Mlf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Mlf1	0.11	0.06	3.9e-05	0.03	0.07	0.04	0.04	8.5e-03	1.4e-04	5.2e-03	3.7e-03
2	PL	gene expression	Mlf1	0.12	0.06	2.2e-16	0.14	0.13	0.13	0.13	8.9e-15	3.2e-14	4.3e-14	1.5e-14
3	IL	gene expression	Mlf1	0.38	0.15	1.8e-06	0.21	0.19	0.18	0.18	8.5e-06	3.0e-05	3.6e-05	3.2e-05
4	Adipose	gene expression	Mlf1	0.02	0.02	6.1e-03	0.01	0.01	0	0	5.8e-02	1.7e-02	3.6e-01	7.6e-02
5	pVTA	alternative TSS	NM_001107680.1	0.09	0.06	3.8e-03	0.01	0.04	0.02	0.01	7.3e-02	1.0e-02	5.3e-02	1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	9.8	16.4	26.5	-5.1	4.4	4.4	3.2	-2.5
Area under the delay curve	0.1	0.1	0.2	-0.5	0.3	0.3	0.3	-0.4
BMI with tail	0.1	0.3	0.5	-0.4	-0.7	-0.5	-0.7	-0.3
BMI without tail	0.4	0.9	1.3	-1.1	0.7	0.8	0.8	-1.2
Body weight	0.1	0.5	1.0	-0.2	-0.9	-0.7	-1.0	0.3
Weight adjusted by age	0.7	0.8	1.6	-1.3	0.9	0.9	0.5	-0.5
Bone surface	2.9	5.2	13.6	-3.7	2.4	2.2	1.1	-0.7
Bone volume	5.4	9.2	19.4	-4.4	3.3	3.2	2.0	-1.3
Breakpoint value in progressive ratio session	0.6	0.7	1.3	0.8	-0.6	-0.4	-0.9	1.1
Number of licking bursts	1.2	1.4	4.4	-2.1	1.1	1.0	0.5	-0.4
Context. condit. distance diff. score	4.6	5.6	7.1	-2.2	2.7	2.4	2.4	-2.1
Locomotion velocity, session 1	0.0	0.0	0.1	0.3	0.1	-0.3	0.2	-0.1
Locomotion distance, session 1	1.7	2.1	2.6	1.2	-1.3	-1.6	-1.5	1.6
Locomotion velocity, session 2	0.2	0.2	0.7	-0.2	-0.1	-0.3	-0.4	0.8
Locomotion distance, session 2	3.4	4.8	5.8	1.8	-2.1	-2.2	-2.3	2.4
Locomotion velocity, session 3	0.3	0.3	1.0	-1.0	0.2	0.2	-0.5	0.5
Locomotion distance, session 3	2.2	2.4	4.2	-2.0	1.7	1.7	1.1	-0.8
Stereotopy head waving bouts, day 3	0.7	0.8	1.8	-1.4	0.9	0.8	0.6	-0.3
Stereotopy head waving duration, day 3	0.7	0.9	2.2	-1.5	1.0	1.0	0.5	-0.1
Locomotion velocity, session 7	1.0	1.1	1.8	1.4	-0.9	-1.0	-0.9	1.0
Locomotion distance, session 7	0.3	0.3	0.6	0.7	0.4	0.2	0.8	-0.7
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	-0.0	-0.6	-0.6	-1.0	1.2
Stereotopy head waving duration, day 7	1.5	1.9	3.3	0.1	-1.3	-1.2	-1.8	1.7
Locomotion velocity, session 8	0.2	0.2	0.4	0.1	-0.5	-0.6	-0.6	0.4
Locomotion distance, session 8	0.3	0.4	0.6	0.6	-0.4	-0.7	-0.6	0.8
Degree of sensitization distance	2.2	2.2	6.6	2.6	-1.4	-1.5	-0.5	0.2
Degree of sensitization stereotypy	1.3	1.4	2.0	0.7	-1.2	-1.2	-1.4	1.4
Conditioned locomotion	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.4	0.3
Cocaine response after cond. corrected	0.4	0.5	1.0	1.0	-0.3	-0.1	0.6	-1.0
