Hub : Genes

LOC134483869

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134483869	0.04	0.03	7.0e-05	0.03	0.02	0.02	0.03	5.0e-06	1.4e-04	1.1e-04	9.5e-06
2	Adipose	gene expression	LOC134483869	0.02	0.02	2.5e-03	0.02	0.02	0.02	0.02	3.7e-03	5.0e-03	4.6e-03	5.8e-03
3	OFC	gene expression	LOC134483869	0.5	0.28	1.3e-04	0.17	0.15	0.17	0.15	9.1e-05	2.6e-04	8.2e-05	2.3e-04
4	BLA	gene expression	LOC134483869	0.07	0.07	7.7e-03	0.04	0.03	0.02	0.03	3.3e-03	1.1e-02	2.4e-02	7.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.1	1.8	-1.0	1.0	1.4	0.8
Area under the delay curve	1.4	1.7	3.4	1.9	-1.3	-0.9	-1.0
BMI with tail	2.7	9.2	10.7	3.3	-3.0	-3.2	-2.6
BMI without tail	2.4	7.3	7.6	2.8	-2.7	-2.8	-2.6
Body weight	6.1	26.8	27.8	5.3	-5.1	-5.0	-5.3
Weight adjusted by age	1.3	1.9	4.2	1.4	-0.8	-2.1	-0.9
Bone surface	0.0	0.0	0.0	0.2	0.0	0.1	-0.1
Bone volume	0.0	0.0	0.1	0.2	-0.1	0.2	-0.3
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.2	0.2	0.1	-0.0
Number of licking bursts	0.3	0.5	0.7	-0.7	0.8	0.7	0.7
Context. condit. distance diff. score	0.1	0.2	0.5	-0.1	0.4	0.2	0.7
Locomotion velocity, session 1	0.8	0.8	1.1	-0.9	0.9	1.1	0.8
Locomotion distance, session 1	3.5	4.4	4.9	-2.2	2.0	2.1	2.1
Locomotion velocity, session 2	0.3	0.3	0.3	-0.4	0.6	0.6	0.6
Locomotion distance, session 2	0.9	1.3	1.8	-1.4	1.0	0.9	1.2
Locomotion velocity, session 3	0.3	0.3	0.7	0.4	-0.6	-0.1	-0.8
Locomotion distance, session 3	0.3	0.3	0.6	-0.6	0.3	0.8	0.5
Stereotopy head waving bouts, day 3	1.9	2.3	2.4	1.4	-1.5	-1.5	-1.6
Stereotopy head waving duration, day 3	0.3	0.3	0.6	0.6	-0.4	-0.8	-0.3
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	0.1	0.6	0.1
Locomotion distance, session 7	1.1	1.4	2.0	-1.4	1.0	1.4	0.9
Stereotopy head waving bouts, day 7	1.0	1.1	1.6	1.0	-1.1	-0.8	-1.2
Stereotopy head waving duration, day 7	1.0	1.2	1.7	1.0	-1.1	-0.9	-1.3
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1
Locomotion distance, session 8	0.7	1.0	1.5	-0.9	1.0	0.8	1.2
Degree of sensitization distance	0.0	0.0	0.1	-0.0	0.1	-0.2	0.1
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.1	0.1	0.3	-0.2
Conditioned locomotion	2.3	2.7	3.4	1.5	-1.6	-1.6	-1.8
Cocaine response after cond. corrected	1.4	1.7	2.9	1.5	-1.1	-1.7	-0.7
Cocaine response after cond. not corrected	1.3	1.6	2.4	1.5	-1.1	-1.6	-0.7
Cocaine response before conditioning	0.1	0.1	0.2	-0.3	0.0	0.5	-0.1
Saline control response	0.3	0.4	0.6	0.5	-0.7	-0.6	-0.8
Bone: connectivity density	0.5	0.7	1.2	-0.8	0.9	1.1	0.6
Bone: cortical apparent density	0.1	0.1	0.2	-0.3	0.2	0.5	0.1
Bone: cortical area	0.4	0.6	1.3	1.1	-0.7	-0.9	-0.2
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.0	-0.1	0.0
Bone: cortical porosity	0.0	0.0	0.0	0.1	-0.0	-0.2	0.1
Bone: cortical thickness	0.2	0.3	0.7	-0.1	0.6	0.4	0.8
Bone: cortical thickness	0.0	0.0	0.2	-0.4	-0.1	-0.0	0.0
Bone: cortical tissue density	0.0	0.1	0.2	-0.2	0.1	0.4	-0.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.4	-1.0	1.0	1.2	0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	0.1	0.3	0.3
