Hub : Genes

Map2k2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr7_8595481_8595594 0.02 0.02 9.3e-03 0.01 0.01 0 0 6.1e-02 6.6e-02 2.2e-01 8.7e-02
2 BLA alternative TSS XM_039079809.1 0.06 0.05 2.1e-03 0.03 0.04 0.02 0.03 1.2e-02 4.6e-03 2.3e-02 7.4e-03
3 BLA alternative TSS NM_133283.2 0.05 0.04 2.9e-03 0.03 0.03 0.02 0.03 1.5e-02 6.2e-03 2.5e-02 1.0e-02
4 NAcc gene expression Map2k2 0.06 0.04 1.8e-08 0.05 0.07 0.06 0.06 1.4e-06 4.2e-08 7.3e-08 5.0e-08
5 Eye isoform ratio XM_006240987.3 0.35 0.21 2.1e-04 0.24 0.29 0.27 0.28 1.3e-04 2.0e-05 4.3e-05 2.9e-05
6 Eye isoform ratio XM_039079809.1 0.32 0.18 7.7e-05 0.28 0.32 0.33 0.32 3.3e-05 6.4e-06 4.6e-06 7.5e-06
7 PL gene expression Map2k2 0.14 0.08 0.0e+00 0.21 0.21 0.21 0.21 4.0e-23 7.0e-23 7.6e-23 9.4e-23
8 NAcc isoform ratio XM_039079809.1 0.03 0.02 1.8e-04 0.03 0.03 0.02 0.03 9.5e-05 2.0e-04 9.5e-04 1.7e-04
9 Brain isoform ratio XM_039079809.1 0.06 0.05 1.7e-04 0.04 0.04 0.04 0.04 1.8e-04 2.5e-04 3.3e-04 2.5e-04
10 BLA gene expression Map2k2 0.21 0.12 8.5e-14 0.25 0.24 0.25 0.24 1.2e-13 4.0e-13 2.1e-13 6.1e-13
11 pVTA gene expression Map2k2 0.18 0.1 1.1e-08 0.19 0.18 0.18 0.18 9.5e-09 2.3e-08 2.5e-08 3.3e-08
12 OFC gene expression Map2k2 0.25 0.16 7.8e-05 0.18 0.2 0.2 0.19 4.3e-05 2.1e-05 1.3e-05 3.1e-05
13 Brain gene expression Map2k2 0.1 0.07 2.2e-08 0.06 0.07 0.06 0.06 1.2e-06 1.0e-06 2.1e-06 3.8e-06
14 LHb gene expression Map2k2 0.16 0.12 5.8e-03 0 0.04 0.04 0.03 3.0e-01 3.3e-02 3.5e-02 7.9e-02
15 Eye gene expression Map2k2 0.97 0.02 9.1e-04 0.04 0.09 0.17 0.16 9.9e-02 1.6e-02 1.2e-03 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.50.92.9-1.10.4-0.40.0-0.1-0.30.6-0.6-0.60.60.61.4-1.5-1.71.6
Area under the delay curve2.32.52.81.2-1.41.5-1.6-1.6-1.61.6-1.6-1.61.61.61.6-1.7-1.61.6
BMI with tail6.119.622.94.6-4.84.8-4.8-4.8-4.74.6-4.6-4.64.64.53.9-3.7-3.53.8
BMI without tail1.94.07.22.7-2.42.4-2.2-2.2-2.22.0-2.0-2.02.01.91.4-1.2-1.11.7
Body weight1.04.35.22.2-2.32.3-2.3-2.3-2.22.2-2.2-2.22.22.21.8-1.7-1.61.5
Weight adjusted by age0.20.21.21.1-0.70.7-0.6-0.5-0.50.3-0.3-0.30.40.3-0.00.10.20.2
Bone surface0.81.54.7-2.21.2-1.10.60.50.20.3-0.3-0.30.30.31.6-1.7-2.02.0
Bone volume0.91.54.7-2.21.2-1.10.60.50.20.3-0.3-0.30.30.31.6-1.7-2.01.9
Breakpoint value in progressive ratio session5.86.37.1-2.02.4-2.42.52.62.6-2.72.72.7-2.6-2.6-2.52.62.5-2.3
Number of licking bursts0.10.20.70.6-0.40.4-0.2-0.1-0.0-0.00.00.0-0.2-0.2-0.50.60.7-0.8
Context. condit. distance diff. score0.20.30.40.6-0.60.6-0.6-0.6-0.60.6-0.6-0.60.50.50.5-0.4-0.40.3
Locomotion velocity, session 10.40.41.6-1.31.0-1.00.80.80.6-0.60.60.6-0.5-0.5-0.0-0.1-0.20.4
Locomotion distance, session 10.20.31.0-0.90.5-0.50.30.20.10.1-0.1-0.10.10.10.7-0.8-0.91.0
Locomotion velocity, session 22.42.97.1-2.72.3-2.32.02.01.8-1.61.61.6-1.6-1.5-0.80.60.4-0.2
Locomotion distance, session 20.91.34.2-2.11.7-1.71.41.41.2-0.90.90.9-1.0-0.9-0.10.1-0.10.3
Locomotion velocity, session 35.86.87.6-2.52.7-2.72.82.82.7-2.82.82.8-2.7-2.7-2.42.42.3-2.1
Locomotion distance, session 30.00.00.10.0-0.00.00.00.00.0-0.20.20.2-0.10.0-0.30.10.2-0.1
Stereotopy head waving bouts, day 34.04.76.3-2.52.5-2.52.42.42.4-2.22.22.2-2.2-2.2-1.71.61.5-1.3
Stereotopy head waving duration, day 34.95.87.3-2.62.7-2.72.72.72.6-2.52.52.5-2.5-2.5-2.02.01.8-1.6
Locomotion velocity, session 70.60.71.2-1.11.0-1.01.01.00.9-0.80.80.8-0.8-0.8-0.50.50.5-0.4
Locomotion distance, session 70.10.10.20.5-0.40.4-0.3-0.2-0.20.0-0.0-0.00.10.1-0.30.30.3-0.4
