Lrrc36

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Lrrc36	0.26	0.24	7.4e-03	0.02	0.03	0.01	0.03	2.0e-02	6.6e-03	8.9e-02	1.6e-02
2	Brain	gene expression	Lrrc36	0.1	0.08	1.9e-07	0.06	0.07	0.06	0.06	1.9e-06	8.8e-07	2.1e-06	3.5e-06
3	Brain	alternative polyA	XM_063278125.1	0.03	0.03	1.0e-02	0.01	0.01	0	0.01	3.1e-02	1.6e-02	1.1e-01	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.1	0.2	0.2	-0.4	0.4
Area under the delay curve	0.0	0.0	0.1	-0.3	0.1	-0.1
BMI with tail	0.0	0.1	0.1	-0.0	-0.4	0.4
BMI without tail	0.0	0.1	0.3	-0.6	0.1	-0.0
Body weight	0.3	1.4	1.5	-1.2	-1.2	1.2
Weight adjusted by age	0.0	0.0	0.1	-0.3	-0.1	0.1
Bone surface	1.1	2.0	2.5	-1.0	-1.6	1.6
Bone volume	0.9	1.6	2.1	-0.9	-1.5	1.4
Breakpoint value in progressive ratio session	2.4	2.9	4.2	2.1	1.5	-1.5
Number of licking bursts	0.5	0.8	0.9	-0.7	-1.0	1.0
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	0.2	-0.2
Locomotion velocity, session 1	0.1	0.1	0.1	-0.4	-0.2	0.2
Locomotion distance, session 1	0.1	0.1	0.1	-0.1	0.3	-0.3
Locomotion velocity, session 2	0.5	0.5	0.8	0.3	0.9	-0.9
Locomotion distance, session 2	0.1	0.1	0.2	-0.1	0.4	-0.4
Locomotion velocity, session 3	0.3	0.4	0.4	0.6	0.6	-0.6
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.2	-0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	-0.6	-0.3	0.3
Stereotopy head waving duration, day 3	0.5	0.6	0.7	-0.7	-0.8	0.8
Locomotion velocity, session 7	0.1	0.1	0.4	0.6	0.0	-0.1
Locomotion distance, session 7	0.1	0.1	0.2	0.5	0.2	-0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.2	-0.4	0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.6	-0.2	-0.8	0.8
Locomotion velocity, session 8	0.2	0.3	0.8	0.9	0.1	-0.1
Locomotion distance, session 8	0.4	0.6	0.6	0.7	0.8	-0.8
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.1	0.1
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.0	-0.6	0.6
Conditioned locomotion	2.0	2.3	2.4	-1.5	-1.6	1.6
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.3	-0.6	0.6
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.1	-0.1	0.1
Cocaine response before conditioning	1.1	1.3	1.6	0.8	1.3	-1.3
Saline control response	4.9	6.5	7.3	-2.7	-2.5	2.5
Bone: connectivity density	0.1	0.2	0.5	0.7	0.2	-0.2
Bone: cortical apparent density	1.2	1.7	2.8	1.7	1.1	-1.1
Bone: cortical area	0.3	0.4	0.6	-0.5	-0.7	0.7
Bone: cortical porosity	0.1	0.2	0.2	0.1	0.5	-0.5
Bone: cortical porosity	0.1	0.1	0.2	0.1	0.5	-0.5
Bone: cortical thickness	0.1	0.2	0.2	0.2	-0.5	0.5
Bone: cortical thickness	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: cortical tissue density	1.3	1.7	2.8	1.7	1.1	-1.1
Condit. Reinf. active minus inactive responses	4.2	4.7	4.8	2.1	2.2	-2.2
Condit. Reinf. active-inactive response ratio	4.0	4.3	4.3	2.1	2.1	-2.1
Condit. Reinf. active responses	2.7	3.4	3.8	1.6	1.9	-1.9
