Hub : Genes

Mrpl54

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Mrpl54 0.12 0.07 0.0e+00 0.16 0.16 0.15 0.16 7.0e-17 1.8e-17 3.0e-16 1.1e-17
2 OFC mRNA stability Mrpl54 0.29 0.16 9.7e-07 0.27 0.25 0.24 0.25 5.0e-07 1.1e-06 1.6e-06 1.2e-06
3 NAcc mRNA stability Mrpl54 0.12 0.12 1.6e-11 0.09 0.1 0.1 0.1 3.9e-10 1.9e-11 1.0e-11 2.2e-11
4 BLA mRNA stability Mrpl54 0.19 0.11 2.6e-12 0.17 0.22 0.22 0.22 1.2e-09 5.8e-12 5.0e-12 5.8e-12
5 Brain mRNA stability Mrpl54 0.16 0.1 1.3e-15 0.14 0.14 0.14 0.14 1.2e-12 6.3e-13 4.1e-13 7.4e-13
6 pVTA mRNA stability Mrpl54 0.06 0.05 4.2e-03 0.05 0.05 0.05 0.05 4.0e-03 2.4e-03 4.7e-03 3.7e-03
7 IL gene expression Mrpl54 0.3 0.18 1.8e-04 0.13 0.09 0.09 0.1 6.2e-04 3.0e-03 3.0e-03 2.4e-03
8 Adipose mRNA stability Mrpl54 0.02 0.02 8.5e-03 0.01 0.01 0 0.01 7.5e-03 2.5e-02 1.3e-01 2.5e-02
9 Liver gene expression Mrpl54 0.06 0.04 9.2e-08 0.06 0.06 0.06 0.06 3.1e-07 3.0e-07 3.2e-07 3.4e-07
10 Adipose gene expression Mrpl54 0.11 0.06 1.6e-12 0.1 0.1 0.1 0.1 3.7e-11 3.3e-11 3.4e-11 5.2e-11
11 OFC gene expression Mrpl54 0.53 0.19 8.0e-09 0.3 0.35 0.36 0.35 8.1e-08 3.4e-09 2.6e-09 2.9e-09
12 NAcc gene expression Mrpl54 0.33 0.16 0.0e+00 0.22 0.26 0.26 0.26 5.3e-25 7.2e-30 5.8e-30 8.9e-30
13 BLA gene expression Mrpl54 0.5 0.17 0.0e+00 0.2 0.26 0.25 0.26 1.0e-10 3.2e-14 1.6e-13 4.1e-14
14 PL gene expression Mrpl54 0.39 0.18 0.0e+00 0.21 0.28 0.27 0.28 2.7e-22 1.3e-30 7.3e-30 1.9e-31
15 pVTA gene expression Mrpl54 0.44 0.18 5.4e-10 0.19 0.24 0.25 0.24 8.5e-09 6.3e-11 2.6e-11 5.3e-11
16 Brain gene expression Mrpl54 0.42 0.16 0.0e+00 0.21 0.29 0.29 0.29 3.3e-19 5.0e-27 4.8e-27 4.4e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density1.32.17.1-1.21.20.10.10.0-0.1-0.5-0.60.71.1-1.6-1.71.92.6-2.52.7
Area under the delay curve2.02.12.81.2-1.2-1.6-1.6-1.51.5-1.6-1.61.71.7-1.6-1.61.60.5-1.20.7
BMI with tail4.916.025.94.6-4.5-5.1-4.8-4.84.8-4.6-4.64.54.2-3.7-3.53.3-1.0-1.30.1
BMI without tail1.73.57.62.5-2.4-2.8-2.3-2.22.3-2.0-2.01.91.6-1.3-1.01.0-1.60.3-0.6
Body weight0.93.75.52.3-2.3-2.2-2.3-2.32.3-2.2-2.22.12.0-1.7-1.71.5-0.5-0.7-0.2
Weight adjusted by age0.40.41.90.9-0.9-1.0-0.6-0.50.6-0.4-0.40.30.10.00.3-0.2-1.40.9-0.7
Bone surface2.44.215.1-2.22.20.70.80.6-0.7-0.3-0.30.51.1-1.9-1.92.33.9-3.43.8
Bone volume2.54.215.1-2.22.20.70.80.6-0.7-0.3-0.30.51.1-1.9-1.92.33.9-3.43.8
Breakpoint value in progressive ratio session4.75.27.1-2.12.02.52.52.5-2.52.52.6-2.7-2.72.42.6-2.4-0.61.8-0.8
Number of licking bursts0.40.51.90.7-0.8-0.1-0.2-0.30.2-0.00.2-0.2-0.40.50.7-0.8-1.41.2-1.4
Context. condit. distance diff. score0.20.30.50.7-0.7-0.6-0.6-0.70.6-0.7-0.50.50.5-0.5-0.40.3-0.2-0.1-0.1
Locomotion velocity, session 10.70.72.0-1.31.30.80.80.9-0.80.60.5-0.4-0.2-0.1-0.20.31.4-0.91.3
Locomotion distance, session 10.70.93.4-1.01.00.20.30.3-0.3-0.0-0.10.20.5-0.8-0.91.01.8-1.51.8
Locomotion velocity, session 22.63.07.1-2.62.72.02.12.1-2.11.71.6-1.4-1.10.60.5-0.22.1-0.91.8
Locomotion distance, session 21.31.94.6-2.12.11.41.51.4-1.41.01.0-0.8-0.5-0.0-0.10.32.1-1.31.9
Locomotion velocity, session 34.85.67.8-2.62.52.72.72.8-2.82.82.7-2.7-2.62.32.3-2.20.21.2-0.3
Locomotion distance, session 30.00.00.1-0.00.00.0-0.00.1-0.00.20.1-0.1-0.10.30.2-0.2-0.20.3-0.2
Stereotopy head waving bouts, day 33.33.96.3-2.52.52.42.42.4-2.42.22.2-2.2-2.01.51.5-1.41.00.30.6
Stereotopy head waving duration, day 34.04.87.1-2.62.62.62.72.6-2.72.52.5-2.4-2.31.91.8-1.70.70.60.3
Locomotion velocity, session 70.60.61.2-1.11.11.01.01.0-1.00.90.8-0.8-0.70.50.5-0.40.6-0.10.4
Locomotion distance, session 70.20.20.80.5-0.5-0.2-0.3-0.20.2-0.0-0.1-0.0-0.10.40.3-0.4-0.90.8-0.9
