Hub : Genes

Mrpl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Mrpl2	0.05	0.04	2.1e-03	0.01	0.01	0	0	5.3e-02	4.7e-02	7.3e-02	8.3e-02
2	Brain	gene expression	Mrpl2	0.05	0.05	2.6e-03	0.03	0.01	0.01	0.02	1.5e-03	1.3e-02	3.0e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.4	0.6	0.8	0.9	-0.6
Area under the delay curve	7.2	7.6	9.4	2.4	-3.1
BMI with tail	4.2	13.6	13.8	-3.7	3.7
BMI without tail	13.4	27.7	28.5	-5.2	5.3
Body weight	3.4	14.1	14.8	-3.8	3.7
Weight adjusted by age	0.2	0.2	0.3	-0.4	0.5
Bone surface	1.3	2.3	2.3	1.5	-1.5
Bone volume	0.5	0.8	0.9	0.9	-0.9
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.2	-0.2
Number of licking bursts	2.8	3.3	4.6	-1.4	2.1
Context. condit. distance diff. score	0.3	0.4	0.6	-0.8	0.3
Locomotion velocity, session 1	0.8	0.9	1.4	-1.2	0.6
Locomotion distance, session 1	2.6	3.3	4.0	-2.0	1.6
Locomotion velocity, session 2	6.9	8.1	10.1	-3.2	2.5
Locomotion distance, session 2	1.6	2.3	2.7	-1.7	1.3
Locomotion velocity, session 3	0.8	0.9	1.5	-1.2	0.6
Locomotion distance, session 3	0.6	0.6	1.1	0.4	-1.0
Stereotopy head waving bouts, day 3	1.2	1.4	1.9	-1.0	1.4
Stereotopy head waving duration, day 3	2.0	2.4	2.8	-1.4	1.7
Locomotion velocity, session 7	0.5	0.6	0.9	-1.0	0.4
Locomotion distance, session 7	0.2	0.2	0.4	-0.7	0.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.2	-0.5	0.5
Stereotopy head waving duration, day 7	0.0	0.1	0.1	0.3	-0.1
Locomotion velocity, session 8	0.9	1.0	1.5	-1.2	0.7
Locomotion distance, session 8	1.3	2.0	2.7	-1.6	1.1
Degree of sensitization distance	2.1	2.1	2.1	-1.4	1.4
Degree of sensitization stereotypy	0.4	0.4	0.5	0.5	-0.7
Conditioned locomotion	1.2	1.4	2.1	0.8	-1.4
Cocaine response after cond. corrected	0.4	0.4	0.5	0.7	-0.6
Cocaine response after cond. not corrected	0.5	0.6	0.6	0.8	-0.8
Cocaine response before conditioning	0.1	0.1	0.1	-0.4	0.1
Saline control response	0.1	0.1	0.1	-0.4	-0.1
Bone: connectivity density	1.1	1.7	2.5	1.6	-1.0
Bone: cortical apparent density	0.5	0.6	0.9	0.5	-1.0
Bone: cortical area	1.6	2.4	4.0	-2.0	0.8
Bone: cortical porosity	0.1	0.1	0.1	-0.1	0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.2	0.2
Bone: cortical thickness	2.0	3.2	5.3	-2.3	1.1
Bone: cortical thickness	0.0	0.0	0.0	-0.0	-0.1
Bone: cortical tissue density	0.4	0.5	0.8	0.5	-0.9
Condit. Reinf. active minus inactive responses	1.6	1.8	2.1	-1.2	1.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.2	0.6
Condit. Reinf. active responses	3.1	3.8	3.9	-1.9	2.0
Condit. Reinf. inactive responses	2.6	3.2	3.2	-1.8	1.8
Incentive salience index mean	2.8	3.4	3.9	-2.0	1.7
Condit. Reinf. lever presses	5.0	6.7	7.8	-2.8	2.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.2	0.9
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	-0.1
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.6	0.9
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.2	-0.0
Conditioned reinforcement - actives	0.6	0.6	1.0	0.3	-1.0
Conditioned reinforcement - inactives	0.9	1.0	1.4	-1.2	0.7
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1
