Hub : Genes

Med31

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Med31 0.06 0.04 3.0e-04 0 0.01 0.01 0.01 8.3e-02 1.2e-02 1.6e-02 2.1e-02
2 BLA mRNA stability Med31 0.23 0.12 1.7e-09 0.16 0.16 0.17 0.16 3.7e-09 8.3e-09 3.1e-09 4.0e-09
3 Adipose gene expression Med31 0.1 0.06 1.9e-06 0.04 0.03 0.03 0.04 3.9e-05 1.3e-04 1.5e-04 9.0e-05
4 Brain gene expression Med31 0.23 0.11 0.0e+00 0.2 0.19 0.19 0.2 1.7e-18 2.9e-17 9.8e-18 4.5e-18
5 PL gene expression Med31 0.26 0.12 0.0e+00 0.22 0.22 0.21 0.22 4.7e-24 2.5e-23 1.8e-22 2.9e-23
6 NAcc gene expression Med31 0.19 0.1 2.2e-15 0.14 0.13 0.14 0.14 1.3e-15 5.4e-15 1.9e-15 1.8e-15
7 BLA gene expression Med31 0.38 0.15 1.1e-15 0.27 0.25 0.27 0.27 6.1e-15 1.1e-13 1.7e-14 7.2e-15
8 PL mRNA stability Med31 0.11 0.06 6.0e-10 0.08 0.08 0.08 0.08 1.9e-09 1.6e-09 3.8e-09 1.6e-09
9 NAcc mRNA stability Med31 0.14 0.08 1.8e-12 0.11 0.1 0.11 0.1 2.4e-12 4.5e-12 2.7e-12 3.6e-12
10 Brain mRNA stability Med31 0.07 0.04 1.7e-06 0.08 0.06 0.06 0.07 1.2e-07 1.3e-06 1.9e-06 4.3e-07
11 pVTA gene expression Med31 0.12 0.08 8.0e-05 0.11 0.05 0.1 0.02 1.7e-05 3.2e-03 3.5e-05 3.5e-02
12 pVTA mRNA stability Med31 0.06 0.04 7.7e-03 0.01 0.02 0.02 0 1.8e-01 6.0e-02 6.1e-02 1.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.41.9-0.0-0.1-0.4-0.5-0.5-0.5-0.5-0.70.70.70.6-1.4
Area under the delay curve0.00.00.1-0.00.1-0.00.30.30.30.30.1-0.1-0.1-0.30.4
BMI with tail0.30.81.3-0.90.90.80.80.80.70.7-1.20.91.01.1-0.9
BMI without tail0.40.91.6-0.90.80.60.80.80.70.7-1.31.01.11.0-1.2
Body weight0.41.57.3-0.30.1-0.6-0.4-0.4-0.5-0.5-1.71.51.61.5-2.7
Weight adjusted by age2.63.04.6-2.01.82.21.61.61.51.5-1.71.91.71.7-1.3
Bone surface0.71.32.4-1.21.10.70.80.80.80.8-1.51.51.41.3-1.5
Bone volume1.22.03.2-1.51.41.11.01.01.01.0-1.71.81.71.6-1.6
Breakpoint value in progressive ratio session0.30.31.2-0.30.00.2-0.1-0.1-0.2-0.2-0.80.60.80.7-1.1
Number of licking bursts0.20.20.50.4-0.4-0.1-0.3-0.3-0.3-0.30.6-0.6-0.6-0.70.6
Context. condit. distance diff. score0.81.01.9-1.00.90.70.60.60.60.6-1.31.41.31.1-1.4
Locomotion velocity, session 11.31.44.8-0.80.5-0.10.00.0-0.0-0.0-1.61.61.61.8-2.2
Locomotion distance, session 10.71.01.5-1.10.90.90.70.70.70.7-1.21.11.21.2-0.9
Locomotion velocity, session 20.50.61.10.7-0.8-0.9-1.0-1.0-1.1-1.10.0-0.30.00.2-0.5
Locomotion distance, session 20.20.20.9-0.2-0.0-0.1-0.4-0.4-0.3-0.3-0.60.50.60.7-0.9
Locomotion velocity, session 32.02.33.41.7-1.3-1.8-1.1-1.1-1.0-1.01.8-1.7-1.8-1.81.5
Locomotion distance, session 30.10.10.20.4-0.4-0.4-0.3-0.3-0.3-0.30.3-0.4-0.3-0.30.3
Stereotopy head waving bouts, day 30.10.10.40.3-0.2-0.6-0.3-0.3-0.3-0.30.1-0.0-0.1-0.0-0.2
Stereotopy head waving duration, day 30.30.40.9-0.40.70.40.90.90.90.90.2-0.0-0.1-0.00.7
Locomotion velocity, session 70.10.10.4-0.40.40.60.40.40.40.4-0.30.20.30.2-0.0
Locomotion distance, session 70.00.00.2-0.0-0.00.40.10.10.00.00.0-0.0-0.0-0.40.1
Stereotopy head waving bouts, day 71.01.12.2-1.01.00.60.80.80.80.8-1.21.31.21.5-1.2
Stereotopy head waving duration, day 71.11.42.9-1.11.10.70.80.80.80.8-1.51.41.51.7-1.4