Stereotopy head waving bouts, day 70.50.62.0-0.50.50.10.10.0-0.1-0.3-0.30.40.6-0.8-0.80.91.4-1.31.4
Stereotopy head waving duration, day 70.60.72.7-0.90.90.50.50.4-0.50.00.10.00.2-0.7-0.60.71.7-1.41.6
Locomotion velocity, session 80.91.14.1-1.41.40.70.80.7-0.70.20.3-0.10.1-0.6-0.60.82.0-1.61.9
Locomotion distance, session 80.10.10.5-0.50.60.30.30.3-0.30.20.2-0.1-0.0-0.1-0.10.20.7-0.50.6
Degree of sensitization distance0.30.30.50.6-0.6-0.6-0.6-0.70.6-0.7-0.60.60.6-0.6-0.50.5-0.0-0.30.1
Degree of sensitization stereotypy2.02.23.40.9-0.9-1.3-1.4-1.41.4-1.6-1.61.71.8-1.8-1.81.81.0-1.61.2
Conditioned locomotion1.41.63.82.0-2.0-1.5-1.5-1.51.5-1.1-1.11.00.7-0.3-0.20.0-1.60.8-1.4
Cocaine response after cond. corrected3.64.18.62.9-2.9-2.5-2.6-2.52.5-2.1-2.01.91.6-1.1-1.00.8-1.70.4-1.3
Cocaine response after cond. not corrected3.94.39.43.0-3.1-2.6-2.6-2.52.6-2.1-2.12.01.6-1.1-1.00.7-1.90.5-1.5
Cocaine response before conditioning0.30.40.9-0.90.90.70.80.8-0.80.70.6-0.6-0.50.40.3-0.20.6-0.10.4
Saline control response0.10.10.20.4-0.4-0.3-0.3-0.30.3-0.1-0.20.10.10.10.1-0.1-0.50.3-0.4
Bone: connectivity density1.01.64.3-0.50.6-0.4-0.4-0.40.4-0.8-1.01.01.3-1.6-1.71.82.0-2.12.1
Bone: cortical apparent density0.81.01.91.2-1.3-1.1-1.1-1.31.1-1.4-1.01.01.0-1.1-0.80.8-0.2-0.5-0.0
Bone: cortical area1.01.63.20.2-0.2-0.8-0.7-0.90.8-1.3-1.11.21.4-1.7-1.61.71.4-1.81.6
Bone: cortical porosity0.40.41.0-1.01.00.80.80.8-0.80.60.6-0.6-0.40.20.2-0.10.8-0.30.6
Bone: cortical porosity0.30.41.3-0.60.60.20.20.1-0.2-0.2-0.10.20.4-0.6-0.60.71.2-1.01.1
Bone: cortical thickness1.11.82.71.0-1.0-1.3-1.3-1.51.4-1.6-1.51.51.6-1.6-1.51.50.6-1.30.8
Bone: cortical thickness0.20.20.70.3-0.30.00.00.1-0.00.30.3-0.3-0.40.60.6-0.6-0.80.8-0.8
Bone: cortical tissue density0.50.71.41.1-1.1-0.9-0.9-1.10.9-1.2-0.80.80.8-0.9-0.60.6-0.2-0.3-0.1
Condit. Reinf. active minus inactive responses3.13.55.0-2.12.22.22.22.2-2.22.22.2-2.1-2.01.71.7-1.60.40.70.0
Condit. Reinf. active-inactive response ratio2.02.12.9-1.21.21.61.51.6-1.61.71.7-1.7-1.71.61.6-1.6-0.51.2-0.7
Condit. Reinf. active responses2.53.15.8-2.42.42.12.22.1-2.21.91.9-1.8-1.61.11.1-0.91.3-0.10.9
Condit. Reinf. inactive responses0.70.92.3-1.41.50.91.00.9-1.00.70.7-0.5-0.3-0.1-0.10.21.5-0.91.4
Incentive salience index mean1.51.83.7-1.91.91.71.71.7-1.71.41.5-1.4-1.20.80.8-0.61.1-0.20.8
Condit. Reinf. lever presses0.81.14.1-0.90.90.20.20.1-0.2-0.3-0.20.40.7-1.1-1.11.22.0-1.82.0
Condit. Reinf. active minus inactive responses2.43.04.1-1.31.21.81.71.7-1.71.91.9-2.0-2.02.02.0-2.0-0.81.6-1.1
Condit. Reinf. active-inactive response ratio1.01.02.80.4-0.40.30.20.3-0.30.70.7-0.7-0.91.21.3-1.4-1.61.7-1.7
Condit. Reinf. active responses1.92.63.7-1.71.71.91.91.9-1.91.91.9-1.8-1.81.61.6-1.50.00.9-0.3
Condit. Reinf. inactive responses0.91.12.4-1.61.61.31.31.3-1.31.11.1-1.1-0.90.60.6-0.50.9-0.20.7
Condit. Reinf. lever presses2.23.04.1-1.41.41.91.81.9-1.82.02.0-2.0-2.02.02.0-1.9-0.61.5-0.9
Condit. Reinf. lever reinforcers received1.62.23.1-1.41.41.61.61.7-1.61.81.7-1.7-1.71.61.6-1.6-0.31.1-0.6
Conditioned reinforcement - actives2.02.03.1-1.71.71.51.81.7-1.71.61.7-1.6-1.51.21.3-1.20.20.70.2
Conditioned reinforcement - inactives0.50.61.91.3-1.4-0.4-0.8-0.90.9-0.6-0.60.50.4-0.0-0.2-0.1-0.70.3-1.1
Conditioned locomotion6.47.710.6-3.13.03.33.23.3-3.33.23.2-3.2-3.02.72.7-2.50.21.4-0.3
Patch foraging indifference point 0 sec0.20.30.50.5-0.5-0.2-0.4-0.60.5-0.6-0.50.60.6-0.5-0.70.60.4-0.60.2
Patch foraging indifference point AUC0.91.01.4-1.01.10.81.11.2-1.11.11.2-1.2-1.21.01.2-1.0-0.40.9-0.2
Delay disc. indifference point, 0s delay7.58.211.62.0-2.0-2.8-2.7-2.82.8-3.1-3.13.23.4-3.4-3.43.41.8-3.02.2
