Hub : Genes

Map3k3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Map3k3 0.02 0.01 2.2e-03 0.02 0.01 0.01 0.01 2.7e-03 1.6e-02 4.6e-02 4.3e-02
2 PL intron excision ratio chr10_91577846_91580095 0.03 0.02 9.9e-03 0.01 0.01 0.01 0.01 9.6e-03 2.9e-02 2.1e-02 2.4e-02
3 NAcc mRNA stability Map3k3 0.03 0.02 1.5e-03 0 0 0.01 0 3.6e-01 5.2e-02 3.9e-02 2.9e-01
4 Brain mRNA stability Map3k3 0.05 0.03 3.1e-03 0.01 0.02 0.01 0.01 2.0e-02 5.5e-03 3.5e-02 1.8e-02
5 Adipose isoform ratio NM_001107058.3 0.13 0.06 3.1e-06 0.02 0.03 0.02 0.02 6.2e-03 6.9e-04 5.3e-03 2.8e-03
6 Adipose isoform ratio XM_063269201.1 0.13 0.06 5.0e-06 0.01 0.02 0.01 0.02 1.4e-02 1.4e-03 9.0e-03 5.0e-03
7 Adipose alternative TSS NM_001107058.3 0.15 0.07 3.6e-07 0.02 0.04 0.03 0.03 2.7e-03 2.6e-05 9.7e-05 3.7e-04
8 Adipose alternative TSS XM_063269201.1 0.16 0.07 5.1e-07 0.02 0.04 0.03 0.03 2.6e-03 2.8e-05 2.1e-04 3.3e-04
9 Adipose gene expression Map3k3 0.05 0.03 6.1e-03 0.02 0 0.01 0.01 4.4e-03 1.4e-01 4.4e-02 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.54.310.2-1.2-2.2-2.7-3.2-1.81.6-1.61.4-2.1
Area under the delay curve0.60.72.3-0.2-0.7-1.5-1.20.5-0.60.7-0.80.1
BMI with tail0.31.05.3-1.2-1.5-0.10.2-0.20.40.1-0.22.3
BMI without tail0.82.47.5-2.3-2.7-1.4-1.5-0.50.60.0-0.22.0
Body weight1.46.215.4-3.9-3.9-3.1-2.1-1.81.9-1.31.11.0
Weight adjusted by age0.61.01.31.01.10.61.01.1-1.11.1-1.10.4
Bone surface6.010.817.3-3.4-3.8-4.2-3.7-3.12.9-2.72.5-3.1
Bone volume5.08.915.9-2.9-3.6-4.0-3.8-2.62.5-2.32.1-2.6
Breakpoint value in progressive ratio session0.50.61.4-0.2-0.50.00.5-0.90.9-1.11.2-0.6
Number of licking bursts0.00.10.20.10.1-0.30.3-0.10.1-0.10.1-0.4
Context. condit. distance diff. score0.91.02.10.30.91.21.41.0-0.90.9-0.81.3
Locomotion velocity, session 11.92.05.3-1.4-1.3-2.3-1.8-1.21.1-1.00.9-1.3
Locomotion distance, session 10.60.72.6-0.4-0.2-1.6-1.40.4-0.50.6-0.7-0.5
Locomotion velocity, session 21.01.12.2-0.9-0.5-1.0-0.4-1.11.0-1.31.4-1.5
Locomotion distance, session 20.20.30.4-0.40.6-0.6-0.20.6-0.60.5-0.5-0.4
Locomotion velocity, session 30.20.20.60.30.3-0.20.1-0.40.5-0.50.5-0.8
Locomotion distance, session 30.40.41.3-0.3-0.1-0.4-0.1-0.70.7-0.80.8-1.1
Stereotopy head waving bouts, day 30.20.20.80.7-0.1-0.5-0.9-0.20.1-0.10.1-0.5
Stereotopy head waving duration, day 30.40.40.80.90.3-0.2-0.20.8-0.80.8-0.80.4
Locomotion velocity, session 70.10.10.30.40.50.40.1-0.00.0-0.10.1-0.4
Locomotion distance, session 70.60.81.80.30.60.10.11.3-1.31.3-1.30.3
Stereotopy head waving bouts, day 70.20.31.10.50.50.0-0.0-0.40.4-0.50.6-1.0
Stereotopy head waving duration, day 70.40.51.41.01.20.60.6-0.10.0-0.40.5-0.8
Locomotion velocity, session 80.30.41.2-0.90.00.31.1-0.40.5-0.50.60.7
