Hub : Genes

LOC134486131

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression LOC134486131 0.03 0.03 1.2e-03 0.02 0.03 0.02 0.02 1.3e-03 6.3e-04 1.3e-03 1.2e-03
2 pVTA gene expression LOC134486131 0.05 0.05 5.4e-04 0.04 0.03 0.03 0.03 7.3e-04 9.7e-04 1.7e-03 1.6e-03
3 Adipose gene expression LOC134486131 0.14 0.13 2.5e-12 0.1 0.1 0.11 0.1 1.5e-11 3.0e-11 9.4e-12 1.2e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.71.21.5-1.2-1.2-0.8
Area under the delay curve0.10.20.20.40.40.3
BMI with tail0.00.10.10.4-0.1-0.0
BMI without tail0.10.20.3-0.3-0.3-0.6
Body weight0.31.42.8-0.8-0.8-1.7
Weight adjusted by age1.72.63.11.81.71.4
Bone surface0.40.80.9-1.0-0.8-0.9
Bone volume1.52.73.1-1.8-1.7-1.4
Breakpoint value in progressive ratio session1.51.82.01.31.31.4
Number of licking bursts0.10.10.2-0.3-0.0-0.5
Context. condit. distance diff. score1.41.72.9-1.7-1.4-0.5
Locomotion velocity, session 10.00.00.00.10.00.2
Locomotion distance, session 10.10.10.1-0.2-0.3-0.3
Locomotion velocity, session 20.00.00.10.20.20.2
Locomotion distance, session 20.50.71.2-0.7-0.6-1.1
Locomotion velocity, session 30.20.20.4-0.4-0.6-0.1
Locomotion distance, session 30.30.40.6-0.5-0.8-0.4
Stereotopy head waving bouts, day 30.10.10.2-0.1-0.20.5
Stereotopy head waving duration, day 30.20.20.4-0.6-0.50.2
Locomotion velocity, session 70.30.30.7-0.5-0.9-0.2
Locomotion distance, session 70.10.10.20.50.20.3
Stereotopy head waving bouts, day 70.10.10.2-0.00.10.5
Stereotopy head waving duration, day 70.00.00.1-0.00.10.3
Locomotion velocity, session 80.40.50.8-0.9-0.8-0.4
Locomotion distance, session 82.43.44.3-2.1-1.9-1.6
Degree of sensitization distance0.30.40.50.70.70.3
Degree of sensitization stereotypy0.10.10.10.10.20.3
Conditioned locomotion3.74.26.52.32.61.0
Cocaine response after cond. corrected1.82.22.91.71.61.1
Cocaine response after cond. not corrected0.60.70.91.01.00.6
Cocaine response before conditioning2.93.55.0-2.2-2.0-1.2
Saline control response0.81.01.2-0.9-1.1-1.0
Bone: connectivity density0.40.60.8-0.9-0.7-0.6
Bone: cortical apparent density0.00.00.10.00.2-0.2
Bone: cortical area0.00.10.1-0.3-0.10.2
Bone: cortical porosity0.30.30.70.40.40.8
Bone: cortical porosity0.50.50.80.60.70.9
Bone: cortical thickness0.10.10.30.10.10.5
Bone: cortical thickness4.55.37.62.32.71.8
Bone: cortical tissue density0.00.00.10.10.3-0.2
Condit. Reinf. active minus inactive responses0.91.01.3-1.2-0.9-0.9
Condit. Reinf. active-inactive response ratio1.92.12.9-1.5-1.0-1.7
Condit. Reinf. active responses0.30.30.5-0.7-0.4-0.6
Condit. Reinf. inactive responses0.30.40.40.60.60.5
Incentive salience index mean0.91.11.3-1.1-0.8-1.1
Condit. Reinf. lever presses0.70.91.6-0.9-0.7-1.3
Condit. Reinf. active minus inactive responses0.60.81.1-1.0-0.9-0.7
Condit. Reinf. active-inactive response ratio2.02.33.1-1.8-1.5-1.2
Condit. Reinf. active responses0.40.60.7-0.8-0.8-0.6
Condit. Reinf. inactive responses0.00.10.10.30.30.2
Condit. Reinf. lever presses0.50.71.1-0.9-1.0-0.5
Condit. Reinf. lever reinforcers received0.50.70.8-0.9-0.9-0.6
