Milr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	alternative polyA	XM_039086726.1	0.23	0.15	9.7e-03	0.04	0.03	0.02	0.03	4.4e-02	5.3e-02	9.0e-02	5.9e-02
2	Adipose	gene expression	Milr1	0.15	0.07	9.4e-07	0.07	0.07	0.06	0.08	2.4e-08	1.8e-08	2.0e-07	7.9e-09
3	IL	alternative polyA	XM_039086732.1	0.32	0.21	4.1e-03	0.07	0.04	0.08	0.08	9.7e-03	4.6e-02	4.9e-03	5.5e-03
4	LHb	alternative polyA	NM_001410245.1	0.26	0.16	7.7e-03	0.01	0.01	0	-0	1.7e-01	2.1e-01	3.0e-01	3.6e-01
5	LHb	alternative polyA	XM_039086732.1	0.21	0.13	8.9e-03	0.01	0	0	0	1.5e-01	2.5e-01	2.7e-01	3.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.2	2.0	5.6	2.4	0.4	1.6	-0.9	0.9
Area under the delay curve	0.2	0.2	0.4	0.6	-0.6	0.5	0.4	-0.4
BMI with tail	0.7	2.3	5.0	0.6	2.2	-1.1	1.5	-1.5
BMI without tail	1.2	2.4	7.5	2.0	2.7	0.2	0.5	-0.5
Body weight	1.3	5.5	13.3	3.7	3.0	1.9	-1.0	1.0
Weight adjusted by age	0.7	0.7	1.4	-1.2	-0.4	-0.7	0.9	-0.9
Bone surface	5.1	9.1	16.2	4.0	0.9	3.4	-2.9	2.9
Bone volume	3.9	6.6	13.5	3.7	0.8	2.9	-2.3	2.3
Breakpoint value in progressive ratio session	0.3	0.3	1.3	0.4	1.1	0.1	-0.3	0.3
Number of licking bursts	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1	0.1
Context. condit. distance diff. score	0.4	0.5	1.9	-0.6	1.4	-0.6	0.1	-0.1
Locomotion velocity, session 1	0.6	0.7	2.6	1.6	0.3	0.6	-0.4	0.4
Locomotion distance, session 1	0.2	0.3	0.6	0.8	0.8	0.0	0.3	-0.3
Locomotion velocity, session 2	0.3	0.4	1.2	0.4	1.1	-0.0	-0.5	0.5
Locomotion distance, session 2	0.5	0.7	2.5	0.3	1.6	-0.5	0.6	-0.6
Locomotion velocity, session 3	1.4	1.6	2.2	-0.5	1.3	-1.4	1.5	-1.5
Locomotion distance, session 3	0.0	0.1	0.1	-0.1	0.3	-0.3	0.1	-0.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	-0.1	-0.4	-0.4	1.0	-1.0
Stereotopy head waving duration, day 3	0.5	0.6	1.4	-0.3	-0.1	-0.5	1.2	-1.2
Locomotion velocity, session 7	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.1	-0.1
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.1	-0.5	0.0	-0.0
Stereotopy head waving bouts, day 7	1.1	1.3	1.7	-0.6	1.3	-1.1	1.3	-1.3
Stereotopy head waving duration, day 7	1.6	2.0	2.9	-1.4	0.5	-1.4	1.7	-1.7
Locomotion velocity, session 8	0.8	1.0	1.5	1.0	0.4	0.9	-1.2	1.2
Locomotion distance, session 8	0.4	0.6	2.8	-0.2	1.7	-0.3	0.0	-0.0
Degree of sensitization distance	0.3	0.3	0.4	0.4	-0.1	0.6	-0.6	0.6
Degree of sensitization stereotypy	2.3	2.5	3.8	-1.1	1.9	-1.7	1.5	-1.5
Conditioned locomotion	0.2	0.2	0.4	0.3	-0.3	0.5	-0.6	0.6
