Hub : Genes

Micb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Micb 0.37 0.24 1.2e-06 0.15 0.22 0.18 0.24 2.0e-04 4.7e-06 4.1e-05 2.3e-06
2 BLA mRNA stability Micb 0.07 0.07 7.1e-03 0.02 0.01 0 0.01 1.8e-02 9.5e-02 2.4e-01 9.6e-02
3 Brain gene expression Micb 0.22 0.11 0.0e+00 0.25 0.28 0.27 0.27 1.5e-23 3.0e-26 2.4e-25 2.5e-25
4 Eye gene expression Micb 0.51 0.26 3.3e-04 0.06 0.07 0.1 0.08 3.8e-02 3.7e-02 1.5e-02 2.6e-02
5 NAcc intron excision ratio chr1_87624700_87638482 0.2 0.13 0.0e+00 0.13 0.13 0.13 0.13 6.3e-19 1.0e-18 5.0e-19 4.9e-19
6 LHb mRNA stability Micb 0.54 0.26 2.4e-10 0.31 0.43 0.34 0.4 3.2e-08 1.6e-11 6.1e-09 1.1e-10
7 Brain mRNA stability Micb 0.15 0.09 0.0e+00 0.17 0.18 0.17 0.17 1.0e-15 1.1e-16 2.0e-15 2.8e-15
8 PL intron excision ratio chr1_87624700_87638482 0.07 0.05 5.3e-09 0.08 0.08 0.08 0.08 9.5e-09 1.8e-09 2.4e-09 5.3e-09
9 Adipose intron excision ratio chr1_87640903_87642210 0.04 0.04 7.6e-05 0.03 0.03 0.03 0.03 2.4e-04 1.2e-04 3.8e-04 3.7e-04
10 NAcc intron excision ratio chr1_87640903_87642210 0.03 0.02 2.2e-04 0.02 0.02 0.02 0.02 2.1e-04 1.5e-04 1.8e-04 2.0e-04
11 PL intron excision ratio chr1_87623943_87638482 0.07 0.05 2.3e-09 0.09 0.09 0.08 0.08 9.8e-10 8.2e-10 1.7e-09 2.6e-09
12 NAcc intron excision ratio chr1_87623943_87638482 0.19 0.13 0.0e+00 0.12 0.12 0.13 0.12 2.4e-18 3.7e-18 1.6e-18 2.1e-18
13 IC intron excision ratio chr1_87623943_87638482 0.15 0.11 4.0e-04 0.07 0.06 0.06 0.06 4.5e-04 1.9e-03 1.3e-03 1.2e-03
14 IC intron excision ratio chr1_87624700_87638482 0.15 0.11 3.9e-04 0.08 0.06 0.06 0.06 4.3e-04 1.8e-03 1.2e-03 1.3e-03
15 Liver gene expression Micb 0.12 0.09 5.3e-14 0.11 0.12 0.11 0.11 2.5e-12 4.6e-13 1.6e-12 2.0e-12
16 pVTA gene expression Micb 0.08 0.06 4.0e-05 0.04 0.04 0.03 0.04 3.1e-04 4.6e-04 2.2e-03 4.5e-04
17 IL gene expression Micb 0.16 0.17 8.8e-03 0.05 0.05 0.01 0.04 2.9e-02 2.3e-02 1.4e-01 3.6e-02
18 NAcc mRNA stability Micb 0.12 0.07 0.0e+00 0.12 0.12 0.12 0.12 2.2e-18 7.7e-18 2.3e-17 4.9e-18
19 Adipose mRNA stability Micb 0.77 0.06 0.0e+00 0.65 0.65 0.65 0.65 1.2e-94 3.4e-95 6.8e-96 9.4e-96
20 NAcc gene expression Micb 0.3 0.12 0.0e+00 0.33 0.32 0.32 0.32 6.1e-51 2.5e-50 1.3e-50 1.5e-50
21 PL gene expression Micb 0.13 0.09 2.8e-16 0.15 0.15 0.15 0.15 2.0e-16 5.0e-16 5.0e-16 7.4e-16
22 Adipose gene expression Micb 0.79 0.04 0.0e+00 0.7 0.7 0.7 0.7 2.3e-107 3.9e-110 3.6e-109 2.9e-108
23 PL mRNA stability Micb 0.02 0.02 6.2e-03 0.01 0.01 0.02 0.01 4.6e-02 1.5e-02 2.9e-03 6.8e-02
24 Brain intron excision ratio chr1_87624700_87638482 0.09 0.07 2.9e-10 0.1 0.1 0.1 0.1 2.6e-09 6.9e-10 5.5e-10 1.9e-09
25 Brain intron excision ratio chr1_87623943_87638482 0.1 0.07 4.3e-11 0.11 0.11 0.12 0.11 2.0e-10 1.2e-10 6.3e-11 3.0e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bone: apparent density0.00.00.20.30.10.1-0.00.10.10.1-0.10.00.00.1-0.10.0-0.0-0.00.1-0.00.1-0.0-0.2-0.1-0.20.40.5-0.5
Area under the delay curve1.31.52.3-0.9-0.8-1.2-1.31.3-1.2-1.21.2-1.2-1.2-1.2-1.3-1.31.3-1.3-1.4-1.3-1.1-1.4-1.5-1.3-1.5-0.90.7-0.8
BMI with tail0.72.24.22.02.01.71.5-1.41.71.7-1.61.61.61.61.51.5-1.51.51.61.51.61.31.21.40.80.8-1.00.8
BMI without tail0.92.85.92.42.41.91.6-1.51.91.9-1.81.81.81.81.51.7-1.71.61.61.71.91.51.31.50.91.4-1.31.0
Body weight1.46.09.63.13.12.72.4-2.32.72.6-2.62.62.62.62.32.6-2.62.42.42.42.72.22.12.21.61.7-2.21.9
Weight adjusted by age0.00.10.80.30.30.2-0.00.00.10.1-0.10.10.10.10.0-0.10.10.1-0.00.10.10.0-0.00.0-0.20.30.7-0.9
Bone surface0.30.51.31.20.90.80.6-0.60.80.8-0.80.70.70.80.60.6-0.60.70.60.70.70.60.60.50.31.1-0.20.0
Bone volume0.20.30.90.80.70.60.6-0.50.60.6-0.60.60.60.60.50.5-0.50.60.60.50.60.50.40.40.31.00.1-0.3
Breakpoint value in progressive ratio session2.02.53.7-1.9-1.9-1.8-1.51.6-1.7-1.81.7-1.7-1.7-1.7-1.6-1.31.3-1.7-1.5-1.7-1.3-1.6-1.5-1.6-1.3-1.50.8-0.6
Number of licking bursts2.64.24.62.01.92.12.1-2.12.12.1-2.12.12.12.12.12.0-2.02.12.12.12.02.12.12.12.11.7-1.91.8
Context. condit. distance diff. score0.10.10.30.20.10.30.3-0.30.30.3-0.30.30.30.30.30.3-0.30.30.30.30.30.40.30.40.60.3-0.40.4
Locomotion velocity, session 10.10.10.5-0.7-0.4-0.4-0.10.2-0.4-0.30.3-0.3-0.3-0.3-0.2-0.20.2-0.3-0.1-0.3-0.2-0.1-0.3-0.10.20.00.6-0.6
Locomotion distance, session 10.00.00.2-0.2-0.0-0.10.0-0.0-0.1-0.10.0-0.0-0.0-0.00.1-0.10.1-0.00.0-0.0-0.10.00.1-0.00.10.20.4-0.4
Locomotion velocity, session 21.41.62.01.41.41.41.3-1.31.41.4-1.41.41.41.41.31.3-1.31.31.21.31.31.31.21.41.21.3-0.40.3
Locomotion distance, session 20.20.30.80.80.80.60.5-0.50.60.6-0.60.60.60.60.50.4-0.40.50.50.50.40.50.50.40.40.90.1-0.3
Locomotion velocity, session 30.20.20.50.60.70.60.5-0.50.60.6-0.50.50.60.50.50.5-0.50.50.30.50.50.50.40.50.30.70.0-0.1
Locomotion distance, session 30.91.02.4-0.8-0.7-0.9-1.01.0-0.9-0.90.9-0.9-0.9-0.9-1.0-1.01.0-0.9-1.1-0.9-1.0-1.0-0.9-1.0-1.2-0.51.5-1.6
