LOC686030

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	intron excision ratio	chr9_55947068_55947205	0.13	0.09	9.4e-03	0.12	0.05	0.1	0.1	5.0e-04	1.9e-02	1.4e-03	1.6e-03
2	Brain	gene expression	LOC686030	0.07	0.05	2.1e-05	0.05	0.04	0.04	0.04	3.8e-05	9.9e-05	7.3e-05	8.3e-05
3	pVTA	gene expression	LOC686030	0.09	0.06	1.2e-03	0.03	0.05	0.03	0.03	1.9e-02	3.9e-03	1.6e-02	2.1e-02
4	NAcc	gene expression	LOC686030	0.09	0.05	3.4e-12	0.08	0.08	0.08	0.08	1.8e-09	6.6e-10	4.2e-09	2.1e-09
5	PL	gene expression	LOC686030	0.05	0.03	3.6e-05	0.02	0.03	0.04	0.03	3.0e-03	8.1e-04	7.4e-05	2.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	3.1	5.2	11.1	3.3	-3.1	1.8	1.5	0.3
Area under the delay curve	0.5	0.5	0.7	-0.9	0.5	-0.7	-0.7	0.7
BMI with tail	2.5	8.0	11.3	-3.2	3.4	-3.0	-2.7	1.2
BMI without tail	0.2	0.4	0.9	-0.7	0.3	0.4	0.5	-1.0
Body weight	1.2	4.9	5.9	2.3	-2.4	2.4	2.3	-1.3
Weight adjusted by age	0.2	0.3	0.8	0.9	-0.7	0.2	0.1	0.4
Bone surface	2.9	5.1	10.9	3.3	-3.0	1.9	1.6	0.2
Bone volume	3.3	5.6	13.6	3.7	-3.1	1.7	1.4	0.6
Breakpoint value in progressive ratio session	0.2	0.2	0.9	0.9	-0.3	0.1	0.1	0.3
Number of licking bursts	0.5	0.6	0.9	-0.1	0.7	-0.9	-0.9	0.8
Context. condit. distance diff. score	0.9	1.1	3.4	-1.9	1.1	-0.2	-0.0	-0.9
Locomotion velocity, session 1	1.9	2.1	3.7	-1.9	1.6	-1.4	-1.4	0.6
Locomotion distance, session 1	0.2	0.3	0.7	-0.9	0.7	-0.4	-0.4	-0.1
Locomotion velocity, session 2	1.9	2.3	3.6	-1.7	1.9	-1.5	-1.4	0.8
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	0.5	-0.2	-0.2	-0.1
Locomotion velocity, session 3	0.8	0.9	1.8	-0.0	-0.5	1.1	1.1	-1.4
Locomotion distance, session 3	0.1	0.1	0.2	-0.3	0.0	0.2	0.2	-0.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.8	-1.3	1.0	-0.1	0.0	-0.9
Stereotopy head waving duration, day 3	0.5	0.6	1.4	-0.7	0.2	0.6	0.7	-1.2
Locomotion velocity, session 7	2.8	3.0	4.6	-2.1	2.1	-1.7	-1.6	0.9
Locomotion distance, session 7	0.2	0.3	0.4	-0.5	0.6	-0.6	-0.6	0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.2
Stereotopy head waving duration, day 7	0.0	0.1	0.2	-0.4	0.0	0.1	0.1	-0.2
Locomotion velocity, session 8	2.4	2.8	3.5	-1.7	1.5	-1.9	-1.8	1.5
Locomotion distance, session 8	0.7	1.0	2.6	-1.6	1.2	-0.5	-0.4	-0.5
Degree of sensitization distance	0.4	0.4	1.0	0.3	0.2	-0.7	-0.7	1.0
Degree of sensitization stereotypy	0.2	0.2	0.6	0.3	-0.2	-0.4	-0.4	0.8
Conditioned locomotion	2.0	2.4	5.7	2.4	-1.8	1.2	1.1	-0.1