Stereotopy head waving bouts, day 70.20.20.9-0.60.3-0.20.10.0-0.10.2-0.2-0.20.30.30.7-0.8-0.90.9
Stereotopy head waving duration, day 70.20.31.1-1.00.7-0.70.50.40.3-0.10.10.1-0.1-0.10.5-0.5-0.60.7
Locomotion velocity, session 80.40.52.0-1.41.0-1.00.70.70.5-0.30.30.3-0.3-0.30.4-0.5-0.70.8
Locomotion distance, session 80.00.10.3-0.50.4-0.40.30.30.2-0.10.10.1-0.2-0.20.1-0.1-0.10.2
Degree of sensitization distance0.40.40.50.5-0.60.6-0.6-0.6-0.60.7-0.7-0.70.60.60.6-0.6-0.50.5
Degree of sensitization stereotypy2.22.43.40.8-1.21.2-1.4-1.4-1.51.6-1.6-1.61.61.61.8-1.8-1.81.8
Conditioned locomotion1.21.43.92.0-1.61.6-1.4-1.4-1.31.1-1.1-1.11.11.00.4-0.3-0.2-0.0
Cocaine response after cond. corrected4.04.48.42.9-2.72.7-2.5-2.4-2.32.1-2.1-2.12.02.11.3-1.2-1.00.9
Cocaine response after cond. not corrected4.24.69.23.0-2.82.7-2.5-2.5-2.42.1-2.1-2.12.12.11.3-1.2-0.90.9
Cocaine response before conditioning0.40.40.8-0.90.8-0.80.80.80.7-0.70.70.7-0.6-0.7-0.40.40.3-0.3
Saline control response0.00.00.20.4-0.30.3-0.3-0.2-0.20.2-0.2-0.20.20.1-0.00.00.1-0.1
Bone: connectivity density0.71.02.9-0.5-0.10.2-0.5-0.5-0.70.9-0.9-0.91.01.01.5-1.6-1.71.6
Bone: cortical apparent density0.81.01.31.1-1.11.1-1.1-1.1-1.11.2-1.2-1.21.01.01.0-0.8-0.80.6
Bone: cortical area0.91.32.60.2-0.60.6-0.8-0.8-1.01.2-1.2-1.21.11.11.6-1.6-1.61.5
Bone: cortical porosity0.40.51.0-1.00.9-0.90.80.80.7-0.60.60.6-0.6-0.6-0.30.30.2-0.3
Bone: cortical porosity0.10.10.4-0.60.3-0.30.20.10.00.1-0.1-0.10.10.10.5-0.6-0.70.3
Bone: cortical thickness1.22.02.61.0-1.21.2-1.3-1.4-1.41.6-1.6-1.61.51.51.6-1.6-1.51.3
Bone: cortical thickness0.10.10.40.3-0.10.10.00.10.1-0.20.20.2-0.3-0.3-0.50.50.6-0.4
Bone: cortical tissue density0.50.70.90.9-0.90.9-0.9-0.9-0.90.9-0.9-0.90.80.80.8-0.7-0.60.5
Condit. Reinf. active minus inactive responses3.84.25.0-2.22.2-2.22.22.22.2-2.12.12.1-2.2-2.1-1.81.81.7-1.4
Condit. Reinf. active-inactive response ratio2.32.52.8-1.31.4-1.51.61.61.6-1.71.71.7-1.7-1.6-1.71.71.6-1.5
Condit. Reinf. active responses2.83.55.9-2.42.3-2.32.22.12.0-1.91.91.9-1.9-1.8-1.31.21.1-0.7
Condit. Reinf. inactive responses0.50.62.0-1.41.2-1.11.00.90.8-0.60.60.6-0.7-0.6-0.00.0-0.10.3
Incentive salience index mean1.72.13.9-2.01.8-1.81.71.61.6-1.41.41.4-1.5-1.4-0.90.90.7-0.4
Condit. Reinf. lever presses0.30.51.9-1.00.5-0.40.20.1-0.10.3-0.3-0.30.20.40.9-1.0-1.11.4
Condit. Reinf. active minus inactive responses2.73.44.1-1.21.6-1.61.71.81.8-1.91.91.9-1.9-1.9-2.02.02.0-2.0
Condit. Reinf. active-inactive response ratio0.50.61.60.40.0-0.00.30.30.4-0.70.70.7-0.7-0.6-1.11.21.3-1.2
Condit. Reinf. active responses2.33.13.5-1.71.8-1.81.91.91.9-1.81.81.8-1.9-1.8-1.61.71.6-1.5
Condit. Reinf. inactive responses1.01.22.4-1.51.4-1.41.31.31.2-1.01.01.0-1.1-1.1-0.70.70.6-0.4
Condit. Reinf. lever presses2.63.54.1-1.41.7-1.71.81.91.9-2.02.02.0-2.0-2.0-2.02.02.0-1.8
Condit. Reinf. lever reinforcers received1.82.62.9-1.31.5-1.51.61.61.7-1.71.71.7-1.7-1.7-1.61.61.6-1.5
Conditioned reinforcement - actives2.42.43.0-1.61.7-1.71.71.71.7-1.71.71.7-1.7-1.6-1.31.41.3-0.9
Conditioned reinforcement - inactives0.40.41.01.0-0.90.9-0.8-0.8-0.70.6-0.6-0.60.60.60.1-0.2-0.1-0.5
Conditioned locomotion7.79.210.5-3.03.2-3.23.23.23.2-3.23.23.2-3.2-2.9-2.82.82.6-2.3
Patch foraging indifference point 0 sec0.20.30.40.2-0.40.4-0.5-0.5-0.50.6-0.6-0.60.50.50.6-0.6-0.60.2
Patch foraging indifference point AUC1.01.21.4-0.81.0-1.11.11.11.1-1.21.21.2-1.2-1.1-1.11.11.1-0.5
Delay disc. indifference point, 0s delay8.39.111.81.9-2.52.5-2.8-2.8-3.03.1-3.1-3.13.13.23.4-3.4-3.43.4
