Hub : Genes

LOC134483957

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability LOC134483957 0.72 0.09 0.0e+00 0.4 0.42 0.42 0.41 1.7e-47 7.8e-51 1.2e-50 3.8e-49
2 Adipose gene expression LOC134483957 0.86 0.06 0.0e+00 0.53 0.54 0.53 0.53 1.1e-68 5.9e-71 7.7e-70 1.3e-69
3 OFC gene expression LOC134483957 0.61 0.12 1.1e-16 0.49 0.49 0.51 0.51 1.7e-13 1.8e-13 3.6e-14 3.5e-14
4 pVTA gene expression LOC134483957 0.48 0.13 0.0e+00 0.51 0.5 0.53 0.52 1.1e-46 5.6e-46 4.1e-49 1.3e-48
5 PL gene expression LOC134483957 0.65 0.1 0.0e+00 0.67 0.67 0.67 0.67 3.0e-98 7.4e-99 1.1e-98 7.0e-99
6 Liver gene expression LOC134483957 0.39 0.13 0.0e+00 0.32 0.31 0.32 0.32 5.1e-36 1.2e-34 2.2e-36 9.8e-37
7 NAcc gene expression LOC134483957 0.52 0.08 0.0e+00 0.69 0.7 0.71 0.71 3.5e-146 1.5e-148 3.7e-153 1.5e-153
8 IL gene expression LOC134483957 0.76 0.1 0.0e+00 0.52 0.54 0.51 0.53 1.6e-14 2.4e-15 3.4e-14 7.3e-15
9 BLA gene expression LOC134483957 0.65 0.12 0.0e+00 0.57 0.61 0.61 0.6 2.1e-36 4.9e-40 7.1e-40 1.3e-39
10 Eye gene expression LOC134483957 0.56 0.18 3.0e-05 0.17 0.09 0.1 0.1 1.5e-03 1.8e-02 1.4e-02 1.3e-02
11 IC gene expression LOC134483957 0.66 0.11 0.0e+00 0.47 0.43 0.39 0.43 1.1e-21 1.5e-19 1.0e-17 8.1e-20
12 LHb gene expression LOC134483957 0.67 0.14 0.0e+00 0.52 0.49 0.42 0.51 2.3e-14 2.9e-13 3.2e-11 4.0e-14
13 Brain gene expression LOC134483957 0.62 0.1 0.0e+00 0.59 0.59 0.59 0.59 2.4e-68 2.4e-67 2.1e-67 8.0e-68
14 Brain mRNA stability LOC134483957 0.14 0.07 9.0e-13 0.14 0.12 0.12 0.13 5.4e-13 2.4e-11 1.5e-11 6.9e-12
15 RMTg gene expression LOC134483957 0.27 0.16 3.5e-04 0.1 0.06 0.08 0.07 1.0e-03 1.3e-02 3.2e-03 6.0e-03
16 RMTg mRNA stability LOC134483957 0.2 0.12 1.8e-03 0.02 0.04 0.02 0.04 8.7e-02 4.0e-02 7.9e-02 3.3e-02
17 BLA mRNA stability LOC134483957 0.21 0.16 9.5e-05 0.07 0.05 0.05 0.04 8.9e-05 1.2e-03 1.4e-03 1.9e-03
18 NAcc mRNA stability LOC134483957 0.12 0.08 1.2e-09 0.06 0.06 0.08 0.06 2.8e-09 1.0e-09 6.4e-12 3.4e-09
19 PL mRNA stability LOC134483957 0.03 0.02 4.2e-04 0.02 0.03 0.05 0.02 1.7e-03 5.4e-04 3.4e-06 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.61.13.6-1.2-1.1-1.0-0.8-0.9-0.9-0.9-1.3-1.4-0.9-0.9-1.0-0.9-1.0-0.9-1.90.6-0.5-0.6
Area under the delay curve0.10.20.80.00.10.40.30.20.30.30.20.00.30.30.30.30.40.4-0.70.90.7-0.0
BMI with tail2.06.717.4-3.4-3.0-2.5-2.3-2.6-2.4-2.5-2.8-3.2-2.5-2.5-2.4-2.4-2.4-2.3-4.21.3-1.6-1.5
BMI without tail1.03.08.5-2.1-1.9-1.7-1.7-1.8-1.7-1.7-1.5-2.1-1.7-1.7-1.6-1.6-1.7-1.7-2.91.1-0.7-0.7
Body weight2.812.517.2-4.1-4.0-3.7-3.7-3.8-3.7-3.8-3.6-4.0-3.7-3.6-3.7-3.7-3.6-3.5-4.1-1.1-2.3-1.6
Weight adjusted by age1.52.22.9-1.3-1.4-1.7-1.6-1.6-1.6-1.6-1.5-1.4-1.5-1.7-1.4-1.5-1.7-1.7-1.2-1.1-1.6-1.0
Bone surface5.09.113.2-3.3-3.4-3.2-3.0-3.1-3.0-3.1-3.6-3.4-3.0-3.0-3.1-3.0-3.1-3.0-3.1-1.4-2.4-1.9
Bone volume1.83.35.4-2.1-2.1-1.9-1.7-1.8-1.7-1.8-2.3-2.1-1.8-1.7-1.8-1.8-1.8-1.7-2.0-0.4-1.6-1.2
Breakpoint value in progressive ratio session3.74.55.5-2.3-2.2-2.3-2.2-2.2-2.2-2.2-2.3-2.2-2.3-2.3-2.2-2.2-2.2-2.2-1.6-1.4-2.0-1.3
Number of licking bursts0.30.60.8-0.8-0.7-0.7-0.8-0.7-0.7-0.7-0.9-0.7-0.8-0.9-0.8-0.8-0.9-0.7-0.6-0.5-0.9-0.7
Context. condit. distance diff. score2.22.73.61.61.71.61.71.91.71.81.81.61.81.61.81.81.71.61.41.41.71.1
Locomotion velocity, session 10.00.00.20.10.10.2-0.00.1-0.10.10.40.10.0-0.00.00.00.10.20.1-0.20.40.2
Locomotion distance, session 10.50.72.5-1.0-1.0-0.7-0.7-0.7-0.8-0.7-0.7-1.1-0.8-0.8-0.8-0.8-0.6-0.6-1.60.6-0.1-0.2
Locomotion velocity, session 22.83.35.0-2.2-2.1-1.8-1.9-1.9-1.8-1.9-1.7-2.0-2.0-1.9-2.0-2.0-1.7-1.7-2.2-0.6-1.3-0.7
Locomotion distance, session 20.81.13.6-1.3-1.2-0.9-1.1-1.1-1.1-1.1-0.8-1.3-1.0-1.1-1.0-1.0-1.0-0.9-1.90.4-0.3-0.1
Locomotion velocity, session 30.10.11.00.20.20.30.40.40.30.40.40.20.30.30.30.30.30.3-0.21.00.40.3
Locomotion distance, session 30.00.00.00.10.10.10.10.1-0.10.10.10.10.10.00.10.10.10.1-0.20.10.10.0
Stereotopy head waving bouts, day 31.01.12.70.70.81.11.11.01.21.01.00.71.11.11.11.11.21.2-0.01.61.30.9
Stereotopy head waving duration, day 31.11.32.00.90.91.21.21.21.31.11.00.91.31.21.31.31.21.20.61.41.20.8