Cocaine response after cond. corrected	1.4	1.6	4.0	1.4	-0.9	-0.6	-0.8	2.0
Cocaine response after cond. not corrected	1.3	1.5	3.6	1.5	-1.0	-0.4	-0.6	1.9
Cocaine response before conditioning	0.2	0.2	0.5	-0.7	0.4	0.2	0.2	-0.5
Saline control response	0.3	0.4	0.9	-0.5	-0.0	0.5	0.6	-0.9
Bone: connectivity density	1.2	1.8	4.3	2.1	-1.8	0.9	0.7	0.5
Bone: cortical apparent density	3.3	4.4	6.4	-2.4	2.5	-2.3	-2.0	0.6
Bone: cortical area	0.2	0.2	0.6	0.8	-0.6	0.4	0.4	-0.0
Bone: cortical porosity	3.4	3.7	4.9	1.9	-2.0	2.2	2.1	-1.2
Bone: cortical porosity	4.5	4.9	6.1	2.4	-2.4	2.5	2.3	-1.1
Bone: cortical thickness	0.5	0.9	1.3	-1.1	1.2	-1.0	-0.9	0.2
Bone: cortical thickness	2.3	2.7	4.0	-1.0	1.5	-2.0	-1.9	1.6
Bone: cortical tissue density	3.4	4.5	6.6	-2.4	2.6	-2.3	-2.1	0.7
Condit. Reinf. active minus inactive responses	0.9	1.0	2.8	1.7	-0.1	-0.6	-0.6	1.2
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.2	1.1	0.5	-0.7	-0.9	1.0
Condit. Reinf. active responses	1.0	1.2	3.6	1.9	-0.7	-0.2	-0.3	1.3
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.5	-0.8	0.0	0.1	0.6
Incentive salience index mean	1.4	1.7	3.6	1.9	-0.1	-0.8	-1.0	1.8
Condit. Reinf. lever presses	0.4	0.6	1.8	1.3	-0.5	-0.1	-0.2	0.9
Condit. Reinf. active minus inactive responses	2.0	2.4	5.8	2.4	-1.9	0.3	0.2	1.6
Condit. Reinf. active-inactive response ratio	1.3	1.3	3.1	1.5	-0.6	-0.6	-0.7	1.8
Condit. Reinf. active responses	1.3	1.8	3.4	1.8	-1.5	-0.2	-0.2	1.8
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.2	0.6
Condit. Reinf. lever presses	1.9	2.6	5.3	0.0	0.6	-1.9	-1.9	2.3
Condit. Reinf. lever reinforcers received	1.4	2.0	4.5	1.9	-1.3	-0.5	-0.6	2.1
Conditioned reinforcement - actives	0.4	0.4	0.6	0.1	-0.3	0.7	0.8	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.1	0.3	-0.2	0.3	0.3	-0.2
Conditioned locomotion	0.0	0.1	0.1	-0.2	0.0	-0.3	-0.2	0.3
Patch foraging indifference point 0 sec	2.4	3.8	5.9	-0.5	1.6	-2.4	-2.4	2.2
Patch foraging indifference point AUC	0.0	0.0	0.1	0.3	-0.3	0.2	0.1	0.1
Delay disc. indifference point, 0s delay	1.5	1.6	2.3	-1.2	1.5	-1.5	-1.3	0.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	-0.6	0.4	-0.6	-0.6	0.6
Delay disc. indifference point, 2s delay	1.8	2.0	3.0	-0.4	0.9	-1.7	-1.7	1.7
Delay disc. indifference point, 24s delay	0.3	0.2	0.8	-0.9	0.5	-0.1	-0.0	-0.4
Delay disc. indifference point, 4s delay	1.2	1.2	2.5	-1.6	1.0	-1.1	-1.0	0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	0.0
