Hub : Genes

Mvb12a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Mvb12a	0.3	0.16	3.0e-03	0.07	0.04	0.08	0.07	7.5e-03	3.5e-02	7.3e-03	7.7e-03
2	LHb	alternative TSS	XM_063275152.1	0.28	0.16	7.8e-03	0.02	0.08	0.02	0.02	1.2e-01	6.5e-03	9.0e-02	9.0e-02
3	BLA	mRNA stability	Mvb12a	0.08	0.06	9.8e-04	0.05	0.05	0.05	0.04	7.9e-04	1.5e-03	1.9e-03	3.6e-03
4	NAcc	mRNA stability	Mvb12a	0.05	0.04	1.8e-05	0.03	0.03	0.03	0.02	8.1e-05	1.8e-05	5.2e-05	3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.1	5.1	-2.3	1.7	0.3	-0.4
Area under the delay curve	0.8	0.9	1.6	1.2	-0.7	-1.1	0.7
BMI with tail	1.3	4.6	8.9	-3.0	3.0	0.7	0.2
BMI without tail	1.5	4.7	11.3	-2.4	3.4	-0.4	1.3
Body weight	3.7	16.2	35.4	-5.3	5.9	0.6	0.9
Weight adjusted by age	1.0	1.6	3.9	-1.4	2.0	0.0	0.7
Bone surface	1.1	2.0	4.5	-2.1	1.3	0.9	-1.0
Bone volume	1.3	2.3	5.3	-2.3	1.9	0.5	-0.4
Breakpoint value in progressive ratio session	0.7	0.8	1.2	-1.0	0.4	1.0	-1.1
Number of licking bursts	0.1	0.1	0.3	0.5	-0.4	-0.2	0.1
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.3	-0.3	0.1
Locomotion velocity, session 1	3.9	4.2	6.4	-2.1	0.6	2.5	-2.3
Locomotion distance, session 1	3.1	3.9	6.7	-1.4	-0.6	2.5	-2.6
Locomotion velocity, session 2	1.2	1.5	3.0	-1.6	1.7	0.3	0.0
Locomotion distance, session 2	2.6	3.7	6.5	-1.2	-0.9	2.4	-2.5
Locomotion velocity, session 3	0.1	0.1	0.4	-0.3	-0.2	0.3	-0.6
Locomotion distance, session 3	0.8	0.8	1.5	-0.8	-0.3	1.1	-1.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.4	-0.5	-0.2	0.3	-0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.2
Locomotion velocity, session 7	0.7	0.8	1.6	0.9	-1.3	0.7	-0.6
Locomotion distance, session 7	1.1	1.4	3.3	1.5	-1.8	0.1	-0.4
Stereotopy head waving bouts, day 7	1.6	1.8	4.1	-2.0	1.3	0.9	-0.9
Stereotopy head waving duration, day 7	1.4	1.7	3.8	-2.0	1.7	0.4	-0.3
Locomotion velocity, session 8	1.8	2.2	3.9	-1.2	-0.2	2.0	-1.8
Locomotion distance, session 8	1.7	2.5	3.9	-1.5	-0.1	2.0	-1.9
Degree of sensitization distance	1.3	1.3	3.0	1.7	-1.2	-0.8	0.6
Degree of sensitization stereotypy	1.9	2.1	4.5	-2.1	1.5	1.1	-0.8
Conditioned locomotion	0.1	0.1	0.2	0.5	-0.3	-0.2	0.1
Cocaine response after cond. corrected	3.0	3.6	5.2	2.2	-0.7	-2.3	1.9
Cocaine response after cond. not corrected	1.9	2.2	3.8	1.9	-1.0	-1.6	1.2
Cocaine response before conditioning	1.6	1.9	3.3	-0.8	-0.5	1.8	-1.8
Saline control response	1.1	1.5	2.5	-1.6	0.4	1.3	-1.3
Bone: connectivity density	0.7	1.1	2.5	-1.6	1.1	0.5	-0.6
Bone: cortical apparent density	0.0	0.0	0.1	0.1	-0.3	0.0	-0.2
Bone: cortical area	4.3	6.6	15.0	-3.2	3.9	0.1	0.9