Locomotion velocity, session 70.30.33.30.00.30.30.40.50.30.50.50.20.50.50.50.50.20.3-0.41.80.30.2
Locomotion distance, session 70.10.11.1-0.2-0.00.0-0.1-0.0-0.1-0.00.3-0.20.10.00.10.1-0.1-0.0-0.91.00.50.3
Stereotopy head waving bouts, day 70.00.00.3-0.00.0-0.10.20.20.20.2-0.30.00.10.10.10.1-0.0-0.00.10.5-0.3-0.2
Stereotopy head waving duration, day 70.70.91.8-1.1-1.0-1.2-0.9-0.8-0.9-0.8-1.3-1.0-0.9-0.9-0.9-0.9-1.1-1.1-0.8-0.0-0.9-0.8
Locomotion velocity, session 80.91.11.5-0.8-1.0-1.1-1.2-1.1-1.2-1.1-0.9-1.1-1.1-1.2-1.1-1.1-1.1-1.1-1.0-1.1-0.4-0.1
Locomotion distance, session 80.30.41.40.20.40.60.60.70.50.70.70.40.70.60.60.60.70.60.11.20.80.6
Degree of sensitization distance0.10.10.8-0.3-0.2-0.1-0.1-0.10.0-0.10.0-0.30.0-0.0-0.0-0.0-0.2-0.1-0.70.90.30.1
Degree of sensitization stereotypy0.60.71.3-0.9-0.8-1.0-0.7-0.7-0.7-0.7-1.1-0.7-0.8-0.8-0.8-0.8-0.9-0.9-0.3-0.3-1.1-0.8
Conditioned locomotion1.61.82.6-1.4-1.4-1.5-1.6-1.4-1.6-1.5-1.1-1.3-1.4-1.5-1.4-1.4-1.5-1.5-1.2-1.1-0.8-0.7
Cocaine response after cond. corrected1.41.62.41.41.41.21.21.41.11.41.61.31.31.41.31.31.11.11.01.21.31.0
Cocaine response after cond. not corrected0.91.11.51.21.21.01.11.21.01.21.21.11.11.11.11.10.90.90.80.91.00.7
Cocaine response before conditioning0.91.11.9-1.0-1.1-1.0-0.9-1.1-0.8-1.1-1.4-1.0-1.1-1.1-1.0-1.0-0.9-0.9-0.7-0.9-1.3-0.9
Saline control response4.05.36.6-2.3-2.5-2.3-2.4-2.6-2.3-2.5-2.4-2.6-2.6-2.4-2.6-2.6-2.2-2.3-2.6-1.8-1.5-1.1
Bone: connectivity density2.84.37.4-2.3-2.3-2.2-2.0-2.1-2.1-2.1-2.5-2.5-2.1-2.0-2.1-2.1-2.1-2.1-2.7-0.5-1.3-1.3
Bone: cortical apparent density0.10.10.4-0.3-0.3-0.4-0.4-0.2-0.5-0.3-0.1-0.2-0.2-0.4-0.4-0.4-0.3-0.40.3-0.6-0.2-0.3
Bone: cortical area0.91.41.8-1.2-1.2-1.3-1.3-1.3-1.2-1.3-1.2-1.0-1.3-1.3-1.3-1.3-1.3-1.3-0.8-1.0-1.3-0.6
Bone: cortical porosity0.10.21.0-0.5-0.5-0.2-0.2-0.4-0.3-0.4-0.5-0.6-0.4-0.3-0.3-0.3-0.2-0.2-1.00.20.0-0.1
Bone: cortical porosity0.50.51.7-0.9-0.9-0.5-0.6-0.8-0.6-0.8-0.8-0.9-0.8-0.6-0.6-0.7-0.5-0.4-1.3-0.0-0.3-0.2
Bone: cortical thickness3.35.67.6-1.9-2.1-2.5-2.8-2.6-2.6-2.5-1.9-2.0-2.6-2.7-2.6-2.6-2.7-2.7-1.6-2.5-2.0-1.0
Bone: cortical thickness0.60.71.3-0.5-0.6-0.8-1.1-1.0-0.9-1.0-0.4-0.7-1.0-1.0-1.0-0.9-1.0-1.0-0.8-1.1-0.6-0.4
Bone: cortical tissue density0.20.20.6-0.4-0.4-0.5-0.6-0.4-0.7-0.4-0.3-0.4-0.4-0.6-0.5-0.5-0.5-0.60.2-0.8-0.3-0.3
Condit. Reinf. active minus inactive responses0.20.30.7-0.5-0.5-0.5-0.5-0.4-0.7-0.4-0.5-0.6-0.5-0.8-0.5-0.5-0.6-0.5-0.60.4-0.3-0.2
Condit. Reinf. active-inactive response ratio0.00.10.3-0.1-0.1-0.2-0.20.0-0.3-0.0-0.3-0.2-0.1-0.5-0.2-0.2-0.3-0.2-0.10.3-0.0-0.1
Condit. Reinf. active responses0.10.20.5-0.5-0.3-0.4-0.4-0.2-0.6-0.3-0.3-0.3-0.4-0.7-0.4-0.4-0.5-0.4-0.30.6-0.5-0.2
Condit. Reinf. inactive responses0.00.00.3-0.10.0-0.10.00.1-0.00.10.20.10.00.00.10.1-0.0-0.10.10.6-0.30.0
Incentive salience index mean0.40.50.9-0.9-0.8-0.7-0.7-0.5-0.8-0.6-0.6-0.8-0.7-0.9-0.7-0.7-0.8-0.7-0.80.6-0.4-0.2
Condit. Reinf. lever presses0.50.71.4-1.2-1.0-1.0-0.9-0.8-0.9-0.9-0.8-0.9-0.9-0.9-0.8-0.8-0.9-0.9-0.50.1-0.8-0.3
Condit. Reinf. active minus inactive responses0.00.10.20.10.10.30.30.10.30.2-0.40.00.10.10.10.10.30.40.40.0-0.30.0
Condit. Reinf. active-inactive response ratio0.50.61.70.60.70.91.00.81.00.80.30.80.70.80.70.71.01.11.30.6-0.20.2
Condit. Reinf. active responses0.20.21.0-0.5-0.6-0.3-0.2-0.5-0.3-0.4-1.0-0.7-0.5-0.4-0.5-0.4-0.4-0.2-0.7-0.0-0.4-0.2
Condit. Reinf. inactive responses0.70.93.9-0.9-0.9-0.9-0.8-0.9-0.9-0.9-1.0-1.2-0.9-0.8-0.8-0.8-1.0-0.9-2.0-0.1-0.1-0.3
Condit. Reinf. lever presses2.43.35.3-1.9-1.9-1.8-1.8-1.9-1.7-1.9-2.3-1.9-2.0-2.0-2.0-2.0-1.8-1.6-1.6-1.2-1.8-0.9
Condit. Reinf. lever reinforcers received0.40.61.7-0.8-0.9-0.6-0.6-0.8-0.5-0.8-1.3-1.0-0.8-0.7-0.8-0.8-0.6-0.5-0.9-0.4-0.7-0.3
Conditioned reinforcement - actives0.10.21.00.0-0.0-0.1-0.0-0.10.0-0.1-0.30.2-0.10.1-0.1-0.1-0.00.00.6-1.0-1.0-0.6
Conditioned reinforcement - inactives2.13.15.02.22.01.81.92.01.92.01.52.12.01.71.91.91.71.82.20.50.20.1
Conditioned locomotion7.69.912.63.53.43.43.43.33.43.33.23.53.33.43.33.33.33.33.31.51.71.2