Conditioned reinforcement - actives2.13.64.7-2.2-2.0-1.5
Conditioned reinforcement - inactives5.27.610.2-3.2-3.2-1.6
Conditioned locomotion1.31.61.9-1.4-1.3-1.2
Patch foraging indifference point 0 sec0.10.10.20.40.20.4
Patch foraging indifference point AUC1.21.73.41.10.61.9
Delay disc. indifference point, 0s delay0.00.00.00.00.0-0.1
Delay disc. indifference point, 16s delay1.71.92.31.51.21.3
Delay disc. indifference point, 2s delay0.40.50.80.70.90.4
Delay disc. indifference point, 24s delay0.30.30.70.60.10.8
Delay disc. indifference point, 4s delay0.40.40.70.60.90.3
Delay disc. indifference point, 8s delay0.10.10.2-0.5-0.4-0.2
Indifference point function ln k0.91.53.6-0.9-0.2-1.9
Indifference point function log k0.91.53.6-0.9-0.2-1.9
Patch foraging total patch changes 0 sec0.00.10.20.3-0.00.4
Patch foraging total patch changes 12 sec0.40.51.1-0.4-1.00.5
Patch foraging total patch changes 18 sec0.60.92.00.70.31.4
Patch foraging total patch changes 24 sec1.22.04.51.20.42.1
Patch foraging total patch changes 6 sec0.40.51.30.4-0.41.1
Patch foraging time to switch 0 sec0.00.00.1-0.1-0.3-0.1
Patch foraging water rate 0 sec0.00.10.10.20.3-0.2
Patch foraging water rate 12 sec0.30.71.30.91.10.3
Patch foraging water rate 18 sec0.30.40.6-0.8-0.7-0.3
Patch foraging water rate 24 sec0.40.60.90.71.00.6
Patch foraging water rate 6 sec0.20.30.40.40.70.6
Seeking ratio, delayed vs. immediate footshock0.10.20.3-0.4-0.6-0.1
Distance traveled before self-admin0.10.10.3-0.10.2-0.6
Distance traveled after self-admin0.00.00.10.00.2-0.3
Extensor digitorum longus weight0.31.11.21.10.91.1
Bone: elastic displacement1.82.13.41.31.11.8
Bone: elastic work1.31.72.31.31.01.5
Bone: endosteal estimation0.20.51.00.71.00.1
Bone: endosteal perimeter0.30.61.1-0.7-0.3-1.0
Epididymis fat weight0.92.93.7-1.9-1.9-1.3
Delta time in closed arm before/after self-admin0.10.10.20.40.4-0.3
Delta time in open arm before/after self-admin0.20.10.3-0.60.0-0.4
Diff in mean of infusions in LGA sessions1.51.82.21.31.51.2
Delay discount exponential model param0.20.20.3-0.5-0.5-0.4
Extinction: sum of active levers before priming0.10.10.10.30.4-0.1
Active lever presses in extinction session 60.10.10.2-0.3-0.4-0.1
Bone: final force0.00.00.0-0.2-0.1-0.1
Bone: final moment0.00.00.00.0-0.00.2
Food consumed during 24 hour testing period4.86.78.5-2.9-2.9-1.7
Glucose2.03.13.8-1.9-1.9-1.4
Heart weight0.81.31.41.21.11.1
Delay discount hyperbolic model param0.30.30.4-0.5-0.6-0.4
Intermittent access intake day 1-15 change0.40.71.0-0.8-0.7-1.0
Intermittent access intake escalation0.51.01.2-1.0-0.9-1.1
Intermittent access intake escalation 21.71.92.2-1.4-1.2-1.5
Intermitt. access day 1 inactive lever presses0.00.00.10.0-0.1-0.3
Intermitt. access day 15 inactive lever presses0.51.01.1-1.0-0.8-1.1
Intermitt. access escalation Index0.00.00.1-0.0-0.30.2
Intermittent access day 1 total infusions2.74.45.0-2.2-1.9-2.1
Intermittent access day 15 total infusions3.24.85.7-2.4-2.1-2.1
Intermittent access terminal intake (last 3 days)3.24.24.9-2.2-1.9-2.1