Locomotion velocity, session 81.11.32.3-1.11.10.50.80.81.01.0-1.41.31.41.5-1.2
Locomotion distance, session 81.11.54.5-1.00.80.40.20.20.30.3-1.81.71.71.8-2.1
Degree of sensitization distance0.60.61.3-0.90.81.20.70.70.70.7-0.80.90.90.4-0.6
Degree of sensitization stereotypy0.91.02.5-0.90.70.50.40.40.30.3-1.41.31.41.6-1.6
Conditioned locomotion0.50.61.60.6-0.5-0.2-0.2-0.2-0.2-0.21.0-1.1-1.0-1.11.3
Cocaine response after cond. corrected0.91.01.81.0-1.2-1.1-1.3-1.3-1.4-1.40.7-0.6-0.7-0.7-0.1
Cocaine response after cond. not corrected0.50.61.20.7-0.9-0.8-1.0-1.0-1.1-1.10.3-0.3-0.4-0.4-0.3
Cocaine response before conditioning0.70.91.2-1.00.90.90.80.80.80.8-1.11.01.01.1-0.8
Saline control response0.30.40.7-0.80.70.80.50.50.60.6-0.80.80.70.5-0.6
Bone: connectivity density0.40.72.8-0.50.4-0.0-0.1-0.1-0.1-0.1-1.11.21.10.9-1.7
Bone: cortical apparent density1.01.42.51.1-1.1-0.7-0.9-0.9-0.8-0.81.5-1.4-1.5-1.61.4
Bone: cortical area0.10.20.80.00.10.20.30.30.40.40.5-0.4-0.5-0.70.9
Bone: cortical porosity2.02.13.81.5-1.7-1.7-2.0-2.0-1.9-1.90.8-1.0-0.7-0.3-0.2
Bone: cortical porosity1.82.03.41.5-1.7-1.6-1.8-1.8-1.8-1.80.9-1.1-0.8-0.40.0
Bone: cortical thickness1.83.04.51.8-1.8-1.3-1.5-1.5-1.4-1.42.0-2.1-2.0-2.01.8
Bone: cortical thickness4.45.16.52.5-2.6-2.3-2.5-2.5-2.5-2.52.0-2.2-2.0-2.21.0
Bone: cortical tissue density0.91.22.21.1-1.0-0.7-0.8-0.8-0.8-0.81.4-1.3-1.3-1.51.2
Condit. Reinf. active minus inactive responses1.41.62.31.3-1.4-1.0-1.5-1.5-1.5-1.51.0-0.9-1.1-1.40.3
Condit. Reinf. active-inactive response ratio0.91.01.41.0-1.1-0.9-1.1-1.1-1.1-1.11.0-0.8-1.0-1.20.3
Condit. Reinf. active responses1.01.22.01.1-1.3-0.8-1.3-1.3-1.4-1.40.8-0.8-0.9-1.10.2
Condit. Reinf. inactive responses0.00.00.10.1-0.20.1-0.2-0.2-0.2-0.20.1-0.2-0.1-0.20.2
Incentive salience index mean1.82.23.71.5-1.7-1.3-1.9-1.9-1.9-1.91.1-1.0-1.1-1.20.0
Condit. Reinf. lever presses2.12.85.61.6-2.0-1.7-2.3-2.3-2.4-2.40.8-0.8-0.7-0.6-0.7
Condit. Reinf. active minus inactive responses0.70.91.41.0-1.1-1.0-1.2-1.2-1.2-1.20.7-0.6-0.7-0.8-0.0
Condit. Reinf. active-inactive response ratio1.21.31.81.1-1.3-0.9-1.4-1.4-1.3-1.31.0-0.9-1.1-1.10.3
Condit. Reinf. active responses0.30.40.80.7-0.7-0.9-0.8-0.8-0.8-0.80.4-0.3-0.6-0.6-0.1
Condit. Reinf. inactive responses0.20.30.6-0.40.60.30.70.70.70.7-0.40.40.20.20.0
Condit. Reinf. lever presses0.20.31.10.3-0.20.20.10.10.10.10.7-0.7-0.7-0.81.0
Condit. Reinf. lever reinforcers received0.20.30.50.6-0.5-0.7-0.6-0.6-0.6-0.60.4-0.3-0.6-0.60.1
Conditioned reinforcement - actives0.90.91.8-1.01.10.80.80.80.80.8-1.11.31.10.9-0.9
Conditioned reinforcement - inactives2.12.34.3-1.81.52.11.71.71.31.3-1.51.41.41.5-0.8
Conditioned locomotion0.60.81.4-0.91.10.81.11.11.21.2-0.40.70.50.40.3
Patch foraging indifference point 0 sec1.93.14.11.9-2.0-1.6-1.8-1.8-1.9-1.91.7-1.7-1.8-1.80.7
Patch foraging indifference point AUC1.51.83.1-1.51.61.61.71.71.81.8-0.60.90.60.60.4
Delay disc. indifference point, 0s delay2.02.12.6-1.61.61.31.51.51.41.4-1.51.51.51.6-1.0
Delay disc. indifference point, 16s delay0.40.40.8-0.60.80.30.90.90.90.9-0.40.40.40.30.1
