Hub : Genes

Ly6g6d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ly6g6d 0.06 0.03 2.2e-08 0.01 0.04 0.02 0.02 1.6e-02 9.1e-07 2.5e-04 1.1e-04
2 Brain alternative TSS NM_001001970.2 0.03 0.02 7.9e-03 0.01 0.02 0.01 0.01 3.6e-02 5.7e-03 3.7e-02 5.6e-02
3 Brain alternative TSS NM_001412147.1 0.03 0.02 7.8e-03 0.01 0.02 0.01 0.01 3.7e-02 5.9e-03 2.4e-02 4.9e-02
4 pVTA intron excision ratio chr20_3754544_3756628 0.06 0.04 2.9e-04 0.02 0.03 0 0.02 9.7e-03 1.5e-03 1.8e-01 4.9e-03
5 Brain isoform ratio NM_001001970.2 0.03 0.02 7.4e-03 0.01 0.02 0.01 0.01 3.2e-02 5.1e-03 3.8e-02 1.3e-02
6 Brain isoform ratio NM_001412147.1 0.03 0.02 9.0e-03 0.01 0.02 0.01 0.01 2.0e-02 6.2e-03 3.1e-02 1.4e-02
7 Brain intron excision ratio chr20_3754544_3756628 0.06 0.04 8.7e-04 0.02 0.02 0.01 0.01 7.3e-03 4.1e-03 6.6e-02 2.3e-02
8 Brain mRNA stability Ly6g6d 0.09 0.05 7.7e-07 0.05 0.06 0.06 0.06 4.0e-05 1.1e-06 2.9e-06 2.1e-06
9 LHb gene expression Ly6g6d 0.31 0.14 1.8e-05 0.24 0.19 0.18 0.18 2.3e-06 2.7e-05 5.3e-05 5.2e-05
10 BLA gene expression Ly6g6d 0.24 0.12 1.3e-07 0.05 0.12 0.11 0.12 1.1e-03 6.0e-07 2.7e-06 7.6e-07
11 Adipose gene expression Ly6g6d 0.04 0.02 4.9e-04 0.04 0.01 0.02 0.03 5.4e-05 9.0e-03 6.4e-03 8.2e-04
12 RMTg gene expression Ly6g6d 0.36 0.15 2.0e-06 0.3 0.18 0.2 0.24 1.4e-08 1.7e-05 5.5e-06 5.4e-07
13 pVTA gene expression Ly6g6d 0.39 0.12 0.0e+00 0.36 0.38 0.37 0.36 1.1e-30 1.9e-32 8.0e-31 2.0e-30
14 Liver gene expression Ly6g6d 0.04 0.03 4.8e-03 0.02 -0 -0 0 3.1e-03 5.7e-01 4.6e-01 3.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.83.17.02.6-1.71.71.5-1.71.7-1.1-0.01.92.41.71.72.01.6
Area under the delay curve0.20.31.1-0.90.4-0.4-0.30.4-0.40.20.3-0.4-0.5-0.3-0.3-0.3-1.0
BMI with tail0.82.78.30.41.7-1.7-1.91.7-1.7-1.2-2.9-1.8-0.1-1.7-1.7-1.51.5
BMI without tail2.57.611.3-1.73.4-3.4-3.43.3-3.3-1.5-2.9-3.0-1.5-3.0-3.0-2.6-1.0
Body weight2.812.117.6-2.73.8-3.8-3.93.9-3.90.2-3.2-4.2-3.2-3.9-3.9-4.2-0.2
Weight adjusted by age3.45.17.7-2.42.3-2.3-2.32.4-2.50.7-1.5-2.7-2.7-2.4-2.4-2.8-1.0
Bone surface0.00.00.3-0.1-0.10.10.1-0.10.10.50.10.0-0.2-0.1-0.1-0.20.3
Bone volume0.10.10.50.7-0.20.20.1-0.20.2-0.4-0.40.20.60.20.20.30.6
Breakpoint value in progressive ratio session0.20.20.60.0-0.50.50.5-0.50.50.30.80.50.20.30.30.40.1
Number of licking bursts0.50.83.1-0.8-0.90.80.9-0.80.81.81.70.6-0.70.40.40.0-0.1
Context. condit. distance diff. score4.15.08.10.9-2.82.82.9-2.72.62.52.61.90.22.12.11.31.8
Locomotion velocity, session 10.40.41.5-0.4-0.60.60.8-0.60.60.71.20.5-0.30.40.40.4-0.8
Locomotion distance, session 11.51.82.91.7-1.41.41.4-1.51.5-0.40.51.51.61.51.51.51.0
Locomotion velocity, session 20.50.61.50.1-0.90.91.0-0.90.90.71.20.90.20.80.80.6-0.0
Locomotion distance, session 21.92.63.71.7-1.91.91.8-1.91.90.50.91.81.31.61.61.41.7
Locomotion velocity, session 30.20.31.20.00.5-0.5-0.50.4-0.4-1.1-0.4-0.40.3-0.3-0.30.2-0.9
Locomotion distance, session 32.22.43.51.6-1.71.71.7-1.71.7-0.31.01.51.61.91.91.80.6
Stereotopy head waving bouts, day 31.21.53.7-1.90.9-0.9-0.91.0-1.01.20.3-1.3-1.7-1.3-1.3-1.4-0.8
Stereotopy head waving duration, day 32.22.64.8-2.21.6-1.6-1.41.6-1.60.6-0.2-1.8-1.9-1.8-1.8-1.7-1.5
Locomotion velocity, session 76.67.29.72.9-3.13.13.0-3.13.10.41.42.92.32.82.82.62.7
Locomotion distance, session 76.68.310.93.0-3.23.33.2-3.33.3-0.11.83.22.73.23.23.21.7
Stereotopy head waving bouts, day 70.80.95.9-1.40.9-0.9-0.70.8-0.8-0.40.5-0.7-0.6-0.7-0.7-0.3-2.4