Delay disc. indifference point, 16s delay0.10.10.30.3-0.3-0.4-0.4-0.40.4-0.4-0.40.40.4-0.4-0.50.40.2-0.40.3
Delay disc. indifference point, 2s delay5.35.87.82.1-2.0-2.7-2.5-2.62.6-2.7-2.72.82.8-2.7-2.72.70.9-2.01.3
Delay disc. indifference point, 24s delay0.40.41.20.6-0.6-1.1-0.8-0.70.7-0.7-0.80.70.7-0.6-0.60.5-0.3-0.10.2
Delay disc. indifference point, 4s delay1.51.52.50.5-0.5-1.2-1.1-1.01.0-1.2-1.31.31.4-1.5-1.61.61.1-1.51.3
Delay disc. indifference point, 8s delay0.70.81.51.2-1.2-0.9-1.2-1.01.1-0.9-1.00.90.8-0.5-0.60.5-0.5-0.1-0.5
Indifference point function ln k0.20.30.50.7-0.7-0.3-0.6-0.60.6-0.6-0.60.50.5-0.4-0.50.40.0-0.3-0.2
Indifference point function log k0.20.30.50.7-0.7-0.3-0.6-0.60.6-0.6-0.60.50.5-0.4-0.50.40.0-0.3-0.2
Patch foraging total patch changes 0 sec0.10.20.30.5-0.5-0.1-0.4-0.50.4-0.5-0.40.40.5-0.4-0.50.40.2-0.4-0.0
Patch foraging total patch changes 12 sec0.30.41.20.9-0.9-0.9-0.7-0.60.6-0.4-0.40.30.20.00.1-0.2-1.10.7-0.8
Patch foraging total patch changes 18 sec0.81.01.5-1.01.01.11.21.2-1.21.11.2-1.2-1.21.01.1-1.0-0.10.7-0.1
Patch foraging total patch changes 24 sec0.10.10.2-0.40.5-0.10.30.4-0.30.40.3-0.3-0.20.10.2-0.10.00.20.3
Patch foraging total patch changes 6 sec0.10.20.8-0.40.40.90.60.4-0.50.40.6-0.5-0.40.40.3-0.40.3-0.0-0.2
Patch foraging time to switch 0 sec1.82.84.41.0-1.0-1.3-1.5-1.61.6-1.7-1.81.92.0-2.0-2.12.11.3-1.91.3
Patch foraging water rate 0 sec0.50.82.50.4-0.50.10.10.2-0.20.50.6-0.6-0.81.01.1-1.2-1.61.6-1.5
Patch foraging water rate 12 sec0.91.43.61.7-1.8-1.4-1.3-1.21.2-0.9-0.80.70.4-0.10.1-0.3-1.91.2-1.4
Patch foraging water rate 18 sec1.92.57.80.8-0.80.10.20.3-0.30.81.0-1.1-1.41.82.0-2.1-2.82.7-2.6
Patch foraging water rate 24 sec1.72.39.31.7-1.9-0.4-0.7-0.60.60.10.1-0.3-0.71.41.3-1.6-2.82.4-3.0
Patch foraging water rate 6 sec1.21.84.20.0-0.00.70.60.8-0.71.21.1-1.2-1.41.71.7-1.8-1.82.0-1.9
Seeking ratio, delayed vs. immediate footshock3.64.27.2-2.72.72.62.52.5-2.52.32.2-2.2-2.01.61.5-1.41.00.40.5
Distance traveled before self-admin0.30.30.50.2-0.3-0.6-0.6-0.50.5-0.6-0.50.60.7-0.6-0.60.70.2-0.60.5
Distance traveled after self-admin0.70.81.5-1.21.21.11.01.1-1.01.01.0-0.9-0.80.70.7-0.50.40.10.2
Extensor digitorum longus weight3.212.521.64.7-4.6-4.3-4.5-4.44.4-4.0-3.93.83.4-2.6-2.52.2-2.1-0.2-1.2
Bone: elastic displacement0.20.20.4-0.60.60.60.60.6-0.60.60.5-0.5-0.50.40.4-0.30.20.10.1
Bone: elastic work0.30.30.60.2-0.2-0.3-0.4-0.50.4-0.6-0.60.60.7-0.7-0.70.80.6-0.80.7
Bone: endosteal estimation0.30.71.20.2-0.3-0.6-0.6-0.70.6-0.9-0.80.80.9-1.1-1.01.10.8-1.10.9
Bone: endosteal perimeter0.30.62.0-1.21.20.80.80.7-0.70.30.4-0.3-0.1-0.3-0.20.41.4-1.01.3
Epididymis fat weight0.30.61.1-0.30.30.50.60.6-0.60.80.8-0.8-0.91.01.0-1.0-0.81.0-0.8
Delta time in closed arm before/after self-admin1.41.45.31.6-1.4-1.0-0.8-0.70.8-0.2-0.30.1-0.20.70.7-0.9-2.31.8-2.0
Delta time in open arm before/after self-admin1.21.11.61.0-1.1-0.9-1.2-1.21.2-1.3-1.21.21.2-1.1-1.21.10.4-0.90.3
Diff in mean of infusions in LGA sessions1.31.41.9-1.31.21.31.31.4-1.41.31.4-1.4-1.31.21.2-1.1-0.10.7-0.2
Delay discount exponential model param1.71.82.4-1.21.21.51.51.4-1.51.51.5-1.6-1.61.41.5-1.4-0.41.1-0.6
Extinction: sum of active levers before priming1.81.83.1-0.50.51.11.11.1-1.11.31.4-1.5-1.61.61.7-1.8-1.21.7-1.4
Active lever presses in extinction session 62.42.43.5-1.91.81.81.91.8-1.91.71.8-1.7-1.61.31.5-1.30.10.60.1
Bone: final force1.42.33.80.7-0.7-1.3-1.3-1.41.3-1.7-1.61.71.8-1.9-1.92.01.2-1.81.4
Bone: final moment1.21.93.20.6-0.6-1.2-1.1-1.21.2-1.5-1.41.51.6-1.8-1.71.81.1-1.71.3
Food consumed during 24 hour testing period0.40.40.60.8-0.8-0.8-0.8-0.80.8-0.8-0.70.70.7-0.6-0.60.5-0.2-0.2-0.0