Condit. Reinf. active responses	0.4	0.4	0.9	-0.7	0.6	0.9	0.3
Condit. Reinf. inactive responses	0.6	0.7	1.2	-0.9	0.8	1.1	0.3
Incentive salience index mean	0.3	0.4	0.6	-0.6	0.7	0.8	0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	0.1	0.1	0.0
Condit. Reinf. active minus inactive responses	0.7	1.0	1.1	-1.1	1.0	1.0	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.5	0.8	0.3	0.4
Condit. Reinf. active responses	0.8	1.1	1.3	-1.2	0.8	1.1	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	-0.5	0.3	-0.1
Condit. Reinf. lever presses	4.2	5.8	6.9	-2.6	2.0	2.5	2.5
Condit. Reinf. lever reinforcers received	1.4	2.0	2.4	-1.5	1.2	1.5	1.4
Conditioned reinforcement - actives	0.3	0.5	0.8	0.5	-0.9	-0.7	-0.7
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.5	0.2	0.2	0.1
Conditioned locomotion	1.2	1.6	1.9	1.1	-1.4	-1.2	-1.4
Patch foraging indifference point 0 sec	0.2	0.4	0.7	0.3	-0.8	-0.6	-0.6
Patch foraging indifference point AUC	0.2	0.4	0.8	-0.9	0.4	0.4	0.5
Delay disc. indifference point, 0s delay	0.5	0.6	1.0	1.0	-0.6	-1.0	-0.2
Delay disc. indifference point, 16s delay	0.5	0.6	1.7	1.3	-0.7	0.1	-0.6
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.1	0.2	-0.0	0.4
Delay disc. indifference point, 24s delay	2.9	3.2	5.8	2.4	-1.7	-1.4	-1.5
Delay disc. indifference point, 4s delay	1.8	1.9	2.7	1.7	-1.4	-1.3	-1.1
Delay disc. indifference point, 8s delay	1.8	2.2	2.8	1.7	-1.6	-1.1	-1.4
Indifference point function ln k	0.1	0.1	0.2	-0.2	0.4	0.3	0.3
Indifference point function log k	0.1	0.1	0.2	-0.2	0.4	0.3	0.3
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	0.2	-0.8	-0.6	-0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.6	-0.1	-0.2	0.2
Patch foraging total patch changes 18 sec	0.4	0.6	1.3	0.6	-1.1	-0.6	-0.7
Patch foraging total patch changes 24 sec	0.2	0.4	0.6	-0.8	0.4	0.4	0.7
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	0.1	-0.6	-0.4	-0.2
Patch foraging time to switch 0 sec	1.0	2.0	2.8	1.7	-1.5	-1.4	-1.1
Patch foraging water rate 0 sec	0.2	0.3	0.8	-0.9	0.6	0.1	0.4
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.7	0.4	0.4	0.3
Patch foraging water rate 18 sec	0.4	0.6	1.0	-0.9	0.7	1.0	0.5
Patch foraging water rate 24 sec	0.3	0.5	0.7	-0.9	0.6	0.6	0.6
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.4	0.4	0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.3	0.6	-0.0	1.1	-0.3
Distance traveled before self-admin	0.6	0.8	1.0	0.6	-0.9	-0.9	-1.0
Distance traveled after self-admin	0.1	0.1	0.3	0.3	-0.1	-0.2	-0.6
Extensor digitorum longus weight	0.3	1.0	1.1	-1.1	1.0	0.9	1.0
Bone: elastic displacement	0.0	0.0	0.0	0.0	0.1	0.1	0.2
Bone: elastic work	0.1	0.1	0.2	0.5	-0.4	-0.3	0.0
Bone: endosteal estimation	3.3	7.3	8.4	2.7	-2.9	-2.7	-2.6
Bone: endosteal perimeter	2.2	4.6	5.3	2.3	-2.1	-2.3	-1.8
Epididymis fat weight	0.8	2.6	3.2	1.7	-1.7	-1.8	-1.4
Delta time in closed arm before/after self-admin	3.2	3.0	5.2	1.6	-1.6	-2.3	-1.2
Delta time in open arm before/after self-admin	1.0	1.0	1.7	-1.0	0.8	1.3	0.7
