Hub : Genes

Lsm2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr20_3848861_3851065 0.04 0.02 8.6e-03 0.02 0.02 0.02 0.02 9.9e-03 6.0e-03 1.3e-02 1.2e-02
2 OFC gene expression Lsm2 0.18 0.14 9.1e-03 0.04 0.05 0 0.04 4.7e-02 2.1e-02 2.5e-01 3.3e-02
3 Liver intron excision ratio chr20_3848861_3851065 0.28 0.1 0.0e+00 0.08 0.12 0.1 0.11 1.7e-09 4.9e-13 1.0e-10 2.7e-12
4 Liver intron excision ratio chr20_3851132_3851663 0.27 0.1 2.2e-16 0.08 0.11 0.09 0.1 1.4e-09 2.8e-12 1.5e-10 3.6e-11
5 NAcc intron excision ratio chr20_3848861_3851065 0.06 0.04 3.6e-07 0.03 0.04 0.03 0.03 3.0e-05 1.2e-06 7.6e-05 1.5e-05
6 BLA gene expression Lsm2 0.17 0.12 6.7e-04 0.07 0.04 0.07 0.07 1.1e-04 3.4e-03 1.3e-04 1.8e-04
7 NAcc intron excision ratio chr20_3851132_3851663 0.05 0.03 5.2e-06 0.03 0.03 0.02 0.02 3.5e-05 1.4e-05 2.3e-04 2.2e-04
8 PL gene expression Lsm2 0.13 0.07 1.3e-08 0.09 0.08 0.08 0.09 3.4e-10 2.8e-09 9.3e-09 4.9e-10
9 Adipose gene expression Lsm2 0.05 0.03 5.2e-05 0.05 0.04 0.04 0.04 4.7e-06 3.7e-05 5.7e-05 1.3e-05
10 IC gene expression Lsm2 0.11 0.07 2.0e-03 0.02 0.03 0.01 0.02 4.0e-02 2.6e-02 1.1e-01 6.8e-02
11 NAcc gene expression Lsm2 0.09 0.04 2.1e-12 0.09 0.08 0.08 0.08 1.9e-13 8.5e-12 7.0e-12 2.5e-12
12 Liver gene expression Lsm2 0.05 0.03 4.5e-04 0.01 0.02 0 0.01 2.4e-02 1.8e-03 1.4e-01 8.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.50.83.7-0.70.1-1.91.9-0.70.30.70.30.20.80.2-0.6
Area under the delay curve0.30.51.50.40.21.0-0.90.6-1.2-0.6-0.6-0.60.1-0.60.8
BMI with tail2.27.710.6-2.6-2.6-2.32.4-2.93.22.93.03.0-2.73.3-2.1
BMI without tail1.05.510.1-2.5-3.0-0.70.8-2.42.62.42.62.6-3.22.80.1
Body weight1.77.316.2-2.0-2.9-0.30.4-2.33.32.43.33.3-4.03.5-1.9
Weight adjusted by age0.41.34.0-0.6-1.30.3-0.4-0.90.70.91.41.4-2.01.4-0.8
Bone surface0.00.10.20.30.20.2-0.20.20.2-0.20.0-0.0-0.0-0.0-0.5
Bone volume0.20.30.6-0.5-0.3-0.80.8-0.60.70.60.50.5-0.20.5-0.5
Breakpoint value in progressive ratio session0.30.50.90.70.60.6-0.60.7-0.8-0.7-0.9-0.90.7-0.80.4
Number of licking bursts0.92.63.71.91.71.8-1.81.9-1.3-1.9-1.7-1.71.2-1.60.1
Context. condit. distance diff. score3.54.38.62.72.90.8-0.82.2-2.0-2.2-2.2-2.12.6-2.0-1.2
Locomotion velocity, session 11.41.62.81.21.21.0-1.11.3-1.7-1.3-1.4-1.41.2-1.21.0
Locomotion distance, session 10.20.31.00.00.5-1.00.9-0.0-0.4-0.0-0.4-0.41.0-0.3-0.2
Locomotion velocity, session 21.01.21.61.11.20.8-0.81.2-1.2-1.2-1.3-1.21.1-1.20.4
Locomotion distance, session 20.50.61.60.71.1-0.70.70.5-0.8-0.5-0.7-0.71.3-0.5-1.0
Locomotion velocity, session 30.20.21.1-0.7-0.6-0.20.1-0.40.10.40.0-0.0-0.20.41.0
Locomotion distance, session 30.60.72.30.51.0-0.50.40.5-1.0-0.6-1.0-1.11.5-0.90.4
Stereotopy head waving bouts, day 30.60.72.90.80.31.7-1.70.9-0.3-0.8-0.4-0.4-0.4-0.30.1
Stereotopy head waving duration, day 30.40.52.20.3-0.31.5-1.50.4-0.2-0.3-0.0-0.0-0.8-0.10.8
Locomotion velocity, session 71.51.64.70.81.7-1.41.40.5-1.4-0.6-1.0-1.02.2-0.9-1.2
Locomotion distance, session 71.82.37.31.01.9-1.00.91.0-1.9-1.1-1.6-1.72.7-1.6-0.1
Stereotopy head waving bouts, day 71.21.45.00.40.11.7-1.70.9-1.0-0.9-1.0-1.10.2-1.02.2
