Limd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	isoform ratio	XM_006247622.5	0.28	0.14	4.3e-03	0.18	0.15	0.06	0.12	1.1e-03	2.5e-03	4.2e-02	7.5e-03
2	NAcc	gene expression	Limd2	0.02	0.01	9.2e-05	0.02	0.03	0.01	0.02	9.6e-04	5.3e-05	8.4e-03	2.6e-04
3	Eye	alternative TSS	XM_006247622.5	0.22	0.12	8.1e-03	0.06	0.08	0	0.03	5.0e-02	2.1e-02	2.7e-01	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.2	0.4	0.4	-0.6	-0.0
Area under the delay curve	0.1	0.1	0.1	-0.3	-0.3	-0.2
BMI with tail	2.0	6.8	10.5	1.7	-3.2	2.6
BMI without tail	3.6	11.1	17.6	2.3	-4.2	3.2
Body weight	4.2	18.5	26.2	3.3	-5.1	4.3
Weight adjusted by age	0.4	0.6	0.9	-1.0	0.7	-0.7
Bone surface	2.5	4.6	5.1	2.3	-2.3	1.9
Bone volume	1.8	3.3	4.3	1.8	-2.1	1.5
Breakpoint value in progressive ratio session	0.3	0.4	0.8	0.9	0.0	0.6
Number of licking bursts	0.1	0.1	0.2	0.4	0.2	-0.0
Context. condit. distance diff. score	0.0	0.0	0.1	0.2	0.3	0.1
Locomotion velocity, session 1	0.3	0.3	0.6	0.2	-0.8	0.5
Locomotion distance, session 1	0.1	0.2	0.4	-0.6	-0.1	-0.4
Locomotion velocity, session 2	0.4	0.4	0.9	1.0	0.1	0.6
Locomotion distance, session 2	0.1	0.2	0.5	-0.2	0.7	-0.4
Locomotion velocity, session 3	0.3	0.4	0.4	-0.6	0.6	-0.6
Locomotion distance, session 3	0.0	0.0	0.1	0.1	0.3	-0.1
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	-1.1	0.6	-1.0
Stereotopy head waving duration, day 3	0.6	0.7	0.8	-0.9	0.7	-0.9
Locomotion velocity, session 7	0.4	0.5	0.6	-0.6	0.7	-0.8
Locomotion distance, session 7	0.1	0.1	0.2	-0.5	0.3	-0.2
Stereotopy head waving bouts, day 7	0.9	1.0	1.5	-0.7	1.2	-1.1
Stereotopy head waving duration, day 7	2.3	2.8	4.5	-1.0	2.1	-1.7
Locomotion velocity, session 8	0.9	1.0	1.4	1.2	-0.6	1.1
Locomotion distance, session 8	0.1	0.1	0.2	0.5	0.4	0.1
Degree of sensitization distance	0.1	0.1	0.2	-0.1	-0.4	0.3
Degree of sensitization stereotypy	1.1	1.2	2.1	-0.7	1.5	-1.1
Conditioned locomotion	0.4	0.5	0.8	0.9	-0.5	0.7
Cocaine response after cond. corrected	0.4	0.5	1.3	-1.1	0.2	-0.5
Cocaine response after cond. not corrected	0.5	0.6	1.0	-1.0	0.7	-0.7
Cocaine response before conditioning	0.2	0.3	0.6	0.4	0.7	-0.4
Saline control response	2.9	3.9	4.7	2.1	-1.6	2.2
Bone: connectivity density	0.4	0.6	0.8	0.9	-0.8	0.5
Bone: cortical apparent density	5.5	7.5	8.9	-2.8	2.3	-3.0
Bone: cortical area	0.6	0.8	2.0	0.3	-1.4	0.7
Bone: cortical porosity	7.7	8.3	9.9	2.7	-2.8	3.1
Bone: cortical porosity	6.0	6.5	7.4	2.2	-2.7	2.7
Bone: cortical thickness	6.4	10.6	16.4	-4.0	2.1	-3.4
Bone: cortical thickness	3.9	4.6	5.3	-2.3	1.8	-2.3
Bone: cortical tissue density	5.2	7.1	8.5	-2.8	2.3	-2.9
Condit. Reinf. active minus inactive responses	3.1	3.5	4.3	2.1	-1.6	1.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.5	1.2	-0.8	1.2
Condit. Reinf. active responses	3.8	4.7	6.3	2.5	-1.8	2.1