Delay disc. indifference point, 2s delay0.10.20.50.4-0.3-0.2-0.1-0.1-0.1-0.10.5-0.5-0.5-0.70.6
Delay disc. indifference point, 24s delay1.01.01.21.1-1.1-1.0-0.9-0.9-0.9-0.91.0-1.0-1.0-1.10.7
Delay disc. indifference point, 4s delay0.50.51.0-0.80.81.00.80.80.70.7-0.70.70.70.5-0.3
Delay disc. indifference point, 8s delay0.00.00.0-0.00.10.00.10.10.10.1-0.00.00.0-0.10.1
Indifference point function ln k6.08.312.13.3-3.3-3.5-3.2-3.2-3.4-3.42.3-2.5-2.3-2.20.6
Indifference point function log k6.08.312.13.3-3.3-3.5-3.2-3.2-3.4-3.42.3-2.5-2.3-2.20.6
Patch foraging total patch changes 0 sec1.32.02.71.6-1.7-1.2-1.4-1.4-1.5-1.51.5-1.4-1.5-1.50.6
Patch foraging total patch changes 12 sec1.01.32.9-1.41.21.71.41.41.31.3-0.70.90.70.7-0.1
Patch foraging total patch changes 18 sec0.30.40.9-0.80.60.90.70.70.60.6-0.30.50.30.4-0.1
Patch foraging total patch changes 24 sec0.30.40.8-0.50.70.70.90.90.90.90.10.1-0.1-0.10.5
Patch foraging total patch changes 6 sec1.11.63.4-1.41.31.81.71.71.61.6-0.50.60.60.30.3
Patch foraging time to switch 0 sec1.72.63.8-1.81.61.81.31.31.51.5-1.71.71.81.9-1.2
Patch foraging water rate 0 sec0.61.01.91.1-0.8-1.1-0.5-0.5-0.7-0.71.2-1.1-1.2-1.41.0
Patch foraging water rate 12 sec0.30.41.0-0.60.60.40.30.30.30.3-0.81.00.80.6-1.0
Patch foraging water rate 18 sec0.50.71.40.9-0.8-1.2-1.1-1.1-1.1-1.10.1-0.1-0.1-0.3-0.8
Patch foraging water rate 24 sec0.20.30.5-0.50.60.50.70.70.50.5-0.40.60.50.3-0.2
Patch foraging water rate 6 sec0.10.10.30.5-0.1-0.60.00.0-0.2-0.20.3-0.3-0.3-0.50.3
Seeking ratio, delayed vs. immediate footshock0.50.61.10.8-0.6-0.7-0.4-0.4-0.4-0.41.0-1.0-0.9-1.01.0
Distance traveled before self-admin0.40.40.9-0.60.80.50.90.90.90.9-0.10.10.20.10.6
Distance traveled after self-admin6.47.29.4-3.13.02.82.62.62.82.8-2.72.62.72.7-1.3
Extensor digitorum longus weight3.513.917.8-4.13.93.43.43.43.43.4-4.14.24.23.9-3.0
Bone: elastic displacement0.20.20.80.2-0.10.30.20.20.20.20.7-0.6-0.6-0.30.9
Bone: elastic work0.91.22.31.1-1.0-0.6-0.6-0.6-0.6-0.61.5-1.5-1.4-1.31.5
Bone: endosteal estimation3.16.79.4-2.93.02.83.13.13.03.0-2.12.32.11.9-0.8
Bone: endosteal perimeter3.16.58.9-2.93.02.62.92.93.03.0-2.22.42.11.8-0.9
Epididymis fat weight3.17.210.9-2.82.42.42.02.01.91.9-3.33.13.33.3-3.0
Delta time in closed arm before/after self-admin0.50.50.7-0.80.80.40.70.70.70.7-0.70.70.70.7-0.4
Delta time in open arm before/after self-admin1.01.02.2-1.11.01.50.90.90.80.8-0.91.10.91.0-0.7
Diff in mean of infusions in LGA sessions0.30.30.70.5-0.6-0.5-0.8-0.8-0.8-0.80.00.0-0.1-0.1-0.6
Delay discount exponential model param0.10.10.2-0.20.10.30.00.00.00.0-0.30.30.30.5-0.4
Extinction: sum of active levers before priming0.90.92.9-0.70.20.4-0.3-0.3-0.3-0.3-1.41.11.31.2-1.7
Active lever presses in extinction session 60.80.71.5-0.80.70.40.40.40.30.3-1.21.11.21.2-1.2
Bone: final force0.60.91.3-1.11.01.10.90.90.90.9-1.01.00.91.0-0.6
Bone: final moment0.71.11.7-1.21.11.31.11.11.11.1-0.91.00.91.1-0.5
Food consumed during 24 hour testing period0.70.92.21.1-1.0-1.5-1.0-1.0-1.1-1.10.6-0.6-0.6-0.7-0.0
Glucose0.81.23.9-0.20.41.41.11.11.11.10.8-0.9-0.8-0.92.0
