Hub : Genes

Lama1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Lama1 0.04 0.03 7.4e-04 0.04 0.03 0.02 0.03 2.0e-04 1.4e-03 8.1e-03 1.8e-03
2 IL gene expression Lama1 0.27 0.15 2.2e-04 0.19 0.17 0.17 0.18 2.4e-05 7.3e-05 5.6e-05 5.1e-05
3 Brain gene expression Lama1 0.16 0.08 1.7e-10 0.12 0.11 0.12 0.12 1.3e-11 2.5e-10 3.8e-11 2.1e-11
4 IC gene expression Lama1 0.3 0.14 1.7e-06 0.13 0.12 0.14 0.03 3.4e-06 1.1e-05 2.5e-06 1.6e-02
5 Adipose gene expression Lama1 0.42 0.14 0.0e+00 0.19 0.17 0.19 0.19 6.0e-21 4.6e-19 2.3e-20 1.6e-20
6 pVTA gene expression Lama1 0.14 0.09 4.9e-07 0.08 0.04 0.07 0.03 3.0e-07 6.8e-04 2.2e-06 1.5e-03
7 PL mRNA stability Lama1 0.06 0.04 4.3e-04 0.04 0.03 0.04 0.02 1.4e-05 7.7e-04 5.3e-05 3.1e-03
8 NAcc gene expression Lama1 0.25 0.08 0.0e+00 0.18 0.05 0.17 0.06 2.0e-26 1.2e-07 1.2e-24 1.1e-09
9 BLA gene expression Lama1 0.6 0.06 7.6e-12 0.22 0.22 0.21 0.22 7.9e-12 4.6e-12 1.5e-11 5.7e-12
10 OFC gene expression Lama1 0.46 0.17 6.0e-05 0.23 0.18 0.21 0.22 3.2e-06 4.1e-05 9.0e-06 5.6e-06
11 PL gene expression Lama1 0.22 0.11 1.5e-08 0.09 0.02 0.08 0.03 1.5e-09 9.8e-04 5.5e-09 1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density6.110.611.53.3-3.3-3.3-3.3-3.4-3.23.4-3.2-2.9-3.2-3.2
Area under the delay curve1.21.41.9-1.21.31.21.11.01.4-1.01.31.21.11.1
BMI with tail3.110.811.8-3.43.43.43.33.23.3-3.23.23.03.33.3
BMI without tail1.23.74.3-2.12.02.01.91.92.0-1.92.01.71.91.9
Body weight4.720.722.8-4.84.84.84.64.54.6-4.54.54.24.44.4
Weight adjusted by age0.10.20.40.5-0.5-0.5-0.4-0.5-0.40.5-0.2-0.6-0.2-0.2
Bone surface4.47.98.32.9-2.9-2.9-2.9-2.9-2.82.9-2.8-2.5-2.8-2.8
Bone volume6.511.612.73.5-3.4-3.4-3.5-3.6-3.43.6-3.3-3.2-3.4-3.4
Breakpoint value in progressive ratio session0.30.30.6-0.60.60.60.50.40.5-0.50.80.30.60.6
Number of licking bursts0.10.20.3-0.50.50.40.40.50.3-0.50.30.20.30.3
Context. condit. distance diff. score0.00.00.30.1-0.1-0.1-0.1-0.1-0.10.2-0.0-0.5-0.0-0.0
Locomotion velocity, session 10.91.01.31.1-1.1-1.1-1.0-1.1-1.01.1-0.8-1.0-0.8-0.8
Locomotion distance, session 10.60.81.2-0.80.80.80.90.80.8-0.81.01.11.01.0
Locomotion velocity, session 20.00.00.2-0.10.10.10.20.20.1-0.20.10.50.10.1
Locomotion distance, session 20.70.91.6-0.90.90.91.00.90.9-0.91.01.31.01.0
Locomotion velocity, session 31.31.51.81.3-1.3-1.3-1.2-1.3-1.11.3-1.0-1.3-1.0-1.0
Locomotion distance, session 30.50.50.6-0.70.70.70.80.80.8-0.70.80.50.80.8
Stereotopy head waving bouts, day 34.04.75.02.2-2.2-2.2-2.2-2.2-2.12.2-2.1-2.1-2.1-2.1
Stereotopy head waving duration, day 39.811.712.43.5-3.5-3.5-3.4-3.4-3.43.3-3.4-3.5-3.4-3.4
Locomotion velocity, session 70.50.60.6-0.80.80.80.80.80.8-0.80.80.70.80.8
Locomotion distance, session 72.12.63.0-1.61.61.61.71.71.7-1.61.61.41.61.6
Stereotopy head waving bouts, day 70.10.10.10.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.2-0.3-0.3
Stereotopy head waving duration, day 70.80.91.01.0-1.0-1.0-1.0-1.0-1.00.9-0.9-0.9-0.9-0.9