Patch foraging indifference point 0 sec	0.7	1.1	1.4	-0.9	1.2
Patch foraging indifference point AUC	1.2	1.4	2.0	-1.4	0.9
Delay disc. indifference point, 0s delay	2.0	2.2	2.9	1.7	-1.2
Delay disc. indifference point, 16s delay	10.4	10.5	12.8	2.9	-3.6
Delay disc. indifference point, 2s delay	2.8	3.1	3.2	1.7	-1.8
Delay disc. indifference point, 24s delay	1.2	1.1	1.4	0.9	-1.2
Delay disc. indifference point, 4s delay	2.0	2.1	3.4	0.9	-1.8
Delay disc. indifference point, 8s delay	4.2	4.4	5.7	1.7	-2.4
Indifference point function ln k	0.7	1.0	1.3	1.2	-0.8
Indifference point function log k	0.7	1.0	1.3	1.2	-0.8
Patch foraging total patch changes 0 sec	0.9	1.4	1.8	-1.0	1.4
Patch foraging total patch changes 12 sec	1.9	2.4	3.6	-1.9	1.1
Patch foraging total patch changes 18 sec	2.1	2.7	3.3	-1.8	1.4
Patch foraging total patch changes 24 sec	1.3	1.6	1.7	-1.3	1.2
Patch foraging total patch changes 6 sec	2.6	3.9	4.4	-2.1	1.8
Patch foraging time to switch 0 sec	4.5	7.0	7.1	2.7	-2.6
Patch foraging water rate 0 sec	3.4	5.5	7.4	-2.7	1.9
Patch foraging water rate 12 sec	6.0	9.1	10.0	-3.2	2.9
Patch foraging water rate 18 sec	1.4	1.9	2.0	-1.4	1.4
Patch foraging water rate 24 sec	1.7	2.4	2.6	-1.5	1.6
Patch foraging water rate 6 sec	0.4	0.5	0.9	-1.0	0.4
Seeking ratio, delayed vs. immediate footshock	2.2	2.5	2.6	1.6	-1.6
Distance traveled before self-admin	0.2	0.2	0.4	-0.6	0.2
Distance traveled after self-admin	3.4	3.8	4.6	-1.7	2.1
Extensor digitorum longus weight	0.1	0.5	0.7	-0.8	0.5
Bone: elastic displacement	0.2	0.2	0.3	0.3	-0.5
Bone: elastic work	0.1	0.2	0.3	-0.5	0.2
Bone: endosteal estimation	0.5	1.2	1.4	1.2	-1.0
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	-0.0
Epididymis fat weight	2.1	4.8	5.3	-2.1	2.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2
Delta time in open arm before/after self-admin	0.5	0.5	0.5	0.7	-0.6
Diff in mean of infusions in LGA sessions	0.5	0.6	0.8	-0.9	0.6
Delay discount exponential model param	6.7	7.0	9.0	-2.2	3.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.0	-0.0
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.6	0.2
Bone: final force	0.8	1.3	2.0	-1.4	0.7
Bone: final moment	0.8	1.3	2.2	-1.5	0.7
Food consumed during 24 hour testing period	0.5	0.7	0.8	-0.9	0.7
Glucose	4.7	7.0	8.0	-2.4	2.8
Heart weight	1.1	1.6	2.3	1.0	-1.5
Delay discount hyperbolic model param	5.9	6.3	8.0	-2.1	2.8
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.7	0.1
Intermittent access intake escalation	0.1	0.1	0.1	-0.4	-0.1
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.8	0.1
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.5	-1.2	1.2
Intermitt. access day 15 inactive lever presses	1.6	1.8	1.8	-1.4	1.3
Intermitt. access escalation Index	0.1	0.1	0.2	0.4	-0.1
Intermittent access day 1 total infusions	0.4	0.4	0.7	-0.4	0.8
Intermittent access day 15 total infusions	0.2	0.2	0.3	-0.4	0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	0.3
Intermittent access total infusions	0.0	0.0	0.1	0.0	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.1	0.5