Stereotopy head waving duration, day 70.91.14.1-1.31.1-1.1-1.01.1-1.1-0.3-0.0-1.0-0.7-1.0-1.0-0.6-2.0
Locomotion velocity, session 81.72.08.6-1.4-1.21.21.4-1.11.02.92.60.6-1.50.60.6-0.2-0.3
Locomotion distance, session 85.68.213.01.9-3.63.63.5-3.43.42.52.62.71.02.82.81.92.9
Degree of sensitization distance0.30.31.6-0.4-0.60.60.6-0.50.51.30.90.4-0.50.00.0-0.10.3
Degree of sensitization stereotypy0.30.43.5-0.50.2-0.2-0.00.1-0.1-0.50.70.10.20.10.10.5-1.9
Conditioned locomotion0.50.61.2-0.60.5-0.5-0.60.6-0.60.9-0.4-1.0-1.0-1.0-1.0-1.10.7
Cocaine response after cond. corrected1.21.55.01.3-1.41.41.2-1.41.40.90.41.00.71.01.00.62.2
Cocaine response after cond. not corrected0.20.31.9-0.6-0.20.20.2-0.10.11.40.5-0.2-0.8-0.2-0.2-0.60.6
Cocaine response before conditioning5.66.712.4-3.52.7-2.7-2.42.7-2.80.4-0.3-2.5-2.8-2.6-2.6-2.5-3.2
Saline control response4.15.58.8-1.03.0-2.9-2.92.8-2.8-2.5-2.7-2.3-0.4-2.1-2.1-1.4-2.1
Bone: connectivity density1.52.34.82.2-1.61.61.4-1.61.6-0.3-0.01.61.71.41.41.42.1
Bone: cortical apparent density0.60.93.30.70.9-0.9-1.10.9-0.8-1.6-1.8-0.70.7-0.6-0.6-0.20.3
Bone: cortical area0.10.20.5-0.70.4-0.4-0.40.4-0.40.40.1-0.4-0.5-0.3-0.3-0.5-0.4
Bone: cortical porosity1.21.39.3-1.71.0-1.0-0.70.9-0.9-0.50.7-0.6-0.7-0.6-0.6-0.2-3.0
Bone: cortical porosity1.21.38.0-1.90.8-0.8-0.50.8-0.80.11.0-0.5-1.1-0.6-0.6-0.4-2.8
Bone: cortical thickness0.30.52.80.80.6-0.6-0.70.5-0.4-1.7-1.2-0.11.1-0.0-0.00.3-0.2
Bone: cortical thickness0.80.93.90.90.9-0.8-1.00.7-0.7-2.0-1.7-0.31.1-0.3-0.30.1-0.0
Bone: cortical tissue density0.60.93.00.61.0-0.9-1.10.9-0.9-1.5-1.7-0.70.6-0.7-0.7-0.30.2
Condit. Reinf. active minus inactive responses0.40.50.80.1-0.50.50.7-0.60.6-0.30.90.80.60.70.70.9-0.9
Condit. Reinf. active-inactive response ratio0.30.31.2-0.30.6-0.6-0.60.6-0.5-1.0-0.3-0.30.2-0.3-0.30.1-1.1
Condit. Reinf. active responses0.80.91.61.0-1.01.01.1-1.01.0-0.50.61.11.11.01.01.30.1
Condit. Reinf. inactive responses2.53.15.92.4-1.81.81.7-1.81.8-0.90.31.92.21.81.82.01.4
Incentive salience index mean1.92.33.80.6-1.91.92.0-1.81.81.11.91.70.61.61.61.30.4
Condit. Reinf. lever presses3.95.48.71.2-3.02.92.9-2.82.82.42.42.30.52.22.21.42.2
Condit. Reinf. active minus inactive responses1.52.03.0-1.71.5-1.5-1.31.5-1.50.1-0.4-1.4-1.5-1.7-1.7-1.3-1.5
Condit. Reinf. active-inactive response ratio2.12.55.0-2.21.5-1.5-1.31.5-1.50.8-0.0-1.6-2.1-1.8-1.8-1.7-1.5
Condit. Reinf. active responses0.50.61.0-0.80.9-0.9-0.80.9-0.9-0.3-0.3-0.8-0.7-1.0-1.0-0.6-1.0
Condit. Reinf. inactive responses0.10.21.00.60.2-0.1-0.20.1-0.1-1.0-0.60.10.80.10.10.4-0.0
Condit. Reinf. lever presses0.10.11.0-0.10.1-0.10.10.0-0.0-0.40.30.00.1-0.1-0.10.3-1.0
Condit. Reinf. lever reinforcers received0.40.51.5-0.90.7-0.7-0.60.7-0.7-0.2-0.0-0.7-0.6-0.8-0.8-0.5-1.2
Conditioned reinforcement - actives0.10.20.50.30.2-0.2-0.20.2-0.2-0.6-0.6-0.10.20.70.70.00.1
Conditioned reinforcement - inactives0.10.20.4-0.10.6-0.6-0.50.6-0.6-0.6-0.6-0.5-0.20.20.2-0.3-0.2
Conditioned locomotion0.10.10.5-0.20.1-0.2-0.10.2-0.20.1-0.2-0.3-0.40.70.7-0.3-0.1
Patch foraging indifference point 0 sec1.73.14.9-0.62.2-2.2-2.22.1-2.1-1.9-2.2-1.6-0.3-1.8-1.8-1.1-1.2
Patch foraging indifference point AUC0.30.43.2-1.00.5-0.5-0.40.5-0.5-0.00.5-0.4-0.4-0.4-0.4-0.2-1.8
Delay disc. indifference point, 0s delay0.20.21.2-0.4-0.50.40.5-0.40.41.10.80.0-0.50.10.1-0.10.2