Cocaine response after cond. corrected	0.4	0.5	1.7	-0.4	-1.3	0.0	0.5	-0.5
Cocaine response after cond. not corrected	0.3	0.3	0.4	-0.6	-0.6	-0.2	0.6	-0.6
Cocaine response before conditioning	0.5	0.6	2.2	-0.3	1.5	-0.6	0.5	-0.5
Saline control response	0.7	1.0	4.3	0.6	2.1	0.0	-0.1	0.1
Bone: connectivity density	1.7	2.7	6.1	2.5	0.5	1.8	-1.4	1.4
Bone: cortical apparent density	3.5	4.6	6.6	-2.0	-0.2	-2.3	2.6	-2.6
Bone: cortical area	1.4	2.2	6.1	2.1	2.5	0.7	-0.2	0.2
Bone: cortical porosity	3.9	4.3	8.4	2.9	2.1	1.7	-1.7	1.7
Bone: cortical porosity	2.4	2.7	5.7	2.4	2.3	1.1	-0.7	0.7
Bone: cortical thickness	5.8	9.5	15.3	-1.5	1.8	-3.3	3.9	-3.9
Bone: cortical thickness	4.6	5.3	9.0	-1.8	1.7	-3.0	2.4	-2.4
Bone: cortical tissue density	3.3	4.3	6.2	-2.0	-0.4	-2.3	2.5	-2.5
Condit. Reinf. active minus inactive responses	1.3	1.4	4.2	1.4	2.1	0.7	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.8	0.9	3.1	0.9	1.8	0.4	-0.5	0.5
Condit. Reinf. active responses	1.4	1.7	3.1	1.7	1.8	1.2	-0.8	0.8
Condit. Reinf. inactive responses	0.5	0.6	1.4	1.2	0.0	1.0	-0.6	0.6
Incentive salience index mean	1.2	1.4	3.0	1.7	1.7	0.9	-0.6	0.6
Condit. Reinf. lever presses	0.2	0.2	0.7	0.8	0.7	0.0	0.2	-0.2
Condit. Reinf. active minus inactive responses	3.6	4.5	9.4	2.7	3.1	1.6	-1.2	1.2
Condit. Reinf. active-inactive response ratio	1.7	1.8	4.3	2.1	1.3	1.2	-0.9	0.9
Condit. Reinf. active responses	3.6	5.0	9.1	2.7	3.0	1.9	-1.6	1.6
Condit. Reinf. inactive responses	1.3	1.6	5.4	1.0	2.3	0.6	-0.8	0.8
Condit. Reinf. lever presses	1.4	1.9	7.2	1.3	2.7	0.3	-0.3	0.3
Condit. Reinf. lever reinforcers received	3.1	4.3	7.0	2.5	2.7	1.8	-1.6	1.6
Conditioned reinforcement - actives	0.3	0.3	1.3	1.2	0.5	0.2	-0.0	0.0
Conditioned reinforcement - inactives	1.2	1.3	2.2	1.5	1.1	1.0	-1.1	1.1
Conditioned locomotion	1.4	1.7	5.0	2.2	0.8	1.2	-0.8	0.8
Patch foraging indifference point 0 sec	2.2	3.5	7.4	2.7	2.2	1.5	-1.2	1.2
Patch foraging indifference point AUC	1.2	1.3	2.5	1.3	0.6	1.6	-1.0	1.0
Delay disc. indifference point, 0s delay	0.8	0.8	2.5	-1.0	-1.6	-0.1	0.5	-0.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	0.8	-0.1	0.2	0.6	-0.6
Delay disc. indifference point, 2s delay	0.9	1.0	2.6	1.1	-0.8	1.6	-0.6	0.6
Delay disc. indifference point, 24s delay	1.0	1.0	3.6	1.9	0.5	1.0	-0.1	0.1
Delay disc. indifference point, 4s delay	0.4	0.5	0.6	-0.7	-0.6	-0.5	0.8	-0.8
Delay disc. indifference point, 8s delay	0.4	0.4	0.7	0.1	-0.8	-0.1	0.9	-0.9
