Hub : Genes

Lrrc4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Lrrc4b 0.06 0.04 6.9e-06 0.07 0.07 0.07 0.07 3.0e-06 3.4e-06 1.7e-06 4.0e-06
2 BLA mRNA stability Lrrc4b 0.13 0.07 1.4e-07 0.11 0.12 0.1 0.1 1.2e-06 1.1e-06 3.9e-06 3.7e-06
3 IC mRNA stability Lrrc4b 0.07 0.05 2.5e-03 0.06 0.05 0.03 0.04 1.1e-03 3.5e-03 2.7e-02 8.6e-03
4 NAcc mRNA stability Lrrc4b 0.06 0.03 1.1e-10 0.06 0.07 0.07 0.06 1.7e-09 1.3e-10 2.0e-10 4.2e-10
5 Brain mRNA stability Lrrc4b 0.06 0.04 2.8e-06 0.06 0.06 0.04 0.05 2.9e-06 7.7e-06 9.7e-05 8.9e-06
6 LHb mRNA stability Lrrc4b 0.15 0.09 2.5e-03 0.13 0.09 0.08 0.1 4.6e-04 4.6e-03 6.5e-03 1.8e-03
7 Brain intron excision ratio chr1_104058697_104074388 0.04 0.03 2.5e-03 0.02 0.03 0.02 0.02 1.2e-02 1.6e-03 3.8e-03 1.0e-02
8 pVTA gene expression Lrrc4b 0.06 0.04 1.6e-04 0.06 0.05 0.06 0.05 2.9e-05 6.1e-05 1.2e-05 4.7e-05
9 Brain intron excision ratio chr1_104072172_104074388 0.04 0.03 2.8e-03 0.02 0.03 0.02 0.02 1.1e-02 1.5e-03 3.2e-03 8.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.50.80.40.60.90.40.80.7-0.90.90.9
Area under the delay curve0.50.61.3-0.9-0.7-0.0-0.4-1.0-0.60.8-1.1-0.8
BMI with tail0.41.41.80.91.01.30.71.31.3-1.31.31.3
BMI without tail0.10.20.6-0.20.10.2-0.00.40.2-0.60.70.6
Body weight0.72.95.3-2.3-1.9-1.9-2.0-1.7-1.61.1-1.0-1.1
Weight adjusted by age0.00.00.20.40.1-0.10.10.20.30.0-0.2-0.0
Bone surface1.22.13.50.41.21.61.11.31.3-1.81.91.8
Bone volume0.50.91.80.00.60.90.40.90.7-1.31.41.3
Breakpoint value in progressive ratio session0.50.61.20.10.50.70.20.60.9-1.11.11.1
Number of licking bursts0.20.31.20.70.80.31.10.50.2-0.10.10.0
Context. condit. distance diff. score8.19.813.63.03.53.23.73.13.2-2.82.72.8
Locomotion velocity, session 11.81.94.42.11.61.31.91.41.4-0.60.50.5
Locomotion distance, session 13.84.85.72.32.32.22.12.42.3-2.12.12.1
Locomotion velocity, session 20.60.72.11.51.00.71.11.00.8-0.30.30.3
Locomotion distance, session 20.60.81.21.01.00.71.01.10.9-0.80.90.8
Locomotion velocity, session 30.81.02.51.61.20.71.61.00.8-0.10.20.1
Locomotion distance, session 30.10.10.20.30.20.30.00.40.2-0.30.40.3
Stereotopy head waving bouts, day 32.12.43.31.81.81.31.81.81.5-1.31.41.3
Stereotopy head waving duration, day 32.32.84.11.91.91.62.01.81.6-1.31.41.3
Locomotion velocity, session 70.30.30.90.1-0.1-0.20.4-0.5-0.40.9-0.9-0.9
Locomotion distance, session 70.20.30.40.30.60.60.60.50.4-0.50.50.5
Stereotopy head waving bouts, day 70.20.20.50.20.1-0.00.4-0.3-0.20.6-0.7-0.7
Stereotopy head waving duration, day 70.10.20.50.30.10.10.4-0.2-0.20.6-0.7-0.6
Locomotion velocity, session 83.94.610.03.22.52.22.72.22.2-1.10.91.1
Locomotion distance, session 89.413.718.44.04.13.84.33.73.9-3.13.03.1