Stereotopy head waving duration, day 70.50.62.50.0-0.31.2-1.20.4-0.4-0.4-0.5-0.5-0.3-0.41.6
Locomotion velocity, session 84.95.99.03.02.72.6-2.62.8-2.3-2.8-2.4-2.51.8-2.2-0.0
Locomotion distance, session 82.84.09.42.53.10.0-0.01.9-1.8-2.0-1.9-1.92.8-1.6-2.1
Degree of sensitization distance0.60.71.31.11.00.9-0.81.0-0.7-1.0-0.7-0.60.6-0.7-0.5
Degree of sensitization stereotypy1.11.24.20.40.31.1-1.10.9-1.1-0.9-1.2-1.20.7-1.12.1
Conditioned locomotion0.30.41.70.0-0.20.1-0.1-0.20.80.30.70.7-0.80.6-1.3
Cocaine response after cond. corrected0.40.64.40.40.7-0.70.80.00.5-0.00.20.20.40.1-2.1
Cocaine response after cond. not corrected0.30.41.20.90.70.8-0.80.70.1-0.6-0.2-0.2-0.0-0.2-1.1
Cocaine response before conditioning1.41.66.30.3-0.72.5-2.50.7-0.2-0.6-0.3-0.3-1.3-0.11.9
Saline control response3.24.58.8-2.7-3.0-0.80.8-2.22.12.32.32.3-2.51.91.3
Bone: connectivity density0.50.83.0-0.30.2-1.71.7-0.60.60.60.60.50.60.3-1.4
Bone: cortical apparent density1.82.83.7-1.9-1.8-1.51.6-1.81.91.81.81.7-1.51.7-0.5
Bone: cortical area0.10.10.50.30.10.7-0.70.4-0.0-0.3-0.2-0.3-0.3-0.00.0
Bone: cortical porosity2.52.710.00.60.21.9-2.01.2-2.0-1.2-1.5-1.60.5-1.53.2
Bone: cortical porosity2.83.18.01.00.62.2-2.31.5-2.2-1.5-1.6-1.60.7-1.72.8
Bone: cortical thickness0.71.12.3-1.5-1.3-1.01.1-1.21.11.20.90.8-0.91.00.3
Bone: cortical thickness2.02.43.9-2.0-1.7-1.51.5-1.71.71.71.51.5-1.31.60.1
Bone: cortical tissue density1.62.53.3-1.8-1.7-1.41.4-1.71.81.81.71.7-1.51.7-0.5
Condit. Reinf. active minus inactive responses1.11.23.30.60.70.5-0.60.9-1.8-0.9-1.3-1.31.1-1.11.5
Condit. Reinf. active-inactive response ratio0.20.21.5-0.5-0.50.1-0.1-0.2-0.40.2-0.1-0.1-0.20.01.2
Condit. Reinf. active responses0.40.51.80.20.5-0.40.30.4-1.4-0.4-0.8-0.81.1-0.60.7
Condit. Reinf. inactive responses0.50.62.6-0.30.4-1.61.6-0.3-0.40.3-0.2-0.21.1-0.1-0.3
Incentive salience index mean2.22.85.41.72.00.8-0.81.7-2.3-1.8-1.9-1.92.0-1.70.2
Condit. Reinf. lever presses2.33.57.72.42.80.5-0.51.9-1.9-2.0-1.7-1.72.4-1.7-1.6
Condit. Reinf. active minus inactive responses0.20.30.9-0.1-0.50.9-1.00.0-0.1-0.00.10.1-0.70.20.9
Condit. Reinf. active-inactive response ratio0.30.52.10.4-0.21.4-1.40.4-0.2-0.4-0.0-0.1-0.6-0.10.7
Condit. Reinf. active responses0.10.10.6-0.2-0.50.3-0.4-0.20.10.20.10.0-0.40.20.8
Condit. Reinf. inactive responses0.20.30.6-0.8-0.6-0.70.7-0.70.60.70.30.3-0.30.50.2
Condit. Reinf. lever presses0.20.31.50.10.10.2-0.30.2-0.7-0.3-0.5-0.50.5-0.51.2
Condit. Reinf. lever reinforcers received0.10.21.10.0-0.20.6-0.70.2-0.3-0.2-0.3-0.3-0.1-0.21.1
Conditioned reinforcement - actives0.10.40.8-0.7-0.6-0.90.8-0.80.30.70.60.6-0.30.6-0.0
Conditioned reinforcement - inactives0.10.30.6-0.7-0.7-0.80.7-0.8-0.20.70.50.5-0.40.50.3
Conditioned locomotion0.00.10.2-0.1-0.1-0.30.3-0.2-0.20.20.40.4-0.10.4-0.1
Patch foraging indifference point 0 sec1.13.05.5-2.1-2.3-0.90.9-1.91.61.92.02.0-2.01.70.7
Patch foraging indifference point AUC0.40.82.10.40.21.4-1.30.8-0.8-0.8-0.7-0.70.2-1.01.4
Delay disc. indifference point, 0s delay0.50.50.91.00.80.6-0.60.8-0.9-0.8-0.7-0.70.5-0.7-0.5
Delay disc. indifference point, 16s delay0.10.20.7-0.6-0.6-0.10.2-0.3-0.40.30.20.2-0.20.20.8
