Hub : Genes

Misp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative polyA XM_017595044.2 0.11 0.08 6.1e-06 0.05 0.05 0.05 0.05 1.8e-06 4.1e-06 1.6e-06 4.2e-06
2 PL alternative polyA NM_001109284.1 0.1 0.07 6.2e-06 0.06 0.05 0.05 0.05 9.8e-07 4.2e-06 2.3e-06 5.5e-06
3 LHb gene expression Misp 0.42 0.2 9.8e-05 0.11 0.19 0.19 0.19 1.3e-03 3.2e-05 2.6e-05 3.4e-05
4 Brain gene expression Misp 0.43 0.19 0.0e+00 0.17 0.19 0.2 0.2 1.8e-15 2.5e-17 4.8e-18 4.9e-18
5 NAcc gene expression Misp 0.45 0.16 0.0e+00 0.22 0.27 0.28 0.27 2.8e-25 2.1e-31 4.6e-32 8.4e-32
6 Adipose gene expression Misp 0.73 0.14 0.0e+00 0.41 0.45 0.45 0.46 1.1e-48 1.7e-54 2.2e-55 6.2e-56
7 Adipose isoform ratio XM_017595045.2 0.03 0.03 4.5e-03 0.02 0.01 0.01 0.02 1.9e-03 7.8e-03 9.1e-03 5.3e-03
8 PL gene expression Misp 0.47 0.16 0.0e+00 0.22 0.28 0.29 0.29 2.4e-23 4.2e-31 1.2e-31 1.1e-31
9 Adipose isoform ratio XM_017595043.2 0.02 0.02 9.6e-03 0 0.01 0.01 0 8.0e-02 5.6e-02 5.7e-02 9.3e-02
10 BLA gene expression Misp 0.43 0.2 2.2e-08 0.11 0.14 0.13 0.13 1.4e-06 6.2e-08 2.0e-07 2.2e-07
11 Adipose alternative TSS XM_017595044.2 0.03 0.02 2.8e-04 0.03 0.03 0.03 0.03 4.8e-04 4.2e-04 4.4e-04 3.6e-04
12 IL gene expression Misp 0.77 0.13 2.8e-10 0.24 0.27 0.3 0.28 1.9e-06 2.9e-07 4.6e-08 1.4e-07
13 OFC gene expression Misp 0.41 0.2 1.9e-03 0.04 0.13 0.13 0.12 3.5e-02 6.2e-04 4.9e-04 7.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.62.66.1-1.50.81.61.92.1-1.71.0-1.90.0-2.5-0.61.72.0
Area under the delay curve1.71.82.91.6-1.7-1.4-1.1-1.21.3-1.61.2-1.70.8-1.6-1.0-0.8
BMI with tail5.216.824.04.3-4.7-4.1-4.0-3.64.2-4.83.8-4.92.9-4.5-3.6-3.1
BMI without tail3.67.49.72.6-2.6-2.9-2.7-2.73.1-3.12.9-2.42.6-2.0-2.9-2.8
Body weight1.04.36.02.1-2.3-2.1-2.0-1.82.2-2.52.0-2.41.6-2.3-1.9-1.6
Weight adjusted by age1.82.12.91.4-1.2-1.6-1.6-1.71.6-1.31.6-0.91.7-0.4-1.5-1.6
Bone surface3.96.913.2-2.61.82.83.13.2-2.82.0-3.10.8-3.6-0.32.83.1
Bone volume3.76.312.4-2.41.72.62.93.1-2.71.9-2.90.6-3.5-0.32.62.9
Breakpoint value in progressive ratio session2.62.87.0-1.72.11.51.31.1-1.52.1-1.32.5-0.62.71.20.8
Number of licking bursts1.01.22.31.2-0.9-1.2-1.4-1.51.0-0.71.3-0.41.50.0-1.1-1.2
Context. condit. distance diff. score0.30.40.80.2-0.3-0.5-0.4-0.60.8-0.80.7-0.30.7-0.6-0.9-0.8
Locomotion velocity, session 11.71.92.9-1.41.21.51.51.6-1.51.3-1.60.9-1.70.51.31.3
Locomotion distance, session 13.54.47.4-2.61.92.42.62.7-2.11.4-2.41.0-2.6-0.11.82.1
Locomotion velocity, session 28.610.013.3-3.73.43.53.53.5-3.33.0-3.42.7-3.11.72.82.9
Locomotion distance, session 25.88.211.2-2.82.53.23.13.3-3.22.6-3.31.8-3.41.03.03.1
Locomotion velocity, session 33.64.28.7-2.32.72.01.71.5-1.92.5-1.62.9-0.82.91.41.0
Locomotion distance, session 30.10.10.30.1-0.0-0.3-0.4-0.30.4-0.30.50.00.60.0-0.5-0.5
Stereotopy head waving bouts, day 35.56.59.0-2.93.02.72.52.3-2.62.7-2.42.9-1.92.32.42.3
Stereotopy head waving duration, day 35.26.29.3-2.73.02.62.32.1-2.52.8-2.33.1-1.72.62.22.0
Locomotion velocity, session 70.30.31.1-1.01.00.50.40.2-0.20.4-0.20.90.30.7-0.2-0.2
Locomotion distance, session 71.01.32.20.8-0.7-1.2-1.2-1.31.3-1.01.3-0.51.5-0.2-1.4-1.5
Stereotopy head waving bouts, day 70.80.91.4-1.20.91.11.11.2-0.90.6-1.10.4-1.2-0.20.91.0
