Hub : Genes

LOC134481243

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC134481243	0.02	0.02	1.9e-03	0.01	0.01	0.01	0.01	4.8e-02	1.4e-02	3.0e-02	4.6e-02
2	Brain	gene expression	LOC134481243	0.14	0.07	1.3e-09	0.09	0.09	0.06	0.08	4.7e-09	1.7e-08	1.4e-06	5.4e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	3.2	6.0	7.6	-2.8	2.1
Area under the delay curve	0.7	1.1	1.2	1.0	-1.1
BMI with tail	1.4	5.0	7.1	-2.7	1.7
BMI without tail	2.3	12.4	14.9	-3.9	3.1
Body weight	14.7	64.5	77.0	-8.8	7.2
Weight adjusted by age	0.4	1.2	1.4	-1.2	1.0
Bone surface	3.8	7.5	9.7	-3.1	2.3
Bone volume	1.5	2.9	4.2	-2.1	1.3
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	0.0
Number of licking bursts	0.5	1.4	1.4	-1.2	1.2
Context. condit. distance diff. score	3.9	4.8	4.9	-2.2	2.2
Locomotion velocity, session 1	0.5	0.6	0.9	0.9	-0.6
Locomotion distance, session 1	1.9	2.5	3.4	1.9	-1.2
Locomotion velocity, session 2	0.2	0.3	0.3	0.6	-0.5
Locomotion distance, session 2	1.6	2.2	3.5	1.9	-0.9
Locomotion velocity, session 3	0.2	0.3	0.3	-0.6	0.5
Locomotion distance, session 3	0.0	0.1	0.1	-0.0	0.3
Stereotopy head waving bouts, day 3	2.5	3.0	3.5	-1.9	1.6
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.1	-0.3
Locomotion velocity, session 7	1.2	1.3	1.4	1.1	-1.2
Locomotion distance, session 7	0.3	0.4	0.6	0.8	-0.4
Stereotopy head waving bouts, day 7	0.2	0.3	0.3	0.6	-0.4
Stereotopy head waving duration, day 7	0.4	0.4	0.5	0.7	-0.6
Locomotion velocity, session 8	0.0	0.0	0.1	-0.3	0.1
Locomotion distance, session 8	0.8	1.1	1.2	-1.0	1.1
Degree of sensitization distance	1.4	1.5	1.7	1.3	-1.1
Degree of sensitization stereotypy	0.3	0.3	0.4	0.6	-0.6
Conditioned locomotion	0.0	0.0	0.0	0.0	-0.1
Cocaine response after cond. corrected	0.2	0.3	0.4	-0.6	-0.5
Cocaine response after cond. not corrected	0.1	0.2	0.3	-0.5	-0.3
Cocaine response before conditioning	0.1	0.1	0.3	0.1	0.5
Saline control response	4.2	5.8	6.7	-2.2	2.6
Bone: connectivity density	6.5	10.4	12.4	-3.5	2.9
Bone: cortical apparent density	0.4	0.6	0.8	0.5	-0.9
Bone: cortical area	1.2	2.0	2.4	-1.5	1.3
Bone: cortical porosity	0.1	0.1	0.1	-0.1	0.4
Bone: cortical porosity	0.1	0.2	0.3	0.5	-0.1
Bone: cortical thickness	1.5	2.4	3.0	-1.7	1.4
Bone: cortical thickness	2.1	2.5	2.7	-1.6	1.5
Bone: cortical tissue density	0.4	0.6	0.9	0.6	-0.9
Condit. Reinf. active minus inactive responses	0.8	0.9	0.9	1.0	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	-0.6
Condit. Reinf. active responses	0.5	0.6	1.0	1.0	-0.4
Condit. Reinf. inactive responses	0.7	0.9	1.6	1.3	-0.4
Incentive salience index mean	0.6	0.7	1.0	1.0	-0.7
Condit. Reinf. lever presses	0.6	0.9	1.3	1.1	-0.7
Condit. Reinf. active minus inactive responses	0.8	1.2	1.3	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.2	-0.5	0.5
Condit. Reinf. active responses	1.0	1.4	1.6	-1.1	1.3
Condit. Reinf. inactive responses	0.3	0.5	0.7	-0.6	0.8
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.1
Condit. Reinf. lever reinforcers received	0.4	0.5	0.7	-0.6	0.8
Conditioned reinforcement - actives	1.5	5.8	6.2	-2.3	2.5