Indifference point function ln k	1.1	1.6	2.3	-0.5	0.8	-1.5	1.5	-1.5
Indifference point function log k	1.1	1.6	2.3	-0.5	0.8	-1.5	1.5	-1.5
Patch foraging total patch changes 0 sec	2.3	3.8	8.0	2.8	2.1	1.7	-1.3	1.3
Patch foraging total patch changes 12 sec	3.7	4.8	7.2	2.5	0.9	2.7	-2.2	2.2
Patch foraging total patch changes 18 sec	1.6	2.1	3.0	1.7	1.7	1.2	-1.2	1.2
Patch foraging total patch changes 24 sec	2.3	2.8	5.8	2.4	1.8	1.7	-1.1	1.1
Patch foraging total patch changes 6 sec	1.7	2.5	3.9	2.0	1.6	1.6	-1.3	1.3
Patch foraging time to switch 0 sec	0.2	0.3	0.6	-0.8	-0.8	-0.5	-0.1	0.1
Patch foraging water rate 0 sec	1.1	1.8	4.2	2.1	1.4	1.1	-0.8	0.8
Patch foraging water rate 12 sec	0.9	1.4	2.4	-0.7	0.8	-1.5	1.4	-1.4
Patch foraging water rate 18 sec	0.6	0.8	1.4	0.3	1.2	-0.8	1.0	-1.0
Patch foraging water rate 24 sec	0.2	0.3	0.4	0.1	0.6	-0.5	0.6	-0.6
Patch foraging water rate 6 sec	0.4	0.6	1.1	0.3	0.5	-0.7	1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	0.3	-0.2	0.1	-0.1
Distance traveled before self-admin	0.4	0.4	1.3	-1.1	-0.1	-0.5	0.6	-0.6
Distance traveled after self-admin	0.4	0.5	1.0	-0.9	1.0	-0.6	0.4	-0.4
Extensor digitorum longus weight	1.2	4.7	15.0	-2.4	-3.9	-0.9	0.9	-0.9
Bone: elastic displacement	1.6	1.8	3.0	-0.7	0.5	-1.5	1.7	-1.7
Bone: elastic work	0.2	0.2	0.8	0.9	0.4	-0.2	0.3	-0.3
Bone: endosteal estimation	12.3	26.7	34.5	5.5	1.9	5.5	-5.9	5.9
Bone: endosteal perimeter	13.5	28.1	36.2	6.0	2.1	5.8	-5.7	5.7
Epididymis fat weight	0.8	1.8	3.7	1.9	-0.7	1.7	-1.1	1.1
Delta time in closed arm before/after self-admin	0.3	0.2	0.4	0.3	-0.5	0.6	-0.5	0.5
Delta time in open arm before/after self-admin	0.6	0.5	0.8	-0.9	-0.5	-0.7	0.8	-0.8
Diff in mean of infusions in LGA sessions	1.3	1.5	2.4	-1.1	0.3	-1.5	1.3	-1.3
Delay discount exponential model param	0.3	0.4	0.9	-0.9	0.6	-0.8	-0.0	0.0
Extinction: sum of active levers before priming	0.1	0.1	0.5	0.2	0.7	0.1	-0.1	0.1
Active lever presses in extinction session 6	0.9	0.9	1.5	1.2	0.7	0.8	-0.9	0.9
Bone: final force	0.7	1.1	2.3	1.5	1.4	0.8	-0.6	0.6
Bone: final moment	0.8	1.2	2.6	1.6	1.4	0.9	-0.7	0.7
Food consumed during 24 hour testing period	1.6	1.9	5.3	2.3	0.6	1.5	-0.9	0.9
Glucose	0.7	1.1	2.0	-1.4	-0.3	-0.9	1.1	-1.1
Heart weight	0.4	0.6	1.1	-0.1	0.6	-0.6	1.1	-1.1
Delay discount hyperbolic model param	0.3	0.3	0.6	-0.8	0.6	-0.7	-0.1	0.1
Intermittent access intake day 1-15 change	1.3	1.3	2.2	0.2	-1.1	0.9	-1.5	1.5
Intermittent access intake escalation	0.8	0.8	1.3	0.0	-1.1	0.6	-1.1	1.1