Delay disc. indifference point, 16s delay0.20.20.80.00.4-0.4-0.40.4-0.4-0.9-0.4-0.10.3-0.1-0.10.2-0.7
Delay disc. indifference point, 2s delay1.11.33.9-2.00.8-0.8-0.60.9-0.91.00.7-1.0-1.7-1.1-1.1-1.2-1.3
Delay disc. indifference point, 24s delay1.11.24.6-1.21.1-1.1-1.01.1-1.1-0.4-0.2-1.1-0.8-1.0-1.0-0.6-2.1
Delay disc. indifference point, 4s delay1.41.43.0-1.71.3-1.3-1.21.3-1.30.2-0.1-1.3-1.3-1.1-1.1-1.2-1.3
Delay disc. indifference point, 8s delay0.10.10.4-0.2-0.20.20.2-0.20.20.10.50.30.10.40.40.3-0.6
Indifference point function ln k0.20.41.5-0.4-0.60.60.7-0.60.61.01.20.5-0.30.50.50.2-0.2
Indifference point function log k0.20.41.5-0.4-0.60.60.7-0.60.61.01.20.5-0.30.50.50.2-0.2
Patch foraging total patch changes 0 sec1.73.25.1-0.62.3-2.2-2.32.1-2.1-2.0-2.2-1.6-0.2-1.8-1.8-1.1-1.2
Patch foraging total patch changes 12 sec1.51.92.9-0.51.7-1.7-1.71.6-1.6-1.6-1.5-1.4-0.1-1.3-1.3-0.7-1.5
Patch foraging total patch changes 18 sec0.91.46.11.31.0-1.0-1.20.8-0.8-2.5-2.2-0.31.4-0.5-0.50.30.1
Patch foraging total patch changes 24 sec0.61.14.91.70.0-0.0-0.2-0.10.1-2.2-1.30.41.80.50.51.10.2
Patch foraging total patch changes 6 sec1.42.24.2-0.11.8-1.8-1.81.7-1.7-2.0-2.0-1.30.1-1.3-1.3-0.7-1.0
Patch foraging time to switch 0 sec0.40.85.91.5-0.10.1-0.2-0.00.0-0.5-1.6-0.10.7-0.2-0.2-0.22.4
Patch foraging water rate 0 sec0.20.30.5-0.70.6-0.6-0.60.6-0.60.1-0.3-0.6-0.6-0.7-0.7-0.6-0.6
Patch foraging water rate 12 sec0.20.51.40.9-0.30.30.2-0.40.4-1.0-0.30.81.20.70.70.90.2
Patch foraging water rate 18 sec0.20.20.4-0.20.6-0.6-0.70.6-0.6-0.5-0.7-0.6-0.1-0.3-0.3-0.3-0.1
Patch foraging water rate 24 sec0.10.10.50.10.4-0.4-0.40.3-0.3-0.7-0.50.00.3-0.1-0.10.00.0
Patch foraging water rate 6 sec0.10.10.40.40.0-0.0-0.1-0.00.0-0.6-0.30.40.60.30.30.30.1
Seeking ratio, delayed vs. immediate footshock1.01.23.2-1.21.3-1.3-1.31.2-1.2-0.8-0.2-0.8-0.3-1.0-1.0-0.5-1.8
Distance traveled before self-admin0.20.21.90.1-0.20.2-0.0-0.10.10.8-0.2-0.3-0.40.40.4-0.51.4
Distance traveled after self-admin1.31.62.4-1.51.4-1.5-1.51.5-1.50.2-0.6-1.5-1.3-1.0-1.0-1.5-0.8
Extensor digitorum longus weight0.10.41.7-0.80.1-0.1-0.00.2-0.21.30.3-0.4-1.2-0.5-0.5-0.90.4
Bone: elastic displacement0.20.21.40.30.3-0.3-0.20.2-0.2-1.2-0.4-0.10.6-0.0-0.00.5-0.9
Bone: elastic work0.20.30.4-0.40.6-0.6-0.60.6-0.6-0.4-0.4-0.5-0.2-0.7-0.7-0.4-0.6
Bone: endosteal estimation3.57.717.9-4.12.2-2.2-2.02.4-2.42.80.2-3.0-4.2-2.9-2.9-3.6-1.2
Bone: endosteal perimeter1.12.39.3-2.50.2-0.3-0.10.4-0.53.11.4-1.0-2.7-1.0-1.0-1.9-0.1
Epididymis fat weight2.37.930.73.12.3-2.2-2.72.0-2.0-5.1-5.5-1.42.8-1.4-1.4-0.12.4
Delta time in closed arm before/after self-admin0.60.61.1-0.50.6-0.6-0.60.7-0.70.5-0.6-0.8-0.9-1.0-1.0-1.00.6
Delta time in open arm before/after self-admin0.20.20.70.10.4-0.4-0.40.4-0.4-0.8-0.5-0.20.20.50.50.1-0.3
Diff in mean of infusions in LGA sessions3.84.76.32.0-2.52.52.3-2.52.50.61.42.51.82.52.52.01.9
Delay discount exponential model param0.40.41.61.1-0.60.60.5-0.60.6-0.1-0.30.50.70.40.40.41.3
Extinction: sum of active levers before priming0.40.41.4-0.2-0.70.70.8-0.70.71.21.00.5-0.40.00.00.10.5
Active lever presses in extinction session 60.10.10.50.60.1-0.1-0.00.0-0.0-0.7-0.50.10.40.00.00.20.5
Bone: final force1.11.73.4-0.41.5-1.5-1.71.5-1.5-0.6-1.8-1.5-0.5-1.4-1.4-1.40.3
Bone: final moment1.11.73.1-0.41.5-1.5-1.61.5-1.5-0.6-1.8-1.5-0.6-1.4-1.4-1.30.2
Food consumed during 24 hour testing period0.30.41.5-0.50.1-0.2-0.30.3-0.31.2-0.2-0.7-1.0-0.4-0.4-1.11.2
