Hub : Genes

Miox

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Miox	0.76	0.06	0.0e+00	0.43	0.52	0.53	0.53	1.3e-51	1.1e-67	3.5e-69	8.7e-69
2	Liver	intron excision ratio	chr7_122285231_122285467	0.1	0.06	2.6e-07	0.05	0.06	0.06	0.07	4.2e-06	9.3e-07	9.1e-08	8.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.4	0.7	1.0	-0.7	1.0
Area under the delay curve	0.7	0.8	1.5	0.4	-1.2
BMI with tail	3.2	11.2	15.3	3.9	-2.7
BMI without tail	0.6	1.7	3.1	1.8	-0.5
Body weight	1.2	5.3	7.5	2.7	-1.8
Weight adjusted by age	2.5	3.8	5.0	2.2	-1.6
Bone surface	0.0	0.1	0.1	0.3	-0.3
Bone volume	0.0	0.1	0.1	-0.3	0.2
Breakpoint value in progressive ratio session	0.4	0.5	0.7	0.8	-0.6
Number of licking bursts	0.0	0.0	0.0	-0.2	-0.1
Context. condit. distance diff. score	0.2	0.2	0.5	0.7	-0.0
Locomotion velocity, session 1	0.3	0.3	0.4	0.6	-0.5
Locomotion distance, session 1	0.3	0.4	0.8	-0.9	0.0
Locomotion velocity, session 2	0.8	0.9	1.5	1.2	-0.6
Locomotion distance, session 2	0.1	0.2	0.3	-0.6	-0.2
Locomotion velocity, session 3	1.5	1.7	2.4	-1.0	1.5
Locomotion distance, session 3	0.3	0.3	0.4	-0.6	0.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	-0.6	-0.1
Stereotopy head waving duration, day 3	0.5	0.6	0.7	-0.8	0.7
Locomotion velocity, session 7	0.1	0.2	0.2	-0.3	0.4
Locomotion distance, session 7	0.0	0.0	0.0	-0.2	0.0
Stereotopy head waving bouts, day 7	1.0	1.1	1.7	-0.7	1.3
Stereotopy head waving duration, day 7	1.8	2.1	2.8	-1.2	1.7
Locomotion velocity, session 8	0.3	0.4	0.5	0.6	0.7
Locomotion distance, session 8	0.7	1.0	1.3	1.1	-0.8
Degree of sensitization distance	1.9	1.9	2.2	1.5	-1.3
Degree of sensitization stereotypy	1.1	1.2	1.9	-0.7	1.4
Conditioned locomotion	0.1	0.2	0.2	0.4	-0.4
Cocaine response after cond. corrected	0.3	0.4	0.8	0.9	-0.1
Cocaine response after cond. not corrected	0.7	0.9	1.7	1.3	-0.2
Cocaine response before conditioning	0.5	0.6	0.9	1.0	-0.5
Saline control response	2.5	3.4	3.5	1.9	-1.8
Bone: connectivity density	0.6	0.9	1.4	-0.6	1.2
Bone: cortical apparent density	1.3	1.8	3.2	-1.8	0.6
Bone: cortical area	3.8	5.9	8.2	1.9	-2.9
Bone: cortical porosity	2.7	2.9	3.2	1.6	-1.8
Bone: cortical porosity	3.7	4.0	4.4	2.1	-1.9
Bone: cortical thickness	0.9	1.5	2.7	0.5	-1.7
Bone: cortical thickness	0.1	0.1	0.1	-0.3	0.3
Bone: cortical tissue density	1.2	1.7	2.9	-1.7	0.7
Condit. Reinf. active minus inactive responses	2.9	3.2	3.4	1.8	-1.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	0.6	-0.6
Condit. Reinf. active responses	3.6	4.5	4.8	2.2	-2.0
Condit. Reinf. inactive responses	2.1	2.5	3.0	1.7	-1.4
Incentive salience index mean	5.0	6.1	6.1	2.5	-2.5
Condit. Reinf. lever presses	4.1	5.8	6.1	2.3	-2.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	0.6	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.4
Condit. Reinf. active responses	1.4	2.0	2.1	1.4	-1.4
Condit. Reinf. inactive responses	1.3	1.7	1.8	1.3	-1.2
Condit. Reinf. lever presses	2.6	3.6	4.0	2.0	-1.8
Condit. Reinf. lever reinforcers received	1.5	2.1	2.3	1.4	-1.5
Conditioned reinforcement - actives	0.7	1.2	1.7	1.3	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.2	0.4
