Hub : Genes

Meis3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative TSS	XM_039081690.2	0.03	0.03	5.8e-03	0.02	0.01	0	0.02	1.7e-03	8.0e-03	9.9e-02	6.1e-03
2	PL	alternative TSS	XM_039081690.2	0.13	0.15	3.0e-03	0.03	0.02	0	0.02	6.7e-04	1.7e-03	1.8e-01	1.6e-03
3	Brain	mRNA stability	Meis3	0.03	0.03	3.8e-03	0	0.01	0	0	1.5e-01	6.1e-02	1.4e-01	1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.1	0.3	0.1	0.1	-0.5
Area under the delay curve	1.1	1.2	1.8	1.3	1.3	-0.5
BMI with tail	1.1	3.9	4.7	-1.9	-1.9	2.2
BMI without tail	1.7	5.3	6.9	-2.1	-2.1	2.6
Body weight	2.0	8.8	9.4	-2.9	-2.9	3.1
Weight adjusted by age	0.2	0.3	0.5	-0.4	-0.4	0.7
Bone surface	0.3	0.6	0.8	-0.9	-0.9	0.3
Bone volume	0.1	0.1	0.2	-0.4	-0.4	-0.1
Breakpoint value in progressive ratio session	1.8	2.1	2.5	1.6	1.6	-1.2
Number of licking bursts	2.3	3.7	3.9	-2.0	-2.0	1.8
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion velocity, session 1	0.5	0.6	0.7	0.7	0.7	-0.8
Locomotion distance, session 1	0.1	0.1	0.2	0.1	0.1	-0.5
Locomotion velocity, session 2	1.7	2.0	2.3	-1.5	-1.5	1.1
Locomotion distance, session 2	0.5	0.6	0.8	-0.8	-0.8	0.9
Locomotion velocity, session 3	0.1	0.1	0.1	-0.3	-0.3	0.3
Locomotion distance, session 3	1.1	1.2	1.6	1.3	1.3	-0.7
Stereotopy head waving bouts, day 3	0.7	0.9	1.1	-1.0	-1.0	0.7
Stereotopy head waving duration, day 3	0.6	0.8	1.0	-1.0	-1.0	0.4
Locomotion velocity, session 7	1.3	1.4	1.7	1.1	1.1	-1.3
Locomotion distance, session 7	0.0	0.1	0.1	0.2	0.2	-0.2
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	-0.5	-0.5	0.6
Stereotopy head waving duration, day 7	0.4	0.4	0.4	-0.7	-0.7	0.6
Locomotion velocity, session 8	0.1	0.1	0.1	0.3	0.3	-0.4
Locomotion distance, session 8	0.0	0.0	0.1	-0.1	-0.1	0.2
Degree of sensitization distance	0.6	0.6	0.8	-0.9	-0.9	0.4
Degree of sensitization stereotypy	0.4	0.4	0.7	-0.5	-0.5	0.8
Conditioned locomotion	0.1	0.1	0.2	0.4	0.4	0.1
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.5	-0.5	0.5
Cocaine response after cond. not corrected	1.0	1.1	1.3	-1.1	-1.1	0.9
Cocaine response before conditioning	2.3	2.8	3.4	-1.9	-1.9	1.2
Saline control response	1.0	1.3	1.5	-1.2	-1.2	1.0
Bone: connectivity density	0.0	0.0	0.0	-0.2	-0.2	-0.2
Bone: cortical apparent density	0.2	0.2	0.3	0.5	0.5	-0.3
Bone: cortical area	1.6	2.5	3.2	-1.8	-1.8	1.0
Bone: cortical porosity	0.0	0.0	0.0	-0.2	-0.2	0.1
Bone: cortical porosity	0.2	0.2	0.3	-0.5	-0.5	0.5
Bone: cortical thickness	0.5	0.8	1.2	-1.1	-1.1	0.4
Bone: cortical thickness	0.5	0.6	0.7	-0.8	-0.8	0.6
Bone: cortical tissue density	0.2	0.3	0.4	0.6	0.6	-0.4
Condit. Reinf. active minus inactive responses	0.7	0.8	1.0	-0.8	-0.8	1.0
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.4	-0.9	-0.9	1.2
Condit. Reinf. active responses	0.2	0.3	0.5	-0.5	-0.5	0.7