Stereotopy head waving bouts, day 31.21.42.40.91.01.11.3-1.21.11.1-1.11.11.11.11.21.1-1.11.21.21.11.11.21.11.21.31.0-1.61.5
Stereotopy head waving duration, day 31.11.32.00.80.81.11.3-1.21.01.1-1.11.11.11.11.21.0-1.01.11.21.11.01.21.21.21.40.8-1.41.3
Locomotion velocity, session 70.20.30.5-0.7-0.6-0.6-0.50.4-0.6-0.60.6-0.5-0.5-0.6-0.4-0.40.4-0.5-0.6-0.5-0.4-0.5-0.4-0.5-0.5-0.30.4-0.4
Locomotion distance, session 70.10.10.60.30.30.2-0.0-0.10.20.1-0.10.10.10.10.10.1-0.10.10.00.10.1-0.00.2-0.1-0.20.2-0.80.7
Stereotopy head waving bouts, day 71.01.12.20.60.61.01.3-1.21.01.0-1.01.01.01.01.11.1-1.11.11.21.11.11.31.11.31.51.3-0.70.6
Stereotopy head waving duration, day 70.81.02.00.70.70.91.2-1.10.91.0-1.01.01.01.01.01.0-1.01.01.01.01.01.11.01.21.31.4-0.30.2
Locomotion velocity, session 80.00.00.1-0.10.0-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.1-0.20.2-0.1-0.1-0.0-0.2-0.0-0.1-0.00.00.40.3-0.3
Locomotion distance, session 80.00.00.10.20.20.0-0.00.00.00.0-0.00.00.00.0-0.0-0.00.00.0-0.00.0-0.00.0-0.00.00.00.40.1-0.2
Degree of sensitization distance0.90.94.20.90.80.80.7-0.80.80.8-0.80.80.80.80.80.8-0.80.80.90.80.80.70.80.60.80.5-2.02.0
Degree of sensitization stereotypy1.11.12.00.70.71.01.3-1.11.01.0-1.01.11.01.01.11.2-1.21.11.21.11.21.21.11.31.41.4-0.1-0.0
Conditioned locomotion0.10.10.2-0.3-0.3-0.3-0.30.2-0.3-0.30.3-0.3-0.3-0.3-0.2-0.20.2-0.3-0.3-0.2-0.2-0.3-0.3-0.3-0.3-0.20.5-0.5
Cocaine response after cond. corrected0.50.60.80.60.60.70.8-0.80.70.7-0.70.70.70.70.80.9-0.90.80.80.80.80.80.90.80.90.9-0.50.4
Cocaine response after cond. not corrected1.31.51.91.11.11.21.3-1.31.21.2-1.21.21.21.21.31.4-1.41.21.31.21.31.31.31.31.31.2-0.90.9
Cocaine response before conditioning1.62.02.41.61.41.41.5-1.41.41.4-1.41.41.41.41.41.5-1.51.41.41.41.51.41.31.31.21.0-1.31.3
Saline control response1.92.53.31.31.51.61.8-1.81.61.6-1.61.61.61.61.71.5-1.51.71.71.71.51.71.71.71.71.80.0-0.2
Bone: connectivity density0.10.10.30.40.1-0.0-0.40.3-0.0-0.10.1-0.1-0.1-0.1-0.3-0.20.2-0.2-0.3-0.2-0.0-0.3-0.3-0.3-0.60.50.5-0.5
Bone: cortical apparent density0.00.10.2-0.1-0.3-0.3-0.30.4-0.3-0.30.3-0.2-0.3-0.3-0.4-0.20.2-0.3-0.2-0.3-0.2-0.3-0.4-0.1-0.3-0.40.1-0.0
Bone: cortical area1.62.43.11.81.61.71.6-1.61.61.6-1.61.61.61.61.61.5-1.51.61.61.61.51.61.61.51.41.4-1.21.1
Bone: cortical porosity0.10.10.2-0.3-0.3-0.3-0.40.4-0.3-0.30.3-0.3-0.3-0.3-0.4-0.40.4-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.20.10.3-0.3
Bone: cortical porosity0.00.00.10.10.20.10.1-0.10.10.1-0.10.10.10.10.0-0.00.00.10.10.1-0.00.10.10.10.10.3-0.00.0
Bone: cortical thickness0.50.91.01.01.01.01.0-1.01.01.0-1.01.01.01.01.01.0-1.01.01.01.01.01.00.90.90.90.8-0.70.7
Bone: cortical thickness1.31.52.01.01.21.21.4-1.41.31.3-1.21.31.31.31.41.2-1.21.31.31.31.21.41.21.31.31.0-0.20.1
Bone: cortical tissue density0.10.10.3-0.2-0.4-0.4-0.40.5-0.4-0.40.4-0.4-0.4-0.4-0.5-0.30.3-0.4-0.3-0.4-0.3-0.4-0.5-0.3-0.4-0.50.1-0.0
Condit. Reinf. active minus inactive responses0.50.51.00.91.00.80.8-0.70.80.8-0.80.80.80.80.70.8-0.80.70.90.70.90.70.50.80.50.4-0.40.4
Condit. Reinf. active-inactive response ratio0.40.40.80.80.90.70.7-0.50.70.7-0.70.70.60.70.50.7-0.70.60.70.60.70.60.30.70.50.5-0.20.2
Condit. Reinf. active responses0.30.30.60.80.80.60.5-0.50.60.6-0.60.60.60.60.50.7-0.70.50.60.50.70.50.30.60.30.3-0.40.4
Condit. Reinf. inactive responses0.10.10.2-0.2-0.3-0.3-0.50.4-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.4-0.3-0.3-0.4-0.3-0.4-0.5-0.20.2-0.1
Incentive salience index mean0.40.40.90.91.00.70.6-0.50.70.7-0.70.70.70.70.50.8-0.80.60.70.60.80.60.40.60.30.5-0.30.3
Condit. Reinf. lever presses0.10.10.40.60.60.40.2-0.10.40.3-0.30.30.30.30.10.4-0.40.20.30.20.40.20.10.2-0.10.3-0.10.1
Condit. Reinf. active minus inactive responses0.00.10.10.20.20.20.3-0.30.20.2-0.20.20.20.20.30.2-0.20.20.30.20.20.20.20.30.30.1-0.30.3
Condit. Reinf. active-inactive response ratio0.20.30.60.30.30.50.6-0.60.50.5-0.50.50.50.50.60.4-0.40.50.50.50.40.60.60.70.80.5-0.20.2
Condit. Reinf. active responses0.10.10.3-0.2-0.3-0.3-0.30.3-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.2-0.3-0.3-0.3-0.4-0.2-0.3-0.6-0.00.1
Condit. Reinf. inactive responses0.60.71.5-0.7-0.8-0.9-0.90.9-0.9-0.90.9-0.9-0.9-0.9-0.9-0.80.8-0.9-0.8-0.9-0.8-0.9-1.0-0.9-1.0-1.20.2-0.1
Condit. Reinf. lever presses0.10.10.30.50.50.40.3-0.40.40.4-0.40.40.40.40.40.3-0.30.40.40.40.30.30.30.40.20.2-0.30.3
Condit. Reinf. lever reinforcers received0.10.10.4-0.3-0.3-0.4-0.40.4-0.4-0.40.4-0.4-0.4-0.4-0.3-0.40.4-0.4-0.3-0.4-0.4-0.4-0.4-0.3-0.4-0.60.10.0
Conditioned reinforcement - actives1.32.34.32.02.11.81.5-1.51.71.7-1.71.71.71.71.41.3-1.31.61.41.61.31.41.41.41.21.6-0.1-0.1
Conditioned reinforcement - inactives0.71.02.91.71.51.20.8-0.81.21.2-1.11.11.11.10.80.9-0.91.00.81.00.90.80.80.80.30.9-0.60.4
Conditioned locomotion1.92.43.51.41.41.61.7-1.71.61.6-1.61.61.61.61.71.6-1.61.71.61.61.61.71.71.71.91.30.0-0.1