Locomotion distance, session 80.50.81.4-0.30.80.20.71.2-1.21.0-1.01.0
Degree of sensitization distance1.71.83.7-0.10.3-0.1-0.11.8-1.81.9-1.91.4
Degree of sensitization stereotypy0.50.51.20.61.10.80.7-0.30.3-0.50.6-1.0
Conditioned locomotion0.50.61.2-0.3-0.4-0.6-0.40.9-1.00.9-0.91.1
Cocaine response after cond. corrected0.20.21.50.50.4-0.10.30.00.00.2-0.2-1.2
Cocaine response after cond. not corrected1.21.46.60.30.3-0.30.4-1.21.2-1.11.1-2.6
Cocaine response before conditioning1.41.63.2-0.5-0.2-0.5-0.3-1.61.5-1.71.8-1.8
Saline control response0.40.52.3-0.8-0.90.40.4-0.10.1-0.20.21.5
Bone: connectivity density2.74.39.8-1.7-2.3-2.7-3.1-1.61.4-1.41.3-2.1
Bone: cortical apparent density1.92.75.32.31.90.5-0.11.9-2.01.9-1.90.6
Bone: cortical area2.53.85.0-1.3-2.1-2.2-2.0-2.12.1-1.81.7-2.1
Bone: cortical porosity15.416.628.1-3.0-3.3-1.9-1.1-5.35.3-5.25.1-4.0
Bone: cortical porosity11.312.220.8-2.8-3.1-1.9-1.1-4.54.6-4.34.3-3.2
Bone: cortical thickness0.91.67.72.81.30.4-0.3-0.50.5-0.30.3-1.9
Bone: cortical thickness1.01.24.02.01.01.20.0-0.60.6-0.60.7-1.7
Bone: cortical tissue density1.82.55.32.31.80.6-0.11.8-1.91.8-1.70.6
Condit. Reinf. active minus inactive responses1.51.73.7-1.6-1.9-1.4-1.0-1.21.2-1.21.2-0.6
Condit. Reinf. active-inactive response ratio0.80.81.4-1.1-1.2-0.6-0.4-1.00.9-1.01.0-0.6
Condit. Reinf. active responses1.51.94.5-2.0-2.1-1.9-1.4-0.90.8-0.80.8-0.2
Condit. Reinf. inactive responses0.91.13.8-1.2-1.2-2.0-1.50.3-0.40.4-0.50.4
Incentive salience index mean2.63.24.2-2.0-2.1-1.8-1.5-1.91.8-1.91.9-1.2
Condit. Reinf. lever presses1.42.03.2-1.3-1.0-1.0-1.0-1.61.6-1.81.8-1.2
Condit. Reinf. active minus inactive responses4.86.211.3-3.1-3.2-3.4-2.8-1.91.8-1.81.6-2.1
Condit. Reinf. active-inactive response ratio4.35.06.3-2.3-2.5-2.3-2.1-2.32.1-2.22.1-2.3
Condit. Reinf. active responses3.95.411.3-3.3-3.4-3.2-2.8-1.51.3-1.31.2-1.1
Condit. Reinf. inactive responses0.91.22.3-1.4-1.5-1.5-1.40.5-0.60.6-0.71.0
Condit. Reinf. lever presses1.62.33.8-2.0-1.8-1.2-1.3-1.61.5-1.61.5-1.0
Condit. Reinf. lever reinforcers received3.75.210.4-3.1-3.2-3.1-2.8-1.51.4-1.41.2-1.2
Conditioned reinforcement - actives0.20.41.9-1.0-0.3-0.2-0.20.2-0.10.3-0.31.4
Conditioned reinforcement - inactives0.60.91.8-1.3-1.0-0.5-0.6-1.21.2-1.00.9-0.0
Conditioned locomotion1.41.95.3-2.3-1.7-0.9-1.4-1.31.3-1.11.00.4
Patch foraging indifference point 0 sec1.62.96.8-2.4-2.5-2.5-2.60.3-0.40.5-0.70.7
Patch foraging indifference point AUC0.30.51.6-1.3-0.7-0.8-0.50.1-0.10.2-0.21.0
Delay disc. indifference point, 0s delay0.80.81.51.00.3-0.7-0.31.2-1.21.2-1.20.4
Delay disc. indifference point, 16s delay0.50.62.3-0.3-1.1-1.5-1.10.1-0.10.4-0.50.2
Delay disc. indifference point, 2s delay1.71.95.9-0.9-1.2-2.4-2.30.7-0.91.0-1.1-0.1