Cocaine response after cond. not corrected	0.4	0.4	1.1	1.1	-0.8	-0.5	-0.1	-0.4
Cocaine response before conditioning	0.2	0.2	0.8	-0.9	0.4	0.3	-0.3	0.2
Saline control response	0.4	0.5	2.1	-1.4	0.3	0.3	-0.6	0.3
Bone: connectivity density	6.1	9.6	15.6	-3.9	3.4	3.3	2.4	-2.1
Bone: cortical apparent density	3.4	4.5	7.8	-0.3	1.9	2.2	2.8	-2.4
Bone: cortical area	1.2	1.8	6.7	-2.6	1.2	0.9	0.2	-0.0
Bone: cortical porosity	4.4	4.8	6.1	1.8	-2.5	-2.3	-2.3	2.0
Bone: cortical porosity	3.4	3.7	4.9	1.1	-2.1	-1.9	-2.2	2.0
Bone: cortical thickness	1.3	2.1	5.0	-2.2	1.5	1.4	0.9	-0.6
Bone: cortical thickness	3.3	3.8	9.1	-3.0	1.9	2.1	1.1	-1.0
Bone: cortical tissue density	3.5	4.5	7.9	-0.3	1.9	2.2	2.8	-2.5
Condit. Reinf. active minus inactive responses	3.1	3.5	4.6	1.5	-2.1	-2.1	-2.0	1.5
Condit. Reinf. active-inactive response ratio	4.0	4.3	5.3	1.6	-2.3	-2.2	-2.3	2.0
Condit. Reinf. active responses	4.3	5.3	7.1	1.9	-2.6	-2.7	-2.4	1.7
Condit. Reinf. inactive responses	0.4	0.5	0.8	0.9	-0.8	-0.8	-0.4	-0.3
Incentive salience index mean	3.2	3.9	5.1	1.9	-2.2	-2.3	-1.9	1.5
Condit. Reinf. lever presses	2.2	2.9	4.2	2.0	-1.7	-2.0	-1.4	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.6	0.0	0.2	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.8	-0.4	0.7	0.9	0.8	-1.3
Condit. Reinf. active responses	0.3	0.4	0.8	-0.5	-0.5	-0.4	-0.9	0.9
Condit. Reinf. inactive responses	0.9	1.1	2.6	-0.2	-0.8	-0.8	-1.3	1.6
Condit. Reinf. lever presses	2.5	3.4	5.2	1.3	-2.1	-2.3	-2.0	1.4
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.5	-0.4	-0.4	-0.9	0.9
Conditioned reinforcement - actives	0.1	0.1	0.4	0.6	0.1	0.1	0.0	-0.0
Conditioned reinforcement - inactives	1.1	1.2	1.6	1.3	-1.2	-1.2	-1.0	0.7
Conditioned locomotion	0.5	0.6	1.5	-0.1	1.2	1.2	0.2	0.4
Patch foraging indifference point 0 sec	1.4	2.2	4.0	-1.5	1.8	2.0	1.1	-0.5
Patch foraging indifference point AUC	1.0	1.2	1.6	1.3	-1.0	-1.0	-1.1	1.1
Delay disc. indifference point, 0s delay	0.8	0.8	1.5	-1.2	1.0	1.0	-0.1	0.7
Delay disc. indifference point, 16s delay	0.6	0.6	2.1	0.2	-0.2	-0.3	0.8	-1.5
Delay disc. indifference point, 2s delay	0.7	0.7	1.3	-0.9	0.7	0.8	-0.6	1.2
Delay disc. indifference point, 24s delay	0.4	0.4	1.2	0.4	-0.4	-0.4	0.6	-1.1
Delay disc. indifference point, 4s delay	0.4	0.5	1.6	-1.3	0.6	0.6	-0.1	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.1	0.2	-0.0	0.1
Indifference point function ln k	0.3	0.4	0.9	-0.6	0.7	0.9	0.6	-0.2