Heart weight0.81.21.7-1.21.01.30.80.80.80.8-1.21.21.21.3-0.9
Delay discount hyperbolic model param0.00.00.1-0.10.00.1-0.1-0.1-0.1-0.1-0.20.20.20.4-0.4
Intermittent access intake day 1-15 change1.41.42.8-1.31.31.71.51.51.51.5-0.40.50.50.70.6
Intermittent access intake escalation1.21.12.0-1.11.21.41.41.41.41.4-0.30.30.40.50.7
Intermittent access intake escalation 20.50.51.5-0.30.60.70.90.90.90.90.3-0.3-0.3-0.21.2
Intermitt. access day 1 inactive lever presses0.40.41.2-0.30.21.00.80.80.60.60.4-0.5-0.3-0.21.1
Intermitt. access day 15 inactive lever presses0.10.10.20.3-0.50.1-0.4-0.4-0.5-0.50.3-0.4-0.2-0.30.0
Intermitt. access escalation Index0.50.41.9-0.2-0.0-0.1-0.4-0.4-0.4-0.4-0.70.80.70.8-1.4
Intermittent access day 1 total infusions2.12.43.0-1.71.61.61.51.51.41.4-1.71.71.61.5-1.2
Intermittent access day 15 total infusions5.86.58.6-2.92.92.92.92.92.92.9-2.12.22.12.2-0.6
Intermittent access terminal intake (last 3 days)4.54.96.3-2.52.52.42.32.32.32.3-2.22.22.22.1-1.2
Intermittent access total infusions3.23.54.5-2.12.12.12.02.02.02.0-1.81.81.81.7-0.8
Intermittent access day 1 locomotion3.13.24.2-2.02.01.92.02.01.81.8-1.71.81.71.7-0.9
Intermittent access day 15 total locomotion2.12.33.9-1.61.81.52.02.01.81.8-1.11.11.11.1-0.1
Intermittent access total locomotion1.71.92.6-1.51.61.51.61.61.51.5-1.21.31.31.2-0.5
Intermittent access standard deviation5.15.49.1-2.52.72.72.82.83.03.0-1.51.41.51.70.3
Left kidney weight0.10.20.4-0.50.50.30.20.20.70.7-0.20.20.30.30.1
Right kidney weight0.00.10.2-0.30.30.20.00.00.40.4-0.20.10.30.40.1
Cocaine induced anxiety1.61.92.41.5-1.3-1.2-1.3-1.3-1.1-1.11.5-1.5-1.5-1.51.3
Post-drug Anxiety0.70.81.00.9-1.0-0.4-0.8-0.8-1.0-1.00.9-0.8-0.9-0.90.5
Baseline Anxiety0.70.81.5-1.00.91.21.01.00.70.7-0.80.90.80.8-0.7
Tail length0.72.09.8-0.50.2-0.7-0.5-0.5-0.6-0.6-2.01.81.81.6-3.1
Length with tail0.41.66.50.2-0.4-1.3-1.1-1.1-1.2-1.2-1.21.11.21.1-2.6
Length without tail0.40.93.6-0.20.0-0.5-0.7-0.7-0.6-0.6-1.11.11.21.2-1.9
Times rat made contact with spout1.41.62.21.4-1.5-1.2-1.4-1.4-1.4-1.41.2-1.3-1.3-1.20.6
Lifetime Intake4.65.26.8-2.62.52.62.42.42.42.4-2.22.22.22.0-1.1
Liver weight, left0.20.30.80.4-0.4-0.8-0.7-0.7-0.7-0.7-0.20.30.30.2-0.9
Liver weight, right0.50.92.3-0.80.70.10.40.40.40.4-1.31.31.21.3-1.5
Locomotor activity0.71.21.6-1.21.11.30.90.91.01.0-1.21.21.21.1-0.8
Locomotor testing distance3.76.18.2-2.82.72.92.52.52.52.5-2.52.52.52.3-1.3
Locomotor testing rearing3.96.08.7-2.82.72.92.62.62.62.6-2.22.32.12.2-0.9
Locomotion in novel chamber1.72.13.9-1.21.61.92.02.01.91.9-0.20.30.30.11.4
Locomotion in novel chamber post-restriction0.30.30.60.5-0.5-0.2-0.3-0.3-0.3-0.30.8-0.7-0.8-0.70.8
Fecal boli incidents, locomotor time 10.50.61.10.9-0.7-1.1-0.8-0.8-0.7-0.70.7-0.6-0.7-0.80.4
Change in fecal boli incidents, locomotor task0.50.50.70.8-0.8-0.5-0.7-0.7-0.7-0.70.7-0.8-0.7-0.80.5
Time >=10cm from walls, locomotor time 10.30.40.50.7-0.7-0.7-0.5-0.5-0.6-0.60.5-0.7-0.5-0.60.2
Bouts of movement, locomotor time 10.91.01.51.1-1.1-1.2-1.2-1.2-1.2-1.20.6-0.7-0.6-0.90.1