Delay disc. indifference point, 2s delay1.11.33.11.00.41.7-1.81.1-1.5-1.1-1.0-1.00.1-1.00.8
Delay disc. indifference point, 24s delay0.30.42.1-0.2-0.40.8-0.80.2-1.1-0.2-0.1-0.1-0.4-0.11.4
Delay disc. indifference point, 4s delay0.40.41.50.2-0.31.2-1.20.4-0.5-0.3-0.3-0.3-0.6-0.30.8
Delay disc. indifference point, 8s delay0.30.41.60.40.40.6-0.60.6-1.2-0.6-0.6-0.60.4-0.60.6
Indifference point function ln k0.51.52.11.31.21.2-1.21.3-1.5-1.3-1.4-1.51.0-1.10.4
Indifference point function log k0.51.52.11.31.21.2-1.21.3-1.5-1.3-1.4-1.51.0-1.10.4
Patch foraging total patch changes 0 sec1.13.25.9-2.2-2.4-1.01.0-1.91.61.92.02.0-2.11.70.8
Patch foraging total patch changes 12 sec1.11.53.0-1.6-1.7-0.40.4-1.21.21.31.31.3-1.50.91.0
Patch foraging total patch changes 18 sec2.04.66.7-2.6-2.3-2.12.2-2.32.32.32.42.4-1.71.9-0.1
Patch foraging total patch changes 24 sec0.62.03.8-1.9-1.4-2.02.0-1.61.01.61.31.3-0.50.90.3
Patch foraging total patch changes 6 sec1.62.84.6-2.1-2.1-1.01.1-1.81.51.81.91.9-1.71.50.7
Patch foraging time to switch 0 sec1.14.36.2-1.6-1.3-2.52.5-2.12.42.02.12.1-1.22.2-2.5
Patch foraging water rate 0 sec0.00.10.2-0.1-0.30.4-0.3-0.0-0.20.00.20.3-0.50.20.2
Patch foraging water rate 12 sec0.00.20.5-0.6-0.4-0.70.7-0.50.20.40.10.10.00.20.3
Patch foraging water rate 18 sec0.10.20.5-0.6-0.7-0.30.3-0.50.30.60.40.4-0.60.60.1
Patch foraging water rate 24 sec0.20.20.5-0.6-0.6-0.40.4-0.60.70.60.40.3-0.50.50.1
Patch foraging water rate 6 sec0.10.10.2-0.5-0.4-0.30.4-0.30.30.30.10.1-0.20.20.1
Seeking ratio, delayed vs. immediate footshock0.50.62.6-0.3-0.61.3-1.30.30.6-0.2-0.3-0.3-0.7-0.41.6
Distance traveled before self-admin0.20.52.50.10.1-0.30.3-0.31.20.30.60.6-0.50.6-1.6
Distance traveled after self-admin0.20.41.5-0.2-0.70.8-0.7-0.21.10.30.50.5-1.20.4-0.0
Extensor digitorum longus weight0.00.20.70.70.50.5-0.50.40.1-0.40.0-0.0-0.10.1-0.9
Bone: elastic displacement0.20.21.5-0.7-0.6-0.40.4-0.4-0.30.40.10.10.0-0.01.2
Bone: elastic work0.10.10.3-0.4-0.5-0.00.0-0.3-0.10.30.30.3-0.40.30.4
Bone: endosteal estimation0.81.98.11.50.32.8-2.81.1-0.0-1.0-0.1-0.2-1.20.0-0.5
Bone: endosteal perimeter1.12.76.42.31.62.5-2.51.9-0.9-1.8-1.1-1.10.2-0.9-0.8
Epididymis fat weight6.130.739.0-6.1-5.5-6.26.2-6.25.56.25.55.5-4.25.8-2.0
Delta time in closed arm before/after self-admin0.50.51.2-0.3-0.5-0.40.4-0.60.80.60.80.8-0.80.7-1.1
Delta time in open arm before/after self-admin0.20.30.5-0.7-0.7-0.60.5-0.70.30.60.40.4-0.30.50.5
Diff in mean of infusions in LGA sessions0.61.02.91.11.6-0.30.41.0-0.6-1.0-1.0-1.01.7-0.7-0.9
Delay discount exponential model param0.40.61.7-0.4-0.1-1.11.1-0.61.30.60.70.7-0.00.7-1.0
Extinction: sum of active levers before priming0.60.91.41.21.10.9-0.81.1-1.0-1.1-1.0-1.00.8-1.0-0.3
Active lever presses in extinction session 60.40.41.1-0.6-0.5-1.11.0-0.7-0.40.70.40.4-0.10.40.1
Bone: final force1.72.74.5-1.5-1.7-0.91.0-1.62.11.71.91.9-2.02.0-1.1
Bone: final moment1.52.43.5-1.5-1.6-0.90.9-1.51.91.61.81.8-1.91.8-0.9
Food consumed during 24 hour testing period0.20.43.10.30.10.1-0.0-0.10.70.10.50.5-0.60.6-1.8
Glucose4.36.811.43.42.82.9-3.03.0-2.6-3.0-2.4-2.51.8-2.3-0.3
