Hub : Genes

Mfn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Mfn1 0.51 0.23 5.9e-05 0.13 0.18 0.21 0.2 5.1e-04 4.3e-05 1.1e-05 1.5e-05
2 Brain mRNA stability Mfn1 0.03 0.03 5.4e-03 0.01 0.02 0 0.01 6.8e-02 1.1e-02 1.7e-01 5.4e-02
3 RMTg mRNA stability Mfn1 0.25 0.15 3.6e-04 0.13 0.11 0.06 0.09 2.9e-04 7.1e-04 8.0e-03 2.0e-03
4 IL gene expression Mfn1 0.15 0.09 1.7e-03 0.13 0.05 0.08 0.09 4.1e-04 2.1e-02 5.2e-03 3.9e-03
5 Brain gene expression Mfn1 0.25 0.1 0.0e+00 0.28 0.3 0.3 0.3 5.4e-26 2.6e-28 3.2e-28 1.0e-28
6 Adipose gene expression Mfn1 0.16 0.07 0.0e+00 0.17 0.17 0.15 0.17 4.6e-19 5.1e-19 2.6e-16 8.4e-19
7 Adipose mRNA stability Mfn1 0.06 0.04 5.8e-07 0.05 0.05 0.04 0.04 1.4e-06 6.3e-06 4.2e-05 1.1e-05
8 NAcc gene expression Mfn1 0.17 0.08 0.0e+00 0.19 0.21 0.22 0.21 4.6e-21 3.6e-24 1.3e-24 1.1e-23
9 PL mRNA stability Mfn1 0.04 0.03 7.5e-07 0.04 0.06 0.04 0.05 1.0e-05 5.1e-07 9.7e-06 3.9e-06
10 Liver gene expression Mfn1 0.34 0.14 0.0e+00 0.33 0.32 0.33 0.33 2.9e-37 1.3e-36 4.4e-38 3.5e-38
11 PL gene expression Mfn1 0.19 0.11 0.0e+00 0.12 0.16 0.16 0.15 3.1e-13 7.3e-17 4.0e-17 6.8e-16
12 BLA mRNA stability Mfn1 0.09 0.06 4.1e-05 0.09 0.06 0.05 0.05 2.7e-05 6.3e-04 1.3e-03 9.9e-04
13 OFC gene expression Mfn1 0.15 0.11 3.3e-03 0.08 0.09 0.1 0.09 5.1e-03 4.2e-03 2.7e-03 3.7e-03
14 BLA gene expression Mfn1 0.11 0.07 1.9e-05 0.07 0.07 0.06 0.08 1.2e-04 8.6e-05 3.3e-04 4.9e-05
15 RMTg gene expression Mfn1 0.16 0.12 4.2e-03 0.08 0.06 0.08 0.05 4.0e-03 1.0e-02 4.5e-03 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density3.35.56.82.42.3-2.52.6-2.52.62.62.12.3-2.51.9-2.52.5-2.31.4
Area under the delay curve1.31.42.01.01.3-1.21.2-1.21.11.11.41.2-1.21.2-1.21.2-1.30.8
BMI with tail0.72.33.11.31.4-1.41.5-1.51.51.51.71.7-1.51.7-1.51.5-1.81.5
BMI without tail1.32.73.31.21.8-1.61.7-1.71.81.81.61.8-1.61.8-1.61.4-1.81.2
Body weight0.00.10.5-0.7-0.00.1-0.1-0.00.10.10.50.20.10.10.2-0.1-0.30.3
Weight adjusted by age1.72.03.8-0.4-1.51.2-0.41.4-1.3-1.3-2.0-1.61.3-1.61.3-1.51.7-1.5
Bone surface0.10.20.30.00.2-0.50.5-0.40.50.50.20.3-0.5-0.4-0.50.5-0.4-0.4
Bone volume0.20.40.80.30.4-0.70.8-0.70.90.90.30.4-0.7-0.2-0.70.7-0.5-0.4
Breakpoint value in progressive ratio session3.84.28.83.01.8-1.81.6-1.81.81.82.02.0-1.82.4-1.82.0-1.92.7
Number of licking bursts1.61.94.01.51.4-1.20.1-1.21.31.31.51.5-0.91.9-1.11.5-1.42.0
Context. condit. distance diff. score3.84.66.72.02.2-2.32.6-2.52.32.32.02.1-2.61.5-2.22.4-1.90.8
Locomotion velocity, session 11.21.32.1-0.9-1.41.5-1.21.2-1.4-1.4-0.7-1.01.2-0.51.4-0.90.90.7
Locomotion distance, session 10.30.40.9-0.4-0.60.7-0.80.6-0.6-0.60.0-0.30.70.20.9-0.50.31.0
Locomotion velocity, session 22.12.54.0-0.7-1.71.9-1.91.9-1.7-1.7-1.1-1.42.0-0.42.0-1.71.41.1
Locomotion distance, session 20.81.11.8-0.6-1.21.2-1.31.3-1.2-1.2-0.7-1.01.3-0.31.3-1.20.90.3
Locomotion velocity, session 30.00.00.20.0-0.20.1-0.20.1-0.1-0.1-0.1-0.00.10.10.2-0.40.10.3
Locomotion distance, session 30.20.20.5-0.1-0.40.5-0.50.6-0.5-0.5-0.4-0.40.60.10.7-0.20.60.3
Stereotopy head waving bouts, day 30.10.10.20.5-0.30.30.00.2-0.3-0.3-0.4-0.30.1-0.00.1-0.30.20.2
Stereotopy head waving duration, day 30.70.91.91.40.8-0.91.0-0.90.90.90.80.9-1.01.0-1.00.4-0.91.0
Locomotion velocity, session 70.80.81.6-0.3-1.10.8-1.00.9-0.8-0.8-0.9-0.91.1-0.81.0-1.31.1-0.2
Locomotion distance, session 70.70.81.2-0.7-1.00.9-0.80.9-0.9-0.9-1.1-1.01.0-0.91.0-0.81.1-0.8
Stereotopy head waving bouts, day 71.61.83.41.21.4-1.21.1-1.21.21.21.51.5-1.11.9-1.00.9-1.31.7