Indifference point function log k	0.3	0.4	0.9	-0.6	0.7	0.9	0.6	-0.2
Patch foraging total patch changes 0 sec	1.1	1.7	3.2	-1.2	1.6	1.8	1.1	-0.5
Patch foraging total patch changes 12 sec	0.6	0.8	0.9	-0.7	0.9	1.0	1.0	-0.9
Patch foraging total patch changes 18 sec	0.7	0.9	1.5	-1.0	1.2	1.0	0.7	-0.6
Patch foraging total patch changes 24 sec	0.5	0.6	1.3	-0.9	1.1	0.9	0.4	-0.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	-0.5	0.7	0.8	-0.0	0.3
Patch foraging time to switch 0 sec	1.3	2.0	4.6	-1.2	1.0	0.7	1.6	-2.1
Patch foraging water rate 0 sec	0.4	0.7	1.1	0.9	-0.6	-0.4	-1.0	1.0
Patch foraging water rate 12 sec	0.7	1.0	1.9	-1.4	1.1	1.2	0.8	-0.4
Patch foraging water rate 18 sec	0.4	0.5	1.5	0.6	-0.2	-0.1	-0.9	1.2
Patch foraging water rate 24 sec	0.6	0.8	1.5	-1.0	1.2	1.1	0.6	-0.3
Patch foraging water rate 6 sec	0.4	0.7	2.2	-1.5	0.7	0.8	-0.0	0.2
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	2.8	-0.9	1.6	1.7	1.6	-1.4
Distance traveled before self-admin	0.1	0.1	0.2	0.3	0.1	0.4	0.4	-0.3
Distance traveled after self-admin	0.3	0.4	0.7	0.3	0.6	0.9	0.7	-0.3
Extensor digitorum longus weight	3.4	13.6	17.9	2.7	-3.8	-4.0	-4.2	3.5
Bone: elastic displacement	0.2	0.3	0.8	-0.9	0.4	0.2	-0.1	0.5
Bone: elastic work	1.0	1.2	4.0	-2.0	0.8	0.5	-0.5	1.1
Bone: endosteal estimation	0.2	0.5	1.0	-1.0	-0.1	-0.3	-0.9	0.7
Bone: endosteal perimeter	0.3	0.7	2.7	-1.6	0.2	-0.2	-0.7	0.5
Epididymis fat weight	1.3	3.0	5.0	-1.3	1.5	1.4	2.0	-2.2
Delta time in closed arm before/after self-admin	0.4	0.4	1.0	-1.0	0.5	0.5	0.4	-0.4
Delta time in open arm before/after self-admin	0.7	0.6	1.5	0.4	-0.6	-0.5	-1.0	1.2
Diff in mean of infusions in LGA sessions	1.0	1.1	1.9	0.5	-1.0	-0.9	-1.3	1.4
Delay discount exponential model param	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.0	0.2
Extinction: sum of active levers before priming	3.2	3.2	4.3	2.1	-1.6	-1.5	-1.8	1.9
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.3	0.4	0.3	-0.1	-0.0
Bone: final force	1.3	2.1	7.5	-2.7	1.3	1.0	-0.2	0.6
Bone: final moment	1.4	2.3	8.0	-2.8	1.4	1.1	-0.1	0.6
Food consumed during 24 hour testing period	0.2	0.3	0.4	0.6	0.4	0.3	0.6	-0.6
Glucose	0.5	0.8	1.8	-0.8	0.6	0.8	0.7	-1.3
Heart weight	0.1	0.1	0.3	-0.3	0.1	0.4	0.3	-0.5
Delay discount hyperbolic model param	0.0	0.0	0.1	0.4	-0.0	-0.1	0.2	-0.0
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.4	-0.5	-0.2	-0.1	-0.3
Intermittent access intake escalation	0.4	0.4	0.8	0.7	-0.9	-0.5	-0.4	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	-0.1	0.0	0.2	-0.4