Bone: cortical porosity	1.3	1.5	3.2	-0.9	0.1	1.8	-1.3
Bone: cortical porosity	1.5	1.6	3.4	-1.0	0.2	1.8	-1.4
Bone: cortical thickness	4.1	6.7	13.3	-3.6	3.6	0.7	0.2
Bone: cortical thickness	2.0	2.4	4.8	-2.1	2.2	0.2	0.3
Bone: cortical tissue density	0.1	0.1	0.2	0.3	-0.5	0.0	-0.3
Condit. Reinf. active minus inactive responses	1.4	1.6	3.2	-1.8	1.3	1.1	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.7	0.7	0.0	0.1
Condit. Reinf. active responses	1.8	2.3	4.4	-2.1	1.5	1.3	-0.8
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.8	0.8	0.6	-0.2
Incentive salience index mean	4.0	4.9	9.6	-3.1	2.0	2.0	-1.5
Condit. Reinf. lever presses	6.3	8.9	17.2	-4.1	2.4	2.8	-2.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.8	-0.0	0.9	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	-0.8	0.8	0.2	0.0
Condit. Reinf. active responses	0.6	0.9	1.6	-0.1	-0.9	1.1	-1.2
Condit. Reinf. inactive responses	1.3	1.7	4.2	1.4	-2.0	0.4	-0.8
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	0.2	-0.3	0.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.1	-0.6	0.4	-0.5
Conditioned reinforcement - actives	0.5	0.9	1.7	-0.1	1.1	-0.8	1.3
Conditioned reinforcement - inactives	3.1	4.5	8.5	-0.8	2.9	-1.5	2.6
Conditioned locomotion	1.4	1.8	3.6	0.5	0.9	-1.6	1.9
Patch foraging indifference point 0 sec	1.2	2.3	5.7	-1.4	2.4	-0.5	1.0
Patch foraging indifference point AUC	0.3	0.4	1.0	0.6	-0.3	-1.0	0.3
Delay disc. indifference point, 0s delay	1.1	1.2	3.2	1.2	-1.8	0.1	-0.6
Delay disc. indifference point, 16s delay	3.2	3.5	6.5	2.6	-1.8	-1.8	1.0
Delay disc. indifference point, 2s delay	0.4	0.4	0.9	0.0	-0.5	0.7	-0.9
Delay disc. indifference point, 24s delay	0.6	0.7	1.1	0.8	-0.1	-1.0	1.1
Delay disc. indifference point, 4s delay	0.2	0.3	0.4	-0.7	0.2	0.6	-0.5
Delay disc. indifference point, 8s delay	1.9	2.2	4.1	1.6	-0.4	-2.0	1.5
Indifference point function ln k	0.2	0.3	0.6	-0.6	0.8	0.5	0.4
Indifference point function log k	0.2	0.3	0.6	-0.6	0.8	0.5	0.4
Patch foraging total patch changes 0 sec	1.7	3.3	8.0	-1.6	2.8	-0.8	1.4
Patch foraging total patch changes 12 sec	0.7	0.9	1.5	-0.2	1.0	-1.2	1.0
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	0.6	-0.3	-0.8	0.2
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	-0.6	0.8	-0.3	0.2
Patch foraging total patch changes 6 sec	1.0	1.5	3.4	-1.2	1.8	-0.8	0.8
Patch foraging time to switch 0 sec	0.4	0.9	1.5	0.1	-1.2	0.8	-1.2
Patch foraging water rate 0 sec	0.6	1.3	3.2	-1.3	1.8	0.3	0.5
Patch foraging water rate 12 sec	0.2	0.4	0.7	-0.7	0.8	0.6	0.2
Patch foraging water rate 18 sec	0.8	1.3	3.0	-0.7	-0.0	1.7	-1.2