Delay disc. indifference point, 24s delay1.01.23.2-1.2-1.4-1.8-1.50.2-0.20.5-0.71.0
Delay disc. indifference point, 4s delay0.30.31.60.60.3-0.4-0.1-0.20.2-0.10.1-1.3
Delay disc. indifference point, 8s delay0.60.82.30.1-0.5-1.5-1.40.6-0.70.8-0.9-0.1
Indifference point function ln k0.20.31.40.8-0.1-0.7-0.7-0.20.1-0.10.1-1.2
Indifference point function log k0.20.31.40.8-0.1-0.7-0.7-0.20.1-0.10.1-1.2
Patch foraging total patch changes 0 sec1.73.27.6-2.5-2.7-2.8-2.70.1-0.20.4-0.50.5
Patch foraging total patch changes 12 sec1.92.46.8-2.6-1.8-1.8-1.80.8-0.90.8-0.91.6
Patch foraging total patch changes 18 sec0.61.03.0-1.7-1.7-1.0-1.0-0.40.4-0.30.20.3
Patch foraging total patch changes 24 sec1.72.96.9-2.4-2.5-2.6-2.6-0.40.2-0.1-0.10.2
Patch foraging total patch changes 6 sec1.11.74.0-2.0-2.0-1.8-1.7-0.70.6-0.50.40.0
Patch foraging time to switch 0 sec0.40.71.91.00.71.40.9-0.60.6-0.80.8-0.7
Patch foraging water rate 0 sec0.81.74.3-1.8-2.0-2.1-1.9-0.40.4-0.1-0.00.2
Patch foraging water rate 12 sec0.20.42.60.90.3-0.30.1-0.40.4-0.20.2-1.6
Patch foraging water rate 18 sec0.50.82.8-0.3-0.5-1.3-1.3-0.40.3-0.30.3-1.7
Patch foraging water rate 24 sec0.10.10.7-0.20.2-0.3-0.00.2-0.20.2-0.2-0.8
Patch foraging water rate 6 sec0.60.92.7-0.2-0.9-1.7-1.6-0.60.5-0.40.3-1.1
Seeking ratio, delayed vs. immediate footshock0.30.41.50.20.21.20.90.2-0.10.2-0.21.0
Distance traveled before self-admin0.50.62.70.80.4-0.10.8-0.60.7-0.60.6-1.6
Distance traveled after self-admin0.20.31.20.10.20.31.1-0.20.2-0.30.3-0.8
Extensor digitorum longus weight3.312.823.33.72.94.23.83.3-2.93.2-3.04.8
Bone: elastic displacement0.70.81.51.20.80.70.4-0.90.9-0.90.9-1.2
Bone: elastic work1.62.14.2-0.3-0.7-0.4-0.9-2.02.0-1.91.8-1.4
Bone: endosteal estimation7.416.239.5-6.3-5.4-4.3-3.2-3.63.5-3.33.1-1.8
Bone: endosteal perimeter7.616.241.4-6.4-5.7-4.5-3.0-3.53.4-3.12.9-1.3
Epididymis fat weight0.10.50.9-0.9-0.9-0.8-0.70.3-0.30.5-0.50.9
Delta time in closed arm before/after self-admin0.30.31.6-0.00.2-0.4-0.2-0.50.5-0.50.5-1.2
Delta time in open arm before/after self-admin2.32.36.70.60.40.70.31.9-1.81.8-1.72.6
Diff in mean of infusions in LGA sessions1.11.43.51.91.61.41.50.8-0.70.6-0.50.7
Delay discount exponential model param0.60.72.30.40.81.51.3-0.40.5-0.70.8-0.2
Extinction: sum of active levers before priming0.70.71.60.30.1-0.20.51.2-1.11.0-1.01.3
Active lever presses in extinction session 60.80.82.3-0.9-1.5-0.8-0.4-0.90.9-0.90.9-0.3
Bone: final force1.72.75.2-1.2-1.4-2.1-1.7-1.61.6-1.31.3-2.3
Bone: final moment2.13.36.3-1.2-1.5-2.1-1.8-1.91.8-1.61.5-2.5
Food consumed during 24 hour testing period0.81.14.0-2.0-1.5-1.1-0.7-0.10.2-0.0-0.01.5
Glucose0.71.13.41.41.51.21.80.4-0.30.4-0.3-0.1
Heart weight0.20.30.90.3-0.0-0.6-0.10.5-0.50.9-0.90.1