Indifference point function ln k	1.7	2.4	3.6	-1.0	1.5	-1.9	-1.9	1.3
Indifference point function log k	1.7	2.4	3.6	-1.0	1.5	-1.9	-1.9	1.3
Patch foraging total patch changes 0 sec	2.3	3.7	5.6	-0.5	1.6	-2.4	-2.4	2.1
Patch foraging total patch changes 12 sec	0.9	1.2	2.0	0.5	0.5	-1.3	-1.3	1.4
Patch foraging total patch changes 18 sec	2.8	3.6	4.7	-1.5	2.2	-2.1	-2.2	1.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3	0.3
Patch foraging total patch changes 6 sec	1.1	1.7	2.6	-0.5	1.1	-1.6	-1.6	1.4
Patch foraging time to switch 0 sec	0.6	0.9	1.9	0.1	-0.3	1.1	1.1	-1.4
Patch foraging water rate 0 sec	0.1	0.1	0.4	0.1	-0.3	-0.2	-0.2	0.7
Patch foraging water rate 12 sec	2.0	3.1	5.3	-0.3	1.0	-2.1	-2.1	2.3
Patch foraging water rate 18 sec	0.3	0.4	1.0	0.5	-0.7	-0.3	-0.3	1.0
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.1	-0.3	0.4	0.5	-0.4
Patch foraging water rate 6 sec	0.1	0.2	0.5	-0.7	-0.3	-0.2	-0.1	0.5
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.3	1.0	-1.5	0.8	0.8	0.1
Distance traveled before self-admin	1.1	1.2	2.9	1.7	-1.5	0.8	0.7	0.2
Distance traveled after self-admin	0.2	0.2	0.3	-0.3	0.2	-0.6	-0.5	0.6
Extensor digitorum longus weight	1.0	3.8	10.9	-3.3	2.4	-0.8	-0.5	-1.2
Bone: elastic displacement	0.6	0.6	1.2	-0.0	0.1	-1.0	-1.0	1.1
Bone: elastic work	1.0	1.3	3.4	1.9	-1.5	0.5	0.4	0.5
Bone: endosteal estimation	2.8	6.1	14.1	3.8	-2.9	2.1	1.8	-0.0
Bone: endosteal perimeter	2.2	4.6	9.7	3.1	-2.6	2.0	1.7	-0.1
Epididymis fat weight	2.4	5.7	7.5	2.1	-2.6	2.7	2.6	-1.8
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	-1.1	0.6	0.2	0.3	-0.8
Delta time in open arm before/after self-admin	2.1	2.0	5.8	2.4	-1.7	0.8	0.5	0.7
Diff in mean of infusions in LGA sessions	0.4	0.4	0.9	0.9	-0.1	-0.4	-0.5	0.9
Delay discount exponential model param	0.4	0.4	0.6	0.7	-0.4	0.7	0.7	-0.7
Extinction: sum of active levers before priming	1.4	1.4	2.6	1.6	-1.5	1.0	1.0	-0.2
Active lever presses in extinction session 6	0.6	0.6	2.2	1.5	-0.8	0.3	0.3	0.2
Bone: final force	2.9	4.6	5.5	2.4	-2.2	2.3	2.3	-1.5
Bone: final moment	2.5	4.1	4.9	2.1	-2.0	2.2	2.2	-1.5
Food consumed during 24 hour testing period	0.4	0.5	0.7	0.8	-0.7	0.6	0.7	-0.5
Glucose	1.3	1.9	4.5	-0.2	-0.6	1.5	1.6	-2.1
Heart weight	0.4	0.5	1.4	0.4	0.1	-0.7	-0.7	1.2
Delay discount hyperbolic model param	0.6	0.7	0.9	1.0	-0.6	0.9	0.8	-0.7
Intermittent access intake day 1-15 change	0.2	0.2	0.6	-0.8	0.0	0.1	0.2	-0.3