Patch foraging indifference point 0 sec0.40.71.60.50.50.70.9-0.80.70.7-0.70.70.70.70.80.6-0.60.80.80.80.70.90.90.91.10.6-1.21.2
Patch foraging indifference point AUC3.44.96.52.52.52.32.2-2.32.32.3-2.32.32.32.32.32.5-2.52.22.42.22.52.12.22.11.82.3-0.40.3
Delay disc. indifference point, 0s delay0.80.91.7-0.5-0.5-0.9-1.11.2-0.9-0.90.9-0.9-0.9-0.9-1.2-1.01.0-1.0-1.0-1.0-1.0-1.1-1.2-1.2-1.3-0.70.2-0.3
Delay disc. indifference point, 16s delay0.80.91.5-0.6-0.5-0.9-1.11.1-0.9-0.90.9-0.9-0.9-0.9-1.1-1.01.0-1.0-1.2-1.0-1.0-1.1-1.2-1.0-1.2-0.50.7-0.8
Delay disc. indifference point, 2s delay2.83.14.7-1.3-1.2-1.6-2.01.9-1.7-1.71.7-1.7-1.7-1.7-1.9-1.81.8-1.8-2.0-1.8-1.7-1.9-2.1-1.8-2.2-1.51.7-1.8
Delay disc. indifference point, 24s delay0.00.00.3-0.10.00.10.2-0.20.10.1-0.10.10.10.10.2-0.00.00.10.10.10.00.2-0.00.00.20.6-0.20.1
Delay disc. indifference point, 4s delay0.10.10.90.50.40.1-0.0-0.00.10.1-0.10.10.10.10.00.1-0.10.0-0.10.00.2-0.0-0.1-0.0-0.1-0.4-0.90.8
Delay disc. indifference point, 8s delay1.31.51.8-1.2-1.2-1.3-1.31.3-1.3-1.31.3-1.3-1.3-1.3-1.3-1.21.2-1.4-1.3-1.3-1.1-1.4-1.4-1.3-1.3-1.10.4-0.3
Indifference point function ln k1.12.03.6-1.9-1.9-1.6-1.21.3-1.6-1.51.5-1.5-1.5-1.5-1.3-1.71.7-1.4-1.4-1.4-1.8-1.1-1.2-1.2-0.6-1.60.00.2
Indifference point function log k1.12.03.6-1.9-1.9-1.6-1.21.3-1.6-1.51.5-1.5-1.5-1.5-1.3-1.71.7-1.4-1.4-1.4-1.8-1.1-1.2-1.2-0.6-1.60.00.2
Patch foraging total patch changes 0 sec0.50.92.00.50.60.91.1-1.00.80.9-0.90.90.90.91.00.8-0.81.00.91.00.81.11.11.11.40.7-1.31.3
Patch foraging total patch changes 12 sec1.72.23.31.71.81.61.5-1.51.61.6-1.61.61.61.61.51.6-1.61.51.61.51.71.41.41.31.11.3-0.50.3
Patch foraging total patch changes 18 sec1.92.94.01.61.71.71.8-1.81.71.7-1.71.71.71.71.82.0-2.01.71.91.72.01.81.81.61.91.8-0.80.8
Patch foraging total patch changes 24 sec0.50.81.41.21.10.90.8-0.70.90.9-0.90.90.90.90.71.1-1.10.81.00.81.10.80.70.60.61.10.4-0.5
Patch foraging total patch changes 6 sec2.33.53.91.91.81.92.0-1.91.91.9-1.91.91.91.92.01.9-1.91.91.91.91.91.92.01.91.91.8-1.41.3
Patch foraging time to switch 0 sec2.04.15.1-1.9-1.7-2.1-2.22.3-2.1-2.12.1-2.1-2.1-2.1-2.3-2.12.1-2.2-2.1-2.1-2.0-2.2-2.2-2.1-2.2-2.20.8-0.6
Patch foraging water rate 0 sec2.45.16.22.12.02.32.5-2.52.32.3-2.32.32.32.32.52.3-2.32.42.32.42.22.42.42.42.42.1-1.11.0
Patch foraging water rate 12 sec0.10.20.40.30.30.40.5-0.40.40.4-0.40.40.40.40.40.3-0.30.40.50.40.20.50.40.40.40.6-0.00.0
Patch foraging water rate 18 sec0.10.10.20.30.20.40.4-0.40.30.4-0.30.30.30.30.30.0-0.00.40.10.4-0.00.40.30.30.30.1-0.10.1
Patch foraging water rate 24 sec0.30.50.90.30.40.60.9-0.90.60.6-0.60.70.70.60.90.8-0.80.70.90.70.60.90.80.81.00.6-0.00.0
Patch foraging water rate 6 sec0.50.81.21.10.91.00.9-0.91.01.0-1.00.90.90.90.90.8-0.80.90.90.90.80.90.80.90.81.00.1-0.3
Seeking ratio, delayed vs. immediate footshock2.02.43.4-1.7-1.7-1.6-1.51.6-1.6-1.61.6-1.6-1.6-1.6-1.6-1.31.3-1.6-1.5-1.6-1.4-1.5-1.5-1.5-1.3-1.61.8-1.7
Distance traveled before self-admin0.00.00.10.00.20.20.2-0.20.20.2-0.20.20.20.20.30.0-0.00.2-0.10.2-0.00.20.20.30.40.1-0.20.2
Distance traveled after self-admin0.30.30.6-0.8-0.6-0.6-0.50.5-0.6-0.60.6-0.6-0.5-0.6-0.5-0.70.7-0.5-0.7-0.5-0.8-0.5-0.5-0.5-0.4-0.70.6-0.6
Extensor digitorum longus weight2.08.09.53.02.92.92.8-2.82.92.9-2.92.92.82.92.72.8-2.82.82.72.82.92.82.72.62.72.5-3.12.9
Bone: elastic displacement0.70.81.2-1.0-0.9-1.0-0.81.0-1.0-1.01.0-0.9-1.0-1.0-1.1-0.80.8-0.9-0.8-0.9-0.7-0.8-1.0-0.9-0.6-0.80.3-0.2
Bone: elastic work0.10.10.80.30.50.30.3-0.20.30.3-0.30.30.30.30.20.3-0.30.20.40.20.30.30.10.20.2-0.1-0.80.9
Bone: endosteal estimation0.00.00.20.00.2-0.1-0.20.2-0.1-0.10.1-0.1-0.1-0.1-0.2-0.20.2-0.2-0.2-0.2-0.2-0.3-0.2-0.3-0.50.00.2-0.3
Bone: endosteal perimeter0.00.00.30.40.30.2-0.00.10.10.1-0.10.10.10.1-0.0-0.00.00.00.00.1-0.1-0.00.1-0.0-0.20.3-0.60.4
Epididymis fat weight0.20.51.1-0.5-0.4-0.7-0.80.9-0.7-0.70.7-0.7-0.7-0.7-0.9-0.80.8-0.8-0.6-0.7-0.6-0.8-0.8-0.8-1.0-0.80.7-0.5
Delta time in closed arm before/after self-admin0.30.30.8-0.8-0.8-0.6-0.40.4-0.6-0.60.6-0.5-0.5-0.6-0.4-0.50.5-0.5-0.6-0.5-0.9-0.3-0.4-0.3-0.1-0.9-0.40.5
Delta time in open arm before/after self-admin0.10.10.80.50.40.2-0.20.10.10.1-0.10.10.10.1-0.10.2-0.2-0.00.1-0.00.5-0.2-0.1-0.2-0.60.10.8-0.9
Diff in mean of infusions in LGA sessions1.51.83.6-1.7-1.6-1.5-1.21.3-1.4-1.41.4-1.4-1.4-1.4-1.2-1.01.0-1.3-1.1-1.3-1.0-1.3-1.2-1.3-1.0-1.21.9-1.8
Delay discount exponential model param0.91.01.70.70.71.01.1-1.11.01.0-1.01.01.01.01.11.1-1.11.11.21.11.01.11.31.11.20.9-0.50.6
Extinction: sum of active levers before priming0.10.10.6-0.2-0.1-0.2-0.00.1-0.2-0.20.2-0.2-0.2-0.2-0.10.1-0.1-0.20.1-0.20.0-0.2-0.1-0.2-0.2-0.2-0.70.8
Active lever presses in extinction session 60.20.20.50.50.70.40.4-0.40.40.4-0.40.40.40.40.30.3-0.30.40.50.40.40.30.40.20.30.4-0.70.6
Bone: final force0.50.71.21.01.10.90.8-0.80.90.9-0.90.90.90.90.80.9-0.90.80.90.80.90.80.80.70.61.0-0.70.6