Degree of sensitization distance0.20.20.40.40.50.40.70.30.4-0.30.20.3
Degree of sensitization stereotypy0.91.01.9-0.6-0.8-0.6-0.4-1.1-0.91.3-1.4-1.3
Conditioned locomotion0.10.10.2-0.2-0.1-0.40.0-0.4-0.10.3-0.4-0.3
Cocaine response after cond. corrected1.82.23.4-1.1-1.7-1.4-1.9-1.4-1.41.4-1.5-1.4
Cocaine response after cond. not corrected1.51.82.6-1.0-1.5-1.3-1.6-1.3-1.31.3-1.4-1.3
Cocaine response before conditioning0.20.30.80.50.70.60.90.40.5-0.20.10.2
Saline control response0.10.20.5-0.5-0.4-0.7-0.3-0.3-0.60.4-0.2-0.4
Bone: connectivity density2.03.14.61.31.82.21.81.71.8-1.71.61.7
Bone: cortical apparent density1.21.72.7-1.7-1.4-1.6-1.4-1.4-1.30.9-0.8-0.9
Bone: cortical area0.30.51.3-1.2-0.8-0.5-1.0-0.6-0.70.1-0.0-0.1
Bone: cortical porosity0.40.41.11.00.4-0.40.70.20.10.7-0.8-0.7
Bone: cortical porosity0.50.51.81.30.8-0.01.10.50.50.4-0.6-0.4
Bone: cortical thickness0.71.11.3-0.9-1.1-1.1-1.1-1.1-1.11.0-1.0-1.0
Bone: cortical thickness0.10.10.20.40.30.20.10.40.3-0.40.40.4
Bone: cortical tissue density1.31.72.7-1.7-1.4-1.6-1.4-1.4-1.30.9-0.8-0.9
Condit. Reinf. active minus inactive responses0.00.00.1-0.3-0.1-0.2-0.2-0.10.0-0.10.10.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.1-0.00.30.0-0.10.2-0.0-0.10.0
Condit. Reinf. active responses0.20.20.6-0.8-0.5-0.7-0.5-0.5-0.50.3-0.2-0.3
Condit. Reinf. inactive responses0.60.81.5-1.2-0.9-1.2-0.9-0.7-1.10.5-0.2-0.5
Incentive salience index mean0.00.00.1-0.2-0.2-0.2-0.2-0.1-0.0-0.0-0.00.0
Condit. Reinf. lever presses0.91.31.8-1.1-1.2-1.3-1.2-1.1-1.21.0-0.9-1.0
Condit. Reinf. active minus inactive responses0.20.30.6-0.8-0.3-0.7-0.0-0.6-0.70.3-0.2-0.4
Condit. Reinf. active-inactive response ratio0.20.20.4-0.2-0.3-0.6-0.1-0.4-0.60.6-0.5-0.6
Condit. Reinf. active responses0.20.31.3-1.1-0.4-0.6-0.2-0.5-0.6-0.00.20.0
Condit. Reinf. inactive responses0.40.51.3-0.9-0.10.1-0.30.20.1-1.01.11.0
Condit. Reinf. lever presses0.20.31.3-1.1-0.1-0.3-0.0-0.1-0.3-0.60.90.6
Condit. Reinf. lever reinforcers received0.20.31.6-1.3-0.4-0.6-0.3-0.4-0.5-0.20.40.2
Conditioned reinforcement - actives0.10.10.10.30.2-0.10.10.40.4-0.30.30.3
Conditioned reinforcement - inactives0.00.00.2-0.30.1-0.40.3-0.20.10.1-0.0-0.1
Conditioned locomotion0.70.91.51.10.90.50.81.10.9-0.91.21.0
Patch foraging indifference point 0 sec0.40.72.7-1.6-0.5-0.90.1-0.9-1.10.5-0.3-0.6
Patch foraging indifference point AUC0.91.31.61.01.21.21.21.21.1-1.11.11.1
Delay disc. indifference point, 0s delay0.50.60.70.60.80.70.80.80.5-0.80.80.8
Delay disc. indifference point, 16s delay1.31.42.2-1.1-1.1-0.8-0.8-1.3-1.31.3-1.5-1.3
Delay disc. indifference point, 2s delay2.32.64.31.31.72.11.81.51.6-1.51.31.5
Delay disc. indifference point, 24s delay0.10.10.30.10.20.30.6-0.20.30.2-0.6-0.2
