Hub : Genes

Leng8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative polyA	XM_008758948.3	0.04	0.03	2.1e-03	0.01	0.02	0.02	0.01	1.6e-02	6.9e-03	1.6e-03	3.5e-02
2	PL	alternative polyA	XM_006228220.3	0.04	0.03	2.3e-03	0.01	0.01	0.03	0.01	1.5e-02	8.0e-03	5.8e-04	2.6e-02
3	PL	alternative polyA	NM_001037790.3	0.03	0.03	2.2e-03	0.01	0.01	0.02	0.01	1.2e-02	1.3e-02	1.1e-03	5.3e-02
4	PL	alternative polyA	NM_001037790.3	0.04	0.03	1.9e-03	0.01	0.01	0.03	0.01	1.1e-02	1.6e-02	4.7e-04	4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.2	-0.2	-0.4	0.0	0.4
Area under the delay curve	0.1	0.1	0.3	-0.4	0.4	0.5	-0.2
BMI with tail	0.3	0.9	1.8	-0.4	1.3	0.7	-1.0
BMI without tail	0.1	0.3	0.6	0.2	0.8	-0.1	-0.7
Body weight	1.0	4.0	6.2	2.5	1.5	-2.2	-1.7
Weight adjusted by age	1.0	1.1	2.4	-0.3	-1.6	0.0	1.3
Bone surface	0.8	1.5	2.8	1.4	-0.9	-1.7	0.5
Bone volume	0.6	1.1	2.1	1.2	-0.7	-1.5	0.4
Breakpoint value in progressive ratio session	1.0	1.1	2.1	-1.4	-0.1	1.4	0.4
Number of licking bursts	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3
Context. condit. distance diff. score	0.2	0.2	0.5	-0.7	-0.3	0.5	0.3
Locomotion velocity, session 1	7.5	8.2	9.0	-3.0	-3.0	2.4	3.0
Locomotion distance, session 1	2.7	3.4	7.2	-1.0	-2.7	0.4	2.3
Locomotion velocity, session 2	2.1	2.4	2.8	-1.7	-1.6	1.4	1.6
Locomotion distance, session 2	1.2	1.7	3.8	-0.4	-2.0	-0.0	1.6
Locomotion velocity, session 3	0.3	0.3	0.5	-0.7	-0.4	0.6	0.4
Locomotion distance, session 3	0.8	0.8	1.4	-0.8	-1.2	0.5	1.1
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	0.3	0.7	-0.2	-0.6
Stereotopy head waving duration, day 3	0.3	0.4	0.6	0.5	0.8	-0.4	-0.7
Locomotion velocity, session 7	0.4	0.4	0.6	-0.6	-0.8	0.4	0.7
Locomotion distance, session 7	1.3	1.6	1.8	-1.3	-1.3	1.1	1.3
Stereotopy head waving bouts, day 7	0.9	1.0	1.4	1.2	0.7	-1.1	-0.8
Stereotopy head waving duration, day 7	0.7	0.8	1.2	1.1	0.6	-1.0	-0.7
Locomotion velocity, session 8	1.6	1.9	2.3	-1.5	-1.4	1.2	1.4
Locomotion distance, session 8	0.9	1.3	2.0	-1.1	-1.4	0.7	1.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Degree of sensitization stereotypy	0.7	0.8	1.0	1.0	0.8	-0.9	-0.8
Conditioned locomotion	0.4	0.5	0.7	-0.7	-0.8	0.5	0.8
Cocaine response after cond. corrected	1.9	2.1	4.4	0.9	2.1	-0.3	-1.8
Cocaine response after cond. not corrected	1.1	1.3	1.8	1.3	1.1	-1.1	-1.0
Cocaine response before conditioning	1.9	2.3	4.4	0.8	-2.1	-1.3	1.5
Saline control response	1.5	1.9	2.8	-1.3	-1.7	0.9	1.6
Bone: connectivity density	0.1	0.2	0.2	-0.5	-0.4	0.4	0.4
Bone: cortical apparent density	0.4	0.5	0.8	-0.9	-0.5	0.8	0.6