Delay disc. indifference point, 16s delay0.20.20.20.3-0.30.3-0.4-0.4-0.40.4-0.4-0.40.40.40.4-0.5-0.50.4
Delay disc. indifference point, 2s delay6.26.87.62.0-2.42.4-2.6-2.6-2.72.7-2.7-2.72.72.82.7-2.7-2.72.7
Delay disc. indifference point, 24s delay0.50.50.60.8-0.80.8-0.8-0.8-0.80.7-0.7-0.70.80.70.6-0.6-0.50.8
Delay disc. indifference point, 4s delay1.51.62.80.6-0.90.9-1.1-1.1-1.21.3-1.3-1.31.31.21.5-1.5-1.61.7
Delay disc. indifference point, 8s delay0.90.91.41.2-1.21.2-1.1-1.1-1.11.0-1.0-1.01.01.00.6-0.7-0.60.4
Indifference point function ln k0.20.30.30.5-0.60.6-0.6-0.6-0.50.6-0.6-0.60.60.60.4-0.5-0.5-0.0
Indifference point function log k0.20.30.30.5-0.60.6-0.6-0.6-0.50.6-0.6-0.60.60.60.4-0.5-0.5-0.0
Patch foraging total patch changes 0 sec0.10.20.30.2-0.40.4-0.4-0.4-0.40.5-0.5-0.50.40.40.4-0.4-0.40.0
Patch foraging total patch changes 12 sec0.20.31.11.1-0.80.8-0.6-0.6-0.60.5-0.5-0.50.40.30.10.00.10.3
Patch foraging total patch changes 18 sec1.01.31.7-1.11.2-1.21.21.21.2-1.21.21.2-1.2-1.3-1.01.11.1-0.9
Patch foraging total patch changes 24 sec0.10.10.1-0.20.3-0.30.30.30.3-0.20.20.2-0.3-0.4-0.10.20.20.3
Patch foraging total patch changes 6 sec0.20.30.5-0.70.5-0.50.50.50.6-0.40.40.4-0.6-0.6-0.40.40.4-0.7
Patch foraging time to switch 0 sec1.92.94.21.0-1.31.4-1.6-1.6-1.71.9-1.9-1.91.81.72.0-2.1-2.11.6
Patch foraging water rate 0 sec0.20.41.30.4-0.00.00.20.20.4-0.50.50.5-0.5-0.4-1.01.11.1-0.9
Patch foraging water rate 12 sec0.60.92.91.7-1.41.4-1.2-1.1-1.00.8-0.8-0.80.80.80.2-0.00.10.1
Patch foraging water rate 18 sec0.91.14.00.7-0.10.10.30.30.5-0.80.80.8-0.9-0.8-1.61.82.0-1.6
Patch foraging water rate 24 sec0.60.82.61.6-1.01.0-0.6-0.5-0.3-0.10.10.1-0.10.0-1.11.21.4-1.6
Patch foraging water rate 6 sec0.91.33.00.10.4-0.40.70.70.9-1.11.11.1-1.1-1.0-1.61.61.7-1.7
Seeking ratio, delayed vs. immediate footshock4.34.97.6-2.82.5-2.52.52.42.4-2.32.32.3-2.2-2.1-1.81.71.5-1.4
Distance traveled before self-admin0.30.40.60.4-0.50.5-0.5-0.5-0.60.6-0.6-0.60.50.70.6-0.7-0.70.7
Distance traveled after self-admin0.70.81.1-1.01.0-1.01.01.00.9-0.90.90.9-1.0-0.8-0.70.60.6-0.5
Extensor digitorum longus weight3.814.921.34.6-4.64.6-4.4-4.4-4.23.9-3.9-3.93.94.12.8-2.8-2.52.1
Bone: elastic displacement0.30.30.4-0.60.6-0.60.60.60.6-0.60.60.6-0.5-0.5-0.50.40.3-0.5
Bone: elastic work0.20.30.60.1-0.30.3-0.4-0.4-0.50.6-0.6-0.60.60.60.7-0.8-0.80.5
Bone: endosteal estimation0.30.61.10.2-0.50.5-0.6-0.6-0.70.8-0.8-0.80.80.81.0-1.0-1.01.0
Bone: endosteal perimeter0.20.41.6-1.20.9-0.90.80.70.6-0.40.40.4-0.4-0.40.1-0.1-0.30.4
Epididymis fat weight0.20.51.0-0.10.4-0.40.60.60.6-0.80.80.8-0.8-0.7-1.01.01.0-0.7
Delta time in closed arm before/after self-admin0.60.62.41.6-1.11.1-0.8-0.7-0.60.3-0.3-0.30.30.3-0.60.60.8-0.6
Delta time in open arm before/after self-admin1.31.31.50.9-1.11.1-1.2-1.2-1.21.2-1.2-1.21.21.21.2-1.2-1.20.8
Diff in mean of infusions in LGA sessions1.61.82.1-1.21.3-1.41.41.41.4-1.41.41.4-1.4-1.4-1.21.21.2-1.2
Delay discount exponential model param2.12.22.4-1.21.4-1.41.51.51.5-1.51.51.5-1.5-1.5-1.51.51.5-1.5
Extinction: sum of active levers before priming1.81.83.0-0.60.9-0.91.11.21.3-1.41.41.4-1.4-1.2-1.61.71.7-1.6
Active lever presses in extinction session 62.92.83.4-1.71.8-1.81.81.81.8-1.81.81.8-1.8-1.6-1.41.51.4-1.2
Bone: final force1.52.53.70.7-1.11.2-1.3-1.4-1.51.7-1.7-1.71.61.61.9-1.9-1.91.9
Bone: final moment1.22.03.10.6-1.01.0-1.2-1.2-1.31.5-1.5-1.51.41.41.8-1.7-1.71.7
Food consumed during 24 hour testing period0.40.50.60.8-0.80.8-0.8-0.8-0.80.8-0.8-0.80.70.80.6-0.6-0.60.6
