Hub : Genes

Med26

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Med26 0.11 0.11 9.0e-03 0 0.01 0.02 0.01 7.7e-02 1.4e-02 5.4e-03 5.6e-02
2 Brain alternative polyA NM_001107300.3 0.05 0.03 3.7e-05 0.06 0.01 0.05 -0 4.2e-06 1.2e-02 1.2e-05 7.7e-01
3 Brain alternative polyA XM_039094481.1 0.05 0.03 3.8e-05 0.06 0.02 0.05 -0 4.5e-06 1.1e-02 1.5e-05 7.7e-01
4 NAcc isoform ratio NM_001107300.3 0.05 0.04 4.4e-05 0.04 0.03 0.03 0.03 8.2e-06 1.8e-04 2.9e-04 1.3e-04
5 Brain isoform ratio NM_001107300.3 0.04 0.03 6.6e-04 0.04 0.01 0.02 0.01 1.5e-04 2.3e-02 2.3e-03 7.6e-02
6 OFC alternative TSS XM_006252800.4 0.53 0.23 1.6e-03 0.08 0.08 0.08 0.08 6.4e-03 5.0e-03 5.6e-03 7.1e-03
7 NAcc alternative polyA XM_039094481.1 0.05 0.03 4.3e-05 0.02 0.02 0.03 0.01 6.8e-04 9.2e-04 4.4e-04 8.7e-03
8 NAcc alternative polyA NM_001107300.3 0.04 0.03 1.2e-04 0.02 0.02 0.03 0.01 1.6e-03 4.1e-03 6.0e-04 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.11.96.2-0.9-1.31.3-1.0-1.1-2.51.1-1.1
Area under the delay curve0.30.30.90.50.4-0.40.40.40.9-0.40.5
BMI with tail0.10.21.2-0.6-0.00.0-0.1-0.3-1.10.10.0
BMI without tail0.40.81.3-0.61.2-1.21.10.80.3-0.80.9
Body weight0.31.25.8-0.2-0.80.8-0.6-0.8-2.41.0-0.8
Weight adjusted by age0.40.52.3-1.50.4-0.40.60.6-0.8-0.10.1
Bone surface1.42.55.9-0.1-1.71.7-1.5-1.5-2.41.4-1.4
Bone volume1.01.65.8-1.0-1.21.2-0.9-1.0-2.40.9-0.8
Breakpoint value in progressive ratio session0.91.01.50.1-1.11.1-1.2-1.2-0.91.1-1.1
Number of licking bursts0.20.20.40.40.3-0.30.60.30.6-0.60.6
Context. condit. distance diff. score0.00.10.3-0.20.2-0.20.2-0.1-0.5-0.10.0
Locomotion velocity, session 15.35.87.80.7-2.52.5-2.4-2.4-2.52.7-2.8
Locomotion distance, session 14.76.07.61.1-2.82.8-2.6-2.6-2.02.6-2.7
Locomotion velocity, session 20.40.51.7-0.6-0.40.4-0.3-0.4-1.30.7-0.7
Locomotion distance, session 22.73.85.00.8-2.22.2-2.1-2.2-1.52.1-2.1
Locomotion velocity, session 30.10.20.2-0.4-0.50.5-0.4-0.4-0.50.3-0.4
Locomotion distance, session 31.01.01.6-1.2-1.01.0-1.0-1.1-1.30.7-0.6
Stereotopy head waving bouts, day 30.40.40.60.6-0.80.8-0.5-0.6-0.60.6-0.6
Stereotopy head waving duration, day 30.20.20.30.3-0.50.5-0.4-0.3-0.40.5-0.6
Locomotion velocity, session 70.70.84.1-2.00.2-0.20.1-0.20.2-0.81.1
Locomotion distance, session 70.40.51.5-0.80.6-0.60.30.10.5-1.01.2
Stereotopy head waving bouts, day 72.02.23.20.2-1.61.6-1.5-1.5-1.41.7-1.8
Stereotopy head waving duration, day 70.70.81.2-0.2-0.90.9-0.9-0.8-1.01.0-1.1
Locomotion velocity, session 82.83.44.90.8-1.81.8-1.7-1.8-2.12.1-2.2
Locomotion distance, session 82.03.03.70.9-1.81.8-1.8-1.9-1.91.7-1.7