Bone: final moment0.71.11.71.21.31.11.0-1.01.11.1-1.11.11.11.11.01.1-1.11.01.01.01.01.00.90.90.71.1-1.00.8
Food consumed during 24 hour testing period5.17.010.0-2.7-2.7-2.7-2.82.8-2.7-2.72.7-2.7-2.7-2.7-2.8-2.62.6-2.7-2.6-2.7-2.7-2.7-2.7-2.7-2.7-3.21.5-1.2
Glucose0.30.51.0-0.9-0.8-0.8-0.60.6-0.7-0.70.7-0.7-0.7-0.7-0.6-0.70.7-0.7-0.6-0.6-0.7-0.6-0.6-0.5-0.4-0.81.0-0.9
Heart weight1.92.93.81.51.51.71.9-2.01.71.7-1.71.71.71.72.01.6-1.61.81.71.81.61.91.91.81.91.0-1.31.2
Delay discount hyperbolic model param0.80.91.50.60.60.91.1-1.00.90.9-0.91.01.01.01.01.0-1.01.01.21.00.91.11.21.01.20.9-0.50.5
Intermittent access intake day 1-15 change0.10.20.70.50.60.50.4-0.40.50.4-0.50.40.40.50.40.3-0.30.40.40.40.30.30.30.30.30.8-0.10.1
Intermittent access intake escalation0.10.31.00.70.80.60.5-0.50.60.6-0.60.60.60.60.50.4-0.40.50.50.50.40.40.40.40.31.0-0.10.1
Intermittent access intake escalation 20.00.00.2-0.2-0.0-0.10.1-0.0-0.1-0.10.0-0.0-0.0-0.00.1-0.00.0-0.00.1-0.0-0.00.00.00.00.30.4-0.30.4
Intermitt. access day 1 inactive lever presses0.10.33.50.60.40.30.0-0.10.30.3-0.30.20.20.20.10.4-0.40.20.20.20.30.00.00.0-0.20.5-1.91.7
Intermitt. access day 15 inactive lever presses0.00.10.80.60.10.2-0.20.20.20.2-0.20.20.10.1-0.10.3-0.30.10.20.10.5-0.00.00.1-0.20.90.2-0.2
Intermitt. access escalation Index0.20.30.8-0.8-0.9-0.6-0.50.5-0.6-0.60.6-0.6-0.6-0.6-0.5-0.40.4-0.6-0.5-0.6-0.4-0.5-0.5-0.5-0.4-0.5-0.10.2
Intermittent access day 1 total infusions1.72.74.92.22.11.91.6-1.61.81.8-1.81.81.81.81.61.7-1.71.71.71.71.51.61.51.61.11.50.1-0.3
Intermittent access day 15 total infusions0.91.32.11.51.41.21.1-1.11.31.2-1.21.21.21.21.11.3-1.31.11.21.21.21.01.01.00.71.20.4-0.5
Intermittent access terminal intake (last 3 days)1.11.52.01.41.41.31.3-1.31.31.3-1.31.31.31.31.31.4-1.41.21.31.31.31.21.11.21.01.1-0.10.0
Intermittent access total infusions2.52.93.91.91.81.81.8-1.81.81.8-1.81.81.81.81.82.0-2.01.81.81.81.81.71.71.71.41.5-0.40.3
Intermittent access day 1 locomotion0.30.41.21.10.80.80.6-0.60.80.8-0.70.70.70.70.60.8-0.80.70.60.70.70.60.60.60.20.40.1-0.2
Intermittent access day 15 total locomotion0.20.31.10.70.60.50.5-0.50.60.5-0.50.50.50.50.50.3-0.30.50.50.50.30.50.50.50.20.31.1-1.1
Intermittent access total locomotion1.51.82.71.61.31.51.4-1.41.51.5-1.41.51.51.41.41.4-1.41.41.41.41.31.41.41.41.11.10.0-0.1
Intermittent access standard deviation0.10.20.2-0.5-0.5-0.5-0.50.5-0.5-0.50.5-0.5-0.5-0.5-0.4-0.30.3-0.5-0.4-0.5-0.3-0.5-0.5-0.4-0.4-0.2-0.00.1
Left kidney weight5.424.929.85.35.55.25.2-5.25.25.2-5.25.25.25.25.25.2-5.25.15.15.15.24.94.94.94.43.8-4.13.8
Right kidney weight5.022.825.64.95.04.95.0-5.04.94.9-4.94.94.94.95.05.1-5.14.84.94.95.14.84.74.64.34.0-3.93.6
Cocaine induced anxiety0.10.10.3-0.0-0.1-0.2-0.40.5-0.3-0.30.3-0.3-0.3-0.3-0.5-0.20.2-0.4-0.4-0.4-0.1-0.4-0.4-0.4-0.5-0.10.4-0.5
Post-drug Anxiety0.00.00.2-0.1-0.2-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.0-0.1-0.1-0.1-0.1-0.10.0-0.10.4-0.5
Baseline Anxiety0.20.21.0-1.0-1.0-0.50.0-0.1-0.5-0.40.4-0.4-0.4-0.40.1-0.20.2-0.20.0-0.2-0.40.00.00.00.6-0.70.20.2
Tail length0.62.24.22.11.91.61.3-1.21.61.6-1.51.51.51.51.21.3-1.31.41.31.41.51.21.21.20.91.5-1.91.6
Length with tail0.52.03.51.91.81.51.3-1.31.51.5-1.51.51.51.51.21.4-1.41.31.31.31.51.21.21.10.91.2-1.61.4
Length without tail0.41.11.71.21.21.11.0-1.01.11.1-1.11.11.11.11.01.3-1.31.01.11.01.31.01.00.90.80.5-1.21.2
Times rat made contact with spout0.10.10.4-0.6-0.5-0.3-0.20.2-0.3-0.30.3-0.3-0.3-0.3-0.1-0.20.2-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.0-0.50.2-0.1
Lifetime Intake2.53.14.32.12.01.91.8-1.81.91.9-1.91.91.91.91.82.0-2.01.81.91.81.91.71.71.71.41.5-0.40.3
Liver weight, left2.33.85.02.12.22.12.1-2.02.12.1-2.12.12.12.12.01.9-1.92.02.02.01.92.02.01.91.91.6-1.10.9
Liver weight, right1.62.84.22.02.11.81.8-1.71.81.8-1.81.71.71.71.61.8-1.81.61.81.61.81.61.41.51.21.4-1.51.2
Locomotor activity2.03.14.01.61.71.81.9-2.01.81.8-1.81.81.81.82.01.6-1.61.81.91.81.61.91.91.91.91.2-1.61.4
Locomotor testing distance1.11.92.61.41.61.51.4-1.51.51.5-1.41.51.51.51.51.2-1.21.51.41.51.21.41.61.51.30.9-1.00.8
Locomotor testing rearing4.28.510.73.13.33.13.0-3.13.13.1-3.13.13.13.03.12.9-2.93.03.03.03.02.93.03.02.72.5-1.91.6
Locomotion in novel chamber0.40.51.4-1.2-1.2-0.8-0.50.4-0.8-0.80.7-0.7-0.7-0.7-0.4-0.70.7-0.6-0.6-0.6-0.9-0.5-0.5-0.5-0.2-0.90.6-0.3
Locomotion in novel chamber post-restriction0.91.52.6-1.3-1.2-1.3-1.31.4-1.3-1.21.3-1.3-1.2-1.3-1.4-1.31.3-1.2-1.3-1.2-1.3-1.2-1.1-1.1-1.2-1.60.4-0.4
Fecal boli incidents, locomotor time 10.10.21.40.40.30.40.3-0.40.30.3-0.30.30.30.30.30.2-0.20.30.20.30.20.20.30.30.2-0.6-1.21.1
Change in fecal boli incidents, locomotor task0.60.61.0-0.9-0.6-0.8-0.90.9-0.8-0.80.8-0.8-0.8-0.8-0.9-0.70.7-0.8-0.8-0.8-0.7-0.9-0.9-1.0-1.0-0.10.4-0.5