Locomotion velocity, session 80.40.50.70.8-0.8-0.8-0.7-0.8-0.70.9-0.6-0.5-0.6-0.6
Locomotion distance, session 80.00.00.1-0.10.10.10.20.10.2-0.10.3-0.10.30.3
Degree of sensitization distance0.40.40.5-0.70.70.70.60.70.6-0.70.60.70.60.6
Degree of sensitization stereotypy0.20.20.3-0.50.50.50.50.50.5-0.50.50.50.50.5
Conditioned locomotion1.51.82.1-1.41.41.41.31.31.4-1.31.41.01.31.3
Cocaine response after cond. corrected4.14.95.5-2.32.32.32.32.42.2-2.32.12.12.12.1
Cocaine response after cond. not corrected7.28.49.4-3.03.03.13.03.02.8-3.02.82.72.72.7
Cocaine response before conditioning0.70.81.0-1.00.91.00.90.90.9-0.80.90.60.90.9
Saline control response0.40.50.70.6-0.7-0.7-0.7-0.6-0.70.6-0.7-0.9-0.7-0.7
Bone: connectivity density3.75.86.52.5-2.6-2.6-2.5-2.5-2.32.5-2.3-1.8-2.3-2.3
Bone: cortical apparent density3.34.54.8-2.12.12.12.22.22.2-2.22.12.02.22.2
Bone: cortical area0.00.00.3-0.0-0.0-0.00.00.0-0.1-0.0-0.0-0.6-0.0-0.0
Bone: cortical porosity0.20.20.30.4-0.4-0.4-0.5-0.6-0.40.6-0.4-0.5-0.4-0.4
Bone: cortical porosity0.00.00.00.1-0.1-0.1-0.1-0.2-0.10.2-0.1-0.2-0.1-0.1
Bone: cortical thickness0.30.50.6-0.80.70.70.70.70.7-0.70.70.00.70.7
Bone: cortical thickness1.01.11.5-1.11.11.11.11.21.1-1.21.00.51.01.0
Bone: cortical tissue density3.64.95.1-2.22.22.22.22.32.2-2.32.22.12.22.2
Condit. Reinf. active minus inactive responses1.82.12.2-1.51.51.51.41.41.5-1.31.51.21.51.5
Condit. Reinf. active-inactive response ratio2.72.93.0-1.71.71.71.71.71.7-1.71.71.61.71.7
Condit. Reinf. active responses1.31.61.9-1.31.31.31.21.21.4-1.11.41.21.41.4
Condit. Reinf. inactive responses0.30.30.50.6-0.6-0.6-0.6-0.7-0.50.7-0.5-0.4-0.5-0.5
Incentive salience index mean1.72.12.4-1.41.41.41.41.41.5-1.41.51.41.51.5
Condit. Reinf. lever presses0.10.10.3-0.30.30.30.30.20.4-0.30.40.50.40.4
Condit. Reinf. active minus inactive responses2.12.72.9-1.71.61.61.71.71.7-1.71.71.31.71.7
Condit. Reinf. active-inactive response ratio4.04.64.9-2.22.22.22.12.12.2-2.12.22.12.22.2
Condit. Reinf. active responses0.50.81.0-0.90.80.80.90.90.9-0.91.00.21.01.0
Condit. Reinf. inactive responses0.71.02.41.0-1.0-1.0-0.9-0.9-1.00.9-0.8-1.6-0.8-0.8
Condit. Reinf. lever presses0.20.20.4-0.50.40.40.50.60.4-0.60.5-0.00.50.5
Condit. Reinf. lever reinforcers received0.60.81.0-0.90.80.80.90.90.9-0.91.00.31.01.0
Conditioned reinforcement - actives0.00.00.20.2-0.2-0.2-0.2-0.2-0.20.1-0.0-0.4-0.0-0.0
Conditioned reinforcement - inactives2.74.04.2-2.02.02.02.02.02.0-2.02.01.82.12.1
Conditioned locomotion1.62.12.31.5-1.5-1.5-1.5-1.5-1.51.4-1.4-1.4-1.4-1.4
Patch foraging indifference point 0 sec0.10.20.40.4-0.4-0.5-0.4-0.4-0.40.4-0.5-0.3-0.6-0.6
Patch foraging indifference point AUC0.10.20.7-0.30.30.30.30.20.5-0.20.40.80.40.4
Delay disc. indifference point, 0s delay0.00.00.1-0.0-0.00.0-0.2-0.2-0.00.2-0.20.0-0.3-0.3
Delay disc. indifference point, 16s delay0.91.01.1-1.01.01.01.01.01.1-1.01.01.00.90.9
Delay disc. indifference point, 2s delay0.91.01.6-1.01.01.00.80.71.1-0.71.21.31.01.0