Glucose0.91.32.11.4-1.4-1.4-1.5-1.31.4-1.2-1.31.31.2-0.9-1.00.9-0.4-0.3-0.2
Heart weight0.50.71.3-0.50.40.50.60.8-0.70.90.8-0.9-1.01.11.1-1.1-0.91.2-0.8
Delay discount hyperbolic model param2.52.63.5-1.41.41.81.81.7-1.81.81.9-1.9-1.91.71.8-1.7-0.51.3-0.7
Intermittent access intake day 1-15 change5.95.88.8-2.22.23.02.72.7-2.72.82.8-2.8-2.72.52.5-2.5-0.11.5-0.8
Intermittent access intake escalation6.76.69.2-1.71.72.92.62.6-2.62.92.9-3.0-3.03.03.0-3.0-1.12.3-1.8
Intermittent access intake escalation 27.97.810.8-2.12.13.02.82.9-2.93.23.2-3.2-3.33.23.2-3.2-1.22.5-1.7
Intermitt. access day 1 inactive lever presses0.70.81.3-0.30.30.70.60.7-0.60.90.9-0.9-1.01.11.1-1.2-0.81.1-1.0
Intermitt. access day 15 inactive lever presses0.50.50.9-0.30.21.00.70.6-0.70.70.8-0.8-0.90.90.8-0.9-0.30.6-0.8
Intermitt. access escalation Index0.90.82.2-0.20.2-0.6-0.4-0.40.4-0.8-0.70.80.9-1.2-1.11.21.2-1.31.5
Intermittent access day 1 total infusions0.10.10.20.2-0.3-0.2-0.2-0.30.3-0.4-0.30.30.3-0.4-0.40.30.2-0.40.2
Intermittent access day 15 total infusions1.82.03.0-0.90.91.71.51.4-1.51.51.7-1.7-1.71.61.6-1.7-0.51.1-0.9
Intermittent access terminal intake (last 3 days)0.91.01.5-1.01.01.11.21.1-1.21.01.2-1.2-1.20.91.0-1.0-0.10.6-0.1
Intermittent access total infusions0.20.20.4-0.10.10.70.50.4-0.40.40.6-0.6-0.60.50.5-0.6-0.20.4-0.5
Intermittent access day 1 locomotion0.30.30.7-0.30.20.80.60.5-0.50.50.6-0.6-0.60.60.6-0.7-0.10.4-0.5
Intermittent access day 15 total locomotion3.13.35.5-1.61.52.32.02.0-2.02.02.2-2.1-2.11.91.9-1.9-0.21.2-0.8
Intermittent access total locomotion0.81.02.0-1.00.91.41.21.1-1.11.01.2-1.1-1.10.90.9-1.00.10.4-0.3
Intermittent access standard deviation3.03.14.3-1.51.51.91.91.9-1.92.02.1-2.1-2.11.92.0-1.9-0.51.4-0.8
Left kidney weight0.10.31.7-0.80.9-0.10.30.3-0.30.00.0-0.00.1-0.5-0.30.50.8-0.71.3
Right kidney weight1.13.15.3-2.32.31.92.12.1-2.12.02.0-1.9-1.81.41.5-1.30.50.60.4
Cocaine induced anxiety0.70.82.3-1.51.50.61.01.0-1.00.70.6-0.6-0.40.00.10.11.1-0.61.3
Post-drug Anxiety0.70.83.3-1.41.50.10.70.7-0.70.40.3-0.20.0-0.5-0.30.61.3-0.91.8
Baseline Anxiety0.10.20.50.2-0.20.10.10.0-0.10.20.3-0.3-0.40.40.5-0.5-0.70.7-0.6
Tail length2.78.211.4-2.72.63.43.23.2-3.23.33.3-3.3-3.23.13.0-2.9-0.41.9-1.1
Length with tail1.45.310.2-2.72.63.22.82.7-2.72.62.6-2.5-2.32.11.9-1.80.90.5-0.1
Length without tail0.20.52.7-0.80.70.80.40.2-0.30.0-0.00.10.3-0.4-0.70.71.6-1.31.0
Times rat made contact with spout0.20.30.80.7-0.7-0.5-0.5-0.40.5-0.2-0.30.20.10.20.1-0.2-0.90.6-0.8
Lifetime Intake0.00.10.1-0.10.10.30.40.2-0.30.10.3-0.3-0.30.10.3-0.3-0.10.1-0.1
Liver weight, left1.82.95.42.2-2.1-2.3-2.2-2.02.1-1.9-1.91.81.6-1.3-1.21.1-1.0-0.1-0.4
Liver weight, right1.42.33.21.6-1.6-1.8-1.8-1.71.8-1.7-1.81.71.7-1.5-1.51.4-0.0-0.80.2
Locomotor activity2.54.07.8-2.82.72.82.52.4-2.42.02.1-2.0-1.71.21.0-0.91.7-0.41.0
Locomotor testing distance1.52.44.6-2.12.02.12.01.8-1.91.61.7-1.6-1.41.01.0-0.91.1-0.10.6
Locomotor testing rearing0.10.10.20.0-0.10.10.20.2-0.20.20.3-0.3-0.40.30.4-0.4-0.40.5-0.4
Locomotion in novel chamber0.50.71.2-0.60.70.40.60.8-0.70.90.8-0.9-0.90.91.1-1.0-0.81.1-0.3
Locomotion in novel chamber post-restriction0.60.71.1-0.91.00.91.01.0-1.01.00.9-0.9-0.90.70.8-0.7-0.00.40.0
Fecal boli incidents, locomotor time 11.41.53.61.8-1.9-1.3-1.5-1.51.5-1.3-1.21.10.9-0.7-0.50.4-1.20.3-1.0
Change in fecal boli incidents, locomotor task0.60.62.0-1.11.10.50.70.6-0.60.30.3-0.2-0.0-0.3-0.30.51.4-1.01.4
Time >=10cm from walls, locomotor time 10.60.61.40.1-0.1-0.5-0.5-0.60.5-0.7-0.60.80.9-1.1-1.01.01.0-1.21.1
Bouts of movement, locomotor time 10.10.20.3-0.30.30.50.40.4-0.40.40.5-0.5-0.50.40.5-0.5-0.20.4-0.2
