Hub : Genes

Lratd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Lratd1 0.09 0.05 1.5e-03 0.05 0.09 0.04 0.07 3.8e-03 2.0e-04 7.2e-03 7.0e-04
2 OFC gene expression Lratd1 0.28 0.14 3.1e-03 0.05 0.04 0.02 0.07 3.1e-02 5.0e-02 1.2e-01 1.2e-02
3 IL gene expression Lratd1 0.19 0.1 4.8e-03 0.09 0.07 0.04 0.07 2.9e-03 8.5e-03 4.7e-02 9.2e-03
4 NAcc gene expression Lratd1 0.16 0.06 0.0e+00 0.05 0.13 0.12 0.12 3.5e-08 4.5e-19 9.8e-18 3.5e-17
5 Brain gene expression Lratd1 0.21 0.09 9.1e-15 0.17 0.16 0.17 0.17 8.9e-16 2.3e-14 2.2e-15 1.5e-15
6 NAcc mRNA stability Lratd1 0.02 0.01 3.2e-03 0.02 0.01 0.02 0.02 1.8e-04 2.1e-03 9.7e-04 8.3e-04
7 BLA mRNA stability Lratd1 0.07 0.04 1.3e-03 0.04 0.04 0.02 0.03 5.6e-03 4.8e-03 2.4e-02 1.7e-02
8 Eye gene expression Lratd1 0.33 0.16 6.0e-03 0.1 0.09 0.1 0.09 1.3e-02 2.1e-02 1.3e-02 1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.02.30.91.21.20.31.5-0.9-0.70.7
Area under the delay curve0.10.10.30.30.40.50.50.00.4-0.10.1
BMI with tail0.61.93.9-1.9-1.8-2.0-0.9-0.41.21.40.2
BMI without tail0.31.02.3-1.5-1.0-1.4-1.1-0.10.81.10.2
Body weight0.52.46.2-2.2-2.1-2.5-1.5-0.40.61.2-0.1
Weight adjusted by age0.91.43.3-0.9-1.3-1.3-1.1-1.5-0.6-0.3-1.8
Bone surface0.20.41.90.30.50.70.01.4-0.3-0.30.8
Bone volume0.71.32.61.21.51.60.41.3-1.0-1.00.5
Breakpoint value in progressive ratio session0.30.41.50.1-0.3-0.50.4-1.20.10.1-1.0
Number of licking bursts0.00.00.10.10.20.4-0.2-0.1-0.1-0.20.1
Context. condit. distance diff. score0.30.40.9-0.9-0.8-0.9-0.6-0.10.60.50.1
Locomotion velocity, session 10.70.82.9-1.4-0.8-0.3-1.70.40.70.30.5
Locomotion distance, session 11.51.94.0-0.4-0.60.1-1.9-1.9-1.1-1.6-2.0
Locomotion velocity, session 20.10.10.60.10.20.2-0.3-0.1-0.8-0.5-0.1
Locomotion distance, session 20.71.02.5-0.5-0.4-0.1-1.5-1.6-0.2-0.8-1.5
Locomotion velocity, session 30.10.20.7-0.10.20.5-0.9-0.3-0.2-0.4-0.2
Locomotion distance, session 30.50.61.1-1.0-0.4-0.4-1.00.41.00.80.6
Stereotopy head waving bouts, day 31.31.54.01.51.31.52.01.0-0.00.11.1
Stereotopy head waving duration, day 30.20.30.70.70.30.60.80.2-0.5-0.50.2
Locomotion velocity, session 71.31.44.5-1.6-1.0-0.9-2.1-0.71.10.3-0.5
Locomotion distance, session 70.91.22.3-1.5-0.9-1.4-1.00.41.21.20.5
Stereotopy head waving bouts, day 70.91.12.91.31.01.70.3-0.3-0.7-1.4-0.4
Stereotopy head waving duration, day 70.81.02.11.20.71.30.4-0.3-1.3-1.4-0.5
Locomotion velocity, session 81.41.64.0-1.5-1.1-1.3-0.30.22.01.80.6
Locomotion distance, session 81.52.27.8-1.4-0.9-0.6-2.8-1.7-0.1-0.9-1.5
Degree of sensitization distance0.20.20.8-0.1-0.3-0.90.60.10.10.6-0.0
