Hub : Genes

LOC134480890

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio XR_010055854.1 0.34 0.22 8.6e-03 0.04 0.12 0.11 0.08 8.9e-02 7.9e-03 1.1e-02 2.3e-02
2 NAcc isoform ratio XR_010055854.1 0.01 0.01 9.4e-03 0.01 0.01 0 0 3.4e-02 2.2e-02 1.1e-01 5.3e-02
3 Brain gene expression LOC134480890 0.09 0.05 3.0e-05 0.06 0.06 0.06 0.06 2.7e-06 7.0e-06 3.0e-06 1.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.20.50.7-0.70.4-0.8
Area under the delay curve0.20.30.7-0.0-0.90.3
BMI with tail0.20.71.70.61.30.2
BMI without tail0.31.85.3-0.32.3-0.3
Body weight1.35.59.9-2.03.1-1.6
Weight adjusted by age0.82.54.01.6-2.00.9
Bone surface3.06.06.9-2.62.1-2.6
Bone volume2.03.94.7-2.21.6-2.1
Breakpoint value in progressive ratio session1.32.32.71.6-1.41.5
Number of licking bursts0.00.10.2-0.50.30.2
Context. condit. distance diff. score0.00.00.10.2-0.30.0
Locomotion velocity, session 10.10.10.2-0.40.4-0.3
Locomotion distance, session 10.00.00.0-0.0-0.10.0
Locomotion velocity, session 20.40.50.7-0.80.90.5
Locomotion distance, session 20.30.41.1-0.20.11.1
Locomotion velocity, session 32.42.74.81.2-1.42.2
Locomotion distance, session 30.30.30.60.1-0.80.6
Stereotopy head waving bouts, day 32.22.63.61.7-1.91.0
Stereotopy head waving duration, day 31.92.33.41.3-1.91.3
Locomotion velocity, session 70.60.61.61.3-0.60.1
Locomotion distance, session 70.10.10.1-0.30.2-0.3
Stereotopy head waving bouts, day 72.42.83.61.4-1.71.9
Stereotopy head waving duration, day 73.34.15.31.7-2.12.3
Locomotion velocity, session 80.20.30.70.00.2-0.9
Locomotion distance, session 80.10.10.1-0.30.40.0
Degree of sensitization distance0.70.71.3-0.40.8-1.2
Degree of sensitization stereotypy2.02.24.31.1-1.12.1
Conditioned locomotion0.10.10.20.20.1-0.5
Cocaine response after cond. corrected0.10.10.2-0.1-0.50.3
Cocaine response after cond. not corrected0.10.20.40.0-0.70.5
Cocaine response before conditioning0.10.10.20.0-0.40.4
Saline control response0.40.61.7-0.11.30.3
Bone: connectivity density0.50.91.1-1.00.8-1.0
Bone: cortical apparent density3.04.85.52.3-2.22.0
Bone: cortical area0.71.11.6-1.11.3-0.7
Bone: cortical porosity3.23.54.4-2.12.1-1.3
Bone: cortical porosity2.42.73.9-2.01.8-1.0
Bone: cortical thickness4.27.09.52.7-2.13.1
Bone: cortical thickness1.31.52.31.4-0.51.5
Bone: cortical tissue density3.04.75.52.3-2.12.0
Condit. Reinf. active minus inactive responses3.03.46.4-2.51.7-0.9
Condit. Reinf. active-inactive response ratio0.91.02.0-1.40.7-0.6
Condit. Reinf. active responses3.24.16.4-2.51.9-1.5
Condit. Reinf. inactive responses1.11.52.0-1.11.0-1.4
Incentive salience index mean1.62.03.4-1.81.5-0.8
Condit. Reinf. lever presses0.00.10.20.10.40.1
Condit. Reinf. active minus inactive responses4.57.012.8-3.62.6-1.2
Condit. Reinf. active-inactive response ratio2.33.76.8-2.61.9-0.8
Condit. Reinf. active responses6.49.214.4-3.83.1-1.9
Condit. Reinf. inactive responses1.92.83.3-1.81.8-1.4
Condit. Reinf. lever presses4.26.19.3-3.02.9-0.6
Condit. Reinf. lever reinforcers received6.49.013.8-3.73.1-1.8