Patch foraging indifference point 0 sec0.00.10.20.10.10.30.40.10.50.1-0.00.00.20.40.30.30.30.3-0.20.10.1-0.0
Patch foraging indifference point AUC2.43.44.1-2.0-2.0-1.9-2.0-2.0-2.0-2.0-2.0-1.8-1.9-1.8-2.0-2.0-1.9-1.8-1.0-1.9-1.7-1.2
Delay disc. indifference point, 0s delay0.90.93.10.50.71.00.90.91.00.91.00.61.00.91.00.91.01.0-0.51.51.80.6
Delay disc. indifference point, 16s delay0.60.61.00.60.70.91.00.80.90.80.60.80.90.80.90.81.01.00.51.00.30.1
Delay disc. indifference point, 2s delay0.10.20.40.30.40.60.50.50.50.40.30.30.30.40.30.40.50.6-0.10.60.4-0.0
Delay disc. indifference point, 24s delay0.10.10.50.30.30.30.30.20.30.30.60.30.40.30.40.30.40.2-0.20.20.70.2
Delay disc. indifference point, 4s delay0.30.31.10.30.40.50.50.40.50.50.50.20.40.40.40.50.50.5-0.70.91.00.2
Delay disc. indifference point, 8s delay0.20.21.10.20.20.40.20.30.30.30.40.00.40.30.40.40.30.4-0.60.71.00.2
Indifference point function ln k7.312.816.13.83.84.03.83.63.93.74.03.63.53.83.73.73.93.82.42.93.12.3
Indifference point function log k7.312.816.13.83.84.03.83.63.93.74.03.63.53.83.73.73.93.82.42.93.12.3
Patch foraging total patch changes 0 sec0.00.00.20.10.10.30.2-0.00.40.00.10.00.10.30.20.20.30.3-0.1-0.20.20.1
Patch foraging total patch changes 12 sec4.96.37.8-2.8-2.8-2.6-2.6-2.8-2.5-2.7-2.7-2.8-2.6-2.5-2.7-2.7-2.6-2.5-2.3-1.6-2.0-1.3
Patch foraging total patch changes 18 sec0.60.91.3-1.1-1.1-0.9-0.9-1.0-1.0-1.0-1.2-1.1-1.0-0.8-1.1-1.1-0.9-0.8-1.1-0.6-0.9-0.9
Patch foraging total patch changes 24 sec1.52.53.8-1.6-1.7-1.6-1.7-1.8-1.6-1.8-1.7-1.7-1.6-1.5-1.7-1.8-1.6-1.5-1.1-1.9-1.2-0.8
Patch foraging total patch changes 6 sec1.21.92.6-1.3-1.4-1.5-1.4-1.5-1.3-1.5-1.5-1.6-1.4-1.4-1.6-1.6-1.5-1.5-1.6-0.7-0.9-0.7
Patch foraging time to switch 0 sec1.63.45.1-2.3-2.0-2.2-1.8-1.7-1.9-1.7-2.1-2.1-1.6-2.0-1.6-1.6-2.1-2.1-2.00.4-1.5-1.2
Patch foraging water rate 0 sec3.57.310.33.23.03.02.72.72.92.73.03.12.62.82.72.72.72.83.20.32.11.6
Patch foraging water rate 12 sec7.215.021.24.64.34.23.93.94.24.04.44.23.94.03.84.04.04.03.41.43.52.5
Patch foraging water rate 18 sec3.14.86.82.62.52.52.32.32.42.32.52.32.22.12.02.02.32.31.71.22.01.6
Patch foraging water rate 24 sec5.37.49.73.13.02.92.72.92.82.83.13.03.02.82.82.82.72.72.90.72.51.6
Patch foraging water rate 6 sec4.76.910.33.23.03.12.62.62.82.73.12.92.52.52.52.52.82.92.20.72.51.8
Seeking ratio, delayed vs. immediate footshock0.10.10.80.20.20.20.30.30.20.30.10.10.40.20.40.30.10.1-0.50.9-0.0-0.4
Distance traveled before self-admin0.50.71.4-1.2-1.0-0.8-0.7-0.9-0.7-0.8-1.1-0.9-1.0-0.6-0.9-0.8-0.7-0.7-0.8-0.3-0.8-0.6
Distance traveled after self-admin0.20.30.5-0.7-0.7-0.6-0.5-0.7-0.5-0.6-0.7-0.6-0.6-0.3-0.5-0.5-0.5-0.50.1-0.6-0.6-0.1
Extensor digitorum longus weight7.830.837.8-6.1-6.0-6.1-6.2-6.0-6.1-6.0-5.4-5.7-5.9-5.9-5.9-5.9-5.9-6.0-4.7-3.3-4.2-2.5
Bone: elastic displacement0.80.92.01.41.30.90.70.90.90.91.41.20.80.80.90.90.80.71.3-0.30.90.6
Bone: elastic work0.91.11.8-0.9-0.9-1.0-1.3-1.3-1.1-1.2-0.6-0.9-1.3-1.3-1.2-1.2-1.1-1.1-0.7-1.3-0.5-0.3
Bone: endosteal estimation0.81.73.60.70.91.51.51.31.61.31.00.91.31.51.41.51.51.60.41.91.20.7
Bone: endosteal perimeter0.91.93.90.91.01.51.71.41.71.40.81.11.41.61.51.51.61.70.72.01.00.7
Epididymis fat weight3.612.215.53.43.53.83.93.73.93.73.33.73.63.93.73.73.83.83.72.22.31.8
Delta time in closed arm before/after self-admin0.20.20.9-0.2-0.2-0.5-0.6-0.3-0.5-0.30.1-0.5-0.4-0.4-0.4-0.5-0.6-0.6-0.90.00.40.1
Delta time in open arm before/after self-admin0.30.30.7-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.8-0.4-0.3-0.6-0.3-0.3-0.5-0.50.5-0.7-0.9-0.4
Diff in mean of infusions in LGA sessions0.70.91.5-0.8-0.8-1.1-1.0-0.9-1.1-0.9-1.0-0.9-1.0-1.1-1.2-1.0-1.1-1.1-0.4-0.9-0.9-0.3
Delay discount exponential model param0.10.10.50.0-0.0-0.3-0.2-0.1-0.2-0.2-0.20.0-0.2-0.2-0.2-0.2-0.3-0.30.7-0.7-0.60.1
Extinction: sum of active levers before priming3.03.34.5-2.1-2.0-1.9-1.7-1.9-1.7-1.9-2.0-2.0-2.0-1.9-2.0-1.8-1.8-1.8-1.9-0.7-1.7-1.2
Active lever presses in extinction session 63.53.54.5-2.0-2.0-2.1-2.0-1.9-2.0-2.0-2.1-1.8-2.0-1.9-1.9-1.8-2.0-2.0-0.9-1.8-1.8-1.2
Bone: final force2.43.84.9-2.2-2.2-2.0-2.1-2.1-2.0-2.1-2.0-2.1-2.0-2.1-2.2-2.1-1.9-1.8-1.8-1.4-1.5-0.9