Condit. Reinf. inactive responses	0.1	0.2	0.2	0.3	0.5	-0.5
Incentive salience index mean	2.2	2.7	2.7	1.6	1.6	-1.6
Condit. Reinf. lever presses	0.1	0.2	0.3	0.6	0.4	-0.4
Condit. Reinf. active minus inactive responses	0.7	1.0	1.0	-1.0	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.7	-0.7	-0.9	0.9
Condit. Reinf. active responses	0.4	0.6	0.7	-0.9	-0.7	0.7
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.0	0.4	-0.4
Condit. Reinf. lever presses	2.3	3.1	3.2	1.8	1.8	-1.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.3	-0.3	0.3
Conditioned reinforcement - actives	0.5	0.9	1.3	0.1	1.2	-1.1
Conditioned reinforcement - inactives	0.2	0.3	0.7	0.8	-0.2	0.2
Conditioned locomotion	0.4	0.5	0.8	-0.2	-0.9	0.9
Patch foraging indifference point 0 sec	3.1	5.8	6.6	-2.6	-2.3	2.3
Patch foraging indifference point AUC	1.9	2.8	2.8	-1.7	-1.7	1.7
Delay disc. indifference point, 0s delay	0.6	0.6	0.7	0.7	0.9	-0.9
Delay disc. indifference point, 16s delay	0.6	0.7	1.9	-1.4	-0.2	0.3
Delay disc. indifference point, 2s delay	0.1	0.2	0.2	0.4	-0.4	0.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.4	0.0	0.0
Delay disc. indifference point, 4s delay	0.4	0.5	0.8	0.9	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.4	0.1	-0.1
Indifference point function ln k	0.3	0.5	0.6	0.7	0.8	-0.7
Indifference point function log k	0.3	0.5	0.6	0.7	0.8	-0.7
Patch foraging total patch changes 0 sec	3.1	5.8	6.6	-2.6	-2.3	2.3
Patch foraging total patch changes 12 sec	3.2	4.2	4.7	-2.2	-2.0	2.0
Patch foraging total patch changes 18 sec	2.8	4.3	4.8	-2.2	-2.0	2.0
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	-0.2	-0.6	0.6
Patch foraging total patch changes 6 sec	2.0	3.0	3.3	-1.5	-1.8	1.8
Patch foraging time to switch 0 sec	0.8	1.6	1.7	1.3	1.2	-1.3
Patch foraging water rate 0 sec	1.5	3.3	3.9	-2.0	-1.7	1.7
Patch foraging water rate 12 sec	0.1	0.2	0.2	-0.3	-0.4	0.4
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.0	-0.2	0.2
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.5	-0.1	0.1
Patch foraging water rate 6 sec	0.5	0.8	1.0	-0.5	-1.0	1.0
Seeking ratio, delayed vs. immediate footshock	2.4	2.9	3.1	-1.7	-1.7	1.8
Distance traveled before self-admin	1.0	1.4	2.5	1.6	-0.9	0.9
Distance traveled after self-admin	0.1	0.1	0.1	0.3	-0.3	0.3
Extensor digitorum longus weight	0.6	2.5	2.8	1.5	1.6	-1.7
Bone: elastic displacement	1.7	1.9	2.0	-1.4	-1.4	1.4
Bone: elastic work	0.6	0.7	0.8	-0.7	-0.9	0.9
Bone: endosteal estimation	0.1	0.3	0.7	-0.8	-0.3	0.3
Bone: endosteal perimeter	0.2	0.5	1.0	-1.0	-0.5	0.5
Epididymis fat weight	2.0	6.9	7.0	-2.6	-2.6	2.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	-1.0	-0.3	0.3
Delta time in open arm before/after self-admin	1.0	1.0	3.0	1.7	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.8	1.0	1.9	1.4	0.7	-0.7