Total resting periods, locomotor time 10.20.20.3-0.50.40.60.50.5-0.50.40.6-0.5-0.50.30.4-0.40.10.2-0.0
Rest time, locomotor task time 10.10.20.3-0.60.50.50.50.4-0.50.30.5-0.4-0.30.10.2-0.10.4-0.10.4
Distance moved, locomotor task time 10.80.92.00.2-0.1-0.6-0.6-0.60.6-0.8-0.90.91.0-1.1-1.31.21.3-1.41.2
Vertical activity count, locomotor time 10.00.00.10.3-0.3-0.1-0.2-0.20.2-0.1-0.20.10.10.1-0.0-0.0-0.20.1-0.4
Time >=10cm from walls, locomotor time 20.70.81.71.3-1.3-1.0-1.1-1.11.1-1.0-0.80.90.8-0.5-0.50.4-0.70.1-0.5
Bouts of movement, locomotor time 20.40.51.4-1.01.00.60.70.7-0.70.40.4-0.3-0.1-0.1-0.20.31.2-0.81.1
Total resting periods, locomotor time 20.50.51.6-1.01.10.50.60.6-0.60.40.4-0.2-0.1-0.2-0.30.41.3-0.91.2
Rest time, locomotor task time 20.40.41.1-1.01.00.70.80.8-0.80.50.7-0.5-0.40.10.1-0.10.8-0.40.8
Distance moved, locomotor task time 20.50.61.51.2-1.2-0.8-1.0-1.01.0-0.8-0.80.70.6-0.3-0.30.2-0.80.3-0.8
Vertical activity count, locomotor time 20.70.82.01.4-1.4-0.7-0.9-1.00.9-0.7-0.50.50.30.10.2-0.2-1.40.8-1.3
Light reinforcement 14.37.813.0-3.23.23.63.33.3-3.33.23.1-3.1-2.92.62.4-2.30.71.0-0.0
Light reinforcement 21.31.73.8-1.41.42.01.61.5-1.61.41.5-1.5-1.41.21.1-1.10.50.3-0.1
Bone: marrow area0.30.71.20.3-0.3-0.6-0.6-0.70.6-0.9-0.80.90.9-1.1-1.01.10.8-1.10.9
Bone: maximum diameter0.61.23.1-1.61.61.21.21.0-1.10.60.8-0.6-0.4-0.2-0.10.31.7-1.11.6
Bone: maximum force1.32.33.60.9-0.9-1.4-1.4-1.51.4-1.8-1.61.71.8-1.9-1.81.80.9-1.61.2
Bone: maximum moment1.12.03.20.8-0.8-1.2-1.2-1.41.3-1.7-1.51.51.6-1.8-1.71.70.9-1.51.1
Mean time between licks in bursts3.54.96.6-2.02.02.52.42.4-2.42.52.6-2.6-2.52.42.4-2.3-0.51.6-0.9
Mean num. licks in bursts0.10.10.3-0.20.2-0.2-0.10.00.1-0.1-0.30.30.3-0.3-0.40.50.5-0.50.6
Cd content in liver0.20.20.30.4-0.3-0.4-0.4-0.50.5-0.5-0.50.50.5-0.5-0.50.50.1-0.40.2
Co content in liver0.60.71.1-0.60.60.90.80.8-0.80.90.9-0.9-1.01.01.0-1.0-0.50.8-0.6
Cu content in liver0.50.61.6-0.30.2-0.1-0.2-0.30.2-0.5-0.50.60.7-0.9-1.01.01.3-1.31.2
Fe content in liver0.10.20.60.2-0.20.00.10.1-0.10.20.2-0.3-0.40.50.5-0.5-0.70.7-0.7
K content in liver0.40.41.7-0.60.7-0.00.00.1-0.1-0.2-0.20.30.4-0.6-0.70.81.1-1.01.3
Mg content in liver0.60.62.5-0.70.8-0.10.10.1-0.1-0.2-0.20.30.5-0.8-0.80.91.4-1.21.6
Mn content in liver1.71.96.2-2.02.01.01.21.1-1.10.50.5-0.30.1-0.7-0.70.92.5-1.92.5
Na content in liver1.11.21.90.7-0.6-0.9-1.0-1.11.0-1.2-1.21.21.3-1.3-1.41.40.7-1.30.9
Rb content in liver0.91.12.5-0.00.1-0.7-0.5-0.60.6-0.9-0.91.01.2-1.4-1.41.51.3-1.61.6
Se content in liver0.10.10.3-0.60.60.40.50.5-0.50.40.4-0.4-0.30.20.2-0.20.3-0.00.3
Sr content in liver0.50.51.80.5-0.50.1-0.00.00.00.30.3-0.4-0.50.80.8-0.9-1.31.2-1.3
Zn content in liver3.03.45.9-0.70.81.41.31.5-1.41.91.9-1.9-2.12.32.4-2.4-1.72.4-1.9
Bone: minimum diameter0.20.41.3-0.40.4-0.00.0-0.10.0-0.4-0.30.40.5-0.8-0.70.81.1-1.11.1
Time in familiar zone, hab. session 11.91.82.5-1.21.21.41.51.5-1.41.61.5-1.5-1.51.51.4-1.4-0.31.0-0.6
Time in novel zone, hab. session 11.41.42.40.5-0.5-0.9-0.9-1.00.9-1.2-1.11.21.4-1.5-1.51.51.2-1.51.3
Total zone transitions, hab. session 10.81.12.7-1.61.61.01.21.1-1.10.80.8-0.7-0.40.0-0.00.21.6-0.91.4
Total locomotion distance, hab. session 11.42.06.3-2.02.11.11.31.2-1.20.80.6-0.5-0.1-0.4-0.50.82.5-1.72.3
Locomotion velocity, hab. session 11.31.94.6-2.12.11.41.51.5-1.51.11.0-0.8-0.50.1-0.00.22.1-1.21.8
Time in familiar zone, hab. session 25.86.08.0-2.12.12.62.62.7-2.62.82.7-2.8-2.82.82.7-2.7-0.82.0-1.3
Time in novel zone, hab. session 24.64.66.51.6-1.6-2.2-2.1-2.22.2-2.4-2.42.42.5-2.5-2.52.51.0-2.01.4