Bone: cortical area	0.3	0.5	1.0	0.9	0.0	-1.0	-0.2
Bone: cortical porosity	0.4	0.4	0.9	-0.2	0.9	0.4	-0.7
Bone: cortical porosity	0.7	0.7	1.5	0.5	1.2	-0.2	-1.1
Bone: cortical thickness	0.3	0.5	1.0	-1.0	0.1	1.0	0.1
Bone: cortical thickness	0.5	0.5	0.8	-0.7	-0.9	0.4	0.8
Bone: cortical tissue density	0.3	0.4	0.7	-0.8	-0.5	0.7	0.5
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	-0.1	0.3	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.0	-0.2	1.0	0.5	-0.8
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	-0.2	-0.2	0.1
Condit. Reinf. inactive responses	0.9	1.1	2.4	0.4	-1.5	-0.7	1.2
Incentive salience index mean	0.0	0.0	0.1	0.0	-0.2	-0.1	0.2
Condit. Reinf. lever presses	0.2	0.3	0.6	0.2	-0.8	-0.4	0.6
Condit. Reinf. active minus inactive responses	1.3	1.7	2.8	0.9	-1.7	-1.3	1.2
Condit. Reinf. active-inactive response ratio	2.1	2.2	4.4	1.9	-0.8	-2.1	0.3
Condit. Reinf. active responses	1.5	2.1	4.9	0.2	-2.2	-0.7	1.8
Condit. Reinf. inactive responses	0.8	1.0	1.4	-0.9	-1.2	0.6	1.1
Condit. Reinf. lever presses	1.2	1.7	2.6	1.6	0.9	-1.5	-1.0
Condit. Reinf. lever reinforcers received	1.7	2.4	5.5	0.2	-2.4	-0.7	1.9
Conditioned reinforcement - actives	2.4	2.4	3.2	1.8	1.4	-1.6	-1.5
Conditioned reinforcement - inactives	1.2	1.4	2.2	1.1	-1.2	-1.5	0.7
Conditioned locomotion	1.7	2.1	3.2	1.8	1.0	-1.6	-1.2
Patch foraging indifference point 0 sec	0.8	1.2	2.0	-1.4	-0.7	1.3	0.8
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.3	0.5	0.4	-0.4
Delay disc. indifference point, 0s delay	2.1	2.3	2.6	-1.6	-1.5	1.4	1.5
Delay disc. indifference point, 16s delay	3.2	3.3	5.1	1.5	2.3	-1.1	-2.1
Delay disc. indifference point, 2s delay	0.3	0.4	0.7	-0.8	-0.2	0.8	0.3
Delay disc. indifference point, 24s delay	1.2	1.1	2.1	0.7	1.5	-0.4	-1.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.6	0.4	-0.6	-0.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	-0.5	-0.3	0.5	0.3
Indifference point function ln k	1.7	2.4	4.5	0.9	-2.1	-1.4	1.5
Indifference point function log k	1.7	2.4	4.5	0.9	-2.1	-1.4	1.5
Patch foraging total patch changes 0 sec	0.7	1.1	1.7	-1.3	-0.6	1.2	0.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.7	-0.1	0.8	0.3	-0.7
Patch foraging total patch changes 18 sec	0.3	0.4	0.7	-0.8	0.2	0.9	0.0
Patch foraging total patch changes 24 sec	0.6	0.7	1.2	0.7	1.1	-0.4	-1.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.5	0.6	0.7	-0.4
Patch foraging time to switch 0 sec	8.1	12.5	22.0	2.6	4.7	-1.7	-4.3
Patch foraging water rate 0 sec	2.7	4.3	6.7	-1.6	-2.6	1.2	2.5
Patch foraging water rate 12 sec	4.0	6.2	11.9	-1.5	-3.4	0.9	3.1