Stereotopy head waving duration, day 71.62.03.61.41.4-1.31.2-1.31.31.31.71.6-1.21.8-1.11.0-1.41.9
Locomotion velocity, session 82.32.73.71.61.6-1.51.7-1.61.61.61.81.7-1.51.9-1.41.6-1.71.8
Locomotion distance, session 80.60.91.60.80.8-1.01.2-1.21.01.01.10.9-1.20.6-1.00.9-0.90.4
Degree of sensitization distance1.21.22.6-1.1-1.10.9-0.80.8-0.9-0.9-1.3-1.20.8-1.50.8-1.01.1-1.6
Degree of sensitization stereotypy2.12.34.01.31.7-1.51.3-1.41.51.51.81.7-1.32.0-1.21.2-1.51.7
Conditioned locomotion0.10.11.3-0.40.1-0.20.1-0.20.10.1-0.4-0.1-0.2-0.6-0.2-0.00.2-1.1
Cocaine response after cond. corrected0.10.21.2-0.7-0.00.10.1-0.0-0.1-0.1-0.4-0.3-0.0-0.40.0-0.20.2-1.1
Cocaine response after cond. not corrected0.60.71.8-1.3-0.60.7-0.40.5-0.6-0.6-0.8-0.80.5-1.00.6-0.90.7-1.4
Cocaine response before conditioning0.00.10.2-0.1-0.40.1-0.20.1-0.1-0.1-0.0-0.20.2-0.50.3-0.40.20.1
Saline control response0.60.81.4-0.4-1.20.9-0.70.8-0.9-0.9-1.0-1.00.7-1.20.9-0.51.1-0.7
Bone: connectivity density2.03.23.82.01.7-1.81.8-1.81.81.81.61.8-1.81.6-1.81.9-1.81.5
Bone: cortical apparent density0.10.10.60.70.1-0.10.4-0.30.20.2-0.20.1-0.20.3-0.20.5-0.00.1
Bone: cortical area0.10.21.10.3-0.3-0.10.3-0.20.20.2-0.5-0.3-0.3-0.8-0.30.20.2-1.0
Bone: cortical porosity0.10.10.40.70.1-0.10.2-0.20.30.3-0.10.1-0.20.3-0.20.20.00.0
Bone: cortical porosity0.10.10.50.70.0-0.20.3-0.20.30.3-0.00.0-0.30.1-0.30.4-0.0-0.1
Bone: cortical thickness0.20.30.80.50.2-0.50.9-0.60.60.6-0.00.1-0.7-0.3-0.60.6-0.1-0.9
Bone: cortical thickness0.20.21.10.0-0.40.6-0.40.4-0.4-0.40.1-0.20.40.20.5-0.20.11.1
Bone: cortical tissue density0.10.10.60.80.1-0.20.4-0.30.20.2-0.20.1-0.30.3-0.20.5-0.00.2
Condit. Reinf. active minus inactive responses1.72.02.8-1.3-1.61.5-1.71.5-1.4-1.4-1.3-1.41.5-1.31.5-1.21.4-0.7
Condit. Reinf. active-inactive response ratio1.81.92.6-1.6-1.41.3-1.31.3-1.3-1.3-1.4-1.41.3-1.51.4-1.21.4-1.4
Condit. Reinf. active responses0.81.02.1-0.1-1.31.1-1.51.2-1.0-1.0-0.7-1.01.3-0.71.1-1.00.90.4
Condit. Reinf. inactive responses0.40.53.41.6-0.0-0.3-0.2-0.10.30.30.70.4-0.10.7-0.30.2-0.51.8
Incentive salience index mean1.92.33.2-1.5-1.71.7-1.81.7-1.5-1.5-1.2-1.61.6-1.51.5-1.51.4-0.8
Condit. Reinf. lever presses0.50.71.2-0.7-1.11.0-1.01.0-0.9-0.9-0.3-0.80.9-0.70.7-1.10.50.1
Condit. Reinf. active minus inactive responses1.51.93.6-0.9-1.51.2-1.71.3-1.2-1.2-1.3-1.41.4-1.31.5-1.91.5-0.8
Condit. Reinf. active-inactive response ratio1.61.63.0-1.3-1.21.2-1.31.1-1.1-1.1-1.4-1.31.1-1.31.3-1.71.4-1.3
Condit. Reinf. active responses2.84.06.0-1.4-2.32.0-2.52.1-1.9-1.9-1.8-2.02.3-1.82.2-2.32.1-0.6
Condit. Reinf. inactive responses1.41.72.7-0.6-1.61.4-1.71.6-1.4-1.4-1.0-1.21.6-0.81.5-1.21.20.5
Condit. Reinf. lever presses0.40.51.3-0.7-0.70.5-1.00.6-0.4-0.4-0.6-0.60.8-0.80.7-1.20.8-0.5
Condit. Reinf. lever reinforcers received2.73.75.8-1.3-2.21.9-2.42.0-1.9-1.9-1.7-2.02.2-1.72.1-2.32.0-0.6
Conditioned reinforcement - actives0.40.41.30.4-0.70.8-1.20.6-0.8-0.8-0.6-0.70.6-0.20.6-0.40.70.2
Conditioned reinforcement - inactives0.10.10.30.4-0.10.2-0.30.1-0.2-0.20.1-0.10.10.40.1-0.00.00.6
Conditioned locomotion0.40.51.61.0-0.80.8-0.70.7-0.8-0.8-0.3-0.50.70.40.7-0.20.51.3
Patch foraging indifference point 0 sec1.21.93.51.91.5-1.40.9-1.11.51.51.31.4-1.01.6-1.31.2-1.31.5
Patch foraging indifference point AUC1.51.74.90.51.3-1.11.0-1.10.90.91.91.6-1.01.8-0.80.9-1.42.2
Delay disc. indifference point, 0s delay0.20.20.5-0.4-0.70.5-0.60.6-0.6-0.6-0.3-0.50.5-0.40.5-0.40.40.1
Delay disc. indifference point, 16s delay1.91.94.72.21.3-1.41.4-1.31.31.31.21.2-1.41.4-1.31.4-1.20.9