Condit. Reinf. inactive responses	1.0	1.2	2.0	1.4	-1.0	0.8
Incentive salience index mean	2.4	2.9	4.0	2.0	-1.4	1.7
Condit. Reinf. lever presses	0.4	0.5	1.0	1.0	-0.3	0.6
Condit. Reinf. active minus inactive responses	4.0	5.2	7.6	2.8	-1.9	2.1
Condit. Reinf. active-inactive response ratio	2.7	3.1	4.8	2.2	-1.4	1.6
Condit. Reinf. active responses	5.5	7.7	10.2	3.2	-2.4	2.7
Condit. Reinf. inactive responses	1.9	2.5	3.1	1.8	-1.4	1.5
Condit. Reinf. lever presses	1.9	2.7	3.3	1.8	-1.4	1.7
Condit. Reinf. lever reinforcers received	4.8	6.7	8.6	2.9	-2.3	2.5
Conditioned reinforcement - actives	0.6	1.0	1.5	0.6	-1.2	1.1
Conditioned reinforcement - inactives	1.2	1.8	2.7	0.9	-1.6	1.4
Conditioned locomotion	3.5	4.5	5.7	1.8	-2.4	2.2
Patch foraging indifference point 0 sec	3.0	5.5	7.1	2.7	-2.3	2.1
Patch foraging indifference point AUC	0.6	0.9	0.9	0.9	-1.0	0.9
Delay disc. indifference point, 0s delay	0.7	0.7	1.0	-0.7	0.9	-1.0
Delay disc. indifference point, 16s delay	0.6	0.7	1.4	0.3	-1.2	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.2	-0.0	-0.5
Delay disc. indifference point, 24s delay	1.6	1.8	3.4	0.8	-1.8	1.2
Delay disc. indifference point, 4s delay	0.8	0.8	1.2	-1.1	0.7	-0.9
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	-0.7	0.1	-0.8
Indifference point function ln k	0.3	0.6	0.7	-0.8	0.6	-0.9
Indifference point function log k	0.3	0.6	0.7	-0.8	0.6	-0.9
Patch foraging total patch changes 0 sec	3.1	5.9	6.9	2.6	-2.4	2.2
Patch foraging total patch changes 12 sec	4.2	5.4	8.1	2.8	-1.8	2.2
Patch foraging total patch changes 18 sec	3.0	4.6	5.2	2.3	-2.0	2.1
Patch foraging total patch changes 24 sec	1.9	3.3	4.0	2.0	-1.9	1.6
Patch foraging total patch changes 6 sec	2.0	3.1	3.3	1.8	-1.8	1.7
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.3	0.6	-0.3
Patch foraging water rate 0 sec	1.3	2.8	4.2	1.4	-2.1	1.5
Patch foraging water rate 12 sec	0.6	1.3	2.2	-1.5	0.6	-1.2
Patch foraging water rate 18 sec	0.2	0.4	0.6	-0.5	0.5	-0.8
Patch foraging water rate 24 sec	0.1	0.1	0.1	-0.2	0.3	-0.3
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.4	-0.2	-0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.3	0.1	-0.5	0.5
Distance traveled before self-admin	0.3	0.4	0.5	-0.6	0.7	-0.6
Distance traveled after self-admin	0.1	0.1	0.3	0.2	0.6	-0.0
Extensor digitorum longus weight	0.1	0.6	1.4	-1.2	0.2	-0.5
Bone: elastic displacement	2.0	2.3	3.2	-1.8	1.2	-1.6
Bone: elastic work	0.2	0.2	0.4	-0.6	-0.4	-0.2
Bone: endosteal estimation	15.6	34.2	40.0	6.3	-5.2	5.9
Bone: endosteal perimeter	17.2	36.6	38.7	6.2	-5.7	6.2
Epididymis fat weight	0.4	1.5	2.4	0.7	-1.5	1.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.4	-0.7	0.5	-0.6
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	0.0	0.1
Diff in mean of infusions in LGA sessions	1.3	1.6	1.9	-1.2	1.4	-1.2