Delay discount exponential model param	0.0	0.0	0.0	0.2	-0.2	0.2
Extinction: sum of active levers before priming	0.7	0.7	0.9	0.7	0.9	-0.9
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.6	-0.1	0.1
Bone: final force	0.8	1.3	1.3	1.1	1.1	-1.1
Bone: final moment	0.3	0.5	0.6	0.7	0.7	-0.7
Food consumed during 24 hour testing period	0.7	0.9	2.3	-1.5	-0.4	0.5
Glucose	1.8	2.8	2.9	1.7	1.7	-1.6
Heart weight	0.0	0.1	0.1	0.4	0.1	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.1	-0.3	0.3
Intermittent access intake day 1-15 change	0.9	1.8	2.7	0.6	1.6	-1.6
Intermittent access intake escalation	1.0	2.1	3.0	0.7	1.7	-1.7
Intermittent access intake escalation 2	0.7	0.9	1.3	0.1	1.2	-1.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.4	0.3	-0.2
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.6	1.3	0.4	-0.4
Intermitt. access escalation Index	0.4	0.5	0.8	-0.9	-0.6	0.6
Intermittent access day 1 total infusions	0.2	0.3	0.9	-1.0	0.2	-0.2
Intermittent access day 15 total infusions	1.2	1.8	2.8	0.0	1.7	-1.6
Intermittent access terminal intake (last 3 days)	2.1	2.8	4.2	0.4	2.0	-2.0
Intermittent access total infusions	1.6	1.8	2.8	0.0	1.7	-1.6
Intermittent access day 1 locomotion	1.6	2.1	3.4	-1.8	-1.2	1.2
Intermittent access day 15 total locomotion	0.2	0.4	0.6	-0.8	-0.5	0.5
Intermittent access total locomotion	0.1	0.1	0.1	-0.4	-0.2	0.2
Intermittent access standard deviation	0.1	0.2	0.2	-0.4	-0.5	0.5
Left kidney weight	1.8	8.2	10.4	3.2	2.6	-2.7
Right kidney weight	1.8	8.1	10.3	3.2	2.6	-2.7
Cocaine induced anxiety	2.1	3.0	3.8	-1.2	-2.0	1.9
Post-drug Anxiety	0.4	0.4	0.6	-0.4	-0.7	0.7
Baseline Anxiety	1.3	1.5	2.3	0.5	1.5	-1.4
Tail length	0.1	0.4	1.2	-1.1	-0.0	0.1
Length with tail	0.2	0.7	1.0	-1.0	-0.8	0.8
Length without tail	0.5	1.5	1.6	-1.1	-1.3	1.3
Times rat made contact with spout	2.0	2.2	3.3	-1.8	-1.3	1.3
Lifetime Intake	1.3	1.5	2.4	-0.1	1.5	-1.5
Liver weight, left	0.2	0.3	0.4	-0.3	-0.7	0.6
Liver weight, right	0.6	1.0	1.4	-1.2	-0.9	0.9
Locomotor activity	2.4	3.7	4.6	-1.4	-2.2	2.1
Locomotor testing distance	2.1	3.7	4.1	-1.7	-2.0	2.0
Locomotor testing rearing	0.2	0.4	0.6	0.1	-0.7	0.7
Locomotion in novel chamber	2.0	2.6	2.9	-1.5	-1.7	1.7
Locomotion in novel chamber post-restriction	2.3	3.8	5.5	-2.3	-1.7	1.7
Fecal boli incidents, locomotor time 1	2.1	3.0	6.0	-2.5	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.8	0.8	1.0	1.0	0.8	-0.8
Time >=10cm from walls, locomotor time 1	1.3	1.4	3.3	-1.8	-0.6	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	-0.3	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.3	0.0	-0.0
Rest time, locomotor task time 1	0.1	0.1	0.1	0.1	0.4	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.2	-0.4	0.4
Vertical activity count, locomotor time 1	0.7	1.6	2.3	-1.5	-1.1	1.1