Stereotopy head waving duration, day 71.31.62.4-1.51.21.51.51.5-1.41.0-1.50.7-1.50.21.11.2
Locomotion velocity, session 83.13.65.4-2.32.02.32.22.2-2.01.6-2.21.3-2.10.41.61.8
Locomotion distance, session 80.91.32.3-1.51.21.31.41.4-1.00.8-1.20.8-1.20.20.80.9
Degree of sensitization distance0.20.20.50.3-0.5-0.5-0.4-0.50.5-0.60.4-0.60.4-0.7-0.6-0.4
Degree of sensitization stereotypy0.50.52.50.5-0.9-0.4-0.4-0.10.5-1.00.3-1.3-0.1-1.6-0.4-0.1
Conditioned locomotion2.93.44.21.8-1.7-2.0-2.1-1.92.0-1.92.0-1.52.0-1.0-1.9-1.9
Cocaine response after cond. corrected9.510.712.63.6-3.4-3.5-3.4-3.43.5-3.43.4-2.93.1-2.1-3.2-3.2
Cocaine response after cond. not corrected10.111.113.03.5-3.4-3.6-3.5-3.43.6-3.43.5-2.93.2-2.2-3.3-3.3
Cocaine response before conditioning0.60.71.1-1.11.10.90.81.0-0.80.8-0.80.9-0.50.70.60.6
Saline control response0.10.10.20.3-0.3-0.3-0.4-0.20.3-0.30.3-0.30.3-0.2-0.1-0.1
Bone: connectivity density0.71.13.1-0.90.30.91.31.4-0.90.3-1.2-0.4-1.8-0.91.11.3
Bone: cortical apparent density0.81.12.61.6-1.5-1.1-1.1-1.10.8-0.90.8-1.30.5-0.9-0.6-0.5
Bone: cortical area0.10.21.4-0.0-0.3-0.00.00.10.1-0.5-0.1-0.8-0.4-1.2-0.10.2
Bone: cortical porosity1.11.21.7-1.21.11.21.21.3-1.21.0-1.20.8-1.10.51.11.2
Bone: cortical porosity1.11.21.9-1.20.81.21.21.4-1.10.7-1.30.3-1.4-0.31.11.3
Bone: cortical thickness0.40.72.30.7-1.0-0.6-0.6-0.40.6-1.00.5-1.40.1-1.5-0.5-0.2
Bone: cortical thickness0.80.91.71.1-0.8-1.1-1.2-1.21.0-0.61.1-0.31.30.2-0.9-1.0
Bone: cortical tissue density0.60.82.21.5-1.3-1.0-1.0-1.00.6-0.70.7-1.10.5-0.7-0.5-0.5
Condit. Reinf. active minus inactive responses3.33.76.4-2.22.42.01.81.7-1.82.2-1.72.5-1.22.21.61.3
Condit. Reinf. active-inactive response ratio0.60.72.9-0.61.00.50.40.3-0.61.1-0.41.4-0.01.70.50.1
Condit. Reinf. active responses5.56.79.1-3.02.92.82.72.7-2.72.7-2.72.6-2.32.02.42.3
Condit. Reinf. inactive responses3.74.46.1-2.52.12.42.32.4-2.21.8-2.41.4-2.30.72.02.2
Incentive salience index mean3.64.36.4-2.52.42.32.22.2-2.12.1-2.12.1-1.81.51.91.8
Condit. Reinf. lever presses2.43.35.7-2.01.42.02.12.3-1.81.1-2.10.5-2.4-0.31.82.1
Condit. Reinf. active minus inactive responses0.50.63.5-0.30.80.3-0.0-0.1-0.51.1-0.21.30.51.90.2-0.1
Condit. Reinf. active-inactive response ratio0.70.81.41.2-0.8-1.0-1.1-1.20.7-0.30.9-0.31.10.5-0.7-0.9
Condit. Reinf. active responses0.60.83.3-0.61.00.60.30.2-0.81.3-0.51.40.11.80.50.2
Condit. Reinf. inactive responses0.50.61.5-0.81.00.70.50.4-0.71.0-0.51.2-0.11.20.50.4
Condit. Reinf. lever presses0.60.93.7-0.81.20.60.40.4-0.61.2-0.41.50.11.90.50.1
Condit. Reinf. lever reinforcers received0.30.42.7-0.20.60.1-0.1-0.2-0.30.9-0.01.10.61.60.1-0.2
Conditioned reinforcement - actives1.61.63.0-1.71.61.31.21.3-1.11.4-1.11.5-0.91.40.90.7
Conditioned reinforcement - inactives0.80.91.40.7-0.8-1.0-0.8-0.71.2-1.11.1-0.80.9-0.5-1.1-1.1
Conditioned locomotion4.85.88.9-2.93.02.32.32.1-2.22.8-2.13.0-1.62.91.91.6
Patch foraging indifference point 0 sec0.00.10.40.1-0.3-0.1-0.10.00.1-0.30.1-0.5-0.2-0.6-0.00.1
Patch foraging indifference point AUC0.40.40.9-0.60.70.60.50.5-0.60.8-0.50.9-0.30.90.60.4
Delay disc. indifference point, 0s delay1.81.910.11.0-1.7-0.6-0.20.10.6-1.70.2-2.5-0.8-3.2-0.20.3
Delay disc. indifference point, 16s delay0.10.10.40.6-0.6-0.4-0.3-0.50.3-0.30.3-0.40.2-0.3-0.2-0.2