Delay disc. indifference point, 2s delay0.60.71.00.30.9-0.90.9-0.90.80.81.00.9-0.90.7-0.90.9-0.90.4
Delay disc. indifference point, 24s delay1.51.43.21.81.3-1.21.4-1.31.21.20.81.1-1.31.0-1.21.2-1.00.3
Delay disc. indifference point, 4s delay0.40.41.10.60.5-0.40.5-0.50.40.40.90.6-0.50.7-0.50.6-0.61.0
Delay disc. indifference point, 8s delay0.20.20.50.10.7-0.50.4-0.50.50.50.70.6-0.40.6-0.40.4-0.60.3
Indifference point function ln k1.52.05.6-1.3-1.21.2-1.11.2-1.0-1.0-1.8-1.61.2-2.00.9-1.21.5-2.4
Indifference point function log k1.52.05.6-1.3-1.21.2-1.11.2-1.0-1.0-1.8-1.61.2-2.00.9-1.21.5-2.4
Patch foraging total patch changes 0 sec1.22.03.11.81.6-1.50.9-1.21.51.51.41.5-1.01.7-1.31.3-1.41.5
Patch foraging total patch changes 12 sec1.62.14.01.61.6-1.40.9-1.21.41.41.61.6-1.02.0-1.20.9-1.41.8
Patch foraging total patch changes 18 sec1.41.83.91.21.5-1.30.9-1.01.11.11.61.6-0.91.8-1.01.1-1.42.0
Patch foraging total patch changes 24 sec5.56.88.32.72.6-2.62.3-2.52.52.52.92.8-2.42.9-2.52.1-2.72.9
Patch foraging total patch changes 6 sec4.97.310.13.02.9-2.82.2-2.52.62.63.02.9-2.23.2-2.52.3-2.73.0
Patch foraging time to switch 0 sec0.10.10.50.1-0.30.20.00.2-0.3-0.3-0.5-0.40.0-0.50.1-0.10.4-0.7
Patch foraging water rate 0 sec0.40.61.00.40.9-0.90.4-0.70.90.90.90.9-0.50.8-0.80.4-1.00.5
Patch foraging water rate 12 sec0.00.10.60.8-0.10.0-0.10.10.10.1-0.4-0.20.2-0.1-0.2-0.20.1-0.2
Patch foraging water rate 18 sec0.20.20.5-0.0-0.50.5-0.70.6-0.4-0.4-0.4-0.40.7-0.10.4-0.70.20.3
Patch foraging water rate 24 sec1.52.14.32.11.3-1.41.1-1.31.61.61.51.4-1.11.5-1.41.1-1.51.7
Patch foraging water rate 6 sec0.00.00.10.40.1-0.10.0-0.00.20.20.20.10.10.3-0.3-0.1-0.40.3
Seeking ratio, delayed vs. immediate footshock0.81.04.52.10.6-0.80.9-1.10.80.80.20.6-1.30.6-1.11.2-0.50.2
Distance traveled before self-admin2.12.23.31.31.5-1.41.8-1.61.71.71.61.5-1.51.5-1.41.4-1.41.0
Distance traveled after self-admin0.70.72.11.00.8-0.71.2-0.60.80.80.90.8-0.41.2-0.40.4-0.61.5
Extensor digitorum longus weight0.10.62.70.70.3-0.30.4-0.50.60.61.20.7-0.41.0-0.30.5-0.91.6
Bone: elastic displacement0.10.10.60.1-0.00.00.1-0.00.00.0-0.7-0.3-0.1-0.3-0.1-0.70.3-0.8
Bone: elastic work0.91.23.1-0.5-1.20.8-0.60.8-0.7-0.7-1.7-1.30.7-1.50.7-1.31.3-1.8
Bone: endosteal estimation0.51.12.3-0.8-1.30.9-1.11.1-0.9-0.9-1.0-1.11.0-1.50.9-1.11.0-0.7
Bone: endosteal perimeter0.61.31.7-1.3-1.21.1-1.21.2-1.0-1.0-1.0-1.11.2-1.31.1-1.31.0-0.8
Epididymis fat weight0.81.83.9-2.0-1.41.4-1.31.3-1.3-1.3-1.2-1.21.4-1.51.3-1.51.0-1.0
Delta time in closed arm before/after self-admin0.20.20.40.10.2-0.40.3-0.60.60.6-0.00.4-0.6-0.1-0.60.5-0.5-0.4
Delta time in open arm before/after self-admin0.40.40.9-0.9-0.30.5-0.30.8-0.9-0.9-0.3-0.50.7-0.30.7-0.70.6-0.2
Diff in mean of infusions in LGA sessions0.30.41.40.70.4-0.61.2-0.60.60.60.30.4-0.70.2-0.70.5-0.5-0.2
Delay discount exponential model param1.61.62.1-1.1-1.41.3-1.31.3-1.2-1.2-1.5-1.41.3-1.31.3-1.31.4-0.8
Extinction: sum of active levers before priming0.20.20.60.5-0.50.30.10.4-0.2-0.2-0.4-0.50.5-0.40.6-0.50.80.0
Active lever presses in extinction session 60.20.21.21.10.2-0.3-0.4-0.30.30.3-0.00.2-0.20.5-0.40.3-0.20.5
Bone: final force0.30.51.6-0.0-1.10.6-0.50.5-0.4-0.4-0.9-0.80.5-1.30.4-0.40.7-0.8
Bone: final moment0.20.31.30.2-0.80.3-0.20.3-0.2-0.2-0.8-0.70.3-1.10.2-0.20.6-0.8
Food consumed during 24 hour testing period0.00.00.2-0.4-0.10.1-0.30.0-0.0-0.0-0.1-0.10.0-0.30.1-0.30.0-0.5
Glucose1.92.93.6-1.9-1.51.7-1.91.8-1.5-1.5-1.9-1.71.8-1.61.7-1.61.7-1.5