Glucose1.11.72.11.4-1.41.4-1.4-1.4-1.41.3-1.3-1.31.31.41.0-1.1-1.01.0
Heart weight0.40.61.2-0.30.5-0.50.70.70.7-0.90.90.9-0.8-0.8-1.01.01.1-0.8
Delay discount hyperbolic model param3.03.13.4-1.41.7-1.71.81.81.8-1.81.81.8-1.9-1.8-1.81.81.8-1.8
Intermittent access intake day 1-15 change7.47.38.1-2.52.6-2.62.72.82.8-2.82.82.8-2.8-2.7-2.62.62.5-2.6
Intermittent access intake escalation8.07.89.7-2.02.4-2.42.62.72.8-3.03.03.0-2.9-2.8-3.13.13.0-3.1
Intermittent access intake escalation 29.29.110.8-2.22.6-2.72.92.93.0-3.23.23.2-3.2-3.1-3.33.33.2-3.1
Intermitt. access day 1 inactive lever presses0.60.61.2-0.30.5-0.50.60.60.7-0.90.90.9-0.9-0.6-1.11.11.1-0.9
Intermitt. access day 15 inactive lever presses0.60.71.4-0.50.6-0.60.70.70.8-0.80.80.8-0.8-0.8-0.90.90.9-1.2
Intermitt. access escalation Index0.60.51.6-0.1-0.20.2-0.4-0.4-0.50.7-0.7-0.70.70.51.1-1.1-1.11.3
Intermittent access day 1 total infusions0.10.10.20.1-0.20.2-0.3-0.2-0.20.2-0.2-0.20.30.30.4-0.3-0.30.2
Intermittent access day 15 total infusions2.32.63.3-1.21.4-1.41.51.51.6-1.71.71.7-1.7-1.6-1.61.71.7-1.8
Intermittent access terminal intake (last 3 days)1.21.31.6-1.01.1-1.11.21.21.2-1.31.31.3-1.2-1.2-1.01.11.1-0.8
Intermittent access total infusions0.30.30.6-0.40.4-0.40.50.50.6-0.60.60.6-0.6-0.5-0.50.60.6-0.8
Intermittent access day 1 locomotion0.40.40.8-0.50.5-0.50.60.60.6-0.70.70.7-0.6-0.6-0.60.70.7-0.9
Intermittent access day 15 total locomotion3.94.24.9-1.81.9-1.92.02.12.1-2.22.22.2-2.2-1.9-2.02.01.9-2.1
Intermittent access total locomotion1.11.31.5-1.21.1-1.11.11.21.2-1.21.21.2-1.2-1.0-1.01.01.0-1.1
Intermittent access standard deviation3.53.74.5-1.51.8-1.81.91.92.0-2.12.12.1-2.1-1.8-1.92.02.0-1.6
Left kidney weight0.00.10.6-0.70.4-0.40.30.30.2-0.00.00.0-0.0-0.10.4-0.3-0.40.8
Right kidney weight1.33.64.5-2.12.1-2.12.12.12.1-1.91.91.9-2.0-1.9-1.51.51.4-1.2
Cocaine induced anxiety0.50.51.4-1.21.1-1.10.90.90.8-0.60.60.6-0.6-0.6-0.10.1-0.00.4
Post-drug Anxiety0.30.41.5-1.00.8-0.80.70.60.4-0.30.30.3-0.3-0.30.4-0.3-0.41.2
Baseline Anxiety0.10.10.30.10.0-0.00.10.10.2-0.20.20.2-0.3-0.3-0.40.50.5-0.4
Tail length3.39.911.0-2.73.0-3.13.23.23.2-3.33.33.3-3.3-3.2-3.23.13.0-3.0
Length with tail1.86.68.1-2.82.8-2.82.82.82.7-2.62.62.6-2.6-2.6-2.32.01.9-2.4
Length without tail0.10.21.1-1.00.5-0.50.30.30.3-0.00.00.00.00.00.3-0.5-0.60.0
Times rat made contact with spout0.10.20.60.8-0.60.6-0.5-0.5-0.40.3-0.3-0.30.30.3-0.10.10.2-0.2
Lifetime Intake0.10.10.1-0.30.3-0.30.30.30.3-0.40.40.4-0.3-0.3-0.20.30.3-0.2
Liver weight, left2.23.55.42.3-2.22.2-2.1-2.1-2.11.8-1.8-1.81.91.91.4-1.4-1.21.4
Liver weight, right1.72.93.31.6-1.71.7-1.8-1.8-1.81.7-1.7-1.71.81.81.5-1.6-1.51.6
Locomotor activity2.84.48.8-3.02.6-2.62.42.42.3-2.02.02.0-2.1-2.0-1.41.31.1-1.3
Locomotor testing distance1.72.94.9-2.22.1-2.01.91.91.9-1.71.71.7-1.7-1.7-1.21.11.0-1.1
Locomotor testing rearing0.10.10.2-0.00.1-0.10.20.20.2-0.30.30.3-0.3-0.3-0.40.40.5-0.1
Locomotion in novel chamber0.50.61.0-0.30.5-0.60.70.70.7-0.90.90.9-0.8-0.7-0.91.01.0-0.4
Locomotion in novel chamber post-restriction0.70.81.0-0.91.0-1.01.01.01.0-0.90.90.9-1.0-1.0-0.80.80.8-0.6
Fecal boli incidents, locomotor time 11.41.53.01.7-1.61.6-1.5-1.4-1.31.2-1.2-1.21.21.20.8-0.6-0.50.4
Change in fecal boli incidents, locomotor task0.30.31.0-1.00.8-0.80.60.60.5-0.30.30.3-0.3-0.30.2-0.3-0.40.6
Time >=10cm from walls, locomotor time 10.50.51.20.1-0.30.3-0.5-0.5-0.60.7-0.7-0.70.60.71.0-1.0-1.01.1
Bouts of movement, locomotor time 10.20.20.3-0.30.4-0.40.40.40.4-0.50.50.5-0.5-0.5-0.40.50.5-0.5