Intermitt. access day 1 inactive lever presses	2.2	2.3	4.0	2.0	-1.6	-1.7	-1.2	0.8
Intermitt. access day 15 inactive lever presses	3.8	4.2	6.4	2.5	-2.1	-2.0	-1.8	1.7
Intermitt. access escalation Index	3.1	2.7	3.3	1.6	-1.6	-1.7	-1.5	1.8
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.7	-0.5	-0.5	-0.4	-0.0
Intermittent access day 15 total infusions	0.7	0.8	1.6	1.3	-1.0	-0.9	-0.7	0.2
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.4	1.2	-0.9	-0.7	-0.9	0.5
Intermittent access total infusions	0.8	0.9	1.4	1.2	-1.0	-0.9	-0.9	0.7
Intermittent access day 1 locomotion	0.1	0.1	0.5	0.7	-0.2	-0.2	-0.2	-0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.1	0.2	0.2	0.2	-0.6
Intermittent access total locomotion	0.1	0.1	0.3	0.5	-0.1	-0.0	-0.3	0.1
Intermittent access standard deviation	2.0	2.2	3.6	-0.1	1.3	1.5	1.8	-1.9
Left kidney weight	0.4	1.2	2.2	-1.0	1.3	1.5	0.9	-0.4
Right kidney weight	0.0	0.1	0.3	-0.2	0.5	0.3	0.3	0.2
Cocaine induced anxiety	2.1	2.4	3.5	-1.1	1.9	1.7	1.7	-1.3
Post-drug Anxiety	0.1	0.1	0.4	0.7	0.1	-0.0	0.3	-0.3
Baseline Anxiety	5.7	6.1	7.7	2.2	-2.8	-2.6	-2.6	2.0
Tail length	0.2	0.7	0.8	-0.9	0.9	0.9	0.8	-0.4
Length with tail	0.3	1.0	2.7	0.1	-0.6	-0.6	-1.2	1.6
Length without tail	1.0	2.3	4.5	0.6	-1.3	-1.2	-1.9	2.1
Times rat made contact with spout	3.1	3.6	4.5	-1.4	2.1	2.0	2.0	-1.9
Lifetime Intake	0.4	0.4	0.7	0.8	-0.7	-0.6	-0.7	0.5
Liver weight, left	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.3	-0.1
Liver weight, right	0.4	0.7	1.1	0.0	-1.0	-1.0	-1.0	0.6
Locomotor activity	0.2	0.4	0.8	0.4	-0.5	-0.0	-0.9	0.8
Locomotor testing distance	0.4	0.7	1.4	0.6	-1.0	-0.6	-1.2	0.7
Locomotor testing rearing	0.2	0.4	1.3	-1.1	0.3	0.6	-0.2	0.1
Locomotion in novel chamber	0.4	0.5	0.7	0.9	0.9	0.7	0.2	0.8
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	0.3	0.0	-0.1	-0.3	0.9
Fecal boli incidents, locomotor time 1	0.1	0.2	0.7	0.8	0.0	-0.2	0.1	-0.2
Change in fecal boli incidents, locomotor task	3.1	2.9	3.4	-1.5	1.7	1.8	1.8	-1.7
Time >=10cm from walls, locomotor time 1	1.3	1.4	2.3	-0.7	1.2	1.2	1.5	-1.0
Bouts of movement, locomotor time 1	0.6	0.6	2.5	0.0	0.1	0.2	-0.8	1.6
Total resting periods, locomotor time 1	0.5	0.6	0.9	-0.6	0.9	0.9	-0.1	0.9
Rest time, locomotor task time 1	0.8	0.9	1.7	-1.3	1.1	1.2	0.2	0.6
Distance moved, locomotor task time 1	0.8	0.8	1.5	1.2	-1.0	-1.0	0.0	-0.8