Degree of sensitization stereotypy0.60.61.60.70.51.0-0.3-0.6-0.8-1.3-0.7
Conditioned locomotion1.51.74.71.42.22.20.20.8-0.5-1.00.6
Cocaine response after cond. corrected1.31.54.31.61.82.11.30.40.2-0.10.4
Cocaine response after cond. not corrected1.92.34.92.12.22.21.70.9-0.4-0.40.4
Cocaine response before conditioning1.11.34.31.30.90.60.50.7-2.1-1.5-0.3
Saline control response1.41.94.7-0.1-0.70.3-1.8-1.1-1.7-2.2-1.6
Bone: connectivity density0.40.62.80.30.60.80.21.7-0.1-0.01.0
Bone: cortical apparent density0.60.82.0-0.80.1-0.1-0.91.40.70.71.4
Bone: cortical area0.20.30.90.30.70.5-0.40.2-0.9-0.60.3
Bone: cortical porosity3.53.77.32.52.72.71.91.5-1.0-0.91.2
Bone: cortical porosity3.03.35.92.32.42.42.01.4-0.9-0.81.3
Bone: cortical thickness0.61.04.0-0.9-0.5-0.4-2.0-0.9-0.9-0.7-0.6
Bone: cortical thickness1.11.32.80.30.71.1-1.7-0.7-1.4-1.6-0.9
Bone: cortical tissue density0.71.02.3-0.90.1-0.2-0.91.50.90.91.5
Condit. Reinf. active minus inactive responses0.60.71.6-1.1-1.3-1.2-0.8-0.30.60.4-0.1
Condit. Reinf. active-inactive response ratio1.11.22.4-1.6-1.5-1.5-1.00.21.00.80.3
Condit. Reinf. active responses0.20.30.6-0.5-0.8-0.7-0.6-0.6-0.2-0.2-0.5
Condit. Reinf. inactive responses0.10.10.30.40.40.40.2-0.1-0.5-0.3-0.2
Incentive salience index mean0.20.20.8-0.7-0.3-0.3-0.90.30.20.10.5
Condit. Reinf. lever presses0.91.23.30.91.81.7-0.11.1-0.5-0.70.8
Condit. Reinf. active minus inactive responses0.70.92.40.2-1.1-0.70.6-1.3-0.7-0.7-1.6
Condit. Reinf. active-inactive response ratio0.50.52.01.0-0.00.11.4-0.5-0.5-0.4-0.8
Condit. Reinf. active responses2.43.38.9-1.8-3.0-2.5-1.4-1.80.1-0.1-1.7
Condit. Reinf. inactive responses3.34.38.8-2.8-2.9-2.6-3.0-1.20.40.2-0.9
Condit. Reinf. lever presses0.50.72.0-0.7-1.4-1.1-0.5-0.9-0.4-0.2-0.9
Condit. Reinf. lever reinforcers received2.33.29.2-1.8-3.0-2.5-1.2-1.70.20.1-1.5
Conditioned reinforcement - actives0.00.10.2-0.3-0.2-0.2-0.5-0.20.10.00.2
Conditioned reinforcement - inactives0.10.10.40.40.50.60.1-0.1-0.3-0.20.2
Conditioned locomotion0.40.50.90.81.00.70.70.9-0.5-0.20.7
Patch foraging indifference point 0 sec0.61.02.4-0.4-1.0-0.7-1.0-1.4-0.7-0.9-1.5
Patch foraging indifference point AUC0.40.51.40.2-1.1-0.61.2-0.9-0.10.2-0.6
Delay disc. indifference point, 0s delay0.30.30.8-0.20.90.9-0.70.50.4-0.00.2
Delay disc. indifference point, 16s delay0.10.10.2-0.2-0.20.1-0.4-0.50.4-0.2-0.3
Delay disc. indifference point, 2s delay0.20.20.40.50.10.40.30.0-0.6-0.7-0.6
Delay disc. indifference point, 24s delay0.10.10.5-0.10.40.0-0.1-0.20.70.10.2