Intermittent access day 15 total locomotion	0.3	0.3	0.3	-0.6	0.5
Intermittent access total locomotion	0.1	0.1	0.1	0.4	0.1
Intermittent access standard deviation	3.2	3.3	3.6	1.8	-1.9
Left kidney weight	0.5	1.3	2.4	-1.6	0.5
Right kidney weight	0.1	0.4	0.8	-0.9	0.0
Cocaine induced anxiety	0.1	0.1	0.1	-0.1	0.4
Post-drug Anxiety	0.0	0.0	0.0	0.2	0.1
Baseline Anxiety	0.1	0.1	0.2	0.2	-0.5
Tail length	2.4	7.4	7.9	-2.8	2.6
Length with tail	0.3	1.0	1.6	-1.3	0.6
Length without tail	2.3	5.1	6.9	1.8	-2.6
Times rat made contact with spout	4.2	4.8	6.4	-1.8	2.5
Lifetime Intake	0.1	0.1	0.2	0.4	-0.3
Liver weight, left	0.6	0.9	1.4	-1.2	0.7
Liver weight, right	0.9	1.4	1.9	-1.4	1.0
Locomotor activity	2.3	3.6	3.6	-1.9	1.9
Locomotor testing distance	2.0	3.4	3.6	-1.9	1.8
Locomotor testing rearing	3.5	5.5	5.9	-2.4	2.2
Locomotion in novel chamber	0.7	0.9	1.4	0.6	-1.2
Locomotion in novel chamber post-restriction	1.1	1.3	2.2	0.6	-1.5
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.1	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.1	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	-0.6	0.5
Bouts of movement, locomotor time 1	0.5	0.5	1.0	1.0	-0.2
Total resting periods, locomotor time 1	0.1	0.2	0.2	0.4	0.3
Rest time, locomotor task time 1	0.9	0.9	1.1	1.1	-0.9
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.2	0.1
Vertical activity count, locomotor time 1	0.4	0.5	0.7	0.4	-0.8
Time >=10cm from walls, locomotor time 2	0.6	0.6	0.7	-0.9	0.7
Bouts of movement, locomotor time 2	0.4	0.4	0.5	-0.5	0.7
Total resting periods, locomotor time 2	0.1	0.1	0.1	-0.1	0.4
Rest time, locomotor task time 2	0.8	0.9	1.2	1.1	-0.8
Distance moved, locomotor task time 2	0.7	0.8	1.0	-0.7	1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.1	-0.4
Light reinforcement 1	2.3	4.2	4.7	-2.2	1.9
Light reinforcement 2	2.3	3.1	3.6	-1.6	1.9
Bone: marrow area	0.6	1.2	1.3	1.2	-1.1
Bone: maximum diameter	0.4	0.7	1.3	-1.1	0.4
Bone: maximum force	0.1	0.1	0.2	-0.4	0.1
Bone: maximum moment	0.1	0.1	0.2	-0.5	0.0
Mean time between licks in bursts	2.2	3.1	4.4	2.1	-1.3
Mean num. licks in bursts	0.4	0.4	0.6	0.6	-0.7
Cd content in liver	1.2	1.3	1.4	1.2	-1.1
Co content in liver	0.1	0.1	0.1	0.3	0.2
Cu content in liver	0.4	0.4	0.7	0.4	-0.8
Fe content in liver	0.3	0.3	0.6	0.1	-0.8
K content in liver	0.8	0.7	1.1	1.1	-0.6
Mg content in liver	1.5	1.5	2.1	0.9	-1.5
Mn content in liver	0.5	0.6	1.1	0.1	1.1
Na content in liver	0.4	0.4	0.8	-0.9	0.2
Rb content in liver	5.3	6.6	9.0	2.1	-3.0
Se content in liver	0.1	0.1	0.1	-0.2	0.4
Sr content in liver	0.6	0.6	0.7	-0.6	0.9
Zn content in liver	3.7	4.0	5.5	1.6	-2.4
Bone: minimum diameter	0.4	0.7	1.1	-1.0	0.5
Time in familiar zone, hab. session 1	1.3	1.2	2.0	-1.4	0.7
Time in novel zone, hab. session 1	1.7	1.7	2.6	1.6	-0.8
Total zone transitions, hab. session 1	4.6	6.4	6.9	-2.6	2.4
Total locomotion distance, hab. session 1	5.0	7.2	8.0	-2.8	2.5
Locomotion velocity, hab. session 1	4.8	6.7	8.0	-2.8	2.3
Time in familiar zone, hab. session 2	1.7	1.8	2.1	1.2	-1.4