Time >=10cm from walls, locomotor time 10.10.10.5-0.3-0.1-0.1-0.00.1-0.1-0.10.1-0.1-0.0-0.1-0.1-0.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.7-0.60.6
Bouts of movement, locomotor time 12.52.83.9-2.0-1.7-1.8-1.61.7-1.8-1.81.8-1.8-1.7-1.8-1.7-1.61.6-1.7-1.6-1.7-1.5-1.6-1.7-1.7-1.6-1.61.3-1.2
Total resting periods, locomotor time 13.23.64.4-2.1-1.9-2.0-1.91.9-2.0-2.02.0-2.0-1.9-2.0-1.9-1.81.8-1.9-1.8-1.9-1.6-1.9-1.9-2.0-1.9-1.81.6-1.5
Rest time, locomotor task time 10.20.20.4-0.5-0.5-0.5-0.50.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.40.4-0.5-0.5-0.5-0.3-0.5-0.4-0.6-0.6-0.30.4-0.4
Distance moved, locomotor task time 10.50.71.30.90.90.80.8-0.80.80.8-0.80.80.80.80.80.8-0.80.80.80.80.80.80.70.80.80.6-1.11.1
Vertical activity count, locomotor time 10.00.00.20.30.50.20.1-0.10.20.2-0.20.20.20.20.10.1-0.10.10.10.10.10.00.0-0.0-0.1-0.0-0.50.5
Time >=10cm from walls, locomotor time 20.00.10.20.00.0-0.2-0.40.3-0.2-0.20.2-0.2-0.2-0.2-0.3-0.30.3-0.2-0.3-0.2-0.4-0.3-0.2-0.2-0.4-0.4-0.20.2
Bouts of movement, locomotor time 24.77.58.7-2.8-2.9-2.9-2.82.8-2.9-2.92.9-2.9-2.9-2.9-2.8-2.72.7-2.8-2.7-2.8-2.6-2.7-2.8-2.7-2.4-2.32.5-2.2
Total resting periods, locomotor time 23.96.88.5-2.8-2.9-2.8-2.72.7-2.8-2.82.8-2.8-2.8-2.7-2.6-2.52.5-2.7-2.6-2.7-2.4-2.6-2.7-2.5-2.2-2.32.4-2.0
Rest time, locomotor task time 20.10.10.7-0.6-0.8-0.5-0.30.4-0.5-0.40.5-0.4-0.4-0.4-0.3-0.10.1-0.3-0.2-0.3-0.0-0.2-0.2-0.2-0.1-0.50.10.0
Distance moved, locomotor task time 20.91.12.31.21.31.11.0-1.11.11.1-1.11.11.11.11.10.9-0.91.01.01.00.91.00.91.00.91.5-0.50.4
Vertical activity count, locomotor time 20.00.00.20.30.50.1-0.10.00.10.1-0.10.00.00.0-0.1-0.20.2-0.1-0.1-0.1-0.2-0.2-0.2-0.3-0.50.3-0.20.1
Light reinforcement 10.00.10.20.30.40.40.3-0.30.30.4-0.30.30.30.30.30.2-0.20.30.30.30.30.30.40.30.3-0.10.1-0.1
Light reinforcement 20.20.30.90.91.00.70.2-0.30.60.6-0.60.50.50.50.30.5-0.50.40.30.40.60.20.40.2-0.20.4-0.40.1
Bone: marrow area0.00.00.10.10.20.0-0.10.1-0.0-0.00.0-0.0-0.0-0.0-0.2-0.10.1-0.1-0.1-0.1-0.1-0.2-0.1-0.2-0.40.10.1-0.2
Bone: maximum diameter2.34.35.02.22.22.22.2-2.12.22.1-2.22.12.12.22.12.1-2.12.12.22.12.12.12.12.01.92.0-1.71.5
Bone: maximum force0.20.40.70.80.90.70.5-0.50.70.6-0.60.60.60.60.50.6-0.60.60.60.60.60.50.50.40.20.6-0.70.7
Bone: maximum moment0.30.61.01.01.00.80.6-0.60.80.8-0.80.80.80.80.60.7-0.70.70.70.70.70.60.60.50.30.8-1.00.9
Mean time between licks in bursts0.00.10.2-0.0-0.1-0.2-0.30.3-0.2-0.20.2-0.2-0.2-0.2-0.3-0.10.1-0.2-0.1-0.2-0.1-0.3-0.3-0.3-0.4-0.1-0.50.5
Mean num. licks in bursts3.24.96.1-2.5-2.2-2.3-2.22.2-2.3-2.32.3-2.3-2.2-2.3-2.2-2.22.2-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.1-2.02.2-2.1
Cd content in liver0.20.20.5-0.7-0.7-0.5-0.30.2-0.5-0.50.4-0.4-0.4-0.4-0.3-0.20.2-0.4-0.3-0.4-0.2-0.3-0.3-0.3-0.1-0.50.6-0.5
Co content in liver1.21.42.0-1.2-1.4-1.2-1.31.3-1.2-1.21.2-1.2-1.2-1.2-1.3-1.01.0-1.2-1.0-1.2-1.0-1.2-1.2-1.2-1.2-1.30.5-0.3
Cu content in liver0.40.51.10.80.70.70.7-0.70.70.7-0.70.70.70.70.70.8-0.80.70.80.70.80.70.70.60.71.00.0-0.1
Fe content in liver4.65.57.32.12.02.32.6-2.52.32.4-2.42.42.42.42.62.5-2.52.52.52.52.52.62.52.62.71.9-1.41.3
K content in liver0.30.30.60.60.80.60.5-0.50.60.6-0.60.60.60.50.50.4-0.40.50.40.50.40.50.50.40.30.4-0.60.5
Mg content in liver0.70.71.30.91.10.90.9-0.90.90.9-0.90.90.90.90.90.8-0.80.90.80.90.80.80.80.80.60.6-0.90.8
Mn content in liver1.11.21.81.21.31.21.1-1.11.11.1-1.11.11.11.11.11.1-1.11.11.11.11.11.01.01.00.81.0-1.00.9
Na content in liver0.10.20.7-0.1-0.00.30.5-0.60.30.3-0.30.40.40.30.50.2-0.20.50.30.40.20.60.60.40.80.2-0.10.2
Rb content in liver0.10.10.20.10.30.20.3-0.30.20.2-0.20.20.20.20.30.1-0.10.20.20.20.10.30.30.20.3-0.1-0.40.4
Se content in liver4.14.95.92.42.42.42.3-2.32.32.3-2.32.32.32.32.22.2-2.22.32.32.32.22.22.22.22.12.4-1.10.8
Sr content in liver0.10.10.20.30.20.20.2-0.20.20.2-0.20.20.20.20.20.2-0.20.20.20.20.20.20.20.20.20.4-0.10.1
Zn content in liver1.01.12.31.31.31.21.0-1.01.11.1-1.11.11.11.10.91.0-1.01.11.01.01.01.01.00.90.91.5-0.90.7
Bone: minimum diameter0.20.40.80.90.70.70.6-0.60.70.7-0.70.60.60.70.50.5-0.50.60.50.60.50.60.60.50.40.7-0.80.7
Time in familiar zone, hab. session 10.20.20.60.30.30.30.4-0.40.30.3-0.30.30.40.30.40.2-0.20.40.30.40.20.40.50.40.50.2-0.80.7
Time in novel zone, hab. session 10.70.71.60.90.80.90.9-0.80.90.9-0.90.90.90.90.81.0-1.00.80.90.81.00.80.70.80.81.30.3-0.4
Total zone transitions, hab. session 10.10.10.20.10.30.30.4-0.40.30.3-0.30.30.30.30.40.2-0.20.30.30.40.20.40.40.40.50.10.2-0.2
Total locomotion distance, hab. session 10.40.60.7-0.7-0.6-0.7-0.80.8-0.7-0.70.7-0.7-0.7-0.7-0.8-0.80.8-0.7-0.7-0.7-0.8-0.7-0.8-0.7-0.7-0.60.8-0.7
Locomotion velocity, hab. session 11.21.71.9-1.3-1.1-1.3-1.41.4-1.3-1.31.3-1.3-1.3-1.3-1.4-1.41.4-1.3-1.3-1.3-1.4-1.3-1.4-1.3-1.3-1.30.9-0.8
Time in familiar zone, hab. session 20.40.40.50.60.70.60.7-0.60.60.6-0.60.60.60.60.60.7-0.70.60.60.60.70.70.60.70.70.7-0.40.3