Vertical activity count, locomotor time 1	1.7	1.7	3.1	1.8	-1.6	-1.6	-0.7	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.2	0.3	0.3	0.1	0.3
Bouts of movement, locomotor time 2	1.8	2.0	3.0	1.4	-1.4	-1.2	-1.3	1.7
Total resting periods, locomotor time 2	1.4	1.5	2.6	0.9	-1.2	-1.1	-1.2	1.6
Rest time, locomotor task time 2	1.1	1.3	3.5	-1.9	1.1	1.2	0.2	0.6
Distance moved, locomotor task time 2	0.5	0.6	1.1	1.1	-0.8	-0.8	-0.0	-0.6
Vertical activity count, locomotor time 2	0.4	0.4	0.9	1.0	-0.8	-0.7	-0.0	-0.4
Light reinforcement 1	0.1	0.2	0.4	0.6	-0.5	-0.4	-0.3	-0.1
Light reinforcement 2	2.0	2.7	5.7	2.4	-1.7	-1.7	-1.1	0.8
Bone: marrow area	0.2	0.5	1.1	-1.0	0.0	-0.2	-0.9	0.7
Bone: maximum diameter	1.5	2.8	7.1	-2.7	1.7	1.4	1.0	-0.9
Bone: maximum force	0.7	1.2	4.0	-2.0	0.7	0.5	-0.7	0.9
Bone: maximum moment	0.7	1.2	3.9	-2.0	0.8	0.5	-0.6	0.9
Mean time between licks in bursts	6.1	8.5	11.3	2.7	-3.4	-3.3	-2.9	2.1
Mean num. licks in bursts	0.4	0.5	1.4	1.2	0.2	0.2	0.7	-0.8
Cd content in liver	0.1	0.1	0.4	0.6	-0.3	-0.3	0.0	0.3
Co content in liver	1.1	1.2	1.8	1.3	-1.3	-1.2	-1.0	0.6
Cu content in liver	0.3	0.4	0.7	0.3	-0.8	-0.6	-0.7	0.4
Fe content in liver	2.8	3.4	5.0	-1.6	1.6	1.7	2.0	-2.2
K content in liver	1.9	1.9	2.9	0.6	-1.4	-1.4	-1.5	1.7
Mg content in liver	2.2	2.3	3.2	1.2	-1.8	-1.8	-1.5	1.2
Mn content in liver	0.1	0.1	0.3	-0.4	0.2	0.1	0.2	-0.5
Na content in liver	0.3	0.3	0.6	-0.6	-0.2	-0.2	-0.6	0.8
Rb content in liver	0.1	0.1	0.4	0.5	-0.2	-0.1	0.1	-0.6
Se content in liver	1.2	1.5	3.3	-0.5	0.9	0.9	1.6	-1.8
Sr content in liver	0.4	0.3	0.7	-0.4	0.7	0.2	0.9	-0.5
Zn content in liver	0.2	0.2	0.5	0.7	-0.3	-0.5	0.3	-0.4
Bone: minimum diameter	0.6	1.1	2.5	-1.6	-0.2	-0.6	-1.3	1.0
Time in familiar zone, hab. session 1	2.0	1.9	2.4	-1.1	1.5	1.4	1.5	-1.3
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.2	-0.4	-0.1	-0.6	0.5
Total zone transitions, hab. session 1	1.6	2.2	3.1	1.2	-1.5	-1.8	-1.6	1.2
Total locomotion distance, hab. session 1	2.2	3.1	3.9	2.0	-1.7	-1.9	-1.6	1.4
Locomotion velocity, hab. session 1	3.5	5.0	6.8	2.6	-2.2	-2.5	-2.0	1.8
Time in familiar zone, hab. session 2	6.8	7.0	9.4	-2.5	3.1	2.9	2.7	-1.8
Time in novel zone, hab. session 2	2.8	2.8	4.0	1.2	-2.0	-1.8	-2.0	1.3
Total zone transitions, hab. session 2	1.9	2.5	2.8	1.3	-1.6	-1.7	-1.7	1.6
Total locomotion distance, hab. session 2	2.1	2.7	3.8	1.9	-1.8	-1.9	-1.5	1.1
Locomotion velocity, hab. session 2	2.9	3.8	5.2	2.3	-2.0	-2.2	-1.7	1.4
Novel to familiar place preference ratio	2.0	2.0	3.4	0.9	-1.5	-1.1	-1.6	1.8