Delay disc. indifference point, 4s delay0.40.40.8-0.9-0.7-0.1-0.6-0.8-0.60.6-0.7-0.6
Delay disc. indifference point, 8s delay2.02.33.9-1.6-1.5-0.8-1.3-1.8-1.21.6-2.0-1.6
Indifference point function ln k0.00.10.2-0.5-0.1-0.0-0.2-0.0-0.2-0.30.40.3
Indifference point function log k0.00.10.2-0.5-0.1-0.0-0.2-0.0-0.2-0.30.40.3
Patch foraging total patch changes 0 sec0.40.82.6-1.6-0.6-0.90.1-1.0-1.20.7-0.5-0.7
Patch foraging total patch changes 12 sec0.10.10.3-0.60.10.00.10.1-0.1-0.50.60.5
Patch foraging total patch changes 18 sec1.42.15.71.01.81.32.41.31.1-1.21.21.1
Patch foraging total patch changes 24 sec2.23.74.91.21.92.21.91.81.8-2.12.22.1
Patch foraging total patch changes 6 sec0.10.10.4-0.60.0-0.10.4-0.2-0.3-0.00.1-0.0
Patch foraging time to switch 0 sec0.71.53.0-0.0-1.0-1.2-0.9-0.9-1.11.7-1.7-1.6
Patch foraging water rate 0 sec0.30.61.6-0.10.80.81.20.40.6-0.70.80.7
Patch foraging water rate 12 sec0.40.91.80.30.91.31.10.80.8-1.01.01.0
Patch foraging water rate 18 sec0.10.21.0-0.10.21.00.3-0.20.3-0.30.20.3
Patch foraging water rate 24 sec1.31.92.60.91.31.61.21.21.4-1.51.51.5
Patch foraging water rate 6 sec1.01.53.10.11.01.50.90.90.9-1.61.81.6
Seeking ratio, delayed vs. immediate footshock0.40.40.70.70.50.90.20.70.7-0.70.60.7
Distance traveled before self-admin0.81.11.80.51.00.80.91.11.0-1.31.11.3
Distance traveled after self-admin0.20.20.70.40.20.70.10.20.8-0.4-0.00.4
Extensor digitorum longus weight2.28.510.23.13.13.03.12.93.2-2.62.42.6
Bone: elastic displacement1.82.03.71.91.71.61.91.31.6-0.80.50.8
Bone: elastic work0.30.40.90.30.50.90.30.60.8-0.80.70.8
Bone: endosteal estimation0.81.74.1-0.10.61.40.21.20.9-1.92.01.9
Bone: endosteal perimeter0.30.71.9-0.40.20.9-0.00.60.4-1.21.41.2
Epididymis fat weight0.00.10.30.50.2-0.30.10.30.30.0-0.1-0.0
Delta time in closed arm before/after self-admin1.31.22.2-0.6-0.9-1.5-0.7-0.8-1.21.3-1.2-1.3
Delta time in open arm before/after self-admin0.10.10.20.20.30.50.30.40.2-0.50.40.4
Diff in mean of infusions in LGA sessions0.60.71.10.60.90.71.10.70.8-0.91.00.9
Delay discount exponential model param0.60.71.50.90.80.10.51.00.6-0.81.20.8
Extinction: sum of active levers before priming0.40.51.10.20.1-0.1-0.50.60.7-1.00.91.1
Active lever presses in extinction session 60.90.91.40.70.70.80.21.11.0-1.21.01.2
Bone: final force0.10.20.7-0.8-0.6-0.2-0.9-0.4-0.3-0.10.10.1
Bone: final moment0.30.51.2-1.1-0.9-0.5-1.1-0.7-0.60.1-0.1-0.1
Food consumed during 24 hour testing period0.81.11.6-1.3-1.0-1.1-0.8-1.2-1.21.0-0.9-1.0
Glucose0.20.40.90.3-0.3-0.4-0.2-0.3-0.60.9-1.0-0.9
Heart weight0.60.91.50.20.81.20.60.71.0-1.21.11.2
Delay discount hyperbolic model param0.30.30.90.70.5-0.20.30.70.3-0.60.90.6