Glucose1.62.512.8-2.0-1.01.01.3-0.80.83.62.60.0-2.40.20.2-0.9-0.2
Heart weight3.24.97.5-2.72.4-2.4-2.22.4-2.40.3-0.8-2.4-2.4-2.4-2.4-2.3-2.0
Delay discount hyperbolic model param0.50.62.11.3-0.70.70.6-0.70.7-0.2-0.40.60.80.50.50.51.4
Intermittent access intake day 1-15 change0.00.10.60.00.1-0.1-0.10.0-0.0-0.40.10.20.30.40.40.3-0.8
Intermittent access intake escalation0.20.41.80.20.5-0.5-0.50.4-0.4-1.3-0.40.10.80.30.30.4-1.3
Intermittent access intake escalation 20.10.10.7-0.2-0.10.10.1-0.10.1-0.10.50.30.1-0.1-0.10.3-0.8
Intermitt. access day 1 inactive lever presses0.20.84.2-1.0-0.40.30.4-0.20.22.11.0-0.3-1.3-0.5-0.5-0.80.9
Intermitt. access day 15 inactive lever presses0.40.71.4-0.80.8-0.8-0.80.9-0.90.3-0.5-1.1-0.9-1.2-1.2-1.0-0.0
Intermitt. access escalation Index2.33.34.71.2-2.12.12.0-2.12.11.01.61.91.12.22.21.41.5
Intermittent access day 1 total infusions0.81.34.51.1-0.90.91.0-1.01.0-0.40.41.00.92.12.11.10.4
Intermittent access day 15 total infusions0.50.72.30.8-0.10.10.2-0.20.2-1.3-0.20.61.11.51.50.9-0.7
Intermittent access terminal intake (last 3 days)0.30.41.20.10.5-0.4-0.30.4-0.4-1.1-0.4-0.10.30.90.90.3-1.0
Intermittent access total infusions0.40.52.40.40.1-0.10.00.0-0.0-1.0-0.30.20.51.61.60.5-0.6
Intermittent access day 1 locomotion0.40.52.00.9-0.20.20.2-0.20.2-0.6-0.50.30.61.41.40.40.4
Intermittent access day 15 total locomotion0.20.40.8-0.30.8-0.8-0.90.8-0.8-0.4-0.9-0.6-0.30.60.6-0.6-0.4
Intermittent access total locomotion0.30.30.80.20.6-0.6-0.60.5-0.5-0.9-0.9-0.30.20.70.7-0.1-0.4
Intermittent access standard deviation1.22.44.2-0.82.0-2.0-2.12.0-2.0-1.2-2.0-1.8-0.6-1.0-1.0-1.3-0.8
Left kidney weight2.511.717.2-2.34.0-4.0-4.14.0-4.0-1.0-3.5-4.1-2.4-3.8-3.8-3.6-0.8
Right kidney weight2.210.115.0-2.03.6-3.6-3.83.7-3.7-0.6-3.4-3.9-2.3-3.5-3.5-3.5-0.2
Cocaine induced anxiety0.30.40.90.0-0.60.60.5-0.60.51.00.60.3-0.10.90.9-0.00.9
Post-drug Anxiety0.20.20.4-0.50.3-0.3-0.30.3-0.30.5-0.0-0.5-0.6-0.4-0.4-0.60.4
Baseline Anxiety0.40.51.8-0.50.6-0.6-0.60.6-0.6-0.2-0.4-0.6-0.4-1.4-1.4-0.5-0.5
Tail length3.011.923.7-4.93.4-3.4-3.13.5-3.51.6-0.3-3.7-4.4-3.5-3.5-3.9-3.2
Length with tail3.214.123.8-4.93.6-3.7-3.43.8-3.82.1-1.0-4.3-4.9-4.0-4.0-4.6-2.1
Length without tail2.37.514.8-2.62.4-2.4-2.52.6-2.62.0-1.8-3.5-3.4-3.1-3.1-3.81.0
Times rat made contact with spout1.11.34.41.3-0.40.40.4-0.50.6-2.1-0.01.12.00.90.91.7-1.0
Lifetime Intake0.40.42.30.30.2-0.2-0.10.1-0.1-0.8-0.30.00.31.51.50.3-0.5
Liver weight, left1.32.16.3-2.10.8-0.8-0.81.0-1.02.20.3-1.6-2.5-1.1-1.1-2.10.1
Liver weight, right1.42.57.5-2.40.7-0.7-0.50.9-0.92.60.8-1.6-2.7-1.4-1.4-2.1-0.2
Locomotor activity1.52.45.1-2.31.5-1.5-1.41.5-1.50.50.1-1.7-1.8-1.6-1.6-1.5-1.9
Locomotor testing distance0.61.12.2-1.50.9-0.9-0.81.0-1.00.70.0-1.3-1.4-1.1-1.1-1.2-0.8
Locomotor testing rearing0.61.32.3-1.21.1-1.1-1.11.1-1.10.7-0.6-1.4-1.5-1.3-1.3-1.50.1
Locomotion in novel chamber0.00.00.10.00.1-0.1-0.20.1-0.1-0.3-0.1-0.10.2-0.1-0.10.00.1
Locomotion in novel chamber post-restriction0.91.52.2-0.61.4-1.4-1.51.4-1.4-0.5-1.5-1.2-0.7-1.4-1.4-1.2-0.1
Fecal boli incidents, locomotor time 10.20.33.20.6-0.00.00.10.0-0.0-0.1-0.70.10.0-0.3-0.3-0.21.8
Change in fecal boli incidents, locomotor task0.70.72.4-1.50.2-0.2-0.20.3-0.31.60.8-0.6-1.4-0.5-0.5-1.0-0.8
Time >=10cm from walls, locomotor time 11.71.74.1-1.30.9-1.0-1.11.1-1.11.5-0.7-1.4-1.8-1.3-1.3-2.01.3
