Hub : Genes

Lyrm9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr10_64232959_64234965 0.02 0.02 6.5e-03 0.02 0.02 0.02 0.01 6.0e-03 5.5e-03 3.1e-03 8.5e-03
2 Brain mRNA stability Lyrm9 0.06 0.05 3.3e-05 0.05 0.05 0.05 0.05 1.5e-05 1.5e-05 1.6e-05 1.4e-05
3 Adipose mRNA stability Lyrm9 0.04 0.04 2.7e-04 0.01 0.02 0.01 0.01 1.0e-02 1.8e-03 1.1e-02 8.3e-03
4 Liver isoform ratio NM_001173471.1 0.02 0.02 3.4e-03 0.02 0.02 0.02 0.02 6.1e-03 2.9e-03 2.9e-03 3.5e-03
5 Liver intron excision ratio chr10_64223810_64232819 0.03 0.03 2.7e-03 0.01 0.01 0 0.01 1.3e-02 8.5e-03 1.5e-01 2.3e-02
6 NAcc mRNA stability Lyrm9 0.03 0.03 5.4e-05 0.02 0.03 0.03 0.03 2.9e-04 5.9e-05 8.6e-05 7.0e-05
7 NAcc gene expression Lyrm9 0.5 0.25 2.7e-04 0.01 0.02 0 0.01 2.7e-02 5.8e-04 4.8e-02 2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.83.44.42.1-1.9-1.91.91.9-1.91.1
Area under the delay curve0.60.91.2-0.20.91.1-1.0-1.11.10.8
BMI with tail2.06.810.43.2-2.5-2.62.62.6-2.61.9
BMI without tail1.05.47.12.7-2.3-2.42.42.4-2.41.5
Body weight2.812.314.13.8-3.5-3.63.63.6-3.63.1
Weight adjusted by age0.10.20.80.9-0.1-0.20.20.2-0.2-0.4
Bone surface1.42.84.82.2-1.7-1.71.71.7-1.70.8
Bone volume1.32.64.42.1-1.6-1.61.61.6-1.61.1
Breakpoint value in progressive ratio session0.10.20.3-0.1-0.4-0.50.50.5-0.5-0.6
Number of licking bursts0.20.61.6-1.30.70.7-0.7-0.70.7-0.7
Context. condit. distance diff. score0.60.81.71.3-0.8-0.80.80.8-0.80.6
Locomotion velocity, session 12.02.22.71.0-1.6-1.61.61.6-1.61.3
Locomotion distance, session 10.20.30.4-0.2-0.6-0.60.60.6-0.60.5
Locomotion velocity, session 20.00.00.1-0.3-0.1-0.10.10.1-0.1-0.2
Locomotion distance, session 20.91.31.80.7-1.3-1.31.31.3-1.30.6
Locomotion velocity, session 33.54.05.8-1.42.12.0-2.0-2.02.0-2.4
Locomotion distance, session 30.30.30.40.00.60.6-0.6-0.60.6-0.4
Stereotopy head waving bouts, day 30.10.10.4-0.10.1-0.00.00.0-0.0-0.6
Stereotopy head waving duration, day 31.21.53.7-1.31.10.9-1.0-0.90.9-1.9
Locomotion velocity, session 70.10.20.40.6-0.3-0.40.30.4-0.3-0.4
Locomotion distance, session 70.30.40.70.9-0.6-0.60.60.6-0.60.2
Stereotopy head waving bouts, day 70.40.50.91.0-0.7-0.70.70.7-0.70.3
Stereotopy head waving duration, day 70.10.20.40.7-0.3-0.40.40.4-0.4-0.3
Locomotion velocity, session 80.10.10.10.3-0.3-0.30.30.3-0.30.2
Locomotion distance, session 80.71.11.41.2-1.0-1.11.11.1-1.10.5
Degree of sensitization distance2.32.53.01.3-1.7-1.71.71.7-1.71.2
Degree of sensitization stereotypy0.50.50.70.9-0.7-0.80.70.8-0.70.3
Conditioned locomotion2.32.75.2-1.61.61.4-1.5-1.51.4-2.3
Cocaine response after cond. corrected1.11.72.10.7-1.4-1.41.41.4-1.41.0
Cocaine response after cond. not corrected1.62.32.71.1-1.6-1.71.61.6-1.71.2
Cocaine response before conditioning0.20.20.50.7-0.4-0.40.40.4-0.40.4