Heart weight0.40.72.1-0.2-0.91.4-1.4-0.0-0.10.10.40.4-1.40.41.0
Delay discount hyperbolic model param0.60.82.0-0.5-0.1-1.21.3-0.71.40.70.80.8-0.00.8-1.2
Intermittent access intake day 1-15 change0.00.10.60.00.00.4-0.40.30.2-0.2-0.2-0.20.1-0.20.8
Intermittent access intake escalation0.00.32.0-0.7-0.60.10.0-0.20.40.20.10.1-0.20.11.4
Intermittent access intake escalation 20.30.51.00.40.40.8-0.70.7-0.4-0.7-0.8-0.80.4-0.81.0
Intermitt. access day 1 inactive lever presses0.10.92.21.51.11.0-1.01.0-0.4-0.9-0.8-0.80.3-0.8-1.3
Intermitt. access day 15 inactive lever presses0.00.20.5-0.2-0.40.1-0.1-0.30.30.30.50.5-0.70.5-0.3
Intermitt. access escalation Index0.51.52.91.41.70.3-0.21.3-0.8-1.3-1.4-1.41.7-1.4-0.8
Intermittent access day 1 total infusions0.10.41.30.00.4-1.00.9-0.1-1.20.0-0.3-0.31.0-0.30.4
Intermittent access day 15 total infusions0.10.31.4-0.6-0.4-0.70.7-0.4-0.30.30.00.00.30.01.2
Intermittent access terminal intake (last 3 days)0.10.31.7-0.6-0.5-0.40.3-0.4-0.40.40.10.1-0.00.01.3
Intermittent access total infusions0.20.30.8-0.6-0.4-0.80.7-0.5-0.60.40.20.20.20.20.9
Intermittent access day 1 locomotion0.30.61.5-0.7-0.4-1.21.2-0.80.40.80.80.8-0.10.8-0.4
Intermittent access day 15 total locomotion0.20.61.1-0.8-0.8-0.20.3-0.60.90.71.01.0-0.91.0-0.1
Intermittent access total locomotion0.60.71.0-1.0-0.9-0.80.8-0.90.50.91.01.0-0.61.00.2
Intermittent access standard deviation0.52.64.1-1.8-2.0-0.90.9-1.71.71.71.81.8-2.01.80.1
Left kidney weight1.08.016.2-2.6-3.4-0.70.7-2.73.22.83.33.3-4.03.5-0.9
Right kidney weight1.28.415.8-2.5-3.2-0.91.0-2.83.42.83.53.4-4.03.5-1.7
Cocaine induced anxiety0.10.30.70.70.70.4-0.40.6-0.1-0.5-0.4-0.40.3-0.4-0.9
Post-drug Anxiety0.10.10.30.2-0.00.3-0.30.00.4-0.00.00.0-0.30.0-0.5
Baseline Anxiety0.10.10.2-0.3-0.40.1-0.1-0.20.40.30.30.3-0.50.30.2
Tail length0.52.611.50.8-0.53.4-3.41.0-0.2-0.9-0.1-0.1-1.80.01.4
Length with tail0.52.07.10.5-0.92.7-2.60.30.6-0.20.80.8-2.51.0-0.3
Length without tail0.73.89.9-0.4-1.30.1-0.1-1.22.21.32.42.2-2.92.5-3.2
Times rat made contact with spout0.50.63.6-0.8-0.4-0.60.6-0.2-0.60.2-0.5-0.50.6-0.31.9
Lifetime Intake0.20.30.6-0.6-0.5-0.80.6-0.5-0.60.50.20.20.10.20.8
Liver weight, left0.50.82.61.20.51.6-1.60.80.5-0.7-0.0-0.1-0.60.1-1.2
Liver weight, right0.81.54.01.71.02.0-2.01.3-0.7-1.3-0.6-0.7-0.2-0.6-0.7
Locomotor activity0.50.83.20.5-0.11.8-1.80.7-0.2-0.6-0.5-0.5-0.6-0.51.1
Locomotor testing distance0.10.21.00.4-0.01.0-1.00.30.1-0.3-0.1-0.1-0.5-0.10.1
Locomotor testing rearing0.10.41.0-0.1-0.50.2-0.2-0.40.90.40.80.7-1.00.8-0.8
Locomotion in novel chamber0.00.00.3-0.2-0.3-0.10.1-0.20.50.2-0.0-0.1-0.2-0.10.0
Locomotion in novel chamber post-restriction0.51.62.5-1.2-1.4-0.70.7-1.31.41.31.51.5-1.61.5-0.6
Fecal boli incidents, locomotor time 10.40.92.4-0.6-0.6-1.61.4-1.10.31.00.90.9-0.30.8-1.0
Change in fecal boli incidents, locomotor task1.11.23.61.30.91.9-1.81.3-0.2-1.2-0.7-0.6-0.0-0.8-0.3
Time >=10cm from walls, locomotor time 10.81.04.50.1-0.40.4-0.3-0.41.40.40.90.9-1.41.0-2.1
Bouts of movement, locomotor time 10.50.61.10.70.90.4-0.40.9-0.7-0.8-0.9-1.11.0-0.90.3