Intermittent access intake escalation 2	2.5	2.4	4.0	0.8	-1.3	1.4	-2.0	2.0
Intermitt. access day 1 inactive lever presses	2.8	3.0	7.2	2.2	2.7	1.1	-0.9	0.9
Intermitt. access day 15 inactive lever presses	0.9	1.0	2.6	1.6	0.5	0.6	-0.9	0.9
Intermitt. access escalation Index	2.3	2.0	4.1	-2.0	-0.6	-1.3	1.4	-1.4
Intermittent access day 1 total infusions	0.7	0.8	2.0	1.2	1.4	0.1	0.4	-0.4
Intermittent access day 15 total infusions	0.3	0.3	1.0	1.0	0.0	0.5	-0.4	0.4
Intermittent access terminal intake (last 3 days)	1.8	1.9	3.6	1.9	0.1	1.5	-1.4	1.4
Intermittent access total infusions	1.6	1.8	4.8	2.2	1.3	1.1	-0.8	0.8
Intermittent access day 1 locomotion	2.0	2.1	6.7	2.6	1.7	0.9	-0.4	0.4
Intermittent access day 15 total locomotion	4.0	4.3	9.6	3.1	1.3	1.9	-1.8	1.8
Intermittent access total locomotion	4.9	5.6	14.7	3.8	2.3	1.9	-1.5	1.5
Intermittent access standard deviation	1.0	1.1	2.9	1.7	0.6	0.6	-1.0	1.0
Left kidney weight	1.9	5.4	7.3	-0.5	2.6	-2.3	2.7	-2.7
Right kidney weight	0.9	2.6	4.0	0.3	2.0	-1.4	1.9	-1.9
Cocaine induced anxiety	0.2	0.2	0.3	-0.2	0.1	-0.6	0.6	-0.6
Post-drug Anxiety	0.3	0.3	0.9	-0.4	-0.9	-0.3	0.4	-0.4
Baseline Anxiety	0.6	0.6	0.8	-0.8	-0.9	-0.6	0.8	-0.8
Tail length	1.6	4.8	9.4	3.1	0.8	2.6	-1.9	1.9
Length with tail	1.9	7.0	11.5	3.4	0.6	3.3	-2.5	2.5
Length without tail	0.8	1.7	2.9	1.2	-0.6	1.7	-1.3	1.3
Times rat made contact with spout	0.6	0.7	1.8	1.3	0.0	1.1	-0.6	0.6
Lifetime Intake	1.9	2.1	5.2	2.3	2.0	0.8	-0.5	0.5
Liver weight, left	1.0	1.6	2.9	1.4	0.5	1.7	-1.2	1.2
Liver weight, right	0.1	0.1	0.3	0.2	0.5	0.1	0.5	-0.5
Locomotor activity	2.4	3.8	15.5	1.0	3.9	-1.0	0.9	-0.9
Locomotor testing distance	2.7	4.5	18.4	1.3	4.3	-1.0	0.7	-0.7
Locomotor testing rearing	1.5	2.3	9.8	0.8	3.1	-0.8	-0.4	0.4
Locomotion in novel chamber	0.0	0.0	0.1	0.2	0.1	0.2	0.1	-0.1
Locomotion in novel chamber post-restriction	2.6	3.1	5.6	1.5	-0.5	2.4	-1.9	1.9
Fecal boli incidents, locomotor time 1	0.2	0.3	1.2	-0.3	-1.1	0.1	0.2	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	0.1	-0.9	-0.0	0.2	-0.2
Time >=10cm from walls, locomotor time 1	1.4	1.4	4.3	-2.1	0.2	-1.2	0.8	-0.8
Bouts of movement, locomotor time 1	0.3	0.3	0.8	-0.5	-0.9	-0.5	0.4	-0.4
Total resting periods, locomotor time 1	0.4	0.5	1.9	-0.5	-1.4	-0.3	0.2	-0.2
Rest time, locomotor task time 1	0.8	0.9	4.2	-0.5	-2.1	0.2	-0.1	0.1
Distance moved, locomotor task time 1	0.9	0.9	1.8	1.3	1.3	0.6	-0.7	0.7
