2.3-2.0-2.2
Degree of sensitization distance0.50.53.5-1.90.60.61.00.40.20.20.60.10.10.70.50.70.60.7
Degree of sensitization stereotypy0.30.34.42.10.0-0.1-0.40.10.20.1-0.10.20.2-0.1-0.0-0.3-0.1-0.3
Conditioned locomotion4.24.811.43.42.12.11.62.12.32.22.02.32.31.92.12.02.02.1
Cocaine response after cond. corrected2.93.54.62.11.61.91.71.91.91.91.91.91.91.91.91.81.91.9
Cocaine response after cond. not corrected0.80.92.61.60.80.80.90.90.90.90.90.90.90.90.91.00.91.0
Cocaine response before conditioning5.86.98.2-1.6-2.2-2.9-2.5-2.8-2.8-2.8-2.7-2.8-2.8-2.7-2.8-2.5-2.8-2.5
Saline control response0.71.01.40.5-0.8-1.0-1.2-1.0-0.9-1.0-1.1-0.9-0.9-1.2-1.1-0.9-1.1-1.0
Bone: connectivity density0.60.91.40.6-0.9-1.0-1.2-0.9-0.9-0.9-1.0-0.8-0.8-1.0-1.0-1.1-1.0-1.1
Bone: cortical apparent density0.10.21.5-1.2-0.20.10.40.1-0.1-0.00.2-0.1-0.10.30.2-0.30.3-0.3
Bone: cortical area0.30.41.6-1.3-0.5-0.6-0.0-0.6-0.8-0.8-0.5-0.8-0.8-0.4-0.5-0.5-0.5-0.4
Bone: cortical porosity0.10.10.20.40.40.40.20.30.40.40.30.40.40.30.30.30.20.4
Bone: cortical porosity0.10.20.30.20.60.40.40.40.40.40.40.40.40.30.40.50.30.6
Bone: cortical thickness0.00.00.3-0.50.0-0.10.4-0.1-0.2-0.20.0-0.3-0.30.10.0-0.10.10.0
Bone: cortical thickness3.44.04.81.72.21.92.12.02.01.92.01.91.92.02.02.12.02.1
Bone: cortical tissue density0.10.11.4-1.2-0.20.10.40.1-0.1-0.10.2-0.1-0.10.30.2-0.30.3-0.3
Condit. Reinf. active minus inactive responses1.71.92.3-1.0-1.2-1.4-1.5-1.4-1.4-1.4-1.5-1.4-1.4-1.5-1.5-1.3-1.5-1.3
Condit. Reinf. active-inactive response ratio3.53.74.0-1.9-1.7-2.0-1.8-2.0-2.0-2.0-1.9-2.0-2.0-1.9-1.9-1.9-2.0-1.9
Condit. Reinf. active responses0.60.71.1-0.2-0.7-0.9-1.0-0.9-0.8-0.9-0.9-0.8-0.8-0.9-0.9-0.8-0.9-0.8
Condit. Reinf. inactive responses0.50.61.41.20.60.70.70.80.80.80.80.80.80.80.70.70.90.7
Incentive salience index mean1.51.92.2-1.0-1.1-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.2-1.5-1.3
Condit. Reinf. lever presses0.81.21.4-0.8-0.8-1.2-1.0-1.1-1.1-1.2-1.1-1.2-1.2-1.1-1.1-0.9-1.1-1.0
Condit. Reinf. active minus inactive responses1.21.51.9-1.2-0.8-1.3-1.1-1.3-1.4-1.4-1.2-1.4-1.4-1.2-1.3-1.0-1.3-1.0
Condit. Reinf. active-inactive response ratio3.54.15.1-1.7-1.5-2.2-1.7-2.1-2.2-2.2-2.1-2.3-2.2-2.0-2.1-1.8-2.1-1.8
Condit. Reinf. active responses0.60.91.1-0.6-0.8-1.1-0.9-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.8-1.0-0.8
Condit. Reinf. inactive responses0.10.21.31.10.00.2-0.10.30.40.40.30.50.50.20.30.20.30.2
Condit. Reinf. lever presses0.81.22.2-1.5-0.7-1.1-0.9-1.1-1.1-1.1-1.0-1.1-1.1-1.0-1.1-0.8-1.1-0.9
Condit. Reinf. lever reinforcers received0.60.91.1-0.7-0.8-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.8-1.0-0.8
Conditioned reinforcement - actives2.84.87.8-1.5-2.2-2.8-1.7-2.2-2.3-2.3-2.1-2.4-2.4-2.1-2.2-2.0-2.1-1.9
Conditioned reinforcement - inactives5.88.59.5-1.9-3.1-3.0-3.1-3.0-2.9-2.9-3.0-2.9-2.9-3.0-3.0-2.9-3.0-2.8
Conditioned locomotion1.11.42.4-0.2-1.5-1.5-1.4-1.1-1.1-1.1-1.2-1.0-1.1-1.2-1.2-1.4-1.1-1.2
Patch foraging indifference point 0 sec0.50.97.12.70.50.7-0.20.70.90.90.41.01.00.40.50.60.40.6
Patch foraging indifference point AUC1.11.62.51.31.00.91.61.31.21.21.41.11.11.41.21.21.51.3
