Hub : Genes

LOC134480869

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC134480869 0.13 0.07 5.6e-17 0.1 0.11 0.15 0.12 1.5e-11 6.8e-12 5.5e-16 4.2e-13
2 Brain gene expression LOC134480869 0.04 0.03 4.4e-04 0.02 0.03 0.02 0.02 2.7e-03 1.3e-03 4.1e-03 2.4e-03
3 PL gene expression LOC134480869 0.04 0.03 1.4e-04 0.03 0.04 0.03 0.03 1.9e-04 8.7e-05 1.6e-04 1.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.62.73.21.6-1.5-1.8
Area under the delay curve0.50.60.70.7-0.8-0.8
BMI with tail3.411.712.5-3.53.53.2
BMI without tail1.95.96.7-2.62.52.2
Body weight7.733.735.6-6.05.95.5
Weight adjusted by age0.10.20.3-0.40.60.1
Bone surface0.10.10.3-0.40.50.2
Bone volume0.00.10.1-0.10.4-0.0
Breakpoint value in progressive ratio session0.00.00.00.10.0-0.1
Number of licking bursts0.00.00.10.10.30.1
Context. condit. distance diff. score0.40.40.6-0.70.40.8
Locomotion velocity, session 10.80.81.0-1.01.00.8
Locomotion distance, session 13.64.55.4-2.32.11.9
Locomotion velocity, session 20.10.10.1-0.40.30.3
Locomotion distance, session 20.50.71.0-1.00.90.6
Locomotion velocity, session 30.10.10.20.3-0.4-0.3
Locomotion distance, session 30.30.30.3-0.60.50.5
Stereotopy head waving bouts, day 33.03.64.01.7-2.0-2.0
Stereotopy head waving duration, day 30.20.20.30.3-0.6-0.6
Locomotion velocity, session 71.71.92.2-1.21.51.3
Locomotion distance, session 70.81.01.2-0.91.01.1
Stereotopy head waving bouts, day 70.60.71.00.7-0.8-1.0
Stereotopy head waving duration, day 70.40.50.70.5-0.7-0.9
Locomotion velocity, session 86.78.18.6-2.92.72.9
Locomotion distance, session 81.52.22.7-1.61.41.4
Degree of sensitization distance1.21.21.5-1.01.11.2
Degree of sensitization stereotypy0.50.60.80.7-0.7-0.9
Conditioned locomotion0.50.50.50.7-0.7-0.7
Cocaine response after cond. corrected0.10.20.40.2-0.2-0.6
Cocaine response after cond. not corrected0.20.20.40.3-0.2-0.7
Cocaine response before conditioning0.00.00.10.2-0.2-0.1
Saline control response0.81.11.2-1.11.10.9
Bone: connectivity density2.74.24.72.0-2.0-2.2
Bone: cortical apparent density7.39.910.73.3-3.3-2.9
Bone: cortical area0.10.10.20.5-0.2-0.3
Bone: cortical porosity0.10.10.30.3-0.2-0.5
Bone: cortical porosity0.00.00.1-0.10.3-0.2
Bone: cortical thickness1.62.62.81.7-1.6-1.6
Bone: cortical thickness6.67.88.42.7-2.8-2.9
Bone: cortical tissue density7.29.810.63.2-3.3-2.9
Condit. Reinf. active minus inactive responses2.02.22.41.5-1.5-1.4
Condit. Reinf. active-inactive response ratio2.72.93.21.8-1.8-1.5
Condit. Reinf. active responses1.62.02.11.4-1.5-1.4
Condit. Reinf. inactive responses0.00.00.00.1-0.1-0.2
Incentive salience index mean2.63.23.51.9-1.8-1.7
Condit. Reinf. lever presses1.01.41.81.4-1.1-1.1
Condit. Reinf. active minus inactive responses0.81.01.21.1-0.9-1.0
Condit. Reinf. active-inactive response ratio0.50.50.60.8-0.7-0.8
Condit. Reinf. active responses1.11.51.81.3-1.1-1.3
Condit. Reinf. inactive responses1.01.31.51.2-1.0-1.2
Condit. Reinf. lever presses0.20.20.30.5-0.5-0.5
Condit. Reinf. lever reinforcers received1.52.12.41.6-1.3-1.4
Conditioned reinforcement - actives0.10.10.30.5-0.2-0.1
Conditioned reinforcement - inactives0.20.20.30.6-0.5-0.3