Saline control response0.00.10.2-0.10.20.1-0.1-0.10.1-0.5
Bone: connectivity density3.25.16.52.6-2.3-2.42.42.4-2.41.0
Bone: cortical apparent density0.61.01.9-1.41.00.9-0.9-0.90.9-1.0
Bone: cortical area0.91.41.9-0.51.31.4-1.4-1.41.4-0.8
Bone: cortical porosity0.20.20.70.8-0.4-0.40.40.5-0.40.3
Bone: cortical porosity0.10.10.60.8-0.3-0.30.30.3-0.30.2
Bone: cortical thickness2.44.04.8-1.42.22.2-2.2-2.22.2-1.6
Bone: cortical thickness0.10.10.4-0.40.30.3-0.3-0.30.3-0.7
Bone: cortical tissue density0.40.71.5-1.20.80.7-0.7-0.70.7-0.8
Condit. Reinf. active minus inactive responses0.80.90.9-0.71.01.0-1.0-1.01.0-1.0
Condit. Reinf. active-inactive response ratio0.20.20.20.20.40.5-0.4-0.40.5-0.3
Condit. Reinf. active responses0.00.10.2-0.40.10.1-0.2-0.10.1-0.4
Condit. Reinf. inactive responses0.20.30.4-0.5-0.6-0.60.60.6-0.60.1
Incentive salience index mean0.20.30.4-0.10.60.6-0.6-0.60.6-0.7
Condit. Reinf. lever presses0.20.31.21.1-0.4-0.40.40.4-0.40.1
Condit. Reinf. active minus inactive responses0.91.43.1-1.41.00.9-1.0-0.90.9-1.8
Condit. Reinf. active-inactive response ratio0.71.11.8-1.30.90.9-0.9-0.90.9-1.3
Condit. Reinf. active responses0.60.92.4-1.00.80.8-0.8-0.80.8-1.5
Condit. Reinf. inactive responses0.00.00.10.30.10.0-0.00.00.0-0.4
Condit. Reinf. lever presses2.63.84.2-2.02.01.9-1.9-1.91.9-2.0
Condit. Reinf. lever reinforcers received0.91.22.5-1.21.01.0-1.0-1.01.0-1.6
Conditioned reinforcement - actives0.10.50.60.8-0.8-0.70.70.7-0.70.6
Conditioned reinforcement - inactives0.20.51.00.9-0.7-0.50.50.5-0.51.0
Conditioned locomotion0.91.33.21.8-1.0-0.90.90.8-0.91.4
Patch foraging indifference point 0 sec0.30.91.5-0.60.90.9-0.9-0.90.9-1.2
Patch foraging indifference point AUC1.53.65.4-2.31.81.7-1.8-1.81.7-2.0
Delay disc. indifference point, 0s delay0.40.50.7-0.30.80.8-0.8-0.80.80.4
Delay disc. indifference point, 16s delay0.50.72.7-0.20.50.7-0.6-0.70.71.6
Delay disc. indifference point, 2s delay2.22.42.7-1.61.61.6-1.6-1.61.6-1.0
Delay disc. indifference point, 24s delay0.50.91.11.0-0.9-0.90.90.9-0.90.9
Delay disc. indifference point, 4s delay0.20.20.70.10.30.3-0.3-0.30.30.8
Delay disc. indifference point, 8s delay0.20.40.6-0.10.60.7-0.7-0.80.70.3
Indifference point function ln k0.30.81.11.1-0.9-0.80.90.9-0.81.0
Indifference point function log k0.30.81.11.1-0.9-0.80.90.9-0.81.0
Patch foraging total patch changes 0 sec0.30.81.6-0.60.90.8-0.9-0.80.8-1.3
Patch foraging total patch changes 12 sec0.20.20.4-0.70.40.4-0.4-0.40.4-0.5
Patch foraging total patch changes 18 sec1.33.03.6-1.91.71.6-1.7-1.61.6-1.9
Patch foraging total patch changes 24 sec1.13.95.4-2.31.81.9-1.9-1.91.8-2.2
Patch foraging total patch changes 6 sec2.64.44.8-2.02.12.2-2.2-2.22.2-1.8
Patch foraging time to switch 0 sec0.72.83.01.6-1.6-1.71.71.7-1.71.7