Degree of sensitization distance1.11.12.10.21.0-1.00.90.91.4-1.21.4
Degree of sensitization stereotypy1.01.11.5-0.2-1.11.1-1.1-1.1-1.11.2-1.2
Conditioned locomotion0.10.10.2-0.10.2-0.20.40.4-0.0-0.20.1
Cocaine response after cond. corrected3.23.64.7-1.02.1-2.12.12.22.1-1.81.7
Cocaine response after cond. not corrected1.31.52.2-1.01.2-1.21.41.51.1-1.11.1
Cocaine response before conditioning2.73.24.30.5-2.02.0-1.9-1.9-2.11.9-1.8
Saline control response1.11.42.11.0-1.01.0-1.0-1.2-1.41.4-1.3
Bone: connectivity density1.42.13.40.8-1.51.5-1.3-1.2-1.91.6-1.6
Bone: cortical apparent density0.10.20.80.90.3-0.30.10.10.40.4-0.5
Bone: cortical area1.11.66.5-2.50.5-0.50.70.6-2.0-0.80.8
Bone: cortical porosity0.91.01.50.3-1.21.2-1.2-1.2-1.10.8-0.7
Bone: cortical porosity1.41.52.4-0.1-1.41.4-1.5-1.5-1.40.9-0.8
Bone: cortical thickness0.91.56.9-2.10.0-0.00.20.1-2.6-0.40.4
Bone: cortical thickness1.01.14.5-2.1-0.00.00.30.1-2.0-0.50.5
Bone: cortical tissue density0.20.20.80.90.4-0.40.10.10.50.4-0.5
Condit. Reinf. active minus inactive responses0.91.01.30.8-1.01.0-1.1-1.1-1.20.9-0.9
Condit. Reinf. active-inactive response ratio0.10.10.6-0.3-0.30.3-0.3-0.3-0.70.1-0.1
Condit. Reinf. active responses1.31.62.01.0-1.31.3-1.4-1.4-1.21.2-1.2
Condit. Reinf. inactive responses0.40.50.80.8-0.90.9-0.7-0.5-0.10.7-0.6
Incentive salience index mean3.44.15.41.6-2.12.1-2.1-2.1-2.31.9-2.0
Condit. Reinf. lever presses6.38.49.92.2-3.13.1-3.0-3.0-3.12.8-2.8
Condit. Reinf. active minus inactive responses0.30.40.8-0.0-0.70.7-0.7-0.6-0.90.6-0.5
Condit. Reinf. active-inactive response ratio0.20.20.7-0.7-0.10.10.20.2-0.8-0.20.3
Condit. Reinf. active responses0.50.71.00.9-0.80.8-0.9-0.8-0.51.0-1.0
Condit. Reinf. inactive responses0.81.05.12.3-0.20.2-0.5-0.31.10.8-0.9
Condit. Reinf. lever presses0.00.10.10.10.2-0.20.40.4-0.3-0.20.3
Condit. Reinf. lever reinforcers received0.10.10.70.8-0.10.1-0.2-0.00.10.4-0.3
Conditioned reinforcement - actives0.90.94.0-2.00.9-0.90.90.90.2-0.10.1
Conditioned reinforcement - inactives5.56.229.5-5.41.9-1.92.02.0-0.4-1.51.5
Conditioned locomotion2.42.83.7-1.71.9-1.91.81.80.9-1.61.6
Patch foraging indifference point 0 sec0.40.65.02.20.1-0.1-0.10.00.00.1-0.2
Patch foraging indifference point AUC0.70.85.12.30.3-0.30.30.30.90.5-0.5
Delay disc. indifference point, 0s delay0.20.21.30.70.0-0.00.10.01.1-0.20.3
Delay disc. indifference point, 16s delay1.31.32.90.41.0-1.01.21.11.7-1.21.3
Delay disc. indifference point, 2s delay0.60.61.10.7-0.90.9-1.0-1.0-0.30.6-0.6
Delay disc. indifference point, 24s delay0.70.60.90.30.8-0.80.90.91.0-0.70.7