Intermittent access intake escalation	0.1	0.1	0.6	-0.8	-0.0	0.1	0.2	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.3	-0.6	0.5	0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.1	0.5	-0.1	0.1	-0.5
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.0	-0.1
Intermitt. access escalation Index	2.5	2.3	3.3	0.8	-1.5	1.8	1.8	-1.4
Intermittent access day 1 total infusions	2.1	2.4	5.6	2.4	-1.7	1.3	1.3	-0.5
Intermittent access day 15 total infusions	1.6	1.8	2.4	1.4	-1.5	1.4	1.4	-0.8
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.5	1.1	-1.2	1.0	1.0	-0.5
Intermittent access total infusions	2.2	2.5	4.0	2.0	-1.8	1.5	1.5	-0.7
Intermittent access day 1 locomotion	0.2	0.2	0.8	0.9	-0.4	0.2	0.2	0.0
Intermittent access day 15 total locomotion	0.6	0.7	1.5	0.9	-1.2	0.8	0.8	-0.2
Intermittent access total locomotion	0.6	0.7	1.2	0.7	-1.1	0.8	0.8	-0.4
Intermittent access standard deviation	0.3	0.3	0.7	0.0	-0.5	0.6	0.6	-0.8
Left kidney weight	0.2	0.5	1.3	1.2	-0.9	0.4	0.3	0.2
Right kidney weight	0.1	0.4	1.5	1.2	-0.6	0.2	0.0	0.4
Cocaine induced anxiety	0.2	0.2	0.9	-1.0	0.1	-0.2	-0.2	0.5
Post-drug Anxiety	0.6	0.6	1.2	-0.9	0.3	-0.7	-0.7	1.1
Baseline Anxiety	0.1	0.1	0.3	0.5	-0.2	-0.0	-0.1	0.1
Tail length	9.9	30.1	38.4	5.5	-6.0	6.2	5.7	-3.5
Length with tail	9.1	33.3	44.4	6.0	-6.7	6.4	5.9	-3.1
Length without tail	0.9	2.0	3.7	1.6	-1.9	1.4	1.3	-0.2
Times rat made contact with spout	0.4	0.4	0.8	0.4	-0.3	0.8	0.7	-0.9
Lifetime Intake	1.6	1.8	2.6	1.6	-1.4	1.3	1.3	-0.9
Liver weight, left	0.3	0.5	1.5	0.3	-1.2	0.7	0.7	0.1
Liver weight, right	0.3	0.6	1.1	0.7	-1.1	0.8	0.7	-0.0
Locomotor activity	0.1	0.2	0.4	-0.4	-0.6	0.3	0.4	0.2
Locomotor testing distance	0.3	0.5	1.1	-0.5	0.1	-0.7	-0.6	1.0
Locomotor testing rearing	0.2	0.2	0.4	-0.1	-0.6	0.6	0.7	-0.1
Locomotion in novel chamber	0.7	0.9	1.2	-0.9	1.1	-1.1	-1.0	0.6
Locomotion in novel chamber post-restriction	0.7	0.8	1.6	-1.2	1.2	-0.7	-0.7	-0.1
Fecal boli incidents, locomotor time 1	0.4	0.4	1.4	0.5	-0.7	-0.1	-0.3	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.3	-0.2	0.2	0.3	-0.4
Time >=10cm from walls, locomotor time 1	3.3	3.4	6.2	-0.1	1.2	-2.1	-2.2	2.5
Bouts of movement, locomotor time 1	0.2	0.3	0.7	-0.0	0.1	-0.5	-0.6	0.8
Total resting periods, locomotor time 1	0.9	1.0	1.5	-0.4	0.8	-1.2	-1.2	1.1
Rest time, locomotor task time 1	0.0	0.0	0.1	0.3	0.2	0.0	-0.0	-0.2
Distance moved, locomotor task time 1	0.2	0.2	0.6	0.1	-0.0	-0.5	-0.5	0.8
Vertical activity count, locomotor time 1	0.4	0.5	1.8	-1.3	0.5	0.0	0.2	-0.6