Intermittent access intake day 1-15 change1.53.05.21.01.51.71.31.71.6-2.12.32.1
Intermittent access intake escalation1.12.34.80.71.21.40.91.41.3-1.92.21.9
Intermittent access intake escalation 20.30.30.9-0.00.30.30.20.40.5-0.80.90.8
Intermitt. access day 1 inactive lever presses0.31.21.90.41.10.81.20.91.2-1.31.41.3
Intermitt. access day 15 inactive lever presses1.63.46.6-2.6-1.9-1.6-1.6-2.2-1.81.5-1.5-1.5
Intermitt. access escalation Index0.30.51.0-0.4-0.8-0.8-1.0-0.6-0.60.6-0.6-0.6
Intermittent access day 1 total infusions1.52.43.6-1.5-1.5-1.9-1.3-1.6-1.51.5-1.5-1.5
Intermittent access day 15 total infusions0.20.20.9-0.9-0.5-0.5-0.5-0.4-0.5-0.00.30.0
Intermittent access terminal intake (last 3 days)0.10.10.2-0.5-0.1-0.4-0.1-0.1-0.1-0.30.40.3
Intermittent access total infusions0.91.01.7-1.2-1.1-1.3-1.1-1.0-1.10.8-0.7-0.8
Intermittent access day 1 locomotion0.10.10.3-0.5-0.4-0.5-0.3-0.4-0.40.3-0.0-0.3
Intermittent access day 15 total locomotion1.42.54.11.11.51.41.41.61.5-1.72.01.7
Intermittent access total locomotion0.10.10.6-0.00.1-0.10.00.30.2-0.50.80.5
Intermittent access standard deviation0.00.00.20.10.10.10.20.10.1-0.10.40.1
Left kidney weight4.219.327.0-5.2-5.0-4.7-5.2-4.4-4.43.5-3.3-3.4
Right kidney weight4.620.828.2-5.3-5.1-4.5-5.3-4.7-4.73.8-3.6-3.7
Cocaine induced anxiety0.40.50.9-0.4-0.7-0.5-0.7-0.8-0.60.8-1.0-0.8
Post-drug Anxiety0.30.30.80.90.30.70.40.00.20.5-0.7-0.6
Baseline Anxiety0.70.81.91.41.01.01.10.90.9-0.30.20.3
Tail length1.76.512.0-3.5-2.8-2.7-2.6-2.7-2.81.8-1.6-1.8
Length with tail2.29.815.4-3.9-3.5-3.4-3.5-3.3-3.22.3-2.2-2.3
Length without tail0.82.63.2-1.6-1.6-1.8-1.5-1.7-1.61.6-1.6-1.6
Times rat made contact with spout0.10.20.4-0.10.0-0.40.4-0.3-0.60.5-0.4-0.6
Lifetime Intake2.73.34.5-2.0-1.9-2.1-1.9-1.9-1.91.5-1.4-1.5
Liver weight, left0.10.20.5-0.3-0.1-0.1-0.50.30.0-0.60.70.7
Liver weight, right0.00.10.2-0.4-0.2-0.2-0.1-0.4-0.20.3-0.2-0.3
Locomotor activity0.91.52.2-1.5-1.4-1.0-1.3-1.5-1.21.0-1.0-1.0
Locomotor testing distance0.10.30.7-0.9-0.6-0.1-0.7-0.6-0.50.2-0.2-0.2
Locomotor testing rearing0.30.61.3-1.1-0.9-0.6-1.0-0.8-0.90.4-0.3-0.4
Locomotion in novel chamber1.51.93.4-1.5-1.6-1.6-1.8-1.3-1.11.0-1.0-1.0
Locomotion in novel chamber post-restriction0.71.11.90.70.81.00.51.21.0-1.41.31.4
Fecal boli incidents, locomotor time 11.11.62.5-1.0-1.1-1.2-0.7-1.5-1.01.6-1.5-1.6
Change in fecal boli incidents, locomotor task0.00.00.20.30.20.40.20.20.10.00.0-0.0
Time >=10cm from walls, locomotor time 15.15.47.8-2.7-2.7-2.4-2.8-2.5-2.31.9-1.6-1.9
Bouts of movement, locomotor time 13.13.54.5-1.8-2.1-1.6-2.1-1.9-1.91.8-1.7-1.8
Total resting periods, locomotor time 12.73.03.5-1.5-1.9-1.6-1.9-1.8-1.71.8-1.6-1.8