Total resting periods, locomotor time 12.22.43.21.8-1.7-1.8-1.7-1.7-1.7-1.71.3-1.4-1.3-1.50.5
Rest time, locomotor task time 10.60.71.20.8-0.7-0.6-0.5-0.5-0.6-0.61.0-1.0-1.0-1.10.9
Distance moved, locomotor task time 11.31.41.9-1.31.21.31.11.11.11.1-1.21.21.21.4-0.7
Vertical activity count, locomotor time 11.31.41.9-1.31.21.31.11.11.01.0-1.31.21.31.4-0.9
Time >=10cm from walls, locomotor time 20.80.81.21.1-1.0-1.0-0.8-0.8-0.8-0.80.9-1.0-0.9-1.00.6
Bouts of movement, locomotor time 21.41.51.91.3-1.4-1.2-1.3-1.3-1.3-1.31.2-1.2-1.2-1.10.6
Total resting periods, locomotor time 21.01.01.31.1-1.1-1.2-1.2-1.2-1.1-1.10.9-0.9-0.9-0.80.3
Rest time, locomotor task time 21.01.21.51.2-1.1-1.2-0.9-0.9-1.0-1.01.1-1.1-1.2-1.20.8
Distance moved, locomotor task time 22.22.63.5-1.81.81.91.81.81.81.8-1.41.41.41.5-0.5
Vertical activity count, locomotor time 20.80.81.1-1.01.01.00.90.90.90.9-0.90.91.00.9-0.5
Light reinforcement 11.62.94.5-1.91.82.11.81.81.61.6-1.61.61.71.8-0.9
Light reinforcement 20.20.20.4-0.50.60.60.60.60.60.6-0.20.40.30.50.1
Bone: marrow area3.06.69.2-2.93.02.73.03.03.03.0-2.12.32.11.8-0.8
Bone: maximum diameter0.71.32.4-1.21.31.21.51.51.51.5-0.60.70.60.30.2
Bone: maximum force0.71.21.6-1.21.21.31.21.21.21.2-1.01.01.00.9-0.5
Bone: maximum moment0.91.52.3-1.41.31.51.41.41.41.4-1.01.01.01.0-0.3
Mean time between licks in bursts1.31.83.2-1.31.30.60.80.80.90.9-1.81.81.81.8-1.7
Mean num. licks in bursts0.10.10.30.3-0.4-0.5-0.5-0.5-0.5-0.50.1-0.1-0.10.1-0.3
Cd content in liver1.01.11.5-1.11.10.81.01.00.90.9-1.21.21.11.1-1.0
Co content in liver0.10.20.3-0.40.4-0.20.40.40.30.3-0.50.60.40.5-0.6
Cu content in liver2.83.34.52.1-2.1-1.8-1.9-1.9-2.0-2.01.7-1.9-1.8-1.60.9
Fe content in liver0.30.40.80.3-0.5-0.5-0.9-0.9-0.8-0.8-0.20.20.30.4-0.8
K content in liver0.30.31.10.4-0.4-1.0-0.7-0.7-0.6-0.6-0.30.20.20.3-0.8
Mg content in liver0.00.00.0-0.10.10.10.10.10.20.20.0-0.1-0.10.10.2
Mn content in liver1.92.23.41.6-1.6-1.8-1.8-1.8-1.6-1.61.2-1.2-1.2-1.10.3
Na content in liver0.10.10.2-0.20.30.20.30.30.40.40.0-0.1-0.0-0.10.4
Rb content in liver0.81.01.4-1.11.21.21.01.01.11.1-1.01.00.91.0-0.5
Se content in liver0.91.12.01.1-1.0-0.8-0.7-0.7-0.7-0.71.4-1.3-1.4-1.31.2
Sr content in liver1.71.62.2-1.41.31.11.11.11.11.1-1.51.51.51.3-1.2
Zn content in liver0.10.10.30.3-0.40.1-0.2-0.2-0.2-0.20.5-0.5-0.5-0.50.5
Bone: minimum diameter1.93.64.9-2.12.21.72.12.12.22.2-1.81.91.71.4-0.8
Time in familiar zone, hab. session 10.30.20.9-0.50.50.90.50.50.60.6-0.30.10.30.40.3
Time in novel zone, hab. session 10.40.41.30.8-0.6-1.1-0.6-0.6-0.6-0.60.6-0.3-0.6-0.8-0.1
Total zone transitions, hab. session 15.67.910.6-3.13.03.32.82.82.92.9-2.82.62.83.0-1.4
Total locomotion distance, hab. session 10.50.71.3-0.90.81.10.70.70.70.7-1.00.71.01.0-0.6
Locomotion velocity, hab. session 10.60.81.7-1.00.91.30.80.80.80.8-1.00.81.01.0-0.5
Time in familiar zone, hab. session 20.50.50.90.6-0.7-1.0-0.9-0.9-0.9-0.90.4-0.2-0.5-0.6-0.1
Time in novel zone, hab. session 20.10.10.60.2-0.10.30.20.20.20.20.5-0.6-0.4-0.40.7
Total zone transitions, hab. session 22.53.34.6-2.01.81.91.51.51.51.5-2.11.92.12.1-1.4