Heart weight0.50.72.71.70.5-0.80.8-0.80.80.80.70.7-1.00.8-0.80.7-0.70.8
Delay discount hyperbolic model param1.11.21.7-0.9-1.21.1-1.11.1-1.0-1.0-1.3-1.11.1-1.11.1-1.11.2-0.7
Intermittent access intake day 1-15 change0.70.72.20.90.9-0.70.1-0.70.70.70.80.9-0.51.5-0.40.6-0.71.3
Intermittent access intake escalation0.50.51.60.40.8-0.60.3-0.50.60.60.70.8-0.41.3-0.50.5-0.81.0
Intermittent access intake escalation 20.10.10.4-0.4-0.20.2-0.40.5-0.2-0.2-0.3-0.20.60.10.5-0.60.30.1
Intermitt. access day 1 inactive lever presses0.10.10.30.2-0.40.3-0.60.2-0.3-0.3-0.3-0.30.2-0.2-0.1-0.2-0.0-0.1
Intermitt. access day 15 inactive lever presses0.40.50.9-0.5-0.60.9-0.50.9-0.9-0.9-0.3-0.60.90.10.7-0.70.50.4
Intermitt. access escalation Index0.10.10.3-0.5-0.10.2-0.10.0-0.2-0.2-0.1-0.2-0.0-0.5-0.10.1-0.1-0.4
Intermittent access day 1 total infusions3.23.84.9-1.4-2.12.2-2.22.2-2.2-2.2-1.8-2.12.0-1.52.0-1.92.0-0.7
Intermittent access day 15 total infusions0.40.41.20.0-0.50.8-0.90.7-0.8-0.8-0.2-0.30.70.50.7-0.40.31.1
Intermittent access terminal intake (last 3 days)1.81.93.6-0.6-1.51.7-1.91.6-1.7-1.7-1.1-1.31.6-0.31.6-1.41.30.5
Intermittent access total infusions1.51.73.0-0.5-1.41.6-1.71.5-1.6-1.6-1.0-1.21.4-0.21.5-1.11.10.6
Intermittent access day 1 locomotion0.70.71.20.2-1.11.0-1.00.9-1.0-1.0-0.8-0.90.9-0.50.9-0.60.90.3
Intermittent access day 15 total locomotion1.81.96.62.60.9-0.90.8-1.00.90.91.31.1-0.92.1-0.91.3-1.12.5
Intermittent access total locomotion0.40.53.61.2-0.20.3-0.40.2-0.3-0.30.10.10.31.10.30.1-0.11.9
Intermittent access standard deviation0.10.10.40.20.5-0.40.3-0.30.40.40.50.4-0.20.6-0.30.2-0.40.4
Left kidney weight0.10.30.4-0.00.4-0.60.5-0.60.60.60.70.5-0.60.1-0.60.6-0.5-0.3
Right kidney weight0.41.01.70.81.0-1.00.8-1.01.11.11.31.1-0.91.2-0.71.0-1.01.1
Cocaine induced anxiety0.30.41.5-0.2-0.60.7-1.20.7-0.7-0.7-0.3-0.50.9-0.10.7-0.60.40.5
Post-drug Anxiety1.31.42.9-0.9-1.21.4-1.71.4-1.4-1.4-1.0-1.11.4-0.61.2-1.30.9-0.1
Baseline Anxiety0.30.31.20.40.7-0.61.1-0.40.60.60.50.5-0.50.5-0.60.2-0.4-0.1
Tail length0.00.10.5-0.60.2-0.2-0.1-0.00.20.2-0.1-0.00.1-0.40.0-0.50.1-0.7
Length with tail0.31.23.9-2.0-0.90.9-1.11.0-0.7-0.7-0.6-0.91.0-1.51.0-1.20.9-1.3
Length without tail1.22.64.9-1.7-1.81.5-1.51.6-1.5-1.5-1.3-1.71.5-2.21.6-1.31.7-1.7
Times rat made contact with spout1.21.42.2-1.3-1.01.2-1.41.2-1.2-1.2-1.2-1.21.2-1.01.1-1.51.1-0.9
Lifetime Intake2.12.43.6-0.9-1.71.9-1.91.7-1.9-1.9-1.4-1.51.7-0.71.7-1.41.40.1
Liver weight, left1.21.93.1-1.6-1.31.7-1.41.6-1.8-1.8-1.0-1.21.5-0.61.7-1.41.2-0.0
Liver weight, right0.10.10.20.0-0.30.4-0.30.3-0.5-0.5-0.4-0.30.2-0.10.2-0.30.3-0.1
Locomotor activity2.43.85.8-1.7-2.31.9-1.31.7-2.1-2.1-2.4-2.11.4-2.41.8-1.22.1-2.2
Locomotor testing distance0.91.42.8-0.3-1.71.2-0.91.1-1.3-1.3-1.6-1.41.0-1.21.2-0.91.4-0.7
Locomotor testing rearing0.10.20.60.8-0.70.3-0.20.3-0.3-0.3-0.7-0.60.2-0.50.3-0.30.6-0.4
Locomotion in novel chamber0.30.31.1-0.1-0.40.5-1.00.6-0.7-0.7-0.2-0.20.70.30.6-0.50.40.9
Locomotion in novel chamber post-restriction0.10.20.3-0.40.3-0.40.2-0.50.40.40.40.4-0.5-0.1-0.50.4-0.5-0.5
Fecal boli incidents, locomotor time 11.41.61.8-1.3-1.21.3-1.31.3-1.3-1.3-1.2-1.31.3-1.21.2-1.31.3-1.1
Change in fecal boli incidents, locomotor task0.70.72.51.60.7-0.70.7-0.60.80.80.40.8-0.71.0-0.50.8-0.61.1
Time >=10cm from walls, locomotor time 10.10.10.2-0.1-0.20.2-0.10.1-0.2-0.2-0.2-0.30.1-0.40.1-0.20.2-0.5
Bouts of movement, locomotor time 10.10.11.0-0.3-0.40.10.10.0-0.3-0.3-0.2-0.4-0.0-0.8-0.2-0.10.1-1.0