Delay disc. indifference point, 0s delay0.00.00.1-0.1-0.1-0.4-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.2
Delay disc. indifference point, 16s delay1.51.72.31.31.40.71.41.31.31.31.31.31.31.31.31.51.11.4
Delay disc. indifference point, 2s delay0.20.20.70.90.80.20.40.40.40.40.40.30.40.40.30.80.40.6
Delay disc. indifference point, 24s delay0.20.31.61.30.50.10.30.40.50.40.30.50.50.30.30.60.20.5
Delay disc. indifference point, 4s delay0.20.20.80.90.60.40.30.40.50.40.30.40.50.30.30.60.30.5
Delay disc. indifference point, 8s delay0.40.51.21.1-0.6-0.7-1.0-0.6-0.5-0.5-0.7-0.5-0.4-0.8-0.8-0.5-0.7-0.6
Indifference point function ln k0.81.32.0-0.4-1.1-0.9-1.4-1.2-1.2-1.2-1.3-1.2-1.1-1.3-1.2-1.0-1.3-1.1
Indifference point function log k0.81.32.0-0.4-1.1-0.9-1.4-1.2-1.2-1.2-1.3-1.2-1.1-1.3-1.2-1.0-1.3-1.1
Patch foraging total patch changes 0 sec0.40.88.22.90.30.6-0.40.50.80.80.30.90.90.20.40.50.30.5
Patch foraging total patch changes 12 sec0.00.00.40.7-0.2-0.2-0.2-0.1-0.0-0.0-0.10.0-0.0-0.1-0.1-0.2-0.0-0.0
Patch foraging total patch changes 18 sec0.81.28.42.90.60.40.60.91.01.00.81.01.00.80.70.71.00.8
Patch foraging total patch changes 24 sec1.11.96.42.51.20.80.91.31.51.41.21.51.51.21.21.31.31.3
Patch foraging total patch changes 6 sec0.71.07.32.70.70.50.30.81.00.90.71.01.00.70.70.70.90.6
Patch foraging time to switch 0 sec0.00.00.4-0.60.2-0.10.10.10.10.10.10.10.10.10.1-0.00.1-0.0
Patch foraging water rate 0 sec0.00.11.31.1-0.10.0-0.3-0.00.10.1-0.10.10.1-0.1-0.20.1-0.10.1
Patch foraging water rate 12 sec0.10.20.50.20.60.50.60.40.30.30.50.30.30.50.40.70.50.6
Patch foraging water rate 18 sec0.71.01.4-1.2-1.0-0.8-0.9-1.1-1.1-1.1-1.0-1.1-1.1-1.0-1.0-0.9-1.1-0.9
Patch foraging water rate 24 sec0.10.21.3-1.20.40.10.5-0.0-0.1-0.10.2-0.2-0.20.2-0.10.50.20.5
Patch foraging water rate 6 sec0.00.00.00.10.10.2-0.0-0.00.00.0-0.00.00.0-0.0-0.20.20.00.1
Seeking ratio, delayed vs. immediate footshock0.20.31.8-1.3-0.3-0.6-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.3-0.3-0.3
Distance traveled before self-admin0.00.00.2-0.4-0.30.20.10.0-0.00.00.1-0.0-0.00.10.0-0.0-0.00.3
Distance traveled after self-admin0.10.21.7-1.3-0.0-0.30.4-0.2-0.3-0.3-0.0-0.4-0.40.0-0.10.0-0.20.1
Extensor digitorum longus weight0.31.12.51.61.10.81.11.01.00.90.90.90.90.90.91.20.91.2
Bone: elastic displacement1.41.62.30.61.41.21.51.21.11.11.31.11.11.31.21.51.31.5
Bone: elastic work1.21.62.60.11.41.31.61.21.11.21.31.11.11.41.31.51.31.6
Bone: endosteal estimation0.10.20.30.50.50.50.30.40.50.50.40.50.50.40.50.50.40.5
Bone: endosteal perimeter0.40.81.0-0.5-0.9-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.9-0.9-1.0-0.9
Epididymis fat weight1.03.34.0-1.5-1.7-1.7-1.7-1.9-2.0-2.0-1.9-2.0-2.0-1.9-1.9-1.6-1.9-1.7
Delta time in closed arm before/after self-admin0.40.40.60.20.30.80.70.70.60.60.70.60.60.70.70.10.70.4
Delta time in open arm before/after self-admin0.50.51.80.1-0.7-0.7-1.3-0.6-0.4-0.4-0.8-0.3-0.3-0.8-0.8-0.6-0.9-0.7
Diff in mean of infusions in LGA sessions1.11.32.00.21.40.91.41.11.11.11.21.01.01.21.21.41.11.3
Delay discount exponential model param0.20.22.3-1.5-0.4-0.0-0.0-0.3-0.4-0.3-0.2-0.4-0.4-0.1-0.1-0.5-0.1-0.3