Patch foraging water rate 0 sec0.93.54.6-2.11.81.8-1.8-1.81.8-1.8
Patch foraging water rate 12 sec0.00.10.20.3-0.4-0.40.40.4-0.40.1
Patch foraging water rate 18 sec0.40.81.60.8-0.9-0.80.80.8-0.81.3
Patch foraging water rate 24 sec0.10.10.2-0.00.30.4-0.4-0.40.40.1
Patch foraging water rate 6 sec1.11.71.8-1.41.31.3-1.3-1.31.3-1.0
Seeking ratio, delayed vs. immediate footshock1.01.42.0-0.61.31.4-1.4-1.41.4-0.3
Distance traveled before self-admin1.94.24.8-1.52.12.2-2.2-2.22.2-2.0
Distance traveled after self-admin0.00.10.10.10.20.3-0.3-0.30.3-0.1
Extensor digitorum longus weight0.93.55.22.3-1.7-1.81.81.8-1.81.7
Bone: elastic displacement2.53.13.5-1.61.81.9-1.9-1.91.9-1.5
Bone: elastic work7.39.511.3-2.33.23.3-3.3-3.43.3-2.5
Bone: endosteal estimation0.00.00.10.1-0.2-0.10.10.1-0.10.4
Bone: endosteal perimeter0.10.10.30.3-0.4-0.30.30.3-0.30.6
Epididymis fat weight5.628.329.35.1-5.4-5.45.45.4-5.45.2
Delta time in closed arm before/after self-admin3.23.03.8-1.91.81.8-1.8-1.81.8-1.2
Delta time in open arm before/after self-admin6.07.18.12.8-2.8-2.72.72.7-2.72.2
Diff in mean of infusions in LGA sessions0.30.60.70.6-0.9-0.90.90.9-0.90.6
Delay discount exponential model param0.40.60.80.2-0.8-0.90.90.9-0.9-0.6
Extinction: sum of active levers before priming0.50.81.00.9-1.0-0.90.90.9-0.90.3
Active lever presses in extinction session 60.30.31.70.3-0.1-0.20.20.2-0.2-1.3
Bone: final force0.20.30.60.80.50.6-0.6-0.60.6-0.2
Bone: final moment0.20.40.70.80.60.6-0.6-0.60.6-0.1
Food consumed during 24 hour testing period0.20.40.5-0.30.70.7-0.7-0.70.7-0.6
Glucose1.52.33.7-1.91.51.5-1.5-1.51.5-1.0
Heart weight1.11.72.11.3-1.3-1.41.41.4-1.40.5
Delay discount hyperbolic model param0.70.91.30.4-1.0-1.11.11.1-1.1-0.3
Intermittent access intake day 1-15 change0.00.00.00.0-0.1-0.10.10.1-0.10.1
Intermittent access intake escalation0.00.10.20.3-0.3-0.20.30.3-0.30.4
Intermittent access intake escalation 20.10.20.2-0.30.50.4-0.4-0.40.4-0.2
Intermitt. access day 1 inactive lever presses0.00.10.10.20.30.3-0.3-0.40.3-0.1
Intermitt. access day 15 inactive lever presses0.21.03.0-1.70.80.8-0.8-0.80.8-0.7
Intermitt. access escalation Index0.61.94.21.2-1.2-1.21.21.2-1.22.0
Intermittent access day 1 total infusions0.20.50.60.7-0.7-0.70.70.7-0.70.7
Intermittent access day 15 total infusions0.71.71.91.3-1.4-1.31.31.2-1.31.3
Intermittent access terminal intake (last 3 days)1.11.92.21.4-1.5-1.31.31.3-1.31.5
Intermittent access total infusions0.60.70.90.9-0.9-0.80.80.8-0.80.8
Intermittent access day 1 locomotion0.10.30.80.9-0.4-0.40.40.3-0.40.6
Intermittent access day 15 total locomotion0.20.81.51.2-0.9-0.80.80.8-0.80.6
Intermittent access total locomotion0.81.01.71.3-1.0-1.00.90.9-1.00.8
Intermittent access standard deviation0.00.10.5-0.1-0.2-0.20.20.1-0.20.7