Delay disc. indifference point, 2s delay2.42.77.41.6-2.1-1.4-1.2-0.91.4-2.11.2-2.50.5-2.7-1.1-0.7
Delay disc. indifference point, 24s delay1.21.11.81.3-1.3-1.2-1.1-1.11.0-1.11.0-1.10.8-0.8-0.9-0.8
Delay disc. indifference point, 4s delay0.40.41.10.7-0.8-0.6-0.4-0.40.5-0.80.4-0.90.1-1.0-0.4-0.2
Delay disc. indifference point, 8s delay2.12.22.71.6-1.6-1.6-1.4-1.51.6-1.61.5-1.31.4-1.1-1.5-1.4
Indifference point function ln k0.40.60.70.8-0.8-0.8-0.8-0.70.9-0.80.8-0.70.8-0.5-0.8-0.8
Indifference point function log k0.40.60.70.8-0.8-0.8-0.8-0.70.9-0.80.8-0.70.8-0.5-0.8-0.8
Patch foraging total patch changes 0 sec0.00.10.20.2-0.3-0.2-0.2-0.10.2-0.30.2-0.40.0-0.5-0.1-0.0
Patch foraging total patch changes 12 sec0.60.71.00.7-0.8-0.9-0.9-0.81.0-0.91.0-0.80.8-0.6-0.9-0.9
Patch foraging total patch changes 18 sec0.71.01.4-1.01.11.00.80.9-1.01.2-0.91.2-0.61.10.90.8
Patch foraging total patch changes 24 sec0.10.10.2-0.20.20.30.30.4-0.40.4-0.40.2-0.40.20.50.4
Patch foraging total patch changes 6 sec0.20.30.5-0.40.40.60.40.4-0.70.7-0.60.4-0.60.40.70.6
Patch foraging time to switch 0 sec0.60.92.7-0.80.10.81.01.1-0.6-0.2-0.9-0.7-1.5-1.60.71.1
Patch foraging water rate 0 sec1.72.85.71.6-1.1-1.8-2.0-1.91.7-1.11.9-0.42.40.3-1.8-2.0
Patch foraging water rate 12 sec3.96.07.92.8-2.4-2.7-2.7-2.72.6-2.22.7-1.72.8-0.8-2.5-2.6
Patch foraging water rate 18 sec3.54.89.62.1-1.4-2.3-2.6-2.72.2-1.32.5-0.43.10.8-2.3-2.7
Patch foraging water rate 24 sec4.66.410.92.6-2.0-2.8-3.0-2.92.7-2.02.9-1.13.3-0.0-2.6-2.9
Patch foraging water rate 6 sec1.11.73.91.3-0.7-1.4-1.5-1.51.2-0.51.40.12.00.9-1.3-1.6
Seeking ratio, delayed vs. immediate footshock3.54.15.8-1.92.22.11.91.8-2.22.4-1.92.3-1.52.12.01.8
Distance traveled before self-admin0.20.20.80.4-0.5-0.2-0.1-0.20.2-0.50.1-0.8-0.2-0.9-0.20.0
Distance traveled after self-admin0.60.70.9-0.90.90.90.90.8-0.90.9-0.90.8-0.70.60.80.7
Extensor digitorum longus weight4.618.224.14.2-4.5-4.4-4.2-4.14.6-4.94.3-4.53.7-4.1-4.2-3.8
Bone: elastic displacement0.20.20.4-0.10.20.30.30.4-0.60.6-0.50.3-0.40.50.50.5
Bone: elastic work0.20.20.50.6-0.7-0.4-0.4-0.30.3-0.50.2-0.70.1-0.7-0.2-0.1
Bone: endosteal estimation0.10.10.50.2-0.3-0.2-0.3-0.40.2-0.40.2-0.50.2-0.7-0.4-0.2
Bone: endosteal perimeter0.51.01.9-1.41.21.11.11.0-1.00.9-1.10.9-1.00.50.80.8
Epididymis fat weight0.10.30.9-0.60.70.40.40.4-0.40.7-0.30.8-0.20.90.40.2
Delta time in closed arm before/after self-admin4.94.76.92.3-1.9-2.3-2.4-2.42.3-1.82.4-1.22.5-0.4-2.4-2.6
Delta time in open arm before/after self-admin0.40.41.40.5-0.8-0.5-0.3-0.40.5-0.80.3-1.1-0.0-1.2-0.20.0
Diff in mean of infusions in LGA sessions1.41.62.5-1.51.51.21.10.9-1.31.5-1.11.6-0.81.61.10.9
Delay discount exponential model param1.71.82.8-1.61.71.41.21.2-1.41.6-1.21.6-0.81.61.10.9
Extinction: sum of active levers before priming0.30.31.5-0.60.80.30.20.2-0.20.6-0.11.00.21.20.2-0.0
Active lever presses in extinction session 62.22.12.7-1.51.61.41.41.3-1.51.6-1.41.6-1.21.51.41.2
Bone: final force0.50.83.00.7-1.0-0.6-0.7-0.60.7-1.20.6-1.40.3-1.7-0.7-0.3
Bone: final moment0.40.72.40.7-1.0-0.6-0.6-0.60.6-1.00.5-1.30.3-1.5-0.6-0.3
Food consumed during 24 hour testing period1.11.32.61.6-1.4-1.2-1.1-1.41.0-1.11.1-1.01.0-0.8-1.0-0.9