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.7	0.7	-0.8
Incentive salience index mean	0.6	0.7	0.8	-0.8	-0.8	0.9
Condit. Reinf. lever presses	0.2	0.2	0.3	-0.4	-0.4	0.6
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	0.2	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.2	0.2	-0.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.3	0.3	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.4	0.4	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.3	-0.6	-0.6	0.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.3	0.3	-0.5
Conditioned reinforcement - actives	2.3	3.9	4.2	-2.0	-2.0	1.9
Conditioned reinforcement - inactives	1.7	2.5	3.4	-1.8	-1.8	0.9
Conditioned locomotion	1.8	2.3	2.7	-1.7	-1.7	1.2
Patch foraging indifference point 0 sec	0.1	0.3	0.4	-0.6	-0.6	0.2
Patch foraging indifference point AUC	3.3	4.8	5.4	-2.1	-2.1	2.3
Delay disc. indifference point, 0s delay	0.6	0.6	0.7	0.8	0.8	-0.7
Delay disc. indifference point, 16s delay	0.4	0.5	0.7	0.8	0.8	-0.2
Delay disc. indifference point, 2s delay	1.3	1.5	1.9	1.4	1.4	-0.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	-0.2	0.5
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.1	-0.1	0.4
Delay disc. indifference point, 8s delay	2.1	2.4	3.3	1.8	1.8	-0.9
Indifference point function ln k	1.8	3.1	5.0	1.5	1.5	-2.2
Indifference point function log k	1.8	3.1	5.0	1.5	1.5	-2.2
Patch foraging total patch changes 0 sec	0.2	0.4	0.6	-0.8	-0.8	0.3
Patch foraging total patch changes 12 sec	1.4	1.9	2.3	-1.3	-1.3	1.5
Patch foraging total patch changes 18 sec	1.4	2.2	2.3	-1.5	-1.5	1.4
Patch foraging total patch changes 24 sec	1.3	2.2	2.2	-1.5	-1.5	1.4
Patch foraging total patch changes 6 sec	1.7	2.7	2.8	-1.7	-1.7	1.5
Patch foraging time to switch 0 sec	1.2	2.4	2.9	1.7	1.7	-1.2
Patch foraging water rate 0 sec	1.7	3.7	4.5	-2.1	-2.1	1.4
Patch foraging water rate 12 sec	0.1	0.2	0.3	-0.5	-0.5	-0.4
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.6	-0.6	-0.3
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.0	0.0	-0.5
Patch foraging water rate 6 sec	1.1	1.6	1.7	-1.3	-1.3	1.1
Seeking ratio, delayed vs. immediate footshock	2.5	3.1	3.1	1.8	1.8	-1.8
Distance traveled before self-admin	0.0	0.0	0.0	-0.0	-0.0	-0.2
Distance traveled after self-admin	0.8	1.0	1.0	1.0	1.0	-1.0
Extensor digitorum longus weight	1.8	7.2	7.5	-2.7	-2.7	2.6
Bone: elastic displacement	1.0	1.1	1.6	1.0	1.0	-1.3
Bone: elastic work	0.0	0.1	0.1	-0.2	-0.2	-0.3
Bone: endosteal estimation	0.0	0.1	0.1	0.3	0.3	-0.2
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	-0.1	0.0
Epididymis fat weight	0.2	0.6	0.8	0.6	0.6	-0.9
Delta time in closed arm before/after self-admin	0.7	0.7	0.9	0.9	0.9	-0.5
Delta time in open arm before/after self-admin	0.4	0.4	0.5	-0.7	-0.7	0.4