Total zone transitions, hab. session 21.11.43.7-0.30.4-0.5-0.4-0.40.4-0.7-0.80.91.2-1.4-1.51.61.8-1.91.9
Total locomotion distance, hab. session 20.70.92.5-1.51.60.91.11.1-1.00.90.7-0.6-0.40.1-0.00.21.4-0.81.3
Locomotion velocity, hab. session 20.81.13.2-1.61.70.91.01.0-1.00.70.6-0.5-0.2-0.1-0.30.41.8-1.11.6
Novel to familiar place preference ratio4.34.46.41.3-1.3-2.1-2.0-2.02.0-2.3-2.32.42.5-2.5-2.52.51.3-2.21.7
Novelty place preference2.82.84.40.9-0.9-1.6-1.5-1.51.5-1.8-1.81.92.0-2.1-2.12.11.3-1.91.6
Time in novel zone, NPP test3.03.04.51.0-1.0-1.7-1.6-1.61.6-1.9-1.92.02.1-2.1-2.12.11.2-1.91.5
Total zone transitions, NPP test0.20.30.9-0.30.3-0.2-0.1-0.10.1-0.2-0.30.40.5-0.6-0.70.70.9-0.91.0
Total locomotion distance, NPP test0.50.62.0-0.40.5-0.2-0.1-0.10.1-0.3-0.50.50.7-0.9-1.01.11.4-1.31.4
Locomotion velocity, NPP test0.30.51.8-0.70.70.10.20.2-0.2-0.0-0.20.20.4-0.6-0.70.81.3-1.11.3
Intraocular pressure0.60.93.20.4-0.4-0.20.00.2-0.10.50.4-0.6-0.81.01.2-1.2-1.81.8-1.5
Delta distance traveled before/after self-admin1.21.32.2-1.31.31.51.41.4-1.31.31.3-1.3-1.21.10.9-0.90.40.3-0.1
Delta ambulatory time before/after self-admin1.21.42.5-1.61.61.31.51.4-1.41.31.3-1.2-1.10.80.8-0.70.60.20.4
Parametrial fat weight0.40.81.4-0.80.61.21.00.9-1.01.01.0-1.1-1.01.10.9-1.0-0.10.6-0.6
Pavlov. Cond. lever latency0.40.61.90.5-0.50.10.00.0-0.00.30.4-0.4-0.60.80.9-1.0-1.31.3-1.4
Pavlov. Cond. magazine entry latency2.22.83.9-1.71.71.91.91.9-1.91.92.0-2.0-1.91.71.7-1.7-0.11.0-0.4
Pavlov. Cond. change in total contacts0.00.00.1-0.30.30.20.20.3-0.20.30.2-0.2-0.20.10.1-0.10.2-0.00.1
Pavlov. Cond. index score0.30.40.9-0.91.00.60.70.7-0.70.50.5-0.4-0.30.00.00.10.9-0.50.8
Pavlov. Cond. latency score0.40.51.7-1.11.10.60.70.7-0.70.40.4-0.3-0.1-0.2-0.20.31.3-0.91.2
Pavlov. Cond. lever contacts0.60.72.6-0.80.80.10.20.2-0.2-0.1-0.20.30.5-0.8-0.80.91.6-1.41.6
Pavlov. Cond. magazine entry number0.40.60.80.8-0.8-0.9-0.9-0.90.9-0.8-0.90.90.8-0.7-0.70.6-0.1-0.30.0
Pavlov. Cond. intertrial magazine entries0.40.41.10.1-0.10.30.30.3-0.30.50.6-0.6-0.70.80.9-0.9-1.01.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.61.4-1.21.20.91.00.9-1.00.80.8-0.7-0.60.30.3-0.20.9-0.30.7
Pavlov. Cond. response bias0.80.91.4-1.11.11.11.21.1-1.21.11.1-1.1-1.00.80.8-0.80.30.30.1
Pavlov. Cond. lever latency0.70.91.41.2-1.2-1.2-1.2-1.21.2-1.1-1.01.01.0-0.8-0.80.7-0.3-0.3-0.1
Pavlov. Cond. magazine entry latency0.40.40.9-0.90.90.80.80.8-0.80.60.7-0.7-0.60.40.4-0.30.6-0.10.4
Pavlov. Cond. change in total contacts0.71.01.5-1.11.11.21.11.2-1.21.21.1-1.1-1.11.11.0-0.9-0.00.6-0.2
Pavlov. Cond. index score0.81.01.5-1.21.11.21.21.2-1.21.11.1-1.1-1.00.90.9-0.80.20.40.0
Pavlov. Cond. latency score0.70.81.4-1.21.11.21.11.1-1.11.01.0-1.0-0.90.70.7-0.60.50.10.3
Pavlov. Cond. lever contacts0.71.01.4-1.01.01.11.11.1-1.11.21.1-1.1-1.11.11.0-1.0-0.10.7-0.3
Pavlov. Cond. magazine entry number0.60.81.51.2-1.2-1.1-1.1-1.11.1-0.9-1.00.90.8-0.6-0.60.5-0.60.1-0.5
Pavlov. Cond. intertrial magazine entries0.30.41.21.1-1.1-0.7-0.7-0.80.7-0.6-0.40.40.3-0.2-0.1-0.1-0.90.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.5-1.21.21.21.21.2-1.21.11.1-1.1-1.00.80.8-0.70.40.20.2
Pavlov. Cond. response bias1.62.23.0-1.51.51.71.71.7-1.71.71.7-1.7-1.71.61.6-1.5-0.21.0-0.4
Time in closed arm before self-admin1.31.42.80.4-0.5-0.7-0.9-1.00.9-1.2-1.31.31.4-1.5-1.61.61.4-1.71.1
Time in closed arm after self-admin0.00.00.1-0.10.2-0.20.10.2-0.10.30.1-0.1-0.10.20.2-0.1-0.20.3-0.1
Time in open arm before self-admin1.11.11.6-1.01.01.01.11.2-1.11.31.2-1.2-1.21.21.2-1.2-0.40.9-0.4
Time in open arm after self-admin0.50.61.31.0-1.1-0.6-1.0-1.00.9-0.9-0.80.80.7-0.5-0.60.5-0.2-0.2-0.3