Bone: final moment2.23.54.5-2.1-2.1-1.9-2.0-2.1-1.9-2.0-2.0-2.0-2.0-2.1-2.1-2.0-1.8-1.7-1.7-1.3-1.4-0.8
Food consumed during 24 hour testing period0.10.11.00.1-0.0-0.2-0.1-0.2-0.0-0.2-0.30.1-0.2-0.2-0.2-0.2-0.1-0.10.7-1.0-0.60.0
Glucose2.53.97.81.71.82.02.22.12.22.11.81.62.22.02.22.12.12.00.62.81.91.2
Heart weight1.32.07.91.01.21.31.41.41.31.41.30.81.51.41.41.41.31.2-0.52.82.10.9
Delay discount hyperbolic model param0.10.10.50.0-0.1-0.3-0.3-0.2-0.3-0.2-0.2-0.0-0.2-0.2-0.2-0.2-0.3-0.40.7-0.7-0.60.1
Intermittent access intake day 1-15 change0.81.74.21.51.41.21.31.41.31.41.11.51.41.31.41.31.31.22.10.10.20.2
Intermittent access intake escalation0.61.34.21.31.31.01.21.21.11.21.01.41.31.11.21.21.11.02.1-0.10.00.1
Intermittent access intake escalation 21.21.44.31.21.21.11.21.21.21.21.01.41.31.21.21.21.21.12.1-0.00.30.4
Intermitt. access day 1 inactive lever presses0.00.10.70.40.40.20.30.40.20.40.30.40.50.10.40.40.20.20.8-0.00.10.1
Intermitt. access day 15 inactive lever presses0.71.52.61.51.51.21.31.41.21.41.01.51.41.01.21.21.01.11.61.1-0.10.0
Intermitt. access escalation Index3.14.46.12.12.12.52.32.12.42.12.22.12.02.22.12.12.32.41.12.22.01.4
Intermittent access day 1 total infusions1.62.67.51.61.71.61.81.81.61.81.31.51.71.71.71.71.51.50.42.70.80.3
Intermittent access day 15 total infusions3.65.47.52.72.72.42.62.62.42.62.12.72.52.42.42.42.32.32.41.90.60.4
Intermittent access terminal intake (last 3 days)3.24.25.72.32.42.02.32.42.12.31.82.32.32.12.22.22.01.92.02.00.50.3
Intermittent access total infusions2.42.84.81.92.01.71.91.91.71.91.41.81.81.71.71.71.61.61.12.20.40.2
Intermittent access day 1 locomotion1.41.84.61.41.51.31.51.61.31.51.21.31.51.51.41.41.21.20.52.10.70.2
Intermittent access day 15 total locomotion2.34.25.72.42.42.02.42.42.22.31.72.32.22.22.12.12.12.02.11.80.2-0.1
Intermittent access total locomotion5.26.28.52.72.82.62.92.92.72.82.12.72.72.72.62.62.62.52.12.70.60.3
Intermittent access standard deviation0.81.62.91.61.61.21.31.51.21.41.31.51.51.21.31.31.11.11.70.30.70.3
Left kidney weight0.94.05.31.51.82.02.12.02.22.02.12.02.12.32.12.12.12.11.82.21.51.4
Right kidney weight0.52.22.91.31.41.61.51.41.61.51.61.61.61.61.51.51.61.61.70.91.01.2
Cocaine induced anxiety0.10.10.4-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.3-0.1-0.2-0.3-0.1-0.1-0.3-0.30.3-0.1-0.6-0.2
Post-drug Anxiety0.80.91.2-1.1-1.1-1.0-0.9-1.1-0.9-1.0-1.1-0.9-1.0-1.0-0.9-0.9-0.9-0.9-0.3-1.1-1.1-0.4
Baseline Anxiety0.30.30.9-0.5-0.6-0.4-0.5-0.7-0.4-0.7-0.5-0.6-0.6-0.4-0.6-0.7-0.4-0.4-0.6-0.90.10.2
Tail length0.31.22.0-1.0-1.1-1.2-1.4-1.4-1.3-1.3-0.7-1.0-1.3-1.1-1.2-1.2-1.1-1.2-0.5-1.4-0.30.1
Length with tail1.77.49.7-2.8-2.9-2.9-3.1-3.1-3.0-3.1-2.5-2.7-3.1-2.8-3.0-3.0-2.8-2.8-2.1-2.7-1.6-0.8
Length without tail1.86.07.5-2.3-2.5-2.4-2.7-2.7-2.6-2.7-2.3-2.5-2.7-2.6-2.7-2.7-2.4-2.4-2.1-2.7-1.5-0.9
Times rat made contact with spout0.50.51.8-0.8-0.8-0.6-0.7-0.8-0.7-0.7-0.7-0.9-0.8-0.7-0.8-0.8-0.6-0.6-1.4-0.2-0.4-0.5
Lifetime Intake1.62.03.91.71.71.41.61.61.41.61.21.51.51.51.41.41.31.30.72.00.50.2
Liver weight, left1.01.72.91.31.31.31.21.41.31.41.71.41.31.41.31.31.21.21.10.71.30.8
Liver weight, right2.34.16.12.32.22.12.02.22.02.22.52.02.22.02.12.12.01.91.01.52.11.2
Locomotor activity2.03.15.12.32.12.11.81.91.91.92.21.91.61.61.61.51.91.91.50.41.61.0
Locomotor testing distance2.34.16.72.62.42.42.02.02.12.12.52.21.82.11.81.82.22.21.40.52.11.2
Locomotor testing rearing1.83.66.02.52.22.12.02.02.02.02.21.91.82.01.81.82.02.01.00.82.11.1
Locomotion in novel chamber5.57.08.82.82.83.02.92.82.92.82.62.82.82.72.82.82.93.02.61.61.71.2
Locomotion in novel chamber post-restriction2.44.05.12.12.22.22.32.12.32.21.92.21.92.02.12.02.22.22.01.61.10.9
Fecal boli incidents, locomotor time 10.10.20.8-0.2-0.1-0.3-0.1-0.1-0.2-0.0-0.40.1-0.20.0-0.2-0.0-0.2-0.20.5-0.8-0.9-0.9
Change in fecal boli incidents, locomotor task0.10.10.40.00.00.30.10.00.20.00.2-0.20.20.10.20.10.30.3-0.60.60.60.3
Time >=10cm from walls, locomotor time 10.60.62.40.50.70.70.91.00.80.90.30.60.90.70.90.90.70.70.61.50.1-0.4