Conditioned reinforcement - actives0.41.42.1-1.41.40.6
Conditioned reinforcement - inactives0.20.61.0-0.71.0-0.6
Conditioned locomotion2.02.94.3-1.82.1-1.1
Patch foraging indifference point 0 sec3.18.611.8-3.43.3-1.8
Patch foraging indifference point AUC0.20.60.8-0.70.9-0.6
Delay disc. indifference point, 0s delay0.91.01.60.9-1.20.7
Delay disc. indifference point, 16s delay0.10.10.2-0.4-0.20.4
Delay disc. indifference point, 2s delay0.40.50.9-0.6-0.2-1.0
Delay disc. indifference point, 24s delay0.30.50.9-0.90.7-0.4
Delay disc. indifference point, 4s delay0.70.81.60.5-1.30.7
Delay disc. indifference point, 8s delay0.61.12.20.8-1.50.6
Indifference point function ln k0.10.40.50.5-0.70.6
Indifference point function log k0.10.40.50.5-0.70.6
Patch foraging total patch changes 0 sec2.98.611.5-3.43.3-1.9
Patch foraging total patch changes 12 sec5.37.18.7-3.02.9-2.0
Patch foraging total patch changes 18 sec0.81.93.1-1.41.8-0.7
Patch foraging total patch changes 24 sec1.03.44.3-2.02.1-1.3
Patch foraging total patch changes 6 sec4.27.110.0-3.23.1-1.4
Patch foraging time to switch 0 sec0.20.61.00.6-0.61.0
Patch foraging water rate 0 sec0.93.43.9-1.72.0-1.9
Patch foraging water rate 12 sec0.00.20.50.1-0.10.7
Patch foraging water rate 18 sec0.00.00.0-0.20.10.1
Patch foraging water rate 24 sec0.30.41.00.4-1.00.1
Patch foraging water rate 6 sec0.10.20.30.6-0.40.1
Seeking ratio, delayed vs. immediate footshock0.10.10.20.4-0.30.2
Distance traveled before self-admin0.61.31.80.5-1.41.3
Distance traveled after self-admin0.20.40.6-0.80.10.8
Extensor digitorum longus weight1.66.415.03.9-2.00.5
Bone: elastic displacement1.11.41.51.1-1.21.2
Bone: elastic work0.10.10.30.50.2-0.3
Bone: endosteal estimation14.034.238.6-6.25.8-5.5
Bone: endosteal perimeter11.628.633.2-5.84.9-5.3
Epididymis fat weight0.10.30.90.10.90.0
Delta time in closed arm before/after self-admin0.40.30.40.6-0.5-0.6
Delta time in open arm before/after self-admin0.50.50.70.5-0.80.8
Diff in mean of infusions in LGA sessions1.32.43.21.8-1.11.6
Delay discount exponential model param0.10.10.40.30.60.1
Extinction: sum of active levers before priming0.50.81.51.2-0.90.2
Active lever presses in extinction session 60.60.60.9-0.91.0-0.4
Bone: final force1.11.82.2-1.51.3-1.2
Bone: final moment1.21.92.5-1.61.4-1.2
Food consumed during 24 hour testing period0.51.02.8-0.51.7-0.2
Glucose2.23.43.91.8-2.01.8
Heart weight0.30.51.10.2-0.61.0
Delay discount hyperbolic model param0.10.20.50.10.70.2
Intermittent access intake day 1-15 change0.10.50.7-0.40.8-0.8
Intermittent access intake escalation0.10.70.9-0.51.0-1.0
Intermittent access intake escalation 21.01.72.4-0.71.5-1.5
Intermitt. access day 1 inactive lever presses0.10.71.2-0.51.1-0.8
Intermitt. access day 15 inactive lever presses0.10.71.00.11.0-1.0
Intermitt. access escalation Index0.31.02.70.1-0.51.6
Intermittent access day 1 total infusions0.41.11.6-1.30.81.0
Intermittent access day 15 total infusions0.82.03.1-1.81.7-0.0
Intermittent access terminal intake (last 3 days)2.44.36.0-2.42.4-1.0