Total resting periods, locomotor time 10.20.21.6-0.6-0.30.2-0.20.2-0.3-0.3-0.4-0.50.1-0.80.0-0.30.3-1.2
Rest time, locomotor task time 10.91.01.4-0.7-1.11.1-1.01.1-1.1-1.1-1.2-1.11.0-0.81.0-1.01.2-0.6
Distance moved, locomotor task time 11.11.22.60.11.1-1.00.9-1.11.11.11.61.3-1.01.1-1.10.9-1.61.1
Vertical activity count, locomotor time 11.11.12.6-0.31.2-1.00.8-1.11.01.01.61.3-0.91.0-1.00.8-1.40.7
Time >=10cm from walls, locomotor time 20.30.30.5-0.7-0.50.6-0.60.6-0.6-0.6-0.7-0.60.7-0.50.5-0.60.4-0.5
Bouts of movement, locomotor time 20.10.20.40.30.4-0.40.6-0.40.20.20.10.2-0.4-0.1-0.60.4-0.3-0.7
Total resting periods, locomotor time 20.10.10.50.20.3-0.30.5-0.20.00.00.00.0-0.3-0.2-0.40.3-0.1-0.7
Rest time, locomotor task time 20.10.21.71.30.1-0.20.2-0.20.30.3-0.3-0.1-0.10.2-0.10.20.30.0
Distance moved, locomotor task time 20.20.32.4-1.5-0.10.2-0.10.1-0.4-0.40.60.2-0.0-0.0-0.1-0.0-0.70.5
Vertical activity count, locomotor time 20.70.83.5-1.9-0.70.9-1.01.0-1.1-1.1-0.3-0.51.0-0.30.9-0.80.20.4
Light reinforcement 10.40.72.2-0.2-1.00.7-0.60.6-0.7-0.7-1.2-1.10.6-1.10.5-0.41.0-1.5
Light reinforcement 20.10.10.2-0.5-0.30.3-0.20.2-0.3-0.3-0.1-0.20.2-0.20.3-0.10.2-0.4
Bone: marrow area0.40.81.8-0.7-1.20.8-0.91.0-0.8-0.8-0.8-0.90.9-1.40.8-1.00.8-0.5
Bone: maximum diameter0.00.10.4-0.1-0.3-0.0-0.10.10.10.1-0.2-0.20.0-0.6-0.0-0.20.1-0.5
Bone: maximum force0.50.92.5-0.4-1.20.8-0.60.8-0.6-0.6-1.3-1.10.7-1.60.6-0.71.1-1.3
Bone: maximum moment0.40.82.3-0.2-1.10.6-0.50.6-0.5-0.5-1.2-1.00.6-1.50.5-0.61.0-1.4
Mean time between licks in bursts1.21.74.6-1.7-1.21.1-0.01.0-1.0-1.0-1.3-1.41.0-1.71.1-1.11.4-2.1
Mean num. licks in bursts2.32.74.4-1.8-1.61.6-0.51.6-1.6-1.6-1.8-1.81.3-2.01.4-2.01.6-2.1
Cd content in liver1.21.31.9-0.9-1.21.3-0.21.4-1.3-1.3-1.1-1.21.3-0.81.3-1.41.1-0.5
Co content in liver0.30.40.8-0.9-0.60.8-0.50.7-0.7-0.7-0.1-0.40.80.00.9-0.70.30.3
Cu content in liver0.40.51.1-1.0-0.60.8-0.60.6-0.7-0.7-0.7-0.70.6-0.80.6-0.60.6-0.8
Fe content in liver0.50.61.1-0.4-0.60.7-0.90.8-0.9-0.9-1.1-0.80.7-0.60.5-0.90.7-0.6
K content in liver0.80.81.50.20.9-1.20.9-1.11.11.10.60.8-1.00.2-0.91.0-0.7-0.5
Mg content in liver0.40.42.1-0.40.4-0.70.4-0.70.70.70.10.3-0.7-0.5-0.60.4-0.1-1.4
Mn content in liver0.20.20.80.40.3-0.5-0.5-0.50.50.5-0.30.0-0.4-0.2-0.30.40.3-0.9
Na content in liver1.61.72.21.31.3-1.31.2-1.31.21.21.51.4-1.31.4-1.11.2-1.21.4
Rb content in liver0.40.51.81.30.6-0.90.7-0.70.40.4-0.00.6-0.90.6-0.90.9-0.50.1
Se content in liver0.81.01.8-0.9-1.01.1-1.31.1-1.2-1.2-0.9-1.01.1-0.81.1-0.90.9-0.2
Sr content in liver0.50.53.10.90.4-0.10.2-0.10.10.10.80.5-0.11.1-0.10.4-0.51.8
Zn content in liver0.20.21.4-0.90.2-0.20.00.10.20.2-0.0-0.10.1-0.4-0.1-0.50.1-1.2
Bone: minimum diameter0.91.74.4-1.1-1.51.0-0.91.1-0.9-0.9-1.4-1.51.0-2.10.9-0.91.3-2.0
Time in familiar zone, hab. session 10.10.10.8-0.9-0.20.5-0.10.3-0.4-0.40.1-0.10.2-0.10.30.0-0.10.2
Time in novel zone, hab. session 12.32.25.72.41.4-1.71.4-1.61.71.71.11.4-1.51.3-1.51.3-1.10.9
Total zone transitions, hab. session 10.50.61.10.70.7-0.90.3-0.80.90.91.10.9-0.61.0-0.50.5-0.81.0
Total locomotion distance, hab. session 12.53.64.82.21.7-2.01.8-2.02.12.12.01.9-1.91.8-1.81.6-1.81.7
Locomotion velocity, hab. session 12.13.04.02.01.6-1.91.6-1.81.91.91.81.8-1.81.7-1.61.5-1.61.5
Time in familiar zone, hab. session 20.10.10.3-0.5-0.20.20.10.1-0.2-0.2-0.1-0.20.0-0.5-0.00.10.0-0.6
Time in novel zone, hab. session 21.31.34.02.01.1-1.21.0-1.11.21.20.61.1-1.11.3-1.01.0-0.81.0
Total zone transitions, hab. session 20.10.10.60.4-0.10.1-0.40.2-0.1-0.10.1-0.00.30.50.3-0.30.10.7