Vertical activity count, locomotor time 1	0.5	0.6	1.5	1.0	1.2	0.4	-0.3	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.6	-0.4	-0.2	-0.3	0.3
Bouts of movement, locomotor time 2	0.4	0.4	1.1	-1.1	-0.4	-0.6	0.5	-0.5
Total resting periods, locomotor time 2	0.7	0.8	1.9	-1.4	-0.5	-0.9	0.7	-0.7
Rest time, locomotor task time 2	3.6	4.1	7.4	-2.5	-2.7	-1.3	1.6	-1.6
Distance moved, locomotor task time 2	0.8	0.9	1.4	1.2	1.2	0.4	-0.9	0.9
Vertical activity count, locomotor time 2	2.3	2.5	4.1	2.0	1.9	0.9	-1.4	1.4
Light reinforcement 1	0.6	1.1	2.0	0.4	1.0	-0.5	1.4	-1.4
Light reinforcement 2	0.2	0.3	0.9	1.0	-0.2	0.6	0.3	-0.3
Bone: marrow area	12.1	26.2	34.0	5.5	1.9	5.4	-5.8	5.8
Bone: maximum diameter	3.6	6.7	10.1	3.2	1.7	3.0	-2.4	2.4
Bone: maximum force	1.2	2.0	4.9	2.2	1.6	1.2	-0.7	0.7
Bone: maximum moment	1.3	2.2	5.3	2.3	1.5	1.4	-0.9	0.9
Mean time between licks in bursts	0.1	0.1	0.3	0.2	-0.1	0.6	-0.3	0.3
Mean num. licks in bursts	0.2	0.2	0.8	0.9	-0.1	0.5	-0.1	0.1
Cd content in liver	1.7	1.9	4.3	-2.1	-1.6	-1.2	0.7	-0.7
Co content in liver	0.2	0.2	0.9	-0.9	-0.3	-0.3	-0.2	0.2
Cu content in liver	0.3	0.4	1.5	0.3	-1.2	0.4	-0.3	0.3
Fe content in liver	0.5	0.6	1.2	-1.0	0.5	-1.1	0.5	-0.5
K content in liver	1.0	1.0	2.1	0.9	-0.6	1.4	-0.9	0.9
Mg content in liver	1.2	1.2	2.9	0.0	-1.7	1.2	-1.0	1.0
Mn content in liver	0.1	0.1	0.2	0.3	-0.0	0.5	0.1	-0.1
Na content in liver	0.4	0.4	1.9	0.1	1.4	0.2	0.2	-0.2
Rb content in liver	1.4	1.8	5.1	-2.3	-1.0	-1.2	0.9	-0.9
Se content in liver	1.1	1.3	2.0	-1.4	-0.3	-0.9	1.3	-1.3
Sr content in liver	0.5	0.4	1.0	1.0	1.0	0.3	-0.3	0.3
Zn content in liver	0.1	0.1	0.3	0.5	0.1	0.4	0.3	-0.3
Bone: minimum diameter	9.7	18.1	29.8	5.5	2.3	4.7	-4.1	4.1
Time in familiar zone, hab. session 1	1.5	1.4	2.0	0.6	-1.1	1.4	-1.3	1.3
Time in novel zone, hab. session 1	1.8	1.8	2.8	-1.1	1.0	-1.7	1.4	-1.4
Total zone transitions, hab. session 1	0.5	0.7	2.3	1.0	1.5	-0.4	0.3	-0.3
Total locomotion distance, hab. session 1	1.2	1.7	4.8	1.9	2.2	0.0	0.1	-0.1
Locomotion velocity, hab. session 1	1.2	1.7	4.7	2.2	1.8	0.5	-0.3	0.3
Time in familiar zone, hab. session 2	1.3	1.4	2.1	0.8	1.0	1.0	-1.5	1.5
Time in novel zone, hab. session 2	0.8	0.8	1.3	-0.7	-1.1	-0.7	1.0	-1.0
Total zone transitions, hab. session 2	0.5	0.6	2.8	0.4	1.7	-0.2	0.3	-0.3
Total locomotion distance, hab. session 2	0.5	0.7	1.8	1.2	1.3	0.4	-0.1	0.1
Locomotion velocity, hab. session 2	0.5	0.6	1.6	1.3	1.1	0.5	-0.1	0.1