Glucose1.42.13.11.8-1.8-1.5-1.4-1.41.4-1.61.3-1.71.0-1.5-1.0-0.9
Heart weight0.10.10.70.3-0.0-0.3-0.3-0.30.10.20.30.30.40.8-0.1-0.3
Delay discount hyperbolic model param2.22.33.6-1.71.91.51.31.3-1.51.8-1.31.9-0.91.91.21.0
Intermittent access intake day 1-15 change3.53.46.9-2.02.31.71.61.5-1.62.2-1.42.6-0.82.61.41.0
Intermittent access intake escalation2.02.07.1-1.41.91.00.90.7-1.01.7-0.72.4-0.02.70.70.3
Intermittent access intake escalation 22.62.68.7-1.72.11.21.00.9-1.22.0-0.92.6-0.12.90.90.4
Intermitt. access day 1 inactive lever presses0.30.30.70.3-0.1-0.5-0.5-0.60.6-0.30.70.10.80.5-0.7-0.8
Intermitt. access day 15 inactive lever presses0.20.20.7-0.40.60.30.30.3-0.20.5-0.20.7-0.00.80.2-0.0
Intermitt. access escalation Index0.30.20.5-0.1-0.10.40.40.5-0.50.1-0.6-0.3-0.7-0.60.60.7
Intermittent access day 1 total infusions0.00.00.1-0.0-0.1-0.10.10.10.1-0.20.1-0.2-0.2-0.20.0-0.0
Intermittent access day 15 total infusions0.70.82.6-1.01.10.60.70.7-0.51.0-0.41.4-0.21.60.50.2
Intermittent access terminal intake (last 3 days)0.50.61.1-1.01.00.60.80.9-0.50.8-0.51.0-0.41.10.60.3
Intermittent access total infusions0.10.10.3-0.30.30.10.20.3-0.00.2-0.00.4-0.00.50.1-0.1
Intermittent access day 1 locomotion0.20.20.6-0.40.50.30.40.4-0.30.5-0.20.7-0.10.80.40.2
Intermittent access day 15 total locomotion2.22.44.3-1.61.91.41.41.4-1.41.8-1.32.1-0.92.11.31.0
Intermittent access total locomotion0.80.91.2-1.01.10.91.01.0-0.81.0-0.81.1-0.71.00.90.7
Intermittent access standard deviation0.80.93.3-0.91.30.70.60.5-0.61.2-0.51.60.01.80.50.2
Left kidney weight0.10.41.1-0.20.30.60.50.6-0.80.5-0.70.3-0.7-0.00.91.0
Right kidney weight0.92.54.1-1.41.81.61.41.2-1.72.0-1.52.0-1.01.81.41.3
Cocaine induced anxiety1.82.13.0-1.41.21.61.61.7-1.61.3-1.70.9-1.70.41.61.7
Post-drug Anxiety1.82.02.7-1.41.31.61.61.6-1.51.3-1.60.9-1.60.51.51.5
Baseline Anxiety0.20.20.60.20.0-0.4-0.5-0.60.4-0.00.50.30.80.6-0.5-0.7
Tail length1.54.510.1-2.52.81.91.91.6-1.82.5-1.63.2-0.83.11.30.9
Length with tail1.55.57.7-2.62.82.42.32.2-2.42.7-2.22.8-1.72.42.01.8
Length without tail0.61.42.0-1.21.01.31.21.4-1.31.0-1.40.5-1.40.01.31.4
Times rat made contact with spout1.11.32.41.5-1.1-1.3-1.3-1.61.1-0.91.3-0.61.3-0.3-1.0-1.0
Lifetime Intake0.00.00.1-0.30.30.10.20.3-0.00.1-0.10.3-0.10.30.10.0
Liver weight, left1.72.84.01.7-1.9-1.7-1.6-1.41.8-2.01.6-1.91.2-1.8-1.5-1.3
Liver weight, right0.71.13.00.9-1.2-0.9-0.8-0.61.0-1.40.8-1.50.4-1.7-0.9-0.6
Locomotor activity4.16.67.9-2.82.72.72.82.6-2.72.7-2.72.4-2.41.82.42.4
Locomotor testing distance2.13.54.1-2.02.01.92.01.9-2.02.0-1.91.8-1.71.51.81.7
Locomotor testing rearing0.20.30.70.5-0.3-0.6-0.6-0.60.6-0.30.6-0.00.80.3-0.5-0.6
Locomotion in novel chamber0.10.10.40.5-0.1-0.2-0.4-0.6-0.10.20.20.30.50.5-0.1-0.1
Locomotion in novel chamber post-restriction0.30.31.3-0.50.80.30.20.1-0.30.6-0.21.00.31.10.1-0.1
Fecal boli incidents, locomotor time 11.51.72.51.3-1.4-1.3-1.1-1.11.4-1.61.2-1.41.0-1.4-1.3-1.1
Change in fecal boli incidents, locomotor task0.10.10.2-0.30.40.40.40.3-0.40.4-0.40.4-0.30.20.40.4
Time >=10cm from walls, locomotor time 10.30.31.40.1-0.40.10.30.3-0.2-0.4-0.3-0.8-0.8-1.20.30.6
Bouts of movement, locomotor time 10.10.10.3-0.10.30.10.1-0.1-0.00.20.00.50.30.4-0.0-0.1