Patch foraging water rate 24 sec	1.9	2.7	4.4	-2.0	1.2	2.1	-1.1
Patch foraging water rate 6 sec	0.4	0.6	1.3	-0.3	1.2	-0.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.0	-0.4	-0.7	1.0	-0.6
Distance traveled before self-admin	0.6	0.8	1.9	-1.1	1.4	0.3	0.2
Distance traveled after self-admin	1.5	1.8	3.5	-1.9	1.8	0.8	-0.2
Extensor digitorum longus weight	0.5	1.9	4.2	-2.0	1.8	0.1	0.1
Bone: elastic displacement	1.0	1.2	2.2	-1.0	0.1	1.5	-1.3
Bone: elastic work	1.2	1.6	3.8	-1.5	2.0	0.1	0.5
Bone: endosteal estimation	0.5	1.2	2.0	1.4	-0.3	-1.2	1.1
Bone: endosteal perimeter	0.4	0.8	1.6	0.2	1.0	-0.8	1.3
Epididymis fat weight	0.5	1.8	3.7	-1.7	1.9	0.7	0.1
Delta time in closed arm before/after self-admin	1.1	1.1	1.6	1.2	-0.2	-1.3	1.0
Delta time in open arm before/after self-admin	0.4	0.4	0.7	0.0	-0.7	0.5	-0.8
Diff in mean of infusions in LGA sessions	0.4	0.5	1.4	-0.3	1.2	-0.3	0.7
Delay discount exponential model param	0.5	0.6	1.0	-0.9	0.3	1.0	-0.7
Extinction: sum of active levers before priming	1.6	1.8	2.9	-1.1	-0.2	1.7	-1.7
Active lever presses in extinction session 6	0.1	0.1	0.1	0.1	-0.3	0.3	-0.2
Bone: final force	3.9	6.2	14.8	-2.3	3.9	-1.0	1.9
Bone: final moment	3.4	5.5	12.7	-1.9	3.6	-1.2	2.1
Food consumed during 24 hour testing period	1.3	1.8	3.0	-1.4	-0.0	1.5	-1.7
Glucose	0.6	0.9	2.6	-0.9	1.6	-0.1	0.6
Heart weight	2.1	3.2	6.8	-2.6	2.3	0.8	-0.3
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.6	0.1	0.7	-0.4
Intermittent access intake day 1-15 change	0.2	0.3	0.6	-0.8	0.6	0.5	-0.3
Intermittent access intake escalation	0.2	0.3	0.5	-0.7	0.3	0.6	-0.5
Intermittent access intake escalation 2	0.2	0.2	0.5	-0.7	0.7	0.0	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	-0.3	0.6	-0.1	0.4
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.2	-0.1	0.2	-0.0
Intermitt. access escalation Index	0.4	0.5	1.2	0.9	-1.1	-0.3	-0.0
Intermittent access day 1 total infusions	1.2	2.0	3.2	1.4	0.3	-1.7	1.8
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.4	0.2	-0.5	0.6
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.7	0.8	-0.0	-0.8	0.8
Intermittent access total infusions	1.3	1.5	2.5	0.9	0.6	-1.5	1.6
Intermittent access day 1 locomotion	1.2	1.6	2.9	0.6	1.0	-1.4	1.7
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.3	0.2	-0.4	0.4
Intermittent access total locomotion	1.1	1.3	2.2	0.3	1.2	-1.3	1.5
Intermittent access standard deviation	0.1	0.2	0.5	0.2	0.3	-0.5	0.7
Left kidney weight	0.6	2.7	5.6	-2.4	2.2	0.6	-0.2
Right kidney weight	1.0	4.5	9.6	-2.9	3.1	0.5	0.1
Cocaine induced anxiety	0.6	0.8	1.9	-0.4	1.4	-0.6	1.0
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.2	-0.2	0.1
