Hub : Genes

Lxn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Lxn 0.35 0.13 0.0e+00 0.18 0.22 0.22 0.22 7.8e-20 7.3e-24 7.6e-24 3.3e-24
2 pVTA gene expression Lxn 0.47 0.15 1.2e-10 0.19 0.2 0.22 0.19 1.0e-08 3.2e-09 7.7e-10 1.4e-08
3 PL gene expression Lxn 0.24 0.08 0.0e+00 0.26 0.24 0.24 0.24 2.3e-28 1.1e-26 1.8e-26 1.3e-26
4 RMTg gene expression Lxn 0.12 0.08 6.1e-03 0.06 0.02 0.01 0.04 1.1e-02 7.4e-02 2.2e-01 4.0e-02
5 Brain gene expression Lxn 0.34 0.1 0.0e+00 0.39 0.41 0.41 0.41 1.4e-38 8.0e-41 1.4e-40 1.2e-40
6 BLA gene expression Lxn 0.07 0.05 2.2e-03 0.03 0.01 0.02 0.02 7.6e-03 6.5e-02 2.1e-02 1.8e-02
7 OFC gene expression Lxn 0.27 0.15 1.1e-03 0.03 0.05 0.05 0.06 6.6e-02 3.0e-02 2.3e-02 1.7e-02
8 NAcc gene expression Lxn 0.13 0.06 1.1e-12 0.09 0.1 0.1 0.1 2.1e-10 1.6e-11 4.0e-12 9.9e-12
9 LHb gene expression Lxn 0.53 0.28 3.9e-07 0.37 0.3 0.37 0.32 1.3e-09 5.7e-08 8.5e-10 2.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.54.222.44.70.91.51.4-2.11.5-0.81.31.0
Area under the delay curve0.30.31.40.6-1.2-0.2-0.20.20.50.30.00.6
BMI with tail1.23.97.50.9-2.7-1.9-1.92.3-1.92.4-1.8-1.2
BMI without tail0.30.62.11.3-1.40.10.00.10.20.40.31.1
Body weight1.04.29.81.0-3.1-2.2-2.22.1-1.92.3-1.8-0.9
Weight adjusted by age0.70.83.51.9-1.5-0.5-0.40.2-0.20.8-0.30.4
Bone surface1.11.913.93.7-0.8-0.5-0.5-0.2-0.51.0-0.5-0.5
Bone volume1.32.217.44.20.10.40.4-1.10.40.10.30.1
Breakpoint value in progressive ratio session0.10.10.7-0.80.0-0.3-0.30.30.10.2-0.4-0.4
Number of licking bursts0.70.85.42.3-0.6-0.4-0.40.1-0.70.6-0.4-0.7
Context. condit. distance diff. score2.93.54.31.81.21.91.9-2.12.1-1.82.01.9
Locomotion velocity, session 10.10.10.2-0.40.50.20.3-0.30.5-0.50.30.1
Locomotion distance, session 10.81.01.4-1.1-0.6-1.2-1.10.9-0.80.8-1.0-1.1
Locomotion velocity, session 20.00.00.00.10.1-0.2-0.2-0.2-0.1-0.0-0.1-0.1
Locomotion distance, session 21.72.33.0-1.5-0.8-1.7-1.71.5-1.41.5-1.7-1.7
Locomotion velocity, session 31.11.32.81.3-0.4-1.1-1.10.8-1.01.1-1.3-1.7
Locomotion distance, session 30.50.64.12.00.40.30.3-0.60.5-0.00.2-0.2
Stereotopy head waving bouts, day 30.20.21.41.20.20.20.2-0.50.3-0.10.20.0
Stereotopy head waving duration, day 30.20.21.81.4-0.10.10.1-0.50.10.00.10.2
Locomotion velocity, session 70.20.31.8-1.30.3-0.3-0.20.2-0.10.2-0.2-0.3
Locomotion distance, session 71.51.92.9-1.01.71.51.5-1.21.5-1.41.31.0
Stereotopy head waving bouts, day 70.50.60.90.2-0.6-0.9-0.90.5-0.80.8-0.8-0.8
Stereotopy head waving duration, day 72.63.14.30.3-1.8-2.1-2.01.6-2.01.9-1.9-1.7
Locomotion velocity, session 80.50.61.00.1-0.9-1.0-0.90.8-0.80.7-0.8-0.7
Locomotion distance, session 80.10.10.4-0.60.2-0.4-0.30.2-0.00.2-0.4-0.6