Left kidney weight0.00.40.80.9-0.5-0.50.50.5-0.50.8
Right kidney weight0.10.91.01.0-0.9-0.90.90.9-0.90.9
Cocaine induced anxiety0.10.20.5-0.70.40.4-0.4-0.40.4-0.3
Post-drug Anxiety0.10.10.1-0.2-0.3-0.30.30.3-0.3-0.1
Baseline Anxiety0.00.10.10.1-0.3-0.30.30.4-0.3-0.2
Tail length0.31.52.01.0-1.3-1.21.21.2-1.21.4
Length with tail0.62.84.41.4-1.7-1.61.61.6-1.62.1
Length without tail0.41.93.61.3-1.2-1.21.31.2-1.21.9
Times rat made contact with spout0.10.20.40.00.40.4-0.4-0.40.4-0.6
Lifetime Intake1.01.31.61.2-1.2-1.11.11.0-1.11.3
Liver weight, left4.47.68.52.4-2.9-2.92.92.9-2.92.3
Liver weight, right3.86.77.72.8-2.6-2.72.72.7-2.71.9
Locomotor activity0.00.10.2-0.40.20.2-0.2-0.20.20.2
Locomotor testing distance0.10.10.5-0.70.30.3-0.3-0.30.30.1
Locomotor testing rearing0.10.41.7-1.30.40.4-0.4-0.40.4-0.5
Locomotion in novel chamber1.52.02.8-0.51.61.7-1.7-1.71.7-0.7
Locomotion in novel chamber post-restriction0.10.31.81.3-0.0-0.00.00.0-0.00.4
Fecal boli incidents, locomotor time 10.51.41.81.2-1.2-1.31.31.3-1.30.4
Change in fecal boli incidents, locomotor task0.20.21.10.5-0.00.1-0.1-0.10.11.0
Time >=10cm from walls, locomotor time 10.20.31.91.4-0.1-0.20.20.2-0.10.1
Bouts of movement, locomotor time 10.30.30.5-0.20.60.7-0.7-0.70.7-0.2
Total resting periods, locomotor time 10.10.10.1-0.10.40.4-0.4-0.40.4-0.3
Rest time, locomotor task time 10.10.20.60.8-0.2-0.30.20.3-0.3-0.6
Distance moved, locomotor task time 10.10.20.3-0.30.40.5-0.4-0.50.50.6
Vertical activity count, locomotor time 10.00.21.10.5-0.00.1-0.0-0.10.01.0
Time >=10cm from walls, locomotor time 20.82.26.22.5-1.2-1.21.21.2-1.21.3
Bouts of movement, locomotor time 20.10.50.7-0.90.70.7-0.7-0.70.7-0.4
Total resting periods, locomotor time 20.10.20.4-0.60.40.4-0.4-0.40.4-0.5
Rest time, locomotor task time 20.71.15.4-1.10.60.4-0.5-0.40.4-2.3
Distance moved, locomotor task time 20.20.32.10.10.00.2-0.2-0.20.21.4
Vertical activity count, locomotor time 20.41.06.11.1-0.20.1-0.0-0.10.12.5
Light reinforcement 10.00.00.10.1-0.00.0-0.0-0.00.00.2
Light reinforcement 20.20.40.5-0.50.70.7-0.7-0.70.7-0.4
Bone: marrow area0.00.00.10.1-0.2-0.10.10.1-0.10.3
Bone: maximum diameter0.10.30.40.10.60.6-0.6-0.60.6-0.2
Bone: maximum force0.20.50.70.30.70.8-0.8-0.80.8-0.2
Bone: maximum moment0.30.60.80.30.80.9-0.9-0.90.9-0.1
Mean time between licks in bursts0.21.01.10.8-1.0-1.01.01.0-1.00.9
Mean num. licks in bursts0.20.52.01.4-0.6-0.60.60.6-0.60.5
Cd content in liver0.60.61.5-1.20.70.8-0.7-0.80.7-0.4
Co content in liver0.30.40.7-0.40.80.7-0.7-0.70.7-0.3
Cu content in liver2.12.63.5-1.71.51.5-1.5-1.51.5-1.9
Fe content in liver2.02.53.51.1-1.9-1.71.71.7-1.71.1
K content in liver0.20.20.30.4-0.4-0.40.40.4-0.40.6
Mg content in liver0.70.81.0-0.90.80.8-0.8-0.80.8-1.0
Mn content in liver0.40.40.6-0.80.70.6-0.6-0.60.6-0.7