Conditioned reinforcement - inactives	0.2	0.6	0.9	-0.6	1.0
Conditioned locomotion	3.1	4.6	5.0	-2.0	2.2
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.1	-0.1
Patch foraging indifference point AUC	0.9	2.2	2.2	-1.5	1.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.5	-0.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.4	0.6	-0.5
Delay disc. indifference point, 2s delay	2.8	3.1	3.7	1.6	-1.9
Delay disc. indifference point, 24s delay	0.6	0.9	0.9	1.0	-0.9
Delay disc. indifference point, 4s delay	1.0	1.1	1.4	0.9	-1.2
Delay disc. indifference point, 8s delay	0.2	0.3	0.4	0.7	-0.5
Indifference point function ln k	0.0	0.1	0.2	0.2	0.4
Indifference point function log k	0.0	0.1	0.2	0.2	0.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	0.0
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.7	0.4
Patch foraging total patch changes 18 sec	0.1	0.2	0.2	-0.5	0.5
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	-0.2	0.7
Patch foraging total patch changes 6 sec	0.2	0.4	0.4	-0.6	0.6
Patch foraging time to switch 0 sec	1.1	4.2	6.8	1.3	-2.6
Patch foraging water rate 0 sec	1.5	5.8	7.9	-1.9	2.8
Patch foraging water rate 12 sec	0.2	0.8	1.2	-0.6	1.1
Patch foraging water rate 18 sec	0.0	0.1	0.1	0.3	0.3
Patch foraging water rate 24 sec	3.1	4.4	5.4	-1.8	2.3
Patch foraging water rate 6 sec	0.8	1.2	1.7	-0.8	1.3
Seeking ratio, delayed vs. immediate footshock	1.4	2.1	2.2	1.5	-1.4
Distance traveled before self-admin	0.4	0.9	1.0	0.9	-1.0
Distance traveled after self-admin	0.1	0.1	0.2	0.5	-0.0
Extensor digitorum longus weight	5.8	23.2	25.0	-5.0	4.6
Bone: elastic displacement	0.3	0.3	0.5	-0.5	0.7
Bone: elastic work	4.4	5.7	5.8	-2.4	2.4
Bone: endosteal estimation	0.7	1.7	2.0	-1.2	1.4
Bone: endosteal perimeter	0.5	1.1	1.7	-0.8	1.3
Epididymis fat weight	0.0	0.0	0.0	0.2	-0.0
Delta time in closed arm before/after self-admin	0.3	0.2	0.3	-0.5	0.5
Delta time in open arm before/after self-admin	4.4	5.2	5.5	2.3	-2.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.3	0.4
Delay discount exponential model param	1.3	1.7	1.7	-1.3	1.3
Extinction: sum of active levers before priming	0.3	0.5	0.5	0.7	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	0.2
Bone: final force	2.1	3.4	4.0	-2.0	1.7
Bone: final moment	1.6	2.6	2.9	-1.7	1.5
Food consumed during 24 hour testing period	0.3	0.5	0.6	-0.8	0.6
Glucose	2.5	4.0	4.4	1.9	-2.1
Heart weight	0.4	0.6	1.0	-0.5	1.0
Delay discount hyperbolic model param	1.2	1.5	1.6	-1.2	1.3
Intermittent access intake day 1-15 change	0.4	2.0	2.2	-1.3	1.5
Intermittent access intake escalation	0.3	1.8	2.0	-1.3	1.4
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.0	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.6	-0.5	0.8
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.7	0.1	-0.8
Intermitt. access escalation Index	0.0	0.1	0.2	0.5	-0.2
Intermittent access day 1 total infusions	0.1	0.4	0.7	0.9	-0.4
Intermittent access day 15 total infusions	0.1	0.2	0.4	-0.1	0.6
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.1	0.2