Rest time, locomotor task time 10.10.20.50.3-0.0-0.70.1-0.2-0.20.6-0.4-0.6
Distance moved, locomotor task time 13.65.46.42.02.22.51.82.52.3-2.52.52.5
Vertical activity count, locomotor time 10.10.10.4-0.6-0.20.3-0.30.10.0-0.50.30.5
Time >=10cm from walls, locomotor time 20.91.42.3-1.0-1.1-1.5-1.0-1.1-1.01.2-1.3-1.2
Bouts of movement, locomotor time 20.10.20.6-0.8-0.4-0.3-0.6-0.2-0.4-0.30.40.3
Total resting periods, locomotor time 20.10.20.7-0.8-0.5-0.3-0.7-0.3-0.3-0.20.30.3
Rest time, locomotor task time 20.50.61.0-0.7-0.9-0.8-1.0-0.9-0.60.7-0.5-0.7
Distance moved, locomotor task time 21.72.12.51.31.51.41.51.61.2-1.51.51.5
Vertical activity count, locomotor time 20.20.20.6-0.5-0.3-0.3-0.1-0.5-0.50.5-0.8-0.6
Light reinforcement 10.20.60.90.20.80.80.90.60.8-0.80.80.8
Light reinforcement 20.20.41.01.00.70.61.00.50.50.0-0.0-0.0
Bone: marrow area0.81.84.1-0.00.71.40.31.21.0-1.92.01.9
Bone: maximum diameter0.30.62.0-1.4-1.0-0.4-1.1-0.7-0.90.2-0.0-0.1
Bone: maximum force0.40.71.5-0.40.10.7-0.40.50.6-1.21.21.2
Bone: maximum moment0.30.51.1-0.6-0.20.4-0.70.20.3-1.01.01.1
Mean time between licks in bursts0.00.10.30.3-0.00.00.1-0.2-0.30.5-0.5-0.5
Mean num. licks in bursts0.00.10.2-0.4-0.3-0.1-0.4-0.2-0.1-0.20.20.2
Cd content in liver1.51.72.5-1.6-1.4-1.6-1.3-1.3-1.51.1-0.9-1.1
Co content in liver0.40.40.6-0.5-0.7-0.6-0.7-0.7-0.70.7-0.7-0.7
Cu content in liver1.41.72.21.21.31.51.11.31.3-1.31.31.3
Fe content in liver2.22.74.31.41.81.62.11.61.6-1.51.51.4
K content in liver0.20.20.5-0.0-0.1-0.10.3-0.5-0.30.7-0.7-0.7
Mg content in liver0.60.61.3-0.3-0.6-0.5-0.3-0.9-0.61.0-1.1-1.0
Mn content in liver0.10.10.20.3-0.00.0-0.0-0.1-0.10.4-0.5-0.4
Na content in liver0.10.10.10.40.30.30.20.30.3-0.20.10.2
Rb content in liver2.12.44.81.41.81.62.21.41.6-1.21.21.2
Se content in liver0.20.20.80.10.40.90.30.20.6-0.50.40.5
Sr content in liver0.20.10.4-0.00.30.10.30.40.1-0.50.60.5
Zn content in liver0.20.20.4-0.6-0.5-0.3-0.3-0.6-0.40.4-0.4-0.4
Bone: minimum diameter1.32.34.50.31.11.60.71.31.3-2.02.12.0
Time in familiar zone, hab. session 10.10.10.3-0.5-0.2-0.0-0.2-0.2-0.2-0.00.10.0
Time in novel zone, hab. session 10.10.10.40.60.40.20.50.20.5-0.0-0.10.0
Total zone transitions, hab. session 10.81.11.91.41.11.11.11.01.2-0.70.60.7
Total locomotion distance, hab. session 10.60.81.10.91.00.91.00.81.1-0.80.70.8
Locomotion velocity, hab. session 10.10.20.30.60.50.40.50.40.6-0.30.20.3
Time in familiar zone, hab. session 20.40.41.5-1.2-0.3-0.2-0.5-0.2-0.2-0.70.90.7
Time in novel zone, hab. session 21.01.02.51.61.11.11.21.01.2-0.50.40.5
Total zone transitions, hab. session 21.51.92.61.41.61.11.61.51.4-1.31.31.2
Total locomotion distance, hab. session 21.31.82.11.01.41.01.41.31.4-1.41.51.4