Delay disc. indifference point, 24s delay1.01.11.41.0-1.0-1.0-1.1-1.1-0.91.1-1.0-0.8-1.2-1.2
Delay disc. indifference point, 4s delay2.12.22.6-1.51.51.51.41.41.6-1.41.61.41.51.5
Delay disc. indifference point, 8s delay0.80.91.2-1.01.11.00.90.81.1-0.81.01.00.90.9
Indifference point function ln k1.62.94.61.6-1.6-1.6-1.7-1.6-1.71.6-1.7-2.1-1.7-1.7
Indifference point function log k1.62.94.61.6-1.6-1.6-1.7-1.6-1.71.6-1.7-2.1-1.7-1.7
Patch foraging total patch changes 0 sec0.10.30.50.5-0.4-0.5-0.5-0.5-0.40.5-0.6-0.3-0.7-0.7
Patch foraging total patch changes 12 sec0.00.00.10.1-0.2-0.2-0.1-0.2-0.00.2-0.10.3-0.2-0.2
Patch foraging total patch changes 18 sec0.00.10.30.1-0.1-0.2-0.2-0.30.10.3-0.00.6-0.1-0.1
Patch foraging total patch changes 24 sec1.52.64.3-1.61.61.51.61.61.5-1.71.52.11.51.5
Patch foraging total patch changes 6 sec0.10.10.20.3-0.2-0.3-0.4-0.4-0.20.4-0.40.4-0.4-0.4
Patch foraging time to switch 0 sec0.10.20.3-0.50.40.40.50.50.5-0.50.50.50.50.5
Patch foraging water rate 0 sec0.10.10.2-0.40.50.40.40.40.3-0.40.30.30.30.3
Patch foraging water rate 12 sec0.20.30.5-0.70.70.70.50.50.5-0.50.50.60.50.5
Patch foraging water rate 18 sec0.40.60.8-0.80.90.90.80.90.6-0.90.60.80.70.7
Patch foraging water rate 24 sec0.00.10.1-0.30.30.20.20.20.3-0.20.20.30.20.2
Patch foraging water rate 6 sec0.71.01.2-1.11.11.11.01.01.0-1.00.90.91.01.0
Seeking ratio, delayed vs. immediate footshock0.00.00.2-0.00.00.0-0.00.10.1-0.1-0.4-0.2-0.3-0.3
Distance traveled before self-admin0.60.81.01.0-1.0-1.0-0.9-1.0-0.90.9-0.8-0.8-0.8-0.8
Distance traveled after self-admin0.50.71.00.9-0.9-0.9-0.8-0.9-0.80.8-0.7-1.0-0.6-0.6
Extensor digitorum longus weight0.41.52.2-1.31.31.21.21.11.2-1.11.21.51.21.2
Bone: elastic displacement0.40.50.6-0.80.70.70.70.60.7-0.60.80.40.80.8
Bone: elastic work0.10.10.30.2-0.2-0.2-0.3-0.4-0.30.4-0.3-0.6-0.3-0.3
Bone: endosteal estimation1.12.32.81.5-1.5-1.5-1.5-1.5-1.61.5-1.5-1.7-1.6-1.6
Bone: endosteal perimeter1.22.62.81.6-1.6-1.6-1.6-1.6-1.71.6-1.6-1.6-1.6-1.6
Epididymis fat weight0.82.93.5-1.81.71.81.71.61.8-1.61.61.91.61.6
Delta time in closed arm before/after self-admin0.10.10.2-0.30.30.30.30.30.3-0.40.20.40.10.1
Delta time in open arm before/after self-admin1.21.21.5-1.11.11.11.11.11.1-1.11.20.81.11.1
Diff in mean of infusions in LGA sessions0.60.81.20.9-0.9-0.9-1.0-1.1-0.91.1-0.7-0.5-0.7-0.7
Delay discount exponential model param1.41.62.11.3-1.3-1.3-1.2-1.1-1.41.1-1.4-1.3-1.2-1.2
Extinction: sum of active levers before priming0.91.01.7-1.01.01.00.90.80.9-0.91.11.30.90.9
Active lever presses in extinction session 61.11.11.6-1.11.11.10.90.81.0-0.81.21.01.31.3
Bone: final force0.40.61.30.7-0.7-0.7-0.7-0.8-0.80.8-0.7-1.1-0.7-0.7
Bone: final moment0.30.51.10.6-0.5-0.5-0.6-0.7-0.70.7-0.6-1.0-0.7-0.7
Food consumed during 24 hour testing period0.00.00.20.2-0.1-0.2-0.2-0.1-0.10.1-0.1-0.5-0.1-0.1
Glucose0.40.71.10.7-0.7-0.6-0.8-0.7-0.90.6-1.0-1.0-0.9-0.9
Heart weight2.84.45.1-2.12.12.12.22.32.2-2.21.92.11.91.9