Na content in liver0.40.51.7-0.3-0.6-0.50.50.5-0.51.3
Rb content in liver0.10.10.20.4-0.2-0.30.30.3-0.30.5
Se content in liver0.81.01.8-1.30.80.8-0.9-0.90.8-1.3
Sr content in liver0.40.31.00.3-0.5-0.50.50.5-0.41.0
Zn content in liver0.40.50.80.4-0.9-0.70.70.7-0.70.6
Bone: minimum diameter0.00.00.1-0.20.20.2-0.3-0.30.2-0.1
Time in familiar zone, hab. session 10.20.20.3-0.20.40.5-0.5-0.50.50.2
Time in novel zone, hab. session 10.10.10.1-0.1-0.3-0.30.30.3-0.3-0.1
Total zone transitions, hab. session 10.00.00.1-0.40.00.1-0.1-0.10.10.4
Total locomotion distance, hab. session 10.10.20.6-0.70.30.4-0.4-0.40.4-0.1
Locomotion velocity, hab. session 10.30.40.8-0.90.60.7-0.6-0.70.7-0.3
Time in familiar zone, hab. session 20.40.41.0-1.00.60.5-0.5-0.50.5-0.9
Time in novel zone, hab. session 20.10.10.10.40.20.2-0.2-0.20.20.3
Total zone transitions, hab. session 20.20.30.40.1-0.6-0.60.60.6-0.60.4
Total locomotion distance, hab. session 20.30.41.4-1.20.40.4-0.4-0.40.4-0.8
Locomotion velocity, hab. session 20.30.41.5-1.20.40.4-0.4-0.40.4-0.7
Novel to familiar place preference ratio0.81.01.21.1-1.0-1.01.01.0-1.01.0
Novelty place preference1.01.31.61.3-1.1-1.11.11.1-1.11.1
Time in novel zone, NPP test1.11.31.61.2-1.1-1.21.21.2-1.21.0
Total zone transitions, NPP test0.00.00.1-0.3-0.2-0.20.20.2-0.2-0.0
Total locomotion distance, NPP test1.21.74.1-2.01.11.1-1.1-1.11.1-1.3
Locomotion velocity, NPP test1.42.04.4-2.11.21.2-1.2-1.21.2-1.3
Intraocular pressure1.21.92.8-1.71.41.3-1.3-1.31.3-1.3
Delta distance traveled before/after self-admin3.03.34.32.1-1.9-1.81.81.8-1.81.6
Delta ambulatory time before/after self-admin1.62.73.11.3-1.8-1.71.71.7-1.71.7
Parametrial fat weight5.212.314.42.8-3.6-3.83.83.8-3.82.9
Pavlov. Cond. lever latency0.00.00.3-0.5-0.0-0.00.00.1-0.0-0.0
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.2-0.20.20.2-0.20.1
Pavlov. Cond. change in total contacts0.30.30.4-0.50.60.6-0.6-0.60.6-0.6
Pavlov. Cond. index score0.00.00.10.30.10.0-0.1-0.10.0-0.0
Pavlov. Cond. latency score0.00.00.20.4-0.1-0.10.10.1-0.10.0
Pavlov. Cond. lever contacts0.10.10.30.6-0.1-0.10.10.1-0.10.3
Pavlov. Cond. magazine entry number0.10.10.10.3-0.3-0.30.30.3-0.30.3
Pavlov. Cond. intertrial magazine entries0.40.50.9-1.00.60.6-0.6-0.60.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.20.1-0.2-0.20.1-0.1
Pavlov. Cond. response bias0.00.00.10.3-0.0-0.10.00.0-0.10.1
Pavlov. Cond. lever latency2.94.06.62.6-2.0-1.91.91.9-1.91.8
Pavlov. Cond. magazine entry latency0.20.30.5-0.70.50.5-0.5-0.50.5-0.4
Pavlov. Cond. change in total contacts0.92.22.9-1.71.51.5-1.5-1.51.5-1.4
Pavlov. Cond. index score2.33.65.9-2.41.81.8-1.8-1.81.8-1.7
Pavlov. Cond. latency score2.64.16.7-2.62.01.9-1.9-1.91.9-1.8
Pavlov. Cond. lever contacts1.72.54.0-2.01.61.5-1.5-1.51.4-1.7