Conditioned locomotion	1.4	1.8	2.9	1.7	-0.8
Patch foraging indifference point 0 sec	0.3	0.5	0.7	0.8	-0.5
Patch foraging indifference point AUC	1.1	1.6	1.8	1.2	-1.3
Delay disc. indifference point, 0s delay	6.5	7.1	8.7	2.3	-3.0
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	0.5	-0.8
Delay disc. indifference point, 2s delay	2.8	3.1	5.2	1.0	-2.3
Delay disc. indifference point, 24s delay	0.3	0.4	0.4	0.6	-0.6
Delay disc. indifference point, 4s delay	1.1	1.2	2.3	0.3	-1.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.6	-0.2
Indifference point function ln k	0.2	0.3	0.5	0.7	-0.2
Indifference point function log k	0.2	0.3	0.5	0.7	-0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.5	-0.2
Patch foraging total patch changes 12 sec	1.7	2.2	2.4	1.4	-1.6
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.1	0.2
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.2	0.3
Patch foraging total patch changes 6 sec	0.8	1.1	1.2	1.1	-1.0
Patch foraging time to switch 0 sec	0.2	0.4	0.7	-0.8	0.5
Patch foraging water rate 0 sec	0.1	0.1	0.2	0.5	0.0
Patch foraging water rate 12 sec	0.4	0.8	1.3	1.2	-0.5
Patch foraging water rate 18 sec	0.3	0.5	0.5	0.7	0.7
Patch foraging water rate 24 sec	0.3	0.5	0.9	0.1	1.0
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.4	-0.0
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	0.9	-0.9	1.0
Distance traveled before self-admin	0.5	0.6	0.7	-0.7	-0.8
Distance traveled after self-admin	0.1	0.1	0.2	-0.5	0.1
Extensor digitorum longus weight	0.1	0.3	0.5	0.7	-0.1
Bone: elastic displacement	0.2	0.2	0.4	-0.3	0.6
Bone: elastic work	0.3	0.3	0.6	0.8	-0.3
Bone: endosteal estimation	0.8	1.8	2.2	1.5	-1.1
Bone: endosteal perimeter	5.5	11.6	12.6	3.3	-3.6
Epididymis fat weight	3.2	11.1	11.6	3.4	-3.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.0	-0.3
Diff in mean of infusions in LGA sessions	2.5	3.1	4.1	2.0	-1.4
Delay discount exponential model param	0.4	0.4	0.9	-0.2	0.9
Extinction: sum of active levers before priming	0.4	0.5	0.7	0.4	-0.8
Active lever presses in extinction session 6	0.8	0.8	1.6	1.3	-0.2
Bone: final force	0.8	1.3	2.4	0.4	-1.5
Bone: final moment	0.5	0.8	1.6	0.2	-1.3
Food consumed during 24 hour testing period	0.8	1.1	1.7	1.3	-0.7
Glucose	0.1	0.2	0.2	0.4	-0.4
Heart weight	0.0	0.0	0.1	-0.1	0.3
Delay discount hyperbolic model param	0.5	0.6	1.1	-0.2	1.1
Intermittent access intake day 1-15 change	0.3	0.6	1.1	1.1	-0.3
Intermittent access intake escalation	0.4	0.8	1.3	1.2	-0.4
Intermittent access intake escalation 2	2.7	3.0	4.4	2.1	-1.3
Intermitt. access day 1 inactive lever presses	0.3	1.1	1.7	1.3	-0.7
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.8	0.6	0.9
Intermitt. access escalation Index	0.6	0.8	1.0	-1.0	0.7
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.3	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.3	0.4
Intermittent access terminal intake (last 3 days)	0.8	1.1	1.9	1.4	-0.5
Intermittent access total infusions	0.1	0.1	0.2	0.5	0.0
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.2	-0.3