Time in novel zone, hab. session 20.20.20.4-0.6-0.6-0.4-0.30.3-0.4-0.40.4-0.4-0.4-0.4-0.3-0.50.5-0.3-0.4-0.3-0.5-0.3-0.3-0.3-0.1-0.40.6-0.5
Total zone transitions, hab. session 20.40.60.90.60.70.80.9-0.90.80.8-0.80.80.80.80.90.7-0.70.80.80.80.70.90.90.81.00.6-0.30.3
Total locomotion distance, hab. session 20.50.60.8-0.9-0.8-0.8-0.80.8-0.8-0.80.8-0.8-0.8-0.8-0.8-0.90.9-0.8-0.8-0.8-0.9-0.7-0.8-0.7-0.7-0.80.7-0.7
Locomotion velocity, hab. session 20.30.40.6-0.7-0.5-0.6-0.70.7-0.6-0.60.6-0.6-0.6-0.6-0.7-0.80.8-0.6-0.7-0.7-0.8-0.6-0.7-0.6-0.6-0.70.5-0.5
Novel to familiar place preference ratio0.30.40.90.80.70.70.5-0.60.70.7-0.70.60.60.70.60.5-0.50.60.40.60.50.50.60.50.40.90.1-0.2
Novelty place preference0.30.30.70.70.60.60.4-0.60.60.6-0.60.60.60.60.60.4-0.40.60.30.60.40.50.60.50.40.80.2-0.3
Time in novel zone, NPP test0.40.40.90.80.60.70.5-0.70.70.7-0.70.70.70.70.70.5-0.50.70.50.70.50.60.70.60.61.00.2-0.3
Total zone transitions, NPP test0.10.10.20.30.40.30.4-0.40.30.3-0.30.30.30.30.40.2-0.20.30.40.40.20.40.40.30.40.3-0.10.1
Total locomotion distance, NPP test0.00.10.20.10.20.20.3-0.30.20.2-0.20.20.20.20.30.1-0.10.30.30.30.10.30.40.30.40.30.2-0.2
Locomotion velocity, NPP test0.00.00.10.10.20.20.2-0.30.20.2-0.20.20.20.20.30.1-0.10.20.20.20.00.20.30.20.30.10.0-0.0
Intraocular pressure0.10.21.3-0.3-0.4-0.3-0.00.1-0.2-0.30.2-0.2-0.2-0.2-0.1-0.10.1-0.10.0-0.1-0.2-0.0-0.10.10.3-1.1-0.81.1
Delta distance traveled before/after self-admin1.51.63.1-0.9-0.9-1.1-1.41.4-1.1-1.11.2-1.2-1.2-1.2-1.4-1.31.3-1.3-1.2-1.3-1.2-1.4-1.3-1.4-1.7-1.01.2-1.2
Delta ambulatory time before/after self-admin0.30.40.8-0.3-0.4-0.5-0.70.7-0.5-0.50.6-0.6-0.6-0.6-0.7-0.80.8-0.6-0.6-0.6-0.7-0.7-0.6-0.7-0.9-0.40.8-0.8
Parametrial fat weight0.10.20.30.20.40.40.5-0.50.40.4-0.40.40.40.40.50.5-0.50.40.50.40.40.40.30.30.2-0.00.5-0.5
Pavlov. Cond. lever latency0.50.70.9-0.7-0.9-0.8-0.90.8-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.8-0.8-0.9-0.8-0.9-0.9-0.7-0.9-0.9-0.9-0.20.3
Pavlov. Cond. magazine entry latency0.10.20.40.50.60.40.4-0.30.40.4-0.40.40.40.40.30.4-0.40.30.40.40.40.40.20.40.30.40.4-0.6
Pavlov. Cond. change in total contacts0.60.61.0-0.7-0.6-0.8-0.80.9-0.8-0.80.8-0.8-0.8-0.8-0.8-0.70.7-0.8-0.8-0.8-0.7-0.8-0.9-0.7-0.8-0.81.0-0.9
Pavlov. Cond. index score0.30.40.50.60.70.60.7-0.60.60.6-0.60.60.60.60.60.6-0.60.60.60.60.60.70.50.70.60.60.3-0.4
Pavlov. Cond. latency score0.10.10.40.30.40.30.4-0.30.30.3-0.30.30.30.30.20.3-0.30.30.40.30.40.40.20.40.30.30.6-0.6
Pavlov. Cond. lever contacts0.40.40.60.50.70.70.8-0.60.70.7-0.70.70.70.70.60.7-0.70.60.70.70.70.70.50.70.70.70.2-0.3
Pavlov. Cond. magazine entry number0.10.10.6-0.3-0.4-0.2-0.30.1-0.2-0.20.2-0.2-0.2-0.2-0.1-0.20.2-0.2-0.3-0.2-0.2-0.3-0.0-0.3-0.2-0.2-0.70.8
Pavlov. Cond. intertrial magazine entries0.10.10.50.1-0.00.10.2-0.30.20.1-0.20.20.20.20.30.4-0.40.20.30.20.40.20.30.20.2-0.0-0.60.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.60.70.60.7-0.60.60.6-0.60.60.60.60.60.6-0.60.60.70.60.70.70.50.80.70.60.2-0.3
Pavlov. Cond. response bias0.91.11.61.21.31.11.2-1.01.11.1-1.11.11.11.11.01.1-1.11.11.11.11.11.10.91.21.01.0-0.0-0.1
Pavlov. Cond. lever latency0.00.10.4-0.4-0.2-0.2-0.10.1-0.2-0.20.2-0.2-0.2-0.2-0.1-0.10.1-0.1-0.2-0.1-0.1-0.1-0.1-0.10.00.20.7-0.6
Pavlov. Cond. magazine entry latency0.00.00.40.00.10.00.0-0.10.00.0-0.00.00.00.00.10.1-0.10.00.10.00.2-0.0-0.00.0-0.1-0.4-0.50.6
Pavlov. Cond. change in total contacts0.20.41.0-0.6-0.7-0.6-0.60.5-0.6-0.60.6-0.6-0.6-0.6-0.5-0.70.7-0.6-0.6-0.6-0.7-0.6-0.6-0.6-0.5-1.00.10.0
Pavlov. Cond. index score0.10.10.4-0.1-0.1-0.2-0.30.2-0.2-0.20.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.1-0.2-0.2-0.3-0.2-0.2-0.4-0.6-0.60.6
Pavlov. Cond. latency score0.10.10.5-0.2-0.2-0.3-0.40.3-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.2-0.3-0.3-0.4-0.3-0.3-0.5-0.7-0.40.5
Pavlov. Cond. lever contacts0.10.20.70.60.50.40.3-0.30.40.4-0.40.30.30.40.30.3-0.30.30.40.30.30.20.20.30.1-0.0-0.90.8
Pavlov. Cond. magazine entry number0.40.41.30.60.50.60.7-0.70.60.6-0.60.70.60.70.60.6-0.60.70.60.70.60.80.70.70.81.10.0-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.20.1-0.10.00.1-0.10.00.0-0.00.00.00.00.1-0.00.00.10.00.1-0.00.10.10.10.30.40.4-0.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.40.10.10.0-0.10.0-0.0-0.00.0-0.0-0.0-0.00.0-0.00.0-0.00.0-0.0-0.0-0.1-0.1-0.0-0.2-0.5-0.60.6
Pavlov. Cond. response bias0.10.10.70.20.1-0.0-0.10.0-0.0-0.00.0-0.0-0.0-0.0-0.0-0.00.0-0.10.0-0.1-0.1-0.1-0.1-0.1-0.2-0.5-0.80.8
Time in closed arm before self-admin0.70.81.40.90.91.00.9-1.01.01.0-1.00.90.91.01.01.0-1.00.91.00.91.20.90.90.90.91.0-0.1-0.1
Time in closed arm after self-admin1.11.22.1-1.4-1.4-1.2-1.01.0-1.2-1.11.1-1.1-1.1-1.1-1.0-1.11.1-1.0-1.1-1.1-1.2-1.0-1.0-0.9-0.6-1.20.9-0.8
Time in open arm before self-admin0.70.71.4-0.8-0.7-0.9-0.70.9-0.9-0.90.9-0.9-0.9-0.9-0.9-1.11.1-0.9-1.0-0.9-1.2-0.8-0.8-0.8-0.7-1.1-0.30.4