Pavlov. Cond. magazine entry number0.10.10.40.7-0.1-0.10.10.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.20.50.60.8-0.8-0.80.80.8-0.80.4
Pavlov. Cond. lever-magazine prob. diff.1.82.74.7-2.21.61.5-1.5-1.51.5-1.5
Pavlov. Cond. response bias1.42.03.6-1.91.41.3-1.3-1.31.3-1.3
Time in closed arm before self-admin1.52.53.21.5-1.6-1.61.61.5-1.61.8
Time in closed arm after self-admin0.40.50.8-0.70.60.7-0.6-0.60.60.9
Time in open arm before self-admin2.63.24.1-1.81.81.7-1.7-1.71.7-2.0
Time in open arm after self-admin0.91.01.91.4-1.0-1.01.01.0-1.00.5
Bone: periosteal estimation0.20.40.5-0.20.60.7-0.7-0.70.7-0.3
Bone: periosteal perimeter0.10.20.20.20.40.4-0.4-0.50.40.3
Bone: post-yield work0.40.71.41.2-0.7-0.70.70.7-0.71.0
Progressive ratio test 1 active lever presses0.10.20.3-0.40.40.6-0.6-0.60.60.2
Progressive ratio test 1 breakpoint0.20.30.4-0.50.50.6-0.6-0.60.60.2
Progressive ratio test 1 inactive lever presses0.41.01.5-0.61.01.2-1.2-1.21.20.2
Progressive ratio test 2 active lever presses0.20.30.3-0.50.40.6-0.6-0.60.6-0.5
Progressive ratio test 2 breakpoint0.20.30.3-0.60.40.5-0.6-0.60.5-0.6
Progressive ratio test 2 inactive lever presses0.00.10.1-0.00.10.3-0.3-0.30.30.1
Incentive Sensitization - Responses0.00.10.8-0.1-0.1-0.10.00.0-0.1-0.9
Incentive Sensitization - Breakpoint0.10.10.9-0.2-0.1-0.10.10.1-0.1-1.0
Sum of active levers in priming session hrs 5-61.31.21.41.2-1.2-1.21.11.1-1.20.5
Progressive ratio0.10.31.60.60.20.0-0.1-0.00.1-1.3
Food seeking constrained by brief footshock0.10.10.10.1-0.3-0.30.30.3-0.30.2
Seeking ratio, punishment vs. effort0.10.31.7-0.3-0.10.0-0.0-0.10.01.3
Retroperitoneal fat weight0.62.64.31.0-1.6-1.61.61.6-1.62.1
Reaction time number correct0.41.31.41.2-1.1-1.21.21.2-1.21.1
Reaction time mean minus median0.00.20.3-0.3-0.6-0.50.50.5-0.50.1
Reaction time mean minus median AUC0.32.22.90.6-1.7-1.61.61.6-1.61.3
Reaction time num false alarms4.47.58.8-2.03.02.9-2.9-2.92.9-2.4
Reaction time num false alarms AUC3.37.69.2-1.83.03.0-3.0-2.93.0-2.5
Reaction time trials correct on left0.41.31.41.2-1.1-1.21.21.2-1.21.1
Reaction time trials on left0.41.41.61.2-1.1-1.21.21.2-1.21.1
Reaction time mean0.30.71.0-0.1-1.0-1.01.01.0-1.00.5
Reaction time mean AUC0.20.60.8-0.1-0.9-0.90.90.9-0.90.5
Median of all reaction times0.30.50.7-0.4-0.8-0.80.80.8-0.80.3
Reaction time omissions1.32.23.01.7-1.5-1.41.41.4-1.41.4
Reaction time false alarm rate5.77.99.2-2.03.03.0-3.0-3.03.0-2.5
Reaction time premature initiation rate0.40.61.21.1-0.6-0.60.60.6-0.61.0
Reaction time premature initiations0.31.01.91.4-0.8-0.90.90.9-0.91.2
Std. dev. reaction times0.31.01.40.5-1.2-1.11.11.1-1.10.8
Reaction time trials completed0.41.41.61.2-1.1-1.21.21.2-1.21.1
Reaction time trials AUC0.31.11.41.2-1.0-1.01.01.1-1.00.9