Intermittent access total infusions	0.1	0.1	0.1	0.3	-0.2
Intermittent access day 1 locomotion	0.4	0.7	0.9	0.9	-0.7
Intermittent access day 15 total locomotion	0.2	0.7	1.1	-0.5	1.1
Intermittent access total locomotion	0.1	0.1	0.2	0.5	-0.1
Intermittent access standard deviation	0.0	0.2	0.3	-0.6	0.0
Left kidney weight	6.5	52.3	57.5	-7.6	6.9
Right kidney weight	5.9	41.5	47.1	-6.9	6.0
Cocaine induced anxiety	0.0	0.1	0.1	0.3	-0.4
Post-drug Anxiety	4.2	4.8	6.5	1.7	-2.6
Baseline Anxiety	2.6	4.3	6.3	1.5	-2.5
Tail length	7.7	41.2	44.6	-6.7	6.1
Length with tail	20.5	90.7	100.7	-10.0	9.0
Length without tail	7.8	41.1	47.4	-6.9	5.9
Times rat made contact with spout	0.7	0.9	1.0	-1.0	0.9
Lifetime Intake	0.3	0.3	0.3	0.6	-0.6
Liver weight, left	3.8	6.6	6.8	-2.5	2.6
Liver weight, right	3.7	6.4	7.2	-2.7	2.4
Locomotor activity	2.5	3.9	5.2	-1.6	2.3
Locomotor testing distance	0.6	1.5	2.1	-0.9	1.4
Locomotor testing rearing	0.0	0.0	0.0	0.1	0.2
Locomotion in novel chamber	1.6	2.1	2.7	-1.3	1.6
Locomotion in novel chamber post-restriction	1.2	3.7	4.6	-1.7	2.1
Fecal boli incidents, locomotor time 1	1.0	2.6	2.7	-1.6	1.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.3	-0.6
Time >=10cm from walls, locomotor time 1	2.2	2.7	3.0	1.5	-1.7
Bouts of movement, locomotor time 1	1.9	2.5	2.5	-1.6	1.6
Total resting periods, locomotor time 1	1.9	2.2	2.3	-1.5	1.5
Rest time, locomotor task time 1	1.2	2.0	2.3	-1.5	1.3
Distance moved, locomotor task time 1	0.2	0.7	0.9	1.0	-0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.0	0.4
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.5	-0.0
Bouts of movement, locomotor time 2	0.6	1.9	2.0	-1.4	1.4
Total resting periods, locomotor time 2	0.4	1.8	1.9	-1.4	1.3
Rest time, locomotor task time 2	0.1	0.2	0.3	0.5	-0.5
Distance moved, locomotor task time 2	0.1	0.2	0.2	-0.4	0.5
Vertical activity count, locomotor time 2	1.4	3.2	3.5	-1.7	1.9
Light reinforcement 1	0.6	2.9	3.1	1.7	-1.7
Light reinforcement 2	0.2	0.4	0.4	0.6	-0.6
Bone: marrow area	0.7	1.6	1.9	-1.2	1.4
Bone: maximum diameter	1.3	2.5	2.8	-1.7	1.5
Bone: maximum force	1.8	3.5	3.7	-1.9	1.8
Bone: maximum moment	1.6	2.9	2.9	-1.7	1.7
Mean time between licks in bursts	0.4	2.1	2.7	1.6	-1.2
Mean num. licks in bursts	0.1	0.2	0.2	0.4	-0.5
Cd content in liver	0.3	0.3	0.6	0.8	0.2
Co content in liver	1.0	1.2	1.3	-1.0	1.1
Cu content in liver	0.4	0.5	0.6	0.8	-0.6
Fe content in liver	0.2	0.2	0.4	-0.2	0.6
K content in liver	0.0	0.0	0.1	-0.3	-0.1
Mg content in liver	0.8	0.9	1.3	-1.1	0.7
Mn content in liver	0.1	0.2	0.2	0.4	-0.4
Na content in liver	1.1	1.3	1.6	-1.3	1.0
Rb content in liver	4.3	5.1	5.5	2.3	-2.2
Se content in liver	0.3	0.4	0.8	-0.9	0.1
Sr content in liver	0.7	0.6	0.7	-0.8	0.7
Zn content in liver	5.2	6.1	6.8	-2.6	2.3
Bone: minimum diameter	0.1	0.2	0.3	0.6	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.3	-0.6
Time in novel zone, hab. session 1	0.4	0.5	0.6	-0.8	0.6
Total zone transitions, hab. session 1	1.4	1.9	2.9	1.7	-1.0
Total locomotion distance, hab. session 1	0.8	1.1	1.4	1.2	-0.9