Bone: periosteal estimation0.81.63.60.1-0.1-0.7-0.6-0.90.7-1.3-1.11.21.4-1.7-1.61.71.6-1.91.7
Bone: periosteal perimeter0.50.82.9-0.90.90.40.40.2-0.3-0.2-0.00.20.4-0.9-0.80.91.7-1.51.6
Bone: post-yield work0.50.71.11.0-1.0-0.9-0.9-1.10.9-1.1-0.80.90.8-0.9-0.70.7-0.1-0.40.0
Progressive ratio test 1 active lever presses0.10.10.40.6-0.7-0.3-0.3-0.40.4-0.3-0.20.20.1-0.1-0.0-0.1-0.50.2-0.5
Progressive ratio test 1 breakpoint0.10.20.40.6-0.7-0.5-0.4-0.50.5-0.5-0.30.30.3-0.3-0.20.1-0.40.1-0.3
Progressive ratio test 1 inactive lever presses0.00.00.0-0.10.00.20.10.0-0.10.00.1-0.1-0.1-0.0-0.0-0.00.1-0.1-0.0
Progressive ratio test 2 active lever presses0.30.40.7-0.20.20.40.50.5-0.50.60.7-0.7-0.70.70.8-0.8-0.60.8-0.6
Progressive ratio test 2 breakpoint0.30.30.5-0.60.60.40.60.6-0.60.60.7-0.6-0.60.40.6-0.6-0.20.4-0.0
Progressive ratio test 2 inactive lever presses0.00.00.1-0.30.20.30.30.2-0.30.10.2-0.2-0.20.10.1-0.10.2-0.10.1
Incentive Sensitization - Responses0.50.51.0-0.30.40.30.60.6-0.60.70.8-0.8-0.80.81.0-0.9-0.71.0-0.5
Incentive Sensitization - Breakpoint0.50.50.9-0.50.60.30.60.7-0.70.80.8-0.8-0.80.70.9-0.8-0.60.9-0.3
Sum of active levers in priming session hrs 5-60.00.00.10.2-0.20.2-0.0-0.00.0-0.00.1-0.1-0.10.10.2-0.2-0.20.2-0.3
Progressive ratio0.20.20.80.6-0.5-0.8-0.6-0.40.5-0.3-0.30.30.20.00.1-0.1-0.90.6-0.4
Food seeking constrained by brief footshock0.10.10.2-0.40.50.20.40.4-0.30.50.3-0.3-0.30.30.3-0.2-0.10.3-0.0
Seeking ratio, punishment vs. effort0.10.10.5-0.40.40.70.50.3-0.40.30.3-0.3-0.20.1-0.0-0.00.6-0.40.1
Retroperitoneal fat weight0.31.02.91.5-1.7-0.7-1.2-1.41.2-1.2-1.01.00.8-0.6-0.70.4-0.5-0.2-0.9
Reaction time number correct0.60.82.41.3-1.3-1.1-0.9-0.90.9-0.5-0.50.40.20.10.2-0.3-1.61.0-1.2
Reaction time mean minus median0.60.71.2-1.11.10.81.01.1-1.10.91.1-1.0-0.90.60.8-0.70.20.30.3
Reaction time mean minus median AUC0.50.73.0-0.70.7-0.10.20.1-0.2-0.4-0.20.30.5-1.0-0.81.01.5-1.31.7
Reaction time num false alarms0.10.10.40.4-0.3-0.3-0.2-0.20.2-0.0-0.00.0-0.10.10.2-0.2-0.70.5-0.4
Reaction time num false alarms AUC0.20.31.30.7-0.6-0.5-0.4-0.30.3-0.1-0.10.0-0.10.20.4-0.4-1.10.9-0.8
Reaction time trials correct on left0.60.82.41.3-1.3-1.1-0.9-0.90.9-0.5-0.50.40.20.10.2-0.3-1.61.0-1.2
Reaction time trials on left0.50.82.21.3-1.3-1.1-0.9-0.90.9-0.6-0.50.50.30.00.1-0.2-1.50.9-1.1
Reaction time mean0.30.41.7-0.50.4-0.20.0-0.1-0.0-0.4-0.20.30.5-0.9-0.70.81.1-1.11.3
Reaction time mean AUC0.40.51.6-0.40.3-0.2-0.0-0.20.1-0.5-0.30.40.6-0.9-0.80.91.1-1.11.3
Median of all reaction times0.60.91.80.0-0.1-0.7-0.5-0.60.5-1.0-0.70.91.0-1.3-1.11.21.1-1.31.3
Reaction time omissions0.20.20.4-0.60.60.60.60.5-0.60.40.6-0.5-0.40.20.3-0.20.4-0.10.4
Reaction time false alarm rate0.00.00.00.00.1-0.1-0.1-0.00.0-0.1-0.10.10.1-0.2-0.10.10.0-0.00.2
Reaction time premature initiation rate1.21.62.5-0.70.61.51.11.1-1.11.41.4-1.4-1.51.61.5-1.5-0.71.2-1.2
Reaction time premature initiations1.21.83.8-0.0-0.11.00.70.7-0.81.21.2-1.3-1.51.71.7-1.8-1.61.8-1.9
Std. dev. reaction times0.20.30.7-0.80.80.20.60.6-0.70.20.5-0.4-0.3-0.10.2-0.00.6-0.30.8
Reaction time trials completed0.50.82.21.3-1.3-1.1-0.9-0.90.9-0.6-0.50.50.30.00.1-0.2-1.50.9-1.1
Reaction time trials AUC0.60.93.01.4-1.4-1.0-0.9-0.80.8-0.5-0.40.40.10.20.3-0.4-1.71.2-1.4
Run reversals in cocaine runway, females0.50.51.9-1.21.40.40.80.9-0.80.80.6-0.5-0.40.20.2-0.00.7-0.20.9
Run reversals in cocaine runway, males0.90.92.4-1.51.60.91.21.2-1.21.11.0-0.9-0.80.50.5-0.40.6-0.00.7
Latency to leave start box in cocaine runway0.91.02.3-1.51.41.31.21.0-1.10.60.8-0.7-0.4-0.10.00.11.5-1.01.3
Latency to leave start box in cocaine runway, F1.11.24.5-0.90.80.10.30.0-0.1-0.5-0.30.40.7-1.3-1.21.32.0-1.92.1