Extinction: sum of active levers before priming0.30.40.8-0.40.10.80.90.60.50.50.70.40.40.80.80.40.80.5
Active lever presses in extinction session 60.00.00.10.1-0.30.00.0-0.1-0.1-0.1-0.0-0.1-0.1-0.0-0.0-0.2-0.1-0.0
Bone: final force0.10.22.4-1.6-0.2-0.00.2-0.3-0.4-0.3-0.1-0.4-0.4-0.1-0.1-0.2-0.2-0.1
Bone: final moment0.10.21.9-1.40.00.30.50.0-0.1-0.10.2-0.1-0.10.20.20.10.10.2
Food consumed during 24 hour testing period6.18.49.5-2.5-2.9-2.9-2.6-3.0-3.1-3.1-2.9-3.1-3.1-2.9-2.9-2.8-2.9-2.8
Glucose2.33.75.3-2.3-1.8-2.1-1.5-2.0-2.1-2.0-1.8-2.1-2.1-1.8-1.9-1.7-1.9-1.6
Heart weight0.60.91.9-0.31.41.11.00.90.90.90.90.80.90.90.91.10.91.0
Delay discount hyperbolic model param0.20.32.1-1.5-0.5-0.1-0.1-0.3-0.4-0.4-0.2-0.4-0.4-0.2-0.2-0.5-0.2-0.4
Intermittent access intake day 1-15 change0.40.91.4-0.9-1.0-1.0-1.2-0.9-0.9-0.9-1.0-0.8-0.8-1.0-1.0-0.8-1.0-0.8
Intermittent access intake escalation0.61.21.9-0.8-1.2-1.3-1.4-1.1-1.0-1.1-1.2-1.0-1.0-1.2-1.2-0.9-1.2-1.0
Intermittent access intake escalation 22.22.53.2-1.5-1.6-1.8-1.7-1.6-1.5-1.5-1.6-1.5-1.5-1.6-1.6-1.5-1.6-1.5
Intermitt. access day 1 inactive lever presses0.10.44.6-2.1-0.1-0.30.2-0.3-0.5-0.4-0.2-0.5-0.5-0.1-0.2-0.2-0.2-0.1
Intermitt. access day 15 inactive lever presses0.51.02.0-1.4-1.2-0.7-0.8-0.9-1.0-0.9-0.9-1.0-1.0-0.9-0.8-1.2-0.9-1.0
Intermitt. access escalation Index0.10.20.60.50.0-0.8-0.3-0.4-0.3-0.4-0.4-0.3-0.3-0.4-0.5-0.2-0.4-0.3
Intermittent access day 1 total infusions2.64.25.50.1-2.3-2.3-2.1-2.1-2.0-2.0-2.1-2.0-2.0-2.2-2.1-2.3-2.1-2.2
Intermittent access day 15 total infusions3.75.67.4-0.7-2.5-2.6-2.7-2.4-2.3-2.3-2.5-2.2-2.2-2.6-2.5-2.3-2.5-2.4
Intermittent access terminal intake (last 3 days)3.95.26.9-0.7-2.3-2.6-2.5-2.3-2.2-2.3-2.4-2.2-2.2-2.4-2.4-2.2-2.3-2.3
Intermittent access total infusions4.95.88.0-0.2-2.4-2.8-2.6-2.5-2.3-2.4-2.6-2.3-2.3-2.6-2.6-2.4-2.5-2.3
Intermittent access day 1 locomotion1.72.23.30.3-1.8-1.7-1.8-1.4-1.3-1.3-1.6-1.3-1.3-1.6-1.5-1.8-1.5-1.4
Intermittent access day 15 total locomotion0.91.64.20.7-1.7-1.1-2.0-1.1-0.9-0.9-1.4-0.8-0.8-1.4-1.3-1.5-1.3-1.3
Intermittent access total locomotion1.82.14.20.2-1.8-1.5-2.1-1.4-1.2-1.2-1.6-1.1-1.1-1.6-1.5-1.6-1.5-1.4
Intermittent access standard deviation2.14.35.7-1.4-2.4-2.1-2.2-2.1-2.1-2.1-2.1-2.1-2.1-2.1-2.1-2.2-2.1-2.0
Left kidney weight0.63.06.5-2.5-1.9-1.4-0.9-1.7-1.9-1.9-1.5-2.0-2.0-1.4-1.4-1.7-1.6-1.6
Right kidney weight1.04.78.3-2.9-2.5-1.8-1.6-2.1-2.3-2.3-2.0-2.3-2.4-1.9-2.0-2.2-2.0-2.1
Cocaine induced anxiety0.10.20.5-0.50.40.70.70.30.20.30.50.20.20.50.50.30.40.3
Post-drug Anxiety1.81.92.81.51.71.41.61.31.21.21.41.21.21.41.41.41.31.2
Baseline Anxiety1.21.410.23.21.30.50.40.91.01.00.71.01.00.60.71.10.70.8
Tail length0.52.03.4-1.2-1.2-1.7-0.6-1.5-1.7-1.7-1.3-1.8-1.8-1.3-1.4-1.2-1.3-1.1
Length with tail0.83.65.3-1.5-1.7-2.1-1.2-2.0-2.2-2.2-1.8-2.3-2.3-1.8-1.9-1.7-1.9-1.6
Length without tail0.62.12.8-0.9-1.7-1.4-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.4
Times rat made contact with spout0.20.20.40.0-0.5-0.6-0.4-0.4-0.4-0.4-0.5-0.4-0.4-0.5-0.5-0.3-0.4-0.4