Bouts of movement, locomotor time 10.80.91.20.6-1.01.01.0-1.11.10.10.91.00.91.11.11.1-0.4
Total resting periods, locomotor time 10.50.60.80.4-0.90.90.9-0.90.90.30.90.80.60.90.90.8-0.4
Rest time, locomotor task time 10.20.20.7-0.80.3-0.3-0.20.3-0.30.60.3-0.5-0.8-0.6-0.6-0.6-0.2
Distance moved, locomotor task time 10.10.10.3-0.20.4-0.4-0.50.4-0.4-0.3-0.5-0.3-0.1-0.3-0.3-0.3-0.3
Vertical activity count, locomotor time 10.10.30.90.10.6-0.6-0.80.6-0.6-0.7-0.9-0.20.2-0.3-0.3-0.3-0.2
Time >=10cm from walls, locomotor time 21.31.94.3-1.81.2-1.2-1.21.3-1.31.3-0.4-1.4-2.1-1.4-1.4-1.90.0
Bouts of movement, locomotor time 20.20.32.0-0.90.4-0.4-0.30.4-0.4-0.10.6-0.4-0.3-0.2-0.2-0.1-1.4
Total resting periods, locomotor time 20.20.42.9-1.20.3-0.3-0.10.2-0.20.31.0-0.4-0.5-0.1-0.1-0.1-1.7
Rest time, locomotor task time 20.60.83.6-0.3-1.00.90.9-0.80.81.91.20.3-0.70.40.4-0.21.0
Distance moved, locomotor task time 20.60.72.40.20.9-0.9-1.00.9-0.9-1.0-1.5-0.70.0-0.8-0.8-0.4-0.0
Vertical activity count, locomotor time 20.50.61.5-0.20.9-0.9-1.00.9-0.9-0.5-1.2-0.9-0.3-0.8-0.8-0.70.1
Light reinforcement 10.10.21.70.7-0.10.1-0.2-0.00.00.0-0.8-0.00.3-0.0-0.0-0.21.3
Light reinforcement 20.20.21.80.1-0.10.1-0.1-0.00.00.8-0.4-0.4-0.4-0.2-0.2-0.61.4
Bone: marrow area3.88.218.3-4.12.4-2.4-2.22.6-2.62.70.0-3.2-4.3-3.0-3.0-3.7-1.3
Bone: maximum diameter0.61.15.7-1.5-0.50.50.6-0.40.32.41.7-0.1-1.6-0.1-0.1-0.7-0.2
Bone: maximum force0.71.32.0-0.51.3-1.3-1.41.3-1.3-0.2-1.4-1.3-0.7-1.3-1.3-1.30.3
Bone: maximum moment0.81.31.9-0.71.3-1.3-1.31.3-1.3-0.2-1.3-1.4-0.9-1.3-1.3-1.30.1
Mean time between licks in bursts0.51.14.7-1.0-1.00.91.1-0.90.82.22.00.6-1.10.40.4-0.1-0.2
Mean num. licks in bursts0.81.27.31.30.8-0.7-0.80.6-0.6-2.7-1.7-0.21.5-0.1-0.10.7-0.5
Cd content in liver0.60.63.61.5-0.40.40.2-0.40.4-0.5-1.10.10.80.20.20.31.9
Co content in liver1.11.23.20.01.2-1.2-1.31.2-1.2-0.8-1.8-1.1-0.2-1.3-1.3-1.00.5
Cu content in liver1.41.75.01.7-0.80.80.8-0.91.0-1.90.11.22.21.31.31.9-0.2
Fe content in liver0.60.72.40.40.9-0.9-1.00.8-0.8-1.2-1.5-0.60.3-0.6-0.6-0.40.4
K content in liver1.21.11.61.0-1.21.21.2-1.21.20.20.71.20.91.11.11.00.8
Mg content in liver2.02.04.20.1-1.71.71.8-1.61.62.02.01.3-0.21.21.20.70.8
Mn content in liver1.51.77.9-0.7-1.31.31.3-1.11.12.81.90.7-1.20.60.6-0.31.1
Na content in liver0.50.51.20.5-0.40.40.3-0.50.5-0.80.40.71.10.90.91.0-0.8
Rb content in liver0.50.51.90.9-0.80.80.7-0.80.80.50.10.40.40.70.70.41.4
Se content in liver1.41.67.6-1.4-1.11.01.3-1.01.02.12.80.4-1.00.50.50.2-1.1
Sr content in liver0.60.51.1-0.80.7-0.7-0.70.7-0.70.5-0.4-0.6-1.1-0.8-0.8-1.00.1
Zn content in liver0.10.10.6-0.1-0.30.20.3-0.20.20.80.30.0-0.5-0.1-0.1-0.30.5
Bone: minimum diameter0.91.66.2-2.00.3-0.3-0.20.5-0.52.50.9-1.0-2.3-0.8-0.8-1.7-0.0
Time in familiar zone, hab. session 12.01.95.72.0-0.70.70.6-0.80.9-2.3-0.41.42.41.41.42.0-0.1
Time in novel zone, hab. session 12.32.35.5-2.11.2-1.2-1.11.3-1.31.7-0.0-1.6-2.3-1.5-1.5-2.1-0.4
Total zone transitions, hab. session 10.50.71.10.6-1.01.01.0-1.01.00.30.81.00.61.01.00.80.4
Total locomotion distance, hab. session 10.71.01.41.0-1.21.21.1-1.11.10.30.61.20.71.11.10.81.0
Locomotion velocity, hab. session 10.40.50.80.6-0.80.80.8-0.80.80.20.60.90.50.80.80.60.5
Time in familiar zone, hab. session 20.30.31.70.70.2-0.2-0.30.1-0.1-1.3-0.60.21.10.40.40.6-0.2
Time in novel zone, hab. session 20.40.40.8-0.80.6-0.6-0.50.6-0.60.3-0.2-0.7-0.9-0.8-0.8-0.7-0.5