Locomotion velocity, hab. session 20.50.71.20.71.00.51.10.90.8-0.80.80.8
Novel to familiar place preference ratio0.50.61.2-0.2-0.4-0.60.0-0.8-0.71.0-1.1-1.1
Novelty place preference0.30.30.8-0.0-0.1-0.50.3-0.5-0.50.8-0.9-0.9
Time in novel zone, NPP test0.20.20.5-0.0-0.0-0.30.4-0.4-0.30.7-0.7-0.7
Total zone transitions, NPP test1.72.53.81.91.61.51.31.81.7-1.41.41.5
Total locomotion distance, NPP test4.25.86.62.32.42.32.12.62.6-2.52.52.5
Locomotion velocity, NPP test3.04.25.02.22.11.91.82.22.2-2.02.02.0
Intraocular pressure5.17.310.7-2.7-3.1-2.5-3.3-2.8-2.62.4-2.5-2.4
Delta distance traveled before/after self-admin0.40.50.8-0.4-0.7-0.4-0.7-0.9-0.10.8-0.9-0.8
Delta ambulatory time before/after self-admin0.10.10.30.1-0.1-0.00.0-0.40.20.5-0.6-0.5
Parametrial fat weight1.73.95.6-1.1-1.8-1.7-1.6-1.9-2.12.4-2.4-2.4
Pavlov. Cond. lever latency0.70.81.20.61.01.11.10.80.9-0.90.90.9
Pavlov. Cond. magazine entry latency0.30.41.0-0.8-0.7-1.0-0.6-0.6-0.70.4-0.3-0.4
Pavlov. Cond. change in total contacts0.50.50.7-0.6-0.7-0.8-0.6-0.7-0.70.7-0.7-0.7
Pavlov. Cond. index score1.51.93.0-1.2-1.4-1.7-1.3-1.4-1.41.3-1.3-1.3
Pavlov. Cond. latency score1.62.03.1-1.3-1.5-1.8-1.5-1.4-1.51.3-1.3-1.3
Pavlov. Cond. lever contacts1.11.31.8-0.9-1.2-1.3-1.3-1.1-1.11.1-1.1-1.1
Pavlov. Cond. magazine entry number0.50.61.20.70.71.10.70.70.8-0.70.70.7
Pavlov. Cond. intertrial magazine entries0.60.71.21.11.00.91.10.80.9-0.50.40.5
Pavlov. Cond. lever-magazine prob. diff.0.70.81.5-0.6-0.8-1.2-0.7-0.8-0.91.0-1.0-1.0
Pavlov. Cond. response bias1.01.22.0-0.9-1.1-1.4-1.0-1.1-1.11.2-1.1-1.1
Pavlov. Cond. lever latency0.70.91.7-0.2-0.9-1.0-0.9-0.8-0.81.2-1.3-1.2
Pavlov. Cond. magazine entry latency0.50.71.10.20.90.71.10.80.7-0.90.90.9
Pavlov. Cond. change in total contacts0.20.41.7-1.3-0.3-0.1-0.4-0.3-0.3-0.60.80.6
Pavlov. Cond. index score0.70.91.8-0.10.80.90.90.70.7-1.21.31.2
Pavlov. Cond. latency score0.70.91.50.10.90.91.00.80.8-1.11.21.1
Pavlov. Cond. lever contacts0.70.92.00.00.80.90.70.80.8-1.31.41.3
Pavlov. Cond. magazine entry number1.11.42.5-0.2-1.1-1.1-1.2-1.0-1.01.5-1.6-1.5
Pavlov. Cond. intertrial magazine entries0.30.41.2-0.4-0.5-1.1-0.5-0.6-0.70.7-0.6-0.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.5-0.20.70.70.80.60.6-1.11.21.1
Pavlov. Cond. response bias1.01.43.0-0.00.91.00.91.00.9-1.61.71.6
Time in closed arm before self-admin0.10.10.40.50.20.60.20.00.4-0.0-0.20.0
Time in closed arm after self-admin1.51.62.61.61.31.21.11.41.5-1.11.01.1
Time in open arm before self-admin0.20.20.6-0.7-0.4-0.4-0.7-0.1-0.2-0.30.60.4
Time in open arm after self-admin0.10.10.2-0.3-0.10.4-0.20.10.0-0.40.40.4
Bone: periosteal estimation0.40.82.2-0.60.10.7-0.30.60.4-1.31.51.3