Delay disc. indifference point, 4s delay0.50.50.91.0-0.70.7-0.5-0.6-0.60.7-0.7
Delay disc. indifference point, 8s delay0.90.92.8-0.30.8-0.80.90.91.7-0.80.9
Indifference point function ln k1.42.07.3-2.71.0-1.01.01.2-0.0-1.41.5
Indifference point function log k1.42.07.3-2.71.0-1.01.01.2-0.0-1.41.5
Patch foraging total patch changes 0 sec0.30.63.51.90.5-0.50.40.50.2-0.20.1
Patch foraging total patch changes 12 sec0.60.85.52.40.0-0.00.20.20.30.4-0.5
Patch foraging total patch changes 18 sec1.62.112.63.5-0.60.6-0.6-0.70.71.0-1.0
Patch foraging total patch changes 24 sec1.51.87.32.7-0.90.9-0.7-0.9-0.21.4-1.4
Patch foraging total patch changes 6 sec0.81.38.72.90.0-0.0-0.0-0.00.50.7-0.8
Patch foraging time to switch 0 sec0.50.70.90.7-1.01.0-0.9-0.9-0.10.9-0.9
Patch foraging water rate 0 sec0.10.20.5-0.40.4-0.40.30.4-0.7-0.40.4
Patch foraging water rate 12 sec0.50.82.4-1.60.7-0.70.80.7-0.5-0.80.8
Patch foraging water rate 18 sec0.50.72.0-0.6-0.90.9-0.9-0.9-1.40.2-0.2
Patch foraging water rate 24 sec0.81.13.6-0.2-0.90.9-1.2-1.0-1.90.6-0.6
Patch foraging water rate 6 sec0.81.22.0-1.41.0-1.00.91.0-0.5-1.31.3
Seeking ratio, delayed vs. immediate footshock0.50.60.90.11.0-1.00.90.90.6-0.70.7
Distance traveled before self-admin0.20.20.9-0.5-0.10.1-0.4-0.5-0.90.3-0.2
Distance traveled after self-admin0.70.82.2-0.1-0.70.7-0.8-0.9-1.51.0-1.0
Extensor digitorum longus weight0.20.74.0-2.0-0.20.2-0.0-0.2-1.3-0.00.1
Bone: elastic displacement1.41.62.10.5-1.21.2-1.5-1.3-1.31.5-1.4
Bone: elastic work0.10.10.90.0-0.00.0-0.00.1-1.00.3-0.3
Bone: endosteal estimation0.71.42.3-0.91.2-1.21.21.21.5-1.11.1
Bone: endosteal perimeter0.51.11.4-0.91.1-1.11.21.21.0-1.01.0
Epididymis fat weight0.20.52.61.60.6-0.60.60.70.00.2-0.1
Delta time in closed arm before/after self-admin0.40.41.6-0.10.3-0.30.40.41.3-0.70.7
Delta time in open arm before/after self-admin1.31.21.71.0-1.21.2-1.1-1.1-0.71.3-1.3
Diff in mean of infusions in LGA sessions0.20.20.40.1-0.30.3-0.4-0.5-0.60.6-0.5
Delay discount exponential model param0.20.20.4-0.3-0.30.3-0.4-0.4-0.60.4-0.5
Extinction: sum of active levers before priming3.53.54.70.3-2.22.2-2.1-2.1-1.32.0-1.9
Active lever presses in extinction session 60.10.10.2-0.20.2-0.2-0.1-0.20.1-0.40.4
Bone: final force1.82.98.0-2.81.5-1.51.61.5-1.1-1.71.7
Bone: final moment2.13.58.2-2.91.7-1.71.81.7-0.7-1.91.9
Food consumed during 24 hour testing period1.31.62.80.7-1.41.4-1.6-1.7-1.20.9-0.7
Glucose0.10.10.4-0.70.3-0.30.40.30.1-0.30.4
Heart weight0.20.31.0-1.00.4-0.40.60.5-0.4-0.40.3