Diff in mean of infusions in LGA sessions	2.1	2.6	3.3	1.8	1.8	-1.1
Delay discount exponential model param	0.9	0.9	1.4	-1.2	-1.2	0.3
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	-0.1	-0.2
Active lever presses in extinction session 6	1.0	1.0	2.0	-0.7	-0.7	1.4
Bone: final force	0.8	1.3	1.6	-1.3	-1.3	0.8
Bone: final moment	1.0	1.6	2.0	-1.4	-1.4	0.8
Food consumed during 24 hour testing period	3.5	4.8	4.9	2.2	2.2	-2.2
Glucose	1.6	2.5	2.8	1.7	1.7	-1.4
Heart weight	1.1	1.8	2.2	-1.5	-1.5	0.9
Delay discount hyperbolic model param	0.7	0.8	1.1	-1.1	-1.1	0.2
Intermittent access intake day 1-15 change	0.1	0.2	0.2	-0.4	-0.4	0.5
Intermittent access intake escalation	0.2	0.4	0.5	-0.6	-0.6	0.7
Intermittent access intake escalation 2	0.1	0.1	0.1	0.3	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.2	0.6	0.6	-0.8	-0.8	0.7
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.7	-0.7	-0.7	0.8
Intermitt. access escalation Index	0.1	0.2	0.3	0.5	0.5	0.2
Intermittent access day 1 total infusions	1.9	3.1	3.8	-1.9	-1.9	1.3
Intermittent access day 15 total infusions	0.9	1.3	1.5	-1.2	-1.2	1.0
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.2	-1.1	-1.1	0.7
Intermittent access total infusions	2.0	2.4	2.8	-1.7	-1.7	1.2
Intermittent access day 1 locomotion	0.7	0.9	1.3	-1.1	-1.1	0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.6	-0.6	-0.1
Intermittent access total locomotion	1.5	1.8	2.7	-1.6	-1.6	0.4
Intermittent access standard deviation	0.2	0.4	0.6	0.8	0.8	-0.2
Left kidney weight	5.4	24.9	28.1	-5.3	-5.3	4.3
Right kidney weight	4.5	20.6	23.2	-4.8	-4.8	3.9
Cocaine induced anxiety	0.1	0.2	0.4	0.2	0.2	-0.7
Post-drug Anxiety	0.1	0.2	0.3	0.3	0.3	-0.6
Baseline Anxiety	0.7	0.8	0.8	0.9	0.9	-0.9
Tail length	1.0	3.7	4.1	-1.9	-1.9	2.0
Length with tail	0.6	2.8	3.0	-1.7	-1.7	1.5
Length without tail	0.5	1.5	1.8	-1.3	-1.3	0.9
Times rat made contact with spout	0.2	0.3	0.4	0.4	0.4	-0.7
Lifetime Intake	2.4	2.9	3.3	-1.8	-1.8	1.4
Liver weight, left	3.7	6.2	7.5	-2.3	-2.3	2.7
Liver weight, right	1.6	2.8	3.4	-1.6	-1.6	1.9
Locomotor activity	2.0	3.1	3.2	-1.8	-1.8	1.8
Locomotor testing distance	1.8	3.2	3.5	-1.9	-1.9	1.7
Locomotor testing rearing	5.3	10.7	11.3	-3.4	-3.4	3.1
Locomotion in novel chamber	1.3	1.7	2.6	1.1	1.1	-1.6
Locomotion in novel chamber post-restriction	0.5	0.8	0.8	0.9	0.9	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.3	0.4	-0.7	-0.7	0.0
Change in fecal boli incidents, locomotor task	1.0	1.0	1.3	1.1	1.1	-0.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	-0.3	0.0
Bouts of movement, locomotor time 1	3.6	4.1	5.2	2.3	2.3	-1.4
Total resting periods, locomotor time 1	4.4	4.9	5.8	2.4	2.4	-1.8
Rest time, locomotor task time 1	0.5	0.6	0.8	0.7	0.7	-0.9
Distance moved, locomotor task time 1	0.9	1.4	1.4	-1.2	-1.2	1.2