Intermittent access total infusions3.84.55.7-2.4-1.8-2.2
Intermittent access day 1 locomotion1.92.42.7-1.7-1.4-1.6
Intermittent access day 15 total locomotion1.01.92.1-1.5-1.4-1.2
Intermittent access total locomotion1.82.22.5-1.6-1.2-1.6
Intermittent access standard deviation2.04.25.5-2.2-1.6-2.3
Left kidney weight0.73.34.3-1.8-1.6-2.1
Right kidney weight1.46.16.4-2.4-2.5-2.5
Cocaine induced anxiety0.10.10.20.40.20.4
Post-drug Anxiety1.82.02.11.51.31.4
Baseline Anxiety1.21.31.81.11.31.0
Tail length0.31.31.8-1.1-0.8-1.4
Length with tail0.52.43.3-1.5-1.2-1.8
Length without tail0.72.33.3-1.4-1.3-1.8
Times rat made contact with spout0.20.20.3-0.4-0.4-0.6
Lifetime Intake3.64.45.4-2.3-1.7-2.2
Liver weight, left1.11.82.3-1.4-1.5-1.1
Liver weight, right1.11.92.3-1.3-1.3-1.5
Locomotor activity0.00.10.10.0-0.30.3
Locomotor testing distance0.71.21.5-1.1-1.2-1.0
Locomotor testing rearing0.10.10.1-0.3-0.3-0.4
Locomotion in novel chamber1.11.41.9-1.3-0.8-1.4
Locomotion in novel chamber post-restriction0.81.31.31.21.11.1
Fecal boli incidents, locomotor time 16.08.711.23.23.42.2
Change in fecal boli incidents, locomotor task6.86.78.4-2.9-2.7-2.0
Time >=10cm from walls, locomotor time 10.20.30.50.40.30.7
Bouts of movement, locomotor time 11.11.32.51.01.60.5
Total resting periods, locomotor time 10.91.01.91.01.40.5
Rest time, locomotor task time 10.81.02.00.91.40.3
Distance moved, locomotor task time 11.52.22.5-1.6-1.5-1.4
Vertical activity count, locomotor time 10.00.10.1-0.4-0.3-0.3
Time >=10cm from walls, locomotor time 23.45.06.3-2.5-2.4-1.7
Bouts of movement, locomotor time 20.20.30.30.50.50.5
Total resting periods, locomotor time 20.10.20.20.40.40.5
Rest time, locomotor task time 21.72.23.51.51.90.9
Distance moved, locomotor task time 23.84.55.6-2.4-2.1-1.8
Vertical activity count, locomotor time 21.82.53.1-1.8-1.6-1.3
Light reinforcement 10.20.50.7-0.7-0.9-0.4
Light reinforcement 20.20.30.8-0.3-0.0-0.9
Bone: marrow area0.20.51.00.71.00.1
Bone: maximum diameter0.10.10.2-0.4-0.1-0.4
Bone: maximum force0.10.10.3-0.5-0.4-0.1
Bone: maximum moment0.00.00.1-0.1-0.10.3
Mean time between licks in bursts0.61.52.31.31.50.8
Mean num. licks in bursts0.00.10.2-0.2-0.4-0.1
Cd content in liver3.23.56.2-2.1-2.5-0.3
Co content in liver1.11.31.51.21.21.0
Cu content in liver1.41.73.11.41.80.2
Fe content in liver0.70.81.40.91.20.5
K content in liver2.52.43.41.81.80.8
Mg content in liver1.61.62.91.41.7-0.0
Mn content in liver1.31.52.21.31.50.6
Na content in liver0.00.00.0-0.1-0.00.2
Rb content in liver1.31.51.71.31.01.3
Se content in liver4.85.68.72.62.91.3
Sr content in liver0.30.30.50.50.7-0.1
Zn content in liver0.40.40.4-0.6-0.6-0.6
Bone: minimum diameter0.30.50.8-0.9-0.5-0.7
Time in familiar zone, hab. session 10.80.81.30.70.71.2
Time in novel zone, hab. session 11.31.32.4-0.9-0.8-1.5
Total zone transitions, hab. session 11.92.73.8-1.8-1.9-1.0
Total locomotion distance, hab. session 10.81.11.5-1.2-1.2-0.5
Locomotion velocity, hab. session 10.60.81.2-1.0-1.1-0.4