Delay discount hyperbolic model param0.60.72.50.50.81.61.4-0.40.4-0.60.7-0.1
Intermittent access intake day 1-15 change0.30.73.00.10.71.71.5-0.30.4-0.40.40.1
Intermittent access intake escalation0.20.51.9-0.40.21.41.2-0.40.5-0.50.50.1
Intermittent access intake escalation 20.50.61.7-0.5-0.01.31.0-0.70.8-0.70.80.0
Intermitt. access day 1 inactive lever presses0.72.74.7-2.1-2.2-1.3-1.7-1.61.6-1.61.5-0.8
Intermitt. access day 15 inactive lever presses0.81.72.7-1.0-1.6-0.5-1.6-1.51.5-1.41.3-0.5
Intermitt. access escalation Index1.21.73.71.91.71.31.91.0-0.90.9-0.8-0.3
Intermittent access day 1 total infusions0.40.62.1-1.4-0.8-1.1-0.9-0.40.4-0.30.30.0
Intermittent access day 15 total infusions0.40.62.9-1.7-0.8-0.1-0.0-0.20.3-0.00.01.3
Intermittent access terminal intake (last 3 days)0.71.05.0-2.2-1.1-0.4-0.6-0.40.5-0.30.21.2
Intermittent access total infusions0.91.15.7-2.4-1.1-0.8-0.9-0.20.20.0-0.11.2
Intermittent access day 1 locomotion2.63.46.9-2.6-2.2-1.7-1.6-1.91.9-1.71.6-0.1
Intermittent access day 15 total locomotion1.32.410.4-3.2-2.1-0.9-1.1-1.11.1-0.90.81.1
Intermittent access total locomotion3.54.214.3-3.8-2.6-1.7-2.0-1.71.7-1.51.30.5
Intermittent access standard deviation0.30.61.7-1.3-0.60.4-0.4-0.80.8-0.80.80.4
Left kidney weight0.10.41.7-0.0-0.1-1.1-0.8-0.20.2-0.0-0.0-1.3
Right kidney weight0.20.82.1-0.9-0.5-1.4-1.1-0.70.7-0.50.4-1.2
Cocaine induced anxiety0.40.51.90.20.1-0.5-0.3-0.80.8-0.80.7-1.4
Post-drug Anxiety0.30.31.30.30.3-0.1-0.1-0.70.7-0.60.5-1.1
Baseline Anxiety0.10.10.50.50.20.70.40.1-0.00.1-0.10.5
Tail length2.18.314.5-3.8-3.5-3.4-3.4-2.62.5-2.32.1-1.4
Length with tail1.46.014.4-3.8-3.0-3.5-2.6-1.91.8-1.61.4-0.6
Length without tail0.10.41.6-1.2-0.6-1.2-0.5-0.30.3-0.10.10.2
Times rat made contact with spout0.60.71.7-1.3-1.0-0.6-0.5-0.90.9-0.90.8-0.2
Lifetime Intake1.01.25.3-2.3-1.4-1.0-1.2-0.40.4-0.20.11.0
Liver weight, left4.27.012.5-3.5-2.7-2.4-1.7-2.82.7-2.82.7-2.1
Liver weight, right0.61.15.70.50.2-0.5-1.0-0.90.8-0.70.6-2.4
Locomotor activity0.10.21.8-1.3-0.1-0.00.0-0.20.2-0.30.30.2
Locomotor testing distance0.30.52.2-1.5-0.5-0.00.0-0.70.7-0.80.80.2
Locomotor testing rearing0.61.11.9-1.4-0.21.11.0-1.11.1-1.31.30.3
Locomotion in novel chamber1.01.33.5-0.90.4-0.30.4-1.31.4-1.31.3-1.9
Locomotion in novel chamber post-restriction0.71.25.0-1.2-1.5-2.2-1.40.0-0.10.3-0.40.0
Fecal boli incidents, locomotor time 10.10.10.40.30.1-0.60.60.3-0.30.4-0.30.3
Change in fecal boli incidents, locomotor task0.40.40.90.20.10.4-0.50.7-0.70.9-0.90.8
Time >=10cm from walls, locomotor time 11.61.74.51.41.92.12.10.5-0.40.4-0.2-0.5
Bouts of movement, locomotor time 10.10.10.50.70.1-0.3-0.10.2-0.20.3-0.20.4
Total resting periods, locomotor time 10.10.10.50.70.1-0.4-0.30.2-0.20.2-0.30.3