Total locomotion distance, hab. session 20.50.61.0-0.90.71.00.60.60.60.6-1.00.81.01.0-0.6
Locomotion velocity, hab. session 20.50.71.1-1.00.81.00.70.70.70.7-1.00.81.01.1-0.6
Novel to familiar place preference ratio0.20.20.4-0.30.40.60.60.60.40.4-0.00.0-0.0-0.00.3
Novelty place preference0.00.00.1-0.10.10.30.30.30.10.10.00.0-0.1-0.10.1
Time in novel zone, NPP test0.00.00.0-0.00.00.20.20.2-0.0-0.00.00.1-0.1-0.1-0.0
Total zone transitions, NPP test3.54.97.2-2.52.22.72.02.02.12.1-2.42.12.42.5-1.4
Total locomotion distance, NPP test0.40.61.7-0.80.71.30.80.80.80.8-0.50.30.50.60.2
Locomotion velocity, NPP test0.30.51.7-0.70.61.30.90.90.80.8-0.1-0.00.20.30.6
Intraocular pressure1.42.04.5-1.61.62.11.71.71.81.8-0.60.90.50.50.4
Delta distance traveled before/after self-admin3.94.26.1-2.32.02.21.41.41.51.5-2.42.42.42.5-2.0
Delta ambulatory time before/after self-admin2.52.84.1-1.91.61.91.11.11.21.2-2.02.02.02.0-1.7
Parametrial fat weight9.017.528.9-4.33.93.22.72.72.72.7-5.35.45.25.1-5.2
Pavlov. Cond. lever latency2.43.14.5-1.92.11.42.12.12.12.1-1.61.61.51.4-0.6
Pavlov. Cond. magazine entry latency4.15.37.82.5-2.7-2.5-2.8-2.8-2.8-2.81.8-1.8-1.7-1.70.3
Pavlov. Cond. change in total contacts2.22.43.21.6-1.8-0.8-1.5-1.5-1.6-1.61.7-1.8-1.6-1.61.2
Pavlov. Cond. index score2.73.55.72.0-2.2-1.8-2.4-2.4-2.4-2.41.4-1.4-1.3-1.20.1
Pavlov. Cond. latency score3.03.96.52.1-2.3-2.0-2.5-2.5-2.5-2.51.4-1.4-1.3-1.20.0
Pavlov. Cond. lever contacts1.82.13.51.5-1.8-1.0-1.8-1.8-1.9-1.91.2-1.3-1.0-0.90.3
Pavlov. Cond. magazine entry number2.22.73.9-1.71.91.52.02.02.02.0-1.51.41.41.4-0.5
Pavlov. Cond. intertrial magazine entries3.74.56.9-2.42.32.62.42.42.32.3-1.91.81.91.7-0.7
Pavlov. Cond. lever-magazine prob. diff.2.63.25.21.9-2.1-1.7-2.2-2.2-2.3-2.31.4-1.4-1.3-1.20.2
Pavlov. Cond. response bias2.53.14.81.8-2.1-1.5-2.1-2.1-2.2-2.21.5-1.5-1.4-1.20.4
Pavlov. Cond. lever latency1.11.53.6-1.11.00.40.50.50.50.5-1.61.71.61.8-1.9
Pavlov. Cond. magazine entry latency0.91.01.71.1-1.0-0.8-0.9-0.9-0.7-0.71.3-1.2-1.2-1.31.0
Pavlov. Cond. change in total contacts0.71.01.91.0-0.9-0.8-0.8-0.8-0.7-0.71.2-1.2-1.2-1.41.1
Pavlov. Cond. index score0.70.93.00.7-0.5-0.1-0.1-0.10.00.01.4-1.3-1.3-1.41.7
Pavlov. Cond. latency score0.81.03.60.7-0.4-0.0-0.0-0.00.10.11.5-1.3-1.4-1.51.9
Pavlov. Cond. lever contacts0.30.51.40.5-0.40.0-0.0-0.0-0.1-0.10.9-0.9-0.9-1.11.2
Pavlov. Cond. magazine entry number0.60.71.5-0.80.60.50.50.50.30.3-1.21.01.11.2-1.1
Pavlov. Cond. intertrial magazine entries0.81.12.0-1.10.90.90.70.70.60.6-1.41.31.41.3-1.2
Pavlov. Cond. lever-magazine prob. diff.0.81.03.00.8-0.5-0.2-0.2-0.2-0.1-0.11.4-1.3-1.4-1.41.7
Pavlov. Cond. response bias0.60.81.80.9-0.7-0.3-0.4-0.4-0.4-0.41.2-1.2-1.2-1.31.3
Time in closed arm before self-admin0.70.81.90.7-1.1-0.6-1.4-1.4-1.3-1.30.3-0.3-0.3-0.3-0.6
Time in closed arm after self-admin0.10.10.20.3-0.4-0.5-0.4-0.4-0.3-0.30.2-0.3-0.3-0.30.1
Time in open arm before self-admin0.60.72.50.7-0.4-0.4-0.1-0.1-0.0-0.01.1-1.2-1.0-1.21.6
Time in open arm after self-admin1.21.33.1-1.11.31.81.41.41.41.4-0.40.50.40.40.6
Bone: periosteal estimation1.42.94.4-1.92.01.92.12.12.12.1-1.21.41.20.9-0.2