Degree of sensitization distance1.51.57.8-2.80.90.90.8-0.30.8-1.00.81.0
Degree of sensitization stereotypy0.70.81.3-0.5-0.8-1.1-1.10.8-0.90.9-1.0-0.8
Conditioned locomotion0.40.50.80.6-0.9-0.8-0.70.6-0.80.7-0.6-0.5
Cocaine response after cond. corrected0.40.40.8-0.90.20.60.5-0.00.6-0.70.70.9
Cocaine response after cond. not corrected0.20.20.8-0.9-0.2-0.3-0.30.7-0.20.1-0.2-0.2
Cocaine response before conditioning0.70.81.81.0-0.3-0.9-0.80.6-1.00.9-1.0-1.4
Saline control response2.53.24.01.9-1.6-1.8-1.71.5-1.82.0-1.9-2.0
Bone: connectivity density1.32.114.23.80.10.80.8-1.20.7-0.20.70.7
Bone: cortical apparent density6.28.210.4-0.32.63.13.2-2.73.1-3.23.23.0
Bone: cortical area1.42.17.82.8-1.9-1.2-1.10.5-1.11.6-1.0-0.5
Bone: cortical porosity2.93.24.1-1.5-1.1-1.9-1.91.9-1.91.6-1.9-2.0
Bone: cortical porosity3.13.34.5-0.9-1.4-2.1-2.11.9-2.11.7-2.0-2.0
Bone: cortical thickness0.40.74.42.1-0.60.20.2-0.60.30.20.40.7
Bone: cortical thickness1.11.39.33.1-1.1-0.5-0.4-0.1-0.30.5-0.3-0.1
Bone: cortical tissue density6.38.310.6-0.32.63.23.2-2.73.1-3.23.23.1
Condit. Reinf. active minus inactive responses3.33.74.8-0.9-2.0-2.1-2.12.2-2.02.1-2.0-1.8
Condit. Reinf. active-inactive response ratio3.23.44.1-1.1-1.8-2.0-2.02.0-1.92.0-2.0-1.7
Condit. Reinf. active responses5.16.38.0-1.1-2.6-2.7-2.62.8-2.62.7-2.6-2.4
Condit. Reinf. inactive responses0.60.71.3-0.5-1.0-0.8-0.81.2-0.90.9-0.8-0.7
Incentive salience index mean2.12.53.3-1.4-1.3-1.6-1.61.8-1.71.7-1.7-1.6
Condit. Reinf. lever presses0.50.73.3-1.8-0.1-0.5-0.50.8-0.70.7-0.7-0.8
Condit. Reinf. active minus inactive responses0.91.11.50.9-1.0-1.0-0.91.0-1.01.2-1.1-1.1
Condit. Reinf. active-inactive response ratio0.10.10.40.6-0.10.10.20.20.00.2-0.0-0.1
Condit. Reinf. active responses1.21.72.80.7-0.9-1.4-1.31.1-1.31.4-1.5-1.7
Condit. Reinf. inactive responses0.81.01.50.2-0.8-1.2-1.20.7-1.11.1-1.1-1.1
Condit. Reinf. lever presses3.34.57.3-0.7-1.5-2.3-2.22.3-2.32.0-2.4-2.7
Condit. Reinf. lever reinforcers received1.01.32.20.7-0.9-1.2-1.20.9-1.11.3-1.4-1.5
Conditioned reinforcement - actives0.50.52.3-1.51.20.20.5-0.20.5-0.30.1-0.1
Conditioned reinforcement - inactives0.80.81.4-1.0-0.9-0.9-0.91.1-1.20.8-0.8-0.5
Conditioned locomotion0.40.41.8-0.9-0.0-0.2-0.0-0.50.8-0.00.41.3
Patch foraging indifference point 0 sec0.40.61.91.4-0.30.50.7-0.81.00.00.51.1
Patch foraging indifference point AUC0.40.40.8-0.9-0.4-0.6-0.40.6-0.90.6-0.7-0.6
Delay disc. indifference point, 0s delay0.30.41.11.01.00.1-0.1-0.50.40.0-0.2-0.9
Delay disc. indifference point, 16s delay0.40.51.6-0.1-0.70.50.8-0.10.4-0.50.81.3
Delay disc. indifference point, 2s delay0.60.61.01.0-0.8-0.9-1.00.4-0.21.0-0.8-0.7
Delay disc. indifference point, 24s delay0.40.41.5-0.3-1.10.20.20.10.6-0.30.61.2