Lifetime Intake4.55.57.3-0.3-2.4-2.7-2.5-2.4-2.3-2.4-2.5-2.3-2.3-2.5-2.5-2.3-2.4-2.3
Liver weight, left1.22.06.3-2.5-1.3-1.2-0.8-1.4-1.5-1.5-1.2-1.6-1.6-1.2-1.2-1.2-1.3-1.1
Liver weight, right1.22.18.7-2.9-1.4-1.0-0.7-1.3-1.5-1.5-1.1-1.5-1.6-1.1-1.1-1.2-1.2-1.2
Locomotor activity0.00.10.20.20.1-0.1-0.5-0.3-0.2-0.2-0.3-0.1-0.1-0.3-0.2-0.1-0.4-0.2
Locomotor testing distance1.01.92.2-0.9-1.0-1.4-1.4-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.4-1.1-1.5-1.2
Locomotor testing rearing0.10.30.4-0.6-0.2-0.6-0.5-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.5-0.3-0.6-0.3
Locomotion in novel chamber1.21.52.60.1-1.3-1.2-1.6-1.2-1.1-1.1-1.3-1.0-1.0-1.3-1.3-1.3-1.3-1.4
Locomotion in novel chamber post-restriction0.60.92.11.41.20.90.80.90.90.90.80.90.90.80.91.20.90.9
Fecal boli incidents, locomotor time 15.17.310.41.23.02.43.22.82.62.62.92.52.52.92.72.92.73.1
Change in fecal boli incidents, locomotor task5.95.89.8-0.2-2.8-2.1-3.1-2.4-2.2-2.2-2.6-2.1-2.1-2.7-2.5-2.7-2.5-2.7
Time >=10cm from walls, locomotor time 10.10.10.4-0.00.5-0.30.60.30.20.20.40.20.20.40.30.40.30.3
Bouts of movement, locomotor time 10.40.51.10.61.0-0.01.10.60.50.50.70.40.40.70.51.00.70.9
Total resting periods, locomotor time 10.40.41.20.11.0-0.01.10.50.40.40.60.30.30.60.40.90.60.9
Rest time, locomotor task time 10.40.51.30.51.00.31.20.60.40.40.70.40.30.70.60.90.61.0
Distance moved, locomotor task time 11.32.02.6-1.4-1.6-1.0-1.6-1.4-1.4-1.4-1.4-1.3-1.3-1.4-1.3-1.6-1.4-1.6
Vertical activity count, locomotor time 10.10.20.5-0.2-0.50.0-0.7-0.3-0.2-0.2-0.4-0.2-0.2-0.4-0.3-0.6-0.4-0.7
Time >=10cm from walls, locomotor time 24.56.67.7-2.1-2.5-2.8-2.4-2.6-2.6-2.6-2.5-2.6-2.7-2.5-2.5-2.6-2.6-2.7
Bouts of movement, locomotor time 20.20.30.7-0.80.40.80.80.50.40.50.60.40.40.70.60.40.60.4
Total resting periods, locomotor time 20.10.20.5-0.70.30.60.70.40.30.30.50.30.30.50.40.30.50.3
Rest time, locomotor task time 21.82.24.22.11.31.41.41.51.51.51.41.51.51.41.41.51.41.6
Distance moved, locomotor task time 24.85.76.7-2.0-2.1-2.2-2.2-2.5-2.6-2.6-2.4-2.6-2.6-2.4-2.4-2.3-2.5-2.5
Vertical activity count, locomotor time 22.13.04.0-1.9-1.6-1.4-1.6-1.7-1.8-1.7-1.7-1.7-1.7-1.7-1.6-2.0-1.7-2.0
Light reinforcement 10.10.31.8-1.3-0.5-0.4-0.0-0.5-0.6-0.6-0.3-0.6-0.7-0.3-0.3-0.5-0.4-0.5
Light reinforcement 20.30.55.7-2.4-0.3-0.10.3-0.3-0.5-0.4-0.1-0.5-0.5-0.0-0.1-0.3-0.2-0.2
Bone: marrow area0.10.20.30.60.50.50.30.50.50.50.40.50.50.40.50.50.40.5
Bone: maximum diameter0.30.61.8-1.3-0.6-0.8-0.4-0.7-0.8-0.8-0.6-0.8-0.8-0.6-0.6-0.7-0.6-0.6
Bone: maximum force0.20.30.8-0.9-0.6-0.3-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.4
Bone: maximum moment0.00.00.4-0.6-0.20.20.1-0.1-0.2-0.1-0.0-0.1-0.1-0.00.0-0.1-0.1-0.0
Mean time between licks in bursts0.61.52.51.61.11.20.91.21.31.31.11.31.31.11.11.11.11.1
Mean num. licks in bursts0.00.00.1-0.3-0.10.00.30.10.00.00.2-0.0-0.00.20.20.00.20.1
Cd content in liver3.53.98.0-2.8-1.5-1.8-1.5-2.0-2.1-2.1-1.9-2.1-2.1-1.8-1.9-1.9-1.9-1.9
Co content in liver1.11.31.81.31.21.01.11.11.21.11.11.11.11.11.11.21.11.2
Cu content in liver1.01.11.60.31.31.21.21.01.01.01.11.01.01.11.11.31.01.3