Delay disc. indifference point, 4s delay2.82.95.72.41.62.01.7-0.5-1.8-2.0-0.9
Delay disc. indifference point, 8s delay0.50.62.0-0.5-0.2-0.20.30.71.41.10.9
Indifference point function ln k0.20.41.10.61.00.6-0.20.1-0.7-0.8-0.2
Indifference point function log k0.20.41.10.61.00.6-0.20.1-0.7-0.8-0.2
Patch foraging total patch changes 0 sec0.61.12.8-0.2-0.8-0.5-1.0-1.4-1.0-1.2-1.7
Patch foraging total patch changes 12 sec1.11.42.41.2-0.60.21.4-1.5-1.3-1.1-1.6
Patch foraging total patch changes 18 sec1.72.66.30.6-1.3-0.70.4-2.5-1.7-1.6-2.5
Patch foraging total patch changes 24 sec0.30.51.10.8-0.30.01.0-0.7-0.9-0.6-0.7
Patch foraging total patch changes 6 sec0.71.12.9-0.3-1.6-1.10.2-1.5-0.2-0.3-1.7
Patch foraging time to switch 0 sec0.30.61.50.10.80.9-0.01.20.60.31.1
Patch foraging water rate 0 sec0.10.30.80.2-0.3-0.60.9-0.70.10.3-0.7
Patch foraging water rate 12 sec0.10.21.00.4-0.0-0.31.0-0.7-0.20.1-0.5
Patch foraging water rate 18 sec0.71.15.21.20.0-0.42.3-1.0-0.30.2-1.1
Patch foraging water rate 24 sec0.40.61.7-0.3-0.8-1.30.8-0.90.50.7-0.5
Patch foraging water rate 6 sec0.40.61.80.4-0.1-0.80.7-1.3-0.4-0.1-1.3
Seeking ratio, delayed vs. immediate footshock0.40.51.70.5-0.5-0.50.9-0.6-1.3-0.5-0.5
Distance traveled before self-admin0.10.20.30.40.50.6-0.0-0.5-0.3-0.4-0.3
Distance traveled after self-admin1.01.22.61.60.91.11.4-0.6-0.6-0.8-1.2
Extensor digitorum longus weight0.41.56.6-1.6-1.1-1.1-2.6-0.1-0.5-0.60.0
Bone: elastic displacement0.20.20.9-0.2-0.1-0.1-0.6-1.00.2-0.2-0.6
Bone: elastic work0.40.52.5-0.7-0.40.2-1.6-0.60.0-0.5-0.3
Bone: endosteal estimation0.30.61.10.91.00.91.00.9-0.10.00.7
Bone: endosteal perimeter0.71.53.41.61.71.91.30.8-0.7-0.70.5
Epididymis fat weight0.61.95.2-1.6-0.8-1.9-0.60.21.62.30.7
Delta time in closed arm before/after self-admin1.11.13.60.4-0.6-0.2-0.0-1.6-0.8-1.0-1.9
Delta time in open arm before/after self-admin0.30.30.6-0.6-0.3-0.3-0.20.70.60.70.7
Diff in mean of infusions in LGA sessions0.50.72.21.20.70.91.50.3-0.3-0.20.1
Delay discount exponential model param0.10.20.4-0.5-0.3-0.5-0.60.3-0.10.30.2
Extinction: sum of active levers before priming2.12.34.92.21.31.51.6-1.1-1.4-1.5-1.3
Active lever presses in extinction session 61.61.64.10.4-1.1-1.01.5-2.0-0.20.3-1.9
Bone: final force0.20.30.90.00.50.3-0.21.0-0.1-0.00.9
Bone: final moment0.20.31.10.00.40.4-0.11.1-0.00.11.0
Food consumed during 24 hour testing period0.60.84.41.1-0.10.12.1-0.2-0.7-0.1-0.4
Glucose1.72.74.8-2.0-0.9-1.0-1.21.42.12.21.8
Heart weight0.50.81.71.11.00.41.30.7-1.0-0.00.5
Delay discount hyperbolic model param0.20.20.5-0.6-0.6-0.7-0.60.1-0.00.40.2