Delay discount hyperbolic model param1.51.72.11.3-1.4-1.3-1.2-1.1-1.51.1-1.5-1.3-1.3-1.3
Intermittent access intake day 1-15 change0.20.50.60.7-0.7-0.7-0.7-0.7-0.70.7-0.7-0.5-0.8-0.8
Intermittent access intake escalation0.20.40.50.7-0.7-0.7-0.6-0.6-0.60.6-0.7-0.3-0.7-0.7
Intermittent access intake escalation 20.00.00.3-0.10.10.10.10.10.2-0.1-0.00.50.00.0
Intermitt. access day 1 inactive lever presses0.10.60.8-0.70.70.70.80.80.8-0.70.70.90.70.7
Intermitt. access day 15 inactive lever presses1.63.33.6-1.91.91.91.91.81.9-1.81.71.61.81.8
Intermitt. access escalation Index0.10.20.20.4-0.4-0.4-0.4-0.5-0.40.4-0.3-0.2-0.4-0.4
Intermittent access day 1 total infusions0.10.10.2-0.30.30.30.30.20.2-0.30.5-0.00.50.5
Intermittent access day 15 total infusions0.00.00.1-0.10.10.10.20.10.2-0.20.40.10.30.3
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.4-0.4-0.4-0.4-0.30.3-0.2-0.4-0.2-0.2
Intermittent access total infusions0.10.20.3-0.30.30.30.40.30.3-0.40.60.20.60.6
Intermittent access day 1 locomotion0.10.10.2-0.20.20.20.20.20.2-0.20.40.10.40.4
Intermittent access day 15 total locomotion0.10.10.2-0.30.30.30.40.30.3-0.40.40.20.40.4
Intermittent access total locomotion0.10.10.2-0.30.30.30.30.20.2-0.30.50.20.40.4
Intermittent access standard deviation2.14.34.6-2.02.02.02.12.12.1-2.12.12.02.12.1
Left kidney weight4.922.924.7-4.95.04.94.84.84.8-4.84.84.64.64.6
Right kidney weight7.031.733.8-5.85.85.85.75.75.7-5.65.55.65.45.4
Cocaine induced anxiety0.00.10.1-0.20.20.20.20.30.3-0.30.30.10.30.3
Post-drug Anxiety0.20.20.2-0.40.40.40.40.40.4-0.40.50.40.50.5
Baseline Anxiety0.00.00.1-0.30.30.30.20.20.2-0.10.20.40.20.2
Tail length0.41.51.7-1.21.21.21.21.21.2-1.21.31.31.21.2
Length with tail1.25.46.1-2.42.52.42.32.42.3-2.42.32.32.22.2
Length without tail3.711.813.3-3.53.63.63.43.53.3-3.53.33.43.33.3
Times rat made contact with spout0.00.00.1-0.00.0-0.0-0.0-0.00.10.00.1-0.30.00.0
Lifetime Intake0.10.10.3-0.30.30.30.30.30.3-0.40.50.10.50.5
Liver weight, left0.30.60.8-0.70.70.70.70.50.9-0.50.80.80.90.9
Liver weight, right0.00.10.2-0.30.30.30.30.20.4-0.20.3-0.20.30.3
Locomotor activity0.10.10.2-0.30.40.40.30.30.4-0.30.30.20.30.3
Locomotor testing distance0.10.10.20.4-0.3-0.3-0.3-0.4-0.20.4-0.3-0.3-0.3-0.3
Locomotor testing rearing2.65.26.32.3-2.3-2.3-2.4-2.5-2.12.5-2.1-2.5-2.1-2.1
Locomotion in novel chamber2.53.23.3-1.81.81.81.81.71.8-1.71.71.81.81.8
Locomotion in novel chamber post-restriction0.10.20.3-0.50.50.50.40.40.4-0.40.60.60.50.5
Fecal boli incidents, locomotor time 10.10.10.4-0.30.30.30.30.30.4-0.30.30.60.30.3
Change in fecal boli incidents, locomotor task0.30.30.40.5-0.6-0.6-0.5-0.4-0.60.4-0.5-0.6-0.5-0.5
Time >=10cm from walls, locomotor time 10.80.91.00.9-1.0-1.0-0.9-0.9-1.00.9-0.9-0.9-0.9-0.9
Bouts of movement, locomotor time 10.00.00.1-0.10.10.10.30.40.1-0.40.1-0.20.10.1
Total resting periods, locomotor time 10.10.10.3-0.40.30.30.50.50.4-0.50.30.10.30.3
Rest time, locomotor task time 10.10.20.2-0.40.40.40.40.50.4-0.50.40.20.40.4