Fe content in liver0.20.30.80.10.90.50.70.50.50.40.50.40.40.50.50.60.50.6
K content in liver4.03.94.71.21.62.21.92.02.02.12.12.12.02.12.11.92.11.9
Mg content in liver1.21.31.80.51.11.21.41.11.01.01.21.01.01.21.11.31.11.3
Mn content in liver1.31.52.50.01.31.21.61.21.11.11.31.01.01.31.31.41.21.4
Na content in liver0.10.10.5-0.7-0.3-0.30.1-0.4-0.5-0.5-0.3-0.5-0.5-0.2-0.3-0.3-0.2-0.3
Rb content in liver1.92.23.20.41.51.71.81.51.41.41.61.31.31.61.61.61.61.6
Se content in liver4.65.56.62.52.62.22.02.32.42.42.22.42.42.22.22.52.22.5
Sr content in liver0.10.10.30.50.20.30.20.30.30.30.30.30.30.30.30.10.30.1
Zn content in liver0.40.41.2-1.1-0.7-0.5-0.5-0.6-0.6-0.6-0.5-0.6-0.6-0.5-0.6-0.5-0.6-0.5
Bone: minimum diameter0.81.52.0-0.7-1.1-1.3-0.8-1.3-1.4-1.4-1.2-1.4-1.4-1.2-1.2-1.1-1.2-1.0
Time in familiar zone, hab. session 10.60.60.90.20.70.70.90.90.80.80.90.80.80.90.90.50.90.6
Time in novel zone, hab. session 11.21.21.6-1.0-0.9-1.1-1.2-1.2-1.2-1.2-1.2-1.1-1.1-1.2-1.2-0.8-1.3-0.8
Total zone transitions, hab. session 12.12.94.3-0.8-1.8-1.6-2.1-1.7-1.6-1.6-1.8-1.5-1.5-1.8-1.8-1.9-1.8-1.9
Total locomotion distance, hab. session 10.91.33.41.5-1.4-0.8-1.8-0.8-0.6-0.6-1.1-0.5-0.5-1.2-1.0-1.5-1.0-1.5
Locomotion velocity, hab. session 10.60.82.51.5-1.2-0.6-1.6-0.6-0.3-0.3-0.8-0.2-0.2-0.9-0.8-1.2-0.7-1.2
Time in familiar zone, hab. session 20.00.00.1-0.0-0.40.0-0.30.10.20.20.10.30.20.10.1-0.20.1-0.2
Time in novel zone, hab. session 20.10.10.5-0.70.3-0.20.2-0.4-0.5-0.5-0.3-0.6-0.6-0.3-0.30.1-0.30.0
Total zone transitions, hab. session 21.41.82.4-0.6-1.6-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.3-1.3-1.4-1.3
Total locomotion distance, hab. session 20.10.11.61.3-0.30.1-0.20.20.30.20.10.30.30.00.1-0.10.1-0.1
Locomotion velocity, hab. session 20.10.21.91.4-0.30.1-0.20.20.30.30.10.40.40.10.20.00.20.0
Novel to familiar place preference ratio0.80.91.2-1.0-1.1-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.9
Novelty place preference0.80.91.3-1.2-1.1-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.9
Time in novel zone, NPP test0.70.71.5-1.2-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.8
Total zone transitions, NPP test0.60.93.11.81.00.90.50.91.01.00.71.01.00.70.80.80.80.8
Total locomotion distance, NPP test0.71.05.52.30.60.90.20.91.11.10.71.11.10.60.80.60.80.6
Locomotion velocity, NPP test0.70.95.82.40.40.80.10.81.01.00.61.11.10.60.70.60.70.6
Intraocular pressure0.00.00.1-0.10.2-0.0-0.20.10.10.10.00.20.20.00.00.2-0.00.3
Delta distance traveled before/after self-admin0.20.21.0-0.50.7-0.21.00.30.10.10.50.00.00.50.40.40.40.3
Delta ambulatory time before/after self-admin0.10.21.2-1.10.3-0.40.6-0.1-0.3-0.30.1-0.3-0.40.10.00.0-0.1-0.2
Parametrial fat weight0.10.20.3-0.3-0.6-0.5-0.5-0.4-0.3-0.3-0.4-0.3-0.3-0.4-0.5-0.4-0.4-0.4
Pavlov. Cond. lever latency0.60.70.90.70.80.70.70.90.91.00.91.01.00.90.80.70.90.9
Pavlov. Cond. magazine entry latency0.91.24.4-2.1-1.0-0.8-0.5-1.0-1.2-1.1-0.9-1.2-1.2-0.8-0.9-1.0-0.9-1.1
Pavlov. Cond. change in total contacts0.20.20.4-0.30.40.50.60.40.30.30.40.30.30.50.50.50.40.4
Pavlov. Cond. index score0.40.51.5-1.2-0.7-0.4-0.3-0.6-0.7-0.7-0.6-0.8-0.8-0.6-0.5-0.6-0.6-0.7