Time in open arm after self-admin0.10.10.40.30.3-0.1-0.20.2-0.1-0.10.1-0.1-0.1-0.1-0.3-0.10.1-0.2-0.1-0.20.2-0.3-0.2-0.3-0.6-0.1-0.50.5
Bone: periosteal estimation0.30.61.11.01.00.90.8-0.70.90.8-0.80.80.80.80.70.7-0.70.80.80.80.60.70.80.60.50.8-0.60.4
Bone: periosteal perimeter0.40.61.31.21.10.90.7-0.60.90.8-0.90.80.80.80.60.7-0.70.80.70.80.60.70.70.70.41.0-0.90.7
Bone: post-yield work0.71.02.2-0.4-0.6-0.8-1.31.2-0.9-0.90.9-0.9-0.9-0.9-1.2-1.01.0-1.0-1.1-1.0-1.0-1.2-1.1-1.1-1.5-0.70.2-0.2
Progressive ratio test 1 active lever presses2.83.55.82.42.32.11.9-1.92.12.1-2.02.02.02.01.81.8-1.81.91.91.91.81.81.81.81.41.8-0.70.4
Progressive ratio test 1 breakpoint2.63.25.32.32.32.01.8-1.82.02.0-1.91.91.91.91.81.7-1.71.81.81.81.71.71.61.71.21.5-0.90.6
Progressive ratio test 1 inactive lever presses1.52.13.92.01.91.71.3-1.31.61.6-1.61.61.61.61.31.2-1.21.51.51.51.31.31.31.31.01.5-1.10.8
Progressive ratio test 2 active lever presses2.73.15.22.32.12.01.8-1.81.91.9-1.91.91.91.91.71.8-1.81.81.91.81.81.71.71.71.41.9-0.2-0.1
Progressive ratio test 2 breakpoint3.03.55.52.32.22.11.9-1.82.02.0-2.02.02.02.01.81.9-1.91.91.91.91.91.81.81.81.52.0-0.30.0
Progressive ratio test 2 inactive lever presses0.40.62.41.51.41.00.5-0.51.00.9-0.90.90.90.90.40.6-0.60.70.70.70.60.50.50.5-0.01.00.0-0.4
Incentive Sensitization - Responses1.31.92.81.71.61.51.4-1.41.51.5-1.51.51.41.51.31.4-1.41.41.41.41.41.31.31.31.21.50.1-0.3
Incentive Sensitization - Breakpoint1.31.72.61.61.51.41.3-1.31.41.4-1.41.41.41.41.21.4-1.41.31.41.31.41.31.21.31.21.50.3-0.5
Sum of active levers in priming session hrs 5-60.30.30.9-0.9-0.9-0.7-0.30.3-0.6-0.60.6-0.6-0.6-0.6-0.3-0.20.2-0.5-0.2-0.5-0.3-0.4-0.4-0.5-0.1-0.80.1-0.0
Progressive ratio1.01.62.1-1.5-1.4-1.3-1.21.3-1.3-1.31.3-1.3-1.3-1.3-1.3-1.21.2-1.3-1.1-1.2-1.2-1.2-1.2-1.1-1.1-1.41.4-1.2
Food seeking constrained by brief footshock5.06.17.9-2.1-2.5-2.5-2.82.7-2.5-2.52.5-2.5-2.5-2.5-2.7-2.62.6-2.6-2.7-2.6-2.7-2.7-2.5-2.6-2.5-1.81.8-1.6
Seeking ratio, punishment vs. effort0.50.71.3-0.3-0.5-0.7-1.11.0-0.8-0.80.7-0.8-0.8-0.8-1.0-0.90.9-0.9-1.1-0.9-1.0-1.1-0.9-1.1-1.0-0.2-0.1-0.0
Retroperitoneal fat weight0.00.20.40.30.50.30.4-0.50.40.4-0.40.40.40.40.50.5-0.50.40.50.40.50.40.40.40.3-0.4-0.50.6
Reaction time number correct3.46.69.32.12.12.52.9-2.92.52.5-2.52.52.52.52.92.5-2.52.62.72.62.42.82.72.73.01.4-2.52.6
Reaction time mean minus median0.20.51.6-1.2-1.3-0.9-0.50.4-0.8-0.80.8-0.8-0.8-0.7-0.3-0.60.6-0.6-0.4-0.6-0.6-0.5-0.4-0.50.0-0.80.4-0.1
Reaction time mean minus median AUC0.00.10.5-0.4-0.5-0.10.3-0.4-0.1-0.10.0-0.0-0.00.00.40.1-0.10.10.40.10.20.30.30.20.7-0.3-0.40.6
Reaction time num false alarms4.76.68.32.72.92.72.7-2.62.72.7-2.72.72.72.62.62.7-2.72.62.62.62.62.62.42.42.21.9-2.42.2
Reaction time num false alarms AUC3.85.97.52.62.72.62.5-2.52.52.5-2.52.52.52.52.42.5-2.52.42.52.42.42.42.32.32.11.7-2.42.1
Reaction time trials correct on left3.46.69.32.12.12.52.9-2.92.52.5-2.52.52.52.52.92.5-2.52.62.72.62.42.82.72.73.01.4-2.52.6
Reaction time trials on left3.56.69.12.12.12.52.9-2.92.52.5-2.52.52.52.52.92.5-2.52.62.72.62.52.82.72.73.01.5-2.62.7
Reaction time mean1.32.12.8-1.7-1.7-1.6-1.51.4-1.6-1.61.6-1.6-1.6-1.6-1.4-1.31.3-1.5-1.3-1.5-1.3-1.5-1.4-1.5-1.3-1.30.8-0.6
Reaction time mean AUC1.01.62.3-1.5-1.5-1.4-1.31.2-1.4-1.41.4-1.4-1.4-1.4-1.2-1.21.2-1.3-1.1-1.3-1.2-1.3-1.2-1.3-1.1-1.00.7-0.5
Median of all reaction times1.52.12.6-1.5-1.5-1.6-1.61.5-1.6-1.61.6-1.6-1.6-1.6-1.5-1.31.3-1.6-1.4-1.6-1.4-1.6-1.5-1.6-1.6-1.20.7-0.7
Reaction time omissions0.10.11.00.40.40.1-0.0-0.00.10.1-0.10.10.10.10.00.2-0.20.00.20.00.3-0.1-0.1-0.1-0.20.2-1.01.0
Reaction time false alarm rate0.30.41.11.01.10.70.5-0.40.70.7-0.70.70.70.60.40.7-0.70.50.60.60.60.40.40.50.10.6-0.50.3
Reaction time premature initiation rate0.60.82.9-0.7-0.4-0.7-0.80.8-0.7-0.70.7-0.7-0.7-0.7-0.9-1.11.1-0.8-0.9-0.8-1.1-0.8-0.8-0.8-0.9-0.21.6-1.7
Reaction time premature initiations0.10.30.60.20.50.50.7-0.70.50.5-0.50.50.50.50.60.1-0.10.60.40.60.10.70.60.60.80.30.1-0.1
Std. dev. reaction times0.30.61.4-1.2-1.2-1.0-0.60.5-0.9-0.90.9-0.9-0.8-0.9-0.5-0.70.7-0.8-0.5-0.7-0.6-0.6-0.6-0.7-0.3-0.80.4-0.2
Reaction time trials completed3.56.69.12.12.12.52.9-2.92.52.5-2.52.52.52.52.92.5-2.52.62.72.62.52.82.72.73.01.5-2.62.7
Reaction time trials AUC4.28.110.82.42.42.83.2-3.22.82.8-2.82.82.82.83.12.8-2.82.92.92.92.73.13.02.93.31.7-2.82.8
Run reversals in cocaine runway, females0.50.51.2-0.6-0.5-0.6-0.70.6-0.6-0.50.6-0.6-0.6-0.6-0.6-0.70.7-0.6-0.7-0.6-0.7-0.6-0.5-0.6-0.8-0.71.1-1.1
Run reversals in cocaine runway, males0.40.40.80.50.60.60.8-0.80.60.6-0.60.60.70.60.80.9-0.90.70.70.70.80.70.70.70.70.3-0.20.1
Latency to leave start box in cocaine runway0.10.10.7-0.3-0.5-0.1-0.10.0-0.1-0.10.1-0.1-0.1-0.1-0.0-0.40.40.0-0.1-0.0-0.60.00.10.20.3-0.3-0.70.9