Delay disc. indifference point, 4s delay0.40.51.81.4-0.5-0.5-0.50.4-0.20.7-0.6-0.8
Delay disc. indifference point, 8s delay0.30.31.2-0.1-1.1-0.1-0.30.10.80.20.20.9
Indifference point function ln k0.20.30.70.10.80.60.6-0.60.8-0.30.50.5
Indifference point function log k0.20.30.70.10.80.60.6-0.60.8-0.30.50.5
Patch foraging total patch changes 0 sec0.30.51.21.1-0.10.50.7-0.70.9-0.10.40.8
Patch foraging total patch changes 12 sec0.40.50.80.8-0.10.80.8-0.70.5-0.60.70.9
Patch foraging total patch changes 18 sec0.20.32.01.4-0.50.10.1-0.2-0.10.2-0.10.1
Patch foraging total patch changes 24 sec0.10.10.90.9-0.10.10.3-0.40.10.1-0.10.1
Patch foraging total patch changes 6 sec0.10.20.50.7-0.7-0.4-0.30.2-0.40.6-0.5-0.1
Patch foraging time to switch 0 sec0.50.81.41.10.11.00.7-0.60.6-1.11.21.2
Patch foraging water rate 0 sec0.61.01.8-0.8-0.3-1.1-0.91.0-0.81.2-1.3-1.3
Patch foraging water rate 12 sec0.20.31.41.20.70.30.4-0.60.3-0.30.2-0.2
Patch foraging water rate 18 sec0.40.61.3-0.90.5-0.8-0.60.5-0.20.8-0.9-1.2
Patch foraging water rate 24 sec0.30.52.50.61.60.50.6-0.60.3-0.30.2-0.5
Patch foraging water rate 6 sec0.40.62.01.40.1-0.5-0.40.2-0.80.6-0.7-1.1
Seeking ratio, delayed vs. immediate footshock1.61.93.20.90.61.41.1-1.51.6-1.31.61.8
Distance traveled before self-admin0.60.61.2-0.60.40.80.7-0.80.7-1.00.91.1
Distance traveled after self-admin1.51.73.1-0.81.51.21.2-1.40.9-1.81.31.2
Extensor digitorum longus weight3.714.618.3-1.7-3.7-4.2-4.04.1-4.04.3-4.1-3.6
Bone: elastic displacement0.20.20.70.8-0.0-0.3-0.3-0.1-0.30.6-0.4-0.5
Bone: elastic work1.01.34.02.0-0.8-1.0-1.00.2-0.91.5-1.1-1.1
Bone: endosteal estimation1.43.14.01.4-1.6-1.9-1.91.5-1.72.0-1.9-1.9
Bone: endosteal perimeter1.43.03.81.9-1.9-1.8-1.81.3-1.81.8-1.7-1.6
Epididymis fat weight0.81.92.61.30.61.61.3-1.21.4-1.51.61.6
Delta time in closed arm before/after self-admin0.20.20.90.90.2-0.0-0.20.1-0.70.1-0.1-0.5
Delta time in open arm before/after self-admin0.10.10.2-0.4-0.4-0.4-0.30.30.10.3-0.5-0.3
Diff in mean of infusions in LGA sessions1.51.62.5-0.0-1.6-1.5-1.51.2-0.81.6-1.4-0.9
Delay discount exponential model param0.30.31.8-0.41.30.40.4-0.4-0.4-0.50.2-0.4
Extinction: sum of active levers before priming1.51.53.0-1.7-1.4-1.4-1.31.3-0.51.3-1.1-0.3
Active lever presses in extinction session 60.30.30.80.2-0.5-0.5-0.60.5-0.90.4-0.6-0.6
Bone: final force1.52.38.42.9-1.8-1.3-1.30.5-1.01.7-1.1-0.7
Bone: final moment1.32.18.62.9-1.6-1.2-1.10.3-0.81.7-1.0-0.7
Food consumed during 24 hour testing period0.60.71.0-0.60.91.01.0-0.71.0-0.80.80.9
Glucose0.20.41.21.1-0.9-0.4-0.40.7-0.50.2-0.3-0.2
Heart weight0.00.10.20.5-0.3-0.1-0.10.4-0.00.2-0.10.0
Delay discount hyperbolic model param0.50.52.0-0.51.40.70.7-0.6-0.1-0.80.5-0.0