Pavlov. Cond. latency score0.40.51.7-1.3-0.8-0.5-0.3-0.7-0.8-0.7-0.6-0.8-0.8-0.6-0.5-0.6-0.6-0.8
Pavlov. Cond. lever contacts0.60.70.9-0.9-0.7-0.7-0.6-0.9-0.9-0.9-0.8-1.0-1.0-0.8-0.8-0.7-0.9-0.9
Pavlov. Cond. magazine entry number1.11.45.02.21.10.90.51.11.31.20.91.31.30.90.91.01.01.1
Pavlov. Cond. intertrial magazine entries0.10.11.31.10.30.0-0.30.10.20.2-0.10.20.2-0.1-0.10.2-0.10.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-1.0-0.7-0.4-0.4-0.6-0.7-0.7-0.6-0.7-0.7-0.6-0.5-0.6-0.6-0.7
Pavlov. Cond. response bias1.01.22.4-1.6-1.1-0.9-0.7-1.1-1.2-1.2-1.0-1.2-1.3-1.0-1.0-1.1-1.0-1.2
Pavlov. Cond. lever latency1.92.63.11.81.21.71.61.71.61.61.61.61.61.61.71.31.71.4
Pavlov. Cond. magazine entry latency0.80.91.2-1.1-0.9-1.1-1.1-1.0-0.9-0.9-1.0-0.9-0.9-1.0-1.0-0.8-1.0-0.9
Pavlov. Cond. change in total contacts0.91.51.9-0.7-1.0-1.4-1.3-1.3-1.2-1.2-1.3-1.2-1.2-1.3-1.3-1.0-1.3-1.1
Pavlov. Cond. index score1.92.63.3-1.5-1.4-1.8-1.7-1.7-1.6-1.6-1.7-1.6-1.6-1.7-1.7-1.4-1.7-1.5
Pavlov. Cond. latency score2.33.13.9-1.3-1.6-2.0-1.9-1.8-1.7-1.8-1.8-1.7-1.7-1.8-1.9-1.5-1.9-1.6
Pavlov. Cond. lever contacts2.73.74.4-2.0-1.6-2.1-2.0-2.0-1.9-1.9-2.0-1.9-1.9-2.0-2.0-1.7-2.0-1.8
Pavlov. Cond. magazine entry number0.81.02.31.50.91.11.01.00.90.90.90.90.90.91.00.81.00.9
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.00.50.50.60.40.40.40.50.40.40.50.50.40.50.5
Pavlov. Cond. lever-magazine prob. diff.1.62.22.8-1.5-1.2-1.7-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.6-1.2-1.6-1.3
Pavlov. Cond. response bias2.33.15.8-2.4-1.4-1.9-1.6-1.8-1.8-1.8-1.7-1.8-1.8-1.7-1.8-1.5-1.8-1.5
Time in closed arm before self-admin2.63.34.8-2.1-1.2-2.2-1.5-1.9-1.9-2.0-1.9-2.0-2.0-1.9-1.9-1.2-1.9-1.3
Time in closed arm after self-admin0.60.70.9-1.0-0.5-0.8-0.7-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.8-0.9-0.5
Time in open arm before self-admin5.05.59.03.02.12.62.02.42.42.42.32.42.42.22.32.12.32.1
Time in open arm after self-admin1.71.94.62.11.01.40.41.41.61.61.11.71.71.11.11.21.11.2
Bone: periosteal estimation0.00.00.1-0.10.10.10.30.0-0.0-0.00.1-0.0-0.00.10.10.10.10.2
Bone: periosteal perimeter1.22.02.3-1.2-1.5-1.5-1.2-1.4-1.5-1.5-1.4-1.5-1.5-1.4-1.4-1.4-1.4-1.4
Bone: post-yield work0.00.00.20.1-0.1-0.1-0.4-0.2-0.1-0.1-0.2-0.1-0.1-0.3-0.2-0.2-0.3-0.2
Progressive ratio test 1 active lever presses3.13.94.5-1.0-2.0-2.1-1.8-2.1-2.1-2.1-2.0-2.1-2.1-2.0-2.1-1.8-2.0-1.9
Progressive ratio test 1 breakpoint3.23.94.7-1.2-2.0-2.2-1.8-2.1-2.1-2.1-2.0-2.1-2.1-2.0-2.1-1.8-2.0-1.9
Progressive ratio test 1 inactive lever presses1.21.72.2-1.4-1.5-1.2-1.1-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.2
Progressive ratio test 2 active lever presses6.07.08.4-1.8-2.9-2.9-2.6-2.7-2.7-2.7-2.7-2.7-2.7-2.7-2.7-2.7-2.6-2.7
Progressive ratio test 2 breakpoint6.47.38.8-1.9-3.0-2.9-2.6-2.8-2.7-2.7-2.7-2.7-2.7-2.7-2.7-2.8-2.7-2.7
Progressive ratio test 2 inactive lever presses3.15.06.2-2.4-2.5-2.1-2.0-2.2-2.2-2.2-2.1-2.2-2.3-2.1-2.1-2.3-2.1-2.3
Incentive Sensitization - Responses3.65.17.0-1.4-2.6-2.6-2.3-2.3-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.5-2.2-2.3