Intermittent access intake day 1-15 change0.20.40.90.90.70.70.3-0.1-1.0-0.9-0.2
Intermittent access intake escalation0.40.71.61.10.80.60.5-0.4-1.3-1.2-0.5
Intermittent access intake escalation 20.10.10.40.10.50.0-0.10.50.10.20.6
Intermitt. access day 1 inactive lever presses0.10.61.50.81.20.7-0.1-0.6-0.8-0.8-0.4
Intermitt. access day 15 inactive lever presses0.30.61.10.71.01.00.40.9-0.7-0.30.9
Intermitt. access escalation Index0.10.10.50.0-0.30.4-0.3-0.2-0.2-0.7-0.2
Intermittent access day 1 total infusions0.50.81.70.61.31.30.41.10.20.01.1
Intermittent access day 15 total infusions0.60.92.61.01.61.40.20.6-0.7-0.80.5
Intermittent access terminal intake (last 3 days)0.20.20.90.21.00.7-0.50.2-0.1-0.30.2
Intermittent access total infusions0.60.71.90.31.41.1-0.11.10.20.11.1
Intermittent access day 1 locomotion1.31.74.51.42.12.00.30.9-0.9-0.90.7
Intermittent access day 15 total locomotion1.01.84.51.42.11.80.51.3-1.1-0.91.0
Intermittent access total locomotion1.41.74.21.52.11.70.71.0-1.1-0.90.7
Intermittent access standard deviation0.20.40.8-0.9-0.5-0.3-0.60.60.60.70.8
Left kidney weight0.20.92.7-1.2-0.7-1.4-1.6-0.4-0.50.2-0.4
Right kidney weight0.41.83.0-0.8-1.3-1.6-1.3-1.7-1.3-0.5-1.6
Cocaine induced anxiety1.21.72.8-1.4-0.3-0.3-1.01.71.61.41.6
Post-drug Anxiety0.70.82.2-0.20.80.7-0.41.50.70.61.4
Baseline Anxiety0.91.02.31.20.60.70.5-0.9-1.5-1.3-0.9
Tail length0.10.41.2-0.6-0.3-0.3-1.1-0.8-0.3-0.2-0.9
Length with tail0.41.73.3-0.7-1.2-1.3-1.2-1.7-1.1-0.8-1.8
Length without tail0.61.84.2-0.0-1.1-1.3-0.4-1.8-1.5-1.2-2.1
Times rat made contact with spout4.95.611.33.23.43.03.31.4-0.6-0.60.9
Lifetime Intake0.40.51.40.31.21.0-0.40.8-0.2-0.20.9
Liver weight, left1.83.06.5-2.5-2.1-2.1-2.3-0.81.11.0-0.2
Liver weight, right0.00.10.2-0.10.3-0.3-0.5-0.2-0.4-0.10.1
Locomotor activity0.20.30.90.40.61.00.10.60.1-0.10.7
Locomotor testing distance0.61.23.01.31.61.70.10.4-0.8-1.10.1
Locomotor testing rearing0.61.32.41.60.91.30.9-0.5-1.3-1.4-0.7
Locomotion in novel chamber0.10.10.2-0.00.30.5-0.20.4-0.3-0.10.4
Locomotion in novel chamber post-restriction0.40.71.50.80.20.40.2-1.2-1.2-0.7-1.0
Fecal boli incidents, locomotor time 10.10.20.4-0.1-0.7-0.30.6-0.20.40.6-0.1
Change in fecal boli incidents, locomotor task0.70.61.50.11.21.0-0.51.20.50.10.7
Time >=10cm from walls, locomotor time 10.30.31.5-0.30.50.3-0.10.31.20.90.0
Bouts of movement, locomotor time 11.21.44.6-0.6-1.0-0.6-1.2-2.1-0.3-0.7-1.6
Total resting periods, locomotor time 11.01.13.4-0.6-1.0-0.6-1.1-1.8-0.4-0.7-1.4
Rest time, locomotor task time 10.10.10.30.00.40.3-0.10.5-0.10.10.5