Bouts of movement, locomotor time 11.51.73.1-1.4-1.4-1.5-1.4-1.2-1.6-1.3-1.5-1.3-1.2-1.4-1.1-1.1-1.4-1.4-0.2-1.8-1.0-1.0
Total resting periods, locomotor time 11.11.21.8-1.2-1.2-1.2-1.1-1.0-1.3-1.0-1.4-1.1-1.0-1.1-0.9-0.9-1.1-1.1-0.2-1.3-1.0-1.0
Rest time, locomotor task time 11.51.93.41.51.51.51.51.41.51.51.31.61.31.51.31.41.51.51.80.20.90.6
Distance moved, locomotor task time 10.20.31.4-0.5-0.4-0.5-0.4-0.4-0.4-0.4-0.5-0.7-0.4-0.6-0.4-0.5-0.5-0.5-1.21.0-0.1-0.1
Vertical activity count, locomotor time 10.30.81.31.11.10.91.01.10.91.01.01.01.00.91.01.00.80.80.40.90.50.3
Time >=10cm from walls, locomotor time 20.00.00.1-0.3-0.2-0.0-0.0-0.00.0-0.1-0.3-0.10.1-0.10.1-0.00.10.10.3-0.1-0.1-0.3
Bouts of movement, locomotor time 20.50.81.2-1.0-1.0-1.0-0.9-0.9-1.1-0.9-0.9-0.9-0.7-0.8-0.6-0.7-1.0-1.0-0.8-0.7-0.7-0.8
Total resting periods, locomotor time 20.20.40.6-0.8-0.7-0.7-0.6-0.6-0.8-0.6-0.7-0.6-0.4-0.6-0.3-0.4-0.7-0.7-0.5-0.3-0.5-0.6
Rest time, locomotor task time 22.43.13.61.71.81.81.81.81.81.91.81.91.91.81.81.81.71.71.81.51.51.1
Distance moved, locomotor task time 21.21.52.0-1.1-1.2-1.3-1.4-1.3-1.3-1.3-1.3-1.3-1.2-1.4-1.3-1.4-1.3-1.3-1.0-1.0-0.8-0.6
Vertical activity count, locomotor time 20.10.11.30.40.3-0.0-0.20.0-0.1-0.00.30.20.0-0.20.0-0.1-0.1-0.10.4-1.1-0.1-0.0
Light reinforcement 10.10.20.50.50.40.50.50.30.50.30.40.40.30.70.20.30.50.50.10.10.30.2
Light reinforcement 20.60.91.41.01.01.11.21.01.11.00.71.20.91.10.91.01.11.21.20.3-0.00.0
Bone: marrow area0.91.94.20.70.91.51.61.41.61.41.11.01.41.61.51.51.61.70.42.01.40.8
Bone: maximum diameter0.10.30.6-0.6-0.6-0.5-0.4-0.5-0.4-0.5-0.8-0.4-0.5-0.4-0.4-0.4-0.5-0.40.2-0.7-0.8-0.2
Bone: maximum force3.46.08.5-2.9-2.8-2.5-2.5-2.6-2.4-2.6-2.8-2.7-2.6-2.6-2.7-2.6-2.4-2.3-2.4-0.9-2.0-1.2
Bone: maximum moment3.15.57.6-2.8-2.7-2.4-2.3-2.5-2.3-2.5-2.7-2.6-2.4-2.5-2.5-2.5-2.3-2.2-2.3-0.9-1.9-1.2
Mean time between licks in bursts0.10.30.9-0.3-0.4-0.4-0.6-0.5-0.5-0.5-0.2-0.6-0.5-0.5-0.6-0.5-0.5-0.5-1.0-0.70.20.1
Mean num. licks in bursts0.20.40.70.60.60.60.70.60.60.60.70.40.60.70.60.60.80.60.00.60.80.5
Cd content in liver1.21.32.01.11.21.31.41.21.31.20.91.21.11.21.11.21.41.31.40.60.0-0.1
Co content in liver1.72.03.71.61.61.61.21.31.31.31.91.61.41.31.41.41.41.51.50.11.51.1
Cu content in liver0.10.10.7-0.10.00.10.1-0.10.10.0-0.1-0.1-0.1-0.1-0.1-0.10.10.1-0.80.6-0.3-0.2
Fe content in liver0.10.20.6-0.2-0.3-0.4-0.4-0.5-0.4-0.5-0.3-0.3-0.5-0.3-0.5-0.4-0.5-0.4-0.3-0.8-0.3-0.4
K content in liver0.50.51.7-0.8-0.8-0.7-0.7-0.7-0.7-0.7-0.6-0.9-0.7-0.7-0.7-0.7-0.7-0.7-1.30.3-0.2-0.2
Mg content in liver0.40.41.00.50.60.70.60.60.60.60.60.40.60.50.60.60.60.6-0.41.00.80.3
Mn content in liver4.14.66.0-2.1-2.2-2.4-2.3-2.1-2.4-2.2-2.4-2.1-2.2-2.3-2.2-2.2-2.4-2.4-1.3-1.7-1.9-1.2
Na content in liver0.30.31.2-0.5-0.6-0.3-0.6-0.7-0.5-0.7-0.6-0.4-0.7-0.5-0.7-0.7-0.5-0.30.1-1.1-0.5-0.2
Rb content in liver1.92.23.01.61.61.71.71.51.71.61.51.41.51.61.51.51.71.60.41.41.50.7
Se content in liver0.10.10.10.40.30.20.30.30.30.3-0.10.30.20.20.20.20.30.20.30.1-0.3-0.1
Sr content in liver2.62.22.9-1.4-1.5-1.7-1.7-1.6-1.7-1.7-1.5-1.4-1.6-1.3-1.6-1.5-1.7-1.7-0.8-1.6-1.3-0.7
Zn content in liver0.20.30.9-0.6-0.5-0.4-0.5-0.6-0.4-0.6-0.4-0.6-0.5-0.6-0.5-0.5-0.4-0.4-1.00.0-0.3-0.2
Bone: minimum diameter0.61.14.70.50.71.11.31.01.21.00.60.61.01.11.11.11.11.2-0.12.20.80.4
Time in familiar zone, hab. session 10.20.21.00.30.40.50.50.40.50.40.30.30.30.40.30.30.40.50.31.00.10.2
Time in novel zone, hab. session 10.30.30.70.80.60.50.40.50.40.50.70.50.60.50.60.60.40.40.2-0.50.80.4
Total zone transitions, hab. session 10.81.11.5-1.2-1.2-0.9-1.1-1.1-1.1-1.1-1.0-1.1-1.1-1.2-1.1-1.1-0.9-0.9-1.1-0.1-1.0-0.5
Total locomotion distance, hab. session 10.40.51.60.20.40.70.70.70.70.70.70.60.70.70.80.80.80.80.71.30.70.5
Locomotion velocity, hab. session 10.10.10.7-0.3-0.10.20.20.10.20.10.20.10.20.20.20.20.30.30.30.80.20.2
Time in familiar zone, hab. session 20.00.00.10.40.3-0.0-0.10.0-0.2-0.00.30.00.0-0.10.00.0-0.1-0.2-0.2-0.30.40.1
Time in novel zone, hab. session 20.10.10.2-0.5-0.4-0.1-0.0-0.20.1-0.1-0.4-0.3-0.2-0.1-0.1-0.1-0.10.0-0.40.4-0.1-0.0