Delay discount exponential model param	0.1	0.1	0.2	0.2	0.5	0.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	0.1	0.2
Active lever presses in extinction session 6	2.3	2.3	2.5	1.6	-1.4	1.6
Bone: final force	0.1	0.1	0.4	-0.1	-0.6	0.1
Bone: final moment	0.1	0.1	0.4	-0.1	-0.6	0.0
Food consumed during 24 hour testing period	3.5	4.8	5.5	1.9	-2.4	2.3
Glucose	0.9	1.5	2.5	-1.6	1.0	-1.0
Heart weight	0.4	0.6	1.4	-1.2	-0.2	-0.5
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	0.4	0.1
Intermittent access intake day 1-15 change	0.1	0.2	0.4	0.4	-0.3	0.7
Intermittent access intake escalation	0.4	0.9	1.3	0.8	-0.9	1.2
Intermittent access intake escalation 2	1.0	1.1	1.6	0.9	-1.0	1.3
Intermitt. access day 1 inactive lever presses	1.2	4.6	5.4	2.3	-2.0	2.1
Intermitt. access day 15 inactive lever presses	1.6	3.3	4.2	1.8	-2.0	1.7
Intermitt. access escalation Index	1.9	2.7	3.5	-1.5	1.9	-1.5
Intermittent access day 1 total infusions	0.5	0.8	1.0	1.0	-0.9	0.9
Intermittent access day 15 total infusions	2.2	3.3	3.6	1.6	-1.9	1.9
Intermittent access terminal intake (last 3 days)	3.7	4.9	5.2	2.1	-2.2	2.3
Intermittent access total infusions	2.9	3.5	3.6	1.9	-1.8	1.9
Intermittent access day 1 locomotion	3.8	4.9	5.9	1.9	-2.4	2.2
Intermittent access day 15 total locomotion	4.2	7.6	7.9	2.7	-2.7	2.8
Intermittent access total locomotion	7.6	9.1	9.6	2.9	-3.1	3.1
Intermittent access standard deviation	0.6	1.2	1.3	1.1	-1.1	1.1
Left kidney weight	0.2	0.7	1.1	-0.8	0.6	-1.1
Right kidney weight	0.1	0.3	0.5	-0.5	0.1	-0.7
Cocaine induced anxiety	0.5	0.8	1.1	-1.0	0.6	-0.9
Post-drug Anxiety	0.8	0.9	1.3	-1.1	0.6	-1.0
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.1	-0.1
Tail length	2.1	8.2	10.2	2.6	-3.2	2.8
Length with tail	1.6	7.0	8.3	2.4	-2.9	2.6
Length without tail	0.1	0.4	0.6	0.4	-0.8	0.6
Times rat made contact with spout	0.8	0.9	1.1	0.7	-1.0	1.0
Lifetime Intake	3.4	4.1	4.3	2.1	-2.0	2.0
Liver weight, left	3.0	5.0	6.9	2.6	-1.8	2.2
Liver weight, right	1.2	2.1	2.7	-1.7	0.9	-1.6
Locomotor activity	0.4	0.6	0.8	0.9	-0.4	0.9
Locomotor testing distance	1.1	2.0	2.7	1.3	-1.2	1.7
Locomotor testing rearing	1.5	3.0	4.2	1.9	-1.2	2.1
Locomotion in novel chamber	0.2	0.2	0.5	-0.7	0.2	-0.2
Locomotion in novel chamber post-restriction	0.5	0.7	0.9	0.9	-0.9	0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.1	-0.3	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.6	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	2.6	2.7	3.9	-1.3	2.0	-1.5
Bouts of movement, locomotor time 1	0.4	0.4	1.0	-1.0	0.1	-0.5
Total resting periods, locomotor time 1	0.4	0.5	1.1	-1.1	0.1	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.2	0.4	-0.5
Distance moved, locomotor task time 1	0.3	0.5	0.8	0.4	-0.9	0.7