Bone: periosteal perimeter0.81.32.3-1.31.41.11.41.41.51.5-0.81.00.60.4-0.1
Bone: post-yield work0.30.41.2-0.50.40.30.20.20.10.1-0.80.90.90.8-1.1
Progressive ratio test 1 active lever presses1.21.22.2-1.21.10.80.90.90.80.8-1.51.31.31.2-1.2
Progressive ratio test 1 breakpoint1.51.62.9-1.41.10.90.80.80.80.8-1.71.61.61.5-1.6
Progressive ratio test 1 inactive lever presses1.82.02.6-1.61.51.61.41.41.41.4-1.41.31.41.4-0.7
Progressive ratio test 2 active lever presses0.80.91.4-1.11.01.00.70.70.80.8-1.21.11.11.1-0.8
Progressive ratio test 2 breakpoint0.50.60.9-0.80.70.70.40.40.60.6-1.00.90.90.9-0.7
Progressive ratio test 2 inactive lever presses3.03.46.0-2.11.92.52.02.01.91.9-1.81.61.71.6-0.9
Incentive Sensitization - Responses0.20.20.3-0.50.30.60.10.10.30.3-0.60.50.60.5-0.4
Incentive Sensitization - Breakpoint0.20.20.4-0.50.30.60.10.10.30.3-0.50.50.60.5-0.4
Sum of active levers in priming session hrs 5-60.60.61.90.3-0.5-0.5-1.0-1.0-1.0-1.0-0.50.50.50.4-1.4
Progressive ratio0.50.61.3-0.90.91.10.90.90.90.9-0.50.60.50.50.1
Food seeking constrained by brief footshock0.10.20.30.5-0.3-0.6-0.4-0.4-0.3-0.30.5-0.5-0.5-0.40.4
Seeking ratio, punishment vs. effort0.91.12.21.3-1.1-1.5-1.1-1.1-1.1-1.10.9-1.0-0.9-0.90.3
Retroperitoneal fat weight0.31.01.9-1.01.01.41.21.21.11.1-0.80.60.91.0-0.0
Reaction time number correct0.10.20.4-0.20.30.10.40.40.20.2-0.60.50.60.3-0.6
Reaction time mean minus median0.50.61.70.6-0.60.2-0.3-0.3-0.4-0.41.1-1.0-1.1-1.11.3
Reaction time mean minus median AUC0.10.20.50.2-0.20.40.00.0-0.1-0.10.5-0.4-0.5-0.60.7
Reaction time num false alarms1.21.62.51.2-1.3-0.8-1.0-1.0-1.0-1.01.5-1.5-1.6-1.61.3
Reaction time num false alarms AUC0.81.11.81.1-1.0-0.7-0.8-0.8-0.7-0.71.3-1.3-1.3-1.41.2
Reaction time trials correct on left0.10.20.4-0.20.30.10.40.40.20.2-0.60.50.60.3-0.6
Reaction time trials on left0.10.20.4-0.20.40.10.40.40.20.2-0.60.50.60.3-0.6
Reaction time mean0.20.30.60.5-0.5-0.1-0.5-0.5-0.4-0.40.8-0.7-0.7-0.70.8
Reaction time mean AUC0.50.71.40.7-0.7-0.2-0.5-0.5-0.5-0.51.1-1.0-1.1-1.01.2
Median of all reaction times0.10.10.30.2-0.30.0-0.3-0.3-0.2-0.20.5-0.4-0.4-0.30.5
Reaction time omissions0.40.61.0-0.80.91.00.90.90.90.9-0.50.70.50.6-0.1
Reaction time false alarm rate0.81.11.81.0-1.1-0.6-0.9-0.9-0.7-0.71.3-1.3-1.4-1.31.3
Reaction time premature initiation rate1.62.13.41.7-1.6-1.8-1.6-1.6-1.7-1.71.3-1.1-1.3-1.10.2
Reaction time premature initiations1.01.42.81.4-1.3-1.7-1.3-1.3-1.4-1.40.8-0.7-0.9-0.8-0.1
Std. dev. reaction times1.11.52.61.2-1.2-0.5-0.9-0.9-0.9-0.91.6-1.5-1.6-1.61.6
Reaction time trials completed0.10.20.4-0.20.40.10.40.40.20.2-0.60.50.60.3-0.6
Reaction time trials AUC0.10.10.3-0.20.30.00.40.40.10.1-0.50.40.50.2-0.6
Run reversals in cocaine runway, females0.10.10.10.2-0.3-0.0-0.3-0.3-0.3-0.30.3-0.3-0.3-0.20.3
Run reversals in cocaine runway, males3.02.94.9-1.81.92.22.12.12.02.0-1.21.01.21.40.1
Latency to leave start box in cocaine runway0.20.20.40.5-0.5-0.7-0.5-0.5-0.5-0.50.4-0.4-0.4-0.30.0
Latency to leave start box in cocaine runway, F0.50.61.10.7-0.8-1.1-1.0-1.0-1.0-1.00.4-0.3-0.4-0.3-0.4