Total zone transitions, hab. session 21.41.85.1-1.8-1.7-1.1-1.1-1.3-1.2-1.3-1.6-1.9-1.3-1.3-1.3-1.3-1.0-0.9-2.30.7-0.6-0.6
Total locomotion distance, hab. session 20.20.22.6-0.4-0.20.20.30.20.20.20.0-0.30.20.20.20.20.40.4-0.81.60.70.2
Locomotion velocity, hab. session 20.20.33.0-0.3-0.00.40.50.40.40.30.2-0.10.40.40.40.40.50.6-0.51.70.60.2
Novel to familiar place preference ratio1.21.32.3-1.4-1.3-1.4-1.1-1.1-1.1-1.1-1.5-1.1-1.1-0.9-1.1-1.1-1.3-1.4-0.5-0.7-1.3-0.8
Novelty place preference0.60.61.3-1.0-0.9-1.0-0.6-0.7-0.7-0.7-1.1-0.7-0.7-0.5-0.7-0.7-0.9-0.9-0.3-0.3-1.0-0.6
Time in novel zone, NPP test0.40.40.9-0.8-0.7-0.9-0.5-0.6-0.6-0.6-0.9-0.6-0.6-0.4-0.6-0.6-0.7-0.8-0.2-0.3-0.8-0.5
Total zone transitions, NPP test2.02.94.9-2.2-2.1-1.6-1.7-1.9-1.7-1.9-1.9-2.1-1.8-1.8-1.8-1.8-1.5-1.3-2.0-0.4-1.2-0.7
Total locomotion distance, NPP test0.10.10.7-0.6-0.40.1-0.1-0.1-0.0-0.2-0.0-0.4-0.1-0.1-0.1-0.10.10.2-0.50.90.30.3
Locomotion velocity, NPP test0.10.10.6-0.7-0.5-0.0-0.2-0.3-0.1-0.3-0.1-0.5-0.3-0.2-0.2-0.20.00.1-0.50.70.00.2
Intraocular pressure0.91.46.31.31.30.60.91.30.91.21.01.51.41.11.41.40.60.52.5-0.50.20.1
Delta distance traveled before/after self-admin0.10.10.50.50.40.30.20.20.20.20.50.30.40.40.30.30.20.20.7-0.30.40.7
Delta ambulatory time before/after self-admin0.00.10.30.30.20.10.0-0.00.10.00.30.10.10.30.10.10.00.00.4-0.50.20.4
Parametrial fat weight3.68.611.62.72.92.93.13.23.03.12.93.03.33.23.43.32.72.82.73.02.31.6
Pavlov. Cond. lever latency0.20.30.60.80.70.50.50.60.50.60.50.60.60.50.50.50.50.40.7-0.20.30.2
Pavlov. Cond. magazine entry latency0.20.30.9-0.9-0.8-0.3-0.3-0.4-0.3-0.4-0.7-0.7-0.4-0.4-0.4-0.4-0.2-0.1-0.60.7-0.3-0.2
Pavlov. Cond. change in total contacts0.10.10.5-0.7-0.5-0.2-0.2-0.3-0.3-0.3-0.7-0.3-0.3-0.4-0.3-0.3-0.2-0.10.10.5-0.7-0.3
Pavlov. Cond. index score0.10.20.5-0.7-0.6-0.3-0.4-0.4-0.3-0.5-0.6-0.5-0.5-0.4-0.4-0.4-0.2-0.2-0.20.0-0.5-0.2
Pavlov. Cond. latency score0.10.10.4-0.6-0.5-0.1-0.2-0.3-0.2-0.3-0.4-0.4-0.3-0.2-0.3-0.3-0.1-0.0-0.30.3-0.2-0.0
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.4-0.1-0.2-0.3-0.1-0.3-0.3-0.4-0.3-0.2-0.2-0.2-0.1-0.1-0.50.5-0.00.1
Pavlov. Cond. magazine entry number0.20.30.60.80.70.40.50.60.50.60.80.50.60.60.60.60.40.30.10.40.70.4
Pavlov. Cond. intertrial magazine entries0.30.31.50.90.80.50.50.50.50.50.50.80.40.30.40.40.40.41.20.1-0.40.0
Pavlov. Cond. lever-magazine prob. diff.0.30.30.9-1.0-0.9-0.5-0.5-0.6-0.5-0.6-0.8-0.7-0.6-0.6-0.6-0.6-0.4-0.3-0.40.1-0.6-0.2
Pavlov. Cond. response bias0.20.20.4-0.7-0.6-0.3-0.4-0.5-0.4-0.5-0.6-0.4-0.5-0.5-0.5-0.5-0.3-0.3-0.0-0.2-0.6-0.3
Pavlov. Cond. lever latency0.70.91.41.01.01.01.01.00.91.01.10.81.01.11.01.01.00.90.40.91.20.4
Pavlov. Cond. magazine entry latency5.46.58.2-2.8-2.7-2.7-2.6-2.7-2.7-2.6-2.9-2.7-2.6-2.7-2.7-2.7-2.7-2.6-2.6-1.2-2.2-1.4
Pavlov. Cond. change in total contacts1.82.95.1-1.9-1.9-1.7-1.6-1.8-1.7-1.8-2.3-1.7-1.8-1.7-1.8-1.8-1.7-1.5-1.0-0.9-2.1-1.1
Pavlov. Cond. index score3.04.15.6-2.2-2.2-2.1-2.0-2.1-2.1-2.1-2.4-2.0-2.1-2.2-2.2-2.2-2.1-1.9-1.7-1.1-2.1-1.1
Pavlov. Cond. latency score2.73.54.7-2.1-2.0-1.9-1.9-2.0-1.9-1.9-2.2-1.9-2.0-2.0-2.0-2.0-1.9-1.8-1.4-1.0-2.0-1.1
Pavlov. Cond. lever contacts0.71.01.5-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.2-0.9-1.0-1.1-1.1-1.1-1.0-0.9-0.5-0.9-1.2-0.5
Pavlov. Cond. magazine entry number8.310.213.43.43.43.43.33.43.33.33.73.43.43.43.43.43.33.22.91.92.81.8
Pavlov. Cond. intertrial magazine entries1.11.72.21.31.31.51.41.31.41.31.31.41.41.41.41.41.51.51.40.70.80.5
Pavlov. Cond. lever-magazine prob. diff.3.74.96.7-2.4-2.4-2.3-2.3-2.3-2.3-2.3-2.6-2.3-2.3-2.4-2.4-2.4-2.3-2.1-1.9-1.2-2.2-1.2
Pavlov. Cond. response bias2.43.34.7-1.9-2.0-1.9-1.9-1.9-1.8-1.9-2.2-1.9-1.9-2.0-1.9-1.9-1.9-1.8-1.5-1.1-1.8-0.9
Time in closed arm before self-admin0.20.30.60.30.40.70.70.50.60.50.20.50.60.70.80.70.80.80.30.30.2-0.1
Time in closed arm after self-admin0.20.20.30.40.50.40.40.50.30.40.50.40.40.50.60.50.30.3-0.10.50.30.2
Time in open arm before self-admin0.40.42.00.70.70.50.30.60.40.51.10.40.40.40.20.30.30.3-0.30.81.40.9
Time in open arm after self-admin0.10.10.2-0.1-0.1-0.3-0.3-0.1-0.3-0.2-0.1-0.2-0.1-0.4-0.2-0.2-0.4-0.40.1-0.10.40.3