Time >=10cm from walls, locomotor time 2	2.0	2.2	5.2	1.5	-0.1	-1.2	-1.4	2.3
Bouts of movement, locomotor time 2	1.9	2.0	3.1	-0.6	1.1	-1.8	-1.7	1.7
Total resting periods, locomotor time 2	2.0	2.1	3.2	-0.5	1.1	-1.8	-1.7	1.7
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.2	0.2	0.3	0.4	-0.7
Distance moved, locomotor task time 2	0.6	0.6	1.6	0.4	0.1	-0.8	-0.9	1.3
Vertical activity count, locomotor time 2	0.4	0.4	0.6	-0.5	0.6	-0.8	-0.7	0.5
Light reinforcement 1	0.1	0.1	0.2	-0.4	0.5	-0.4	-0.3	-0.3
Light reinforcement 2	0.6	0.8	2.5	1.6	-0.6	-0.3	-0.4	0.9
Bone: marrow area	2.6	5.7	13.3	3.6	-2.8	2.0	1.8	-0.0
Bone: maximum diameter	0.3	0.6	1.2	1.1	-1.0	0.5	0.5	0.3
Bone: maximum force	3.4	5.8	9.2	3.0	-2.6	2.5	2.3	-1.2
Bone: maximum moment	3.0	5.2	8.0	2.8	-2.4	2.4	2.2	-1.2
Mean time between licks in bursts	0.4	0.6	1.7	-0.7	0.2	0.6	0.7	-1.3
Mean num. licks in bursts	0.5	0.6	0.9	0.3	-0.6	1.0	0.9	-0.9
Cd content in liver	1.6	1.7	2.8	0.1	-0.8	1.6	1.6	-1.7
Co content in liver	0.4	0.4	0.9	-1.0	0.8	-0.0	0.0	-0.7
Cu content in liver	0.2	0.2	0.7	0.8	-0.3	-0.2	-0.2	0.6
Fe content in liver	1.5	1.9	3.9	2.0	-1.7	1.1	1.0	-0.0
K content in liver	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.2	0.2
Mg content in liver	0.1	0.1	0.3	0.4	-0.5	0.1	0.1	0.3
Mn content in liver	1.1	1.2	2.3	-1.4	1.5	-1.0	-0.9	0.1
Na content in liver	0.3	0.3	1.1	0.3	-0.4	-0.3	-0.3	1.1
Rb content in liver	0.6	0.7	2.5	-0.0	-0.4	-0.7	-0.7	1.6
Se content in liver	0.2	0.3	0.7	0.7	-0.8	0.1	0.2	0.2
Sr content in liver	2.6	2.4	4.2	0.3	-1.0	1.8	1.8	-2.0
Zn content in liver	0.1	0.1	0.3	0.2	-0.1	0.4	0.3	-0.5
Bone: minimum diameter	0.6	1.2	3.0	1.7	-1.1	0.9	0.8	-0.0
Time in familiar zone, hab. session 1	0.5	0.4	0.9	-1.0	0.1	0.4	0.5	-0.9
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.9	-0.0	-0.5	-0.5	0.8
Total zone transitions, hab. session 1	0.7	1.0	1.5	-0.5	0.9	-1.2	-1.2	1.1
Total locomotion distance, hab. session 1	0.7	1.0	1.9	1.3	-0.1	-0.7	-0.9	1.4
Locomotion velocity, hab. session 1	0.4	0.6	1.9	1.4	-0.7	0.1	0.0	0.6
Time in familiar zone, hab. session 2	0.6	0.6	1.0	-0.5	1.0	-0.9	-1.0	0.5
Time in novel zone, hab. session 2	0.6	0.6	0.8	0.6	-0.8	0.8	0.9	-0.5
Total zone transitions, hab. session 2	0.3	0.4	0.8	-0.3	-0.2	0.7	0.7	-0.9
Total locomotion distance, hab. session 2	1.1	1.4	1.8	1.4	-1.0	1.3	1.2	-1.0
Locomotion velocity, hab. session 2	1.3	1.7	2.3	1.2	-1.1	1.5	1.4	-1.2