Diff in mean of infusions in LGA sessions	0.3	0.4	0.6	-0.7	0.7	0.4	0.7
Delay discount exponential model param	1.3	1.4	3.0	-1.7	1.1	0.7	0.9
Extinction: sum of active levers before priming	0.2	0.3	0.6	-0.5	0.2	-0.8	0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.3	0.1	0.1
Bone: final force	4.1	6.6	7.3	2.7	-2.7	-2.5	-2.3
Bone: final moment	3.5	5.7	6.7	2.5	-2.6	-2.4	-2.0
Food consumed during 24 hour testing period	0.6	0.9	1.2	1.0	-0.9	-1.1	-0.7
Glucose	0.1	0.2	0.4	0.4	-0.0	-0.6	0.3
Heart weight	1.0	1.6	2.5	-1.1	1.6	0.5	1.5
Delay discount hyperbolic model param	0.9	0.9	2.2	-1.5	0.9	0.6	0.6
Intermittent access intake day 1-15 change	0.2	0.5	1.0	0.5	-0.9	-0.2	-1.0
Intermittent access intake escalation	0.3	0.6	1.1	0.5	-1.0	-0.0	-1.1
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.1	-0.1	0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.3	-1.5	1.3	0.4	1.2
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.9	0.4	-0.6	-0.2	-1.0
Intermitt. access escalation Index	0.4	0.6	0.7	-0.5	0.8	0.8	0.8
Intermittent access day 1 total infusions	0.4	0.6	0.9	-0.6	0.8	0.9	0.8
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.1	-0.2	0.6	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3
Intermittent access total infusions	0.1	0.2	0.5	-0.2	0.2	0.7	0.2
Intermittent access day 1 locomotion	0.1	0.2	0.2	0.4	-0.4	-0.2	-0.5
Intermittent access day 15 total locomotion	2.6	4.6	6.9	2.1	-2.2	-1.5	-2.6
Intermittent access total locomotion	0.9	1.1	1.7	1.1	-1.1	-0.4	-1.3
Intermittent access standard deviation	0.8	1.7	2.2	1.1	-1.5	-1.4	-1.3
Left kidney weight	3.2	14.8	16.0	3.8	-3.9	-3.6	-4.0
Right kidney weight	5.6	25.4	29.4	4.9	-5.4	-4.5	-5.3
Cocaine induced anxiety	0.2	0.2	0.4	-0.5	0.5	0.7	0.1
Post-drug Anxiety	0.4	0.4	0.7	-0.5	0.6	0.9	0.3
Baseline Anxiety	0.1	0.2	0.5	0.2	-0.1	-0.7	0.2
Tail length	0.8	3.3	5.2	1.5	-1.8	-1.5	-2.3
Length with tail	2.1	8.9	12.5	2.8	-2.9	-2.6	-3.5
Length without tail	3.1	10.1	10.5	3.2	-3.1	-3.2	-3.2
Times rat made contact with spout	3.8	4.3	5.7	-2.4	1.9	2.2	1.7
Lifetime Intake	0.0	0.0	0.0	0.2	-0.2	0.1	-0.1
Liver weight, left	1.9	3.1	3.9	1.7	-2.0	-1.7	-1.6
Liver weight, right	2.9	5.1	5.7	2.4	-2.3	-2.3	-2.1
Locomotor activity	0.1	0.1	0.3	0.2	-0.6	-0.2	-0.3
Locomotor testing distance	0.0	0.1	0.2	-0.0	-0.2	-0.5	0.1
Locomotor testing rearing	0.7	1.3	1.4	1.1	-1.2	-1.2	-1.1
Locomotion in novel chamber	0.2	0.3	0.7	-0.1	0.7	0.4	0.8
Locomotion in novel chamber post-restriction	1.6	2.7	2.8	1.7	-1.7	-1.6	-1.6
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.3	-0.3	0.1	-0.0
Change in fecal boli incidents, locomotor task	1.7	1.7	5.3	0.7	-0.7	-2.3	-0.6
Time >=10cm from walls, locomotor time 1	2.1	2.2	4.4	1.3	-1.2	-2.1	-1.2
Bouts of movement, locomotor time 1	0.4	0.4	0.9	-0.6	0.4	1.0	0.4
Total resting periods, locomotor time 1	0.1	0.2	0.5	-0.4	0.2	0.7	0.1
Rest time, locomotor task time 1	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.4
Vertical activity count, locomotor time 1	0.3	0.7	0.8	0.9	-0.8	-0.8	-0.8