Bone: periosteal estimation0.00.00.2-0.4-0.20.00.1-0.10.1-0.0-0.2-0.1-0.00.10.00.10.00.1-0.10.4-0.20.0
Bone: periosteal perimeter0.10.20.6-0.6-0.6-0.4-0.3-0.5-0.3-0.5-0.8-0.5-0.5-0.4-0.4-0.4-0.4-0.3-0.50.1-0.4-0.1
Bone: post-yield work1.01.44.6-1.9-1.5-0.9-0.5-0.8-0.8-0.8-1.7-1.5-0.8-0.8-0.9-0.9-0.8-0.6-1.72.1-0.9-0.8
Progressive ratio test 1 active lever presses0.10.10.30.50.50.10.20.30.10.30.20.40.20.20.20.3-0.00.00.20.4-0.2-0.2
Progressive ratio test 1 breakpoint0.00.10.20.40.50.00.10.20.00.20.10.30.10.10.20.2-0.1-0.10.10.3-0.3-0.3
Progressive ratio test 1 inactive lever presses0.00.00.20.30.30.10.10.20.10.20.00.20.20.10.20.20.00.10.2-0.1-0.2-0.4
Progressive ratio test 2 active lever presses1.51.72.91.71.71.21.51.51.41.51.11.61.41.41.41.41.21.21.21.10.10.1
Progressive ratio test 2 breakpoint1.51.72.91.71.71.21.41.51.31.51.11.51.41.31.41.41.21.11.21.00.10.0
Progressive ratio test 2 inactive lever presses5.38.611.23.33.33.13.33.33.13.22.73.23.23.13.13.22.93.02.82.11.30.6
Incentive Sensitization - Responses0.10.10.4-0.1-0.0-0.2-0.0-0.0-0.1-0.1-0.4-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.50.5-0.7-0.4
Incentive Sensitization - Breakpoint0.00.10.40.10.2-0.00.20.20.10.2-0.20.10.10.10.10.10.00.0-0.30.6-0.5-0.3
Sum of active levers in priming session hrs 5-62.12.07.2-0.8-1.0-1.3-1.3-1.2-1.2-1.2-1.4-0.6-1.3-1.2-1.5-1.3-1.3-1.31.0-2.7-2.4-1.2
Progressive ratio0.81.33.2-1.5-1.3-1.1-0.9-0.9-1.0-1.0-1.4-1.5-1.0-1.1-0.9-0.9-1.0-1.0-1.81.1-0.5-0.9
Food seeking constrained by brief footshock0.10.10.2-0.2-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.1-0.5-0.3
Seeking ratio, punishment vs. effort1.11.63.01.71.51.41.11.21.31.21.71.51.21.31.11.11.31.31.4-0.31.01.0
Retroperitoneal fat weight10.143.051.06.86.97.17.16.97.16.96.76.86.86.96.96.96.96.95.65.15.33.8
Reaction time number correct0.10.30.8-0.4-0.5-0.4-0.6-0.7-0.4-0.6-0.4-0.3-0.8-0.5-0.7-0.7-0.5-0.4-0.2-0.9-0.30.0
Reaction time mean minus median2.15.27.2-2.5-2.4-2.6-2.4-2.3-2.7-2.3-2.6-2.3-2.2-2.5-2.1-2.1-2.5-2.5-1.3-1.7-2.2-1.7
Reaction time mean minus median AUC1.12.94.4-1.7-1.7-1.9-1.9-1.7-2.1-1.7-1.7-1.5-1.6-1.8-1.6-1.6-1.9-1.9-0.7-1.6-1.6-1.4
Reaction time num false alarms0.30.41.40.80.80.60.50.50.70.51.20.70.50.50.50.50.50.50.60.50.90.8
Reaction time num false alarms AUC0.00.10.30.10.1-0.1-0.3-0.1-0.1-0.20.50.0-0.1-0.3-0.2-0.2-0.3-0.3-0.00.20.40.4
Reaction time trials correct on left0.10.30.8-0.4-0.5-0.4-0.6-0.7-0.4-0.6-0.4-0.3-0.8-0.5-0.7-0.7-0.5-0.4-0.2-0.9-0.30.0
Reaction time trials on left0.20.41.1-0.5-0.6-0.6-0.7-0.8-0.5-0.7-0.5-0.4-0.9-0.6-0.8-0.8-0.6-0.5-0.2-1.0-0.4-0.0
Reaction time mean0.10.10.4-0.4-0.3-0.3-0.3-0.2-0.4-0.2-0.4-0.2-0.0-0.30.0-0.0-0.3-0.30.6-0.3-0.6-0.6
Reaction time mean AUC0.10.10.4-0.4-0.3-0.2-0.2-0.1-0.3-0.1-0.4-0.20.1-0.20.10.1-0.2-0.20.6-0.1-0.5-0.7
Median of all reaction times0.10.20.80.20.30.40.40.50.30.40.20.40.60.30.60.60.40.40.90.30.0-0.2
Reaction time omissions2.23.24.8-1.8-1.8-2.1-2.0-1.8-2.1-1.8-1.8-1.7-1.7-1.9-1.6-1.6-2.2-2.2-1.1-1.2-1.5-1.1
Reaction time false alarm rate0.20.30.90.60.70.40.30.50.30.41.00.50.60.20.50.50.20.10.30.70.70.5
Reaction time premature initiation rate2.12.93.8-1.6-1.7-1.8-1.9-1.9-1.9-1.9-1.5-2.0-1.9-1.7-1.8-1.9-1.7-1.8-1.7-1.6-0.5-0.7
Reaction time premature initiations2.74.86.9-2.0-2.2-2.2-2.4-2.5-2.3-2.4-2.0-2.3-2.6-2.2-2.5-2.5-2.2-2.2-1.9-2.4-1.0-0.8
Std. dev. reaction times0.91.62.4-1.4-1.4-1.5-1.4-1.2-1.6-1.2-1.4-1.2-1.0-1.4-0.9-1.0-1.5-1.4-0.3-1.1-1.2-1.2
Reaction time trials completed0.20.41.1-0.5-0.6-0.6-0.7-0.8-0.5-0.7-0.5-0.4-0.9-0.6-0.8-0.8-0.6-0.5-0.2-1.0-0.4-0.0
Reaction time trials AUC0.10.20.7-0.3-0.4-0.4-0.5-0.6-0.3-0.5-0.3-0.3-0.7-0.4-0.6-0.6-0.4-0.4-0.2-0.8-0.20.1
Run reversals in cocaine runway, females0.50.53.1-0.7-0.6-0.5-0.5-0.5-0.6-0.5-0.3-0.7-0.5-0.6-0.5-0.6-0.5-0.5-1.81.20.2-0.1
Run reversals in cocaine runway, males0.40.41.51.00.80.30.30.60.40.60.90.90.50.40.40.40.20.21.2-0.60.20.4
Latency to leave start box in cocaine runway0.10.10.8-0.10.00.10.20.20.10.2-0.1-0.10.20.10.20.10.10.1-0.20.9-0.1-0.1
Latency to leave start box in cocaine runway, F0.10.10.9-0.10.00.10.10.10.10.1-0.0-0.10.10.00.10.00.10.1-0.41.00.20.1