Vertical activity count, locomotor time 1	0.1	0.2	0.4	0.2	-0.7	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.2	0.5	-0.2
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.6	0.0	-0.3
Total resting periods, locomotor time 2	0.2	0.4	0.7	-0.9	0.3	-0.5
Rest time, locomotor task time 2	2.9	3.7	3.8	-1.9	1.9	-2.0
Distance moved, locomotor task time 2	0.5	0.7	0.7	0.8	-0.8	0.9
Vertical activity count, locomotor time 2	2.1	2.9	3.1	1.7	-1.6	1.7
Light reinforcement 1	0.1	0.3	0.7	0.8	-0.4	-0.1
Light reinforcement 2	0.1	0.2	0.3	0.6	-0.5	-0.2
Bone: marrow area	15.1	33.0	38.5	6.2	-5.2	5.8
Bone: maximum diameter	3.6	6.7	7.6	2.5	-2.8	2.5
Bone: maximum force	0.6	1.0	2.4	0.3	-1.5	0.7
Bone: maximum moment	0.6	1.0	2.4	0.4	-1.5	0.7
Mean time between licks in bursts	0.2	0.4	0.9	-0.2	-0.9	0.6
Mean num. licks in bursts	0.3	0.5	1.0	-0.0	-1.0	0.7
Cd content in liver	2.2	2.4	3.1	-1.4	1.8	-1.5
Co content in liver	0.6	0.8	1.5	-0.4	1.2	-0.8
Cu content in liver	0.5	0.5	0.9	1.0	-0.6	0.6
Fe content in liver	0.2	0.3	0.7	0.0	0.9	-0.2
K content in liver	0.2	0.2	0.3	0.6	0.3	-0.0
Mg content in liver	1.1	1.2	2.1	-0.2	1.4	-1.2
Mn content in liver	1.4	1.6	2.4	-0.3	1.6	-1.5
Na content in liver	0.5	0.6	1.4	1.2	0.2	0.5
Rb content in liver	5.1	5.9	8.1	-1.8	2.8	-2.5
Se content in liver	1.3	1.6	2.1	-0.9	1.4	-1.3
Sr content in liver	1.0	0.9	1.1	1.0	-1.0	0.8
Zn content in liver	0.5	0.6	0.7	-0.7	0.8	-0.8
Bone: minimum diameter	13.0	23.8	26.2	4.5	-5.1	4.9
Time in familiar zone, hab. session 1	1.2	1.1	1.4	1.1	-0.9	1.2
Time in novel zone, hab. session 1	1.4	1.4	1.8	-1.3	0.9	-1.3
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.2	-0.5	0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.8	0.4	-0.9	0.4
Locomotion velocity, hab. session 1	0.4	0.6	1.0	0.6	-1.0	0.6
Time in familiar zone, hab. session 2	1.6	1.7	2.5	1.4	-0.8	1.6
Time in novel zone, hab. session 2	2.1	2.1	3.0	-1.7	0.8	-1.7
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.2	0.1	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	-0.4	0.2
Locomotion velocity, hab. session 2	0.0	0.1	0.1	0.2	-0.3	0.0
Novel to familiar place preference ratio	0.3	0.3	0.6	0.2	-0.8	0.5
Novelty place preference	0.1	0.1	0.2	0.0	-0.5	0.3
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	-0.3	0.1
Total zone transitions, NPP test	0.1	0.1	0.3	-0.3	0.3	-0.5
Total locomotion distance, NPP test	0.1	0.1	0.2	0.2	-0.4	0.0
Locomotion velocity, NPP test	0.1	0.1	0.4	0.1	-0.6	0.0
Intraocular pressure	1.6	2.3	4.5	0.6	-2.1	1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.2	0.4	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.4	0.0	0.2
Parametrial fat weight	0.0	0.1	0.2	0.1	-0.5	-0.1
Pavlov. Cond. lever latency	1.3	1.6	1.8	-1.3	1.2	-1.3
Pavlov. Cond. magazine entry latency	3.0	3.9	5.0	2.2	-1.7	1.9