Intermittent access total infusions2.73.25.5-2.31.9-0.4
Intermittent access day 1 locomotion1.42.64.1-2.02.00.0
Intermittent access day 15 total locomotion1.45.68.2-2.62.9-1.2
Intermittent access total locomotion6.57.811.8-3.23.4-1.2
Intermittent access standard deviation0.20.81.3-0.70.8-1.1
Left kidney weight0.10.51.3-0.30.11.2
Right kidney weight0.10.51.5-0.20.01.2
Cocaine induced anxiety0.00.10.2-0.1-0.40.4
Post-drug Anxiety0.91.01.71.0-1.30.6
Baseline Anxiety0.60.91.91.4-0.80.6
Tail length1.47.310.2-2.83.2-2.0
Length with tail1.66.98.7-3.02.5-2.4
Length without tail0.10.60.9-0.80.4-1.0
Times rat made contact with spout0.60.71.4-0.81.2-0.5
Lifetime Intake2.12.64.4-2.11.8-0.2
Liver weight, left2.13.73.9-2.02.0-1.8
Liver weight, right0.61.02.70.5-0.21.7
Locomotor activity1.93.04.2-2.02.10.8
Locomotor testing distance0.61.62.4-1.41.50.7
Locomotor testing rearing0.20.82.2-0.41.5-0.4
Locomotion in novel chamber0.50.71.70.7-1.3-0.0
Locomotion in novel chamber post-restriction0.51.63.6-1.10.3-1.9
Fecal boli incidents, locomotor time 10.10.30.60.3-0.8-0.3
Change in fecal boli incidents, locomotor task0.40.40.7-0.80.7-0.4
Time >=10cm from walls, locomotor time 11.01.31.80.7-1.31.3
Bouts of movement, locomotor time 10.20.30.80.9-0.2-0.0
Total resting periods, locomotor time 10.40.41.01.0-0.4-0.3
Rest time, locomotor task time 10.91.52.61.6-1.3-0.4
Distance moved, locomotor task time 10.00.10.3-0.10.50.1
Vertical activity count, locomotor time 10.00.10.2-0.30.50.1
Time >=10cm from walls, locomotor time 20.41.12.81.7-0.60.5
Bouts of movement, locomotor time 20.31.12.61.6-0.60.7
Total resting periods, locomotor time 20.31.42.41.5-0.91.0
Rest time, locomotor task time 24.06.810.62.4-3.32.0
Distance moved, locomotor task time 20.50.61.30.51.2-0.5
Vertical activity count, locomotor time 21.22.76.1-0.92.5-1.1
Light reinforcement 10.20.82.00.6-0.21.4
Light reinforcement 20.41.01.70.9-1.30.6
Bone: marrow area13.533.136.9-6.15.7-5.4
Bone: maximum diameter4.18.111.7-3.42.4-2.6
Bone: maximum force1.63.14.3-2.11.7-1.4
Bone: maximum moment1.83.44.6-2.11.8-1.5
Mean time between licks in bursts0.00.10.20.10.1-0.4
Mean num. licks in bursts0.00.00.10.20.2-0.3
Cd content in liver1.31.42.01.4-1.3-0.7
Co content in liver1.51.72.51.4-1.60.8
Cu content in liver0.20.30.5-0.40.4-0.7
Fe content in liver0.40.41.1-1.10.50.1
K content in liver0.10.10.3-0.5-0.4-0.2
Mg content in liver0.20.20.40.2-0.60.3
Mn content in liver0.30.30.9-0.9-0.10.3
Na content in liver0.40.40.7-0.1-0.80.8
Rb content in liver0.60.71.2-0.0-0.91.1
Se content in liver1.72.13.40.5-1.81.6
Sr content in liver0.10.10.10.30.2-0.1
Zn content in liver0.50.51.10.3-1.10.6
Bone: minimum diameter11.021.123.3-4.84.6-4.4
Time in familiar zone, hab. session 11.51.62.6-1.01.1-1.6
Time in novel zone, hab. session 10.91.02.30.7-0.41.5
Total zone transitions, hab. session 10.10.10.4-0.10.60.2
Total locomotion distance, hab. session 10.50.81.7-0.81.30.1
Locomotion velocity, hab. session 10.40.51.1-0.71.1-0.2