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.3	0.5	0.6	-0.6
Bouts of movement, locomotor time 2	0.6	0.9	0.9	0.9	0.9	-1.0
Total resting periods, locomotor time 2	0.7	1.2	1.2	1.1	1.1	-1.1
Rest time, locomotor task time 2	0.4	0.5	0.7	-0.1	0.8	-0.8
Distance moved, locomotor task time 2	0.5	0.6	0.8	0.4	-0.9	0.9
Vertical activity count, locomotor time 2	0.8	1.1	1.5	-0.6	-1.2	1.2
Light reinforcement 1	2.0	5.0	5.8	-1.8	-2.4	2.4
Light reinforcement 2	2.2	3.4	3.7	-1.7	-1.9	1.9
Bone: marrow area	0.1	0.2	0.6	-0.8	-0.2	0.3
Bone: maximum diameter	0.5	0.9	1.1	-1.1	-0.9	0.9
Bone: maximum force	0.3	0.5	0.8	0.9	0.6	-0.6
Bone: maximum moment	0.1	0.1	0.2	0.5	0.2	-0.2
Mean time between licks in bursts	0.0	0.0	0.0	-0.0	-0.0	0.1
Mean num. licks in bursts	0.1	0.1	0.3	-0.6	0.0	-0.0
Cd content in liver	0.2	0.2	0.6	0.8	0.3	-0.3
Co content in liver	0.0	0.0	0.0	0.0	0.2	-0.2
Cu content in liver	0.7	0.8	1.1	0.6	1.0	-1.0
Fe content in liver	2.2	2.7	2.8	-1.6	-1.7	1.6
K content in liver	0.1	0.1	0.2	-0.1	0.4	-0.4
Mg content in liver	0.6	0.6	1.1	-1.0	-0.6	0.6
Mn content in liver	0.5	0.6	0.6	-0.7	-0.8	0.8
Na content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1
Rb content in liver	0.2	0.2	0.3	0.1	0.5	-0.5
Se content in liver	0.0	0.0	0.1	0.2	0.2	-0.2
Sr content in liver	1.1	0.9	1.0	-1.0	-0.9	1.0
Zn content in liver	1.6	1.7	2.1	1.0	1.5	-1.4
Bone: minimum diameter	0.1	0.2	0.2	-0.5	-0.5	0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.4	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.4	0.4	-0.4
Total zone transitions, hab. session 1	0.9	1.3	1.6	-1.3	-1.1	1.1
Total locomotion distance, hab. session 1	1.2	1.7	1.8	-1.3	-1.3	1.3
Locomotion velocity, hab. session 1	1.6	2.2	2.6	-1.6	-1.4	1.4
Time in familiar zone, hab. session 2	0.6	0.6	0.8	-0.5	-0.9	0.9
Time in novel zone, hab. session 2	4.2	4.2	4.5	2.0	2.1	-2.1
Total zone transitions, hab. session 2	2.3	2.9	3.0	-1.7	-1.7	1.7
Total locomotion distance, hab. session 2	1.4	1.9	2.3	-1.5	-1.3	1.3
Locomotion velocity, hab. session 2	1.3	1.8	2.1	-1.5	-1.3	1.3
Novel to familiar place preference ratio	2.7	2.9	3.9	2.0	1.6	-1.6
Novelty place preference	4.1	4.4	5.7	2.4	1.9	-1.9
Time in novel zone, NPP test	3.8	4.0	5.2	2.3	1.8	-1.9
Total zone transitions, NPP test	1.9	2.8	3.0	-1.7	-1.6	1.6
Total locomotion distance, NPP test	1.2	1.6	1.8	-1.4	-1.2	1.2
Locomotion velocity, NPP test	1.0	1.4	1.6	-1.3	-1.2	1.1
Intraocular pressure	0.7	1.0	1.9	1.4	0.7	-0.8
Delta distance traveled before/after self-admin	0.4	0.4	0.6	0.4	0.8	-0.7
Delta ambulatory time before/after self-admin	0.5	0.7	1.0	0.1	1.0	-1.0
Parametrial fat weight	6.8	16.0	16.8	-3.8	-4.1	4.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.4	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.3	0.8	-0.8