Novel to familiar place preference ratio	3.2	3.3	10.9	3.3	-1.6	1.3	1.1	-0.1
Novelty place preference	3.1	3.2	9.9	3.1	-1.7	1.3	1.2	-0.2
Time in novel zone, NPP test	2.7	2.8	9.4	3.1	-1.5	1.1	1.0	-0.1
Total zone transitions, NPP test	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.2	0.0
Total locomotion distance, NPP test	0.2	0.3	0.8	0.9	0.0	-0.4	-0.4	0.5
Locomotion velocity, NPP test	0.1	0.1	0.6	0.8	0.0	-0.2	-0.2	0.2
Intraocular pressure	1.6	2.3	4.1	-1.7	2.0	-1.5	-1.4	0.3
Delta distance traveled before/after self-admin	0.4	0.4	0.9	-0.9	0.8	-0.6	-0.5	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.5	0.1	-0.2	-0.1	-0.1
Parametrial fat weight	0.0	0.0	0.1	0.1	0.0	0.2	0.1	-0.2
Pavlov. Cond. lever latency	0.8	1.0	2.1	-1.4	0.5	0.5	0.6	-1.4
Pavlov. Cond. magazine entry latency	0.8	1.1	2.7	1.0	-0.2	-0.9	-1.0	1.6
Pavlov. Cond. change in total contacts	2.3	2.5	5.1	1.1	0.5	-1.6	-1.7	2.3
Pavlov. Cond. index score	0.7	0.9	1.9	1.4	-0.5	-0.5	-0.6	1.4
Pavlov. Cond. latency score	0.9	1.1	2.2	1.5	-0.7	-0.4	-0.5	1.5
Pavlov. Cond. lever contacts	0.8	0.9	2.4	1.5	-0.6	-0.4	-0.5	1.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.4	-1.5	0.4	0.5	0.7	-1.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.5	1.0	-1.1	1.2	1.2	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.2	1.2	-0.2	-0.7	-0.8	1.5
Pavlov. Cond. response bias	0.6	0.7	2.0	1.4	-0.4	-0.3	-0.4	1.0
Pavlov. Cond. lever latency	2.0	2.6	3.9	0.4	-1.4	1.9	2.0	-1.9
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	-0.5	0.9	-0.5	-0.6	0.1
Pavlov. Cond. change in total contacts	2.4	3.2	5.8	0.3	1.2	-2.1	-2.2	2.4
Pavlov. Cond. index score	1.4	1.8	2.7	-0.0	1.1	-1.6	-1.6	1.6
Pavlov. Cond. latency score	1.1	1.3	2.0	0.1	0.9	-1.3	-1.4	1.4
Pavlov. Cond. lever contacts	2.2	2.9	5.4	0.0	1.1	-2.0	-2.1	2.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.8	0.1	0.2	0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	2.9	-0.1	1.1	-1.7	-1.7	1.7
Pavlov. Cond. response bias	1.2	1.6	3.3	0.3	0.7	-1.4	-1.5	1.8
Time in closed arm before self-admin	2.2	2.5	5.1	2.0	-2.3	1.4	1.2	0.1
Time in closed arm after self-admin	0.3	0.3	0.9	0.1	-0.3	-0.3	-0.4	1.0
Time in open arm before self-admin	1.3	1.4	3.3	-1.8	1.4	-0.4	-0.1	-1.3
Time in open arm after self-admin	0.6	0.7	2.1	1.5	-0.7	0.6	0.5	-0.1
Bone: periosteal estimation	1.9	3.9	8.9	3.0	-2.4	1.7	1.5	-0.1
Bone: periosteal perimeter	1.3	2.2	5.1	2.3	-1.8	1.2	1.1	0.0