Delay discount hyperbolic model param0.00.00.2-0.4-0.00.0-0.0-0.0-0.20.1-0.2
Intermittent access intake day 1-15 change0.50.51.7-0.6-0.50.5-0.6-0.7-1.30.5-0.6
Intermittent access intake escalation0.70.72.0-0.9-0.60.6-0.6-0.6-1.40.7-0.7
Intermittent access intake escalation 20.70.72.5-1.6-0.70.7-0.5-0.6-0.90.6-0.6
Intermitt. access day 1 inactive lever presses0.20.21.0-1.00.2-0.20.40.5-0.40.2-0.2
Intermitt. access day 15 inactive lever presses0.30.30.9-1.0-0.20.2-0.2-0.2-0.90.7-0.6
Intermitt. access escalation Index0.20.21.41.2-0.00.0-0.0-0.0-0.0-0.10.1
Intermittent access day 1 total infusions5.56.38.5-2.02.9-2.92.72.72.3-2.32.2
Intermittent access day 15 total infusions2.02.34.2-2.01.7-1.71.61.60.7-1.21.2
Intermittent access terminal intake (last 3 days)1.92.14.4-2.11.6-1.61.31.20.8-1.31.2
Intermittent access total infusions3.33.75.3-2.12.3-2.32.12.11.4-1.41.4
Intermittent access day 1 locomotion3.53.75.2-1.62.2-2.22.32.21.3-1.71.7
Intermittent access day 15 total locomotion0.10.20.4-0.00.6-0.60.30.30.4-0.20.2
Intermittent access total locomotion2.12.43.9-1.62.0-2.01.71.70.9-1.11.1
Intermittent access standard deviation0.90.95.3-2.30.8-0.80.60.6-0.2-0.40.3
Left kidney weight0.72.02.81.4-1.41.4-1.3-1.2-1.41.7-1.5
Right kidney weight0.61.74.42.1-1.11.1-1.1-0.9-0.81.5-1.3
Cocaine induced anxiety0.20.30.60.80.6-0.60.50.50.6-0.10.2
Post-drug Anxiety0.20.21.21.1-0.10.1-0.2-0.20.40.5-0.5
Baseline Anxiety0.40.40.70.8-0.60.6-0.7-0.70.50.7-0.7
Tail length0.00.10.40.50.0-0.00.30.2-0.60.3-0.2
Length with tail0.51.85.30.6-1.21.2-0.9-0.9-2.31.6-1.5
Length without tail1.53.25.70.8-1.81.8-1.7-1.6-2.41.9-1.9
Times rat made contact with spout0.10.10.20.4-0.20.2-0.3-0.4-0.2-0.10.1
Lifetime Intake3.43.95.7-2.42.3-2.32.12.11.3-1.51.4
Liver weight, left0.91.52.11.0-1.41.4-1.4-1.4-0.51.2-1.2
Liver weight, right1.01.61.91.3-1.31.3-1.3-1.3-0.91.4-1.3
Locomotor activity2.33.65.81.7-2.02.0-2.2-2.4-1.91.4-1.4
Locomotor testing distance0.81.32.61.2-1.21.2-1.3-1.6-1.20.5-0.4
Locomotor testing rearing4.06.310.33.2-2.62.6-2.6-3.0-1.81.9-1.8
Locomotion in novel chamber0.20.30.80.9-0.40.4-0.4-0.4-0.00.6-0.6
Locomotion in novel chamber post-restriction4.35.16.51.2-2.62.6-2.5-2.5-2.02.2-2.2
Fecal boli incidents, locomotor time 11.11.23.10.21.0-1.00.70.81.8-1.31.3
Change in fecal boli incidents, locomotor task0.20.20.80.90.2-0.20.40.30.5-0.10.1
Time >=10cm from walls, locomotor time 10.50.51.81.20.2-0.20.40.41.4-0.30.3
Bouts of movement, locomotor time 10.30.30.91.0-0.40.4-0.4-0.40.10.7-0.7
Total resting periods, locomotor time 10.30.31.11.0-0.50.5-0.5-0.50.30.6-0.6