Intermittent access intake day 1-15 change0.20.20.7-0.80.1-0.3-0.10.5-0.10.4-0.3-0.3
Intermittent access intake escalation0.30.31.5-1.20.3-0.4-0.10.6-0.50.4-0.4-0.5
Intermittent access intake escalation 20.20.20.9-0.81.00.30.5-0.10.2-0.20.2-0.1
Intermitt. access day 1 inactive lever presses0.80.93.1-1.7-0.3-0.8-0.81.0-0.90.6-0.8-0.8
Intermitt. access day 15 inactive lever presses1.51.64.8-2.20.9-0.7-0.71.0-1.50.4-1.1-1.9
Intermitt. access escalation Index0.30.32.0-1.40.2-0.3-0.20.3-0.1-0.1-0.3-0.3
Intermittent access day 1 total infusions0.40.50.8-0.9-0.4-0.6-0.90.9-0.40.5-0.7-0.6
Intermittent access day 15 total infusions0.70.84.2-2.00.0-0.6-0.60.9-0.40.5-0.6-0.5
Intermittent access terminal intake (last 3 days)0.70.83.5-1.90.5-0.6-0.60.8-0.30.5-0.8-1.0
Intermittent access total infusions0.60.73.3-1.80.2-0.6-0.70.8-0.20.4-0.7-0.7
Intermittent access day 1 locomotion0.30.31.7-1.30.3-0.4-0.40.4-0.30.1-0.3-0.2
Intermittent access day 15 total locomotion0.10.10.7-0.9-0.2-0.3-0.30.30.20.2-0.10.3
Intermittent access total locomotion0.40.42.0-1.40.1-0.6-0.70.50.10.5-0.5-0.2
Intermittent access standard deviation2.52.64.6-0.32.01.71.9-1.52.2-1.61.61.1
Left kidney weight0.41.02.11.10.80.91.0-1.11.5-0.70.90.8
Right kidney weight0.20.61.50.20.90.80.9-0.91.2-0.60.60.5
Cocaine induced anxiety2.12.43.80.62.01.71.6-1.71.9-1.61.51.0
Post-drug Anxiety0.80.91.6-1.01.30.90.7-0.71.2-1.10.80.5
Baseline Anxiety4.64.96.2-1.8-2.1-2.4-2.32.5-2.32.3-2.3-1.9
Tail length0.20.72.50.9-0.50.60.6-0.80.8-0.50.91.6
Length with tail0.30.91.80.3-1.3-1.3-1.20.7-0.81.1-0.9-0.5
Length without tail1.22.75.0-0.4-0.7-1.9-1.91.4-1.81.6-1.9-2.2
Times rat made contact with spout2.02.33.11.11.71.81.7-1.61.6-1.51.51.1
Lifetime Intake0.40.42.1-1.50.5-0.3-0.40.5-0.30.2-0.5-0.6
Liver weight, left0.20.40.50.2-0.7-0.6-0.70.7-0.60.4-0.6-0.6
Liver weight, right1.01.73.10.4-1.0-1.3-1.41.3-1.61.3-1.4-1.8
Locomotor activity0.61.01.5-0.4-0.4-1.1-1.21.1-1.01.0-1.2-1.2
Locomotor testing distance1.42.43.6-0.4-1.3-1.7-1.91.7-1.51.5-1.7-1.6
Locomotor testing rearing0.40.71.41.1-0.4-0.8-0.90.5-0.70.7-0.9-1.2
Locomotion in novel chamber2.53.17.0-1.92.61.41.3-1.72.0-1.71.41.3
Locomotion in novel chamber post-restriction0.30.40.7-0.80.80.50.2-0.60.8-0.60.50.3
Fecal boli incidents, locomotor time 10.40.41.9-0.7-1.0-0.00.00.10.60.20.41.4
Change in fecal boli incidents, locomotor task1.81.72.41.50.31.31.1-1.31.5-1.41.41.4
Time >=10cm from walls, locomotor time 12.72.76.10.30.61.61.7-1.81.7-1.62.02.5
Bouts of movement, locomotor time 10.10.10.2-0.20.1-0.20.1-0.2-0.50.3-0.10.3
Total resting periods, locomotor time 10.30.30.60.30.70.40.8-0.8-0.0-0.20.40.6
Rest time, locomotor task time 10.40.41.40.81.20.50.6-0.8-0.4-0.30.3-0.1