Time in familiar zone, hab. session 21.31.52.1-0.91.2-1.5
Time in novel zone, hab. session 20.60.71.10.5-0.81.0
Total zone transitions, hab. session 20.20.30.40.60.20.7
Total locomotion distance, hab. session 20.20.20.60.10.8-0.2
Locomotion velocity, hab. session 20.10.10.20.30.5-0.1
Novel to familiar place preference ratio1.31.72.5-1.61.4-0.8
Novelty place preference0.70.91.4-1.21.1-0.5
Time in novel zone, NPP test0.80.91.5-1.21.1-0.3
Total zone transitions, NPP test0.20.30.90.10.00.9
Total locomotion distance, NPP test0.40.61.3-0.61.1-0.4
Locomotion velocity, NPP test0.10.10.4-0.20.6-0.0
Intraocular pressure0.50.82.1-0.60.31.4
Delta distance traveled before/after self-admin0.90.91.6-1.01.30.5
Delta ambulatory time before/after self-admin1.11.93.1-1.61.7-0.2
Parametrial fat weight0.41.02.9-0.30.1-1.7
Pavlov. Cond. lever latency0.30.40.80.5-0.9-0.4
Pavlov. Cond. magazine entry latency1.82.34.3-2.11.6-0.2
Pavlov. Cond. change in total contacts1.41.52.4-1.41.5-0.3
Pavlov. Cond. index score1.21.52.5-1.61.4-0.1
Pavlov. Cond. latency score0.81.01.5-1.21.20.1
Pavlov. Cond. lever contacts0.20.20.7-0.20.8-0.1
Pavlov. Cond. magazine entry number1.41.73.81.9-1.2-0.1
Pavlov. Cond. intertrial magazine entries1.51.82.9-1.71.1-1.0
Pavlov. Cond. lever-magazine prob. diff.1.11.42.4-1.61.3-0.0
Pavlov. Cond. response bias1.62.03.7-1.91.5-0.2
Pavlov. Cond. lever latency1.11.63.21.8-1.30.0
Pavlov. Cond. magazine entry latency1.42.03.00.8-1.51.7
Pavlov. Cond. change in total contacts0.30.71.5-1.20.7-0.3
Pavlov. Cond. index score0.40.61.2-1.10.50.6
Pavlov. Cond. latency score0.40.61.0-1.00.20.8
Pavlov. Cond. lever contacts0.91.32.4-1.61.20.2
Pavlov. Cond. magazine entry number2.32.94.2-1.11.8-2.1
Pavlov. Cond. intertrial magazine entries4.39.511.7-2.33.4-3.4
Pavlov. Cond. lever-magazine prob. diff.0.30.51.1-1.00.30.6
Pavlov. Cond. response bias0.50.71.4-1.20.70.2
Time in closed arm before self-admin0.71.31.8-1.21.30.8
Time in closed arm after self-admin0.00.00.10.10.3-0.1
Time in open arm before self-admin1.11.31.51.2-1.21.0
Time in open arm after self-admin0.70.81.50.7-1.20.5
Bone: periosteal estimation8.720.624.6-5.04.7-3.9
Bone: periosteal perimeter3.16.28.8-3.02.2-2.2
Bone: post-yield work1.42.42.6-1.61.5-1.6
Progressive ratio test 1 active lever presses2.13.76.1-2.32.50.2
Progressive ratio test 1 breakpoint2.44.16.9-2.32.6-0.0
Progressive ratio test 1 inactive lever presses1.64.16.9-2.32.6-0.6
Progressive ratio test 2 active lever presses1.21.83.6-1.91.3-0.2
Progressive ratio test 2 breakpoint1.62.04.0-2.01.4-0.4
Progressive ratio test 2 inactive lever presses0.31.01.7-1.31.1-0.1
Incentive Sensitization - Responses0.00.10.2-0.1-0.5-0.3
Incentive Sensitization - Breakpoint0.10.10.2-0.2-0.5-0.4
Sum of active levers in priming session hrs 5-61.11.02.50.5-0.61.6
Progressive ratio0.41.12.40.7-1.5-0.7
Food seeking constrained by brief footshock2.83.54.7-1.52.2-1.9
Seeking ratio, punishment vs. effort1.22.65.4-1.42.3-0.6
Retroperitoneal fat weight0.20.81.50.41.2-0.9