Total resting periods, locomotor time 10.10.10.4-0.30.50.30.30.1-0.20.4-0.20.70.00.50.20.1
Rest time, locomotor task time 10.50.61.0-0.91.00.90.90.7-0.70.7-0.71.0-0.50.50.50.6
Distance moved, locomotor task time 10.20.31.10.2-0.60.00.10.2-0.1-0.3-0.2-0.9-0.8-1.10.30.5
Vertical activity count, locomotor time 11.11.11.81.3-1.2-1.2-1.3-1.31.0-0.91.1-0.91.0-0.3-0.9-1.0
Time >=10cm from walls, locomotor time 22.12.22.81.6-1.6-1.6-1.4-1.51.6-1.71.5-1.51.2-1.4-1.4-1.3
Bouts of movement, locomotor time 21.81.92.7-1.31.11.51.51.4-1.51.3-1.50.9-1.60.51.61.7
Total resting periods, locomotor time 21.81.92.8-1.31.11.51.61.4-1.51.3-1.50.9-1.70.51.61.7
Rest time, locomotor task time 21.01.11.5-1.01.01.11.21.0-1.21.1-1.11.0-1.10.61.21.2
Distance moved, locomotor task time 20.81.01.30.8-0.9-1.0-1.0-0.81.1-1.11.0-1.00.9-0.8-1.1-1.1
Vertical activity count, locomotor time 21.92.13.01.2-1.2-1.5-1.5-1.41.6-1.51.6-1.11.6-0.7-1.7-1.7
Light reinforcement 16.111.113.9-3.63.73.43.43.3-3.43.7-3.33.6-2.83.23.02.7
Light reinforcement 22.53.44.6-2.12.01.91.91.8-1.92.0-1.81.8-1.71.71.71.5
Bone: marrow area0.10.10.50.2-0.3-0.2-0.3-0.40.3-0.50.2-0.50.3-0.7-0.4-0.2
Bone: maximum diameter1.32.53.6-1.91.71.71.71.6-1.71.5-1.71.3-1.60.81.41.4
Bone: maximum force0.71.22.91.0-1.2-0.9-1.0-0.91.0-1.40.9-1.50.7-1.7-1.0-0.7
Bone: maximum moment0.61.02.40.9-1.1-0.8-0.9-0.80.9-1.20.8-1.30.6-1.5-0.9-0.6
Mean time between licks in bursts2.12.96.4-1.82.21.61.21.1-1.62.2-1.32.4-0.72.51.31.0
Mean num. licks in bursts0.00.00.10.0-0.10.10.30.2-0.1-0.0-0.2-0.1-0.3-0.20.20.2
Cd content in liver0.10.10.40.3-0.5-0.3-0.3-0.10.2-0.40.2-0.60.1-0.5-0.1-0.0
Co content in liver0.30.40.8-0.90.90.60.40.5-0.40.6-0.40.8-0.10.90.30.2
Cu content in liver0.30.40.9-0.60.30.70.80.8-0.60.2-0.7-0.1-0.9-0.60.60.8
Fe content in liver0.10.10.5-0.70.60.1-0.00.10.3-0.10.20.40.50.3-0.4-0.4
K content in liver1.11.12.5-1.61.11.31.21.3-1.00.6-1.10.4-1.2-0.30.81.1
Mg content in liver1.01.01.7-1.30.91.21.11.2-1.00.5-1.10.2-1.2-0.40.91.1
Mn content in liver4.55.28.2-2.92.32.62.62.6-2.31.8-2.51.5-2.50.52.02.3
Na content in liver0.50.51.5-1.10.40.70.60.9-0.2-0.3-0.5-0.5-0.8-1.20.10.5
Rb content in liver0.30.41.0-0.50.10.60.70.7-0.5-0.0-0.7-0.4-1.0-0.90.50.8
Se content in liver0.50.61.4-1.21.10.80.90.9-0.60.6-0.70.9-0.50.40.40.5
Sr content in liver0.50.51.10.6-0.4-0.8-0.8-0.90.7-0.40.8-0.11.00.3-0.8-0.9
Zn content in liver0.60.63.20.30.3-0.4-0.6-0.70.20.50.61.01.11.8-0.3-0.8
Bone: minimum diameter0.10.10.4-0.70.50.50.30.4-0.30.1-0.40.1-0.3-0.30.10.3
Time in familiar zone, hab. session 10.70.72.8-0.71.00.50.50.3-0.51.1-0.41.40.01.70.40.0
Time in novel zone, hab. session 10.30.31.70.2-0.6-0.0-0.00.10.1-0.6-0.1-1.0-0.4-1.30.10.4
Total zone transitions, hab. session 13.24.55.9-2.22.02.42.22.4-2.31.9-2.31.5-2.30.82.22.3
Total locomotion distance, hab. session 14.86.89.5-3.02.53.02.93.1-2.82.2-2.91.8-2.80.72.62.8
Locomotion velocity, hab. session 15.37.59.8-3.12.73.12.93.1-2.92.4-3.02.1-2.81.02.72.9
Time in familiar zone, hab. session 22.12.27.8-1.01.71.01.10.7-1.11.9-0.82.5-0.32.81.30.8
Time in novel zone, hab. session 21.91.95.81.5-1.8-1.0-0.9-0.91.0-1.70.8-2.20.2-2.4-1.1-0.7
Total zone transitions, hab. session 22.22.86.3-1.20.81.82.02.0-1.91.0-2.00.2-2.5-0.71.82.2