Distance moved, locomotor task time 10.10.20.5-0.50.1-0.1-0.50.20.70.40.4
Vertical activity count, locomotor time 10.30.82.30.0-0.3-0.3-0.7-1.5-0.7-1.1-1.3
Time >=10cm from walls, locomotor time 20.10.10.70.30.80.1-0.10.10.0-0.1-0.3
Bouts of movement, locomotor time 20.40.62.20.91.00.21.50.30.40.5-0.1
Total resting periods, locomotor time 20.40.62.11.11.10.41.50.40.40.40.0
Rest time, locomotor task time 20.10.20.7-0.3-0.00.1-0.20.20.80.70.2
Distance moved, locomotor task time 20.30.31.2-0.6-0.4-0.4-1.1-0.7-0.3-0.3-0.2
Vertical activity count, locomotor time 20.30.41.00.10.1-0.1-0.8-0.8-1.0-0.9-0.6
Light reinforcement 11.53.68.21.2-0.80.30.3-2.9-1.6-2.7-2.9
Light reinforcement 21.72.65.11.90.51.41.1-1.5-1.9-2.3-1.6
Bone: marrow area0.30.71.10.91.00.91.10.9-0.10.00.8
Bone: maximum diameter0.81.43.01.41.31.30.5-0.5-1.7-1.4-0.7
Bone: maximum force0.10.20.6-0.2-0.3-0.1-0.7-0.1-0.8-0.6-0.2
Bone: maximum moment0.10.10.3-0.2-0.3-0.1-0.40.0-0.5-0.4-0.0
Mean time between licks in bursts0.61.53.6-0.5-1.6-1.2-0.5-1.7-0.8-0.5-1.9
Mean num. licks in bursts1.32.06.01.91.71.52.40.9-0.1-0.10.4
Cd content in liver0.20.21.00.1-0.2-0.71.0-0.10.20.50.2
Co content in liver0.20.20.90.40.10.41.0-0.30.60.2-0.1
Cu content in liver0.40.41.7-0.8-0.3-0.5-1.3-0.80.2-0.1-0.4
Fe content in liver0.60.81.80.1-0.9-0.4-0.3-1.3-0.9-1.0-1.3
K content in liver0.50.51.40.20.91.0-1.20.0-0.2-0.90.2
Mg content in liver0.91.02.70.51.51.6-1.00.4-0.5-1.00.3
Mn content in liver0.10.10.20.20.30.40.20.30.0-0.10.3
Na content in liver3.33.67.51.42.42.6-1.50.1-2.2-2.7-0.5
Rb content in liver0.10.20.4-0.1-0.6-0.3-0.3-0.5-0.4-0.2-0.6
Se content in liver0.60.71.40.50.50.7-0.7-0.8-0.8-1.2-1.2
Sr content in liver0.10.10.40.10.10.30.1-0.40.5-0.2-0.6
Zn content in liver0.10.10.30.10.20.1-0.3-0.5-0.3-0.5-0.6
Bone: minimum diameter0.40.62.50.60.40.01.60.80.10.61.0
Time in familiar zone, hab. session 10.30.31.0-0.3-0.6-1.00.50.20.00.70.2
Time in novel zone, hab. session 10.00.00.2-0.1-0.10.1-0.1-0.40.3-0.0-0.2
Total zone transitions, hab. session 13.85.410.91.80.61.4-0.4-2.7-3.0-3.2-3.3
Total locomotion distance, hab. session 13.34.69.01.70.81.4-0.3-2.6-2.7-3.0-2.9
Locomotion velocity, hab. session 13.24.69.51.81.01.6-0.4-2.2-2.8-3.1-2.6
Time in familiar zone, hab. session 20.70.73.00.3-0.4-0.61.70.80.10.80.8
Time in novel zone, hab. session 20.40.42.0-0.60.10.1-1.4-0.70.5-0.0-0.5
Total zone transitions, hab. session 21.01.22.60.20.40.7-1.5-1.0-1.4-1.6-1.2
Total locomotion distance, hab. session 21.11.53.70.60.20.4-0.5-1.8-1.4-1.5-1.9
Locomotion velocity, hab. session 21.01.43.30.60.30.5-0.6-1.7-1.3-1.4-1.8