Baseline Anxiety	1.3	1.5	3.2	0.5	-1.8	0.8	-1.3
Tail length	0.6	2.3	5.5	-1.7	2.4	-0.1	0.7
Length with tail	1.5	6.7	15.2	-3.3	3.9	0.3	0.5
Length without tail	1.5	4.8	9.5	-3.1	3.1	0.5	0.1
Times rat made contact with spout	0.2	0.2	0.4	0.0	-0.5	0.4	-0.6
Lifetime Intake	1.4	1.7	3.1	0.5	1.1	-1.5	1.8
Liver weight, left	1.2	1.9	3.0	-1.4	-0.0	1.7	-1.7
Liver weight, right	0.8	1.4	3.0	-1.6	1.7	0.3	0.3
Locomotor activity	3.4	5.3	8.1	-2.8	1.2	2.7	-2.1
Locomotor testing distance	1.2	2.1	3.1	-1.6	0.2	1.8	-1.6
Locomotor testing rearing	1.2	2.5	3.9	-1.6	0.1	1.9	-2.0
Locomotion in novel chamber	0.4	0.6	1.0	-1.0	0.6	0.8	-0.5
Locomotion in novel chamber post-restriction	1.8	2.9	4.0	-2.0	0.8	2.0	-1.7
Fecal boli incidents, locomotor time 1	0.5	0.7	1.4	1.2	-0.9	-0.6	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.8	-0.7	-0.0	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.9	0.9	-0.5	-0.6	0.6
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.1	-0.7	0.3	-0.8
Total resting periods, locomotor time 1	0.5	0.6	1.2	0.4	-1.1	0.4	-1.0
Rest time, locomotor task time 1	0.4	0.5	0.9	1.0	-0.6	-0.7	0.6
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.3	-0.1	-0.1	0.0
Vertical activity count, locomotor time 1	0.3	0.8	1.2	-1.1	0.5	1.0	-0.8
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.7	1.1	-1.3	0.1	0.2
Bouts of movement, locomotor time 2	0.5	0.7	1.0	-1.0	0.3	1.0	-1.0
Total resting periods, locomotor time 2	0.3	0.5	0.7	-0.8	0.3	0.7	-0.8
Rest time, locomotor task time 2	0.2	0.3	0.6	-0.4	0.8	-0.4	0.4
Distance moved, locomotor task time 2	0.5	0.6	1.2	1.1	-0.8	-0.4	0.5
Vertical activity count, locomotor time 2	0.0	0.1	0.2	-0.2	0.2	0.4	0.1
Light reinforcement 1	0.3	0.7	1.2	1.1	-0.3	-0.8	0.8
Light reinforcement 2	2.8	4.4	7.0	2.3	-0.5	-2.7	2.2
Bone: marrow area	0.5	1.1	1.9	1.4	-0.4	-1.1	1.0
Bone: maximum diameter	1.3	2.4	6.1	-1.4	2.5	-0.5	1.2
Bone: maximum force	4.2	7.4	17.6	-3.3	4.2	0.1	1.0
Bone: maximum moment	3.3	5.7	14.0	-2.7	3.7	-0.2	1.2
Mean time between licks in bursts	0.7	1.8	4.5	-1.3	2.1	-0.2	1.0
Mean num. licks in bursts	0.1	0.2	0.4	-0.6	0.2	0.4	-0.4
Cd content in liver	1.0	1.1	2.3	0.2	0.9	-1.2	1.5
Co content in liver	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1
Cu content in liver	3.0	3.6	6.6	-1.3	-0.5	2.6	-2.4
Fe content in liver	0.4	0.5	1.4	0.9	-1.2	-0.1	-0.2
K content in liver	1.5	1.4	3.1	1.6	-1.8	0.2	-0.4
Mg content in liver	0.1	0.1	0.2	0.4	-0.3	0.2	-0.1
Mn content in liver	0.2	0.2	0.5	-0.4	0.4	0.7	-0.4
Na content in liver	2.0	2.1	3.4	0.0	-1.5	1.7	-1.8
Rb content in liver	2.3	2.7	4.8	0.9	0.8	-2.1	2.2