Rest time, locomotor task time 10.10.10.50.70.0-0.5-0.50.2-0.30.2-0.2-0.2
Distance moved, locomotor task time 10.20.30.8-0.9-0.60.3-0.2-0.70.7-0.60.60.0
Vertical activity count, locomotor time 10.20.50.9-0.9-0.60.0-0.4-0.90.9-0.80.8-0.8
Time >=10cm from walls, locomotor time 21.11.72.60.10.61.40.9-1.51.5-1.61.6-1.6
Bouts of movement, locomotor time 20.20.31.71.30.10.60.40.3-0.20.3-0.20.4
Total resting periods, locomotor time 20.20.42.31.50.30.60.60.4-0.40.4-0.30.3
Rest time, locomotor task time 22.12.78.12.81.30.21.31.8-1.81.8-1.70.6
Distance moved, locomotor task time 21.92.34.3-1.2-0.60.7-0.3-2.02.0-2.12.1-1.2
Vertical activity count, locomotor time 22.43.35.5-1.8-1.5-0.4-1.2-2.32.3-2.32.3-1.1
Light reinforcement 10.71.73.10.1-1.1-1.4-1.81.3-1.41.4-1.51.3
Light reinforcement 20.91.55.6-0.2-1.3-1.8-2.40.6-0.70.8-0.90.4
Bone: marrow area7.315.938.5-6.2-5.3-4.2-3.1-3.63.5-3.43.2-1.8
Bone: maximum diameter3.87.011.8-3.1-3.4-3.4-2.6-2.52.4-2.11.9-2.0
Bone: maximum force1.62.97.5-1.6-1.9-2.7-2.3-1.21.1-0.70.6-1.7
Bone: maximum moment2.03.47.7-1.7-2.0-2.8-2.4-1.51.5-1.10.9-1.9
Mean time between licks in bursts0.10.30.9-0.4-0.1-0.20.10.5-0.40.7-0.80.9
Mean num. licks in bursts0.10.20.6-0.6-0.7-0.1-0.6-0.10.1-0.0-0.00.7
Cd content in liver3.84.26.12.02.42.52.32.0-1.91.7-1.61.9
Co content in liver1.61.84.71.31.72.22.00.7-0.60.4-0.31.5
Cu content in liver0.30.30.9-0.4-0.9-0.3-0.8-0.60.6-0.60.60.1
Fe content in liver0.20.20.5-0.20.30.10.2-0.40.4-0.60.7-0.7
K content in liver0.30.31.1-0.8-0.4-1.0-0.80.4-0.40.3-0.30.0
Mg content in liver0.80.81.70.60.70.2-0.41.2-1.31.0-1.00.9
Mn content in liver0.60.62.50.00.0-1.3-1.60.4-0.60.3-0.3-0.9
Na content in liver0.20.30.5-0.7-0.5-0.5-0.2-0.40.4-0.70.7-0.0
Rb content in liver1.51.74.32.02.11.31.01.2-1.20.9-0.8-0.2
Se content in liver1.41.62.81.21.00.30.61.7-1.71.6-1.61.1
Sr content in liver0.90.81.4-0.8-1.1-0.5-0.5-1.11.2-1.01.0-0.4
Zn content in liver0.10.20.40.60.50.20.20.4-0.40.4-0.4-0.2
Bone: minimum diameter7.814.228.7-5.4-5.2-4.6-3.4-3.43.3-2.92.7-1.3
Time in familiar zone, hab. session 10.70.62.0-0.5-0.10.10.50.9-0.90.9-0.91.4
Time in novel zone, hab. session 10.70.72.11.20.30.3-0.0-0.80.8-0.80.8-1.4
Total zone transitions, hab. session 10.10.10.5-0.70.2-0.4-0.20.2-0.20.3-0.40.3
Total locomotion distance, hab. session 11.01.43.5-1.4-1.0-1.4-1.9-1.00.9-0.80.7-1.1
Locomotion velocity, hab. session 11.01.53.7-1.8-1.1-1.6-1.9-0.80.7-0.60.5-0.8
Time in familiar zone, hab. session 20.40.41.4-1.2-0.10.31.00.2-0.20.1-0.01.2
Time in novel zone, hab. session 20.70.72.51.2-0.1-0.6-1.5-0.30.2-0.0-0.0-1.6
Total zone transitions, hab. session 20.30.30.5-0.50.6-0.40.20.7-0.70.6-0.60.7
Total locomotion distance, hab. session 20.70.92.0-0.8-0.2-1.2-1.40.9-1.01.0-1.00.8