Patch foraging water rate 18 sec	3.2	4.3	7.4	-1.5	-2.7	1.0	2.6
Patch foraging water rate 24 sec	1.8	2.6	4.7	-1.1	-2.2	0.6	2.0
Patch foraging water rate 6 sec	1.6	2.4	4.4	0.9	-2.1	-1.3	1.6
Seeking ratio, delayed vs. immediate footshock	2.4	2.7	3.0	-1.7	-1.7	1.4	1.7
Distance traveled before self-admin	6.8	7.3	12.2	-2.1	-3.5	1.4	3.3
Distance traveled after self-admin	5.6	6.2	7.5	-2.5	-2.7	2.0	2.7
Extensor digitorum longus weight	0.4	1.6	2.7	1.6	0.8	-1.5	-0.9
Bone: elastic displacement	0.8	0.9	1.4	-1.2	-0.6	1.1	0.7
Bone: elastic work	0.4	0.5	1.0	-0.3	-1.0	0.0	0.8
Bone: endosteal estimation	1.6	3.5	7.2	2.6	-0.2	-2.7	-0.3
Bone: endosteal perimeter	1.0	2.0	4.3	1.9	-0.4	-2.1	-0.1
Epididymis fat weight	0.9	2.1	4.1	1.0	2.0	-0.5	-1.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2
Delta time in open arm before/after self-admin	2.0	1.9	3.8	-0.8	-2.0	0.4	1.7
Diff in mean of infusions in LGA sessions	3.4	3.8	4.3	-2.0	-2.1	1.6	2.1
Delay discount exponential model param	0.1	0.1	0.2	0.3	-0.4	-0.4	0.3
Extinction: sum of active levers before priming	5.1	5.1	6.1	-2.5	-2.1	2.1	2.3
Active lever presses in extinction session 6	2.9	2.8	4.2	1.5	2.0	-1.1	-1.9
Bone: final force	0.9	1.4	2.9	1.6	0.0	-1.7	-0.4
Bone: final moment	0.8	1.3	2.8	1.5	-0.3	-1.7	-0.1
Food consumed during 24 hour testing period	0.5	0.6	1.2	1.0	-0.6	-1.1	0.3
Glucose	1.1	1.7	2.8	-1.7	-0.7	1.6	0.9
Heart weight	0.7	1.0	2.0	0.4	-1.4	-0.7	1.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.1	-0.4	-0.2	0.3
Intermittent access intake day 1-15 change	0.5	0.5	1.1	0.2	-1.1	-0.5	0.8
Intermittent access intake escalation	0.3	0.3	0.6	0.6	-0.5	-0.8	0.3
Intermittent access intake escalation 2	0.5	0.5	1.1	-0.1	-1.1	-0.1	0.9
Intermitt. access day 1 inactive lever presses	3.5	3.8	6.3	2.5	1.0	-2.5	-1.4
Intermitt. access day 15 inactive lever presses	7.0	7.7	12.1	3.5	1.7	-3.3	-2.2
Intermitt. access escalation Index	0.3	0.3	0.6	-0.7	0.2	0.8	-0.1
Intermittent access day 1 total infusions	0.7	0.8	1.3	1.1	0.5	-1.1	-0.6
Intermittent access day 15 total infusions	1.1	1.2	2.4	1.5	0.1	-1.5	-0.5
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.5	1.6	0.4	-1.6	-0.6
Intermittent access total infusions	1.3	1.4	2.5	1.6	0.4	-1.6	-0.6
Intermittent access day 1 locomotion	0.5	0.5	1.1	0.9	-0.1	-1.0	-0.2
Intermittent access day 15 total locomotion	0.3	0.3	0.5	0.4	-0.7	-0.7	0.4
Intermittent access total locomotion	0.8	0.9	1.9	1.2	-0.2	-1.4	-0.1
Intermittent access standard deviation	2.6	2.7	3.1	1.7	1.8	-1.4	-1.7
Left kidney weight	1.6	4.4	9.1	2.8	-0.5	-3.0	-0.2
Right kidney weight	1.7	4.8	9.6	3.0	0.2	-3.1	-0.8