Rest time, locomotor task time 10.80.91.3-0.80.8-0.81.11.00.7-1.11.1
Distance moved, locomotor task time 10.10.10.30.40.0-0.0-0.3-0.20.20.5-0.5
Vertical activity count, locomotor time 10.70.71.5-0.2-0.70.7-0.9-0.8-1.20.9-0.9
Time >=10cm from walls, locomotor time 21.71.82.3-1.21.5-1.51.11.11.3-1.41.4
Bouts of movement, locomotor time 20.91.01.51.1-1.01.0-1.2-1.1-0.80.7-0.7
Total resting periods, locomotor time 20.90.91.31.0-1.11.1-1.1-1.0-0.60.7-0.7
Rest time, locomotor task time 20.10.10.5-0.2-0.60.60.1-0.1-0.70.1-0.1
Distance moved, locomotor task time 21.01.22.4-0.51.5-1.50.91.01.5-0.60.6
Vertical activity count, locomotor time 20.30.41.2-1.10.7-0.70.30.4-0.0-0.60.5
Light reinforcement 10.10.20.50.20.4-0.40.20.30.7-0.60.6
Light reinforcement 21.82.43.9-0.11.8-1.81.51.72.0-1.41.4
Bone: marrow area0.51.22.1-0.81.1-1.11.11.11.5-1.01.0
Bone: maximum diameter0.71.23.7-1.90.8-0.80.90.9-0.9-1.01.0
Bone: maximum force0.91.65.4-2.30.7-0.70.80.7-1.7-1.01.1
Bone: maximum moment1.01.85.7-2.41.0-1.01.00.9-1.2-1.21.3
Mean time between licks in bursts0.30.40.80.40.8-0.80.80.90.1-0.50.5
Mean num. licks in bursts0.20.30.6-0.2-0.40.4-0.8-0.5-0.70.5-0.5
Cd content in liver3.43.75.0-1.72.2-2.22.12.11.2-1.91.7
Co content in liver0.00.00.2-0.2-0.10.1-0.0-0.0-0.40.2-0.2
Cu content in liver4.55.48.32.0-2.32.3-2.2-2.4-1.92.7-2.9
Fe content in liver0.30.41.0-0.2-0.60.6-0.6-0.5-0.40.9-1.0
K content in liver0.40.42.31.5-0.30.3-0.2-0.40.60.3-0.3
Mg content in liver0.30.30.60.30.6-0.60.60.50.8-0.50.4
Mn content in liver0.40.51.20.5-0.50.5-0.5-0.7-0.41.0-1.1
Na content in liver2.42.53.31.8-1.61.6-1.7-1.6-0.51.8-1.8
Rb content in liver3.34.25.2-1.62.3-2.32.32.11.3-2.22.1
Se content in liver0.40.51.41.2-0.40.4-0.5-0.8-0.60.5-0.6
Sr content in liver0.50.40.90.4-0.60.6-0.8-0.50.10.9-0.9
Zn content in liver0.10.10.40.6-0.10.10.10.10.30.0-0.0
Bone: minimum diameter0.40.72.5-1.60.7-0.70.70.7-0.5-0.60.7
Time in familiar zone, hab. session 10.30.31.81.4-0.00.0-0.1-0.1-0.20.4-0.5
Time in novel zone, hab. session 10.30.31.9-1.40.1-0.10.20.1-0.1-0.50.6
Total zone transitions, hab. session 11.21.62.10.4-1.51.5-1.4-1.3-1.01.4-1.4
Total locomotion distance, hab. session 12.84.05.71.1-2.42.4-2.3-2.2-1.32.0-2.0
Locomotion velocity, hab. session 12.63.75.21.1-2.32.3-2.2-2.1-1.11.9-1.9
Time in familiar zone, hab. session 20.10.10.3-0.30.0-0.00.00.2-0.50.1-0.2
Time in novel zone, hab. session 20.40.41.0-0.10.6-0.60.70.51.0-0.70.8
Total zone transitions, hab. session 20.10.20.3-0.4-0.50.5-0.6-0.5-0.20.3-0.4
Total locomotion distance, hab. session 21.62.13.0-0.2-1.71.7-1.7-1.7-1.31.3-1.4