Locomotion velocity, hab. session 1	1.9	2.7	3.6	1.9	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.1	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	-0.1
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.3	0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.5	-0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.5	0.0
Novel to familiar place preference ratio	0.0	0.0	0.0	0.1	-0.1
Novelty place preference	0.2	0.2	0.2	0.5	-0.4
Time in novel zone, NPP test	0.1	0.1	0.1	0.3	-0.3
Total zone transitions, NPP test	0.0	0.0	0.0	0.2	0.2
Total locomotion distance, NPP test	0.1	0.1	0.3	0.5	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.1	0.4	0.2
Intraocular pressure	1.7	2.7	2.9	-1.6	1.7
Delta distance traveled before/after self-admin	0.3	0.4	0.6	-0.3	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.6	-0.0
Parametrial fat weight	0.1	0.1	0.2	-0.4	-0.3
Pavlov. Cond. lever latency	2.4	3.0	3.4	-1.8	1.6
Pavlov. Cond. magazine entry latency	0.5	0.7	0.9	-0.7	0.9
Pavlov. Cond. change in total contacts	1.1	1.2	1.4	1.1	-1.2
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	-0.2
Pavlov. Cond. latency score	0.3	0.3	0.4	0.6	-0.5
Pavlov. Cond. lever contacts	2.2	2.7	2.9	1.7	-1.6
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	0.5	-0.8
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.6	1.6	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.2	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.3	0.4
Pavlov. Cond. lever latency	0.7	0.9	1.1	-1.0	0.9
Pavlov. Cond. magazine entry latency	3.0	4.2	4.5	2.1	-2.0
Pavlov. Cond. change in total contacts	0.3	0.7	1.0	1.0	-0.5
Pavlov. Cond. index score	1.9	3.0	3.6	1.9	-1.5
Pavlov. Cond. latency score	1.7	2.7	3.1	1.8	-1.5
Pavlov. Cond. lever contacts	0.9	1.3	1.5	1.2	-1.1
Pavlov. Cond. magazine entry number	3.1	4.0	4.8	-2.2	1.8
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.2	-0.8	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.1	3.2	3.8	2.0	-1.6
Pavlov. Cond. response bias	1.8	2.5	3.1	1.7	-1.4
Time in closed arm before self-admin	1.8	3.1	3.8	-1.6	1.9
Time in closed arm after self-admin	3.1	3.5	4.3	-1.6	2.1
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	0.0
Time in open arm after self-admin	2.5	2.8	3.2	1.6	-1.8
Bone: periosteal estimation	1.2	2.7	2.8	-1.7	1.7
Bone: periosteal perimeter	0.3	0.5	0.8	-0.5	0.9
Bone: post-yield work	0.3	0.6	0.7	-0.7	0.8
Progressive ratio test 1 active lever presses	1.1	1.9	1.9	-1.4	1.4
Progressive ratio test 1 breakpoint	1.1	1.8	1.9	-1.4	1.3
Progressive ratio test 1 inactive lever presses	0.7	1.9	2.3	-1.2	1.5
Progressive ratio test 2 active lever presses	1.4	2.0	2.5	-1.2	1.6
Progressive ratio test 2 breakpoint	1.4	1.8	2.3	-1.1	1.5
Progressive ratio test 2 inactive lever presses	1.8	5.6	6.6	-2.2	2.6
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.1	-0.4
Progressive ratio	0.3	0.8	0.9	0.8	-1.0
Food seeking constrained by brief footshock	0.9	1.2	1.2	1.1	-1.1
Seeking ratio, punishment vs. effort	0.4	0.9	0.9	-0.9	1.0
Retroperitoneal fat weight	0.1	0.6	1.1	0.3	-1.1