Total zone transitions, hab. session 20.40.61.40.9-0.80.80.7-0.80.80.20.10.80.70.60.60.51.2
Total locomotion distance, hab. session 22.02.64.51.8-1.81.81.6-1.81.80.40.61.81.41.71.71.32.1
Locomotion velocity, hab. session 22.53.34.61.8-2.12.11.9-2.12.10.71.02.01.41.91.91.52.1
Novel to familiar place preference ratio0.10.10.20.0-0.20.30.3-0.30.3-0.10.40.40.20.20.20.4-0.4
Novelty place preference0.10.10.5-0.3-0.00.00.1-0.10.1-0.00.50.2-0.00.10.10.2-0.7
Time in novel zone, NPP test0.10.11.0-0.50.2-0.2-0.10.2-0.2-0.00.4-0.0-0.2-0.1-0.10.0-1.0
Total zone transitions, NPP test1.72.43.51.6-1.91.91.8-1.81.80.50.91.71.21.61.61.41.5
Total locomotion distance, NPP test2.12.96.42.2-1.91.91.8-1.91.90.40.31.61.41.61.61.32.5
Locomotion velocity, NPP test3.24.58.72.6-2.42.42.2-2.42.40.50.62.11.72.12.11.72.9
Intraocular pressure0.50.72.21.5-0.40.40.2-0.40.5-1.1-0.80.71.30.70.70.90.7
Delta distance traveled before/after self-admin2.93.06.8-2.12.0-2.0-1.81.9-1.9-0.6-0.5-1.6-1.4-1.7-1.7-1.3-2.6
Delta ambulatory time before/after self-admin1.92.46.1-2.01.7-1.7-1.51.6-1.6-0.2-0.2-1.4-1.3-1.5-1.5-1.2-2.5
Parametrial fat weight0.71.66.61.01.0-1.0-1.41.0-1.0-1.2-2.6-1.20.5-0.9-0.9-0.81.9
Pavlov. Cond. lever latency3.24.09.70.12.4-2.3-2.62.3-2.2-2.3-3.1-1.90.2-1.9-1.9-1.30.1
Pavlov. Cond. magazine entry latency1.41.76.6-0.7-1.31.21.5-1.31.21.32.61.2-0.21.11.10.9-1.5
Pavlov. Cond. change in total contacts0.70.73.2-0.8-0.70.70.9-0.70.61.01.80.5-0.50.60.60.4-1.2
Pavlov. Cond. index score2.73.510.0-0.4-2.12.12.3-2.02.02.23.21.8-0.21.81.81.2-0.6
Pavlov. Cond. latency score3.03.710.8-0.4-2.22.22.4-2.12.12.33.31.9-0.21.81.81.2-0.6
Pavlov. Cond. lever contacts3.03.57.7-0.0-2.32.32.4-2.22.12.62.81.7-0.41.71.70.90.5
Pavlov. Cond. magazine entry number0.91.14.20.51.0-1.0-1.31.0-1.0-1.1-2.1-1.00.2-0.9-0.9-0.81.1
Pavlov. Cond. intertrial magazine entries0.70.82.71.70.1-0.1-0.30.1-0.1-1.6-1.6-0.11.30.00.00.51.3
Pavlov. Cond. lever-magazine prob. diff.2.83.59.6-0.3-2.12.12.4-2.12.12.03.11.8-0.11.81.81.3-0.5
Pavlov. Cond. response bias1.82.36.7-0.3-1.71.71.9-1.61.61.82.61.4-0.21.31.30.9-0.5
Pavlov. Cond. lever latency0.20.31.6-0.4-0.30.30.2-0.20.21.30.3-0.1-0.70.10.1-0.60.9
Pavlov. Cond. magazine entry latency0.10.10.3-0.2-0.30.30.4-0.30.30.40.50.2-0.2-0.0-0.00.1-0.2
Pavlov. Cond. change in total contacts0.30.52.1-0.50.7-0.7-0.60.7-0.7-0.8-0.2-0.4-0.1-0.6-0.6-0.0-1.4
Pavlov. Cond. index score0.10.10.8-0.20.2-0.2-0.10.2-0.1-0.40.1-0.1-0.0-0.3-0.30.2-0.9
Pavlov. Cond. latency score0.10.20.9-0.30.4-0.4-0.30.3-0.3-0.5-0.1-0.2-0.1-0.4-0.40.1-0.9
Pavlov. Cond. lever contacts0.20.21.30.30.3-0.3-0.30.2-0.2-1.1-0.4-0.00.5-0.2-0.20.4-0.8
Pavlov. Cond. magazine entry number0.00.00.0-0.20.2-0.2-0.20.2-0.2-0.1-0.0-0.2-0.1-0.0-0.0-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.40.62.3-0.4-0.80.80.9-0.80.81.01.50.6-0.10.70.70.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.10.2-0.2-0.10.1-0.1-0.40.1-0.00.0-0.2-0.20.2-0.8
Pavlov. Cond. response bias0.10.10.40.3-0.20.30.3-0.30.3-0.50.30.40.50.20.20.6-0.6
Time in closed arm before self-admin0.20.20.5-0.70.3-0.3-0.20.3-0.30.50.1-0.6-0.7-0.5-0.5-0.5-0.4
Time in closed arm after self-admin0.20.20.6-0.20.2-0.2-0.20.3-0.30.2-0.2-0.5-0.4-0.8-0.8-0.50.4
Time in open arm before self-admin0.40.41.1-0.2-0.50.50.7-0.60.60.11.10.60.20.70.70.7-1.0
Time in open arm after self-admin0.20.21.0-0.50.4-0.4-0.30.4-0.4-0.40.1-0.1-0.20.80.8-0.0-1.0