Total resting periods, locomotor time 10.20.30.3-0.50.5-0.50.50.50.5-0.50.50.5-0.6-0.5-0.40.40.4-0.4
Rest time, locomotor task time 10.10.20.3-0.50.5-0.50.50.50.4-0.40.40.4-0.5-0.3-0.20.20.2-0.1
Distance moved, locomotor task time 10.60.71.60.1-0.40.4-0.6-0.6-0.70.8-0.8-0.80.90.81.1-1.2-1.21.1
Vertical activity count, locomotor time 10.00.00.10.3-0.30.3-0.2-0.2-0.20.2-0.2-0.20.20.2-0.0-0.1-0.0-0.2
Time >=10cm from walls, locomotor time 20.80.91.51.2-1.21.2-1.1-1.1-1.00.9-0.9-0.90.81.00.6-0.6-0.50.4
Bouts of movement, locomotor time 20.30.31.0-1.00.8-0.80.70.60.5-0.40.40.4-0.4-0.30.0-0.1-0.20.3
Total resting periods, locomotor time 20.30.31.0-1.00.8-0.80.60.60.5-0.30.30.3-0.4-0.30.1-0.2-0.30.5
Rest time, locomotor task time 20.40.51.0-1.00.9-0.90.80.80.7-0.60.60.6-0.7-0.7-0.20.20.20.0
Distance moved, locomotor task time 20.60.61.31.1-1.11.1-1.0-0.9-0.90.8-0.8-0.80.80.80.4-0.4-0.3-0.0
Vertical activity count, locomotor time 20.50.61.71.3-1.11.1-0.9-0.9-0.80.6-0.6-0.60.50.70.00.00.1-0.4
Light reinforcement 15.29.512.0-3.53.4-3.43.33.33.3-3.13.13.1-3.1-3.2-2.72.62.4-2.6
Light reinforcement 21.72.33.0-1.71.6-1.61.61.61.6-1.51.51.5-1.5-1.6-1.31.21.1-1.6
Bone: marrow area0.30.61.10.2-0.50.5-0.6-0.7-0.70.8-0.8-0.80.80.81.0-1.0-1.01.0
Bone: maximum diameter0.50.92.9-1.71.4-1.41.21.11.0-0.70.70.7-0.8-0.80.00.0-0.10.2
Bone: maximum force1.52.53.50.9-1.21.3-1.4-1.4-1.61.7-1.7-1.71.61.61.9-1.8-1.81.7
Bone: maximum moment1.22.13.00.8-1.11.1-1.3-1.3-1.41.6-1.6-1.61.51.51.7-1.7-1.71.6
Mean time between licks in bursts4.36.06.8-2.12.3-2.32.52.52.5-2.52.52.5-2.6-2.6-2.52.52.4-2.4
Mean num. licks in bursts0.10.10.3-0.0-0.10.1-0.1-0.2-0.20.2-0.2-0.20.30.30.3-0.4-0.50.5
Cd content in liver0.20.20.30.3-0.40.4-0.5-0.5-0.50.5-0.5-0.50.50.50.5-0.5-0.50.4
Co content in liver0.70.81.3-0.60.7-0.80.80.80.9-0.90.90.9-0.9-0.9-1.01.01.0-1.2
Cu content in liver0.30.31.0-0.3-0.00.1-0.2-0.3-0.40.5-0.5-0.50.50.60.8-0.9-1.00.9
Fe content in liver0.10.10.30.2-0.00.00.10.10.2-0.20.20.2-0.2-0.3-0.40.50.5-0.6
K content in liver0.20.20.5-0.50.2-0.20.0-0.0-0.10.2-0.2-0.20.20.30.6-0.6-0.70.7
Mg content in liver0.20.31.1-0.60.2-0.20.0-0.0-0.10.2-0.2-0.20.20.40.7-0.8-0.91.0
Mn content in liver0.80.93.7-1.91.4-1.41.11.00.8-0.50.50.5-0.5-0.30.5-0.6-0.80.8
Na content in liver1.21.31.90.7-0.90.9-1.0-1.0-1.11.2-1.2-1.21.21.31.3-1.4-1.41.0
Rb content in liver0.70.92.00.0-0.40.4-0.6-0.6-0.70.9-0.9-0.90.90.91.3-1.3-1.41.4
Se content in liver0.10.20.3-0.50.5-0.50.50.40.4-0.40.40.4-0.4-0.3-0.20.30.2-0.1
Sr content in liver0.20.21.20.5-0.20.2-0.00.00.1-0.30.30.3-0.3-0.3-0.70.70.8-1.1
Zn content in liver2.93.25.6-0.61.1-1.11.41.51.6-1.91.91.9-1.9-1.7-2.32.32.4-2.1
Bone: minimum diameter0.10.20.6-0.40.1-0.1-0.0-0.1-0.20.3-0.3-0.30.30.30.7-0.7-0.70.8
Time in familiar zone, hab. session 12.32.12.4-1.21.4-1.41.41.51.5-1.51.51.5-1.5-1.5-1.51.51.4-1.4
Time in novel zone, hab. session 11.41.42.40.4-0.70.7-0.9-1.0-1.11.2-1.2-1.21.11.21.5-1.5-1.51.5
Total zone transitions, hab. session 10.60.82.4-1.51.3-1.31.11.10.9-0.70.70.7-0.8-0.7-0.10.1-0.10.2
Total locomotion distance, hab. session 10.71.03.9-2.01.5-1.51.21.11.0-0.60.60.6-0.6-0.60.3-0.4-0.60.7
Locomotion velocity, hab. session 10.91.34.1-2.01.7-1.71.41.41.2-1.01.01.0-1.0-1.0-0.20.1-0.10.2
Time in familiar zone, hab. session 26.87.08.1-2.12.4-2.42.62.62.7-2.82.82.8-2.7-2.7-2.82.82.7-2.6
Time in novel zone, hab. session 25.35.36.51.6-2.02.0-2.2-2.2-2.32.4-2.4-2.42.42.32.6-2.5-2.52.4