Latency to leave start box in cocaine runway, M3.13.04.6-1.11.01.81.61.7-1.71.81.9-2.0-2.12.12.1-2.1-1.01.8-1.3
Std. dev. time between licks in bursts0.70.81.9-1.41.31.01.11.0-1.00.70.8-0.7-0.50.10.1-0.01.2-0.71.1
Total sessions with >9 infusions0.20.21.1-0.50.5-0.30.20.1-0.1-0.2-0.10.10.2-0.6-0.40.50.6-0.61.1
Short access day 1 total inactive lever presses0.00.00.1-0.10.10.10.20.2-0.20.20.2-0.2-0.20.20.2-0.2-0.10.2-0.1
Short access day 10 total inactive lever presses0.20.30.80.1-0.20.40.20.2-0.20.40.4-0.4-0.50.70.6-0.7-0.60.7-0.9
Short access day 1 total infusions0.30.31.2-0.70.70.10.50.3-0.4-0.00.1-0.10.1-0.5-0.30.40.8-0.71.1
Short access day 10 total infusions0.00.00.10.0-0.0-0.20.20.0-0.1-0.10.2-0.2-0.2-0.10.2-0.2-0.30.30.0
Short access total infusions0.10.10.6-0.30.3-0.40.20.0-0.1-0.2-0.00.10.1-0.5-0.20.30.2-0.20.7
Short access day 1 locomotion0.60.72.1-1.00.91.51.20.9-1.00.70.9-0.8-0.70.30.3-0.41.0-0.40.4
Short access day 10 total locomotion3.74.26.3-1.71.72.52.32.2-2.32.32.4-2.4-2.42.22.2-2.2-0.31.4-0.9
Short access total locomotion0.70.71.4-1.11.01.11.21.0-1.10.81.0-1.0-0.90.60.7-0.60.40.10.2
One hour access (0.3 mA shock)0.20.20.40.7-0.7-0.2-0.4-0.60.5-0.5-0.40.40.4-0.4-0.40.30.0-0.2-0.2
Compulsive drug intake0.90.91.40.8-0.7-0.8-1.0-1.01.0-0.9-1.21.11.2-0.9-1.21.10.5-0.90.4
One hour access (shock baseline)0.20.20.60.2-0.30.40.20.1-0.20.20.4-0.4-0.50.50.5-0.7-0.50.6-0.8
Social response proportion0.40.51.2-1.11.10.60.80.9-0.80.80.6-0.6-0.50.40.4-0.20.6-0.10.5
Social responses5.57.013.4-3.73.73.03.33.3-3.23.02.8-2.8-2.52.02.0-1.61.30.41.0
Social time0.50.61.31.1-1.1-0.9-1.0-1.01.0-0.9-0.90.80.8-0.6-0.60.5-0.3-0.2-0.3
Soleus weight6.920.128.75.0-4.9-5.4-5.3-5.35.3-5.2-5.25.14.9-4.2-4.23.9-0.8-1.90.2
Bone: stiffness2.74.36.01.8-1.7-2.2-2.2-2.32.2-2.5-2.32.42.4-2.4-2.32.30.5-1.60.9
Tibialis anterior weight0.82.64.11.6-1.6-1.9-2.0-1.81.9-1.8-1.91.91.8-1.5-1.51.5-0.2-0.70.3
Time to tail flick, vehicle, before self-admin0.70.72.0-1.31.40.50.80.9-0.80.50.4-0.4-0.2-0.2-0.10.41.3-0.81.4
Time to tail flick, vehicle, after self-admin0.50.51.80.0-0.1-0.20.10.3-0.20.60.4-0.5-0.70.90.9-0.9-1.41.4-1.0
Time to tail flick, test, before self-admin0.50.52.5-1.01.0-0.10.50.4-0.40.10.0-0.00.2-0.6-0.40.61.1-0.91.6
Time to tail flick, test, after self-admin0.20.20.7-0.80.8-0.00.50.5-0.40.20.3-0.2-0.1-0.2-0.20.20.6-0.40.8
Delta time to tail flick, vehicle, before/after SA0.90.93.41.2-1.3-0.8-0.8-0.70.8-0.3-0.40.2-0.00.40.5-0.6-1.91.3-1.6
Delta time to tail flick, test, before/after SA0.40.41.20.1-0.10.40.30.3-0.30.50.5-0.5-0.60.90.7-0.8-0.80.9-1.1
Tibia length0.82.23.2-1.41.31.81.61.7-1.61.71.7-1.7-1.71.61.5-1.5-0.10.9-0.5
Ambulatory time before self-admin0.20.20.30.3-0.4-0.5-0.5-0.40.5-0.5-0.40.50.5-0.5-0.50.50.1-0.40.3
Ambulatory time after self-admin0.40.40.9-0.90.80.80.70.8-0.80.70.8-0.7-0.60.50.5-0.40.20.10.1
Bone: tissue strength1.61.62.51.2-1.2-1.3-1.3-1.51.3-1.6-1.41.41.4-1.4-1.31.30.2-0.90.5
Total heroin consumption1.51.72.7-1.71.61.41.61.6-1.61.41.5-1.5-1.41.01.3-1.10.10.60.3
Bone: trabecular number0.91.33.6-1.81.91.01.11.1-1.10.70.6-0.5-0.2-0.2-0.30.51.9-1.21.7
Bone: trabecular spacing1.41.96.81.7-1.7-0.8-0.8-0.70.7-0.1-0.1-0.0-0.41.01.0-1.2-2.62.1-2.5
Bone: trabecular thickness3.03.612.0-1.61.60.20.30.1-0.2-0.7-0.70.91.4-2.0-2.12.43.5-3.23.5
Bone: trabecular tissue density1.62.35.62.3-2.4-1.7-1.8-2.01.8-1.7-1.41.31.1-0.9-0.60.5-1.40.3-1.1
Water consumed over 24 hours0.91.01.90.3-0.3-0.8-0.7-0.80.7-1.0-1.01.01.2-1.3-1.31.31.1-1.41.2
Number of responses in last shaping day0.10.10.3-0.50.40.50.60.4-0.50.30.4-0.4-0.40.20.3-0.30.20.00.1