Bone: periosteal estimation2.24.59.4-3.11.8-1.9-1.72.0-2.01.8-0.1-2.4-3.0-2.2-2.2-2.7-1.1
Bone: periosteal perimeter0.61.13.5-1.90.4-0.4-0.30.5-0.51.80.9-0.7-1.8-0.7-0.7-1.3-0.7
Bone: post-yield work0.50.73.7-1.00.0-0.0-0.00.2-0.21.90.4-0.6-1.6-0.5-0.5-1.20.8
Progressive ratio test 1 active lever presses0.10.10.80.10.0-0.00.00.1-0.1-0.1-0.2-0.1-0.10.90.9-0.00.0
Progressive ratio test 1 breakpoint0.10.10.6-0.00.1-0.1-0.00.1-0.1-0.0-0.2-0.2-0.20.80.8-0.1-0.0
Progressive ratio test 1 inactive lever presses0.30.41.31.1-0.10.10.0-0.10.2-0.7-0.80.30.70.70.70.31.1
Progressive ratio test 2 active lever presses0.80.92.91.0-0.70.70.7-0.80.8-0.60.21.01.11.71.71.00.2
Progressive ratio test 2 breakpoint0.91.02.91.1-0.70.70.7-0.70.8-0.80.21.01.21.71.71.10.1
Progressive ratio test 2 inactive lever presses0.20.31.0-0.1-0.40.40.5-0.40.40.70.50.1-0.41.01.0-0.00.4
Incentive Sensitization - Responses0.60.91.40.7-0.90.90.9-0.91.0-0.30.81.21.01.21.21.1-0.1
Incentive Sensitization - Breakpoint0.81.11.81.0-1.01.01.0-1.01.0-0.40.71.31.21.41.41.30.1
Sum of active levers in priming session hrs 5-60.20.20.5-0.60.1-0.10.00.2-0.20.30.4-0.1-0.6-0.7-0.7-0.2-0.7
Progressive ratio3.25.18.4-1.32.8-2.8-2.92.7-2.7-1.3-2.4-2.5-1.0-2.4-2.4-2.0-0.9
Food seeking constrained by brief footshock0.10.10.60.00.4-0.4-0.40.4-0.4-0.8-0.4-0.20.20.20.20.1-0.4
Seeking ratio, punishment vs. effort1.92.84.50.6-2.02.02.1-1.91.91.02.11.80.61.91.91.6-0.1
Retroperitoneal fat weight0.10.43.11.1-0.10.1-0.1-0.10.1-0.4-1.0-0.30.6-0.0-0.0-0.01.8
Reaction time number correct0.91.74.20.01.6-1.6-1.71.5-1.5-1.6-2.0-1.20.1-1.0-1.0-0.8-0.2
Reaction time mean minus median0.82.03.60.3-1.71.71.8-1.71.61.41.91.20.21.61.61.00.4
Reaction time mean minus median AUC0.92.33.90.7-1.91.92.0-1.81.81.31.81.30.31.61.61.10.7
Reaction time num false alarms0.20.31.4-0.6-0.40.40.5-0.40.40.81.20.4-0.30.30.30.1-0.5
Reaction time num false alarms AUC0.30.41.7-1.1-0.10.10.2-0.10.10.91.30.2-0.60.00.0-0.1-1.2
Reaction time trials correct on left0.91.74.20.01.6-1.6-1.71.5-1.5-1.6-2.0-1.20.1-1.0-1.0-0.8-0.2
Reaction time trials on left0.91.74.1-0.01.6-1.6-1.71.5-1.5-1.6-2.0-1.2-0.0-1.1-1.1-0.8-0.2
Reaction time mean1.62.65.30.4-2.02.02.0-1.91.92.31.91.2-0.31.41.40.61.4
Reaction time mean AUC1.52.44.60.4-2.02.02.0-1.91.82.21.81.2-0.21.31.30.71.4
Median of all reaction times1.21.74.40.3-1.71.61.6-1.51.52.11.40.9-0.40.90.90.31.5
Reaction time omissions0.91.33.00.2-1.41.41.4-1.31.31.71.51.0-0.20.90.90.41.1
Reaction time false alarm rate0.91.35.7-1.1-1.00.91.1-0.90.91.82.40.8-0.70.60.60.3-1.1
Reaction time premature initiation rate0.60.81.4-0.60.8-0.8-0.90.9-0.90.2-0.8-1.1-1.0-1.2-1.2-1.00.2
Reaction time premature initiations1.42.53.9-0.71.8-1.8-1.91.8-1.8-0.7-2.0-1.9-1.0-1.8-1.8-1.5-0.1
Std. dev. reaction times1.01.85.2-0.4-1.61.51.7-1.51.52.02.30.9-0.51.21.20.6-0.1
Reaction time trials completed0.91.74.1-0.01.6-1.6-1.71.5-1.5-1.6-2.0-1.2-0.0-1.1-1.1-0.8-0.2
Reaction time trials AUC0.81.54.00.11.5-1.5-1.61.4-1.4-1.5-2.0-1.10.1-1.0-1.0-0.7-0.1
Run reversals in cocaine runway, females0.20.20.90.60.3-0.3-0.40.3-0.3-0.9-1.0-0.20.4-0.0-0.00.00.8
Run reversals in cocaine runway, males0.30.30.8-0.2-0.60.60.6-0.50.50.90.80.3-0.40.40.40.1-0.0
Latency to leave start box in cocaine runway0.91.02.00.2-1.21.21.2-1.21.11.41.30.8-0.10.30.30.41.4
Latency to leave start box in cocaine runway, F0.80.92.00.4-1.21.21.2-1.11.11.01.10.90.20.50.50.51.4