Novel to familiar place preference ratio	0.3	0.3	0.5	0.7	0.4	0.6	-0.6	0.6
Novelty place preference	0.2	0.2	0.3	0.5	0.5	0.3	-0.4	0.4
Time in novel zone, NPP test	0.2	0.2	0.7	0.3	0.8	0.1	-0.3	0.3
Total zone transitions, NPP test	1.1	1.6	4.2	0.7	2.1	-0.6	1.2	-1.2
Total locomotion distance, NPP test	0.7	1.0	2.5	1.6	1.5	0.2	-0.2	0.2
Locomotion velocity, NPP test	0.5	0.8	2.0	1.4	1.3	0.0	0.3	-0.3
Intraocular pressure	0.2	0.3	0.6	0.8	0.5	-0.1	0.6	-0.6
Delta distance traveled before/after self-admin	1.2	1.3	2.7	-0.5	1.7	-1.3	0.9	-0.9
Delta ambulatory time before/after self-admin	0.2	0.2	1.0	0.2	1.0	-0.3	0.2	-0.2
Parametrial fat weight	2.2	4.2	5.5	2.3	-1.6	2.3	-2.0	2.0
Pavlov. Cond. lever latency	1.8	2.3	6.9	-2.1	-2.6	-0.2	-0.1	0.1
Pavlov. Cond. magazine entry latency	2.1	2.8	5.7	2.4	2.2	1.2	-0.9	0.9
Pavlov. Cond. change in total contacts	1.9	2.0	6.1	1.9	2.5	0.4	-0.3	0.3
Pavlov. Cond. index score	2.2	2.8	7.8	2.3	2.8	0.7	-0.5	0.5
Pavlov. Cond. latency score	2.1	2.6	8.4	2.1	2.9	0.5	-0.3	0.3
Pavlov. Cond. lever contacts	1.2	1.4	4.2	1.7	2.0	0.2	-0.0	0.0
Pavlov. Cond. magazine entry number	1.6	2.0	4.4	-2.0	-2.1	-0.8	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.6	0.8	0.6	0.0	-0.0
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	7.1	2.2	2.7	0.6	-0.4	0.4
Pavlov. Cond. response bias	2.0	2.4	6.0	2.4	2.3	0.8	-0.4	0.4
Pavlov. Cond. lever latency	0.2	0.3	1.1	-0.4	-1.1	-0.2	-0.2	0.2
Pavlov. Cond. magazine entry latency	1.5	1.8	4.1	-2.0	-0.6	-1.2	1.2	-1.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	0.4	1.0	0.4	-0.3	0.3
Pavlov. Cond. index score	0.2	0.2	0.6	-0.4	0.7	-0.3	0.4	-0.4
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.6	0.8	-0.5	0.6	-0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.9	0.5	0.9	0.1	0.2	-0.2
Pavlov. Cond. magazine entry number	2.1	2.6	4.8	2.2	0.3	1.7	-1.6	1.6
Pavlov. Cond. intertrial magazine entries	10.3	13.5	19.1	4.4	-0.3	4.2	-3.9	3.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.6	0.6	-0.3	0.5	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.1	0.6	-0.1	0.3	-0.3
Time in closed arm before self-admin	2.0	2.3	3.7	-1.0	1.8	-1.9	1.3	-1.3
Time in closed arm after self-admin	0.1	0.1	0.4	-0.6	0.1	-0.5	0.0	-0.0
Time in open arm before self-admin	0.3	0.3	1.0	-0.5	-1.0	-0.1	0.3	-0.3
Time in open arm after self-admin	0.3	0.3	1.3	0.0	-1.1	0.3	0.0	-0.0
Bone: periosteal estimation	7.2	14.9	23.0	4.8	2.6	4.0	-3.8	3.8
Bone: periosteal perimeter	4.0	6.6	11.6	3.4	2.3	2.6	-2.2	2.2