Se content in liver	0.6	0.7	1.3	-0.6	-0.1	1.2	-1.0
Sr content in liver	0.3	0.2	0.5	0.6	-0.7	0.1	-0.2
Zn content in liver	0.2	0.3	0.7	-0.2	-0.1	0.8	-0.6
Bone: minimum diameter	1.0	1.8	4.3	-1.5	2.1	-0.2	0.8
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	0.3	-0.1	0.1
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	0.0	0.0	0.1
Total zone transitions, hab. session 1	0.8	1.1	2.0	-0.5	-0.5	1.4	-1.4
Total locomotion distance, hab. session 1	2.0	2.9	5.2	-0.7	-0.9	2.3	-2.3
Locomotion velocity, hab. session 1	2.0	2.8	5.0	-0.6	-1.0	2.2	-2.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	0.1	-0.3	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	-0.2	-0.3	0.4
Total zone transitions, hab. session 2	0.2	0.3	0.5	-0.2	-0.3	0.7	-0.7
Total locomotion distance, hab. session 2	1.7	2.2	3.8	-1.4	0.1	2.0	-1.7
Locomotion velocity, hab. session 2	1.8	2.4	4.3	-1.4	0.0	2.1	-1.9
Novel to familiar place preference ratio	1.1	1.2	1.8	1.2	-0.3	-1.3	1.2
Novelty place preference	1.1	1.2	1.8	1.4	-0.4	-1.2	1.1
Time in novel zone, NPP test	1.0	1.1	2.0	1.4	-0.7	-1.0	0.9
Total zone transitions, NPP test	1.1	1.6	3.0	-0.7	-0.6	1.7	-1.7
Total locomotion distance, NPP test	2.8	3.8	6.7	-1.2	-0.7	2.6	-2.6
Locomotion velocity, NPP test	2.2	3.1	5.6	-0.9	-0.8	2.4	-2.4
Intraocular pressure	1.1	1.5	2.7	-0.0	1.2	-1.4	1.6
Delta distance traveled before/after self-admin	0.6	0.6	1.1	-1.0	1.0	0.4	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.6	0.5	0.3	-0.1
Parametrial fat weight	2.3	5.5	10.2	0.7	1.8	-2.8	3.2
Pavlov. Cond. lever latency	4.7	5.9	12.0	3.5	-1.6	-2.2	2.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	-0.9	0.6	-0.1	0.1
Pavlov. Cond. change in total contacts	2.7	2.9	6.9	-2.6	2.0	0.7	-0.4
Pavlov. Cond. index score	1.9	2.4	5.2	-2.3	0.9	1.4	-1.3
Pavlov. Cond. latency score	2.9	3.6	7.4	-2.7	1.0	1.8	-1.7
Pavlov. Cond. lever contacts	3.8	4.5	9.7	-3.1	1.5	1.8	-1.7
Pavlov. Cond. magazine entry number	0.4	0.4	1.2	1.1	-0.8	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.0	-1.4	0.6	1.4	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	4.2	-2.0	0.8	1.2	-1.1
Pavlov. Cond. response bias	1.0	1.2	3.1	-1.8	1.0	0.7	-0.6
Pavlov. Cond. lever latency	0.6	0.8	1.6	0.9	-1.3	0.5	-0.6
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	-1.0	1.1	-0.9	0.5
Pavlov. Cond. change in total contacts	0.6	0.9	2.0	-1.2	1.4	-0.4	0.5
Pavlov. Cond. index score	0.9	1.2	2.4	-1.1	1.5	-0.9	0.8
Pavlov. Cond. latency score	0.7	0.9	1.6	-1.1	1.3	-0.8	0.5
Pavlov. Cond. lever contacts	0.5	0.7	1.5	-1.0	1.2	-0.5	0.4
Pavlov. Cond. magazine entry number	1.3	1.5	3.0	1.2	-1.7	1.0	-0.9