Pavlov. Cond. change in total contacts	2.6	2.7	3.0	1.7	-1.5	1.7
Pavlov. Cond. index score	2.6	3.2	3.9	2.0	-1.6	1.8
Pavlov. Cond. latency score	2.2	2.7	3.3	1.8	-1.4	1.7
Pavlov. Cond. lever contacts	1.9	2.3	2.6	1.6	-1.4	1.6
Pavlov. Cond. magazine entry number	2.1	2.6	3.6	-1.9	1.3	-1.6
Pavlov. Cond. intertrial magazine entries	1.1	1.4	1.5	1.2	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	3.5	1.9	-1.6	1.8
Pavlov. Cond. response bias	2.9	3.6	4.6	2.1	-1.7	1.8
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.9	0.3	-0.6
Pavlov. Cond. magazine entry latency	2.3	2.8	3.7	-1.5	1.9	-1.5
Pavlov. Cond. change in total contacts	0.5	0.7	1.5	1.2	-0.1	0.8
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	0.4	0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	0.6	-0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.8	-0.3	0.5
Pavlov. Cond. magazine entry number	3.7	4.5	5.8	2.0	-2.4	2.0
Pavlov. Cond. intertrial magazine entries	13.3	20.0	23.6	4.2	-4.9	4.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.1	0.6	-0.1
Pavlov. Cond. response bias	0.0	0.1	0.1	0.3	0.3	-0.0
Time in closed arm before self-admin	0.0	0.0	0.1	0.3	0.1	0.0
Time in closed arm after self-admin	0.6	0.6	0.9	-0.6	0.9	-0.7
Time in open arm before self-admin	1.0	1.1	1.6	-1.3	0.8	-1.0
Time in open arm after self-admin	0.2	0.2	0.3	0.2	-0.6	0.5
Bone: periosteal estimation	8.3	17.5	17.7	4.2	-4.2	4.1
Bone: periosteal perimeter	4.3	7.3	8.1	2.6	-2.8	2.7
Bone: post-yield work	1.7	2.4	2.8	1.3	-1.7	1.7
Progressive ratio test 1 active lever presses	2.7	3.4	4.1	1.7	-2.0	1.8
Progressive ratio test 1 breakpoint	3.2	3.9	4.6	1.9	-2.1	1.9
Progressive ratio test 1 inactive lever presses	3.0	4.3	4.5	2.0	-2.1	2.1
Progressive ratio test 2 active lever presses	5.9	6.9	8.1	2.5	-2.8	2.5
Progressive ratio test 2 breakpoint	6.6	7.6	8.8	2.6	-3.0	2.7
Progressive ratio test 2 inactive lever presses	2.6	4.3	5.6	1.9	-2.4	1.9
Incentive Sensitization - Responses	3.2	4.6	5.0	2.0	-2.2	2.1
Incentive Sensitization - Breakpoint	3.5	4.6	4.9	2.0	-2.2	2.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.0	0.7	-0.2
Progressive ratio	0.0	0.0	0.0	0.1	-0.0	0.0
Food seeking constrained by brief footshock	4.1	5.0	6.1	2.5	-1.7	2.4
Seeking ratio, punishment vs. effort	1.7	2.5	2.8	1.7	-1.3	1.7
Retroperitoneal fat weight	0.4	1.8	2.8	1.1	-1.7	1.2
Reaction time number correct	0.5	1.0	1.3	-1.1	0.6	-1.1
Reaction time mean minus median	0.1	0.2	0.5	-0.7	0.2	-0.3
Reaction time mean minus median AUC	0.8	2.1	2.4	-1.6	1.3	-1.5
Reaction time num false alarms	3.2	4.5	5.9	2.4	-1.9	2.0
Reaction time num false alarms AUC	2.9	4.6	6.1	2.5	-1.9	2.0
Reaction time trials correct on left	0.5	1.0	1.3	-1.1	0.6	-1.1
Reaction time trials on left	0.5	1.0	1.3	-1.1	0.6	-1.1
Reaction time mean	1.1	1.8	2.2	-1.2	1.5	-1.3