Novelty place preference	1.8	1.9	3.6	0.7	-1.4	-1.0	-1.6	1.9
Time in novel zone, NPP test	1.5	1.5	3.5	0.4	-1.1	-0.7	-1.5	1.9
Total zone transitions, NPP test	2.9	4.2	4.4	2.1	-2.0	-2.1	-2.0	2.0
Total locomotion distance, NPP test	3.1	4.3	5.4	2.3	-2.0	-2.0	-1.9	2.1
Locomotion velocity, NPP test	3.6	5.1	7.1	2.7	-2.2	-2.2	-2.1	2.2
Intraocular pressure	0.1	0.1	0.5	0.7	-0.2	-0.1	-0.0	0.2
Delta distance traveled before/after self-admin	1.2	1.3	2.3	-0.5	1.5	1.5	1.2	-0.6
Delta ambulatory time before/after self-admin	1.7	1.9	3.4	-0.6	1.9	1.8	1.4	-0.6
Parametrial fat weight	0.3	0.5	0.7	-0.8	0.5	0.5	0.8	-0.8
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.7	0.8	1.0	0.8	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.6	0.6	0.6	0.4	-0.4
Pavlov. Cond. change in total contacts	0.7	0.7	1.8	1.3	-0.7	-1.0	0.1	-0.4
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.3	0.1	0.2	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.2	0.0	0.2	-0.2
Pavlov. Cond. lever contacts	0.9	1.0	1.3	0.9	-1.0	-1.1	-1.0	1.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	0.9	-0.7	-0.6	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	3.9	4.7	8.3	2.9	-2.5	-2.1	-1.7	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.1	0.3	0.1	0.3	-0.3
Pavlov. Cond. response bias	0.3	0.3	0.6	0.0	-0.4	-0.6	-0.7	0.8
Pavlov. Cond. lever latency	1.7	2.3	4.0	-1.0	1.7	2.0	1.5	-1.1
Pavlov. Cond. magazine entry latency	0.5	0.6	2.1	-1.5	0.6	0.3	-0.1	0.4
Pavlov. Cond. change in total contacts	1.2	1.6	3.4	0.5	-1.4	-1.8	-1.3	0.8
Pavlov. Cond. index score	1.0	1.3	2.1	0.1	-1.0	-1.4	-1.3	1.2
Pavlov. Cond. latency score	0.8	1.0	1.6	-0.1	-0.9	-1.3	-1.2	1.1
Pavlov. Cond. lever contacts	1.4	1.9	3.7	1.1	-1.5	-1.9	-1.2	0.9
Pavlov. Cond. magazine entry number	0.2	0.2	1.0	1.0	-0.4	-0.1	-0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	0.9	-0.4	-0.3	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	0.1	-0.9	-1.4	-1.1	1.0
Pavlov. Cond. response bias	1.0	1.3	2.6	0.5	-1.2	-1.6	-1.2	1.0
Time in closed arm before self-admin	0.2	0.3	0.7	-0.2	0.8	0.7	0.2	0.1
Time in closed arm after self-admin	0.5	0.5	0.7	-0.2	0.8	0.8	0.8	-0.7
Time in open arm before self-admin	0.2	0.3	0.5	-0.1	-0.7	-0.7	0.0	-0.5
Time in open arm after self-admin	0.3	0.4	0.5	-0.4	-0.7	-0.6	-0.6	0.7
Bone: periosteal estimation	0.5	1.0	3.9	-2.0	0.5	0.2	-0.6	0.5
Bone: periosteal perimeter	1.0	1.6	6.1	-2.5	1.2	0.8	-0.0	0.2
Bone: post-yield work	1.6	2.2	3.2	1.1	-1.4	-1.6	-1.8	1.3