Total locomotion distance, hab. session 23.64.86.7-1.91.82.42.62.4-2.52.0-2.51.6-2.60.82.32.3
Locomotion velocity, hab. session 24.56.19.1-2.12.02.72.92.7-2.82.2-2.81.6-3.00.72.62.8
Novel to familiar place preference ratio1.21.35.90.9-1.4-0.6-0.5-0.20.7-1.50.4-2.0-0.3-2.4-0.40.0
Novelty place preference0.70.73.70.6-1.0-0.3-0.10.00.4-1.10.1-1.5-0.5-1.9-0.10.2
Time in novel zone, NPP test0.90.94.20.8-1.2-0.5-0.3-0.20.6-1.30.3-1.6-0.3-2.0-0.40.0
Total zone transitions, NPP test1.52.14.2-1.20.91.61.61.8-1.61.0-1.70.4-2.0-0.21.71.9
Total locomotion distance, NPP test1.42.03.5-1.51.01.61.61.8-1.40.8-1.60.4-1.9-0.41.41.7
Locomotion velocity, NPP test1.82.54.2-1.61.21.81.82.0-1.71.1-1.80.6-2.1-0.11.71.9
Intraocular pressure1.21.72.71.6-1.1-1.6-1.5-1.61.3-0.71.5-0.41.70.4-1.1-1.4
Delta distance traveled before/after self-admin1.41.52.3-1.41.51.21.11.1-1.11.4-1.11.5-0.71.41.00.9
Delta ambulatory time before/after self-admin1.71.92.7-1.61.61.41.41.4-1.31.5-1.31.6-0.91.41.21.1
Parametrial fat weight0.10.20.7-0.30.50.20.20.2-0.20.4-0.10.80.20.80.0-0.2
Pavlov. Cond. lever latency0.91.22.31.5-1.1-1.3-1.4-1.51.0-0.51.2-0.51.30.3-0.8-1.0
Pavlov. Cond. magazine entry latency2.43.15.8-2.32.41.81.71.5-1.51.9-1.42.4-0.92.11.20.9
Pavlov. Cond. change in total contacts0.40.41.2-1.10.90.80.80.7-0.50.4-0.60.7-0.40.20.20.3
Pavlov. Cond. index score1.51.93.9-2.01.71.61.61.6-1.21.1-1.31.3-1.20.61.01.1
Pavlov. Cond. latency score2.02.65.1-2.31.91.91.91.9-1.51.2-1.61.4-1.50.51.21.4
Pavlov. Cond. lever contacts1.61.93.2-1.81.31.61.71.8-1.30.8-1.50.7-1.6-0.11.21.5
Pavlov. Cond. magazine entry number1.01.22.51.6-1.5-1.2-1.1-1.00.9-1.10.9-1.40.6-1.0-0.7-0.6
Pavlov. Cond. intertrial magazine entries0.30.30.70.6-0.3-0.6-0.7-0.80.4-0.00.60.10.80.6-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.1.82.34.4-2.11.91.71.71.7-1.41.3-1.41.6-1.20.91.11.1
Pavlov. Cond. response bias1.41.73.3-1.81.81.41.31.3-1.11.3-1.11.6-0.81.20.90.8
Pavlov. Cond. lever latency0.20.20.80.4-0.6-0.4-0.2-0.30.3-0.60.2-0.7-0.0-0.9-0.3-0.1
Pavlov. Cond. magazine entry latency0.20.20.6-0.70.70.50.40.3-0.30.5-0.30.7-0.10.60.30.2
Pavlov. Cond. change in total contacts0.10.21.0-0.20.40.20.00.1-0.30.6-0.10.60.11.00.30.1
Pavlov. Cond. index score0.20.20.9-0.50.60.30.20.2-0.30.6-0.20.80.11.00.20.1
Pavlov. Cond. latency score0.20.30.7-0.50.70.50.30.4-0.50.7-0.30.8-0.10.90.40.3
Pavlov. Cond. lever contacts0.10.21.0-0.20.40.1-0.1-0.1-0.10.40.10.70.41.00.0-0.2
Pavlov. Cond. magazine entry number0.40.40.90.9-1.0-0.7-0.6-0.50.5-0.70.5-1.00.2-0.9-0.4-0.3
Pavlov. Cond. intertrial magazine entries0.91.21.71.2-1.0-1.1-1.2-1.31.1-0.91.2-0.71.2-0.4-1.1-1.1
Pavlov. Cond. lever-magazine prob. diff.0.30.30.9-0.70.80.50.40.4-0.50.7-0.40.9-0.10.90.40.2
Pavlov. Cond. response bias0.40.52.5-0.50.90.40.20.2-0.40.9-0.21.30.31.60.30.0
Time in closed arm before self-admin0.50.61.5-0.70.20.60.70.8-0.6-0.1-0.8-0.6-1.1-1.10.91.2
Time in closed arm after self-admin0.00.00.00.00.0-0.0-0.1-0.10.10.00.10.10.20.2-0.2-0.2
Time in open arm before self-admin0.20.20.8-0.10.40.30.20.3-0.30.6-0.20.80.00.90.1-0.1
Time in open arm after self-admin0.70.81.21.0-1.1-0.9-0.8-0.80.9-1.00.8-1.10.6-0.9-0.7-0.6
Bone: periosteal estimation0.10.11.1-0.2-0.20.10.10.1-0.1-0.3-0.2-0.6-0.4-1.1-0.00.3