Total locomotion distance, hab. session 20.20.20.70.70.3-0.40.3-0.40.40.40.50.5-0.40.6-0.30.2-0.40.8
Locomotion velocity, hab. session 20.10.10.60.50.1-0.20.0-0.10.10.10.30.2-0.10.40.00.1-0.20.7
Novel to familiar place preference ratio8.28.510.62.93.1-3.03.3-3.12.92.92.83.0-3.22.7-3.03.0-2.81.5
Novelty place preference10.510.713.23.33.5-3.43.6-3.53.43.43.13.3-3.63.1-3.33.3-3.11.7
Time in novel zone, NPP test11.511.814.73.53.6-3.63.8-3.73.53.53.33.5-3.83.2-3.53.6-3.31.8
Total zone transitions, NPP test0.91.32.3-0.9-1.31.3-1.51.3-1.3-1.3-0.5-1.01.4-0.41.5-0.91.00.6
Total locomotion distance, NPP test0.30.40.9-0.5-0.70.7-1.00.7-0.6-0.6-0.2-0.50.8-0.10.8-0.40.40.5
Locomotion velocity, NPP test0.50.71.5-0.7-1.00.9-1.21.0-0.9-0.9-0.5-0.81.1-0.51.1-0.80.70.3
Intraocular pressure0.81.11.8-0.4-1.31.3-0.81.0-1.3-1.3-1.3-1.20.8-0.90.9-0.91.0-0.7
Delta distance traveled before/after self-admin0.80.91.5-0.7-0.91.0-0.91.1-1.2-1.2-0.9-0.91.0-0.51.0-0.90.8-0.1
Delta ambulatory time before/after self-admin0.40.40.9-0.2-0.70.7-0.80.8-0.9-0.9-0.5-0.60.7-0.20.6-0.50.50.3
Parametrial fat weight0.00.10.2-0.4-0.50.3-0.30.3-0.3-0.30.1-0.20.3-0.30.3-0.30.00.3
Pavlov. Cond. lever latency1.51.93.41.91.4-1.61.7-1.51.41.40.81.3-1.61.0-1.41.8-1.00.4
Pavlov. Cond. magazine entry latency0.10.10.6-0.70.2-0.00.0-0.20.20.20.80.3-0.20.1-0.30.3-0.50.1
Pavlov. Cond. change in total contacts0.50.52.3-1.5-0.50.8-0.80.7-0.7-0.70.2-0.40.7-0.30.7-0.80.20.1
Pavlov. Cond. index score0.40.52.0-1.4-0.60.9-0.90.8-0.7-0.70.5-0.30.7-0.10.6-0.7-0.10.6
Pavlov. Cond. latency score0.91.13.4-1.8-1.01.3-1.41.2-1.1-1.1-0.1-0.81.2-0.51.0-1.20.40.1
Pavlov. Cond. lever contacts1.51.83.2-1.8-1.41.5-1.71.4-1.3-1.3-0.6-1.21.5-1.01.4-1.70.9-0.2
Pavlov. Cond. magazine entry number0.40.52.10.5-0.50.1-0.00.2-0.3-0.3-1.4-0.70.2-0.90.4-0.31.1-1.2
Pavlov. Cond. intertrial magazine entries0.30.40.8-0.4-0.40.3-0.80.6-0.5-0.5-0.8-0.60.7-0.50.7-0.80.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.31.5-1.2-0.40.7-0.70.5-0.5-0.50.6-0.20.50.10.4-0.5-0.20.7
Pavlov. Cond. response bias0.20.31.3-0.50.20.1-0.2-0.10.10.11.20.4-0.10.7-0.20.1-0.81.1
Pavlov. Cond. lever latency0.10.20.8-0.4-0.30.30.30.2-0.4-0.4-0.6-0.4-0.0-0.60.10.30.3-0.9
Pavlov. Cond. magazine entry latency0.10.10.3-0.50.4-0.1-0.1-0.00.10.10.40.30.10.50.0-0.2-0.30.0
Pavlov. Cond. change in total contacts0.70.92.3-0.8-0.91.0-1.31.1-0.9-0.9-0.6-0.81.2-0.41.2-1.50.90.2
Pavlov. Cond. index score0.10.10.6-0.10.2-0.1-0.30.00.10.10.50.30.20.60.1-0.3-0.30.8
Pavlov. Cond. latency score0.10.10.4-0.30.2-0.0-0.40.2-0.0-0.00.40.20.30.50.2-0.5-0.20.6
Pavlov. Cond. lever contacts0.40.50.90.90.8-0.80.1-0.50.80.80.80.8-0.30.9-0.60.2-0.71.0
Pavlov. Cond. magazine entry number0.30.41.1-0.2-0.70.5-0.30.5-0.4-0.4-1.0-0.70.4-1.10.4-0.20.7-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.7-0.0-0.70.3-0.30.4-0.3-0.3-0.3-0.40.3-0.80.2-0.20.30.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.20.20.0-0.40.2-0.0-0.00.40.20.30.60.2-0.5-0.20.8
Pavlov. Cond. response bias0.30.30.80.70.7-0.60.0-0.50.70.70.70.7-0.20.9-0.40.0-0.50.9
Time in closed arm before self-admin0.20.20.40.60.5-0.50.6-0.30.30.30.50.4-0.40.5-0.30.4-0.30.4
Time in closed arm after self-admin0.10.10.7-0.30.1-0.30.1-0.30.30.3-0.30.1-0.3-0.2-0.30.1-0.2-0.8
Time in open arm before self-admin1.01.01.71.00.8-0.70.9-1.21.01.00.71.0-1.30.9-1.31.3-1.20.5
Time in open arm after self-admin0.00.00.20.10.2-0.10.3-0.1-0.1-0.10.40.2-0.20.2-0.20.2-0.20.4
Bone: periosteal estimation0.30.62.4-0.5-1.10.6-0.50.6-0.5-0.5-0.9-0.90.5-1.60.5-0.70.8-1.1