Intermittent access day 15 total locomotion	0.7	1.3	1.9	1.4	-0.8
Intermittent access total locomotion	0.3	0.3	0.7	0.8	-0.2
Intermittent access standard deviation	0.1	0.3	0.5	-0.1	0.7
Left kidney weight	3.4	15.8	23.0	4.8	-2.9
Right kidney weight	4.3	19.4	29.4	5.4	-3.1
Cocaine induced anxiety	0.2	0.3	0.4	0.5	-0.6
Post-drug Anxiety	0.2	0.2	0.3	0.4	-0.6
Baseline Anxiety	0.6	0.7	0.7	-0.8	0.8
Tail length	0.3	1.3	1.3	-1.1	1.1
Length with tail	0.0	0.1	0.2	0.2	-0.5
Length without tail	1.1	3.6	4.0	1.8	-2.0
Times rat made contact with spout	2.5	2.8	4.4	-1.1	2.1
Lifetime Intake	0.1	0.1	0.2	0.4	0.1
Liver weight, left	1.4	2.3	2.8	1.4	-1.7
Liver weight, right	0.1	0.1	0.2	0.2	-0.5
Locomotor activity	2.3	3.5	3.8	1.8	-1.9
Locomotor testing distance	0.1	0.2	0.3	-0.6	0.0
Locomotor testing rearing	1.4	2.9	3.6	1.5	-1.9
Locomotion in novel chamber	2.1	2.7	5.2	-0.5	2.3
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.4	-0.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.6	-0.8	0.3
Change in fecal boli incidents, locomotor task	0.3	0.3	0.3	0.5	-0.5
Time >=10cm from walls, locomotor time 1	1.3	1.4	1.6	1.1	-1.3
Bouts of movement, locomotor time 1	0.8	0.9	1.8	-0.2	1.3
Total resting periods, locomotor time 1	1.4	1.6	2.8	-0.6	1.7
Rest time, locomotor task time 1	3.1	3.9	5.6	-1.5	2.4
Distance moved, locomotor task time 1	2.0	2.9	3.9	1.4	-2.0
Vertical activity count, locomotor time 1	2.3	5.5	6.4	2.1	-2.5
Time >=10cm from walls, locomotor time 2	2.0	3.0	3.7	1.9	-1.5
Bouts of movement, locomotor time 2	0.4	0.6	0.7	-0.7	0.8
Total resting periods, locomotor time 2	0.3	0.5	0.6	-0.6	0.8
Rest time, locomotor task time 2	2.6	3.3	3.3	-1.8	1.8
Distance moved, locomotor task time 2	3.5	4.2	5.1	2.3	-1.8
Vertical activity count, locomotor time 2	3.2	4.3	5.3	2.3	-1.8
Light reinforcement 1	0.9	2.1	2.8	1.7	-1.2
Light reinforcement 2	4.6	7.1	8.4	2.9	-2.4
Bone: marrow area	0.7	1.5	1.8	1.4	-1.1
Bone: maximum diameter	4.1	7.7	9.1	2.5	-3.0
Bone: maximum force	0.4	0.8	1.3	0.5	-1.1
Bone: maximum moment	0.2	0.3	0.6	0.2	-0.8
Mean time between licks in bursts	1.6	3.8	5.2	-2.3	1.6
Mean num. licks in bursts	0.7	1.1	1.8	-0.6	1.4
Cd content in liver	0.2	0.3	0.4	-0.4	0.6
Co content in liver	1.5	1.7	1.8	1.3	-1.3
Cu content in liver	3.5	4.1	5.2	-2.3	1.8
Fe content in liver	0.3	0.4	0.7	0.3	-0.8
K content in liver	0.0	0.0	0.0	-0.1	0.2
Mg content in liver	0.1	0.1	0.2	0.1	-0.5
Mn content in liver	0.2	0.2	0.3	0.5	-0.4
Na content in liver	0.7	0.8	1.1	-1.1	0.6
Rb content in liver	0.6	0.7	0.8	0.7	-0.9
Se content in liver	0.3	0.4	0.8	0.1	0.9
Sr content in liver	2.2	1.9	2.6	-1.6	1.1
Zn content in liver	1.4	1.6	2.0	-1.4	1.1
Bone: minimum diameter	2.1	3.9	5.2	1.6	-2.3
Time in familiar zone, hab. session 1	0.6	0.6	0.9	-0.4	1.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.1	-0.5
Total zone transitions, hab. session 1	0.7	1.0	1.7	-1.3	0.5
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.4	-0.8
Locomotion velocity, hab. session 1	0.5	0.7	1.2	0.5	-1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	0.2
Time in novel zone, hab. session 2	0.4	0.4	0.5	-0.7	0.6