Distance moved, locomotor task time 11.01.51.91.1-1.1-1.1-1.2-1.2-1.11.2-1.3-1.1-1.4-1.4
Vertical activity count, locomotor time 10.40.81.10.8-0.8-0.8-0.9-0.9-0.90.9-1.0-1.0-1.0-1.0
Time >=10cm from walls, locomotor time 20.20.20.30.4-0.5-0.5-0.5-0.6-0.50.6-0.5-0.4-0.5-0.5
Bouts of movement, locomotor time 21.62.52.71.6-1.6-1.6-1.6-1.6-1.61.6-1.5-1.6-1.6-1.6
Total resting periods, locomotor time 20.61.01.41.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.2-1.0-1.0
Rest time, locomotor task time 20.40.40.8-0.70.70.70.80.90.6-0.90.50.30.60.6
Distance moved, locomotor task time 21.31.52.11.1-1.1-1.1-1.4-1.5-1.11.5-1.2-1.1-1.3-1.3
Vertical activity count, locomotor time 21.21.61.91.1-1.2-1.2-1.3-1.3-1.21.3-1.4-1.3-1.4-1.4
Light reinforcement 10.30.70.90.7-0.9-0.8-0.8-0.7-0.80.7-0.9-1.0-0.8-0.8
Light reinforcement 20.10.10.2-0.30.20.20.30.50.2-0.40.20.20.20.2
Bone: marrow area1.02.22.51.5-1.5-1.5-1.4-1.4-1.61.4-1.4-1.6-1.5-1.5
Bone: maximum diameter0.50.81.20.9-0.9-0.9-0.9-0.9-1.00.9-0.8-1.1-0.9-0.9
Bone: maximum force0.00.00.30.0-0.0-0.0-0.1-0.1-0.10.1-0.1-0.5-0.1-0.1
Bone: maximum moment0.00.00.2-0.10.10.10.1-0.0-0.00.00.1-0.50.00.0
Mean time between licks in bursts0.00.00.20.2-0.3-0.3-0.2-0.2-0.10.2-0.2-0.4-0.1-0.1
Mean num. licks in bursts0.00.00.00.2-0.2-0.1-0.2-0.2-0.00.20.0-0.2-0.0-0.0
Cd content in liver0.60.70.9-0.80.70.80.90.80.7-0.80.90.60.90.9
Co content in liver1.01.11.4-1.01.11.01.11.11.2-1.11.10.61.11.1
Cu content in liver2.83.43.7-1.81.91.81.91.91.8-1.91.81.71.81.8
Fe content in liver0.81.01.41.1-1.2-1.1-1.0-1.2-0.91.2-0.7-1.1-0.6-0.6
K content in liver0.00.00.0-0.0-0.00.0-0.0-0.10.10.1-0.0-0.10.10.1
Mg content in liver0.30.40.5-0.70.60.70.60.70.7-0.70.50.30.50.5
Mn content in liver1.51.62.31.1-1.2-1.1-1.3-1.1-1.21.1-1.4-1.5-1.4-1.4
Na content in liver0.60.60.80.9-0.9-0.9-0.8-0.9-0.80.9-0.6-0.9-0.5-0.5
Rb content in liver0.70.81.0-0.90.90.90.90.90.9-0.90.81.00.80.8
Se content in liver0.00.00.20.1-0.2-0.1-0.1-0.2-0.10.2-0.0-0.4-0.0-0.0
Sr content in liver0.10.10.20.4-0.4-0.4-0.3-0.4-0.40.4-0.2-0.1-0.2-0.2
Zn content in liver1.31.42.1-1.31.21.31.31.41.1-1.41.01.11.01.0
Bone: minimum diameter0.10.20.50.4-0.4-0.4-0.3-0.3-0.50.3-0.5-0.7-0.5-0.5
Time in familiar zone, hab. session 14.34.14.32.0-2.0-2.0-2.1-2.0-2.02.1-2.0-2.1-2.0-2.0
Time in novel zone, hab. session 11.61.61.7-1.31.31.31.31.31.2-1.31.31.21.31.3
Total zone transitions, hab. session 10.00.00.1-0.20.20.20.20.10.2-0.10.20.30.20.2
Total locomotion distance, hab. session 12.53.53.7-1.91.91.91.91.91.8-1.91.91.61.91.9
Locomotion velocity, hab. session 11.21.71.9-1.31.31.31.31.41.2-1.31.31.11.31.3
Time in familiar zone, hab. session 22.12.22.81.5-1.5-1.5-1.6-1.6-1.41.7-1.3-1.3-1.3-1.3
Time in novel zone, hab. session 20.60.61.0-0.80.80.80.91.00.7-1.00.60.60.60.6
Total zone transitions, hab. session 20.10.10.1-0.40.40.40.40.40.3-0.30.30.30.30.3
Total locomotion distance, hab. session 22.12.72.9-1.71.71.71.71.71.6-1.71.71.51.71.7