Locomotion velocity, hab. session 20.91.12.0-0.8-0.1-1.3-1.41.1-1.11.1-1.20.8
Novel to familiar place preference ratio0.60.61.1-0.6-1.1-1.0-0.6-0.90.9-0.70.7-0.3
Novelty place preference0.40.40.6-0.3-0.8-0.7-0.4-0.80.8-0.70.7-0.4
Time in novel zone, NPP test0.50.50.9-0.3-0.7-0.6-0.3-0.90.9-0.80.8-0.6
Total zone transitions, NPP test0.60.91.6-0.50.4-1.3-1.01.1-1.21.2-1.20.2
Total locomotion distance, NPP test0.81.14.3-1.3-0.6-1.7-2.10.1-0.30.3-0.4-0.5
Locomotion velocity, NPP test0.91.33.5-0.9-0.4-1.6-1.90.9-1.01.1-1.20.3
Intraocular pressure0.40.51.7-0.3-0.9-0.7-0.40.4-0.30.7-0.81.3
Delta distance traveled before/after self-admin0.10.10.40.10.00.50.70.4-0.30.2-0.20.5
Delta ambulatory time before/after self-admin0.10.20.4-0.4-0.2-0.00.10.5-0.50.4-0.40.7
Parametrial fat weight0.92.04.7-1.1-1.4-2.2-1.9-1.21.1-1.00.9-1.5
Pavlov. Cond. lever latency3.64.66.92.01.71.61.32.6-2.62.6-2.61.7
Pavlov. Cond. magazine entry latency4.45.77.1-2.5-2.7-2.3-2.1-2.62.5-2.62.5-1.4
Pavlov. Cond. change in total contacts4.85.17.9-1.9-2.2-1.7-1.6-2.72.7-2.82.8-1.3
Pavlov. Cond. index score4.35.46.9-2.3-2.4-2.2-1.8-2.62.6-2.62.6-1.5
Pavlov. Cond. latency score3.64.56.2-2.2-2.1-1.9-1.4-2.42.4-2.52.5-1.3
Pavlov. Cond. lever contacts4.55.48.5-2.1-1.9-1.6-1.3-2.92.9-2.92.9-1.6
Pavlov. Cond. magazine entry number3.44.35.32.12.32.11.92.2-2.12.3-2.21.2
Pavlov. Cond. intertrial magazine entries1.92.34.3-0.6-0.6-1.1-0.61.8-1.82.0-2.12.0
Pavlov. Cond. lever-magazine prob. diff.4.85.97.6-2.2-2.5-2.3-1.9-2.82.7-2.82.7-1.7
Pavlov. Cond. response bias7.49.211.1-2.9-3.1-2.9-2.9-3.33.2-3.33.2-2.4
Pavlov. Cond. lever latency0.20.31.01.00.70.60.40.4-0.40.4-0.40.5
Pavlov. Cond. magazine entry latency1.51.84.21.52.01.62.00.9-0.90.8-0.70.1
Pavlov. Cond. change in total contacts0.10.21.1-1.0-0.3-0.20.20.3-0.30.1-0.10.6
Pavlov. Cond. index score0.10.10.4-0.30.20.10.6-0.20.2-0.30.3-0.4
Pavlov. Cond. latency score0.20.20.6-0.20.40.20.8-0.40.4-0.50.5-0.7
Pavlov. Cond. lever contacts0.10.20.6-0.8-0.5-0.4-0.4-0.20.1-0.20.2-0.2
Pavlov. Cond. magazine entry number1.61.95.4-1.6-2.3-1.7-2.0-0.90.9-0.70.60.4
Pavlov. Cond. intertrial magazine entries5.78.521.8-4.0-4.7-3.4-3.6-2.12.1-1.81.50.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.20.40.20.7-0.10.0-0.10.2-0.4
Pavlov. Cond. response bias0.00.00.1-0.30.1-0.10.10.2-0.30.2-0.2-0.1
Time in closed arm before self-admin0.60.81.40.1-0.31.00.4-1.01.1-1.11.2-0.7
Time in closed arm after self-admin0.60.61.10.30.51.11.0-0.70.7-0.80.8-0.8
Time in open arm before self-admin0.60.62.20.71.00.10.9-0.50.5-0.40.4-1.5
Time in open arm after self-admin0.70.82.10.00.2-0.10.31.1-1.01.2-1.21.5
Bone: periosteal estimation7.114.923.8-4.9-4.9-4.4-3.6-3.73.6-3.33.1-2.6