Time >=10cm from walls, locomotor time 2	5.4	8.0	14.7	2.4	-2.5	-3.8	-2.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.1	0.2	0.4	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	0.0	-0.1	0.0
Distance moved, locomotor task time 2	2.1	2.5	3.4	1.1	-1.5	-1.8	-1.7
Vertical activity count, locomotor time 2	0.9	1.2	2.1	0.8	-1.0	-1.4	-1.1
Light reinforcement 1	1.4	3.5	4.4	1.8	-1.8	-2.1	-1.8
Light reinforcement 2	2.2	3.4	4.4	2.1	-1.9	-1.6	-1.7
Bone: marrow area	3.5	7.6	8.8	2.7	-3.0	-2.7	-2.6
Bone: maximum diameter	0.6	1.1	1.8	1.4	-0.9	-1.1	-0.6
Bone: maximum force	1.4	2.5	3.0	1.7	-1.7	-1.5	-1.3
Bone: maximum moment	1.1	1.9	2.4	1.5	-1.6	-1.4	-1.0
Mean time between licks in bursts	0.5	1.2	1.2	-1.1	1.1	1.1	1.0
Mean num. licks in bursts	0.3	0.5	0.8	-0.9	0.5	0.8	0.5
Cd content in liver	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3
Co content in liver	2.0	2.4	2.7	1.4	-1.5	-1.6	-1.6
Cu content in liver	3.1	3.7	4.2	-2.0	2.0	1.8	1.8
Fe content in liver	1.6	2.0	2.7	1.3	-1.4	-1.2	-1.7
K content in liver	0.9	0.8	1.1	-1.0	0.9	0.7	0.9
Mg content in liver	0.9	0.9	1.4	-0.9	1.1	0.6	1.2
Mn content in liver	0.0	0.0	0.1	0.0	0.0	-0.3	0.0
Na content in liver	0.3	0.4	0.6	-0.8	0.7	0.6	0.2
Rb content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.2
Se content in liver	1.5	1.8	2.1	-1.3	1.5	1.2	1.4
Sr content in liver	0.0	0.0	0.0	-0.1	0.2	0.1	0.1
Zn content in liver	0.3	0.3	1.0	-0.3	0.4	0.2	1.0
Bone: minimum diameter	2.1	3.8	5.5	2.4	-1.8	-2.2	-1.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.2	-0.0	0.3	0.1
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.4	-0.5	-0.7	-0.6
Total zone transitions, hab. session 1	3.2	4.5	5.6	-2.4	2.3	1.9	1.9
Total locomotion distance, hab. session 1	2.0	2.9	3.7	-1.9	1.8	1.5	1.6
Locomotion velocity, hab. session 1	1.9	2.7	3.4	-1.8	1.8	1.3	1.5
Time in familiar zone, hab. session 2	1.2	1.3	1.6	-1.1	1.1	1.1	1.3
Time in novel zone, hab. session 2	1.3	1.3	1.9	0.8	-1.4	-1.0	-1.3
Total zone transitions, hab. session 2	0.5	0.6	1.1	-1.1	0.7	0.5	0.7
Total locomotion distance, hab. session 2	2.5	3.3	4.6	-2.1	1.7	1.5	1.8
Locomotion velocity, hab. session 2	3.0	4.1	5.6	-2.4	1.9	1.7	2.0
Novel to familiar place preference ratio	0.4	0.5	1.0	0.6	-0.6	-1.0	-0.5
Novelty place preference	0.3	0.4	0.8	0.5	-0.5	-0.9	-0.5
Time in novel zone, NPP test	0.4	0.4	0.7	0.5	-0.6	-0.8	-0.6
Total zone transitions, NPP test	1.5	2.1	2.5	-1.6	1.4	1.3	1.6
Total locomotion distance, NPP test	1.3	1.8	2.3	-1.5	1.2	1.1	1.4
Locomotion velocity, NPP test	1.9	2.7	3.5	-1.9	1.6	1.3	1.8
Intraocular pressure	1.1	1.6	2.5	1.4	-1.6	-0.8	-1.2
Delta distance traveled before/after self-admin	0.4	0.4	0.7	-0.5	0.8	0.5	0.7
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	-0.5	0.9	0.6	0.5
Parametrial fat weight	2.8	6.6	9.8	2.2	-3.0	-1.8	-3.1
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.6	-0.8	-0.5	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.7	0.4	0.6	0.9
Pavlov. Cond. change in total contacts	0.5	0.5	0.6	0.7	-0.8	-0.6	-0.8