Cocaine induced anxiety	1.4	1.7	3.8	-0.4	-1.9	0.0	1.6
Post-drug Anxiety	0.9	1.0	1.3	1.1	0.9	-1.0	-0.9
Baseline Anxiety	3.9	4.1	7.0	1.6	2.7	-1.0	-2.5
Tail length	0.4	1.3	2.5	1.4	-0.7	-1.6	0.4
Length with tail	0.9	3.5	7.1	2.6	-0.2	-2.7	-0.2
Length without tail	0.5	1.2	2.3	1.5	0.3	-1.5	-0.5
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.5	-0.1	-0.4
Lifetime Intake	0.6	0.7	1.2	1.1	0.3	-1.1	-0.5
Liver weight, left	3.1	4.9	6.3	2.1	2.5	-1.7	-2.5
Liver weight, right	2.3	3.8	4.7	1.9	2.2	-1.5	-2.1
Locomotor activity	0.0	0.0	0.1	0.1	0.3	0.2	-0.1
Locomotor testing distance	0.1	0.2	0.4	0.6	0.4	-0.4	-0.3
Locomotor testing rearing	0.3	0.4	0.8	0.9	-0.0	-0.8	-0.1
Locomotion in novel chamber	0.9	1.1	2.1	-1.4	0.1	1.5	0.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	0.1	0.7	0.1	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.3	-0.4	-0.3	0.3
Change in fecal boli incidents, locomotor task	2.0	1.9	3.9	-1.9	0.1	2.0	0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.0	0.5	0.1	-0.4
Bouts of movement, locomotor time 1	5.5	6.0	8.0	-2.3	-2.8	1.8	2.7
Total resting periods, locomotor time 1	3.2	3.5	3.9	-2.0	-2.0	1.6	2.0
Rest time, locomotor task time 1	0.7	0.8	1.7	1.2	-0.2	-1.3	-0.0
Distance moved, locomotor task time 1	0.3	0.4	0.8	-0.8	0.2	0.9	0.0
Vertical activity count, locomotor time 1	4.4	4.6	7.5	-2.7	-1.4	2.5	1.6
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	-0.4	0.8	0.6	-0.6
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0
Rest time, locomotor task time 2	0.8	1.0	1.0	-1.0	-1.0	0.8	1.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1
Vertical activity count, locomotor time 2	0.4	0.4	0.6	-0.8	-0.5	0.7	0.5
Light reinforcement 1	3.0	5.4	6.0	-2.4	-2.4	2.0	2.4
Light reinforcement 2	1.9	2.5	4.2	-2.0	-0.7	2.0	1.1
Bone: marrow area	1.6	3.5	7.3	2.6	-0.2	-2.7	-0.3
Bone: maximum diameter	0.9	1.7	3.2	1.8	0.3	-1.8	-0.6
Bone: maximum force	1.8	3.1	6.0	2.4	0.3	-2.4	-0.8
Bone: maximum moment	1.6	2.7	5.6	2.2	-0.1	-2.4	-0.4
Mean time between licks in bursts	0.5	0.7	1.3	-1.2	-0.1	1.1	0.3
Mean num. licks in bursts	0.5	0.6	0.7	0.8	0.7	-0.7	-0.8
Cd content in liver	1.1	1.2	2.5	-0.4	-1.6	0.1	1.4
Co content in liver	2.8	3.2	4.1	-1.7	-2.0	1.4	2.0
Cu content in liver	0.2	0.2	0.4	0.6	-0.0	-0.6	-0.1
Fe content in liver	0.7	0.9	1.0	-1.0	-1.0	0.8	1.0
K content in liver	0.2	0.2	0.2	-0.5	-0.5	0.4	0.5
Mg content in liver	0.1	0.1	0.2	-0.1	0.5	0.2	-0.4
Mn content in liver	0.3	0.3	0.6	0.4	0.8	-0.2	-0.7
Na content in liver	1.7	1.7	3.5	-1.8	-0.1	1.9	0.4
Rb content in liver	0.1	0.2	0.3	0.5	0.2	-0.5	-0.3
Se content in liver	0.7	0.9	2.0	-0.1	1.4	0.5	-1.1