Conditioned locomotion0.40.50.91.0-0.6-0.5
Patch foraging indifference point 0 sec1.62.93.41.8-1.8-1.5
Patch foraging indifference point AUC0.00.00.1-0.20.20.1
Delay disc. indifference point, 0s delay1.82.02.21.5-1.3-1.4
Delay disc. indifference point, 16s delay0.91.01.40.8-1.2-1.1
Delay disc. indifference point, 2s delay0.60.60.80.9-0.6-0.8
Delay disc. indifference point, 24s delay0.00.00.1-0.20.10.2
Delay disc. indifference point, 4s delay1.61.71.91.4-1.2-1.4
Delay disc. indifference point, 8s delay0.10.10.20.4-0.3-0.2
Indifference point function ln k0.10.10.20.3-0.4-0.2
Indifference point function log k0.10.10.20.3-0.4-0.2
Patch foraging total patch changes 0 sec0.91.72.11.4-1.4-1.1
Patch foraging total patch changes 12 sec3.34.34.72.2-2.0-2.1
Patch foraging total patch changes 18 sec0.20.30.50.7-0.4-0.3
Patch foraging total patch changes 24 sec0.71.11.21.1-1.0-1.1
Patch foraging total patch changes 6 sec1.31.92.11.5-1.4-1.3
Patch foraging time to switch 0 sec0.00.00.10.1-0.2-0.3
Patch foraging water rate 0 sec0.10.20.30.5-0.5-0.4
Patch foraging water rate 12 sec0.00.00.00.2-0.1-0.1
Patch foraging water rate 18 sec0.30.50.70.6-0.6-0.8
Patch foraging water rate 24 sec0.50.60.70.9-0.8-0.7
Patch foraging water rate 6 sec2.02.93.11.8-1.6-1.7
Seeking ratio, delayed vs. immediate footshock0.40.50.60.8-0.8-0.5
Distance traveled before self-admin0.10.10.20.3-0.1-0.4
Distance traveled after self-admin0.40.50.6-0.80.70.6
Extensor digitorum longus weight8.633.837.1-5.65.86.1
Bone: elastic displacement0.00.10.1-0.20.10.3
Bone: elastic work0.00.00.10.1-0.1-0.3
Bone: endosteal estimation3.57.78.4-2.82.92.6
Bone: endosteal perimeter1.94.14.4-1.92.12.1
Epididymis fat weight0.20.60.9-0.71.00.7
Delta time in closed arm before/after self-admin4.94.55.1-2.32.12.0
Delta time in open arm before/after self-admin0.00.00.00.0-0.2-0.2
Diff in mean of infusions in LGA sessions0.00.00.10.2-0.1-0.2
Delay discount exponential model param0.40.40.5-0.60.70.7
Extinction: sum of active levers before priming2.02.22.4-1.51.51.4
Active lever presses in extinction session 60.10.10.40.00.1-0.6
Bone: final force0.10.20.30.4-0.1-0.5
Bone: final moment0.00.10.10.30.0-0.4
Food consumed during 24 hour testing period0.81.11.1-1.11.01.0
Glucose0.10.20.3-0.30.60.3
Heart weight3.75.75.8-2.42.32.4
Delay discount hyperbolic model param0.30.40.4-0.60.60.6
Intermittent access intake day 1-15 change0.10.30.40.4-0.5-0.6
Intermittent access intake escalation0.10.20.30.3-0.5-0.5
Intermittent access intake escalation 20.20.20.3-0.50.40.4
Intermitt. access day 1 inactive lever presses0.83.13.71.6-1.8-1.9
Intermitt. access day 15 inactive lever presses1.63.23.51.9-1.9-1.6
Intermitt. access escalation Index1.31.92.6-1.61.41.1
Intermittent access day 1 total infusions0.00.00.00.2-0.2-0.2
Intermittent access day 15 total infusions0.10.20.30.3-0.5-0.5
Intermittent access terminal intake (last 3 days)0.30.40.50.5-0.7-0.7
Intermittent access total infusions0.10.10.20.3-0.4-0.4
Intermittent access day 1 locomotion0.00.00.10.2-0.10.0
Intermittent access day 15 total locomotion0.00.10.10.4-0.3-0.3
Intermittent access total locomotion0.80.91.01.0-1.0-0.9