Pavlov. Cond. index score	0.1	0.1	0.3	-0.2	0.1	0.1	0.5
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.1	0.0	-0.1	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	0.4	0.1	0.3
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	0.9	-0.7	-0.8	-1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.1	0.4	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	0.1	0.1	0.4
Pavlov. Cond. response bias	0.7	0.9	1.0	-0.9	0.9	1.0	1.0
Pavlov. Cond. lever latency	2.3	3.1	4.2	2.0	-1.3	-2.0	-1.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.0	-0.5	-0.0	-0.4
Pavlov. Cond. change in total contacts	1.1	1.7	2.2	-1.5	1.0	1.5	1.2
Pavlov. Cond. index score	0.6	0.8	1.3	-1.2	0.5	1.1	0.7
Pavlov. Cond. latency score	0.4	0.6	0.9	-1.0	0.4	0.9	0.5
Pavlov. Cond. lever contacts	1.9	2.6	3.6	-1.9	1.2	1.9	1.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	0.3	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.9	1.1	-1.1	0.9	0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.0	-1.0	0.4	1.0	0.5
Pavlov. Cond. response bias	1.0	1.4	2.1	-1.4	0.7	1.5	0.9
Time in closed arm before self-admin	0.4	0.5	0.9	-0.6	0.9	0.3	0.9
Time in closed arm after self-admin	0.3	0.3	1.0	0.3	-0.1	-1.0	0.4
Time in open arm before self-admin	0.1	0.1	0.3	-0.4	0.3	0.5	0.1
Time in open arm after self-admin	1.2	1.4	3.0	-1.1	1.0	1.7	0.5
Bone: periosteal estimation	2.1	4.4	5.3	2.3	-2.2	-2.2	-1.7
Bone: periosteal perimeter	1.0	1.7	2.4	1.6	-1.3	-1.4	-0.9
Bone: post-yield work	0.3	0.4	0.6	0.8	-0.7	-0.6	-0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.0	-0.1	-0.5	0.1
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.1	0.1	-0.4	0.2
Progressive ratio test 1 inactive lever presses	0.3	0.5	0.7	0.5	-0.7	-0.6	-0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.2	0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.2	-0.1	0.1	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.5	0.2	0.4	0.1
Incentive Sensitization - Responses	0.8	1.1	1.5	-1.2	0.9	1.2	0.9
Incentive Sensitization - Breakpoint	0.5	0.7	1.1	-0.9	0.6	1.1	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	0.6	0.4	0.1
Progressive ratio	2.0	3.2	4.0	1.9	-1.9	-1.1	-2.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	0.1	0.3	0.5
Seeking ratio, punishment vs. effort	1.1	1.6	2.7	-1.2	1.4	0.6	1.7
Retroperitoneal fat weight	1.0	4.3	5.4	2.0	-2.3	-1.8	-2.1
Reaction time number correct	0.3	0.6	1.2	0.4	-0.9	-0.2	-1.1
Reaction time mean minus median	0.1	0.2	0.4	0.0	-0.4	0.4	-0.6
Reaction time mean minus median AUC	0.1	0.2	0.3	0.4	-0.6	0.2	-0.5
Reaction time num false alarms	0.5	0.7	1.8	-1.3	0.7	0.6	0.4
Reaction time num false alarms AUC	1.2	1.8	3.4	-1.8	1.3	1.0	1.0
Reaction time trials correct on left	0.3	0.6	1.2	0.4	-0.9	-0.2	-1.1
Reaction time trials on left	0.3	0.5	1.2	0.4	-0.9	-0.1	-1.1
Reaction time mean	0.2	0.3	0.5	0.5	-0.7	-0.4	-0.5
Reaction time mean AUC	0.4	0.7	1.1	0.8	-1.0	-0.5	-0.8
Median of all reaction times	0.3	0.4	0.6	0.7	-0.8	-0.7	-0.5
Reaction time omissions	0.0	0.1	0.1	0.2	-0.1	0.3	-0.3