Time in familiar zone, hab. session 20.00.00.0-0.2-0.1-0.1
Time in novel zone, hab. session 20.00.00.10.00.0-0.3
Total zone transitions, hab. session 21.72.22.7-1.5-1.6-1.2
Total locomotion distance, hab. session 20.00.00.1-0.1-0.30.1
Locomotion velocity, hab. session 20.00.00.0-0.1-0.2-0.0
Novel to familiar place preference ratio1.11.21.6-1.1-1.3-0.9
Novelty place preference1.01.11.4-1.0-1.2-0.9
Time in novel zone, NPP test0.70.71.1-0.9-1.0-0.6
Total zone transitions, NPP test0.81.12.30.80.71.5
Total locomotion distance, NPP test0.60.81.60.70.61.3
Locomotion velocity, NPP test0.40.51.00.60.51.0
Intraocular pressure0.00.00.00.0-0.0-0.0
Delta distance traveled before/after self-admin0.20.30.40.60.40.5
Delta ambulatory time before/after self-admin0.10.10.10.30.4-0.0
Parametrial fat weight0.20.40.9-0.6-0.9-0.2
Pavlov. Cond. lever latency0.50.71.00.91.00.6
Pavlov. Cond. magazine entry latency0.91.21.6-1.1-1.2-0.9
Pavlov. Cond. change in total contacts0.10.10.10.30.2-0.3
Pavlov. Cond. index score0.60.71.0-0.8-1.0-0.7
Pavlov. Cond. latency score0.60.81.1-0.8-1.1-0.8
Pavlov. Cond. lever contacts0.50.60.7-0.8-0.8-0.7
Pavlov. Cond. magazine entry number1.11.42.01.21.40.8
Pavlov. Cond. intertrial magazine entries0.20.20.50.10.20.7
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-0.8-1.0-0.7
Pavlov. Cond. response bias1.01.21.9-1.2-1.4-0.6
Pavlov. Cond. lever latency1.72.33.41.61.80.9
Pavlov. Cond. magazine entry latency1.11.31.4-1.1-1.2-1.1
Pavlov. Cond. change in total contacts0.81.31.9-1.2-1.4-0.7
Pavlov. Cond. index score1.82.43.2-1.6-1.8-1.2
Pavlov. Cond. latency score2.33.03.7-1.8-1.9-1.4
Pavlov. Cond. lever contacts2.12.94.2-1.9-2.0-1.0
Pavlov. Cond. magazine entry number0.91.11.31.01.10.9
Pavlov. Cond. intertrial magazine entries0.20.30.40.50.50.6
Pavlov. Cond. lever-magazine prob. diff.1.41.92.4-1.5-1.5-1.1
Pavlov. Cond. response bias1.82.53.6-1.7-1.9-1.0
Time in closed arm before self-admin0.81.01.8-1.3-0.8-0.7
Time in closed arm after self-admin0.30.40.6-0.5-0.5-0.8
Time in open arm before self-admin2.83.04.42.11.61.4
Time in open arm after self-admin0.91.01.01.01.01.0
Bone: periosteal estimation0.10.20.30.30.60.3
Bone: periosteal perimeter0.81.41.9-1.4-1.1-1.0
Bone: post-yield work0.00.00.0-0.2-0.1-0.2
Progressive ratio test 1 active lever presses2.83.53.8-2.0-1.8-1.9
Progressive ratio test 1 breakpoint2.83.53.8-1.9-1.7-1.9
Progressive ratio test 1 inactive lever presses1.11.62.1-1.3-1.4-1.0
Progressive ratio test 2 active lever presses5.36.28.3-2.9-2.6-1.8
Progressive ratio test 2 breakpoint5.66.58.6-2.9-2.7-1.9
Progressive ratio test 2 inactive lever presses2.64.25.3-2.3-2.0-1.8
Incentive Sensitization - Responses3.75.37.2-2.7-2.7-1.2
Incentive Sensitization - Breakpoint3.85.06.8-2.6-2.6-1.2
Sum of active levers in priming session hrs 5-60.80.71.01.00.90.6
Progressive ratio0.30.50.6-0.8-0.5-0.7
Food seeking constrained by brief footshock0.81.01.3-1.0-1.1-0.8
Seeking ratio, punishment vs. effort0.10.10.20.3-0.00.4
Retroperitoneal fat weight9.741.348.1-6.9-6.6-5.7