Latency to leave start box in cocaine runway, M0.30.20.3-0.50.50.30.60.60.50.5-0.50.50.50.6-0.3
Std. dev. time between licks in bursts0.50.50.9-0.70.70.40.50.50.50.5-1.01.01.00.8-0.9
Total sessions with >9 infusions2.42.63.5-1.91.71.51.31.31.51.5-1.91.91.81.7-1.3
Short access day 1 total inactive lever presses0.30.40.9-0.70.50.90.80.80.40.4-0.60.40.50.5-0.2
Short access day 10 total inactive lever presses0.00.00.10.3-0.3-0.1-0.2-0.2-0.2-0.20.1-0.3-0.10.00.0
Short access day 1 total infusions3.74.05.9-2.32.22.42.32.32.32.3-1.61.51.51.5-0.2
Short access day 10 total infusions1.92.13.3-1.71.61.81.41.41.41.4-1.51.51.51.3-0.8
Short access total infusions4.75.38.1-2.72.62.82.52.52.52.5-2.02.12.01.9-0.7
Short access day 1 locomotion1.21.32.4-1.31.31.61.41.41.41.4-0.70.80.70.80.1
Short access day 10 total locomotion1.41.52.4-1.31.41.41.61.61.51.5-0.70.90.81.0-0.0
Short access total locomotion1.11.21.8-1.21.31.11.31.31.41.4-0.70.90.80.9-0.1
One hour access (0.3 mA shock)2.02.33.1-1.71.71.81.61.61.51.5-1.51.61.51.5-0.8
Compulsive drug intake1.01.01.51.1-1.2-1.0-1.1-1.1-1.2-1.20.8-0.8-0.8-0.70.1
One hour access (shock baseline)2.73.14.3-2.02.11.81.81.81.91.9-1.71.81.71.6-0.9
Social response proportion1.61.73.61.1-1.4-1.3-1.8-1.8-1.9-1.90.0-0.1-0.00.2-1.4
Social responses1.41.83.6-1.31.01.30.70.70.60.6-1.71.81.71.8-1.9
Social time0.81.13.0-0.90.60.70.30.30.10.1-1.41.41.41.5-1.7
Soleus weight1.64.614.7-1.61.3-0.10.10.10.20.2-3.03.02.93.1-3.8
Bone: stiffness1.52.34.6-1.51.20.80.70.70.70.7-2.12.02.02.1-2.2
Tibialis anterior weight3.110.517.3-3.43.12.52.22.22.22.2-4.24.04.13.8-3.7
Time to tail flick, vehicle, before self-admin0.30.31.20.2-0.5-0.5-0.6-0.6-0.7-0.7-0.50.20.50.4-1.1
Time to tail flick, vehicle, after self-admin0.20.20.4-0.50.40.70.40.40.30.3-0.40.40.40.4-0.2
Time to tail flick, test, before self-admin4.44.36.22.2-2.3-2.1-2.5-2.5-2.4-2.41.7-1.6-1.8-1.80.5
Time to tail flick, test, after self-admin1.21.32.21.2-1.3-1.2-1.5-1.5-1.4-1.40.7-0.9-0.7-0.80.1
Delta time to tail flick, vehicle, before/after SA1.01.01.9-1.01.21.41.31.31.31.3-0.20.50.30.30.6
Delta time to tail flick, test, before/after SA1.61.41.9-1.31.31.11.41.41.31.3-1.10.91.11.1-0.4
Tibia length0.82.35.61.6-1.6-2.4-2.0-2.0-1.9-1.90.4-0.5-0.7-0.5-0.8
Ambulatory time before self-admin0.20.20.5-0.20.30.10.50.50.50.50.2-0.2-0.2-0.20.7
Ambulatory time after self-admin2.93.14.4-2.01.81.71.41.41.51.5-2.12.02.12.1-1.5
Bone: tissue strength0.20.20.8-0.40.40.90.60.60.60.60.1-0.10.00.20.5
Total heroin consumption0.80.93.10.3-0.7-0.6-1.1-1.1-1.2-1.2-0.70.60.70.6-1.7
Bone: trabecular number0.30.50.80.5-0.6-0.9-0.9-0.9-0.9-0.90.00.1-0.0-0.2-0.9
Bone: trabecular spacing0.20.30.6-0.50.60.70.80.80.80.8-0.20.10.20.40.4
Bone: trabecular thickness0.10.10.3-0.20.20.00.10.10.00.0-0.60.50.50.3-0.6
Bone: trabecular tissue density1.21.73.51.3-1.2-0.6-0.8-0.8-0.8-0.81.7-1.9-1.6-1.41.8
Water consumed over 24 hours4.35.28.32.6-2.5-2.9-2.6-2.6-2.4-2.42.0-2.0-2.0-1.90.6
Number of responses in last shaping day0.60.61.7-0.90.91.31.01.00.90.9-0.40.30.30.50.4