Total resting periods, locomotor time 10.50.50.90.70.90.5-0.40.8-0.6-0.8-0.8-0.90.9-0.80.2
Rest time, locomotor task time 10.10.10.30.50.20.4-0.40.2-0.6-0.3-0.4-0.30.1-0.40.2
Distance moved, locomotor task time 10.00.10.3-0.4-0.40.2-0.1-0.20.40.30.50.5-0.60.5-0.0
Vertical activity count, locomotor time 10.10.81.3-1.0-1.0-0.40.5-0.81.10.81.01.0-1.00.9-0.4
Time >=10cm from walls, locomotor time 20.20.51.30.3-0.30.9-0.90.10.4-0.00.70.7-1.10.6-1.1
Bouts of movement, locomotor time 20.20.81.70.50.21.2-1.20.8-0.6-0.8-1.0-1.00.3-1.01.3
Total resting periods, locomotor time 20.41.83.11.00.61.7-1.81.3-1.2-1.3-1.5-1.50.6-1.51.6
Rest time, locomotor task time 20.61.02.31.51.30.8-0.71.1-0.4-1.1-0.9-0.90.7-0.9-1.3
Distance moved, locomotor task time 21.31.83.0-1.5-1.3-1.11.1-1.40.91.41.71.7-1.31.7-0.3
Vertical activity count, locomotor time 20.51.11.9-1.1-1.1-0.70.7-1.10.81.11.41.3-1.21.3-0.5
Light reinforcement 10.31.22.9-0.6-0.5-0.70.8-0.71.70.81.31.3-0.91.2-1.6
Light reinforcement 20.30.63.0-0.1-0.1-0.40.5-0.41.00.40.70.7-0.61.1-1.7
Bone: marrow area0.71.87.61.30.12.8-2.81.00.2-0.90.00.0-1.40.2-0.5
Bone: maximum diameter1.53.14.92.21.82.2-2.22.1-1.5-2.0-1.7-1.70.9-1.4-0.2
Bone: maximum force0.81.62.6-1.1-1.3-0.60.6-1.21.51.21.41.4-1.61.6-1.0
Bone: maximum moment0.61.22.2-0.9-1.2-0.50.5-1.11.21.11.31.3-1.51.4-0.8
Mean time between licks in bursts0.63.45.32.32.01.9-1.92.1-1.7-2.1-1.8-1.81.5-1.90.1
Mean num. licks in bursts1.02.65.0-2.2-1.9-1.91.9-1.91.01.81.31.3-0.91.41.0
Cd content in liver2.12.34.6-1.2-0.8-2.22.1-1.51.11.51.51.6-0.61.5-1.7
Co content in liver2.42.84.0-1.6-1.7-1.41.4-1.72.01.81.91.9-1.72.0-0.9
Cu content in liver0.40.51.6-0.8-0.2-0.90.9-0.3-0.70.3-0.7-0.70.7-0.31.3
Fe content in liver1.72.12.7-1.6-1.5-1.41.4-1.61.41.61.61.6-1.31.3-0.5
K content in liver0.30.30.90.50.8-0.20.20.5-0.4-0.5-0.7-0.70.9-0.6-0.3
Mg content in liver2.72.94.92.22.21.3-1.31.9-1.3-1.9-1.8-1.81.7-1.6-0.5
Mn content in liver2.52.85.72.42.21.6-1.62.0-1.6-1.9-1.4-1.41.3-1.1-1.3
Na content in liver0.30.41.30.00.20.4-0.40.4-0.6-0.4-0.7-0.80.5-0.91.2
Rb content in liver0.30.41.80.10.3-0.80.8-0.30.70.20.50.50.20.2-1.3
Se content in liver6.47.610.52.92.62.9-2.93.0-2.6-3.0-3.2-3.22.1-2.61.3
Sr content in liver0.30.30.9-0.1-0.3-0.00.0-0.30.00.30.81.0-0.60.7-0.5
Zn content in liver0.10.10.30.50.40.1-0.10.2-0.1-0.2-0.1-0.10.2-0.0-0.6
Bone: minimum diameter0.81.53.71.71.11.9-1.91.4-0.5-1.3-0.7-0.7-0.0-0.5-0.9
Time in familiar zone, hab. session 10.80.82.5-1.2-0.6-1.61.5-0.9-0.00.80.20.20.50.01.2
Time in novel zone, hab. session 10.50.52.00.70.11.4-1.40.50.3-0.40.10.1-0.90.2-0.7
Total zone transitions, hab. session 10.20.30.70.60.80.2-0.10.6-0.3-0.6-0.7-0.70.8-0.7-0.1
Total locomotion distance, hab. session 10.20.20.60.50.7-0.30.30.3-0.2-0.3-0.4-0.40.8-0.4-0.5
Locomotion velocity, hab. session 10.10.20.50.50.6-0.10.10.4-0.2-0.4-0.4-0.50.7-0.4-0.2
Time in familiar zone, hab. session 20.30.40.9-0.9-0.7-0.60.6-0.61.00.60.30.3-0.40.40.4
Time in novel zone, hab. session 20.00.00.20.1-0.10.2-0.3-0.0-0.40.00.20.2-0.2-0.00.2
Total zone transitions, hab. session 20.20.21.20.10.3-0.50.5-0.10.70.10.20.20.20.1-1.1