Locomotion velocity, hab. session 22.93.94.1-2.02.02.02.02.01.9-2.02.01.82.02.0
Novel to familiar place preference ratio0.70.71.0-0.90.90.90.91.00.8-1.00.80.60.80.8
Novelty place preference0.60.60.9-0.90.90.90.80.90.7-0.90.70.60.70.7
Time in novel zone, NPP test0.40.40.6-0.70.70.70.70.70.6-0.80.60.40.60.6
Total zone transitions, NPP test0.60.91.0-0.90.90.91.01.00.9-1.01.00.81.01.0
Total locomotion distance, NPP test2.22.93.4-1.81.81.81.81.81.7-1.81.71.31.71.7
Locomotion velocity, NPP test2.53.64.2-1.91.91.92.02.01.8-2.01.81.61.81.8
Intraocular pressure1.01.51.71.2-1.1-1.2-1.3-1.3-1.31.3-1.3-1.0-1.2-1.2
Delta distance traveled before/after self-admin0.10.10.40.3-0.3-0.3-0.3-0.2-0.20.3-0.3-0.6-0.3-0.3
Delta ambulatory time before/after self-admin0.00.00.30.1-0.1-0.1-0.1-0.0-0.10.1-0.1-0.6-0.1-0.1
Parametrial fat weight1.02.32.5-1.61.51.51.61.61.6-1.61.51.21.41.4
Pavlov. Cond. lever latency1.31.62.31.2-1.2-1.2-1.2-1.2-1.31.1-1.3-1.5-1.3-1.3
Pavlov. Cond. magazine entry latency0.20.20.40.4-0.4-0.4-0.5-0.5-0.30.6-0.4-0.5-0.4-0.4
Pavlov. Cond. change in total contacts0.91.01.6-0.90.90.90.90.81.0-0.71.11.31.11.1
Pavlov. Cond. index score0.50.60.8-0.80.80.80.80.70.9-0.70.80.90.80.8
Pavlov. Cond. latency score0.81.01.2-1.01.01.01.00.91.1-0.91.11.11.11.1
Pavlov. Cond. lever contacts1.41.72.3-1.21.21.21.21.21.3-1.21.31.51.31.3
Pavlov. Cond. magazine entry number0.00.00.1-0.20.20.20.20.20.1-0.30.20.10.20.2
Pavlov. Cond. intertrial magazine entries1.11.31.5-1.11.11.11.21.21.1-1.21.21.01.21.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.60.60.60.60.50.7-0.40.60.80.60.6
Pavlov. Cond. response bias0.00.00.00.0-0.0-0.0-0.1-0.10.00.2-0.00.1-0.0-0.0
Pavlov. Cond. lever latency0.20.20.40.5-0.5-0.5-0.5-0.6-0.50.6-0.5-0.0-0.5-0.5
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3-0.3-0.3-0.3-0.20.3-0.3-0.1-0.3-0.3
Pavlov. Cond. change in total contacts0.00.10.2-0.20.20.20.30.40.2-0.40.2-0.10.20.2
Pavlov. Cond. index score0.00.00.1-0.10.10.10.20.20.1-0.20.0-0.20.00.0
Pavlov. Cond. latency score0.00.00.1-0.00.0-0.00.10.1-0.0-0.1-0.1-0.3-0.1-0.1
Pavlov. Cond. lever contacts0.20.30.5-0.60.60.50.60.70.5-0.70.50.10.50.5
Pavlov. Cond. magazine entry number0.10.10.2-0.40.40.40.30.30.3-0.30.40.20.40.4
Pavlov. Cond. intertrial magazine entries0.60.91.0-1.01.00.90.90.81.0-0.81.00.61.01.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.10.10.10.20.20.1-0.20.0-0.20.00.0
Pavlov. Cond. response bias0.00.00.1-0.10.10.10.20.30.1-0.30.1-0.20.10.1
Time in closed arm before self-admin3.24.14.52.1-2.1-2.1-2.1-2.1-2.12.1-2.1-2.0-1.8-1.8
Time in closed arm after self-admin1.01.11.51.1-1.1-1.1-1.0-1.0-1.11.1-1.2-0.8-1.1-1.1
Time in open arm before self-admin0.10.10.1-0.20.20.20.10.20.2-0.2-0.00.4-0.4-0.4
Time in open arm after self-admin4.34.75.7-2.22.22.22.22.22.1-2.12.42.12.12.1
Bone: periosteal estimation0.71.42.41.1-1.1-1.1-1.1-1.1-1.21.1-1.1-1.6-1.2-1.2
Bone: periosteal perimeter1.22.03.01.3-1.4-1.4-1.4-1.4-1.41.4-1.4-1.7-1.4-1.4