Reaction time mean AUC	1.4	2.2	2.9	-1.3	1.7	-1.4
Median of all reaction times	1.5	2.1	2.7	-1.2	1.6	-1.4
Reaction time omissions	0.1	0.2	0.3	-0.5	-0.5	-0.1
Reaction time false alarm rate	3.8	5.2	6.8	2.6	-1.9	2.3
Reaction time premature initiation rate	0.9	1.3	1.9	0.9	-1.4	1.1
Reaction time premature initiations	0.3	0.5	1.0	0.4	-1.0	0.5
Std. dev. reaction times	0.4	0.7	0.9	-1.0	0.8	-0.8
Reaction time trials completed	0.5	1.0	1.3	-1.1	0.6	-1.1
Reaction time trials AUC	0.5	1.0	1.3	-1.1	0.6	-1.2
Run reversals in cocaine runway, females	0.4	0.4	0.6	-0.7	-0.7	-0.0
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	-0.2	-0.1
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.4	0.8	-0.9	0.3	-0.5
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.9	0.2	0.1
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.1	-0.3	0.1
Total sessions with >9 infusions	0.4	0.4	0.8	0.3	-0.9	0.6
Short access day 1 total inactive lever presses	2.1	2.8	4.1	1.4	-2.0	1.6
Short access day 10 total inactive lever presses	0.1	0.3	0.7	0.3	-0.9	0.4
Short access day 1 total infusions	0.4	0.5	0.7	0.7	-0.8	0.6
Short access day 10 total infusions	3.3	4.2	4.3	2.0	-2.1	2.1
Short access total infusions	1.6	2.0	2.0	1.4	-1.4	1.4
Short access day 1 locomotion	2.5	3.1	5.5	0.9	-2.3	1.7
Short access day 10 total locomotion	5.0	9.2	9.7	2.9	-3.1	3.1
Short access total locomotion	4.0	4.8	6.4	1.7	-2.5	2.3
One hour access (0.3 mA shock)	1.5	1.7	2.1	1.2	-1.3	1.4
Compulsive drug intake	1.0	1.1	1.2	-1.1	1.0	-1.1
One hour access (shock baseline)	1.7	2.6	2.8	1.6	-1.5	1.7
Social response proportion	0.1	0.1	0.2	-0.5	-0.3	0.1
Social responses	0.2	0.2	0.3	0.4	-0.4	0.5
Social time	0.3	0.5	0.7	-0.0	-0.9	0.8
Soleus weight	0.2	0.7	0.8	0.7	-0.9	0.8
Bone: stiffness	0.1	0.1	0.1	0.3	-0.3	0.3
Tibialis anterior weight	0.6	2.1	2.6	1.2	-1.6	1.5
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.5	-0.6	0.5	-0.7
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	0.1	-0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.3	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.4	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.4	1.2	-1.0	1.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.2	0.5	-0.5
Tibia length	0.1	0.4	0.7	-0.7	0.3	-0.8
Ambulatory time before self-admin	0.1	0.2	0.3	-0.3	0.5	-0.3
Ambulatory time after self-admin	0.1	0.1	0.1	0.4	0.2	0.1
Bone: tissue strength	2.3	2.3	2.9	-1.7	1.3	-1.5
Total heroin consumption	0.3	0.4	0.9	0.9	0.2	0.5
Bone: trabecular number	0.4	0.6	0.9	0.8	-0.9	0.5
Bone: trabecular spacing	0.1	0.1	0.2	-0.0	0.4	0.2
Bone: trabecular thickness	1.2	1.5	3.4	0.7	-1.8	0.8
Bone: trabecular tissue density	2.4	3.5	5.2	-2.3	1.1	-2.0
Water consumed over 24 hours	0.0	0.0	0.1	-0.1	-0.3	0.1
Number of responses in last shaping day	0.3	0.3	0.6	0.1	-0.8	0.5