Distance moved, locomotor task time 10.40.41.8-0.8-1.3-0.5-0.50.80.30.3-0.20.3
Vertical activity count, locomotor time 10.50.52.4-1.5-0.7-0.6-0.70.80.10.1-0.4-0.2
Time >=10cm from walls, locomotor time 20.30.30.9-0.21.00.60.5-0.70.5-0.70.50.2
Bouts of movement, locomotor time 20.40.52.6-1.61.0-0.0-0.10.0-0.4-0.4-0.2-0.7
Total resting periods, locomotor time 20.40.41.3-1.20.9-0.1-0.10.1-0.6-0.2-0.4-0.9
Rest time, locomotor task time 20.40.53.11.80.50.10.5-0.6-0.40.2-0.1-0.3
Distance moved, locomotor task time 20.20.30.8-0.9-0.8-0.3-0.50.60.3-0.0-0.10.2
Vertical activity count, locomotor time 20.20.20.8-0.9-0.40.1-0.50.20.2-0.40.20.3
Light reinforcement 10.61.14.80.1-2.2-1.1-0.91.1-0.01.3-0.80.2
Light reinforcement 20.60.83.9-2.0-1.2-0.5-0.50.80.30.3-0.20.6
Bone: marrow area1.43.03.81.4-1.5-1.8-1.81.5-1.72.0-1.9-1.9
Bone: maximum diameter0.51.07.42.7-1.0-0.3-0.3-0.2-0.30.3-0.10.1
Bone: maximum force1.72.95.22.3-1.9-1.7-1.71.0-1.42.1-1.6-1.2
Bone: maximum moment1.42.34.92.2-1.6-1.5-1.40.8-1.22.0-1.5-1.2
Mean time between licks in bursts4.56.48.8-2.1-2.1-2.7-2.83.0-2.42.4-2.7-2.6
Mean num. licks in bursts1.51.82.4-1.51.41.41.3-0.91.5-1.31.21.2
Cd content in liver0.60.61.2-0.90.50.70.7-0.70.7-0.80.81.1
Co content in liver0.50.61.4-1.2-0.4-0.7-0.70.9-0.70.5-0.7-0.8
Cu content in liver0.91.12.4-0.1-1.5-1.1-1.11.2-1.10.9-0.9-0.5
Fe content in liver0.91.12.31.50.41.11.1-0.91.1-1.11.11.0
K content in liver1.41.42.1-0.4-0.9-1.3-1.31.1-1.31.1-1.4-1.4
Mg content in liver2.12.12.7-0.8-1.2-1.6-1.61.6-1.61.3-1.6-1.6
Mn content in liver0.30.30.90.6-0.9-0.5-0.50.6-0.40.4-0.4-0.3
Na content in liver0.50.60.90.6-0.8-1.0-1.00.6-0.90.4-0.7-0.8
Rb content in liver0.10.10.5-0.3-0.7-0.2-0.20.6-0.20.4-0.10.2
Se content in liver1.01.32.20.30.51.21.2-0.91.3-1.51.31.3
Sr content in liver1.81.62.60.01.21.31.3-1.51.3-1.61.41.3
Zn content in liver0.40.40.9-0.70.10.60.6-0.30.6-0.70.70.9
Bone: minimum diameter3.56.58.32.1-2.8-2.7-2.72.2-2.52.9-2.6-2.3
Time in familiar zone, hab. session 11.71.62.10.91.11.31.3-1.41.3-1.41.41.2
Time in novel zone, hab. session 10.80.71.10.4-1.0-0.9-0.90.9-0.91.0-0.9-0.7
Total zone transitions, hab. session 11.82.53.4-0.8-1.8-1.8-1.81.7-1.51.6-1.6-1.3
Total locomotion distance, hab. session 10.81.22.8-1.7-0.9-1.2-1.11.2-0.90.8-0.9-0.7
Locomotion velocity, hab. session 11.11.65.4-2.3-0.8-1.3-1.21.3-1.00.9-1.1-0.9
Time in familiar zone, hab. session 26.97.110.21.83.02.92.9-3.22.8-2.52.62.1
Time in novel zone, hab. session 25.15.17.7-0.6-2.8-2.5-2.52.6-2.42.2-2.2-1.6
Total zone transitions, hab. session 21.01.31.7-1.1-0.8-1.3-1.21.1-1.01.1-1.2-1.2
Total locomotion distance, hab. session 20.91.22.6-1.6-0.7-1.1-1.11.2-0.90.9-1.1-1.0