Bone: periosteal perimeter0.40.71.3-1.20.91.01.01.0-0.80.6-1.00.4-1.0-0.10.70.8
Bone: post-yield work0.60.81.40.5-0.6-0.8-0.9-0.91.0-1.01.0-0.71.1-0.8-1.2-1.0
Progressive ratio test 1 active lever presses0.30.40.50.6-0.5-0.7-0.6-0.60.7-0.50.7-0.30.7-0.0-0.6-0.7
Progressive ratio test 1 breakpoint0.40.40.60.7-0.6-0.8-0.6-0.60.7-0.60.8-0.30.8-0.1-0.6-0.7
Progressive ratio test 1 inactive lever presses0.00.00.1-0.10.10.10.30.1-0.10.2-0.10.2-0.20.20.20.1
Progressive ratio test 2 active lever presses0.10.10.30.1-0.0-0.4-0.3-0.20.4-0.10.50.20.50.5-0.3-0.5
Progressive ratio test 2 breakpoint0.00.10.3-0.30.30.00.10.20.00.20.00.40.10.50.1-0.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.60.40.40.60.7-0.20.2-0.30.2-0.60.10.30.2
Incentive Sensitization - Responses0.10.10.30.2-0.1-0.4-0.3-0.20.4-0.20.50.10.50.4-0.3-0.5
Incentive Sensitization - Breakpoint0.10.10.20.00.0-0.3-0.2-0.10.3-0.10.30.20.40.5-0.2-0.4
Sum of active levers in priming session hrs 5-60.00.00.1-0.20.10.10.20.3-0.10.1-0.2-0.0-0.3-0.10.20.2
Progressive ratio0.10.10.20.2-0.2-0.3-0.3-0.30.4-0.40.3-0.20.4-0.3-0.5-0.4
Food seeking constrained by brief footshock0.81.01.6-1.11.11.11.31.2-1.00.9-1.01.0-1.00.40.90.9
Seeking ratio, punishment vs. effort0.60.71.0-0.80.80.91.00.9-0.90.8-0.80.7-1.00.40.90.9
Retroperitoneal fat weight0.20.81.00.9-0.9-0.9-0.9-0.90.9-1.00.9-0.80.8-0.8-0.9-0.8
Reaction time number correct2.63.85.62.2-1.7-2.1-2.2-2.32.1-1.62.2-1.12.4-0.4-2.0-2.1
Reaction time mean minus median0.10.20.9-0.40.60.20.00.0-0.20.5-0.10.80.31.00.1-0.1
Reaction time mean minus median AUC0.20.20.4-0.50.40.60.50.5-0.50.3-0.50.1-0.6-0.20.50.6
Reaction time num false alarms1.11.52.90.8-0.8-1.3-1.3-1.31.5-1.11.5-0.61.6-0.1-1.6-1.7
Reaction time num false alarms AUC1.52.13.81.0-0.9-1.5-1.6-1.51.7-1.31.7-0.71.9-0.1-1.8-1.9
Reaction time trials correct on left2.63.85.62.2-1.7-2.1-2.2-2.32.1-1.62.2-1.12.4-0.4-2.0-2.1
Reaction time trials on left2.53.65.22.1-1.7-2.1-2.1-2.32.0-1.62.1-1.12.3-0.4-1.9-2.0
Reaction time mean0.00.00.20.1-0.10.1-0.10.0-0.20.1-0.2-0.2-0.1-0.20.30.4
Reaction time mean AUC0.00.00.10.2-0.20.0-0.1-0.0-0.20.0-0.1-0.3-0.1-0.30.30.4
Median of all reaction times0.10.10.50.4-0.5-0.1-0.2-0.10.0-0.3-0.0-0.6-0.2-0.70.20.4
Reaction time omissions0.30.40.8-0.20.40.60.50.3-0.80.8-0.70.4-0.70.50.90.8
Reaction time false alarm rate0.10.10.3-0.30.0-0.2-0.2-0.10.4-0.40.3-0.20.3-0.1-0.6-0.6
Reaction time premature initiation rate0.20.31.8-0.10.50.20.0-0.0-0.40.8-0.10.90.21.30.40.1
Reaction time premature initiations0.60.92.11.0-0.4-0.9-1.2-1.20.7-0.01.00.41.51.2-0.7-1.0
Std. dev. reaction times0.00.00.2-0.10.20.2-0.1-0.0-0.20.3-0.10.30.10.40.20.1
Reaction time trials completed2.53.65.22.1-1.7-2.1-2.1-2.32.0-1.62.1-1.12.3-0.4-1.9-2.0
Reaction time trials AUC2.94.26.42.3-1.8-2.3-2.3-2.52.2-1.72.3-1.12.5-0.3-2.1-2.2
Run reversals in cocaine runway, females0.50.50.6-0.60.80.70.70.7-0.70.8-0.70.8-0.50.60.60.6
Run reversals in cocaine runway, males1.71.72.2-1.31.41.31.31.2-1.41.5-1.31.4-1.11.21.31.1
Latency to leave start box in cocaine runway1.92.13.1-1.41.21.51.51.7-1.61.3-1.70.7-1.80.51.61.6
Latency to leave start box in cocaine runway, F1.41.53.8-0.80.41.21.21.6-1.30.6-1.5-0.3-1.9-0.71.41.6