Pavlov. Cond. change in total contacts	0.9	0.9	1.2	1.1	0.9	-0.9
Pavlov. Cond. index score	0.3	0.3	0.4	0.5	0.6	-0.6
Pavlov. Cond. latency score	0.2	0.2	0.3	0.4	0.5	-0.5
Pavlov. Cond. lever contacts	0.5	0.6	0.7	0.9	0.7	-0.7
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	-0.4	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.4	0.6	0.6	-0.6
Pavlov. Cond. response bias	0.2	0.2	0.3	0.3	0.5	-0.5
Pavlov. Cond. lever latency	1.2	1.6	1.7	-1.2	-1.3	1.3
Pavlov. Cond. magazine entry latency	3.4	4.1	4.2	2.0	2.0	-2.0
Pavlov. Cond. change in total contacts	1.8	2.9	3.3	1.8	1.6	-1.6
Pavlov. Cond. index score	3.2	4.3	4.5	2.0	2.1	-2.1
Pavlov. Cond. latency score	3.3	4.4	4.5	2.1	2.1	-2.1
Pavlov. Cond. lever contacts	1.4	1.9	2.1	1.2	1.5	-1.5
Pavlov. Cond. magazine entry number	5.6	6.9	7.4	-2.7	-2.6	2.6
Pavlov. Cond. intertrial magazine entries	4.9	7.3	7.7	-2.8	-2.7	2.7
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.9	5.1	2.1	2.2	-2.3
Pavlov. Cond. response bias	2.9	3.9	4.0	1.9	2.0	-2.0
Time in closed arm before self-admin	2.9	3.7	3.9	-1.8	-2.0	2.0
Time in closed arm after self-admin	2.7	2.9	3.5	-1.4	-1.9	1.9
Time in open arm before self-admin	1.3	1.4	1.7	0.9	1.3	-1.3
Time in open arm after self-admin	1.0	1.1	2.0	1.4	0.8	-0.8
Bone: periosteal estimation	0.3	0.5	0.6	-0.8	-0.7	0.7
Bone: periosteal perimeter	0.7	1.3	1.3	-1.1	-1.1	1.1
Bone: post-yield work	0.4	0.6	0.7	-0.6	-0.8	0.9
Progressive ratio test 1 active lever presses	2.0	2.5	3.8	0.4	1.9	-1.9
Progressive ratio test 1 breakpoint	1.8	2.2	3.3	0.4	1.8	-1.8
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.5	0.3	-0.3
Progressive ratio test 2 active lever presses	1.5	1.8	2.7	-0.5	1.6	-1.6
Progressive ratio test 2 breakpoint	1.6	1.8	2.8	-0.4	1.7	-1.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.1	0.4	-0.4
Incentive Sensitization - Responses	0.6	0.8	0.8	-0.9	0.9	-0.9
Incentive Sensitization - Breakpoint	0.7	0.9	1.0	-0.9	1.0	-1.0
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.4	1.2	0.5	-0.6
Progressive ratio	0.7	1.1	3.4	1.8	-0.1	0.0
Food seeking constrained by brief footshock	1.7	2.1	2.8	1.7	1.3	-1.4
Seeking ratio, punishment vs. effort	0.4	0.6	1.0	-0.2	1.0	-0.9
Retroperitoneal fat weight	6.2	26.4	28.3	-4.8	-5.3	5.3
Reaction time number correct	0.8	1.6	2.0	0.8	1.4	-1.4
Reaction time mean minus median	1.0	2.5	4.9	2.2	1.1	-1.2
Reaction time mean minus median AUC	0.8	2.1	4.4	2.1	0.9	-1.0
Reaction time num false alarms	0.1	0.2	0.2	0.4	0.4	-0.4
Reaction time num false alarms AUC	0.0	0.1	0.2	-0.4	-0.0	0.0
Reaction time trials correct on left	0.8	1.6	2.0	0.8	1.4	-1.4
Reaction time trials on left	0.9	1.6	2.1	0.8	1.5	-1.4
Reaction time mean	1.1	1.7	5.2	2.3	0.1	-0.2
Reaction time mean AUC	1.3	2.1	6.0	2.5	0.4	-0.5
Median of all reaction times	0.8	1.2	3.5	1.9	-0.2	0.1