Latency to leave start box in cocaine runway, F0.40.41.50.20.00.50.7-0.60.50.6-0.50.60.60.60.60.1-0.10.70.50.7-0.10.70.70.91.00.3-1.11.2
Latency to leave start box in cocaine runway, M0.20.20.2-0.4-0.4-0.4-0.50.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.30.3-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.10.1
Std. dev. time between licks in bursts0.10.10.70.50.40.30.0-0.00.20.2-0.20.20.20.2-0.00.2-0.20.10.30.10.20.0-0.10.1-0.20.8-0.40.3
Total sessions with >9 infusions3.64.45.22.32.02.22.2-2.32.22.2-2.22.22.22.22.32.3-2.32.22.32.22.22.22.22.21.91.5-1.01.0
Short access day 1 total inactive lever presses1.11.43.61.91.71.40.9-0.91.31.3-1.31.21.21.20.91.2-1.21.11.01.11.30.80.80.70.11.0-1.61.3
Short access day 10 total inactive lever presses0.51.21.5-1.1-1.2-1.1-1.21.1-1.1-1.11.1-1.1-1.1-1.1-1.1-0.90.9-1.1-1.0-1.2-0.8-1.2-1.2-1.2-1.2-1.1-0.40.4
Short access day 1 total infusions2.12.83.51.81.51.71.7-1.71.71.7-1.71.71.71.71.71.9-1.91.71.81.71.71.71.71.71.41.3-1.41.4
Short access day 10 total infusions3.64.65.92.42.32.32.3-2.32.32.3-2.32.32.32.32.32.3-2.32.22.22.22.22.22.12.11.81.5-0.80.6
Short access total infusions2.43.14.32.11.91.91.8-1.81.91.9-1.91.91.91.81.81.9-1.91.81.91.81.81.71.71.71.41.4-0.70.6
Short access day 1 locomotion3.64.46.12.52.42.22.1-2.12.22.2-2.22.22.22.22.12.5-2.52.12.12.12.42.02.02.01.61.8-1.21.0
Short access day 10 total locomotion0.00.00.2-0.1-0.5-0.1-0.0-0.0-0.1-0.10.1-0.1-0.1-0.10.00.0-0.0-0.0-0.1-0.00.0-0.00.0-0.0-0.0-0.40.2-0.0
Short access total locomotion0.70.81.41.20.91.00.9-1.01.01.0-1.01.01.01.01.01.1-1.11.00.91.01.10.90.90.90.50.3-0.00.0
One hour access (0.3 mA shock)0.10.10.20.50.30.30.2-0.20.30.3-0.30.30.30.30.20.3-0.30.20.30.20.20.10.10.1-0.00.2-0.20.1
Compulsive drug intake0.20.32.60.1-0.20.20.3-0.40.20.2-0.20.30.30.30.40.1-0.10.30.30.30.30.30.40.30.4-0.0-1.61.6
One hour access (shock baseline)1.01.52.31.51.51.31.2-1.31.31.3-1.31.31.31.31.21.5-1.51.21.31.31.41.21.11.10.91.20.0-0.1
Social response proportion0.70.81.50.90.60.91.0-1.00.90.9-0.90.90.90.91.00.9-0.90.90.80.90.90.91.00.91.01.2-0.20.1
Social responses0.70.91.10.90.91.01.0-1.11.01.0-1.01.01.01.01.11.0-1.01.00.91.01.01.01.01.01.00.9-0.70.7
Social time3.44.76.1-1.9-2.0-2.1-2.32.3-2.1-2.12.1-2.1-2.1-2.1-2.3-2.52.5-2.2-2.5-2.2-2.3-2.3-2.3-2.2-2.4-2.11.4-1.3
Soleus weight0.10.30.50.60.60.60.5-0.60.60.6-0.60.60.60.60.60.6-0.60.60.60.60.60.50.60.50.4-0.0-0.60.7
Bone: stiffness0.81.31.71.31.31.21.0-1.21.21.2-1.21.21.21.21.21.1-1.11.11.01.11.11.01.21.00.80.8-1.21.2
Tibialis anterior weight3.411.414.53.83.73.63.4-3.43.63.5-3.53.53.53.53.33.4-3.43.53.33.43.43.33.43.23.13.3-2.72.3
Time to tail flick, vehicle, before self-admin2.72.83.61.61.41.71.9-1.81.71.7-1.71.71.71.71.81.7-1.71.81.91.71.71.81.81.81.81.8-0.50.5
Time to tail flick, vehicle, after self-admin0.10.21.0-0.7-0.5-0.20.1-0.1-0.2-0.20.2-0.2-0.1-0.20.1-0.30.3-0.0-0.1-0.0-0.30.20.10.20.6-0.6-0.91.0
Time to tail flick, test, before self-admin0.30.30.4-0.4-0.5-0.6-0.60.6-0.6-0.60.6-0.6-0.6-0.6-0.6-0.20.2-0.6-0.2-0.6-0.2-0.6-0.6-0.6-0.6-0.6-0.00.1
Time to tail flick, test, after self-admin0.20.21.20.1-0.1-0.2-0.40.4-0.2-0.20.3-0.3-0.3-0.3-0.5-0.70.7-0.3-0.4-0.3-0.5-0.3-0.4-0.3-0.6-0.51.0-1.1
Delta time to tail flick, vehicle, before/after SA0.40.41.8-0.7-0.5-0.5-0.40.4-0.5-0.50.5-0.5-0.5-0.5-0.4-0.50.5-0.4-0.6-0.4-0.6-0.3-0.4-0.3-0.0-0.9-1.31.4
Delta time to tail flick, test, before/after SA0.60.71.00.90.91.00.9-0.90.91.0-0.90.90.90.90.90.5-0.50.90.70.90.60.90.80.90.70.80.2-0.4
Tibia length0.20.71.71.21.30.90.7-0.70.90.9-0.90.90.90.90.80.9-0.90.70.90.80.90.60.60.80.30.3-0.30.1
Ambulatory time before self-admin0.00.00.1-0.3-0.1-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.0-0.10.1-0.1-0.2-0.1-0.1-0.1-0.1-0.10.0-0.2-0.10.2
Ambulatory time after self-admin0.60.81.3-1.1-1.0-0.9-0.70.7-0.9-0.80.9-0.8-0.8-0.8-0.7-1.01.0-0.8-0.9-0.8-1.0-0.7-0.7-0.7-0.6-1.01.1-1.0
Bone: tissue strength0.80.81.1-0.6-0.8-0.8-1.11.0-0.9-0.90.9-0.9-0.9-0.9-1.0-0.90.9-0.9-0.9-0.9-0.9-1.0-1.0-1.0-1.0-0.8-0.10.2
Total heroin consumption0.00.00.50.10.20.1-0.00.00.10.0-0.10.00.00.0-0.00.3-0.3-0.00.0-0.00.2-0.1-0.1-0.1-0.20.2-0.70.6
Bone: trabecular number0.10.10.80.2-0.1-0.1-0.30.3-0.1-0.20.2-0.2-0.2-0.2-0.3-0.20.2-0.2-0.2-0.2-0.1-0.3-0.4-0.3-0.40.20.9-0.9
Bone: trabecular spacing0.10.10.5-0.2-0.10.10.3-0.30.10.1-0.10.10.10.10.30.1-0.10.20.10.20.00.30.40.20.5-0.3-0.70.7
Bone: trabecular thickness1.41.72.51.31.41.31.5-1.41.31.3-1.31.31.31.31.41.4-1.41.31.51.31.41.41.11.31.21.60.1-0.3
Bone: trabecular tissue density0.20.40.70.40.60.60.8-0.80.60.6-0.60.60.60.60.80.6-0.60.60.70.70.50.70.60.80.8-0.10.0-0.1
Water consumed over 24 hours0.20.30.7-0.9-0.7-0.6-0.40.5-0.6-0.60.6-0.6-0.6-0.6-0.5-0.50.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.3-0.80.3-0.2
Number of responses in last shaping day3.13.44.71.41.31.62.0-2.01.71.7-1.71.71.71.72.02.1-2.11.82.01.82.21.91.91.82.01.3-2.22.2