Bone: periosteal perimeter0.10.20.5-0.4-0.00.5-0.30.30.1-0.60.70.7
Bone: post-yield work0.40.51.2-0.10.20.8-0.20.40.7-1.11.11.1
Progressive ratio test 1 active lever presses2.32.84.2-2.0-1.8-1.9-1.8-1.8-1.81.4-1.3-1.3
Progressive ratio test 1 breakpoint2.12.53.8-2.0-1.7-1.9-1.6-1.7-1.61.3-1.2-1.2
Progressive ratio test 1 inactive lever presses1.31.94.9-2.2-1.5-1.5-1.6-1.5-1.20.5-0.4-0.5
Progressive ratio test 2 active lever presses1.11.32.0-1.4-1.2-0.9-1.1-1.4-1.11.0-0.9-1.0
Progressive ratio test 2 breakpoint1.61.82.7-1.6-1.5-1.2-1.4-1.6-1.41.2-1.1-1.2
Progressive ratio test 2 inactive lever presses0.20.30.8-0.9-0.6-0.4-0.6-0.8-0.50.4-0.4-0.4
Incentive Sensitization - Responses0.00.00.1-0.3-0.10.4-0.1-0.30.0-0.10.20.1
Incentive Sensitization - Breakpoint0.00.00.1-0.4-0.20.3-0.1-0.3-0.10.00.1-0.0
Sum of active levers in priming session hrs 5-63.12.93.61.21.71.71.61.61.8-1.91.81.9
Progressive ratio0.30.40.7-0.8-0.5-0.7-0.2-0.6-0.80.6-0.6-0.6
Food seeking constrained by brief footshock0.60.81.3-1.2-1.0-0.8-1.1-0.9-0.80.6-0.7-0.6
Seeking ratio, punishment vs. effort0.10.10.5-0.0-0.30.2-0.70.00.3-0.30.30.3
Retroperitoneal fat weight0.83.44.7-1.4-1.8-2.2-1.8-1.7-1.91.9-1.9-1.9
Reaction time number correct3.26.17.82.32.42.82.02.62.5-2.52.42.5
Reaction time mean minus median0.30.82.00.10.70.60.50.80.6-1.31.41.3
Reaction time mean minus median AUC0.20.51.10.30.60.30.40.80.5-0.91.01.0
Reaction time num false alarms1.42.02.70.61.51.11.61.31.7-1.61.61.6
Reaction time num false alarms AUC0.30.41.10.00.70.31.00.40.8-0.60.60.6
Reaction time trials correct on left3.26.17.82.32.42.82.02.62.5-2.52.42.5
Reaction time trials on left2.85.36.92.12.22.61.92.42.4-2.42.32.4
Reaction time mean0.71.22.6-1.6-1.2-1.0-1.3-1.2-1.10.6-0.6-0.6
Reaction time mean AUC0.71.22.2-1.5-1.2-1.0-1.2-1.2-1.10.7-0.7-0.7
Median of all reaction times1.82.64.0-2.0-1.7-1.6-1.7-1.8-1.61.3-1.3-1.3
Reaction time omissions2.33.34.0-1.9-2.0-1.8-2.0-1.9-1.71.7-1.7-1.6
Reaction time false alarm rate0.20.20.6-0.8-0.2-0.70.2-0.6-0.30.4-0.4-0.5
Reaction time premature initiation rate2.33.24.2-1.3-1.7-1.9-1.4-1.8-1.82.1-2.1-2.1
Reaction time premature initiations0.20.40.7-0.2-0.5-0.5-0.5-0.6-0.50.8-0.8-0.8
Std. dev. reaction times0.10.20.7-0.8-0.3-0.1-0.4-0.2-0.2-0.30.40.3
Reaction time trials completed2.85.36.92.12.22.61.92.42.4-2.42.32.4
Reaction time trials AUC2.65.06.32.12.22.51.82.42.3-2.32.32.3
Run reversals in cocaine runway, females2.22.22.41.21.51.51.51.41.5-1.51.51.5
Run reversals in cocaine runway, males0.30.30.50.40.40.40.30.50.7-0.70.50.7
Latency to leave start box in cocaine runway8.810.011.22.83.23.02.93.33.2-3.33.23.3
Latency to leave start box in cocaine runway, F5.26.06.72.22.42.62.22.52.6-2.52.52.5