Locomotion velocity, hab. session 21.01.43.9-2.0-0.8-1.2-1.11.3-0.91.0-1.1-0.9
Novel to familiar place preference ratio1.31.41.8-0.6-0.9-1.3-1.21.1-1.31.3-1.3-1.3
Novelty place preference1.01.11.5-0.5-0.7-1.1-1.10.9-1.11.1-1.2-1.2
Time in novel zone, NPP test1.01.01.5-0.3-0.7-1.1-1.10.9-1.11.1-1.2-1.2
Total zone transitions, NPP test1.11.63.7-1.9-0.7-1.4-1.31.2-1.11.1-1.2-1.2
Total locomotion distance, NPP test0.81.15.1-2.3-0.2-1.0-0.90.8-0.70.6-0.8-0.7
Locomotion velocity, NPP test0.91.26.8-2.6-0.1-0.9-0.90.8-0.70.6-0.8-0.7
Intraocular pressure0.40.51.4-0.70.20.60.8-0.50.8-0.60.81.2
Delta distance traveled before/after self-admin1.92.02.90.21.71.31.5-1.71.4-1.61.51.4
Delta ambulatory time before/after self-admin2.83.15.20.22.31.71.9-2.11.7-2.01.81.5
Parametrial fat weight0.10.30.70.9-0.30.40.4-0.40.4-0.50.60.7
Pavlov. Cond. lever latency0.30.40.80.60.00.30.4-0.50.8-0.70.70.9
Pavlov. Cond. magazine entry latency0.00.10.30.50.20.20.2-0.20.0-0.00.20.1
Pavlov. Cond. change in total contacts0.40.41.6-1.30.60.70.7-0.10.3-0.40.50.4
Pavlov. Cond. index score0.10.10.30.10.60.50.5-0.30.2-0.20.20.1
Pavlov. Cond. latency score0.10.10.4-0.00.60.50.5-0.30.2-0.30.30.1
Pavlov. Cond. lever contacts0.30.40.8-0.80.2-0.3-0.30.5-0.70.6-0.7-0.9
Pavlov. Cond. magazine entry number0.10.10.8-0.9-0.0-0.2-0.20.30.0-0.2-0.1-0.2
Pavlov. Cond. intertrial magazine entries1.31.57.1-2.7-0.1-0.9-0.91.3-1.00.5-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.10.60.50.5-0.30.2-0.30.30.1
Pavlov. Cond. response bias0.10.20.3-0.0-0.1-0.3-0.30.2-0.60.6-0.5-0.6
Pavlov. Cond. lever latency1.92.63.10.61.61.81.7-1.81.7-1.61.71.7
Pavlov. Cond. magazine entry latency0.40.42.11.5-0.4-0.5-0.5-0.0-0.50.5-0.5-0.6
Pavlov. Cond. change in total contacts1.62.12.7-0.1-1.6-1.6-1.61.6-1.51.3-1.6-1.6
Pavlov. Cond. index score1.62.02.60.2-1.4-1.6-1.51.3-1.61.4-1.6-1.6
Pavlov. Cond. latency score1.51.92.40.4-1.4-1.5-1.51.3-1.51.4-1.5-1.5
Pavlov. Cond. lever contacts1.01.41.8-0.8-1.0-1.3-1.21.3-1.21.0-1.3-1.3
Pavlov. Cond. magazine entry number0.20.21.1-1.00.50.40.3-0.10.4-0.30.30.4
Pavlov. Cond. intertrial magazine entries0.10.20.9-1.00.40.20.2-0.00.2-0.50.30.4
Pavlov. Cond. lever-magazine prob. diff.1.21.51.80.2-1.3-1.4-1.31.2-1.31.2-1.3-1.3
Pavlov. Cond. response bias1.01.41.8-0.2-1.2-1.4-1.31.2-1.21.2-1.3-1.3
Time in closed arm before self-admin0.50.52.3-0.21.50.50.6-0.80.7-0.60.4-0.1
Time in closed arm after self-admin0.70.73.4-0.51.80.80.6-0.70.6-0.80.6-0.1
Time in open arm before self-admin1.01.12.90.7-1.7-0.9-1.11.1-1.30.8-0.7-0.5
Time in open arm after self-admin0.80.92.11.2-1.4-0.8-0.70.8-0.90.8-0.8-0.6
Bone: periosteal estimation1.93.85.52.4-2.2-2.0-1.91.4-1.82.3-1.9-1.6