Total zone transitions, hab. session 20.70.92.4-0.3-0.20.2-0.4-0.5-0.60.9-0.9-0.90.80.81.4-1.4-1.51.6
Total locomotion distance, hab. session 20.50.72.0-1.41.2-1.21.01.00.9-0.70.70.7-0.7-0.7-0.10.1-0.00.2
Locomotion velocity, hab. session 20.50.62.3-1.51.2-1.21.00.90.8-0.60.60.6-0.6-0.60.1-0.1-0.30.4
Novel to familiar place preference ratio4.74.86.61.3-1.71.8-2.0-2.0-2.22.2-2.2-2.22.32.32.5-2.5-2.62.6
Novelty place preference2.93.04.60.9-1.31.3-1.5-1.6-1.71.7-1.7-1.71.81.82.0-2.1-2.12.1
Time in novel zone, NPP test3.23.34.71.0-1.41.5-1.7-1.7-1.81.8-1.8-1.81.92.02.1-2.1-2.22.2
Total zone transitions, NPP test0.10.20.5-0.20.0-0.0-0.1-0.1-0.20.4-0.4-0.40.30.30.6-0.6-0.70.7
Total locomotion distance, NPP test0.30.31.1-0.30.0-0.0-0.2-0.2-0.30.5-0.5-0.50.50.50.9-0.9-1.01.1
Locomotion velocity, NPP test0.10.20.6-0.60.3-0.30.10.1-0.00.2-0.2-0.20.20.20.6-0.6-0.70.8
Intraocular pressure0.30.41.40.6-0.20.20.10.10.2-0.50.50.5-0.4-0.5-0.91.11.2-0.6
Delta distance traveled before/after self-admin1.51.62.0-1.41.4-1.41.41.41.3-1.31.31.3-1.3-1.4-1.11.11.0-1.1
Delta ambulatory time before/after self-admin1.51.62.2-1.51.5-1.51.41.41.4-1.31.31.3-1.3-1.4-0.90.90.9-0.6
Parametrial fat weight0.51.01.3-0.80.9-0.91.01.01.0-1.11.11.1-1.0-1.0-1.11.01.0-1.1
Pavlov. Cond. lever latency0.20.30.90.5-0.10.10.10.10.2-0.30.30.3-0.4-0.4-0.80.80.9-1.0
Pavlov. Cond. magazine entry latency2.73.54.0-1.71.9-1.91.92.02.0-1.91.91.9-2.0-2.0-1.81.81.8-1.6
Pavlov. Cond. change in total contacts0.00.00.1-0.30.3-0.30.20.20.2-0.20.20.2-0.2-0.2-0.10.10.1-0.1
Pavlov. Cond. index score0.20.30.9-1.00.8-0.80.70.70.6-0.50.50.5-0.5-0.5-0.10.10.00.1
Pavlov. Cond. latency score0.20.31.2-1.10.8-0.80.70.60.6-0.40.40.4-0.4-0.40.1-0.1-0.20.4
Pavlov. Cond. lever contacts0.20.31.0-0.80.4-0.40.20.10.00.1-0.1-0.10.20.20.7-0.8-0.91.0
Pavlov. Cond. magazine entry number0.50.70.80.8-0.90.9-0.9-0.9-0.90.8-0.8-0.80.90.90.7-0.7-0.70.5
Pavlov. Cond. intertrial magazine entries0.20.30.80.20.1-0.20.30.30.4-0.40.40.4-0.6-0.6-0.70.90.9-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.4-1.21.1-1.11.01.00.9-0.80.80.8-0.8-0.8-0.40.40.3-0.1
Pavlov. Cond. response bias0.91.11.3-1.11.2-1.21.21.21.1-1.11.11.1-1.1-1.1-0.90.90.8-0.7
Pavlov. Cond. lever latency0.81.11.41.1-1.21.2-1.1-1.1-1.11.1-1.1-1.11.01.10.9-0.8-0.80.8
Pavlov. Cond. magazine entry latency0.50.51.0-1.00.9-0.90.80.80.8-0.80.80.8-0.7-0.7-0.50.40.4-0.1
Pavlov. Cond. change in total contacts0.91.21.5-1.01.1-1.11.11.11.1-1.21.21.2-1.1-1.1-1.11.00.9-1.0
Pavlov. Cond. index score1.01.21.4-1.11.2-1.21.21.21.2-1.21.21.2-1.1-1.1-1.00.90.9-0.8
Pavlov. Cond. latency score0.81.01.4-1.21.2-1.21.11.11.1-1.11.11.1-1.0-1.0-0.80.70.7-0.6
Pavlov. Cond. lever contacts0.91.21.4-0.91.0-1.01.11.11.1-1.21.21.2-1.1-1.1-1.11.01.0-1.0
Pavlov. Cond. magazine entry number0.70.91.61.3-1.21.2-1.1-1.1-1.01.0-1.0-1.01.00.90.7-0.6-0.50.3
Pavlov. Cond. intertrial magazine entries0.30.40.90.9-0.80.8-0.7-0.7-0.60.7-0.7-0.70.40.40.3-0.10.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.91.21.5-1.21.2-1.21.21.21.1-1.21.21.2-1.1-1.1-0.90.80.8-0.7
Pavlov. Cond. response bias2.02.73.2-1.41.6-1.61.71.71.7-1.81.81.8-1.7-1.7-1.71.61.5-1.5
Time in closed arm before self-admin1.21.32.40.3-0.70.8-0.9-1.0-1.11.2-1.2-1.21.31.21.5-1.5-1.61.2
Time in closed arm after self-admin0.00.00.00.10.0-0.00.10.10.1-0.00.00.0-0.1-0.2-0.20.20.2-0.0
Time in open arm before self-admin1.21.31.5-0.91.0-1.01.11.11.2-1.21.21.2-1.2-1.1-1.21.21.1-1.0
Time in open arm after self-admin0.50.60.80.8-0.90.9-0.9-0.9-0.80.8-0.8-0.80.80.90.5-0.6-0.60.2