Latency to leave start box in cocaine runway, M4.23.94.71.72.11.72.02.11.8-2.22.02.1
Std. dev. time between licks in bursts0.10.10.2-0.4-0.2-0.10.0-0.4-0.30.3-0.3-0.3
Total sessions with >9 infusions5.87.18.2-2.7-2.8-2.6-2.6-2.9-2.82.5-2.5-2.5
Short access day 1 total inactive lever presses0.60.81.1-1.0-0.8-0.8-0.6-1.1-0.90.9-1.0-0.9
Short access day 10 total inactive lever presses1.33.23.91.31.91.62.01.71.9-1.91.81.8
Short access day 1 total infusions3.03.94.7-2.0-2.1-2.0-2.0-2.2-1.91.8-2.0-1.8
Short access day 10 total infusions4.86.27.3-2.7-2.6-2.5-2.6-2.6-2.62.2-2.3-2.2
Short access total infusions7.39.210.9-3.2-3.3-3.2-3.3-3.2-3.12.7-2.6-2.6
Short access day 1 locomotion1.51.83.8-1.9-1.5-1.5-1.5-1.5-1.30.8-0.6-0.8
Short access day 10 total locomotion0.20.30.70.40.0-0.80.4-0.1-0.40.8-0.6-0.8
Short access total locomotion2.02.43.0-1.4-1.5-1.7-1.2-1.5-1.71.7-1.4-1.7
One hour access (0.3 mA shock)0.00.00.1-0.30.0-0.30.2-0.10.1-0.10.20.1
Compulsive drug intake0.10.10.2-0.1-0.20.1-0.1-0.30.00.4-0.4-0.4
One hour access (shock baseline)0.10.10.3-0.5-0.2-0.6-0.2-0.2-0.3-0.00.20.0
Social response proportion3.33.76.7-1.6-1.8-2.6-1.6-1.7-2.12.0-1.8-2.0
Social responses1.72.24.0-1.3-1.3-2.0-1.1-1.3-1.71.5-1.3-1.5
Social time0.60.81.40.50.80.70.71.10.7-1.01.21.0
Soleus weight1.54.56.92.42.42.42.62.12.3-1.61.41.5
Bone: stiffness0.40.61.40.10.40.70.10.70.7-1.11.21.2
Tibialis anterior weight0.31.01.31.21.11.11.01.11.1-0.90.80.8
Time to tail flick, vehicle, before self-admin1.21.22.01.31.11.41.01.41.0-0.90.80.9
Time to tail flick, vehicle, after self-admin1.92.63.31.61.70.91.61.81.6-1.61.71.6
Time to tail flick, test, before self-admin0.40.40.90.60.60.90.70.50.7-0.50.60.5
Time to tail flick, test, after self-admin1.61.62.11.21.41.01.41.41.1-1.21.41.2
Delta time to tail flick, vehicle, before/after SA0.00.00.10.20.2-0.20.3-0.00.30.00.0-0.0
Delta time to tail flick, test, before/after SA0.00.00.20.20.2-0.40.20.3-0.1-0.10.10.1
Tibia length3.910.819.7-4.4-3.8-3.4-4.1-3.2-3.52.0-1.8-2.0
Ambulatory time before self-admin0.40.51.20.10.60.50.40.70.6-1.10.91.1
Ambulatory time after self-admin0.10.10.50.20.30.40.20.20.7-0.40.00.4
Bone: tissue strength0.30.30.4-0.6-0.6-0.3-0.7-0.6-0.50.5-0.6-0.5
Total heroin consumption0.70.81.40.90.91.21.10.81.0-0.70.80.7
Bone: trabecular number0.61.01.50.70.81.20.61.11.0-1.21.11.2
Bone: trabecular spacing0.71.01.3-0.9-1.1-1.0-1.1-0.9-1.00.9-0.9-0.9
Bone: trabecular thickness0.10.10.3-0.3-0.1-0.0-0.30.00.1-0.50.50.5
Bone: trabecular tissue density0.60.82.4-1.5-1.0-1.1-1.1-0.9-0.80.2-0.1-0.2
Water consumed over 24 hours0.30.52.10.81.00.31.50.50.4-0.10.10.0
Number of responses in last shaping day2.02.22.7-1.5-1.5-1.7-1.4-1.5-1.51.4-1.4-1.4