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.0	0.1
Total locomotion distance, hab. session 2	0.8	1.0	1.3	1.1	-0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.5	1.2	-1.0
Novel to familiar place preference ratio	1.0	1.1	1.1	-1.0	1.1
Novelty place preference	0.9	1.0	1.2	-0.9	1.1
Time in novel zone, NPP test	1.5	1.6	2.0	-1.1	1.4
Total zone transitions, NPP test	0.6	0.9	0.9	-1.0	0.9
Total locomotion distance, NPP test	0.3	0.4	0.4	0.6	-0.6
Locomotion velocity, NPP test	0.4	0.5	0.6	0.7	-0.8
Intraocular pressure	1.3	1.8	2.4	1.1	-1.6
Delta distance traveled before/after self-admin	0.5	0.6	0.8	0.6	0.9
Delta ambulatory time before/after self-admin	0.4	0.5	0.9	0.3	1.0
Parametrial fat weight	0.7	1.5	2.0	1.0	-1.4
Pavlov. Cond. lever latency	3.3	4.2	4.6	-2.0	2.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.0	-0.6
Pavlov. Cond. change in total contacts	2.4	2.6	4.1	1.0	-2.0
Pavlov. Cond. index score	0.8	1.0	1.6	0.6	-1.3
Pavlov. Cond. latency score	1.2	1.6	2.3	0.9	-1.5
Pavlov. Cond. lever contacts	3.2	3.9	4.3	1.9	-2.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	0.0	0.9
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.9	1.7	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.7	0.5	-1.3
Pavlov. Cond. response bias	1.1	1.3	1.8	0.9	-1.4
Pavlov. Cond. lever latency	0.7	1.0	1.4	-1.2	0.8
Pavlov. Cond. magazine entry latency	0.9	1.1	1.5	0.8	-1.2
Pavlov. Cond. change in total contacts	0.9	1.5	2.0	1.0	-1.4
Pavlov. Cond. index score	1.2	1.6	1.8	1.1	-1.3
Pavlov. Cond. latency score	1.3	1.7	1.7	1.3	-1.3
Pavlov. Cond. lever contacts	0.7	1.0	1.6	1.3	-0.6
Pavlov. Cond. magazine entry number	1.2	1.4	1.7	-1.1	1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.3	2.1	-0.6	1.5
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	1.7	1.2	-1.3
Pavlov. Cond. response bias	0.7	1.0	1.1	0.9	-1.1
Time in closed arm before self-admin	1.1	1.4	2.3	0.8	-1.5
Time in closed arm after self-admin	3.1	3.3	4.5	1.5	-2.1
Time in open arm before self-admin	1.4	1.5	1.9	-1.0	1.4
Time in open arm after self-admin	0.2	0.2	0.4	-0.3	0.6
Bone: periosteal estimation	2.5	5.3	6.4	2.1	-2.5
Bone: periosteal perimeter	5.8	10.0	11.9	2.8	-3.5
Bone: post-yield work	0.9	1.4	2.3	-1.5	0.6
Progressive ratio test 1 active lever presses	0.8	1.0	1.2	-0.8	1.1
Progressive ratio test 1 breakpoint	0.8	1.0	1.2	-0.9	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.2	0.5	-0.4
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	0.8	0.2
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	0.7	0.2
Progressive ratio test 2 inactive lever presses	0.5	0.8	1.4	1.2	-0.4
Incentive Sensitization - Responses	1.4	2.0	3.1	1.8	-1.0
Incentive Sensitization - Breakpoint	1.4	1.9	2.8	1.7	-1.0
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.4	0.5	-0.6
Progressive ratio	0.0	0.1	0.1	0.3	-0.2
Food seeking constrained by brief footshock	2.1	2.5	3.5	1.9	-1.2
Seeking ratio, punishment vs. effort	0.6	0.9	1.0	0.8	-1.0
Retroperitoneal fat weight	2.8	12.0	14.2	3.8	-3.1
Reaction time number correct	0.3	0.6	0.7	-0.8	0.8