Total locomotion distance, hab. session 20.40.52.40.40.8-1.01.00.10.4-0.1-0.1-0.10.9-0.3-1.5
Locomotion velocity, hab. session 20.50.72.00.81.2-0.70.70.5-0.1-0.5-0.5-0.51.2-0.6-1.4
Novel to familiar place preference ratio0.20.20.50.30.30.3-0.30.4-0.7-0.4-0.5-0.50.5-0.70.7
Novelty place preference0.30.40.80.40.30.6-0.60.5-0.8-0.5-0.6-0.60.4-0.80.9
Time in novel zone, NPP test0.30.41.10.40.20.7-0.70.5-0.7-0.5-0.5-0.50.3-0.81.1
Total zone transitions, NPP test0.40.61.60.61.1-0.70.70.4-0.3-0.4-0.6-0.61.3-0.6-0.9
Total locomotion distance, NPP test0.60.93.40.10.7-1.71.7-0.40.00.30.20.20.90.2-1.9
Locomotion velocity, NPP test0.81.14.30.31.0-1.81.8-0.2-0.10.10.00.01.3-0.0-2.1
Intraocular pressure0.61.02.1-1.1-0.6-1.41.4-1.01.21.01.01.0-0.20.9-0.3
Delta distance traveled before/after self-admin0.70.73.7-0.3-0.91.2-1.30.0-0.4-0.0-0.2-0.1-0.9-0.21.9
Delta ambulatory time before/after self-admin0.40.72.70.0-0.51.4-1.50.3-0.4-0.3-0.3-0.3-0.7-0.41.6
Parametrial fat weight3.17.210.3-2.4-2.2-2.52.6-2.73.22.73.03.0-2.33.2-2.2
Pavlov. Cond. lever latency6.07.510.1-3.1-3.2-2.02.1-3.03.23.02.92.9-3.02.9-0.6
Pavlov. Cond. magazine entry latency5.16.57.92.42.32.5-2.52.7-2.8-2.7-2.8-2.82.3-2.81.9
Pavlov. Cond. change in total contacts3.13.44.11.81.61.9-1.92.0-2.0-2.0-2.0-2.01.5-1.91.4
Pavlov. Cond. index score6.68.410.23.13.12.5-2.53.2-3.2-3.2-3.1-3.12.9-3.11.1
Pavlov. Cond. latency score7.19.011.03.23.22.6-2.63.3-3.2-3.3-3.2-3.23.0-3.21.1
Pavlov. Cond. lever contacts4.75.68.82.93.01.7-1.72.6-2.6-2.6-2.4-2.32.6-2.5-0.2
Pavlov. Cond. magazine entry number3.24.15.1-1.9-1.9-1.91.9-2.22.22.22.32.2-1.82.2-1.4
Pavlov. Cond. intertrial magazine entries2.83.36.3-2.0-1.5-2.52.5-2.11.52.01.71.6-0.91.8-0.9
Pavlov. Cond. lever-magazine prob. diff.6.48.010.13.03.12.3-2.33.1-3.2-3.1-3.1-3.12.9-3.01.1
Pavlov. Cond. response bias4.65.77.42.52.62.0-2.02.6-2.7-2.6-2.6-2.62.4-2.50.9
Pavlov. Cond. lever latency0.20.31.50.70.60.5-0.40.40.2-0.40.00.0-0.1-0.0-1.2
Pavlov. Cond. magazine entry latency0.20.20.40.50.50.3-0.30.5-0.6-0.5-0.4-0.40.5-0.50.3
Pavlov. Cond. change in total contacts0.10.22.2-0.4-0.50.2-0.3-0.1-0.30.1-0.1-0.1-0.1-0.21.5
Pavlov. Cond. index score0.10.21.1-0.0-0.00.2-0.30.2-0.6-0.2-0.3-0.40.3-0.41.0
Pavlov. Cond. latency score0.10.11.0-0.2-0.20.1-0.1-0.0-0.40.0-0.1-0.20.1-0.21.0
Pavlov. Cond. lever contacts0.20.21.1-0.7-0.6-0.40.4-0.5-0.10.40.10.1-0.10.11.0
Pavlov. Cond. magazine entry number0.00.00.1-0.0-0.10.3-0.30.10.0-0.1-0.1-0.1-0.10.00.1
Pavlov. Cond. intertrial magazine entries0.92.12.61.51.41.5-1.51.6-1.3-1.6-1.6-1.61.2-1.50.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.8-0.1-0.10.1-0.10.1-0.5-0.1-0.2-0.30.2-0.30.9
Pavlov. Cond. response bias0.20.20.90.00.2-0.0-0.00.2-0.7-0.2-0.5-0.50.5-0.50.9
Time in closed arm before self-admin0.10.20.60.40.20.8-0.70.4-0.2-0.4-0.2-0.2-0.0-0.10.2
Time in closed arm after self-admin0.10.10.2-0.1-0.2-0.20.1-0.20.40.20.30.3-0.30.3-0.4
Time in open arm before self-admin1.11.42.20.80.91.0-1.01.1-1.5-1.1-1.3-1.31.1-1.31.4
Time in open arm after self-admin0.20.21.4-0.0-0.10.3-0.40.1-0.7-0.2-0.4-0.40.2-0.41.2