Bone: periosteal perimeter0.30.51.4-0.5-0.80.5-0.50.5-0.4-0.4-0.8-0.70.5-1.20.4-0.70.7-1.0
Bone: post-yield work1.82.43.8-1.8-1.41.7-1.71.7-1.5-1.5-1.4-1.51.8-1.11.7-1.91.4-0.9
Progressive ratio test 1 active lever presses1.41.42.1-0.1-1.51.4-1.41.3-1.4-1.4-1.1-1.31.3-0.71.4-1.11.30.2
Progressive ratio test 1 breakpoint1.51.62.4-0.0-1.51.5-1.51.4-1.5-1.5-1.2-1.41.3-0.71.4-1.11.40.2
Progressive ratio test 1 inactive lever presses0.80.91.80.1-1.01.1-1.31.1-1.1-1.1-0.8-0.91.1-0.30.9-0.90.80.5
Progressive ratio test 2 active lever presses0.60.61.1-0.1-0.81.0-1.00.9-1.0-1.0-0.4-0.60.80.30.9-0.60.51.1
Progressive ratio test 2 breakpoint0.40.42.10.4-0.50.8-0.70.6-0.8-0.8-0.2-0.30.50.70.6-0.30.21.4
Progressive ratio test 2 inactive lever presses0.50.50.9-0.2-0.60.9-0.80.9-0.9-0.9-0.2-0.60.90.30.8-0.70.40.9
Incentive Sensitization - Responses0.30.32.00.50.10.10.1-0.0-0.1-0.10.40.4-0.11.1-0.00.2-0.51.4
Incentive Sensitization - Breakpoint0.20.22.00.4-0.00.3-0.10.1-0.3-0.30.30.20.01.00.10.1-0.41.4
Sum of active levers in priming session hrs 5-62.12.02.7-0.3-1.61.6-1.41.6-1.6-1.6-1.4-1.61.5-1.01.6-1.41.6-0.2
Progressive ratio0.10.10.20.1-0.50.3-0.40.3-0.4-0.4-0.4-0.40.3-0.30.3-0.20.4-0.1
Food seeking constrained by brief footshock0.20.20.70.50.3-0.5-0.1-0.60.40.40.40.3-0.7-0.1-0.90.7-0.6-0.3
Seeking ratio, punishment vs. effort0.60.71.10.40.9-0.80.8-0.90.90.91.00.9-0.90.6-1.00.8-1.00.2
Retroperitoneal fat weight0.20.71.4-0.6-1.20.9-0.70.8-0.8-0.8-0.9-0.90.8-1.10.8-0.80.8-0.6
Reaction time number correct2.43.45.4-1.2-2.12.3-2.12.1-2.3-2.3-1.9-1.82.0-0.91.9-1.71.60.0
Reaction time mean minus median0.10.10.9-0.90.10.20.00.1-0.2-0.2-0.1-0.10.1-0.10.40.10.2-0.6
Reaction time mean minus median AUC0.10.20.5-0.00.6-0.30.6-0.40.30.30.40.5-0.30.7-0.10.6-0.30.2
Reaction time num false alarms0.00.10.40.60.1-0.10.1-0.30.20.20.20.1-0.20.4-0.00.2-0.00.4
Reaction time num false alarms AUC0.00.00.30.4-0.10.1-0.1-0.10.00.00.10.00.00.40.20.10.10.5
Reaction time trials correct on left2.43.45.4-1.2-2.12.3-2.12.1-2.3-2.3-1.9-1.82.0-0.91.9-1.71.60.0
Reaction time trials on left2.53.65.6-1.3-2.12.4-2.12.1-2.3-2.3-2.0-1.92.0-1.02.0-1.71.7-0.1
Reaction time mean1.72.32.8-1.7-1.31.5-1.41.6-1.6-1.6-1.6-1.51.6-1.41.6-1.41.6-1.4
Reaction time mean AUC1.31.82.2-1.4-1.21.3-1.21.4-1.4-1.4-1.5-1.41.4-1.21.4-1.21.4-1.3
Median of all reaction times1.52.02.5-1.3-1.31.4-1.41.5-1.5-1.5-1.6-1.51.5-1.31.4-1.41.5-1.1
Reaction time omissions1.01.46.1-1.9-0.70.7-0.60.7-0.7-0.7-1.1-1.00.7-1.70.8-0.71.1-2.5
Reaction time false alarm rate0.81.21.61.21.1-1.21.1-1.21.31.31.11.0-1.11.0-0.91.0-0.80.6
Reaction time premature initiation rate0.60.81.50.31.1-1.10.9-1.01.21.21.01.0-0.90.5-1.00.7-0.9-0.0
Reaction time premature initiations0.10.10.2-0.4-0.20.4-0.40.3-0.2-0.2-0.2-0.20.3-0.10.2-0.30.1-0.0
Std. dev. reaction times0.20.31.2-1.1-0.20.5-0.20.4-0.4-0.4-0.3-0.40.5-0.40.6-0.30.5-0.8
Reaction time trials completed2.53.65.6-1.3-2.12.4-2.12.1-2.3-2.3-2.0-1.92.0-1.02.0-1.71.7-0.1
Reaction time trials AUC2.43.55.4-1.3-2.12.3-2.12.1-2.2-2.2-2.0-1.92.0-1.12.0-1.71.7-0.1
Run reversals in cocaine runway, females0.40.41.71.10.4-0.00.2-0.30.40.40.60.5-0.20.9-0.30.3-0.41.3
Run reversals in cocaine runway, males0.30.30.4-0.3-0.70.6-0.50.6-0.6-0.6-0.2-0.50.6-0.30.6-0.50.40.4
Latency to leave start box in cocaine runway0.20.20.6-0.7-0.20.4-0.70.3-0.3-0.3-0.5-0.30.3-0.50.3-0.40.3-0.7
Latency to leave start box in cocaine runway, F0.30.31.0-1.0-0.30.5-0.90.3-0.3-0.3-0.5-0.40.4-0.60.3-0.40.3-0.9