Incentive Sensitization - Breakpoint3.74.96.6-1.2-2.6-2.5-2.3-2.2-2.2-2.2-2.2-2.1-2.1-2.2-2.2-2.5-2.1-2.3
Sum of active levers in priming session hrs 5-61.51.42.5-0.70.81.31.61.21.01.11.31.01.01.41.31.01.31.1
Progressive ratio0.50.83.9-2.0-0.9-0.3-0.5-0.8-0.9-0.8-0.7-0.9-0.9-0.6-0.6-1.0-0.7-0.9
Food seeking constrained by brief footshock0.70.81.1-0.5-1.0-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-1.0-1.0-0.9
Seeking ratio, punishment vs. effort0.20.32.71.60.30.0-0.10.30.40.40.20.50.50.10.20.40.20.3
Retroperitoneal fat weight11.147.450.3-5.5-7.0-6.5-6.9-7.1-7.1-7.0-7.0-7.0-7.0-7.0-7.0-6.9-7.1-7.0
Reaction time number correct0.00.10.20.20.4-0.00.30.00.10.00.10.00.00.00.00.5-0.00.4
Reaction time mean minus median0.10.20.9-1.0-0.8-0.2-0.3-0.4-0.5-0.4-0.3-0.4-0.5-0.3-0.3-0.6-0.2-0.4
Reaction time mean minus median AUC0.10.30.9-1.0-0.8-0.2-0.3-0.5-0.5-0.5-0.4-0.5-0.5-0.4-0.4-0.6-0.3-0.5
Reaction time num false alarms1.52.22.81.21.51.71.31.51.51.51.41.51.51.41.51.61.31.7
Reaction time num false alarms AUC2.03.13.91.31.91.91.71.81.81.81.71.81.81.71.81.91.62.0
Reaction time trials correct on left0.00.10.20.20.4-0.00.30.00.10.00.10.00.00.00.00.5-0.00.4
Reaction time trials on left0.00.10.30.30.50.10.40.10.20.10.20.10.10.10.10.60.10.5
Reaction time mean0.30.51.6-1.3-0.8-0.8-0.3-0.6-0.7-0.7-0.5-0.8-0.8-0.5-0.6-0.8-0.5-0.6
Reaction time mean AUC0.50.82.3-1.5-0.9-0.9-0.5-0.9-1.0-1.0-0.7-1.0-1.0-0.7-0.8-0.9-0.7-0.8
Median of all reaction times0.50.71.9-1.4-0.8-1.0-0.4-0.8-0.9-0.9-0.6-0.9-0.9-0.6-0.7-0.8-0.6-0.7
Reaction time omissions0.81.21.70.21.01.11.31.21.11.11.31.11.11.31.30.91.31.0
Reaction time false alarm rate2.43.24.01.31.72.01.61.91.91.91.81.91.91.81.91.81.71.8
Reaction time premature initiation rate0.20.20.8-0.90.60.10.80.40.30.30.40.20.20.40.40.50.40.5
Reaction time premature initiations0.20.30.8-0.60.80.20.90.40.30.30.50.20.20.50.40.70.40.7
Std. dev. reaction times0.10.21.3-1.1-0.4-0.2-0.0-0.3-0.4-0.3-0.2-0.4-0.4-0.1-0.2-0.4-0.1-0.2
Reaction time trials completed0.00.10.30.30.50.10.40.10.20.10.20.10.10.10.10.60.10.5
Reaction time trials AUC0.00.00.10.10.3-0.10.2-0.1-0.0-0.1-0.0-0.1-0.1-0.0-0.10.4-0.10.3
Run reversals in cocaine runway, females0.30.31.5-1.2-0.5-0.5-0.0-0.4-0.5-0.5-0.3-0.6-0.6-0.3-0.3-0.6-0.3-0.4
Run reversals in cocaine runway, males4.34.45.41.32.12.12.32.12.02.12.32.02.02.32.32.02.22.0
Latency to leave start box in cocaine runway0.30.41.30.10.31.10.30.60.70.70.60.80.80.60.60.20.70.5
Latency to leave start box in cocaine runway, F0.10.10.6-0.3-0.20.8-0.10.20.30.30.20.40.40.20.2-0.10.30.2
Latency to leave start box in cocaine runway, M0.30.30.40.20.50.60.60.60.60.60.60.60.60.60.60.30.60.4
Std. dev. time between licks in bursts0.20.30.9-0.61.00.70.60.50.40.40.50.40.40.50.50.70.50.7
Total sessions with >9 infusions2.02.43.5-0.5-1.7-1.9-1.5-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.7-1.5-1.5-1.4
Short access day 1 total inactive lever presses0.91.21.5-0.5-1.2-1.0-1.2-1.1-1.1-1.1-1.2-1.1-1.1-1.2-1.2-1.1-1.1-1.0
Short access day 10 total inactive lever presses0.30.78.3-2.9-0.50.4-0.2-0.3-0.4-0.3-0.2-0.4-0.4-0.1-0.2-0.6-0.3-0.4