Sr content in liver	9.0	8.2	13.9	-3.7	-1.6	3.5	2.0
Zn content in liver	1.3	1.5	2.0	1.1	1.4	-0.8	-1.4
Bone: minimum diameter	1.2	2.3	4.8	2.0	-0.7	-2.2	0.2
Time in familiar zone, hab. session 1	1.7	1.6	3.8	-0.2	-1.9	-0.2	1.6
Time in novel zone, hab. session 1	0.6	0.6	0.9	-0.6	1.0	0.8	-0.6
Total zone transitions, hab. session 1	3.5	4.9	7.5	-1.9	-2.7	1.3	2.6
Total locomotion distance, hab. session 1	2.3	3.3	4.7	-1.7	-2.2	1.2	2.0
Locomotion velocity, hab. session 1	1.7	2.3	3.3	-1.4	-1.8	1.0	1.7
Time in familiar zone, hab. session 2	2.5	2.6	4.9	2.2	0.4	-2.2	-0.7
Time in novel zone, hab. session 2	1.1	1.1	2.3	-1.4	0.1	1.5	0.2
Total zone transitions, hab. session 2	1.2	1.5	3.6	-0.3	-1.9	-0.1	1.6
Total locomotion distance, hab. session 2	1.2	1.6	2.0	-1.2	-1.4	0.9	1.4
Locomotion velocity, hab. session 2	1.5	2.0	2.4	-1.5	-1.5	1.1	1.5
Novel to familiar place preference ratio	0.3	0.3	0.3	0.6	0.5	-0.5	-0.5
Novelty place preference	0.2	0.2	0.3	0.5	0.3	-0.5	-0.3
Time in novel zone, NPP test	0.3	0.3	0.4	0.7	0.3	-0.6	-0.4
Total zone transitions, NPP test	0.6	0.8	1.5	-0.7	-1.2	0.4	1.1
Total locomotion distance, NPP test	0.1	0.1	0.2	0.1	-0.5	-0.2	0.3
Locomotion velocity, NPP test	0.2	0.3	0.8	-0.2	-0.9	0.0	0.7
Intraocular pressure	0.6	0.9	1.1	-1.0	-0.9	0.8	0.9
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.7	0.3	0.7	-0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	-0.8	0.1	0.8	0.1
Parametrial fat weight	1.6	3.0	6.5	-0.6	2.5	1.2	-2.0
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.5	-0.3	0.5	0.4
Pavlov. Cond. magazine entry latency	1.0	1.2	2.2	0.9	1.5	-0.5	-1.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.0	0.3	0.0
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	0.4	0.2	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	0.5	-0.0	-0.4
Pavlov. Cond. lever contacts	1.0	1.1	1.6	1.3	0.9	-1.1	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.0	-0.4	-0.1	0.3
Pavlov. Cond. intertrial magazine entries	3.3	4.0	4.5	-2.1	-2.1	1.7	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.1	0.5	0.1	-0.4
Pavlov. Cond. response bias	1.3	1.6	1.8	1.4	1.3	-1.1	-1.3
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.5	-0.3	-0.7	0.1
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	0.2	1.2	0.1	-1.0
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	-0.4	-0.9	0.2	0.8
Pavlov. Cond. index score	0.1	0.1	0.4	0.2	0.6	0.0	-0.5
Pavlov. Cond. latency score	0.2	0.3	0.6	0.1	0.8	0.1	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.2	0.4	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.1	-0.7	-0.1	0.5