Latency to leave start box in cocaine runway, M0.00.00.10.10.1-0.10.2-0.10.10.1-0.10.0-0.1-0.0-0.10.00.0-0.2
Std. dev. time between licks in bursts0.70.82.9-1.7-0.70.6-0.30.7-0.5-0.5-0.4-0.80.9-1.20.7-1.00.7-1.3
Total sessions with >9 infusions1.71.93.2-0.8-1.51.4-1.81.2-1.4-1.4-1.7-1.51.2-1.41.1-1.01.4-1.4
Short access day 1 total inactive lever presses1.51.64.61.90.8-0.81.1-1.00.80.81.41.1-1.11.5-1.21.3-1.42.1
Short access day 10 total inactive lever presses1.51.72.70.81.3-1.21.3-1.31.21.21.41.4-1.31.3-1.51.2-1.61.0
Short access day 1 total infusions0.60.71.0-0.3-1.00.9-0.70.9-0.9-0.9-0.9-0.80.9-0.70.9-0.70.8-0.1
Short access day 10 total infusions1.51.63.3-0.6-1.41.5-1.81.4-1.5-1.5-1.3-1.31.4-0.71.3-1.21.3-0.3
Short access total infusions2.12.43.2-1.1-1.71.8-1.71.6-1.8-1.8-1.7-1.61.6-1.31.6-1.31.5-0.7
Short access day 1 locomotion0.60.72.01.40.5-0.50.4-0.70.50.50.60.7-0.71.1-0.60.9-0.71.4
Short access day 10 total locomotion0.70.71.21.00.7-0.80.5-0.80.80.81.00.9-0.71.1-0.80.9-1.01.1
Short access total locomotion0.30.30.80.4-0.70.7-0.90.5-0.7-0.7-0.7-0.60.5-0.10.4-0.20.40.2
One hour access (0.3 mA shock)0.60.71.5-0.5-0.81.0-1.21.0-1.0-1.0-0.6-0.71.10.11.1-0.80.70.4
Compulsive drug intake0.30.40.6-0.6-0.70.5-0.40.7-0.5-0.5-0.6-0.60.8-0.80.6-0.70.6-0.4
One hour access (shock baseline)0.91.12.2-0.9-0.91.3-1.51.2-1.3-1.3-0.9-0.91.2-0.11.2-1.00.90.1
Social response proportion3.23.44.9-1.7-1.71.7-1.81.9-1.7-1.7-2.1-1.92.0-1.91.8-2.21.9-1.7
Social responses0.10.21.01.00.3-0.40.0-0.10.30.30.20.3-0.00.6-0.1-0.0-0.20.6
Social time3.44.57.2-1.9-2.12.1-1.61.9-2.1-2.1-2.6-2.41.7-2.21.9-2.12.3-2.7
Soleus weight10.129.636.24.55.4-5.76.0-6.06.06.05.55.4-5.94.3-5.75.9-5.42.7
Bone: stiffness0.20.31.0-0.3-0.60.4-0.20.4-0.3-0.3-0.7-0.60.4-0.80.3-0.20.6-1.0
Tibialis anterior weight0.41.34.21.40.6-0.80.9-1.01.01.01.61.1-0.91.1-0.70.9-1.22.0
Time to tail flick, vehicle, before self-admin1.61.63.9-1.5-1.01.1-1.21.1-0.9-0.9-1.6-1.21.1-1.31.1-1.31.3-2.0
Time to tail flick, vehicle, after self-admin1.92.03.0-1.6-1.21.5-1.71.5-1.4-1.4-1.4-1.41.6-0.91.5-1.61.4-0.8
Time to tail flick, test, before self-admin1.81.74.31.11.4-1.52.1-1.41.51.50.91.2-1.50.7-1.31.2-1.0-0.3
Time to tail flick, test, after self-admin3.33.44.31.62.0-1.91.6-2.02.02.01.91.8-2.01.6-2.12.0-1.90.9
Delta time to tail flick, vehicle, before/after SA0.80.81.8-1.4-0.70.9-0.91.0-1.0-1.0-0.5-0.81.0-0.50.9-0.90.7-0.2
Delta time to tail flick, test, before/after SA1.71.62.80.81.3-1.10.5-1.31.11.11.71.4-1.11.4-1.31.4-1.51.4
Tibia length3.910.914.3-3.5-3.43.2-3.33.3-3.4-3.4-3.1-3.43.3-3.83.2-3.13.2-2.9
Ambulatory time before self-admin1.41.52.61.21.1-1.21.6-1.31.41.41.21.2-1.21.1-1.11.1-1.00.7
Ambulatory time after self-admin0.50.51.31.20.5-0.61.0-0.50.60.60.70.5-0.40.9-0.30.4-0.41.1
Bone: tissue strength0.90.85.8-0.5-0.70.1-0.00.2-0.2-0.2-1.2-0.90.1-1.70.1-0.20.9-2.4
Total heroin consumption6.47.513.73.72.4-2.52.3-2.82.62.62.72.6-2.72.8-2.82.9-2.72.5
Bone: trabecular number7.111.013.23.63.3-3.23.3-3.33.33.33.33.4-3.33.5-3.23.3-3.43.1
Bone: trabecular spacing4.76.07.1-2.6-2.42.4-2.22.3-2.2-2.2-2.6-2.62.4-2.72.4-2.42.7-2.6
Bone: trabecular thickness0.30.40.60.60.7-0.70.7-0.70.80.80.40.6-0.70.5-0.80.6-0.60.0
Bone: trabecular tissue density0.91.34.6-2.1-0.70.8-0.70.9-0.9-0.9-0.9-0.90.9-1.20.9-1.10.9-2.1
Water consumed over 24 hours0.00.00.40.1-0.10.0-0.60.1-0.0-0.0-0.2-0.10.1-0.3-0.0-0.20.1-0.1
Number of responses in last shaping day0.70.82.31.30.7-0.60.5-0.70.60.60.90.8-0.61.3-0.60.8-0.81.5