Bone: post-yield work	2.2	3.0	4.2	2.0	0.7	1.9	-1.9	1.9
Progressive ratio test 1 active lever presses	2.7	2.8	6.3	2.5	2.4	1.1	-0.6	0.6
Progressive ratio test 1 breakpoint	3.1	3.3	7.3	2.7	2.6	1.1	-0.7	0.7
Progressive ratio test 1 inactive lever presses	2.9	3.2	9.7	2.3	3.1	0.8	-0.3	0.3
Progressive ratio test 2 active lever presses	3.0	3.2	8.3	2.9	1.0	1.8	-1.3	1.3
Progressive ratio test 2 breakpoint	3.4	3.8	9.0	3.0	0.9	2.0	-1.6	1.6
Progressive ratio test 2 inactive lever presses	2.6	3.0	8.3	2.9	1.2	1.7	-1.1	1.1
Incentive Sensitization - Responses	2.7	2.8	4.4	2.1	-0.2	2.0	-1.6	1.6
Incentive Sensitization - Breakpoint	2.7	2.7	4.2	2.0	-0.2	2.0	-1.6	1.6
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.7	-1.1	0.4	-1.3	1.2	-1.2
Progressive ratio	0.7	0.8	2.7	-0.1	-1.6	0.9	-0.5	0.5
Food seeking constrained by brief footshock	3.8	4.7	6.9	2.0	0.1	2.3	-2.6	2.6
Seeking ratio, punishment vs. effort	1.0	1.2	2.6	1.2	1.6	0.6	-1.0	1.0
Retroperitoneal fat weight	1.6	5.2	10.1	3.2	0.4	2.3	-2.3	2.3
Reaction time number correct	0.8	1.1	2.2	-0.6	-0.1	-0.8	1.5	-1.5
Reaction time mean minus median	0.5	0.7	2.8	-0.7	-1.7	-0.2	0.1	-0.1
Reaction time mean minus median AUC	1.0	1.3	1.8	-1.3	-1.0	-1.0	1.1	-1.1
Reaction time num false alarms	2.2	3.0	7.0	2.1	2.7	1.2	-1.1	1.1
Reaction time num false alarms AUC	2.5	3.4	5.6	2.4	2.3	1.6	-1.4	1.4
Reaction time trials correct on left	0.8	1.1	2.2	-0.6	-0.1	-0.8	1.5	-1.5
Reaction time trials on left	0.7	1.0	2.0	-0.6	-0.2	-0.8	1.4	-1.4
Reaction time mean	0.6	0.8	1.8	-1.4	-1.1	-0.8	0.3	-0.3
Reaction time mean AUC	0.9	1.2	2.9	-1.7	-1.1	-1.1	0.5	-0.5
Median of all reaction times	0.5	0.7	1.9	-1.4	-0.8	-0.9	0.3	-0.3
Reaction time omissions	0.7	0.9	3.2	-0.1	-1.8	0.6	-0.8	0.8
Reaction time false alarm rate	2.6	3.7	4.8	2.2	2.1	1.6	-1.8	1.8
Reaction time premature initiation rate	0.4	0.5	1.3	1.0	1.1	0.1	0.3	-0.3
Reaction time premature initiations	0.4	0.6	0.9	0.7	0.8	-0.1	0.9	-0.9
Std. dev. reaction times	0.7	1.0	4.1	-0.9	-2.0	-0.0	-0.4	0.4
Reaction time trials completed	0.7	1.0	2.0	-0.6	-0.2	-0.8	1.4	-1.4
Reaction time trials AUC	0.6	0.9	1.7	-0.6	-0.2	-0.7	1.3	-1.3
Run reversals in cocaine runway, females	0.7	0.7	2.8	-0.1	-1.7	-0.5	0.4	-0.4
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.3	-0.3
Latency to leave start box in cocaine runway	0.4	0.4	0.8	-0.9	0.2	-0.7	0.6	-0.6
Latency to leave start box in cocaine runway, F	1.4	1.5	1.9	-1.2	1.2	-1.4	1.2	-1.2