Bone: post-yield work0.60.91.61.1-1.0-1.0-0.9-0.9-0.90.9-0.8-1.2-0.9-0.9
Progressive ratio test 1 active lever presses0.30.40.5-0.60.60.60.60.50.5-0.60.70.30.70.7
Progressive ratio test 1 breakpoint0.30.40.5-0.60.60.60.60.50.5-0.60.70.20.70.7
Progressive ratio test 1 inactive lever presses0.10.10.30.4-0.4-0.4-0.4-0.4-0.40.4-0.3-0.5-0.3-0.3
Progressive ratio test 2 active lever presses0.30.30.70.6-0.6-0.6-0.6-0.6-0.70.5-0.4-0.9-0.4-0.4
Progressive ratio test 2 breakpoint0.20.20.50.4-0.4-0.4-0.4-0.5-0.50.4-0.3-0.7-0.3-0.3
Progressive ratio test 2 inactive lever presses0.50.91.1-1.01.01.00.90.90.9-0.91.00.71.01.0
Incentive Sensitization - Responses0.60.81.00.9-0.9-0.9-0.9-0.9-0.90.9-0.8-1.0-0.8-0.8
Incentive Sensitization - Breakpoint0.50.60.70.8-0.8-0.8-0.8-0.8-0.80.7-0.7-0.9-0.7-0.7
Sum of active levers in priming session hrs 5-60.30.30.6-0.50.50.50.40.40.5-0.40.80.60.60.6
Progressive ratio2.43.84.42.0-2.0-2.0-2.0-1.9-2.01.9-2.1-1.6-2.0-2.0
Food seeking constrained by brief footshock1.01.21.31.1-1.1-1.1-1.1-1.1-1.21.1-0.9-1.2-1.0-1.0
Seeking ratio, punishment vs. effort0.60.81.4-0.90.90.90.80.80.9-0.81.20.61.01.0
Retroperitoneal fat weight1.98.08.9-3.02.92.92.82.82.9-2.82.82.62.72.7
Reaction time number correct3.87.37.82.7-2.6-2.7-2.7-2.6-2.82.7-2.7-2.8-2.7-2.7
Reaction time mean minus median0.00.00.10.0-0.1-0.10.10.3-0.2-0.3-0.1-0.2-0.1-0.1
Reaction time mean minus median AUC0.41.01.31.0-1.1-1.1-0.9-0.7-1.10.7-1.1-1.1-1.1-1.1
Reaction time num false alarms1.82.64.1-1.51.61.51.51.51.6-1.51.72.01.61.6
Reaction time num false alarms AUC2.13.34.9-1.71.71.71.81.81.8-1.81.92.21.81.8
Reaction time trials correct on left3.87.37.82.7-2.6-2.7-2.7-2.6-2.82.7-2.7-2.8-2.7-2.7
Reaction time trials on left3.77.07.42.6-2.6-2.6-2.6-2.6-2.72.6-2.7-2.7-2.7-2.7
Reaction time mean0.00.10.10.2-0.3-0.3-0.10.1-0.3-0.1-0.4-0.3-0.3-0.3
Reaction time mean AUC0.30.50.80.7-0.8-0.8-0.6-0.5-0.80.4-0.9-0.7-0.8-0.8
Median of all reaction times0.10.10.20.3-0.4-0.4-0.2-0.1-0.40.1-0.5-0.3-0.4-0.4
Reaction time omissions0.00.00.1-0.1-0.0-0.00.10.20.0-0.30.0-0.20.10.1
Reaction time false alarm rate6.48.910.7-2.92.92.92.92.93.0-2.93.03.33.03.0
Reaction time premature initiation rate0.00.00.10.2-0.2-0.2-0.1-0.1-0.30.0-0.1-0.4-0.2-0.2
Reaction time premature initiations1.83.13.51.8-1.8-1.8-1.7-1.7-1.91.7-1.8-1.9-1.8-1.8
Std. dev. reaction times0.00.10.2-0.20.10.10.30.40.0-0.50.10.00.10.1
Reaction time trials completed3.77.07.42.6-2.6-2.6-2.6-2.6-2.72.6-2.7-2.7-2.7-2.7
Reaction time trials AUC3.05.76.12.4-2.3-2.4-2.4-2.3-2.52.4-2.4-2.5-2.4-2.4
Run reversals in cocaine runway, females0.00.00.1-0.20.20.20.20.20.2-0.20.10.20.00.0
Run reversals in cocaine runway, males0.30.30.30.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.5-0.5
Latency to leave start box in cocaine runway0.10.10.1-0.30.30.30.30.30.3-0.30.40.30.30.3
Latency to leave start box in cocaine runway, F1.01.11.21.0-1.0-1.0-1.1-1.0-1.11.0-1.1-0.9-1.1-1.1