Bone: post-yield work	1.9	2.6	3.2	1.7	-1.6	1.8	1.7	-1.1
Progressive ratio test 1 active lever presses	0.9	0.9	1.3	0.8	-0.8	1.1	1.1	-0.9
Progressive ratio test 1 breakpoint	0.8	0.9	1.1	0.9	-0.9	1.0	1.0	-0.7
Progressive ratio test 1 inactive lever presses	2.1	2.3	5.9	-0.3	-0.4	1.5	1.7	-2.4
Progressive ratio test 2 active lever presses	1.2	1.3	2.0	0.6	-1.0	1.4	1.4	-1.1
Progressive ratio test 2 breakpoint	0.5	0.6	0.9	0.4	-0.6	0.9	0.9	-0.8
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	0.5	-0.5	0.8	0.8	-0.8
Incentive Sensitization - Responses	0.9	0.9	1.4	0.4	-1.0	1.2	1.2	-0.7
Incentive Sensitization - Breakpoint	0.8	0.8	1.3	0.3	-0.9	1.1	1.1	-0.7
Sum of active levers in priming session hrs 5-6	1.1	1.1	3.0	1.7	-1.2	0.7	0.7	0.0
Progressive ratio	0.3	0.4	1.0	-0.6	1.0	-0.2	-0.2	-0.7
Food seeking constrained by brief footshock	0.1	0.2	0.3	-0.4	-0.1	0.4	0.4	-0.5
Seeking ratio, punishment vs. effort	0.5	0.6	1.4	0.3	-1.2	0.8	0.8	-0.0
Retroperitoneal fat weight	0.3	1.1	1.7	0.5	-1.3	1.2	1.3	-0.9
Reaction time number correct	0.5	0.7	1.0	-0.7	0.8	-1.0	-0.9	0.6
Reaction time mean minus median	3.0	4.0	4.7	2.0	-1.9	2.2	2.1	-1.8
Reaction time mean minus median AUC	1.5	1.9	2.8	1.7	-1.3	1.4	1.3	-1.1
Reaction time num false alarms	1.4	1.9	4.0	-1.8	2.0	-1.1	-1.0	-0.5
Reaction time num false alarms AUC	1.6	2.3	4.7	-2.0	2.2	-1.1	-1.0	-0.7
Reaction time trials correct on left	0.5	0.7	1.0	-0.7	0.8	-1.0	-0.9	0.6
Reaction time trials on left	0.4	0.5	0.8	-0.7	0.7	-0.9	-0.8	0.5
Reaction time mean	4.0	5.6	7.9	2.8	-2.4	2.5	2.4	-1.7
Reaction time mean AUC	4.1	5.6	7.2	2.7	-2.3	2.5	2.4	-1.8
Median of all reaction times	3.1	4.3	6.6	2.6	-2.1	2.1	2.0	-1.3
Reaction time omissions	1.6	2.3	2.7	1.4	-1.6	1.6	1.6	-1.3
Reaction time false alarm rate	0.7	1.0	2.2	-1.3	1.5	-0.5	-0.5	-0.8
Reaction time premature initiation rate	4.2	5.7	8.3	-0.9	1.9	-2.9	-2.9	2.7
Reaction time premature initiations	4.7	6.6	9.8	-1.3	2.1	-3.1	-3.1	2.7
Std. dev. reaction times	3.2	4.5	6.3	2.5	-2.3	2.2	2.1	-1.4
Reaction time trials completed	0.4	0.5	0.8	-0.7	0.7	-0.9	-0.8	0.5
Reaction time trials AUC	0.3	0.5	0.7	-0.7	0.7	-0.9	-0.8	0.4
Run reversals in cocaine runway, females	0.3	0.3	0.7	-0.9	0.4	0.3	0.3	-0.7
Run reversals in cocaine runway, males	1.1	1.1	2.1	0.4	0.5	-1.2	-1.2	1.4
Latency to leave start box in cocaine runway	3.5	3.8	6.5	-2.4	2.6	-1.9	-1.7	0.4
Latency to leave start box in cocaine runway, F	2.7	2.9	5.6	-2.4	2.3	-1.4	-1.3	-0.1