Reaction time omissions	0.3	0.4	1.2	-1.1	-0.3	0.3
Reaction time false alarm rate	0.4	0.5	0.5	-0.7	-0.7	0.7
Reaction time premature initiation rate	1.4	2.0	2.6	1.6	1.3	-1.3
Reaction time premature initiations	2.3	4.0	4.1	2.0	2.0	-2.0
Std. dev. reaction times	0.8	1.5	3.9	2.0	0.4	-0.5
Reaction time trials completed	0.9	1.6	2.1	0.8	1.5	-1.4
Reaction time trials AUC	0.9	1.7	2.2	0.8	1.5	-1.5
Run reversals in cocaine runway, females	2.2	2.2	3.2	-1.8	-1.3	1.3
Run reversals in cocaine runway, males	1.4	1.4	3.1	-1.8	-0.7	0.7
Latency to leave start box in cocaine runway	0.5	0.6	1.1	1.1	0.5	-0.5
Latency to leave start box in cocaine runway, F	1.0	1.2	1.5	0.8	1.2	-1.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.0	0.8	-1.0	0.9
Std. dev. time between licks in bursts	1.8	2.5	2.7	-1.5	-1.6	1.6
Total sessions with >9 infusions	1.0	1.2	1.8	-0.2	1.3	-1.3
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	0.1
Short access day 10 total inactive lever presses	0.1	0.3	0.3	-0.5	-0.5	0.5
Short access day 1 total infusions	0.5	0.7	1.4	-1.2	0.6	-0.6
Short access day 10 total infusions	0.4	0.5	0.7	-0.9	0.6	-0.6
Short access total infusions	1.2	1.5	2.3	-0.3	1.5	-1.5
Short access day 1 locomotion	0.3	0.3	0.7	-0.8	0.4	-0.4
Short access day 10 total locomotion	1.2	2.3	2.6	-1.3	-1.6	1.6
Short access total locomotion	0.3	0.3	0.4	-0.6	-0.6	0.6
One hour access (0.3 mA shock)	0.8	0.9	1.3	-0.5	1.1	-1.1
Compulsive drug intake	0.1	0.1	0.2	-0.1	-0.4	0.4
One hour access (shock baseline)	0.7	1.1	1.5	-0.5	1.2	-1.2
Social response proportion	0.5	0.5	0.8	-0.3	0.9	-0.8
Social responses	0.1	0.1	0.4	-0.6	0.1	-0.1
Social time	0.1	0.2	0.4	-0.6	0.2	-0.2
Soleus weight	0.2	0.5	0.6	-0.4	-0.8	0.8
Bone: stiffness	3.2	5.2	5.5	2.4	2.2	-2.3
Tibialis anterior weight	0.2	0.5	0.6	0.6	0.8	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.5	-0.3	0.7	-0.7
Time to tail flick, vehicle, after self-admin	1.6	2.2	4.4	-2.1	-1.0	1.0
Time to tail flick, test, before self-admin	4.4	4.5	6.8	-2.6	-1.8	1.8
Time to tail flick, test, after self-admin	0.5	0.6	1.6	-1.3	-0.2	0.3
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	3.0	-1.7	-1.0	1.0
Delta time to tail flick, test, before/after SA	0.9	1.0	1.2	0.7	1.1	-1.1
Tibia length	0.0	0.0	0.1	0.2	0.1	-0.1
Ambulatory time before self-admin	0.8	1.1	1.6	0.6	-1.3	1.2
Ambulatory time after self-admin	0.2	0.2	0.4	0.1	-0.6	0.6
Bone: tissue strength	0.3	0.3	0.3	0.5	0.5	-0.5
Total heroin consumption	1.1	1.3	1.4	1.2	1.1	-1.2
Bone: trabecular number	0.2	0.4	0.6	-0.1	-0.8	0.7
Bone: trabecular spacing	0.2	0.2	0.6	-0.8	-0.2	0.2
Bone: trabecular thickness	0.6	0.8	1.4	1.2	0.7	-0.7
Bone: trabecular tissue density	0.7	1.1	1.2	1.1	1.0	-1.0
Water consumed over 24 hours	0.4	0.6	1.1	-1.0	-0.6	0.6
Number of responses in last shaping day	1.7	1.9	4.2	2.0	0.8	-0.9