Latency to leave start box in cocaine runway, M	0.6	0.6	2.0	-0.1	-1.4	0.4	-0.6	0.6
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.1	0.1
Total sessions with >9 infusions	2.1	2.3	5.0	0.8	2.2	-1.0	1.6	-1.6
Short access day 1 total inactive lever presses	0.9	1.0	3.2	1.3	1.8	0.3	-0.1	0.1
Short access day 10 total inactive lever presses	0.3	0.3	0.6	0.8	0.1	0.5	-0.6	0.6
Short access day 1 total infusions	2.8	3.0	9.3	1.2	3.0	-0.8	1.4	-1.4
Short access day 10 total infusions	3.1	3.5	8.0	2.8	2.3	1.4	-1.1	1.1
Short access total infusions	2.6	2.9	10.6	2.0	3.3	-0.0	0.1	-0.1
Short access day 1 locomotion	2.3	2.4	6.1	2.3	2.5	0.3	0.5	-0.5
Short access day 10 total locomotion	6.3	7.0	17.0	4.1	2.1	2.3	-2.0	2.0
Short access total locomotion	3.4	3.5	9.2	2.8	3.0	0.5	-0.2	0.2
One hour access (0.3 mA shock)	0.6	0.7	0.9	1.0	1.0	0.6	-0.8	0.8
Compulsive drug intake	0.7	0.7	0.9	-0.9	-0.1	-0.9	0.9	-0.9
One hour access (shock baseline)	1.0	1.1	1.7	1.3	0.7	1.0	-1.1	1.1
Social response proportion	0.2	0.3	0.4	-0.5	-0.3	-0.4	0.6	-0.6
Social responses	0.6	0.7	2.6	0.2	1.6	-0.6	0.5	-0.5
Social time	0.2	0.2	1.1	-0.0	-1.1	0.1	0.1	-0.1
Soleus weight	0.4	1.2	4.1	0.6	2.0	-0.2	0.8	-0.8
Bone: stiffness	0.6	0.9	1.5	1.2	1.1	1.0	-0.7	0.7
Tibialis anterior weight	0.1	0.3	0.7	0.6	-0.8	0.7	-0.2	0.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.9	-0.3	-1.7	0.7	-0.5	0.5
Time to tail flick, vehicle, after self-admin	1.0	1.0	2.1	0.6	-1.3	1.4	-0.7	0.7
Time to tail flick, test, before self-admin	1.1	1.1	4.4	-0.9	-2.1	0.0	-0.3	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.4	-0.2	-0.3	0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.2	1.4	-0.3	1.5	-1.3	1.3
Delta time to tail flick, test, before/after SA	0.2	0.1	0.4	0.0	0.6	-0.0	0.4	-0.4
Tibia length	0.5	1.3	2.7	1.0	1.7	-0.3	1.2	-1.2
Ambulatory time before self-admin	0.1	0.1	0.4	-0.7	0.1	-0.2	0.3	-0.3
Ambulatory time after self-admin	0.4	0.4	1.7	-0.3	1.3	-0.4	0.3	-0.3
Bone: tissue strength	1.0	1.0	1.8	-0.8	-0.1	-0.8	1.3	-1.3
Total heroin consumption	0.3	0.4	1.9	0.3	1.4	-0.0	0.0	-0.0
Bone: trabecular number	1.6	2.6	6.4	2.5	1.0	1.8	-1.0	1.0
Bone: trabecular spacing	0.4	0.6	2.0	-1.4	-0.5	-0.7	0.2	-0.2
Bone: trabecular thickness	2.0	2.4	6.6	2.6	-0.2	1.8	-1.0	1.0
Bone: trabecular tissue density	0.7	1.0	2.0	-0.6	-0.1	-0.9	1.4	-1.4
Water consumed over 24 hours	0.2	0.2	0.7	0.8	0.3	0.0	0.3	-0.3
Number of responses in last shaping day	0.7	0.7	2.2	1.0	1.5	-0.3	0.5	-0.5