Reaction time number correct0.30.91.50.2-1.21.1
Reaction time mean minus median0.00.20.40.6-0.2-0.3
Reaction time mean minus median AUC0.00.10.2-0.3-0.20.4
Reaction time num false alarms1.22.03.8-1.91.3-0.6
Reaction time num false alarms AUC1.32.95.1-2.31.7-0.9
Reaction time trials correct on left0.30.91.50.2-1.21.1
Reaction time trials on left0.20.81.30.1-1.21.1
Reaction time mean0.00.10.1-0.2-0.40.1
Reaction time mean AUC0.00.10.1-0.0-0.30.3
Median of all reaction times0.10.10.2-0.4-0.30.3
Reaction time omissions0.61.01.2-0.91.0-1.1
Reaction time false alarm rate2.02.83.6-1.81.9-1.2
Reaction time premature initiation rate0.30.40.6-0.50.8-0.7
Reaction time premature initiations0.00.10.1-0.30.2-0.1
Std. dev. reaction times0.10.20.7-0.00.0-0.9
Reaction time trials completed0.20.81.30.1-1.21.1
Reaction time trials AUC0.20.71.20.2-1.10.9
Run reversals in cocaine runway, females2.32.66.82.6-1.10.1
Run reversals in cocaine runway, males0.40.41.10.5-1.0-0.2
Latency to leave start box in cocaine runway0.70.91.31.1-0.51.2
Latency to leave start box in cocaine runway, F1.82.23.61.3-1.21.9
Latency to leave start box in cocaine runway, M0.20.20.50.30.7-0.4
Std. dev. time between licks in bursts0.20.51.11.1-0.50.2
Total sessions with >9 infusions1.01.33.6-0.30.31.9
Short access day 1 total inactive lever presses0.10.30.5-0.60.7-0.0
Short access day 10 total inactive lever presses0.10.61.20.8-0.2-1.1
Short access day 1 total infusions0.91.75.1-0.2-0.32.3
Short access day 10 total infusions2.33.86.8-2.22.6-0.1
Short access total infusions1.01.41.9-1.41.30.7
Short access day 1 locomotion0.50.91.3-0.70.91.1
Short access day 10 total locomotion1.24.88.3-2.12.9-1.3
Short access total locomotion0.81.22.5-1.01.60.3
One hour access (0.3 mA shock)1.31.62.8-1.71.40.3
Compulsive drug intake0.50.71.3-1.10.40.7
One hour access (shock baseline)0.20.40.7-0.60.8-0.4
Social response proportion0.50.61.3-1.10.80.1
Social responses2.33.14.6-2.12.10.4
Social time0.00.00.1-0.1-0.30.0
Soleus weight0.10.20.40.0-0.50.6
Bone: stiffness1.11.93.0-1.71.3-1.0
Tibialis anterior weight0.10.51.11.10.6-0.1
Time to tail flick, vehicle, before self-admin0.20.30.3-0.6-0.5-0.4
Time to tail flick, vehicle, after self-admin0.20.40.5-0.7-0.4-0.7
Time to tail flick, test, before self-admin0.70.91.0-0.81.0-0.9
Time to tail flick, test, after self-admin1.31.42.4-1.61.30.1
Delta time to tail flick, vehicle, before/after SA1.31.42.2-0.81.1-1.5
Delta time to tail flick, test, before/after SA0.10.10.2-0.4-0.40.0
Tibia length0.20.61.1-1.1-0.00.8
Ambulatory time before self-admin0.41.32.00.8-1.41.1
Ambulatory time after self-admin0.10.20.3-0.60.20.6
Bone: tissue strength1.21.21.90.6-1.41.2
Total heroin consumption0.40.40.7-0.90.00.7
Bone: trabecular number0.30.70.9-1.00.4-0.9
Bone: trabecular spacing0.10.20.30.5-0.10.4
Bone: trabecular thickness0.60.81.0-1.00.7-1.0
Bone: trabecular tissue density0.40.71.20.5-1.10.9
Water consumed over 24 hours0.10.20.30.20.60.3
Number of responses in last shaping day0.50.60.80.8-0.90.6