Latency to leave start box in cocaine runway, M4.74.45.0-2.12.12.12.12.12.1-2.12.21.92.12.1
Std. dev. time between licks in bursts0.00.10.10.2-0.2-0.2-0.2-0.3-0.20.3-0.3-0.3-0.2-0.2
Total sessions with >9 infusions0.00.00.0-0.10.10.10.10.1-0.0-0.10.1-0.20.20.2
Short access day 1 total inactive lever presses2.43.23.5-1.81.81.81.81.81.7-1.81.91.61.81.8
Short access day 10 total inactive lever presses0.51.21.4-1.11.11.11.21.21.2-1.11.01.11.01.0
Short access day 1 total infusions0.10.10.2-0.40.40.40.40.30.3-0.40.40.10.40.4
Short access day 10 total infusions0.50.70.80.9-0.9-0.9-0.9-0.9-0.90.8-0.7-0.9-0.7-0.7
Short access total infusions0.00.00.1-0.00.00.00.0-0.0-0.1-0.10.1-0.20.20.2
Short access day 1 locomotion0.30.40.60.6-0.6-0.6-0.6-0.7-0.70.7-0.5-0.8-0.6-0.6
Short access day 10 total locomotion0.10.10.2-0.40.40.40.30.30.2-0.40.30.10.30.3
Short access total locomotion0.20.30.50.5-0.5-0.5-0.5-0.5-0.70.4-0.5-0.6-0.5-0.5
One hour access (0.3 mA shock)0.91.01.41.0-1.0-1.0-1.0-1.0-1.00.9-1.0-1.2-0.9-0.9
Compulsive drug intake0.20.30.60.5-0.5-0.5-0.5-0.4-0.50.5-0.8-0.5-0.7-0.7
One hour access (shock baseline)0.10.10.20.4-0.4-0.4-0.4-0.4-0.40.3-0.1-0.5-0.2-0.2
Social response proportion0.40.40.70.6-0.6-0.5-0.7-0.6-0.70.6-0.9-0.3-0.8-0.8
Social responses0.30.40.70.5-0.6-0.5-0.6-0.6-0.70.6-0.8-0.8-0.7-0.7
Social time0.10.20.80.5-0.4-0.4-0.4-0.3-0.40.4-0.4-0.9-0.4-0.4
Soleus weight0.51.41.8-1.21.11.11.21.11.1-1.11.21.31.21.2
Bone: stiffness0.20.40.80.6-0.6-0.6-0.6-0.6-0.60.6-0.6-0.9-0.5-0.5
Tibialis anterior weight0.41.41.6-1.21.11.21.21.11.1-1.11.21.21.21.2
Time to tail flick, vehicle, before self-admin0.60.60.80.7-0.7-0.7-0.8-0.8-0.90.9-0.8-0.5-0.8-0.8
Time to tail flick, vehicle, after self-admin0.10.10.20.4-0.4-0.4-0.3-0.3-0.40.4-0.20.1-0.2-0.2
Time to tail flick, test, before self-admin0.70.70.90.8-0.8-0.8-0.8-0.8-0.90.8-0.8-0.9-0.9-0.9
Time to tail flick, test, after self-admin1.01.12.21.0-1.0-1.0-1.0-1.1-1.11.2-0.8-1.5-0.6-0.6
Delta time to tail flick, vehicle, before/after SA0.50.50.6-0.60.60.60.70.80.6-0.70.70.70.80.8
Delta time to tail flick, test, before/after SA0.00.00.1-0.10.10.10.10.00.00.10.1-0.10.30.3
Tibia length3.28.79.4-3.03.02.92.92.82.9-2.83.13.03.13.1
Ambulatory time before self-admin0.60.91.11.1-1.1-1.1-1.0-1.0-0.90.9-0.9-0.9-0.9-0.9
Ambulatory time after self-admin0.00.00.20.1-0.1-0.10.00.0-0.0-0.10.1-0.50.20.2
Bone: tissue strength1.11.11.41.0-1.0-1.0-1.1-1.2-1.01.2-1.1-1.0-1.0-1.0
Total heroin consumption0.20.30.6-0.50.50.50.40.30.5-0.40.70.40.70.7
Bone: trabecular number6.110.010.83.3-3.3-3.3-3.2-3.3-3.13.3-3.1-2.8-3.1-3.1
Bone: trabecular spacing1.41.92.1-1.41.41.41.41.51.3-1.51.31.31.41.4
Bone: trabecular thickness4.75.86.22.4-2.4-2.4-2.5-2.5-2.32.5-2.4-2.5-2.4-2.4
Bone: trabecular tissue density1.01.51.9-1.31.41.41.21.21.2-1.21.20.71.21.2
Water consumed over 24 hours0.20.30.40.5-0.4-0.5-0.5-0.5-0.60.5-0.6-0.7-0.6-0.6
Number of responses in last shaping day1.51.62.71.2-1.2-1.2-1.3-1.3-1.31.3-1.2-1.6-1.1-1.1