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	0.4	-0.3	-0.0	-0.5	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	0.5	-0.4	-0.1	-0.5	0.5
Progressive ratio test 1 inactive lever presses	1.5	1.7	2.8	1.7	-1.2	-1.2	-1.2	1.0
Progressive ratio test 2 active lever presses	0.3	0.3	0.5	0.3	-0.7	-0.6	-0.3	-0.6
Progressive ratio test 2 breakpoint	0.3	0.3	0.6	0.1	-0.8	-0.6	-0.2	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	0.8	-0.0	0.1	-0.3	0.3
Incentive Sensitization - Responses	0.7	0.7	1.5	0.1	-1.2	-1.2	-0.5	-0.4
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	0.2	-1.1	-1.1	-0.5	-0.4
Sum of active levers in priming session hrs 5-6	1.7	1.7	4.2	2.1	-1.3	-1.2	-0.8	0.5
Progressive ratio	0.2	0.3	0.7	-0.7	0.1	0.2	0.4	-0.8
Food seeking constrained by brief footshock	0.1	0.1	0.5	-0.0	0.1	0.1	-0.3	0.7
Seeking ratio, punishment vs. effort	0.5	0.6	1.5	0.8	-0.3	-0.4	-0.8	1.2
Retroperitoneal fat weight	0.1	0.3	1.3	-0.3	-0.0	-0.0	0.4	-1.1
Reaction time number correct	3.5	5.0	6.1	-2.5	2.5	2.4	2.2	-1.5
Reaction time mean minus median	2.4	3.2	5.8	1.1	-2.4	-2.4	-1.7	0.6
Reaction time mean minus median AUC	5.3	6.8	12.2	1.8	-3.4	-3.5	-2.4	1.0
Reaction time num false alarms	1.8	2.4	5.7	-2.4	1.7	1.7	0.7	-0.5
Reaction time num false alarms AUC	1.8	2.4	6.1	-2.5	1.6	1.6	0.8	-0.6
Reaction time trials correct on left	3.5	5.0	6.1	-2.5	2.5	2.4	2.2	-1.5
Reaction time trials on left	3.3	4.8	5.9	-2.4	2.4	2.4	2.1	-1.5
Reaction time mean	1.8	2.5	4.1	1.2	-2.0	-1.9	-1.6	0.9
Reaction time mean AUC	3.1	4.2	6.2	1.6	-2.5	-2.4	-2.1	1.3
Median of all reaction times	1.2	1.7	2.7	1.0	-1.6	-1.6	-1.3	0.8
Reaction time omissions	3.5	4.7	8.6	1.8	-2.9	-2.8	-1.9	0.6
Reaction time false alarm rate	0.2	0.3	1.2	-1.1	0.3	0.3	-0.2	0.0
Reaction time premature initiation rate	0.5	0.7	1.7	-1.3	0.8	0.7	0.7	-0.4
Reaction time premature initiations	2.4	3.4	5.9	-2.4	1.9	1.8	1.7	-1.1
Std. dev. reaction times	3.0	4.2	6.9	1.0	-2.6	-2.5	-2.3	1.5
Reaction time trials completed	3.3	4.8	5.9	-2.4	2.4	2.4	2.1	-1.5
Reaction time trials AUC	3.2	4.5	5.4	-2.3	2.3	2.3	2.1	-1.4
Run reversals in cocaine runway, females	1.4	1.4	2.5	1.6	-1.1	-1.0	-1.0	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.7	0.1	0.4	-0.1	0.4
Latency to leave start box in cocaine runway	0.9	1.0	2.7	-0.2	0.6	0.8	1.2	-1.6
Latency to leave start box in cocaine runway, F	1.7	1.8	2.8	-0.7	1.3	1.4	1.5	-1.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	0.8	-0.5	-0.5	-0.0	-0.4