Locomotion velocity, hab. session 21.92.53.60.2-1.81.8-1.9-1.8-1.41.5-1.5
Novel to familiar place preference ratio1.41.52.00.01.2-1.21.31.21.4-1.31.4
Novelty place preference1.61.62.50.11.2-1.21.31.31.6-1.41.5
Time in novel zone, NPP test1.31.32.70.41.1-1.11.21.11.6-1.11.2
Total zone transitions, NPP test1.52.12.81.0-1.61.6-1.6-1.7-0.71.6-1.6
Total locomotion distance, NPP test3.34.56.00.7-2.42.4-2.3-2.4-1.92.1-2.1
Locomotion velocity, NPP test2.63.75.10.8-2.32.3-2.1-2.2-1.61.9-1.9
Intraocular pressure1.21.62.9-1.41.3-1.31.71.40.8-1.10.9
Delta distance traveled before/after self-admin0.50.50.80.8-0.80.8-0.4-0.4-0.70.9-0.9
Delta ambulatory time before/after self-admin0.20.20.30.5-0.60.6-0.4-0.4-0.40.5-0.5
Parametrial fat weight1.52.94.4-0.02.1-2.12.02.11.6-1.41.3
Pavlov. Cond. lever latency5.16.47.3-2.02.7-2.72.62.52.5-2.62.5
Pavlov. Cond. magazine entry latency0.20.21.41.20.0-0.00.20.20.2-0.20.2
Pavlov. Cond. change in total contacts1.51.63.21.8-1.11.1-1.0-0.9-1.41.3-1.2
Pavlov. Cond. index score2.53.14.42.1-1.91.9-1.8-1.7-1.51.7-1.6
Pavlov. Cond. latency score3.74.75.42.3-2.32.3-2.2-2.1-2.02.1-2.0
Pavlov. Cond. lever contacts4.04.75.51.7-2.42.4-2.2-2.1-2.22.2-2.2
Pavlov. Cond. magazine entry number0.30.31.5-1.20.5-0.50.40.30.4-0.40.3
Pavlov. Cond. intertrial magazine entries1.21.42.0-0.1-1.31.3-1.4-1.4-1.31.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.72.13.31.8-1.51.5-1.5-1.4-1.31.4-1.3
Pavlov. Cond. response bias0.60.81.31.2-0.90.9-0.7-0.6-0.90.8-0.8
Pavlov. Cond. lever latency0.10.10.30.5-0.30.3-0.3-0.30.30.3-0.4
Pavlov. Cond. magazine entry latency0.20.20.4-0.20.6-0.60.50.40.1-0.50.6
Pavlov. Cond. change in total contacts0.10.10.60.70.3-0.30.30.3-0.3-0.00.0
Pavlov. Cond. index score0.20.20.30.00.6-0.60.60.5-0.2-0.50.5
Pavlov. Cond. latency score0.10.10.1-0.10.3-0.30.30.3-0.3-0.20.3
Pavlov. Cond. lever contacts0.10.10.2-0.20.3-0.30.30.3-0.4-0.30.4
Pavlov. Cond. magazine entry number0.50.60.90.7-0.90.9-0.9-0.80.10.8-0.9
Pavlov. Cond. intertrial magazine entries0.30.41.71.3-0.30.3-0.6-0.60.20.6-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.00.6-0.60.60.5-0.2-0.50.6
Pavlov. Cond. response bias0.20.30.5-0.10.7-0.70.60.5-0.2-0.60.6
Time in closed arm before self-admin2.02.34.3-2.11.9-1.91.51.4-0.7-1.11.1
Time in closed arm after self-admin4.64.76.6-1.72.6-2.62.22.31.1-2.32.3
Time in open arm before self-admin4.34.76.62.0-2.62.6-2.3-2.2-1.32.1-2.1
Time in open arm after self-admin9.410.413.71.5-3.73.7-3.3-3.5-3.13.2-3.3
Bone: periosteal estimation0.61.23.6-1.90.9-0.91.11.0-0.2-1.11.1