Vertical activity count, locomotor time 1	0.2	0.5	0.5	-0.7	-0.7	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	0.2
Bouts of movement, locomotor time 2	4.1	6.5	8.1	2.8	2.8	-1.9
Total resting periods, locomotor time 2	3.8	6.7	7.9	2.8	2.8	-2.1
Rest time, locomotor task time 2	0.8	1.1	2.0	0.8	0.8	-1.4
Distance moved, locomotor task time 2	1.1	1.4	2.0	-1.0	-1.0	1.4
Vertical activity count, locomotor time 2	0.2	0.3	0.7	-0.3	-0.3	0.9
Light reinforcement 1	0.5	1.3	1.6	-1.3	-1.3	0.8
Light reinforcement 2	1.2	1.8	2.0	-1.4	-1.4	1.2
Bone: marrow area	0.0	0.0	0.1	0.2	0.2	-0.1
Bone: maximum diameter	2.7	5.1	5.5	-2.3	-2.3	2.1
Bone: maximum force	0.3	0.6	0.7	-0.9	-0.9	0.5
Bone: maximum moment	0.4	0.7	0.9	-1.0	-1.0	0.5
Mean time between licks in bursts	0.0	0.0	0.1	-0.1	-0.1	0.3
Mean num. licks in bursts	3.5	5.4	5.5	2.3	2.3	-2.3
Cd content in liver	0.4	0.4	0.8	0.5	0.5	-0.9
Co content in liver	0.9	1.0	1.0	1.0	1.0	-1.0
Cu content in liver	0.3	0.4	0.4	-0.6	-0.6	0.7
Fe content in liver	2.5	3.1	3.3	-1.7	-1.7	1.8
K content in liver	0.3	0.3	0.6	-0.3	-0.3	0.8
Mg content in liver	1.2	1.2	1.7	-1.0	-1.0	1.3
Mn content in liver	0.6	0.6	0.8	-0.7	-0.7	0.9
Na content in liver	0.0	0.0	0.0	0.0	0.0	0.2
Rb content in liver	0.1	0.1	0.1	-0.2	-0.2	0.2
Se content in liver	6.0	7.1	10.5	-2.3	-2.3	3.2
Sr content in liver	0.0	0.0	0.0	-0.2	-0.2	0.1
Zn content in liver	2.8	3.1	3.4	-1.7	-1.7	1.8
Bone: minimum diameter	0.1	0.2	0.2	-0.4	-0.4	0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.5	-0.5	-0.3
Time in novel zone, hab. session 1	0.8	0.8	1.6	-0.6	-0.6	1.3
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.0	0.0	-0.2
Total locomotion distance, hab. session 1	0.5	0.7	0.7	0.8	0.8	-0.8
Locomotion velocity, hab. session 1	1.2	1.7	1.7	1.3	1.3	-1.3
Time in familiar zone, hab. session 2	0.5	0.5	0.7	-0.9	-0.9	-0.1
Time in novel zone, hab. session 2	0.4	0.4	0.5	0.7	0.7	0.3
Total zone transitions, hab. session 2	0.4	0.6	0.8	-0.9	-0.9	0.3
Total locomotion distance, hab. session 2	0.5	0.7	0.8	0.8	0.8	-0.9
Locomotion velocity, hab. session 2	0.3	0.4	0.5	0.6	0.6	-0.7
Novel to familiar place preference ratio	0.5	0.5	0.7	-0.7	-0.7	0.8
Novelty place preference	0.4	0.4	0.5	-0.6	-0.6	0.7
Time in novel zone, NPP test	0.4	0.4	0.5	-0.6	-0.6	0.7
Total zone transitions, NPP test	0.2	0.3	0.3	-0.6	-0.6	0.4
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	-0.1	0.1
Intraocular pressure	0.1	0.2	0.3	0.4	0.4	-0.5
Delta distance traveled before/after self-admin	0.8	0.8	1.0	1.0	1.0	-0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.5	0.5	-0.4
Parametrial fat weight	0.0	0.0	0.1	0.1	0.1	-0.3
Pavlov. Cond. lever latency	0.8	1.0	1.2	1.0	1.0	-1.1
Pavlov. Cond. magazine entry latency	0.8	1.1	1.4	-0.9	-0.9	1.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	0.4	-0.1