Reaction time false alarm rate	1.7	2.3	3.1	-1.8	1.7	1.0	1.6
Reaction time premature initiation rate	0.1	0.2	0.4	-0.3	0.6	0.1	0.5
Reaction time premature initiations	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.3
Std. dev. reaction times	0.0	0.1	0.1	0.2	-0.2	0.4	-0.3
Reaction time trials completed	0.3	0.5	1.2	0.4	-0.9	-0.1	-1.1
Reaction time trials AUC	0.3	0.5	1.2	0.4	-0.9	-0.1	-1.1
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.3	-0.6	-0.0	-0.5
Run reversals in cocaine runway, males	0.5	0.5	1.1	0.2	-0.3	1.0	-0.9
Latency to leave start box in cocaine runway	0.5	0.6	1.1	-0.5	1.1	-0.6	0.9
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	-0.1	0.7	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.5	-0.5	0.1
Std. dev. time between licks in bursts	0.9	1.2	2.5	1.2	-0.9	-1.6	-0.2
Total sessions with >9 infusions	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.1	-0.2	0.0	-0.5
Short access day 10 total inactive lever presses	0.4	0.9	1.3	-1.1	0.9	1.0	0.6
Short access day 1 total infusions	0.2	0.3	0.6	-0.7	0.6	0.2	0.5
Short access day 10 total infusions	0.2	0.3	0.9	-0.3	0.3	1.0	0.2
Short access total infusions	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.0
Short access day 1 locomotion	0.1	0.1	0.2	-0.2	0.3	-0.3	0.4
Short access day 10 total locomotion	0.2	0.4	0.7	-0.8	0.4	-0.8	0.4
Short access total locomotion	0.2	0.2	0.7	-0.1	0.1	-0.8	0.2
One hour access (0.3 mA shock)	2.4	2.7	3.3	-1.8	1.6	1.6	1.6
Compulsive drug intake	1.8	2.1	3.3	-1.4	1.8	0.8	1.5
One hour access (shock baseline)	0.2	0.2	0.9	-0.2	-0.1	0.9	0.0
Social response proportion	0.1	0.1	0.2	0.3	-0.1	-0.4	0.1
Social responses	0.1	0.1	0.2	0.3	0.0	-0.4	0.3
Social time	0.2	0.3	0.3	-0.5	0.6	0.6	0.3
Soleus weight	0.6	1.8	3.0	1.6	-1.0	-1.7	-0.8
Bone: stiffness	1.1	1.8	2.2	1.4	-1.5	-1.2	-1.2
Tibialis anterior weight	0.6	1.9	2.3	-1.3	1.5	1.2	1.4
Time to tail flick, vehicle, before self-admin	1.8	1.8	3.0	1.4	-1.5	-0.4	-1.7
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.7	-0.6	0.8	0.5	0.8
Time to tail flick, test, before self-admin	0.5	0.5	1.0	-0.4	0.6	1.0	0.7
Time to tail flick, test, after self-admin	0.5	0.5	1.9	-0.4	0.1	1.4	0.1
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.1	-1.2	1.3	1.0	1.8
Delta time to tail flick, test, before/after SA	0.6	0.7	1.0	0.7	-1.0	-0.5	-1.0
Tibia length	2.4	6.6	8.7	2.5	-2.5	-2.3	-3.0
Ambulatory time before self-admin	0.1	0.1	0.1	0.1	-0.4	-0.3	-0.4
Ambulatory time after self-admin	0.1	0.1	0.2	-0.3	0.4	0.4	-0.1
Bone: tissue strength	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.0
Total heroin consumption	1.0	1.2	1.7	-1.1	1.2	1.3	0.5
Bone: trabecular number	1.0	1.6	2.3	-1.2	1.3	1.5	1.0
Bone: trabecular spacing	1.8	2.4	2.7	1.5	-1.5	-1.6	-1.5
Bone: trabecular thickness	0.2	0.3	0.5	0.5	-0.7	-0.1	-0.7
Bone: trabecular tissue density	0.0	0.1	0.1	-0.2	-0.0	0.4	-0.3
Water consumed over 24 hours	0.7	0.9	1.4	-0.7	1.1	0.7	1.2
Number of responses in last shaping day	0.5	0.5	1.4	-0.2	0.5	-1.2	0.7