Bone: periosteal estimation0.61.32.70.0-0.50.5-0.7-0.8-0.91.2-1.2-1.21.11.11.6-1.6-1.61.6
Bone: periosteal perimeter0.20.30.9-1.00.6-0.60.30.30.20.1-0.1-0.10.00.00.7-0.7-0.80.8
Bone: post-yield work0.60.81.00.9-0.90.9-0.9-0.9-0.91.0-1.0-1.00.80.80.9-0.7-0.70.7
Progressive ratio test 1 active lever presses0.10.10.20.5-0.40.4-0.3-0.3-0.30.2-0.2-0.20.20.20.10.00.1-0.1
Progressive ratio test 1 breakpoint0.10.10.30.6-0.50.5-0.4-0.4-0.40.3-0.3-0.30.30.30.3-0.1-0.10.1
Progressive ratio test 1 inactive lever presses0.00.00.0-0.10.1-0.10.10.10.1-0.10.10.1-0.1-0.1-0.00.00.0-0.2
Progressive ratio test 2 active lever presses0.30.40.7-0.20.4-0.40.50.50.6-0.70.70.7-0.7-0.5-0.70.80.8-0.5
Progressive ratio test 2 breakpoint0.30.30.5-0.50.6-0.60.60.60.6-0.70.70.7-0.7-0.5-0.50.60.6-0.1
Progressive ratio test 2 inactive lever presses0.00.10.1-0.30.3-0.30.30.30.3-0.30.30.3-0.2-0.1-0.10.10.1-0.0
Incentive Sensitization - Responses0.40.40.8-0.20.5-0.50.60.60.6-0.80.80.8-0.8-0.5-0.80.90.9-0.3
Incentive Sensitization - Breakpoint0.40.50.7-0.30.5-0.60.60.60.7-0.80.80.8-0.8-0.5-0.70.80.8-0.1
Sum of active levers in priming session hrs 5-60.00.00.10.1-0.00.00.00.00.1-0.10.10.1-0.10.1-0.10.10.1-0.3
Progressive ratio0.20.20.70.9-0.60.6-0.5-0.5-0.50.2-0.2-0.20.40.40.0-0.00.00.4
Food seeking constrained by brief footshock0.10.10.1-0.20.3-0.30.30.30.3-0.20.20.2-0.3-0.2-0.20.30.3-0.0
Seeking ratio, punishment vs. effort0.10.10.4-0.60.5-0.50.40.40.4-0.10.10.1-0.3-0.4-0.00.10.0-0.4
Retroperitoneal fat weight0.31.01.51.2-1.21.2-1.2-1.1-1.11.1-1.1-1.11.01.00.6-0.6-0.5-0.0
Reaction time number correct0.40.51.91.4-1.11.1-0.9-0.8-0.70.6-0.6-0.60.50.50.10.10.2-0.1
Reaction time mean minus median0.70.91.2-1.01.1-1.11.11.11.0-1.01.01.0-1.0-1.0-0.80.80.8-0.1
Reaction time mean minus median AUC0.20.31.9-0.70.4-0.40.20.1-0.00.1-0.1-0.10.20.20.7-0.7-0.91.4
Reaction time num false alarms0.00.00.10.4-0.30.3-0.2-0.2-0.10.1-0.1-0.10.00.1-0.10.20.2-0.0
Reaction time num false alarms AUC0.10.10.50.7-0.50.4-0.3-0.3-0.20.1-0.1-0.10.10.2-0.20.30.4-0.2
Reaction time trials correct on left0.40.51.91.4-1.11.1-0.9-0.8-0.70.6-0.6-0.60.50.50.10.10.2-0.1
Reaction time trials on left0.40.51.81.3-1.11.0-0.9-0.8-0.70.6-0.6-0.60.60.60.10.00.1-0.1
Reaction time mean0.20.21.5-0.40.2-0.20.0-0.0-0.10.3-0.3-0.30.20.10.7-0.6-0.71.2
Reaction time mean AUC0.20.31.4-0.40.1-0.1-0.1-0.1-0.20.4-0.4-0.40.30.20.8-0.7-0.81.2
Median of all reaction times0.50.72.20.1-0.30.4-0.5-0.6-0.70.8-0.8-0.80.80.71.2-1.1-1.11.5
Reaction time omissions0.20.30.5-0.70.7-0.70.60.60.6-0.50.50.5-0.6-0.5-0.30.30.3-0.2
Reaction time false alarm rate0.00.00.00.0-0.00.0-0.1-0.1-0.10.1-0.1-0.10.00.10.1-0.1-0.10.2
Reaction time premature initiation rate1.31.73.3-0.81.0-1.01.11.21.3-1.31.31.3-1.4-1.4-1.51.51.5-1.8
Reaction time premature initiations1.01.44.2-0.10.5-0.50.80.81.0-1.11.11.1-1.2-1.2-1.61.71.7-2.0
Std. dev. reaction times0.20.30.6-0.80.7-0.70.70.60.5-0.50.50.5-0.5-0.5-0.10.20.10.6
Reaction time trials completed0.40.51.81.3-1.11.0-0.9-0.8-0.70.6-0.6-0.60.60.60.10.00.1-0.1
Reaction time trials AUC0.30.51.91.4-1.11.0-0.8-0.8-0.70.5-0.5-0.50.50.5-0.00.20.3-0.2
Run reversals in cocaine runway, females0.30.30.7-0.80.8-0.80.70.70.6-0.50.50.5-0.5-0.5-0.20.20.10.4
Run reversals in cocaine runway, males0.90.91.4-1.11.2-1.21.11.11.1-0.90.90.9-1.0-1.0-0.50.60.5-0.1
Latency to leave start box in cocaine runway0.80.92.8-1.71.3-1.31.11.11.0-0.80.80.8-0.9-0.6-0.10.1-0.00.0
Latency to leave start box in cocaine runway, F0.50.52.2-0.90.4-0.40.10.1-0.10.4-0.4-0.40.20.51.2-1.1-1.21.5