Latency to leave start box in cocaine runway, M0.70.73.5-0.81.10.40.20.1-0.41.0-0.21.50.41.90.2-0.1
Std. dev. time between licks in bursts0.60.71.0-0.91.01.00.70.7-1.01.0-0.80.9-0.60.80.80.8
Total sessions with >9 infusions0.10.10.2-0.1-0.00.10.30.3-0.1-0.0-0.2-0.1-0.4-0.30.30.3
Short access day 1 total inactive lever presses0.10.10.3-0.50.40.30.50.4-0.30.3-0.30.4-0.40.30.30.3
Short access day 10 total inactive lever presses0.00.00.10.1-0.2-0.2-0.1-0.30.3-0.20.3-0.10.2-0.0-0.3-0.3
Short access day 1 total infusions0.90.91.5-1.10.91.01.21.2-0.90.8-1.00.6-1.20.21.01.0
Short access day 10 total infusions0.10.10.20.2-0.1-0.4-0.3-0.30.4-0.20.40.10.50.4-0.3-0.5
Short access total infusions0.00.00.1-0.20.10.10.30.3-0.10.0-0.10.0-0.3-0.10.20.2
Short access day 1 locomotion1.31.41.8-1.21.21.21.41.3-1.11.2-1.21.2-1.10.91.21.1
Short access day 10 total locomotion1.61.84.6-1.51.81.21.00.9-1.21.7-1.02.0-0.42.10.90.6
Short access total locomotion0.70.71.1-1.01.00.80.90.9-0.70.9-0.71.0-0.60.80.70.6
One hour access (0.3 mA shock)0.10.10.30.1-0.3-0.4-0.4-0.20.5-0.50.4-0.40.3-0.3-0.4-0.4
Compulsive drug intake0.40.41.90.5-0.8-0.3-0.3-0.30.3-0.80.2-1.1-0.1-1.4-0.30.0
One hour access (shock baseline)0.20.20.50.1-0.0-0.5-0.5-0.30.5-0.20.60.20.70.6-0.4-0.7
Social response proportion1.61.72.4-1.11.21.41.31.3-1.61.4-1.41.0-1.30.71.51.5
Social responses6.38.110.5-3.03.23.02.82.7-3.03.2-2.83.1-2.22.72.62.4
Social time0.20.20.90.4-0.6-0.3-0.20.00.3-0.60.1-0.8-0.2-1.0-0.10.1
Soleus weight6.719.529.54.6-5.2-4.5-4.1-3.84.5-5.24.1-5.42.9-5.2-3.8-3.2
Bone: stiffness1.52.45.91.2-1.6-1.3-1.3-1.21.6-2.11.4-2.00.9-2.4-1.5-1.1
Tibialis anterior weight0.82.84.51.4-1.7-1.6-1.5-1.41.8-2.11.6-1.91.3-2.1-1.5-1.2
Time to tail flick, vehicle, before self-admin1.51.52.1-1.41.11.31.41.3-1.31.1-1.40.8-1.50.41.41.4
Time to tail flick, vehicle, after self-admin0.30.30.90.4-0.1-0.6-0.6-0.40.7-0.20.80.31.00.6-0.6-0.8
Time to tail flick, test, before self-admin1.11.11.7-0.90.71.01.11.3-1.10.8-1.10.5-1.30.21.31.3
Time to tail flick, test, after self-admin0.50.50.8-0.70.80.90.80.7-0.80.8-0.80.7-0.70.50.60.6
Delta time to tail flick, vehicle, before/after SA2.22.13.51.4-1.1-1.5-1.5-1.41.7-1.31.7-0.71.8-0.2-1.7-1.9
Delta time to tail flick, test, before/after SA0.20.20.50.00.2-0.2-0.3-0.50.30.00.40.40.70.6-0.6-0.7
Tibia length0.41.32.8-1.11.41.00.90.8-1.11.4-0.91.6-0.51.70.80.7
Ambulatory time before self-admin0.20.20.70.4-0.6-0.3-0.2-0.30.2-0.50.2-0.8-0.1-0.8-0.3-0.2
Ambulatory time after self-admin0.40.40.5-0.70.70.70.70.6-0.70.7-0.70.6-0.60.40.70.7
Bone: tissue strength0.70.72.00.9-1.1-0.7-0.6-0.50.6-1.00.5-1.40.2-1.4-0.5-0.3
Total heroin consumption1.51.82.5-1.41.51.31.31.2-1.31.6-1.21.6-1.01.51.21.0
Bone: trabecular number2.13.34.9-2.01.71.92.12.2-1.81.6-2.01.2-2.10.61.81.8
Bone: trabecular spacing4.15.38.82.4-1.9-2.5-2.7-2.82.4-1.82.6-1.13.0-0.2-2.4-2.6
Bone: trabecular thickness4.04.710.5-1.91.22.22.52.7-2.31.4-2.60.1-3.2-0.82.42.7
Bone: trabecular tissue density1.62.22.71.6-1.6-1.5-1.6-1.51.5-1.61.5-1.51.4-1.4-1.4-1.2
Water consumed over 24 hours0.20.21.00.6-0.7-0.3-0.2-0.40.2-0.50.1-0.8-0.1-1.0-0.20.0
Number of responses in last shaping day0.10.10.3-0.60.40.20.40.4-0.10.2-0.10.3-0.20.40.10.0