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.8	1.0	-1.1	-1.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.2	0.4	0.0	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	0.1	-0.3	-0.1
Time in closed arm before self-admin	0.4	0.4	0.8	0.9	0.0	-0.9	-0.2
Time in closed arm after self-admin	1.0	1.0	1.1	1.0	1.1	-0.8	-1.1
Time in open arm before self-admin	0.3	0.3	0.4	-0.5	0.6	0.6	-0.4
Time in open arm after self-admin	1.0	1.1	1.4	-1.2	-1.0	1.0	1.0
Bone: periosteal estimation	1.1	2.2	4.7	2.0	-0.2	-2.2	-0.2
Bone: periosteal perimeter	0.6	1.1	2.1	1.3	-0.6	-1.5	0.3
Bone: post-yield work	2.6	3.6	6.4	2.5	0.7	-2.5	-1.0
Progressive ratio test 1 active lever presses	0.5	0.5	1.2	0.0	-1.1	-0.3	0.8
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	0.1	-1.0	-0.4	0.8
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.3	1.2	-1.0	-1.5	0.5
Progressive ratio test 2 active lever presses	1.1	1.2	2.3	1.5	0.2	-1.5	-0.5
Progressive ratio test 2 breakpoint	1.4	1.6	3.0	1.7	0.3	-1.7	-0.6
Progressive ratio test 2 inactive lever presses	1.1	1.3	2.8	1.4	-0.6	-1.7	0.1
Incentive Sensitization - Responses	4.5	4.6	8.1	2.9	0.8	-2.8	-1.2
Incentive Sensitization - Breakpoint	4.4	4.5	7.7	2.8	1.0	-2.7	-1.4
Sum of active levers in priming session hrs 5-6	2.2	2.2	2.5	-1.6	-1.5	1.3	1.5
Progressive ratio	2.5	2.9	4.0	-2.0	-1.5	1.7	1.6
Food seeking constrained by brief footshock	22.8	28.1	31.2	-5.5	-5.6	4.5	5.6
Seeking ratio, punishment vs. effort	1.6	1.9	3.2	-1.0	-1.8	0.7	1.7
Retroperitoneal fat weight	1.3	4.4	8.1	-1.2	2.8	2.0	-2.0
Reaction time number correct	0.2	0.2	0.4	-0.7	-0.3	0.6	0.3
Reaction time mean minus median	0.4	0.6	0.6	0.8	0.7	-0.7	-0.8
Reaction time mean minus median AUC	0.7	0.9	1.0	1.0	1.0	-0.8	-1.0
Reaction time num false alarms	0.0	0.1	0.1	-0.2	-0.3	0.1	0.3
Reaction time num false alarms AUC	1.1	1.5	1.9	-1.4	-1.1	1.2	1.1
Reaction time trials correct on left	0.2	0.2	0.4	-0.7	-0.3	0.6	0.3
Reaction time trials on left	0.2	0.2	0.4	-0.7	-0.3	0.6	0.3
Reaction time mean	1.6	2.2	3.6	1.9	0.9	-1.8	-1.1
Reaction time mean AUC	2.1	2.8	3.8	2.0	1.3	-1.8	-1.5
Median of all reaction times	1.0	1.4	2.4	1.5	0.6	-1.5	-0.8
Reaction time omissions	0.3	0.4	0.5	-0.7	-0.5	0.6	0.5
Reaction time false alarm rate	0.6	0.8	1.0	-1.0	-0.9	0.8	0.9
Reaction time premature initiation rate	0.5	0.7	0.8	0.9	0.8	-0.7	-0.8
Reaction time premature initiations	0.4	0.6	0.8	0.7	0.9	-0.5	-0.9
Std. dev. reaction times	1.6	2.2	3.2	1.8	1.0	-1.7	-1.3
Reaction time trials completed	0.2	0.2	0.4	-0.7	-0.3	0.6	0.3
Reaction time trials AUC	0.0	0.1	0.1	-0.3	-0.0	0.3	0.1