Novel to familiar place preference ratio1.41.53.4-0.4-0.5-0.0-1.9-1.8-0.8-1.4-1.6
Novelty place preference1.71.84.5-0.3-0.6-0.1-1.8-2.1-0.9-1.5-1.8
Time in novel zone, NPP test1.51.63.6-0.2-0.30.2-1.6-1.9-1.0-1.5-1.7
Total zone transitions, NPP test1.31.83.5-0.0-0.10.5-1.7-1.5-1.4-1.8-1.9
Total locomotion distance, NPP test1.11.42.80.70.71.2-0.9-1.5-1.0-1.7-1.5
Locomotion velocity, NPP test1.11.53.30.50.51.0-1.1-1.5-1.2-1.8-1.5
Intraocular pressure1.31.94.1-1.2-1.6-2.00.80.11.71.90.4
Delta distance traveled before/after self-admin1.81.95.12.11.41.42.30.5-0.9-0.6-0.2
Delta ambulatory time before/after self-admin1.21.53.71.90.81.11.9-0.2-1.0-0.9-0.8
Parametrial fat weight0.71.74.0-1.10.2-1.1-0.31.51.42.01.6
Pavlov. Cond. lever latency2.02.55.9-1.9-2.4-2.3-0.6-0.81.51.5-0.5
Pavlov. Cond. magazine entry latency0.91.22.71.41.61.21.00.7-0.9-0.70.5
Pavlov. Cond. change in total contacts2.02.24.82.21.21.41.9-0.4-1.7-1.4-0.5
Pavlov. Cond. index score2.02.65.52.12.32.11.20.8-1.5-1.30.5
Pavlov. Cond. latency score2.02.55.62.02.42.21.20.9-1.2-1.10.7
Pavlov. Cond. lever contacts2.53.07.22.22.72.51.00.9-1.4-1.40.5
Pavlov. Cond. magazine entry number0.91.12.2-1.3-1.5-1.2-1.2-1.00.60.4-0.9
Pavlov. Cond. intertrial magazine entries0.40.52.2-0.9-0.7-0.2-1.5-0.2-0.1-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.2.02.55.02.02.22.01.20.8-1.6-1.30.5
Pavlov. Cond. response bias2.22.76.02.12.52.21.21.0-1.4-1.10.7
Pavlov. Cond. lever latency0.20.20.4-0.30.2-0.0-0.30.60.70.50.6
Pavlov. Cond. magazine entry latency1.41.64.11.3-0.50.01.2-1.2-2.0-1.4-1.5
Pavlov. Cond. change in total contacts0.81.32.20.2-1.4-1.00.5-1.3-1.5-1.0-1.5
Pavlov. Cond. index score1.01.33.51.3-0.20.21.1-1.0-1.9-1.4-1.2
Pavlov. Cond. latency score1.31.74.11.4-0.10.41.1-1.2-2.0-1.6-1.4
Pavlov. Cond. lever contacts0.20.20.60.60.10.40.4-0.3-0.8-0.6-0.4
Pavlov. Cond. magazine entry number1.11.43.7-1.40.1-0.2-1.30.91.91.31.2
Pavlov. Cond. intertrial magazine entries1.32.04.3-2.1-0.9-1.4-1.90.31.81.30.6
Pavlov. Cond. lever-magazine prob. diff.1.21.63.91.50.10.41.3-0.9-2.0-1.4-1.2
Pavlov. Cond. response bias0.20.30.80.5-0.2-0.10.6-0.3-0.9-0.5-0.5
Time in closed arm before self-admin1.11.44.4-0.50.1-0.30.41.61.21.42.1
Time in closed arm after self-admin0.20.20.60.1-0.2-0.10.8-0.30.70.60.2
Time in open arm before self-admin1.61.73.50.81.51.6-1.10.7-1.9-1.80.1
Time in open arm after self-admin0.40.41.1-0.3-0.30.0-1.00.1-1.0-1.0-0.5
Bone: periosteal estimation0.30.61.20.81.11.00.40.6-0.9-0.60.6
Bone: periosteal perimeter0.30.51.50.70.81.20.1-0.3-0.6-0.7-0.2