Reaction time number correct	0.3	1.2	1.7	-0.8	1.3
Reaction time mean minus median	0.0	0.1	0.1	0.1	-0.3
Reaction time mean minus median AUC	0.1	0.9	1.0	1.0	-0.9
Reaction time num false alarms	0.0	0.1	0.1	0.4	0.1
Reaction time num false alarms AUC	0.0	0.1	0.1	0.0	0.4
Reaction time trials correct on left	0.3	1.2	1.7	-0.8	1.3
Reaction time trials on left	0.3	1.1	1.6	-0.7	1.3
Reaction time mean	2.2	4.9	5.6	2.0	-2.4
Reaction time mean AUC	2.1	5.1	5.6	2.1	-2.4
Median of all reaction times	4.3	6.8	7.6	2.4	-2.8
Reaction time omissions	0.7	1.1	1.3	0.9	-1.2
Reaction time false alarm rate	0.1	0.1	0.1	0.3	-0.2
Reaction time premature initiation rate	0.1	0.1	0.1	0.3	-0.4
Reaction time premature initiations	0.0	0.0	0.0	0.0	0.2
Std. dev. reaction times	0.4	1.2	1.6	0.9	-1.2
Reaction time trials completed	0.3	1.1	1.6	-0.7	1.3
Reaction time trials AUC	0.2	0.7	1.2	-0.5	1.1
Run reversals in cocaine runway, females	1.1	1.2	1.3	1.1	-1.1
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.2	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.1	-0.5
Latency to leave start box in cocaine runway, F	0.1	0.2	0.3	-0.6	-0.0
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.6	-0.4
Std. dev. time between licks in bursts	0.2	0.4	0.6	-0.5	0.8
Total sessions with >9 infusions	0.2	0.2	0.4	0.2	-0.6
Short access day 1 total inactive lever presses	0.1	0.3	0.4	-0.7	0.4
Short access day 10 total inactive lever presses	0.4	2.6	3.6	-1.9	1.3
Short access day 1 total infusions	0.8	1.5	2.0	1.0	-1.4
Short access day 10 total infusions	0.3	0.5	0.6	0.8	-0.7
Short access total infusions	1.0	1.4	1.9	0.9	-1.4
Short access day 1 locomotion	0.3	0.4	0.5	0.6	-0.7
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.1
Short access total locomotion	0.5	0.8	1.0	0.8	-1.0
One hour access (0.3 mA shock)	1.6	1.9	3.3	-0.7	1.8
Compulsive drug intake	1.8	2.7	3.3	1.8	-1.5
One hour access (shock baseline)	1.2	3.1	4.0	-1.5	2.0
Social response proportion	4.6	5.8	6.5	-2.6	2.3
Social responses	2.4	3.2	3.8	-1.6	1.9
Social time	2.2	3.4	4.2	2.0	-1.6
Soleus weight	1.6	4.6	4.7	-2.1	2.2
Bone: stiffness	0.5	0.9	1.1	-0.9	1.0
Tibialis anterior weight	7.5	25.8	29.6	-5.4	4.7
Time to tail flick, vehicle, before self-admin	1.2	1.4	2.0	0.9	-1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	0.2
Time to tail flick, test, before self-admin	1.9	2.2	2.2	-1.4	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	0.4
Delta time to tail flick, test, before/after SA	1.3	1.5	1.6	1.2	-1.3
Tibia length	4.7	13.0	17.2	-4.2	3.0
Ambulatory time before self-admin	0.0	0.2	0.2	0.4	-0.4
Ambulatory time after self-admin	0.2	0.3	0.6	0.7	-0.3
Bone: tissue strength	0.2	0.2	0.3	-0.5	0.5
Total heroin consumption	3.5	4.1	4.9	2.2	-1.8
Bone: trabecular number	3.3	6.3	8.1	-2.9	2.1
Bone: trabecular spacing	3.2	4.7	5.6	2.4	-2.0
Bone: trabecular thickness	3.6	5.0	6.1	-2.5	2.0
Bone: trabecular tissue density	0.0	0.0	0.0	-0.0	-0.1
Water consumed over 24 hours	2.4	4.6	5.0	-2.2	2.0
Number of responses in last shaping day	0.4	0.5	0.6	0.6	-0.8