Bone: periosteal estimation0.41.04.60.9-0.02.1-2.10.70.2-0.6-0.0-0.1-1.20.2-0.2
Bone: periosteal perimeter0.71.54.01.50.92.0-1.91.4-0.9-1.3-0.9-0.90.1-0.8-0.0
Bone: post-yield work0.30.51.91.10.70.8-0.80.60.2-0.60.0-0.1-0.1-0.0-1.4
Progressive ratio test 1 active lever presses0.00.10.2-0.2-0.1-0.50.4-0.3-0.40.30.20.20.00.20.0
Progressive ratio test 1 breakpoint0.00.10.2-0.1-0.1-0.40.4-0.3-0.40.20.20.20.00.20.0
Progressive ratio test 1 inactive lever presses0.51.32.6-1.0-0.7-1.61.6-1.21.01.21.11.1-0.51.1-1.0
Progressive ratio test 2 active lever presses0.10.10.5-0.10.2-0.70.7-0.1-0.40.1-0.2-0.20.6-0.20.4
Progressive ratio test 2 breakpoint0.10.20.5-0.20.1-0.70.7-0.1-0.40.1-0.2-0.20.6-0.20.5
Progressive ratio test 2 inactive lever presses0.10.20.90.60.6-0.10.10.3-0.9-0.3-0.4-0.40.6-0.4-0.2
Incentive Sensitization - Responses0.20.51.00.50.70.1-0.10.6-0.6-0.6-1.0-1.01.0-1.00.8
Incentive Sensitization - Breakpoint0.20.40.90.30.6-0.10.10.4-0.4-0.5-0.8-0.80.9-0.80.6
Sum of active levers in priming session hrs 5-60.30.31.20.50.30.4-0.50.4-1.1-0.5-0.6-0.50.4-0.40.6
Progressive ratio1.34.07.9-2.1-2.6-0.30.4-1.92.82.02.22.2-2.82.00.0
Food seeking constrained by brief footshock0.10.20.5-0.5-0.5-0.40.4-0.5-0.10.40.30.3-0.20.10.7
Seeking ratio, punishment vs. effort1.53.36.81.82.10.7-0.71.7-2.6-1.8-2.0-2.02.3-2.00.7
Retroperitoneal fat weight0.41.73.1-1.0-0.8-1.71.7-1.31.21.31.21.2-0.71.6-1.5
Reaction time number correct0.93.14.3-2.1-2.1-1.41.4-1.91.62.01.91.9-1.82.0-0.0
Reaction time mean minus median0.42.74.01.92.01.1-1.11.8-1.7-1.8-1.8-1.81.8-1.80.0
Reaction time mean minus median AUC0.32.33.81.71.90.5-0.61.5-1.9-1.6-1.6-1.61.9-1.5-0.1
Reaction time num false alarms0.81.42.11.21.11.4-1.41.3-0.9-1.3-1.2-1.30.8-1.20.6
Reaction time num false alarms AUC0.92.24.01.41.12.0-1.91.6-1.1-1.6-1.5-1.50.7-1.51.0
Reaction time trials correct on left0.93.14.3-2.1-2.1-1.41.4-1.91.62.01.91.9-1.82.0-0.0
Reaction time trials on left0.93.04.1-2.0-2.0-1.31.3-1.91.61.91.91.8-1.82.0-0.0
Reaction time mean1.02.34.82.12.20.7-0.71.6-1.4-1.6-1.3-1.31.7-1.3-1.4
Reaction time mean AUC0.92.14.52.02.10.6-0.61.5-1.4-1.6-1.3-1.31.7-1.2-1.3
Median of all reaction times0.81.32.91.61.70.3-0.31.1-0.9-1.1-0.8-0.81.2-0.7-1.6
Reaction time omissions0.81.42.71.61.70.7-0.71.3-0.9-1.3-1.1-1.11.2-1.1-1.0
Reaction time false alarm rate4.05.67.22.52.22.7-2.62.6-2.1-2.6-2.5-2.51.7-2.61.0
Reaction time premature initiation rate0.40.61.2-0.5-0.7-0.50.4-0.80.80.81.11.0-0.91.0-0.8
Reaction time premature initiations1.03.04.5-1.7-1.9-1.11.0-1.81.71.82.12.0-2.02.1-0.7
Std. dev. reaction times1.34.35.82.42.41.8-1.82.3-2.2-2.3-2.2-2.22.0-2.20.2
Reaction time trials completed0.93.04.1-2.0-2.0-1.31.3-1.91.61.91.91.8-1.82.0-0.0
Reaction time trials AUC0.93.04.0-2.0-2.0-1.41.4-1.91.71.91.91.9-1.82.0-0.2
Run reversals in cocaine runway, females0.91.11.6-1.1-0.9-1.31.2-1.20.81.11.21.2-0.61.0-0.3
Run reversals in cocaine runway, males0.50.50.80.90.90.6-0.60.8-0.7-0.8-0.7-0.70.7-0.7-0.1
Latency to leave start box in cocaine runway0.81.21.91.41.40.6-0.71.1-1.0-1.1-1.1-1.01.1-1.1-0.9
Latency to leave start box in cocaine runway, F0.60.71.31.11.10.3-0.30.8-0.9-0.8-0.9-0.91.0-1.0-0.7