Bone: periosteal perimeter1.22.06.82.6-1.5-1.2-1.20.5-1.21.5-1.1-0.8
Bone: post-yield work2.43.34.2-0.6-1.7-2.0-1.92.0-1.92.1-2.0-1.8
Progressive ratio test 1 active lever presses0.20.31.0-1.0-0.3-0.5-0.70.4-0.30.4-0.30.1
Progressive ratio test 1 breakpoint0.30.30.9-0.9-0.2-0.5-0.70.5-0.40.4-0.4-0.2
Progressive ratio test 1 inactive lever presses0.91.03.2-1.8-1.1-0.9-1.11.0-0.90.6-0.60.1
Progressive ratio test 2 active lever presses1.11.24.0-0.6-2.0-1.2-1.21.3-0.31.1-0.70.2
Progressive ratio test 2 breakpoint1.01.13.3-0.4-1.8-1.2-1.11.4-0.31.1-0.8-0.1
Progressive ratio test 2 inactive lever presses0.20.31.7-1.3-0.2-0.2-0.20.20.60.3-0.00.6
Incentive Sensitization - Responses2.12.17.3-0.2-2.7-1.6-1.41.7-0.61.6-1.0-0.0
Incentive Sensitization - Breakpoint1.81.86.1-0.4-2.5-1.5-1.31.7-0.61.5-1.0-0.0
Sum of active levers in priming session hrs 5-60.70.62.6-1.6-0.9-0.7-0.60.9-0.00.6-0.5-0.0
Progressive ratio0.20.20.50.7-0.7-0.2-0.40.5-0.30.4-0.3-0.3
Food seeking constrained by brief footshock0.10.10.5-0.10.10.00.1-0.30.7-0.10.10.3
Seeking ratio, punishment vs. effort0.10.10.8-0.90.1-0.30.0-0.10.2-0.0-0.10.1
Retroperitoneal fat weight0.10.41.50.7-1.2-0.5-0.60.7-0.10.6-0.3-0.2
Reaction time number correct2.53.64.72.21.52.02.1-2.12.1-1.71.81.6
Reaction time mean minus median2.73.56.2-0.5-2.5-2.0-2.12.2-2.31.7-1.7-1.3
Reaction time mean minus median AUC5.16.610.2-1.0-3.1-2.7-2.63.1-3.22.4-2.4-2.0
Reaction time num false alarms0.91.26.82.6-1.5-0.7-0.40.20.10.9-0.40.1
Reaction time num false alarms AUC0.81.27.32.7-1.4-0.5-0.40.10.10.7-0.30.1
Reaction time trials correct on left2.53.64.72.21.52.02.1-2.12.1-1.71.81.6
Reaction time trials on left2.33.34.52.11.41.92.0-2.01.9-1.61.81.5
Reaction time mean1.82.65.0-0.8-1.5-1.7-1.81.8-2.21.4-1.5-1.4
Reaction time mean AUC3.14.27.5-1.0-2.0-2.2-2.32.3-2.71.9-1.9-1.7
Median of all reaction times1.11.53.3-0.7-1.0-1.2-1.31.4-1.81.0-1.1-1.2
Reaction time omissions3.65.07.7-1.0-2.7-2.3-2.42.8-2.52.1-2.0-1.7
Reaction time false alarm rate1.31.94.91.4-2.2-1.4-1.41.1-0.81.5-1.1-0.5
Reaction time premature initiation rate0.50.72.11.01.40.80.9-0.90.2-0.50.4-0.4
Reaction time premature initiations1.72.44.02.02.01.61.8-1.81.1-1.31.20.4
Std. dev. reaction times3.65.19.8-0.5-2.0-2.3-2.42.4-3.12.1-2.2-2.2
Reaction time trials completed2.33.34.52.11.41.92.0-2.01.9-1.61.81.5
Reaction time trials AUC2.23.24.12.01.31.81.9-2.01.9-1.61.81.5
Run reversals in cocaine runway, females0.30.32.1-1.5-0.3-0.4-0.30.40.00.2-0.30.0
Run reversals in cocaine runway, males0.10.10.5-0.70.50.10.2-0.30.6-0.10.10.2
Latency to leave start box in cocaine runway0.20.20.40.10.10.60.4-0.2-0.1-0.50.60.6
Latency to leave start box in cocaine runway, F0.50.61.90.6-0.10.70.8-0.60.3-0.61.01.4