Bone: periosteal perimeter4.98.411.9-3.5-3.4-2.9-2.0-3.23.1-2.82.7-2.3
Bone: post-yield work1.01.53.0-1.7-1.4-1.3-0.5-1.31.3-1.11.0-0.9
Progressive ratio test 1 active lever presses1.41.74.1-2.0-1.8-1.7-1.7-0.80.8-0.60.50.2
Progressive ratio test 1 breakpoint1.61.94.5-2.1-2.0-1.8-1.9-0.80.8-0.60.50.3
Progressive ratio test 1 inactive lever presses1.31.94.9-2.2-1.9-1.8-1.6-1.00.9-0.80.70.1
Progressive ratio test 2 active lever presses2.53.08.2-2.9-2.5-2.3-2.1-1.00.9-0.60.50.4
Progressive ratio test 2 breakpoint2.73.18.9-3.0-2.6-2.3-2.0-1.01.0-0.70.50.4
Progressive ratio test 2 inactive lever presses1.01.73.8-1.9-1.9-1.6-1.9-0.30.30.0-0.21.1
Incentive Sensitization - Responses1.21.75.2-2.3-1.9-1.9-1.2-0.70.7-0.50.30.2
Incentive Sensitization - Breakpoint1.21.65.5-2.3-1.8-1.8-1.1-0.70.7-0.50.40.2
Sum of active levers in priming session hrs 5-61.51.42.21.51.11.01.51.2-1.11.0-0.91.1
Progressive ratio0.20.30.9-0.1-0.6-0.9-0.10.5-0.50.6-0.60.4
Food seeking constrained by brief footshock1.01.24.6-2.2-1.2-0.50.1-0.91.0-1.01.00.8
Seeking ratio, punishment vs. effort0.60.82.0-1.4-0.60.1-0.2-1.11.1-1.11.1-0.0
Retroperitoneal fat weight0.31.33.0-1.7-1.6-1.6-1.7-0.60.6-0.40.30.1
Reaction time number correct0.40.71.70.60.4-0.6-0.31.0-1.11.3-1.3-0.3
Reaction time mean minus median0.10.20.70.80.50.70.4-0.10.1-0.10.1-0.1
Reaction time mean minus median AUC0.30.82.21.51.20.70.50.8-0.80.8-0.7-0.0
Reaction time num false alarms1.62.35.6-2.4-2.1-1.7-1.1-1.31.3-1.21.1-0.5
Reaction time num false alarms AUC1.82.96.7-2.6-2.4-2.0-1.6-1.41.4-1.21.2-0.6
Reaction time trials correct on left0.40.71.70.60.4-0.6-0.31.0-1.11.3-1.3-0.3
Reaction time trials on left0.40.71.70.60.3-0.7-0.41.0-1.11.3-1.3-0.3
Reaction time mean0.30.51.81.31.10.80.30.2-0.30.1-0.1-1.0
Reaction time mean AUC0.50.82.71.61.41.10.60.3-0.30.00.0-1.0
Median of all reaction times0.40.61.71.31.10.70.20.3-0.40.1-0.1-1.1
Reaction time omissions0.50.73.00.0-0.9-1.0-1.7-0.50.4-0.30.1-1.1
Reaction time false alarm rate2.23.05.8-2.4-2.1-1.2-1.0-1.91.9-1.91.8-0.6
Reaction time premature initiation rate0.50.72.2-0.8-1.5-1.2-1.1-0.30.3-0.20.10.8
Reaction time premature initiations0.40.82.1-0.5-1.2-1.4-1.20.3-0.30.6-0.70.9
Std. dev. reaction times0.10.20.80.90.70.60.10.0-0.1-0.00.1-0.5
Reaction time trials completed0.40.71.70.60.3-0.7-0.41.0-1.11.3-1.3-0.3
Reaction time trials AUC0.40.82.00.60.4-0.6-0.31.1-1.21.4-1.4-0.2
Run reversals in cocaine runway, females0.40.40.80.80.30.90.1-0.80.9-0.60.6-0.3
Run reversals in cocaine runway, males0.20.20.90.4-0.0-0.10.3-0.50.5-0.40.3-0.9
Latency to leave start box in cocaine runway0.20.21.00.60.51.00.4-0.10.1-0.10.1-0.4
Latency to leave start box in cocaine runway, F0.70.82.50.90.50.40.8-0.91.0-0.90.9-1.6