Latency to leave start box in cocaine runway, M0.20.20.40.60.50.5-0.50.5-0.2-0.5-0.4-0.20.2-0.4-0.6
Std. dev. time between licks in bursts1.93.56.22.51.92.5-2.42.2-1.4-2.2-1.6-1.61.0-1.7-0.1
Total sessions with >9 infusions0.10.21.2-0.4-0.4-0.20.1-0.2-0.70.20.00.00.00.01.1
Short access day 1 total inactive lever presses0.20.31.70.70.50.3-0.40.4-1.3-0.5-0.5-0.50.4-0.5-0.1
Short access day 10 total inactive lever presses0.10.41.00.80.90.00.00.60.1-0.6-0.6-0.60.7-0.6-1.0
Short access day 1 total infusions0.10.21.90.20.2-0.1-0.00.1-1.4-0.2-0.3-0.30.5-0.30.6
Short access day 10 total infusions0.20.31.0-0.5-0.3-1.00.9-0.5-0.30.50.20.20.20.20.3
Short access total infusions0.10.20.8-0.3-0.2-0.70.6-0.4-0.90.30.10.10.20.10.5
Short access day 1 locomotion0.40.61.40.81.10.1-0.10.8-0.6-0.8-0.9-0.91.2-0.9-0.1
Short access day 10 total locomotion0.10.62.50.5-0.11.6-1.50.50.4-0.40.10.1-1.00.10.0
Short access total locomotion0.10.10.20.40.20.5-0.50.2-0.0-0.20.10.1-0.20.1-0.4
One hour access (0.3 mA shock)0.91.12.80.91.3-0.00.11.0-0.7-1.0-1.3-1.31.7-1.30.2
Compulsive drug intake2.23.36.32.42.51.4-1.22.1-0.4-2.0-1.8-1.81.7-1.8-1.7
One hour access (shock baseline)0.30.91.9-1.3-0.9-1.41.3-1.0-0.11.00.60.6-0.10.61.2
Social response proportion0.20.20.80.4-0.10.8-0.90.2-0.3-0.2-0.00.0-0.70.2-0.3
Social responses0.30.31.30.4-0.11.1-1.10.4-0.5-0.3-0.4-0.4-0.5-0.20.5
Social time2.13.35.62.42.11.8-1.72.1-1.2-2.0-1.9-1.91.4-1.8-0.9
Soleus weight1.64.69.83.12.33.1-3.02.5-1.0-2.5-1.2-1.20.6-1.3-1.5
Bone: stiffness0.71.22.2-1.1-1.0-0.90.9-1.11.51.11.11.1-1.11.3-0.9
Tibialis anterior weight0.31.01.6-1.3-1.1-1.11.1-1.21.11.20.80.8-0.71.0-0.0
Time to tail flick, vehicle, before self-admin0.20.30.70.40.80.00.20.60.5-0.5-0.5-0.50.7-0.4-0.8
Time to tail flick, vehicle, after self-admin0.51.01.31.11.10.9-0.81.1-1.1-1.1-1.1-1.11.0-1.00.3
Time to tail flick, test, before self-admin0.20.21.1-0.10.00.3-0.30.30.1-0.2-0.4-0.40.3-0.51.0
Time to tail flick, test, after self-admin0.80.92.20.50.9-0.20.20.6-1.0-0.7-1.1-1.11.5-1.31.2
Delta time to tail flick, vehicle, before/after SA0.30.32.00.00.1-0.40.30.0-1.4-0.1-0.3-0.30.6-0.40.8
Delta time to tail flick, test, before/after SA0.30.41.7-0.20.1-1.31.3-0.50.10.50.40.40.40.2-0.7
Tibia length0.51.32.90.7-0.31.7-1.70.21.4-0.20.80.8-1.71.1-1.3
Ambulatory time before self-admin0.00.10.50.00.2-0.30.3-0.10.60.10.20.2-0.00.2-0.7
Ambulatory time after self-admin0.20.30.9-0.1-0.60.8-0.8-0.10.60.10.20.2-0.90.10.4
Bone: tissue strength0.50.60.9-0.6-0.6-0.80.7-0.80.60.80.80.8-0.71.0-0.8
Total heroin consumption0.20.20.40.50.40.6-0.60.5-0.3-0.5-0.6-0.60.2-0.30.2
Bone: trabecular number0.61.25.4-0.80.1-2.32.3-0.80.30.80.40.31.00.2-0.7
Bone: trabecular spacing0.60.93.90.4-0.42.0-1.90.50.1-0.40.20.2-1.30.30.3
Bone: trabecular thickness0.81.24.5-0.9-0.2-2.12.1-1.00.61.00.60.60.40.5-0.9
Bone: trabecular tissue density0.40.73.20.2-0.11.2-1.20.6-0.7-0.6-0.6-0.6-0.0-0.81.8
Water consumed over 24 hours0.20.40.70.80.70.8-0.80.8-0.6-0.8-0.7-0.70.4-0.5-0.1
Number of responses in last shaping day1.72.15.41.50.82.3-2.31.5-1.6-1.5-1.3-1.30.2-1.20.8