Pavlov. Cond. index score	1.0	1.3	1.7	-1.0	-1.0	1.3
Pavlov. Cond. latency score	0.6	0.7	0.9	-0.8	-0.8	0.9
Pavlov. Cond. lever contacts	0.6	0.7	0.9	-0.8	-0.8	0.9
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	0.8	0.8	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.1	0.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	1.7	-1.1	-1.1	1.3
Pavlov. Cond. response bias	1.9	2.4	2.9	-1.5	-1.5	1.7
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.5	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	-0.3	0.2
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	0.6	0.6	-0.8
Pavlov. Cond. index score	0.0	0.1	0.1	-0.3	-0.3	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.1	-0.1
Pavlov. Cond. lever contacts	0.3	0.5	0.5	-0.7	-0.7	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.5	-0.5	0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.3	-0.3	0.2
Time in closed arm before self-admin	0.5	0.7	0.9	-0.9	-0.9	0.6
Time in closed arm after self-admin	1.4	1.5	2.0	1.4	1.4	-0.7
Time in open arm before self-admin	0.6	0.7	0.9	1.0	1.0	-0.4
Time in open arm after self-admin	0.0	0.0	0.0	-0.2	-0.2	-0.1
Bone: periosteal estimation	0.2	0.5	0.6	-0.8	-0.8	0.5
Bone: periosteal perimeter	0.5	0.9	1.2	-1.1	-1.1	0.5
Bone: post-yield work	0.2	0.4	0.4	0.6	0.6	-0.6
Progressive ratio test 1 active lever presses	2.3	2.9	3.7	-1.9	-1.9	1.1
Progressive ratio test 1 breakpoint	2.1	2.5	3.3	-1.8	-1.8	1.0
Progressive ratio test 1 inactive lever presses	1.9	2.7	3.1	-1.7	-1.7	1.4
Progressive ratio test 2 active lever presses	3.6	4.2	4.7	-2.2	-2.2	1.8
Progressive ratio test 2 breakpoint	3.9	4.5	5.1	-2.3	-2.3	1.8
Progressive ratio test 2 inactive lever presses	1.4	2.2	2.5	-1.6	-1.6	1.3
Incentive Sensitization - Responses	2.2	3.0	3.5	-1.9	-1.9	1.4
Incentive Sensitization - Breakpoint	2.4	3.1	3.5	-1.9	-1.9	1.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.6	0.8	0.8	-0.6
Progressive ratio	0.8	1.2	1.6	1.3	1.3	-0.6
Food seeking constrained by brief footshock	2.9	3.6	4.6	1.8	1.8	-2.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.7	0.3	0.3	-0.9
Retroperitoneal fat weight	0.0	0.0	0.0	0.1	0.1	-0.1
Reaction time number correct	2.5	4.8	5.8	-2.4	-2.4	1.7
Reaction time mean minus median	0.6	1.5	1.6	1.3	1.3	-1.1
Reaction time mean minus median AUC	0.1	0.2	0.2	0.4	0.4	-0.4
Reaction time num false alarms	5.1	7.1	7.7	-2.6	-2.6	2.8
Reaction time num false alarms AUC	3.8	6.0	6.4	-2.4	-2.4	2.5
Reaction time trials correct on left	2.5	4.8	5.8	-2.4	-2.4	1.7
Reaction time trials on left	2.6	5.0	6.0	-2.4	-2.4	1.7
Reaction time mean	1.9	3.0	3.3	1.8	1.8	-1.6
Reaction time mean AUC	1.4	2.2	2.4	1.5	1.5	-1.3
Median of all reaction times	1.7	2.4	2.7	1.7	1.7	-1.3
Reaction time omissions	0.1	0.2	0.3	-0.5	-0.5	0.2