Reaction time number correct0.30.51.40.2-0.21.2
Reaction time mean minus median0.30.91.5-0.9-1.2-0.6
Reaction time mean minus median AUC0.30.71.3-0.8-1.2-0.5
Reaction time num false alarms1.52.22.31.51.51.4
Reaction time num false alarms AUC2.13.33.71.91.91.7
Reaction time trials correct on left0.30.51.40.2-0.21.2
Reaction time trials on left0.30.51.50.3-0.21.2
Reaction time mean0.60.92.0-0.7-0.3-1.4
Reaction time mean AUC0.71.12.5-0.8-0.4-1.6
Median of all reaction times0.81.23.1-0.7-0.1-1.7
Reaction time omissions0.40.51.01.00.60.3
Reaction time false alarm rate2.23.04.11.92.01.2
Reaction time premature initiation rate0.40.51.20.60.01.1
Reaction time premature initiations0.51.02.50.6-0.21.6
Std. dev. reaction times0.10.20.3-0.4-0.4-0.6
Reaction time trials completed0.30.51.50.3-0.21.2
Reaction time trials AUC0.20.51.20.1-0.41.1
Run reversals in cocaine runway, females0.50.51.4-0.30.1-1.2
Run reversals in cocaine runway, males3.43.44.12.01.52.0
Latency to leave start box in cocaine runway0.10.10.10.40.1-0.2
Latency to leave start box in cocaine runway, F0.20.30.6-0.2-0.7-0.5
Latency to leave start box in cocaine runway, M0.60.50.80.80.90.4
Std. dev. time between licks in bursts0.50.61.00.91.00.4
Total sessions with >9 infusions2.02.43.2-1.6-1.2-1.8
Short access day 1 total inactive lever presses0.81.01.6-1.1-1.3-0.6
Short access day 10 total inactive lever presses0.10.30.7-0.4-0.80.3
Short access day 1 total infusions2.33.03.7-1.9-1.4-1.9
Short access day 10 total infusions3.03.85.0-1.9-1.7-2.2
Short access total infusions2.93.74.7-2.0-1.5-2.2
Short access day 1 locomotion2.32.94.7-1.5-1.2-2.2
Short access day 10 total locomotion2.03.74.6-2.1-1.8-1.8
Short access total locomotion3.13.74.6-2.0-1.6-2.1
One hour access (0.3 mA shock)5.05.87.0-2.7-2.1-2.4
Compulsive drug intake2.42.83.41.91.51.7
One hour access (shock baseline)5.68.610.4-3.2-2.7-2.9
Social response proportion4.04.65.22.32.31.8
Social responses0.00.00.1-0.3-0.3-0.1
Social time1.72.33.11.51.11.8
Soleus weight1.13.24.22.02.01.2
Bone: stiffness0.40.71.0-1.0-0.7-0.8
Tibialis anterior weight2.79.311.03.33.12.7
Time to tail flick, vehicle, before self-admin2.62.73.6-1.9-1.7-1.2
Time to tail flick, vehicle, after self-admin2.83.75.5-2.3-2.1-1.0
Time to tail flick, test, before self-admin1.01.11.6-1.3-0.9-0.9
Time to tail flick, test, after self-admin2.72.83.7-1.9-1.7-1.3
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.1-0.20.5
Delta time to tail flick, test, before/after SA0.00.00.0-0.2-0.2-0.2
Tibia length0.20.50.90.90.80.2
Ambulatory time before self-admin0.10.20.30.20.6-0.3
Ambulatory time after self-admin0.10.10.3-0.10.3-0.5
Bone: tissue strength0.10.10.1-0.1-0.20.3
Total heroin consumption1.11.32.51.11.60.3
Bone: trabecular number0.40.60.7-0.8-0.7-0.7
Bone: trabecular spacing0.50.71.1-0.6-0.7-1.0
Bone: trabecular thickness0.40.50.6-0.8-0.8-0.4
Bone: trabecular tissue density0.60.91.41.01.20.5
Water consumed over 24 hours0.40.51.1-0.6-0.3-1.0
Number of responses in last shaping day3.03.33.6-1.9-1.8-1.8