Reaction time mean minus median	0.4	1.0	1.3	0.8	-1.1
Reaction time mean minus median AUC	0.1	0.2	0.3	0.6	-0.3
Reaction time num false alarms	0.0	0.0	0.1	-0.1	0.2
Reaction time num false alarms AUC	0.2	0.3	0.4	-0.4	0.7
Reaction time trials correct on left	0.3	0.6	0.7	-0.8	0.8
Reaction time trials on left	0.4	0.7	0.8	-0.9	0.8
Reaction time mean	0.9	1.4	1.5	-1.2	1.1
Reaction time mean AUC	0.9	1.4	1.5	-1.2	1.2
Median of all reaction times	2.4	3.5	3.8	-1.8	1.9
Reaction time omissions	1.0	1.4	1.7	-1.0	1.3
Reaction time false alarm rate	0.0	0.0	0.0	0.1	0.1
Reaction time premature initiation rate	6.2	8.5	10.4	3.2	-2.6
Reaction time premature initiations	2.0	3.6	4.7	2.2	-1.6
Std. dev. reaction times	0.0	0.0	0.1	0.1	-0.3
Reaction time trials completed	0.4	0.7	0.8	-0.9	0.8
Reaction time trials AUC	0.3	0.5	0.5	-0.7	0.7
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.4	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.0	-0.4
Latency to leave start box in cocaine runway	0.2	0.2	0.3	0.6	0.3
Latency to leave start box in cocaine runway, F	0.7	0.8	1.6	0.0	1.3
Latency to leave start box in cocaine runway, M	2.0	1.9	2.7	1.0	-1.6
Std. dev. time between licks in bursts	2.0	2.7	3.1	1.8	-1.5
Total sessions with >9 infusions	0.1	0.1	0.3	-0.1	0.5
Short access day 1 total inactive lever presses	0.8	1.1	2.0	1.4	-0.5
Short access day 10 total inactive lever presses	3.1	7.4	10.2	3.2	-2.2
Short access day 1 total infusions	0.2	0.3	0.5	0.2	0.7
Short access day 10 total infusions	0.2	0.2	0.4	0.6	0.2
Short access total infusions	0.1	0.1	0.2	0.5	0.2
Short access day 1 locomotion	0.3	0.4	0.7	0.2	0.8
Short access day 10 total locomotion	0.2	0.4	0.7	0.8	-0.3
Short access total locomotion	0.1	0.2	0.3	0.6	-0.1
One hour access (0.3 mA shock)	1.5	1.7	2.4	1.6	-1.0
Compulsive drug intake	0.0	0.0	0.0	0.1	-0.1
One hour access (shock baseline)	0.4	0.6	1.2	1.1	-0.3
Social response proportion	0.5	0.6	1.2	0.2	-1.1
Social responses	0.5	0.6	1.0	0.5	-1.0
Social time	0.2	0.2	0.3	-0.4	0.5
Soleus weight	0.2	0.7	1.4	1.2	-0.1
Bone: stiffness	0.2	0.2	0.4	-0.4	-0.6
Tibialis anterior weight	0.0	0.1	0.2	0.0	0.4
Time to tail flick, vehicle, before self-admin	2.2	2.3	3.1	1.8	-1.2
Time to tail flick, vehicle, after self-admin	0.4	0.6	1.0	1.0	-0.4
Time to tail flick, test, before self-admin	0.8	0.8	0.9	0.8	-1.0
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.9	0.3
Delta time to tail flick, vehicle, before/after SA	1.5	1.4	1.7	-1.1	1.3
Delta time to tail flick, test, before/after SA	0.4	0.4	0.8	-0.2	0.9
Tibia length	0.9	2.6	4.0	-2.0	1.1
Ambulatory time before self-admin	0.2	0.3	0.5	-0.7	-0.5
Ambulatory time after self-admin	0.1	0.1	0.1	-0.3	0.3
Bone: tissue strength	2.6	2.6	2.9	-1.5	1.7
Total heroin consumption	0.2	0.2	0.4	0.6	0.1
Bone: trabecular number	0.9	1.4	2.3	-0.7	1.5
Bone: trabecular spacing	1.8	2.3	2.9	1.3	-1.7
Bone: trabecular thickness	0.4	0.5	0.6	0.7	-0.7
Bone: trabecular tissue density	0.7	1.0	1.9	-1.4	-0.1
Water consumed over 24 hours	0.0	0.0	0.0	0.2	0.2
Number of responses in last shaping day	1.5	1.6	2.3	-1.0	1.5