Latency to leave start box in cocaine runway, M0.20.10.7-0.2-0.30.30.3-0.30.30.80.40.1-0.3-0.4-0.4-0.20.5
Std. dev. time between licks in bursts1.21.67.7-2.0-0.30.30.5-0.20.12.81.8-0.3-2.1-0.6-0.6-1.1-0.5
Total sessions with >9 infusions0.30.41.4-0.30.5-0.5-0.30.4-0.4-0.7-0.2-0.2-0.01.11.10.1-1.2
Short access day 1 total inactive lever presses0.20.31.3-0.80.0-0.00.10.1-0.11.00.5-0.5-1.1-0.1-0.1-0.6-0.0
Short access day 10 total inactive lever presses0.51.21.70.8-1.21.21.1-1.21.20.70.91.10.71.31.30.71.3
Short access day 1 total infusions0.20.31.6-0.2-0.00.00.2-0.00.00.10.3-0.0-0.31.31.30.1-0.6
Short access day 10 total infusions0.40.51.90.7-0.20.20.3-0.30.3-0.8-0.20.40.71.41.40.7-0.0
Short access total infusions0.20.31.80.20.0-0.00.10.0-0.0-0.5-0.10.00.11.41.40.2-0.4
Short access day 1 locomotion1.62.05.90.9-1.41.41.3-1.41.40.41.11.40.92.42.41.20.2
Short access day 10 total locomotion1.22.25.0-2.21.4-1.5-1.41.5-1.51.1-0.1-1.7-2.1-0.8-0.8-1.9-1.3
Short access total locomotion0.30.30.9-0.80.3-0.3-0.30.3-0.30.80.1-0.5-0.90.70.7-0.7-0.3
One hour access (0.3 mA shock)2.93.35.01.6-1.92.01.9-2.02.0-0.01.42.21.82.22.22.00.7
Compulsive drug intake2.93.55.70.7-2.42.42.2-2.32.32.32.21.80.41.21.20.92.1
One hour access (shock baseline)0.40.73.41.00.2-0.2-0.20.1-0.1-1.8-0.80.41.20.90.90.9-0.7
Social response proportion1.41.63.3-1.71.1-1.1-1.01.2-1.21.0-0.2-1.3-1.8-1.4-1.4-1.7-0.4
Social responses1.11.42.9-1.71.1-1.2-1.01.2-1.20.6-0.0-1.2-1.5-1.3-1.3-1.4-0.9
Social time1.21.65.6-0.5-1.41.41.4-1.31.32.42.10.8-0.60.80.80.10.8
Soleus weight1.23.518.2-2.8-0.20.10.30.1-0.14.31.9-0.7-3.4-1.0-1.0-2.10.4
Bone: stiffness0.20.31.30.40.5-0.5-0.70.5-0.5-0.6-1.1-0.40.3-0.3-0.3-0.40.7
Tibialis anterior weight0.10.41.70.80.4-0.4-0.50.3-0.3-1.3-1.0-0.20.8-0.3-0.30.20.2
Time to tail flick, vehicle, before self-admin2.02.03.01.6-1.61.61.3-1.61.60.10.71.71.61.51.51.41.2
Time to tail flick, vehicle, after self-admin0.40.51.2-0.0-0.80.80.9-0.80.80.71.10.50.01.01.00.5-0.2
Time to tail flick, test, before self-admin0.30.30.90.4-0.20.20.1-0.30.3-0.90.20.71.00.50.50.8-0.7
Time to tail flick, test, after self-admin1.41.52.91.3-1.31.31.4-1.41.4-0.61.01.51.50.70.71.7-0.0
Delta time to tail flick, vehicle, before/after SA0.10.10.20.2-0.20.20.4-0.20.3-0.30.20.20.20.40.40.5-0.4
Delta time to tail flick, test, before/after SA0.60.71.91.3-0.90.90.8-0.90.9-0.2-0.10.70.90.30.30.71.4
Tibia length2.26.113.3-3.22.1-2.1-2.02.3-2.32.2-0.5-3.0-3.6-2.5-2.5-3.4-0.5
Ambulatory time before self-admin0.10.20.90.3-0.30.30.2-0.30.30.3-0.00.10.10.60.60.00.9
Ambulatory time after self-admin1.31.62.4-1.61.4-1.4-1.31.4-1.40.2-0.5-1.5-1.3-1.1-1.1-1.4-1.0
Bone: tissue strength0.30.30.60.00.4-0.4-0.40.5-0.5-0.0-0.8-0.6-0.4-0.7-0.7-0.60.6
Total heroin consumption0.00.00.2-0.3-0.10.00.1-0.00.00.30.4-0.1-0.2-0.0-0.0-0.1-0.0
Bone: trabecular number2.74.510.03.2-2.02.01.8-2.12.1-1.3-0.12.42.82.12.12.41.9
Bone: trabecular spacing3.44.58.7-3.02.1-2.1-1.92.1-2.21.2-0.3-2.5-2.7-2.1-2.1-2.5-1.8
Bone: trabecular thickness1.92.36.02.5-1.41.41.2-1.41.4-1.0-0.31.52.11.41.41.61.8
Bone: trabecular tissue density0.50.84.0-1.20.9-0.9-0.70.8-0.8-0.30.2-0.6-0.6-0.7-0.7-0.4-2.0
Water consumed over 24 hours0.10.10.7-0.5-0.20.20.3-0.20.20.80.60.0-0.5-0.1-0.1-0.2-0.0
Number of responses in last shaping day1.71.96.2-2.50.9-0.9-0.60.9-1.01.61.0-1.3-2.3-0.6-0.6-1.5-1.7