Bone: periosteal perimeter0.71.22.0-1.41.1-1.11.31.2-0.2-1.01.0
Bone: post-yield work0.10.10.8-0.9-0.20.2-0.1-0.2-0.3-0.20.3
Progressive ratio test 1 active lever presses0.60.71.3-1.10.9-0.91.00.90.3-0.50.4
Progressive ratio test 1 breakpoint0.40.40.8-0.90.7-0.70.80.7-0.0-0.40.4
Progressive ratio test 1 inactive lever presses0.50.52.2-1.50.6-0.60.80.8-0.30.0-0.1
Progressive ratio test 2 active lever presses1.01.02.0-1.21.4-1.41.00.90.9-0.50.4
Progressive ratio test 2 breakpoint0.80.81.6-1.01.3-1.30.80.80.9-0.40.4
Progressive ratio test 2 inactive lever presses1.61.86.6-2.61.5-1.51.11.10.3-0.70.6
Incentive Sensitization - Responses2.32.33.6-1.11.9-1.91.31.31.8-1.31.3
Incentive Sensitization - Breakpoint2.02.03.2-0.81.8-1.81.21.21.8-1.21.3
Sum of active levers in priming session hrs 5-60.90.91.9-0.5-1.11.1-1.2-1.4-0.60.7-0.7
Progressive ratio0.20.20.4-0.60.5-0.50.30.3-0.1-0.60.6
Food seeking constrained by brief footshock0.20.21.0-1.0-0.40.4-0.3-0.3-0.5-0.30.3
Seeking ratio, punishment vs. effort0.50.61.0-0.1-1.01.0-0.7-0.8-0.80.7-0.6
Retroperitoneal fat weight0.20.71.31.01.1-1.11.00.9-0.1-0.50.4
Reaction time number correct2.63.74.70.8-1.91.9-2.1-2.2-2.02.1-2.1
Reaction time mean minus median0.81.03.82.0-0.70.7-0.9-0.90.10.9-1.0
Reaction time mean minus median AUC0.70.92.21.5-0.90.9-1.0-0.90.10.8-0.9
Reaction time num false alarms0.20.30.50.7-0.50.5-0.5-0.70.40.4-0.4
Reaction time num false alarms AUC0.20.30.80.9-0.40.4-0.4-0.60.50.4-0.4
Reaction time trials correct on left2.63.74.70.8-1.91.9-2.1-2.2-2.02.1-2.1
Reaction time trials on left2.84.05.10.9-2.02.0-2.2-2.3-2.02.2-2.1
Reaction time mean1.31.84.61.51.1-1.11.31.42.2-0.90.9
Reaction time mean AUC1.31.85.61.90.9-0.91.11.12.4-0.70.7
Median of all reaction times2.43.37.31.21.7-1.72.02.02.7-1.51.5
Reaction time omissions0.71.01.51.1-1.21.2-1.2-1.20.20.8-0.7
Reaction time false alarm rate0.20.31.00.20.4-0.40.40.31.0-0.50.4
Reaction time premature initiation rate3.64.85.71.7-2.42.4-2.3-2.2-2.42.0-2.1
Reaction time premature initiations5.78.09.02.2-3.03.0-3.0-2.9-2.92.8-2.8
Std. dev. reaction times0.71.05.32.3-0.60.6-0.6-0.60.40.7-0.8
Reaction time trials completed2.84.05.10.9-2.02.0-2.2-2.3-2.02.2-2.1
Reaction time trials AUC2.23.24.00.8-1.81.8-1.9-2.0-1.92.0-1.9
Run reversals in cocaine runway, females0.90.84.8-2.20.5-0.50.40.5-0.8-0.30.2
Run reversals in cocaine runway, males2.92.86.82.6-1.61.6-1.5-1.5-0.21.8-1.7
Latency to leave start box in cocaine runway0.70.71.5-0.10.6-0.60.70.61.1-1.21.2
Latency to leave start box in cocaine runway, F0.91.02.8-1.70.5-0.50.70.60.6-1.31.3