Latency to leave start box in cocaine runway, M0.20.20.8-0.90.80.2-0.20.2-0.2-0.3-0.1-0.7
Std. dev. time between licks in bursts6.78.010.6-0.4-3.1-3.2-3.13.3-2.73.0-3.0-2.7
Total sessions with >9 infusions0.50.62.0-1.4-0.1-0.6-0.90.6-1.10.3-0.5-0.2
Short access day 1 total inactive lever presses0.60.72.6-1.6-0.1-0.8-0.90.6-0.70.7-0.8-0.4
Short access day 10 total inactive lever presses0.20.30.90.4-0.9-0.3-0.30.5-0.70.5-0.3-0.1
Short access day 1 total infusions0.70.73.6-1.91.50.40.2-0.3-0.2-0.60.2-0.2
Short access day 10 total infusions0.40.51.7-1.30.8-0.3-0.50.4-0.50.1-0.5-0.9
Short access total infusions0.40.40.9-0.90.2-0.4-0.60.6-0.80.3-0.7-1.0
Short access day 1 locomotion0.20.21.0-0.31.00.0-0.1-0.1-0.5-0.2-0.2-0.6
Short access day 10 total locomotion1.82.05.0-0.52.21.41.5-1.51.2-1.61.30.8
Short access total locomotion0.20.20.9-0.80.90.2-0.1-0.2-0.2-0.40.1-0.1
One hour access (0.3 mA shock)0.30.31.1-0.4-1.1-0.3-0.20.40.70.5-0.00.7
Compulsive drug intake1.91.99.23.0-2.5-0.6-0.40.30.40.9-0.30.2
One hour access (shock baseline)0.70.95.7-2.41.20.30.3-0.10.1-0.40.30.3
Social response proportion0.10.10.3-0.3-0.2-0.5-0.40.2-0.20.6-0.4-0.3
Social responses0.20.32.21.5-0.2-0.1-0.1-0.2-0.20.5-0.2-0.3
Social time0.10.10.40.3-0.60.10.0-0.10.40.40.10.7
Soleus weight0.20.61.20.90.80.80.7-1.10.7-0.70.70.6
Bone: stiffness0.20.30.60.6-0.8-0.8-0.70.4-0.50.6-0.5-0.3
Tibialis anterior weight0.20.91.30.50.71.01.1-1.01.1-0.71.01.1
Time to tail flick, vehicle, before self-admin0.20.22.01.4-0.10.20.0-0.10.20.1-0.0-0.3
Time to tail flick, vehicle, after self-admin3.43.66.3-1.4-2.5-2.1-1.92.2-1.62.2-1.8-0.9
Time to tail flick, test, before self-admin1.21.22.0-1.4-1.3-1.4-1.21.0-0.61.0-0.9-0.2
Time to tail flick, test, after self-admin0.80.82.2-1.51.50.40.7-0.61.2-0.40.30.2
Delta time to tail flick, vehicle, before/after SA1.41.44.6-2.2-1.2-1.2-1.01.2-0.91.1-0.8-0.0
Delta time to tail flick, test, before/after SA1.31.22.40.11.31.21.2-1.01.5-1.01.00.8
Tibia length0.10.21.0-1.00.1-0.4-0.30.2-0.40.4-0.4-0.2
Ambulatory time before self-admin0.10.10.2-0.3-0.50.1-0.10.0-0.0-0.30.10.3
Ambulatory time after self-admin3.03.35.4-0.32.31.81.8-2.01.7-2.31.81.3
Bone: tissue strength0.10.10.8-0.90.3-0.10.00.00.10.0-0.1-0.1
Total heroin consumption0.10.10.60.00.1-0.0-0.0-0.20.80.1-0.1-0.0
Bone: trabecular number3.14.927.35.20.81.51.5-2.21.5-0.91.51.2
Bone: trabecular spacing2.02.615.6-3.90.0-1.0-1.11.3-1.10.3-1.0-1.2
Bone: trabecular thickness6.47.615.03.91.72.72.7-3.12.9-2.22.72.6
Bone: trabecular tissue density0.71.03.3-1.80.90.70.9-0.30.9-1.00.80.9
Water consumed over 24 hours0.50.63.81.90.30.60.6-0.80.5-0.30.50.4
Number of responses in last shaping day0.70.71.2-0.90.90.90.6-0.51.1-1.00.80.7