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.3	0.6
Total zone transitions, hab. session 2	2.2	2.9	3.8	-1.4	2.0
Total locomotion distance, hab. session 2	2.7	3.5	4.4	-1.6	2.1
Locomotion velocity, hab. session 2	2.0	2.7	3.5	-1.4	1.9
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	0.4
Novelty place preference	0.0	0.0	0.1	-0.2	0.1
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	0.1
Total zone transitions, NPP test	7.3	10.4	11.0	-3.3	3.1
Total locomotion distance, NPP test	6.1	8.4	8.6	-2.8	2.9
Locomotion velocity, NPP test	7.0	9.9	10.2	-3.2	3.1
Intraocular pressure	1.5	2.0	2.9	1.7	-1.1
Delta distance traveled before/after self-admin	4.1	4.4	6.7	-1.5	2.6
Delta ambulatory time before/after self-admin	3.3	3.6	5.5	-1.3	2.3
Parametrial fat weight	6.6	12.9	13.6	-3.5	3.7
Pavlov. Cond. lever latency	3.8	4.8	6.6	2.6	-1.7
Pavlov. Cond. magazine entry latency	1.2	1.6	2.3	-1.5	0.9
Pavlov. Cond. change in total contacts	2.4	2.6	2.9	-1.7	1.5
Pavlov. Cond. index score	4.0	5.1	7.0	-2.7	1.8
Pavlov. Cond. latency score	3.2	4.0	6.1	-2.5	1.4
Pavlov. Cond. lever contacts	5.1	6.0	7.9	-2.8	2.0
Pavlov. Cond. magazine entry number	2.6	3.3	4.3	2.1	-1.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.3	1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.4	6.1	-2.5	1.7
Pavlov. Cond. response bias	5.5	6.6	8.0	-2.8	2.3
Pavlov. Cond. lever latency	2.4	3.3	3.5	1.7	-1.9
Pavlov. Cond. magazine entry latency	2.2	2.5	2.9	-1.7	1.5
Pavlov. Cond. change in total contacts	2.5	3.5	3.5	-1.8	1.9
Pavlov. Cond. index score	5.0	6.4	6.7	-2.6	2.5
Pavlov. Cond. latency score	5.3	6.6	6.7	-2.6	2.5
Pavlov. Cond. lever contacts	3.0	4.1	4.2	-2.1	2.0
Pavlov. Cond. magazine entry number	1.3	1.6	2.2	1.5	-1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.0
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.2	6.4	-2.5	2.5
Pavlov. Cond. response bias	1.3	1.7	2.1	-1.4	1.2
Time in closed arm before self-admin	0.3	0.3	0.6	0.8	-0.2
Time in closed arm after self-admin	0.3	0.3	0.6	0.8	0.0
Time in open arm before self-admin	3.2	3.5	5.0	-2.2	1.4
Time in open arm after self-admin	0.6	0.6	1.0	-1.0	0.5
Bone: periosteal estimation	0.1	0.2	0.4	-0.7	0.1
Bone: periosteal perimeter	1.1	1.8	2.8	-1.7	0.9
Bone: post-yield work	0.0	0.0	0.1	0.3	-0.0
Progressive ratio test 1 active lever presses	0.7	0.8	1.2	-0.6	1.1
Progressive ratio test 1 breakpoint	0.6	0.7	1.0	-0.6	1.0
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.1	-1.0	0.9
Progressive ratio test 2 active lever presses	1.1	1.2	1.5	-1.2	1.0
Progressive ratio test 2 breakpoint	1.8	2.0	2.2	-1.5	1.3
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	-0.8	0.6
Incentive Sensitization - Responses	1.2	1.3	1.6	-1.3	1.0
Incentive Sensitization - Breakpoint	1.3	1.3	1.7	-1.3	1.0
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.4	-0.9
Progressive ratio	0.3	0.3	0.6	0.2	-0.8
Food seeking constrained by brief footshock	0.0	0.1	0.1	-0.2	0.3
Seeking ratio, punishment vs. effort	0.4	0.5	0.8	-0.4	0.9
Retroperitoneal fat weight	2.1	6.9	8.5	-2.9	2.3