Latency to leave start box in cocaine runway, M	1.3	1.2	1.8	-0.8	1.3	-1.2	-1.2	0.8
Std. dev. time between licks in bursts	0.7	0.8	1.7	-1.1	1.3	-0.8	-0.7	-0.2
Total sessions with >9 infusions	0.3	0.3	1.0	-0.1	0.1	0.4	0.5	-1.0
Short access day 1 total inactive lever presses	0.3	0.4	1.2	1.1	-0.4	-0.3	-0.2	0.6
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.2	0.0	0.0	0.1	-0.2
Short access day 1 total infusions	0.4	0.5	0.6	0.8	-0.7	0.7	0.7	-0.6
Short access day 10 total infusions	1.7	1.9	5.6	2.4	-1.5	0.9	0.9	-0.3
Short access total infusions	0.4	0.5	1.3	1.1	-0.6	0.5	0.6	-0.5
Short access day 1 locomotion	0.3	0.3	0.8	0.1	-0.2	0.6	0.6	-0.9
Short access day 10 total locomotion	0.3	0.3	0.8	0.9	-0.1	-0.5	-0.5	0.6
Short access total locomotion	0.7	0.8	0.9	0.8	-0.8	0.9	1.0	-0.9
One hour access (0.3 mA shock)	0.8	0.9	2.2	1.5	-1.2	0.7	0.7	-0.3
Compulsive drug intake	0.1	0.1	0.2	-0.4	0.5	-0.3	-0.3	-0.1
One hour access (shock baseline)	1.7	2.0	3.7	1.9	-1.8	1.2	1.2	-0.1
Social response proportion	2.9	3.1	6.3	2.3	-2.5	1.5	1.4	0.3
Social responses	2.0	2.6	5.3	0.9	-2.3	1.8	1.9	-0.6
Social time	1.2	1.6	2.6	0.2	-1.6	1.5	1.6	-0.8
Soleus weight	0.0	0.1	0.3	0.6	-0.3	-0.0	-0.0	0.5
Bone: stiffness	4.1	6.5	8.5	2.4	-2.6	2.9	2.8	-1.9
Tibialis anterior weight	0.3	1.0	2.5	-1.6	1.3	-0.5	-0.4	-0.5
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.5	-1.2	0.7	0.2	0.2	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.3	0.2	0.2	0.1	-0.3
Time to tail flick, test, before self-admin	0.4	0.4	0.7	-0.3	0.8	-0.8	-0.8	0.3
Time to tail flick, test, after self-admin	0.5	0.5	1.3	-1.1	0.4	0.3	0.4	-0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	0.9	-0.3	0.2	0.2	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.5	0.2	0.2	0.3	-0.3
Tibia length	4.4	12.3	15.6	3.8	-3.8	4.0	3.6	-2.1
Ambulatory time before self-admin	0.4	0.4	1.1	1.1	-0.9	0.4	0.3	0.1
Ambulatory time after self-admin	0.4	0.4	0.8	-0.4	0.4	-0.9	-0.8	0.6
Bone: tissue strength	3.6	3.5	5.0	0.8	-1.5	2.2	2.2	-2.2
Total heroin consumption	0.2	0.2	0.9	1.0	-0.3	0.3	0.3	-0.1
Bone: trabecular number	1.9	2.9	5.3	2.3	-2.3	1.5	1.3	-0.0
Bone: trabecular spacing	0.8	1.0	1.8	-1.3	1.2	-0.9	-0.9	0.3
Bone: trabecular thickness	1.0	1.2	3.6	1.9	-1.4	0.4	0.3	0.7
Bone: trabecular tissue density	0.3	0.4	1.2	0.0	-0.1	0.7	0.7	-1.1
Water consumed over 24 hours	0.4	0.5	0.8	-0.1	0.9	-0.9	-0.9	0.5
Number of responses in last shaping day	1.0	1.0	2.3	-1.2	0.4	0.7	0.8	-1.5