Latency to leave start box in cocaine runway, M3.63.54.6-1.21.5-1.51.71.71.8-2.02.02.0-1.9-1.9-2.22.12.1-2.1
Std. dev. time between licks in bursts0.60.72.0-1.41.2-1.21.11.01.0-0.70.70.7-0.8-0.8-0.20.20.1-0.1
Total sessions with >9 infusions0.10.10.9-0.30.2-0.20.10.10.00.1-0.1-0.10.10.10.5-0.4-0.40.9
Short access day 1 total inactive lever presses0.00.00.1-0.10.2-0.20.20.20.2-0.20.20.2-0.2-0.3-0.20.20.2-0.2
Short access day 10 total inactive lever presses0.20.20.50.00.1-0.10.20.20.3-0.40.40.4-0.4-0.2-0.70.60.6-0.7
Short access day 1 total infusions0.10.10.4-0.60.5-0.50.40.40.3-0.20.20.2-0.1-0.20.4-0.2-0.30.5
Short access day 10 total infusions0.00.00.10.00.1-0.10.10.10.2-0.20.20.2-0.2-0.10.00.20.20.2
Short access total infusions0.10.10.6-0.10.1-0.10.10.00.0-0.00.00.00.00.10.4-0.2-0.20.8
Short access day 1 locomotion0.80.91.9-1.41.2-1.11.11.11.0-0.90.90.9-0.9-0.9-0.50.50.4-0.9
Short access day 10 total locomotion4.75.25.8-2.02.2-2.22.32.32.4-2.42.42.4-2.4-2.3-2.32.32.2-2.3
Short access total locomotion0.91.01.3-1.11.1-1.11.11.11.1-1.11.11.1-1.0-1.0-0.70.80.7-0.7
One hour access (0.3 mA shock)0.10.20.30.4-0.50.5-0.5-0.5-0.40.4-0.4-0.40.40.60.4-0.3-0.30.0
Compulsive drug intake1.21.21.50.7-1.01.0-1.1-1.1-1.11.2-1.2-1.21.21.21.0-1.2-1.20.8
One hour access (shock baseline)0.10.20.6-0.00.1-0.10.20.20.3-0.40.40.4-0.4-0.3-0.50.60.6-0.8
Social response proportion0.40.50.7-0.80.9-0.80.80.80.7-0.70.70.7-0.7-0.7-0.50.40.3-0.3
Social responses6.28.011.3-3.43.3-3.33.23.13.0-3.03.03.0-2.9-2.8-2.22.01.8-1.5
Social time0.50.71.01.0-1.01.0-1.0-0.9-0.90.9-0.9-0.90.90.80.6-0.6-0.60.4
Soleus weight8.424.628.55.0-5.35.3-5.3-5.3-5.35.2-5.2-5.25.25.34.4-4.4-4.23.6
Bone: stiffness3.35.26.11.8-2.12.1-2.2-2.3-2.32.5-2.5-2.52.32.32.4-2.3-2.32.0
Tibialis anterior weight1.03.44.51.7-1.91.9-2.0-2.0-2.01.8-1.8-1.81.92.11.6-1.7-1.61.6
Time to tail flick, vehicle, before self-admin0.40.41.4-1.20.9-0.90.70.70.6-0.50.50.5-0.4-0.30.1-0.1-0.20.8
Time to tail flick, vehicle, after self-admin0.20.30.80.40.0-0.00.20.20.3-0.40.40.4-0.4-0.6-0.80.80.9-0.6
Time to tail flick, test, before self-admin0.20.20.8-0.70.6-0.60.40.40.3-0.10.10.1-0.0-0.20.5-0.4-0.50.9
Time to tail flick, test, after self-admin0.10.10.3-0.60.5-0.50.50.40.4-0.30.30.3-0.3-0.30.1-0.1-0.10.5
Delta time to tail flick, vehicle, before/after SA0.40.42.01.4-1.00.9-0.7-0.7-0.60.4-0.4-0.40.40.2-0.30.40.5-0.6
Delta time to tail flick, test, before/after SA0.30.30.90.00.1-0.20.30.30.4-0.50.50.5-0.5-0.5-0.80.70.8-0.9
Tibia length1.02.83.1-1.51.6-1.61.71.71.7-1.81.81.8-1.7-1.8-1.71.61.5-1.6
Ambulatory time before self-admin0.20.20.40.4-0.40.4-0.5-0.5-0.50.4-0.4-0.40.50.70.5-0.5-0.60.5
Ambulatory time after self-admin0.40.40.6-0.70.8-0.80.70.70.7-0.70.70.7-0.8-0.6-0.50.50.4-0.4
Bone: tissue strength1.81.82.11.1-1.31.3-1.3-1.3-1.41.5-1.5-1.51.41.41.4-1.3-1.31.2
Total heroin consumption1.82.12.6-1.41.6-1.61.61.61.6-1.51.51.5-1.6-1.4-1.21.31.2-0.8
Bone: trabecular number0.50.83.2-1.81.3-1.31.01.00.9-0.70.70.7-0.6-0.60.0-0.2-0.40.4
Bone: trabecular spacing0.50.73.01.7-1.11.1-0.7-0.7-0.50.1-0.1-0.10.10.1-0.80.91.1-1.0
Bone: trabecular thickness1.21.44.7-1.60.7-0.60.10.0-0.20.7-0.7-0.70.70.71.8-1.9-2.21.9
Bone: trabecular tissue density1.52.24.72.2-1.91.9-1.7-1.7-1.61.6-1.6-1.61.41.41.0-0.8-0.60.2
Water consumed over 24 hours0.81.01.70.3-0.60.6-0.7-0.8-0.91.0-1.0-1.01.01.01.3-1.3-1.31.3
Number of responses in last shaping day0.20.20.3-0.50.5-0.50.50.50.5-0.40.40.4-0.4-0.3-0.30.30.3-0.3