Latency to leave start box in cocaine runway, M0.10.10.4-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.2-0.3-0.2-0.3-0.4-0.4-0.0-0.2-0.6-0.3
Std. dev. time between licks in bursts0.10.10.70.40.40.20.00.20.30.20.80.20.20.20.20.30.10.1-0.0-0.20.80.5
Total sessions with >9 infusions0.10.10.8-0.1-0.1-0.2-0.1-0.1-0.2-0.2-0.3-0.3-0.3-0.2-0.3-0.2-0.3-0.2-0.80.9-0.3-0.4
Short access day 1 total inactive lever presses2.12.73.81.81.81.91.91.71.91.71.71.71.61.81.51.61.91.91.21.30.90.8
Short access day 10 total inactive lever presses0.20.40.70.80.80.60.50.70.50.80.80.70.80.50.70.60.40.50.50.60.60.4
Short access day 1 total infusions1.21.63.71.31.41.41.51.41.31.41.21.21.21.41.21.31.31.30.31.90.90.6
Short access day 10 total infusions0.30.44.50.30.40.20.50.40.30.4-0.00.10.20.30.10.20.10.1-0.92.1-0.4-0.5
Short access total infusions0.20.32.50.50.60.40.50.50.40.50.30.30.30.40.30.30.20.3-0.71.60.1-0.1
Short access day 1 locomotion0.91.12.41.41.41.01.21.31.01.31.01.11.21.01.01.00.90.90.41.50.30.1
Short access day 10 total locomotion0.50.92.61.01.10.91.11.20.91.10.81.01.01.00.90.90.80.80.51.60.2-0.1
Short access total locomotion0.91.12.91.21.31.11.21.31.11.20.91.11.11.10.91.01.01.00.51.70.3-0.0
One hour access (0.3 mA shock)5.86.79.33.13.02.52.73.02.62.92.62.83.02.52.82.82.42.32.32.01.80.9
Compulsive drug intake1.31.52.4-1.2-1.3-1.3-1.5-1.4-1.3-1.4-0.8-1.4-1.3-1.3-1.4-1.3-1.2-1.3-1.3-1.60.10.0
One hour access (shock baseline)4.97.410.03.13.22.83.03.12.83.02.53.13.02.83.02.92.62.72.82.31.20.7
Social response proportion0.80.91.5-1.0-1.0-0.9-0.8-0.9-0.9-0.9-1.2-1.1-0.8-1.0-0.8-0.9-0.8-0.8-0.8-1.0-0.9-1.0
Social responses0.30.31.0-0.3-0.5-0.6-0.6-0.6-0.6-0.5-0.6-0.5-0.5-0.6-0.6-0.6-0.6-0.6-0.5-1.0-0.5-0.6
Social time0.30.40.8-0.4-0.6-0.7-0.7-0.6-0.7-0.6-0.5-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.4-0.9-0.4-0.3
Soleus weight4.714.017.43.73.94.13.93.94.13.94.24.03.93.93.83.94.04.03.52.72.92.1
Bone: stiffness2.64.26.3-2.5-2.4-2.1-1.9-2.1-2.0-2.1-2.5-2.3-2.1-2.1-2.1-2.1-1.9-1.9-2.1-0.7-1.7-1.1
Tibialis anterior weight10.334.944.2-6.0-6.1-6.5-6.6-6.4-6.5-6.4-5.7-5.7-6.4-6.3-6.4-6.4-6.3-6.4-3.9-4.9-4.9-2.8
Time to tail flick, vehicle, before self-admin0.20.20.7-0.6-0.5-0.4-0.3-0.4-0.3-0.4-0.4-0.5-0.4-0.4-0.3-0.4-0.4-0.4-0.80.3-0.2-0.4
Time to tail flick, vehicle, after self-admin0.50.72.6-1.1-0.8-0.8-0.7-0.5-0.8-0.6-0.6-1.0-0.6-0.9-0.5-0.6-0.8-0.8-1.61.00.4-0.2
Time to tail flick, test, before self-admin1.81.94.31.31.51.41.41.71.31.51.51.11.71.31.41.21.21.20.12.11.50.5
Time to tail flick, test, after self-admin0.10.10.2-0.1-0.2-0.3-0.2-0.2-0.2-0.2-0.3-0.1-0.2-0.2-0.0-0.1-0.2-0.20.5-0.5-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.40.40.9-0.7-0.6-0.7-0.6-0.5-0.8-0.5-0.6-0.8-0.5-0.8-0.5-0.5-0.7-0.7-1.00.20.1-0.1
Delta time to tail flick, test, before/after SA1.91.96.6-1.1-1.3-1.5-1.5-1.5-1.4-1.4-1.3-0.9-1.5-1.3-1.2-1.1-1.4-1.40.7-2.6-1.4-0.6
Tibia length1.23.27.1-1.8-1.8-1.7-1.8-1.9-1.7-1.9-2.0-1.4-1.9-1.9-1.9-1.9-1.6-1.60.0-2.1-2.7-1.4
Ambulatory time before self-admin0.40.61.3-1.0-0.9-0.8-0.6-0.8-0.7-0.7-1.2-0.8-0.8-0.7-0.7-0.6-0.7-0.7-0.5-0.2-1.0-0.7
Ambulatory time after self-admin0.10.10.50.10.20.30.50.20.40.3-0.00.30.40.60.50.50.30.30.70.3-0.10.1
Bone: tissue strength0.00.00.0-0.1-0.1-0.1-0.0-0.0-0.0-0.1-0.2-0.2-0.0-0.2-0.1-0.1-0.0-0.0-0.10.2-0.1-0.0
Total heroin consumption5.46.37.9-2.8-2.7-2.7-2.6-2.6-2.6-2.7-2.7-2.7-2.7-2.5-2.8-2.7-2.6-2.6-2.0-2.0-1.9-1.2
Bone: trabecular number1.01.73.1-1.4-1.4-1.4-1.1-1.3-1.3-1.2-1.8-1.6-1.2-1.2-1.3-1.2-1.3-1.3-1.70.0-1.2-1.0
Bone: trabecular spacing0.50.71.50.90.90.90.80.90.90.91.20.90.80.80.80.80.90.80.60.50.90.7
Bone: trabecular thickness0.20.21.00.40.50.60.60.50.40.50.10.30.50.50.50.50.50.6-0.21.00.2-0.1
Bone: trabecular tissue density4.46.59.62.72.72.72.62.72.62.72.82.92.72.62.62.62.72.63.11.31.71.5
Water consumed over 24 hours1.01.31.8-1.0-1.1-1.2-1.2-1.3-1.1-1.2-1.2-1.2-1.2-1.2-1.3-1.2-1.1-1.1-1.4-1.0-0.7-0.6
Number of responses in last shaping day0.00.00.20.20.10.1-0.00.1-0.00.00.20.10.00.20.10.1-0.10.0-0.2-0.20.50.5