Latency to leave start box in cocaine runway, M2.32.24.61.21.4-1.41.41.42.1-1.21.3
Std. dev. time between licks in bursts0.40.50.7-0.60.7-0.70.70.7-0.5-0.70.8
Total sessions with >9 infusions0.70.82.1-1.40.9-0.91.11.10.4-0.10.1
Short access day 1 total inactive lever presses5.25.814.5-3.82.3-2.32.62.60.6-2.01.9
Short access day 10 total inactive lever presses1.41.54.32.1-1.01.0-1.1-1.0-0.31.3-1.2
Short access day 1 total infusions1.92.18.1-2.91.4-1.41.31.3-0.3-0.80.8
Short access day 10 total infusions2.32.56.6-2.61.6-1.61.51.40.4-1.51.4
Short access total infusions2.42.75.3-2.31.8-1.81.71.70.7-1.31.2
Short access day 1 locomotion3.43.67.9-2.82.0-2.02.01.90.3-1.61.6
Short access day 10 total locomotion0.80.94.2-2.10.7-0.70.70.7-1.1-0.30.2
Short access total locomotion1.71.73.5-1.91.4-1.41.51.5-0.2-0.90.9
One hour access (0.3 mA shock)2.63.14.8-2.21.8-1.81.81.81.3-1.61.5
Compulsive drug intake0.30.31.51.2-0.10.10.10.20.9-0.20.3
One hour access (shock baseline)2.83.39.8-3.11.9-1.91.71.70.5-1.31.3
Social response proportion0.50.52.7-0.2-0.30.3-0.6-0.4-1.60.5-0.6
Social responses1.52.04.40.6-1.41.4-1.6-1.6-2.11.0-1.1
Social time0.20.20.60.1-0.40.4-0.7-0.6-0.70.2-0.3
Soleus weight0.92.73.9-0.81.7-1.71.82.01.4-1.71.7
Bone: stiffness1.11.75.6-2.41.0-1.01.00.8-1.3-1.21.2
Tibialis anterior weight0.72.52.91.2-1.71.7-1.7-1.7-1.41.7-1.6
Time to tail flick, vehicle, before self-admin1.31.31.7-1.11.1-1.11.31.11.2-1.11.1
Time to tail flick, vehicle, after self-admin1.51.62.5-1.61.5-1.51.41.40.6-1.01.0
Time to tail flick, test, before self-admin0.70.72.6-1.60.6-0.60.70.6-0.6-0.70.7
Time to tail flick, test, after self-admin1.21.21.80.21.1-1.11.21.31.1-1.21.1
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.60.2-0.20.10.3-0.4-0.00.0
Delta time to tail flick, test, before/after SA0.40.30.90.30.5-0.50.50.61.0-0.50.5
Tibia length0.30.83.5-1.5-0.40.4-0.2-0.0-1.9-0.00.1
Ambulatory time before self-admin0.20.21.0-0.60.0-0.0-0.3-0.3-1.00.2-0.2
Ambulatory time after self-admin0.80.93.1-0.6-0.70.7-0.8-0.9-1.80.8-0.7
Bone: tissue strength0.00.00.10.30.2-0.20.0-0.00.3-0.00.1
Total heroin consumption0.20.20.30.3-0.40.4-0.4-0.50.20.6-0.5
Bone: trabecular number1.42.24.50.2-1.41.4-1.3-1.2-2.11.7-1.7
Bone: trabecular spacing0.70.91.5-0.10.9-0.90.90.81.2-1.11.2
Bone: trabecular thickness1.51.86.0-1.2-1.11.1-0.9-1.1-2.41.0-1.0
Bone: trabecular tissue density0.10.20.90.9-0.30.3-0.4-0.5-0.1-0.00.1
Water consumed over 24 hours1.31.62.70.0-1.31.3-1.5-1.5-1.71.0-0.9
Number of responses in last shaping day1.31.43.2-1.81.1-1.11.21.20.5-1.11.1