Std. dev. time between licks in bursts	3.4	4.1	6.3	1.3	-2.5	-2.2	-2.4	1.4
Total sessions with >9 infusions	0.1	0.2	0.4	0.6	-0.3	-0.1	-0.4	0.3
Short access day 1 total inactive lever presses	0.9	1.0	2.0	1.1	-0.3	-0.5	-1.2	1.4
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.1
Short access day 1 total infusions	0.3	0.3	1.3	1.1	-0.2	-0.2	-0.2	0.4
Short access day 10 total infusions	0.9	1.0	1.8	0.9	-0.8	-0.7	-1.1	1.3
Short access total infusions	0.4	0.5	0.7	0.5	-0.7	-0.6	-0.8	0.8
Short access day 1 locomotion	0.2	0.2	0.4	-0.4	0.7	0.5	0.2	-0.0
Short access day 10 total locomotion	1.3	1.4	2.0	-0.6	1.4	1.2	1.4	-1.2
Short access total locomotion	0.0	0.0	0.1	-0.2	0.3	0.2	0.2	-0.2
One hour access (0.3 mA shock)	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.1	-0.1
Compulsive drug intake	0.6	0.6	2.9	-1.7	0.2	0.1	0.3	-0.3
One hour access (shock baseline)	0.3	0.3	1.6	1.3	-0.2	-0.1	-0.1	-0.0
Social response proportion	0.5	0.6	1.7	0.3	-0.4	-0.4	-0.9	1.3
Social responses	0.6	0.8	2.1	-1.5	0.9	0.9	0.2	0.2
Social time	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	0.0
Soleus weight	0.4	1.1	2.1	-1.3	1.5	1.0	0.8	-0.1
Bone: stiffness	0.1	0.2	0.4	-0.5	0.1	0.1	-0.5	0.7
Tibialis anterior weight	0.3	0.9	1.5	-0.6	1.2	1.1	1.0	-0.8
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.0	-0.9	0.9	0.9	0.9	-1.0
Time to tail flick, vehicle, after self-admin	2.9	3.1	3.8	1.9	-1.9	-2.0	-1.7	1.2
Time to tail flick, test, before self-admin	0.7	0.7	1.5	1.2	-0.7	-0.7	-0.9	0.6
Time to tail flick, test, after self-admin	0.5	0.5	1.2	1.1	0.5	0.5	-0.2	0.8
Delta time to tail flick, vehicle, before/after SA	3.6	3.6	5.0	2.2	-1.8	-1.9	-1.8	1.8
Delta time to tail flick, test, before/after SA	0.7	0.7	1.0	-0.1	0.9	0.9	1.0	-0.8
Tibia length	0.4	1.2	2.3	1.0	-0.9	-0.8	-1.1	1.5
Ambulatory time before self-admin	0.1	0.1	0.2	0.1	-0.3	-0.1	0.2	-0.5
Ambulatory time after self-admin	1.3	1.4	2.4	-0.3	1.4	1.6	1.4	-0.8
Bone: tissue strength	0.5	0.5	0.8	0.9	-0.6	-0.6	-0.6	0.9
Total heroin consumption	0.2	0.2	0.7	0.0	0.3	0.2	-0.4	0.9
Bone: trabecular number	12.4	19.4	31.7	-5.6	4.8	4.9	3.4	-2.6
Bone: trabecular spacing	9.0	11.7	16.5	4.1	-3.7	-3.8	-2.8	2.5
Bone: trabecular thickness	14.8	17.7	22.1	-4.6	4.6	4.7	3.9	-3.0
Bone: trabecular tissue density	0.5	0.7	2.9	1.7	-0.6	-0.5	0.1	-0.2
Water consumed over 24 hours	2.2	2.6	4.0	-2.0	1.9	1.7	1.2	-1.0
Number of responses in last shaping day	0.6	0.6	1.6	0.4	0.3	0.4	0.9	-1.3