Reaction time false alarm rate	0.5	0.6	1.2	-0.6	-0.6	1.1
Reaction time premature initiation rate	0.6	0.9	2.1	0.5	0.5	-1.5
Reaction time premature initiations	0.2	0.4	0.4	-0.7	-0.7	-0.6
Std. dev. reaction times	0.9	1.6	1.7	1.3	1.3	-1.2
Reaction time trials completed	2.6	5.0	6.0	-2.4	-2.4	1.7
Reaction time trials AUC	3.2	6.2	7.3	-2.7	-2.7	2.0
Run reversals in cocaine runway, females	0.6	0.6	1.5	0.3	0.3	-1.2
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.4	-0.4	0.7
Latency to leave start box in cocaine runway	0.4	0.4	0.5	0.6	0.6	-0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.0	0.0	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	0.4	-0.2
Std. dev. time between licks in bursts	0.2	0.3	0.7	-0.2	-0.2	0.8
Total sessions with >9 infusions	2.9	3.5	4.2	-2.1	-2.1	1.4
Short access day 1 total inactive lever presses	2.7	3.6	4.1	-2.0	-2.0	1.6
Short access day 10 total inactive lever presses	0.4	1.0	1.2	0.9	0.9	-1.1
Short access day 1 total infusions	1.7	2.3	2.6	-1.6	-1.6	1.3
Short access day 10 total infusions	4.2	5.3	5.6	-2.4	-2.4	2.2
Short access total infusions	2.5	3.1	3.4	-1.8	-1.8	1.6
Short access day 1 locomotion	3.4	4.2	4.8	-2.2	-2.2	1.7
Short access day 10 total locomotion	0.1	0.2	0.5	-0.0	-0.0	-0.7
Short access total locomotion	0.8	1.0	1.4	-1.2	-1.2	0.4
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	-0.3	0.2
Compulsive drug intake	0.1	0.1	0.1	-0.4	-0.4	0.2
One hour access (shock baseline)	0.6	0.9	1.0	-0.9	-0.9	1.0
Social response proportion	0.7	0.7	1.3	-0.7	-0.7	1.2
Social responses	1.3	1.7	2.3	-1.2	-1.2	1.5
Social time	2.1	2.8	3.8	2.0	2.0	-0.9
Soleus weight	0.6	1.6	1.8	-1.4	-1.4	1.1
Bone: stiffness	0.7	1.2	1.4	-1.1	-1.1	1.2
Tibialis anterior weight	4.1	14.0	14.8	-3.8	-3.8	3.6
Time to tail flick, vehicle, before self-admin	0.6	0.7	0.9	-1.0	-1.0	0.4
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.8	0.9	0.9	-0.5
Time to tail flick, test, before self-admin	1.7	1.7	2.2	1.2	1.2	-1.5
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.0	0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.6	0.6	-0.3
Delta time to tail flick, test, before/after SA	1.7	1.7	2.0	-1.4	-1.4	1.0
Tibia length	0.6	1.8	2.3	-1.2	-1.2	1.5
Ambulatory time before self-admin	0.1	0.1	0.1	0.2	0.2	-0.4
Ambulatory time after self-admin	1.0	1.2	1.3	1.1	1.1	-1.1
Bone: tissue strength	0.3	0.3	0.3	0.5	0.5	-0.5
Total heroin consumption	0.1	0.1	0.2	-0.3	-0.3	0.4
Bone: trabecular number	0.1	0.1	0.2	0.2	0.2	-0.4
Bone: trabecular spacing	0.0	0.0	0.0	-0.2	-0.2	0.2
Bone: trabecular thickness	0.4	0.5	0.6	-0.7	-0.7	0.8
Bone: trabecular tissue density	0.2	0.3	0.3	-0.5	-0.5	0.6
Water consumed over 24 hours	0.7	0.9	1.1	0.9	0.9	-1.1
Number of responses in last shaping day	2.4	2.6	2.8	-1.6	-1.6	1.7