Bone: post-yield work0.00.10.3-0.0-0.1-0.0-0.00.1-0.6-0.3-0.1
Progressive ratio test 1 active lever presses0.60.71.3-0.0-0.10.3-1.2-1.1-1.1-1.1-1.0
Progressive ratio test 1 breakpoint0.50.61.10.0-0.00.3-1.1-0.9-1.0-1.0-0.8
Progressive ratio test 1 inactive lever presses0.20.30.70.40.30.8-0.1-0.9-0.5-0.4-0.5
Progressive ratio test 2 active lever presses0.30.31.2-0.4-0.00.1-1.1-0.80.4-0.2-0.5
Progressive ratio test 2 breakpoint0.30.31.2-0.5-0.10.0-1.1-0.70.5-0.0-0.5
Progressive ratio test 2 inactive lever presses0.50.92.8-1.4-0.4-0.4-1.70.60.90.70.7
Incentive Sensitization - Responses0.60.91.9-1.2-0.2-0.5-1.20.61.40.90.7
Incentive Sensitization - Breakpoint0.60.82.0-1.2-0.3-0.5-1.10.61.41.00.6
Sum of active levers in priming session hrs 5-60.70.61.71.11.31.20.60.20.0-0.3-0.3
Progressive ratio0.71.12.71.41.51.61.30.2-0.5-0.30.5
Food seeking constrained by brief footshock1.62.06.21.91.51.32.51.1-0.2-0.11.0
Seeking ratio, punishment vs. effort0.30.41.2-0.5-1.1-1.10.10.00.40.3-0.4
Retroperitoneal fat weight3.515.028.2-5.3-4.2-5.0-3.0-0.24.44.40.9
Reaction time number correct0.61.22.2-1.1-1.5-1.3-1.4-1.4-0.3-0.4-1.0
Reaction time mean minus median0.41.03.4-0.80.1-0.4-0.71.80.10.71.6
Reaction time mean minus median AUC0.10.20.6-0.1-0.1-0.30.10.8-0.7-0.10.6
Reaction time num false alarms0.00.00.10.20.20.20.30.3-0.1-0.00.3
Reaction time num false alarms AUC0.10.10.20.30.20.50.0-0.1-0.5-0.4-0.2
Reaction time trials correct on left0.61.22.2-1.1-1.5-1.3-1.4-1.4-0.3-0.4-1.0
Reaction time trials on left0.61.22.1-1.2-1.4-1.3-1.4-1.2-0.2-0.4-0.9
Reaction time mean0.60.92.00.10.4-0.21.11.40.81.21.4
Reaction time mean AUC0.40.61.40.10.3-0.21.01.20.60.91.1
Median of all reaction times0.70.92.20.30.4-0.11.51.11.01.21.2
Reaction time omissions1.11.65.1-0.50.60.10.12.00.91.32.3
Reaction time false alarm rate0.30.40.80.70.80.90.70.6-0.1-0.00.4
Reaction time premature initiation rate0.20.20.6-0.10.80.2-0.60.60.00.10.8
Reaction time premature initiations0.20.31.7-0.8-0.1-0.6-1.3-0.2-0.1-0.10.2
Std. dev. reaction times0.40.72.7-0.20.3-0.10.31.60.20.81.5
Reaction time trials completed0.61.22.1-1.2-1.4-1.3-1.4-1.2-0.2-0.4-0.9
Reaction time trials AUC0.71.32.4-1.2-1.6-1.4-1.3-1.2-0.2-0.3-0.9
Run reversals in cocaine runway, females0.80.82.2-0.7-1.5-1.3-0.4-1.10.2-0.1-0.9
Run reversals in cocaine runway, males1.21.22.21.31.01.10.3-0.1-1.5-1.4-1.1
Latency to leave start box in cocaine runway0.10.10.4-0.20.20.3-0.50.40.70.0-0.1
Latency to leave start box in cocaine runway, F0.10.10.6-0.20.10.0-0.20.40.70.50.0