Short access day 1 total infusions3.34.45.9-1.1-2.1-2.4-1.8-2.2-2.2-2.2-2.1-2.3-2.3-2.1-2.2-2.1-2.1-1.8
Short access day 10 total infusions2.83.64.9-0.3-2.1-2.2-2.2-1.9-1.8-1.9-2.0-1.8-1.8-2.1-2.0-1.9-1.9-1.8
Short access total infusions3.44.35.8-0.8-2.2-2.4-2.0-2.1-2.1-2.1-2.1-2.1-2.2-2.1-2.2-2.1-2.1-1.8
Short access day 1 locomotion2.43.04.1-0.8-1.8-2.0-2.0-1.7-1.6-1.7-1.8-1.6-1.6-1.9-1.9-1.8-1.8-1.5
Short access day 10 total locomotion2.24.16.0-2.4-2.5-1.8-2.2-2.0-1.9-1.9-2.0-1.8-1.8-2.0-2.0-2.3-1.9-1.8
Short access total locomotion3.03.64.7-1.5-2.2-2.0-2.2-1.9-1.8-1.8-1.9-1.7-1.7-1.9-1.9-2.1-1.9-1.7
One hour access (0.3 mA shock)4.75.48.3-2.1-2.9-2.5-2.4-2.3-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.7-2.2-2.4
Compulsive drug intake3.94.65.41.01.92.32.12.32.32.32.32.32.32.32.31.82.32.1
One hour access (shock baseline)6.610.111.4-2.2-3.4-3.4-3.2-3.2-3.2-3.2-3.2-3.2-3.2-3.2-3.2-3.2-3.2-3.2
Social response proportion4.14.65.90.82.32.22.42.22.12.12.32.12.12.32.22.32.32.2
Social responses0.20.33.0-1.7-0.3-0.10.1-0.2-0.3-0.3-0.1-0.4-0.4-0.1-0.3-0.2-0.1-0.2
Social time1.92.63.61.61.91.41.41.61.71.71.61.71.71.51.61.61.51.6
Soleus weight1.44.14.61.91.82.01.92.12.12.12.12.12.12.12.11.92.11.9
Bone: stiffness0.81.34.7-2.2-1.1-0.8-0.9-1.1-1.1-1.1-1.0-1.1-1.1-1.0-1.0-1.2-1.0-1.1
Tibialis anterior weight2.79.311.02.53.32.93.23.03.03.03.12.92.93.13.13.33.13.3
Time to tail flick, vehicle, before self-admin2.22.34.0-1.6-2.0-1.2-1.7-1.4-1.4-1.4-1.5-1.3-1.3-1.5-1.4-1.7-1.4-1.7
Time to tail flick, vehicle, after self-admin4.05.36.7-0.7-2.2-2.6-2.5-2.4-2.3-2.3-2.4-2.3-2.3-2.5-2.5-2.3-2.3-2.2
Time to tail flick, test, before self-admin2.02.12.7-0.7-1.2-1.0-1.6-1.5-1.5-1.5-1.6-1.5-1.5-1.6-1.6-1.4-1.4-1.7
Time to tail flick, test, after self-admin4.74.97.2-0.9-2.0-1.9-2.7-2.4-2.2-2.2-2.5-2.2-2.1-2.5-2.4-2.0-2.5-2.1
Delta time to tail flick, vehicle, before/after SA0.20.20.80.90.1-0.7-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.5-0.2-0.4-0.2
Delta time to tail flick, test, before/after SA0.20.20.70.8-0.3-0.6-0.7-0.3-0.2-0.2-0.4-0.1-0.1-0.4-0.4-0.1-0.5-0.1
Tibia length0.20.62.0-0.31.00.71.40.60.50.40.80.30.30.80.80.90.81.0
Ambulatory time before self-admin0.10.10.30.00.10.30.40.20.20.20.30.10.10.30.30.30.30.6
Ambulatory time after self-admin0.60.75.5-2.3-0.2-0.80.3-0.6-0.8-0.8-0.4-0.9-0.9-0.3-0.5-0.2-0.5-0.2
Bone: tissue strength0.00.00.3-0.2-0.10.5-0.20.20.20.20.10.30.30.10.2-0.10.1-0.0
Total heroin consumption1.01.22.3-0.00.91.01.51.11.01.01.31.00.91.31.11.11.31.3
Bone: trabecular number0.50.81.20.2-0.8-0.9-1.1-0.9-0.9-0.9-1.0-0.8-0.8-1.0-1.0-1.0-1.0-1.0
Bone: trabecular spacing0.20.21.3-1.2-0.5-0.4-0.2-0.4-0.4-0.4-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.4
Bone: trabecular thickness0.50.60.7-0.5-0.8-0.6-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.8-0.8
Bone: trabecular tissue density0.81.22.1-0.50.81.41.11.21.11.11.21.11.11.21.20.61.20.7
Water consumed over 24 hours0.50.71.1-1.0-0.7-0.8-0.6-0.9-0.9-0.9-0.8-0.9-0.9-0.8-0.9-0.6-0.8-0.6
Number of responses in last shaping day3.74.04.7-2.2-2.0-2.1-1.7-2.0-2.1-2.1-1.9-2.1-2.1-1.9-2.0-1.9-1.9-1.9