Latency to leave start box in cocaine runway, M0.40.41.4-0.20.21.20.00.6-0.60.5-0.51.0
Std. dev. time between licks in bursts0.10.20.50.10.30.20.10.4-0.40.4-0.40.7
Total sessions with >9 infusions0.10.10.9-0.4-0.10.2-0.10.1-0.00.2-0.21.0
Short access day 1 total inactive lever presses2.02.73.6-1.8-1.8-1.5-1.6-1.91.9-1.61.5-0.9
Short access day 10 total inactive lever presses0.10.10.70.2-0.5-0.3-0.80.1-0.10.2-0.20.2
Short access day 1 total infusions0.10.10.3-0.3-0.50.1-0.60.1-0.10.2-0.20.5
Short access day 10 total infusions0.81.03.5-1.9-1.4-0.5-1.0-0.80.8-0.70.60.4
Short access total infusions0.50.61.3-1.1-1.1-0.6-0.9-0.70.6-0.50.50.1
Short access day 1 locomotion0.60.81.9-1.1-1.4-0.9-1.2-0.60.7-0.30.20.8
Short access day 10 total locomotion2.13.98.5-2.9-2.7-1.1-1.5-2.02.1-2.01.90.5
Short access total locomotion1.41.73.3-1.8-1.8-0.5-1.1-1.51.5-1.31.20.5
One hour access (0.3 mA shock)0.30.41.1-1.1-0.8-0.6-0.1-0.60.6-0.50.5-0.2
Compulsive drug intake0.30.31.90.70.4-0.40.4-0.20.2-0.20.2-1.4
One hour access (shock baseline)0.30.42.2-1.5-0.7-0.2-0.5-0.10.1-0.00.00.9
Social response proportion0.20.31.10.40.50.71.10.2-0.10.3-0.30.3
Social responses0.10.10.3-0.50.20.30.50.00.00.00.00.4
Social time0.30.40.80.1-0.10.60.8-0.80.9-0.70.7-0.4
Soleus weight0.20.61.3-0.4-0.70.10.2-1.11.1-1.01.0-0.4
Bone: stiffness0.50.83.2-1.2-0.6-1.8-0.90.4-0.50.6-0.6-0.5
Tibialis anterior weight0.51.69.00.50.01.61.40.5-0.30.4-0.43.0
Time to tail flick, vehicle, before self-admin0.80.84.1-0.10.5-0.8-0.5-0.80.7-0.60.6-2.0
Time to tail flick, vehicle, after self-admin0.50.61.90.0-0.4-1.4-0.90.6-0.70.8-0.90.0
Time to tail flick, test, before self-admin0.50.51.30.40.61.11.1-0.50.5-0.70.7-0.4
Time to tail flick, test, after self-admin0.00.00.10.1-0.2-0.1-0.30.1-0.20.1-0.1-0.0
Delta time to tail flick, vehicle, before/after SA0.60.62.1-0.6-1.5-0.7-0.90.2-0.30.3-0.31.1
Delta time to tail flick, test, before/after SA0.40.40.7-0.1-0.1-0.6-0.70.8-0.80.8-0.80.2
Tibia length0.20.51.7-0.8-0.3-1.0-1.1-0.30.3-0.0-0.0-1.3
Ambulatory time before self-admin0.40.62.60.3-0.0-0.30.6-0.80.8-0.80.8-1.6
Ambulatory time after self-admin0.20.31.0-0.0-0.4-0.20.5-0.50.5-0.60.6-1.0
Bone: tissue strength0.90.91.80.81.30.00.41.2-1.21.2-1.2-0.1
Total heroin consumption0.91.12.5-1.0-0.5-1.0-0.3-1.11.0-1.21.2-1.6
Bone: trabecular number3.25.212.4-1.8-2.6-3.3-3.5-1.71.5-1.41.3-2.2
Bone: trabecular spacing1.92.56.50.61.72.22.51.3-1.11.0-0.91.8
Bone: trabecular thickness5.16.412.2-1.6-3.1-3.2-3.5-2.42.2-1.91.8-2.2
Bone: trabecular tissue density1.01.52.80.80.5-1.5-1.21.3-1.41.6-1.7-0.7
Water consumed over 24 hours0.20.20.4-0.5-0.5-0.5-0.6-0.50.5-0.40.4-0.3
Number of responses in last shaping day0.80.91.7-0.3-0.4-0.3-0.5-1.31.3-1.11.1-1.2