Reaction time number correct	0.0	0.1	0.1	-0.1	-0.3
Reaction time mean minus median	0.1	0.1	0.1	-0.0	-0.4
Reaction time mean minus median AUC	0.4	0.5	0.5	0.7	-0.7
Reaction time num false alarms	0.6	0.9	1.0	0.8	-1.0
Reaction time num false alarms AUC	0.4	0.6	0.8	0.6	-0.9
Reaction time trials correct on left	0.0	0.1	0.1	-0.1	-0.3
Reaction time trials on left	0.0	0.0	0.1	-0.2	-0.2
Reaction time mean	0.2	0.3	0.5	0.7	-0.4
Reaction time mean AUC	0.2	0.3	0.6	0.8	-0.3
Median of all reaction times	0.2	0.2	0.4	0.7	-0.2
Reaction time omissions	0.4	0.6	0.6	-0.8	0.8
Reaction time false alarm rate	0.7	0.9	0.9	1.0	-1.0
Reaction time premature initiation rate	1.0	1.3	1.5	-1.1	1.2
Reaction time premature initiations	1.1	1.5	1.7	-1.3	1.1
Std. dev. reaction times	0.1	0.2	0.2	0.3	-0.5
Reaction time trials completed	0.0	0.0	0.1	-0.2	-0.2
Reaction time trials AUC	0.0	0.1	0.1	-0.3	-0.1
Run reversals in cocaine runway, females	1.1	1.0	1.9	-1.4	0.4
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.1
Latency to leave start box in cocaine runway	2.1	2.3	2.6	-1.6	1.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	-0.3	0.5
Latency to leave start box in cocaine runway, M	5.6	5.4	6.2	-2.5	2.1
Std. dev. time between licks in bursts	1.7	2.0	2.3	1.5	-1.4
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	0.1
Short access day 10 total inactive lever presses	1.0	1.1	1.3	-1.2	0.9
Short access day 1 total infusions	0.4	0.4	0.5	0.6	-0.7
Short access day 10 total infusions	0.0	0.1	0.1	0.3	-0.0
Short access total infusions	0.5	0.6	0.7	0.8	-0.7
Short access day 1 locomotion	0.7	0.7	0.8	0.8	-0.9
Short access day 10 total locomotion	2.5	2.8	3.4	1.9	-1.5
Short access total locomotion	2.4	2.5	2.6	1.5	-1.6
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.0	-0.6
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.2
One hour access (shock baseline)	0.2	0.2	0.2	-0.4	0.5
Social response proportion	0.7	0.8	1.1	0.6	-1.1
Social responses	1.5	1.9	3.1	0.9	-1.8
Social time	0.8	1.1	2.1	0.1	-1.4
Soleus weight	0.6	1.7	2.4	-1.6	1.0
Bone: stiffness	0.0	0.0	0.0	-0.0	-0.1
Tibialis anterior weight	0.1	0.4	0.5	-0.6	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.0	-0.6
Time to tail flick, vehicle, after self-admin	2.2	2.4	2.6	1.6	-1.5
Time to tail flick, test, before self-admin	4.1	4.0	5.5	1.6	-2.3
Time to tail flick, test, after self-admin	0.3	0.3	0.5	0.4	-0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	0.8	-0.5
Delta time to tail flick, test, before/after SA	0.9	0.8	1.3	-0.6	1.2
Tibia length	2.6	7.3	7.5	-2.7	2.7
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	-0.2
Ambulatory time after self-admin	3.3	3.6	4.3	-1.7	2.1
Bone: tissue strength	0.0	0.0	0.1	0.0	-0.3
Total heroin consumption	0.0	0.0	0.0	-0.2	0.2
Bone: trabecular number	0.4	0.6	0.7	0.6	-0.9
Bone: trabecular spacing	0.6	0.7	0.9	-0.9	0.8
Bone: trabecular thickness	0.9	1.1	1.3	1.2	-0.9
Bone: trabecular tissue density	0.0	0.0	0.1	0.1	-0.3
Water consumed over 24 hours	3.0	3.6	4.6	-2.1	1.6
Number of responses in last shaping day	0.2	0.2	0.3	-0.5	0.3