Latency to leave start box in cocaine runway, M0.10.10.40.30.20.4-0.20.0-0.0-0.7-0.3
Std. dev. time between licks in bursts0.91.22.8-1.2-1.7-1.3-0.7-1.30.80.5-0.7
Total sessions with >9 infusions1.01.32.41.11.61.50.41.3-0.9-0.51.2
Short access day 1 total inactive lever presses0.60.81.60.20.71.0-1.20.3-1.2-1.30.1
Short access day 10 total inactive lever presses0.10.30.9-0.1-0.3-0.4-0.5-0.8-0.7-0.4-1.0
Short access day 1 total infusions0.50.71.40.61.11.2-0.01.1-0.5-0.40.9
Short access day 10 total infusions0.60.81.80.31.21.00.31.10.60.51.3
Short access total infusions0.60.71.40.41.21.1-0.41.1-0.5-0.41.1
Short access day 1 locomotion2.73.36.12.52.12.31.80.9-2.0-1.60.5
Short access day 10 total locomotion1.32.44.91.82.21.71.21.5-1.5-0.91.2
Short access total locomotion2.53.05.82.12.42.11.21.4-1.8-1.31.0
One hour access (0.3 mA shock)0.20.30.6-0.6-0.4-0.3-0.8-0.60.50.1-0.5
Compulsive drug intake1.72.06.1-0.4-1.0-0.5-1.2-2.3-0.6-1.2-2.5
One hour access (shock baseline)0.40.61.30.41.10.70.31.10.00.31.1
Social response proportion0.40.40.80.1-0.8-0.90.9-0.8-0.30.0-0.6
Social responses0.60.81.80.0-1.0-0.80.0-1.4-0.7-0.9-1.2
Social time0.30.51.5-0.4-1.2-1.1-0.1-0.5-0.6-0.2-0.3
Soleus weight0.51.52.71.21.61.4-0.3-0.2-1.7-1.6-0.4
Bone: stiffness0.20.31.2-0.1-0.4-0.5-0.3-0.1-1.1-0.6-0.2
Tibialis anterior weight0.41.57.2-1.7-0.8-0.9-2.7-0.10.0-0.30.2
Time to tail flick, vehicle, before self-admin2.93.07.0-2.1-2.3-2.6-0.5-0.61.81.9-0.5
Time to tail flick, vehicle, after self-admin3.64.710.7-2.7-1.5-1.8-1.31.23.32.91.7
Time to tail flick, test, before self-admin1.01.12.7-0.7-0.7-0.80.81.01.11.61.1
Time to tail flick, test, after self-admin0.70.81.2-0.9-0.7-0.4-0.11.01.11.11.1
Delta time to tail flick, vehicle, before/after SA0.90.92.7-0.30.70.7-0.41.40.90.61.6
Delta time to tail flick, test, before/after SA0.50.61.2-0.2-0.8-0.0-0.9-0.9-0.6-1.1-0.9
Tibia length1.12.96.7-1.0-1.2-0.6-2.6-2.5-0.6-1.2-2.4
Ambulatory time before self-admin0.10.20.40.30.60.60.30.30.30.10.5
Ambulatory time after self-admin1.31.64.21.90.91.22.1-0.5-0.5-0.7-1.1
Bone: tissue strength1.21.32.9-1.7-1.4-1.2-1.30.11.20.90.4
Total heroin consumption2.32.75.8-2.2-1.6-1.9-1.0-0.22.41.90.4
Bone: trabecular number0.50.82.90.60.81.00.41.7-0.5-0.40.9
Bone: trabecular spacing0.91.24.7-0.5-1.0-0.9-0.8-2.2-0.1-0.3-1.5
Bone: trabecular thickness1.51.84.11.11.81.70.92.0-0.1-0.01.5
Bone: trabecular tissue density0.50.83.60.80.10.10.4-0.3-1.9-1.2-0.4
Water consumed over 24 hours1.52.09.21.91.20.93.00.8-0.30.30.7
Number of responses in last shaping day2.42.64.71.80.81.20.7-1.7-2.2-2.0-1.9