Pavlov. Cond. intertrial magazine entries	0.8	1.3	2.2	1.0	-1.5	1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.4	2.7	-1.2	1.6	-0.9	0.8
Pavlov. Cond. response bias	0.7	0.9	2.0	-1.0	1.4	-0.6	0.6
Time in closed arm before self-admin	3.0	3.8	9.1	-1.9	3.0	-0.5	1.6
Time in closed arm after self-admin	3.9	4.1	8.2	0.5	1.8	-2.2	2.9
Time in open arm before self-admin	2.2	2.5	4.3	-1.2	-0.3	2.0	-2.1
Time in open arm after self-admin	5.9	6.4	10.2	-2.3	-0.3	3.2	-3.2
Bone: periosteal estimation	0.8	1.6	3.9	-1.0	2.0	-0.6	1.1
Bone: periosteal perimeter	2.2	3.8	8.9	-1.7	3.0	-0.9	1.6
Bone: post-yield work	0.1	0.2	0.5	-0.1	-0.1	0.7	-0.5
Progressive ratio test 1 active lever presses	1.1	1.4	3.5	-0.7	1.9	-0.6	1.1
Progressive ratio test 1 breakpoint	1.0	1.2	3.1	-0.7	1.8	-0.5	1.0
Progressive ratio test 1 inactive lever presses	0.6	0.9	2.2	-0.9	1.5	0.1	0.7
Progressive ratio test 2 active lever presses	0.9	1.1	1.8	0.8	0.5	-1.3	1.3
Progressive ratio test 2 breakpoint	0.8	0.9	1.5	0.8	0.3	-1.2	1.2
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.3	-0.3	1.1	-0.5	0.9
Incentive Sensitization - Responses	1.9	2.7	4.7	2.2	-1.0	-1.8	1.3
Incentive Sensitization - Breakpoint	2.2	2.9	5.3	2.3	-1.3	-1.8	1.2
Sum of active levers in priming session hrs 5-6	2.0	1.8	3.0	0.4	-1.7	1.1	-1.7
Progressive ratio	0.2	0.3	0.5	0.7	-0.5	-0.7	0.4
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	-0.6	-0.2	-0.2
Seeking ratio, punishment vs. effort	0.5	0.7	1.2	-0.6	-0.1	1.1	-1.1
Retroperitoneal fat weight	1.2	5.2	10.8	-1.4	3.3	-1.3	2.5
Reaction time number correct	2.3	4.4	8.0	-2.1	0.4	2.8	-2.2
Reaction time mean minus median	0.0	0.1	0.2	-0.3	0.0	0.0	-0.4
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	0.2	0.0	-0.3
Reaction time num false alarms	0.4	0.6	1.3	-0.3	1.1	-0.8	0.7
Reaction time num false alarms AUC	0.3	0.5	0.8	-0.1	0.9	-0.7	0.7
Reaction time trials correct on left	2.3	4.4	8.0	-2.1	0.4	2.8	-2.2
Reaction time trials on left	2.3	4.4	7.9	-2.2	0.5	2.8	-2.2
Reaction time mean	1.6	2.6	5.0	1.2	0.3	-2.2	2.0
Reaction time mean AUC	1.4	2.3	4.2	1.5	-0.2	-2.0	1.6
Median of all reaction times	2.9	4.1	7.3	1.8	0.1	-2.7	2.5
Reaction time omissions	0.5	0.7	1.9	-0.6	1.4	-0.5	0.5
Reaction time false alarm rate	1.2	1.6	3.1	0.6	0.9	-1.8	1.5
Reaction time premature initiation rate	1.3	1.8	2.8	-1.4	0.2	1.6	-1.7
Reaction time premature initiations	2.6	4.7	7.1	-2.3	0.5	2.7	-2.4
Std. dev. reaction times	0.2	0.3	0.5	-0.3	0.7	-0.6	0.3
Reaction time trials completed	2.3	4.4	7.9	-2.2	0.5	2.8	-2.2
Reaction time trials AUC	2.0	3.8	6.7	-2.1	0.6	2.6	-1.9