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.8	0.4	-0.8	-0.5
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	0.3	-0.4	-0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.1	-0.6	-0.2	0.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.3	-0.7	0.2	0.6
Latency to leave start box in cocaine runway, M	0.6	0.5	1.0	1.0	0.1	-1.0	-0.3
Std. dev. time between licks in bursts	4.1	4.9	5.8	-2.2	-2.3	1.9	2.4
Total sessions with >9 infusions	1.1	1.2	2.7	1.5	0.0	-1.6	-0.4
Short access day 1 total inactive lever presses	3.5	3.9	5.4	2.3	1.6	-2.1	-1.8
Short access day 10 total inactive lever presses	0.6	0.6	1.1	1.0	0.4	-1.0	-0.5
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.4	0.1	0.3
Short access day 10 total infusions	0.2	0.2	0.2	0.5	0.5	-0.4	-0.5
Short access total infusions	0.1	0.1	0.3	-0.5	-0.1	0.5	0.1
Short access day 1 locomotion	0.4	0.4	0.8	0.8	-0.0	-0.9	-0.2
Short access day 10 total locomotion	1.2	1.3	2.7	-0.7	-1.6	0.3	1.4
Short access total locomotion	1.5	1.6	2.1	-1.2	-1.5	0.9	1.4
One hour access (0.3 mA shock)	2.1	2.4	4.9	2.1	0.1	-2.2	-0.6
Compulsive drug intake	0.3	0.3	0.6	0.5	-0.5	-0.8	0.2
One hour access (shock baseline)	3.3	3.8	5.6	2.4	1.5	-2.1	-1.7
Social response proportion	1.0	1.1	2.0	1.4	0.6	-1.2	-0.6
Social responses	0.7	0.9	1.5	0.7	-1.2	-0.9	0.9
Social time	4.8	6.4	12.7	-1.4	-3.6	0.7	3.2
Soleus weight	0.0	0.1	0.2	0.4	0.2	-0.3	-0.2
Bone: stiffness	1.5	2.4	4.6	2.1	0.3	-2.1	-0.7
Tibialis anterior weight	1.0	3.4	6.6	1.2	2.6	-0.6	-2.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.3	-0.7	-0.5	0.4
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.3	1.5	0.6	-1.5	-0.8
Time to tail flick, test, before self-admin	6.8	6.6	9.5	-2.3	-3.1	1.7	2.9
Time to tail flick, test, after self-admin	0.3	0.3	0.3	0.5	0.6	-0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.4	1.1	1.2	-0.8	-1.2
Delta time to tail flick, test, before/after SA	3.5	3.2	4.1	1.7	2.0	-1.3	-2.0
Tibia length	1.8	5.0	10.3	3.0	-0.0	-3.2	-0.6
Ambulatory time before self-admin	3.4	3.5	6.5	-1.2	-2.6	0.7	2.3
Ambulatory time after self-admin	6.7	7.4	10.8	-2.4	-3.3	1.8	3.1
Bone: tissue strength	1.2	1.2	1.6	-1.0	-1.2	0.8	1.2
Total heroin consumption	0.6	0.7	1.3	-1.1	-0.1	1.1	0.3
Bone: trabecular number	0.4	0.7	0.9	-1.0	-0.7	0.8	0.7
Bone: trabecular spacing	0.3	0.4	0.6	0.5	0.8	-0.4	-0.8
Bone: trabecular thickness	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Bone: trabecular tissue density	1.6	2.3	4.7	0.8	2.2	-0.4	-1.9
Water consumed over 24 hours	1.1	1.3	2.6	-0.5	-1.6	0.2	1.5
Number of responses in last shaping day	0.4	0.4	0.7	0.8	0.4	-0.8	-0.5