Run reversals in cocaine runway, females0.10.10.1-0.3-0.2-0.20.20.3-0.20.2
Run reversals in cocaine runway, males0.30.41.21.0-0.4-0.30.30.3-0.31.1
Latency to leave start box in cocaine runway1.62.38.5-1.11.21.1-1.1-1.01.1-2.9
Latency to leave start box in cocaine runway, F0.70.83.7-0.80.70.5-0.6-0.50.5-1.9
Latency to leave start box in cocaine runway, M0.90.93.9-0.20.80.7-0.7-0.60.7-2.0
Std. dev. time between licks in bursts0.10.10.40.3-0.3-0.20.20.2-0.20.6
Total sessions with >9 infusions1.31.63.71.5-1.1-1.01.00.9-1.01.9
Short access day 1 total inactive lever presses3.36.510.03.2-2.5-2.42.42.4-2.42.7
Short access day 10 total inactive lever presses0.00.10.60.8-0.1-0.00.00.0-0.00.6
Short access day 1 total infusions1.12.35.11.7-1.4-1.21.21.2-1.22.3
Short access day 10 total infusions0.61.02.20.7-1.0-0.90.90.9-0.91.5
Short access total infusions0.70.92.61.0-0.9-0.80.80.7-0.81.6
Short access day 1 locomotion0.20.31.60.7-0.4-0.10.20.1-0.21.2
Short access day 10 total locomotion0.10.40.6-0.70.70.7-0.7-0.80.7-0.2
Short access total locomotion0.10.20.40.30.30.5-0.5-0.50.50.6
One hour access (0.3 mA shock)0.00.00.1-0.30.20.1-0.1-0.10.1-0.4
Compulsive drug intake0.71.11.30.9-1.0-1.11.11.1-1.10.7
One hour access (shock baseline)0.00.10.2-0.40.30.4-0.4-0.40.4-0.2
Social response proportion2.83.54.82.2-1.8-1.81.81.8-1.82.0
Social responses2.02.62.71.6-1.6-1.71.71.7-1.71.5
Social time1.93.04.31.9-1.7-1.61.61.6-1.62.1
Soleus weight2.36.78.02.8-2.6-2.72.62.6-2.72.0
Bone: stiffness2.03.64.92.2-1.9-1.81.81.8-1.81.9
Tibialis anterior weight2.79.410.73.3-3.1-3.13.13.1-3.12.5
Time to tail flick, vehicle, before self-admin0.30.41.40.6-0.5-0.40.40.4-0.41.2
Time to tail flick, vehicle, after self-admin0.10.30.3-0.40.50.6-0.6-0.60.60.1
Time to tail flick, test, before self-admin0.00.00.1-0.30.1-0.00.00.0-0.0-0.1
Time to tail flick, test, after self-admin2.22.35.7-2.21.21.1-1.1-1.01.1-2.4
Delta time to tail flick, vehicle, before/after SA0.91.01.9-1.40.90.8-0.8-0.80.8-1.3
Delta time to tail flick, test, before/after SA0.60.81.2-1.10.80.8-0.8-0.80.8-1.0
Tibia length0.00.00.10.20.00.2-0.2-0.20.20.3
Ambulatory time before self-admin0.41.21.7-0.31.21.3-1.3-1.31.3-0.5
Ambulatory time after self-admin0.00.10.30.5-0.2-0.10.10.1-0.10.4
Bone: tissue strength1.11.11.6-0.11.21.2-1.2-1.21.2-0.6
Total heroin consumption1.61.92.61.0-1.5-1.61.61.6-1.6-0.2
Bone: trabecular number2.14.04.71.9-2.1-2.22.12.2-2.21.0
Bone: trabecular spacing0.10.20.30.20.50.5-0.5-0.50.5-0.1
Bone: trabecular thickness0.00.00.00.1-0.1-0.00.00.0-0.00.1
Bone: trabecular tissue density1.22.03.4-1.81.41.4-1.4-1.41.4-1.2
Water consumed over 24 hours0.00.00.1-0.10.20.2-0.2-0.20.2-0.1
Number of responses in last shaping day0.50.61.0-0.20.81.0-1.0-1.01.0-0.0