Run reversals in cocaine runway, females	1.4	1.4	3.4	-0.8	1.8	-0.5	1.1
Run reversals in cocaine runway, males	0.8	0.8	1.8	0.0	-1.0	0.8	-1.3
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.0	-0.2	-0.1	0.1
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	-0.8	0.6	0.4	-0.1
Latency to leave start box in cocaine runway, M	1.8	1.7	3.0	1.7	-1.4	-1.1	0.7
Std. dev. time between licks in bursts	0.9	1.2	3.2	-0.9	1.8	-0.4	0.9
Total sessions with >9 infusions	1.8	2.1	4.6	-0.7	2.1	-1.0	1.6
Short access day 1 total inactive lever presses	1.4	1.8	3.8	0.7	0.6	-1.6	1.9
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.1	-0.4	0.2	-0.1
Short access day 1 total infusions	1.4	1.9	4.4	-1.0	2.1	-0.5	1.4
Short access day 10 total infusions	0.3	0.3	0.7	-0.1	0.8	-0.2	0.8
Short access total infusions	0.9	1.2	2.2	0.0	1.3	-1.0	1.5
Short access day 1 locomotion	3.0	3.8	6.8	-0.6	2.6	-1.4	2.4
Short access day 10 total locomotion	1.9	3.4	6.4	-2.5	2.2	1.5	-0.5
Short access total locomotion	1.3	1.6	4.2	-1.1	2.0	-0.3	0.9
One hour access (0.3 mA shock)	0.9	1.1	1.9	0.9	0.2	-1.2	1.4
Compulsive drug intake	1.0	1.2	2.5	1.5	-1.6	-0.5	0.0
One hour access (shock baseline)	1.1	1.7	2.8	-0.1	1.5	-1.3	1.7
Social response proportion	1.9	2.1	4.8	-1.8	2.2	-0.2	0.5
Social responses	1.5	2.0	3.8	-2.0	1.2	1.3	-0.9
Social time	0.4	0.5	0.9	-1.0	0.8	0.7	-0.2
Soleus weight	0.8	2.4	4.4	0.7	1.1	-1.9	2.1
Bone: stiffness	3.2	5.3	12.2	-2.8	3.5	-0.2	1.1
Tibialis anterior weight	0.9	3.1	6.7	-2.6	1.2	1.4	-1.4
Time to tail flick, vehicle, before self-admin	1.0	1.1	2.2	1.5	-0.7	-1.0	0.7
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.3	0.5	-0.3	0.3
Time to tail flick, test, before self-admin	1.2	1.3	2.5	-0.4	1.6	-1.0	1.2
Time to tail flick, test, after self-admin	2.1	2.2	4.4	2.1	-1.5	-1.3	0.7
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.3	-1.1	0.4	0.8	-0.6
Delta time to tail flick, test, before/after SA	1.4	1.4	3.3	1.5	-1.8	-0.1	-0.3
Tibia length	0.6	1.6	3.2	-1.8	1.7	0.0	0.2
Ambulatory time before self-admin	0.8	1.2	2.9	-1.3	1.7	0.3	0.4
Ambulatory time after self-admin	2.7	3.2	5.9	-2.4	2.4	1.1	-0.2
Bone: tissue strength	0.0	0.0	0.1	-0.1	0.3	0.2	0.0
Total heroin consumption	0.0	0.0	0.1	0.1	0.3	-0.2	0.1
Bone: trabecular number	1.3	2.2	5.0	-2.2	1.8	0.4	-0.4
Bone: trabecular spacing	0.4	0.5	1.3	1.2	-0.7	-0.4	0.4
Bone: trabecular thickness	1.4	1.7	3.5	-1.9	1.5	0.9	-0.6
Bone: trabecular tissue density	0.6	0.9	1.9	-0.2	-0.6	1.4	-1.2
Water consumed over 24 hours	0.6	0.9	1.3	-1.2	0.4	0.9	-1.1
Number of responses in last shaping day	0.3	0.3	0.5	-0.7	0.5	0.7	-0.2