Intermittent access standard deviation1.32.73.01.6-1.7-1.6
Left kidney weight0.21.01.3-1.11.00.8
Right kidney weight0.00.10.2-0.50.4-0.0
Cocaine induced anxiety2.53.54.5-2.11.81.7
Post-drug Anxiety0.50.60.8-0.90.70.7
Baseline Anxiety1.72.02.71.6-1.3-1.2
Tail length0.31.01.2-1.11.01.0
Length with tail2.18.99.4-3.13.12.8
Length without tail3.210.411.3-3.13.43.2
Times rat made contact with spout0.30.30.40.6-0.5-0.5
Lifetime Intake0.40.50.60.6-0.8-0.7
Liver weight, left0.50.91.1-0.91.00.9
Liver weight, right0.40.71.20.4-0.9-1.1
Locomotor activity0.20.30.40.5-0.3-0.6
Locomotor testing distance1.62.93.21.8-1.6-1.8
Locomotor testing rearing5.210.510.83.2-3.3-3.2
Locomotion in novel chamber4.55.86.32.4-2.3-2.5
Locomotion in novel chamber post-restriction0.10.10.20.3-0.2-0.4
Fecal boli incidents, locomotor time 10.40.60.7-0.70.70.8
Change in fecal boli incidents, locomotor task0.10.10.10.3-0.2-0.3
Time >=10cm from walls, locomotor time 10.40.40.60.8-0.6-0.4
Bouts of movement, locomotor time 10.40.40.5-0.70.70.5
Total resting periods, locomotor time 11.21.31.5-1.21.21.0
Rest time, locomotor task time 10.10.10.2-0.40.40.3
Distance moved, locomotor task time 10.10.10.10.2-0.3-0.4
Vertical activity count, locomotor time 10.10.10.2-0.30.40.4
Time >=10cm from walls, locomotor time 20.81.11.91.4-0.8-0.9
Bouts of movement, locomotor time 20.60.91.11.1-0.9-0.9
Total resting periods, locomotor time 20.40.60.80.9-0.8-0.7
Rest time, locomotor task time 20.81.01.2-1.11.01.0
Distance moved, locomotor task time 20.20.20.3-0.60.50.3
Vertical activity count, locomotor time 20.30.40.5-0.70.60.6
Light reinforcement 11.84.44.62.1-2.1-2.2
Light reinforcement 20.10.10.40.1-0.3-0.6
Bone: marrow area3.37.37.8-2.82.82.5
Bone: maximum diameter0.00.00.00.10.1-0.1
Bone: maximum force0.20.30.5-0.50.70.4
Bone: maximum moment0.30.50.8-0.70.90.6
Mean time between licks in bursts1.33.23.8-1.51.82.0
Mean num. licks in bursts0.20.30.50.4-0.7-0.5
Cd content in liver1.51.71.8-1.31.21.3
Co content in liver1.21.41.7-1.21.01.3
Cu content in liver0.40.50.50.7-0.7-0.6
Fe content in liver2.32.93.2-1.81.71.5
K content in liver2.22.12.61.3-1.4-1.6
Mg content in liver2.52.53.01.4-1.7-1.6
Mn content in liver2.52.83.01.7-1.7-1.5
Na content in liver0.10.10.30.10.0-0.5
Rb content in liver1.41.61.91.2-1.4-1.2
Se content in liver10.011.812.33.4-3.4-3.5
Sr content in liver0.20.10.20.5-0.4-0.1
Zn content in liver4.85.35.82.2-2.4-2.4
Bone: minimum diameter0.71.31.6-1.11.21.1
Time in familiar zone, hab. session 10.10.10.2-0.30.4-0.0
Time in novel zone, hab. session 11.21.21.71.1-1.3-0.8
Total zone transitions, hab. session 11.52.02.3-1.51.31.4
Total locomotion distance, hab. session 10.00.10.10.0-0.3-0.2
Locomotion velocity, hab. session 10.10.10.2-0.40.20.2
Time in familiar zone, hab. session 20.40.40.70.4-0.5-0.8
Time in novel zone, hab. session 20.30.30.50.7-0.5-0.3
Total zone transitions, hab. session 21.51.92.0-1.41.41.4
Total locomotion distance, hab. session 20.60.80.9-0.90.80.8
Locomotion velocity, hab. session 20.81.01.2-1.11.01.0
Novel to familiar place preference ratio0.20.20.2-0.50.40.5
Novelty place preference0.10.10.1-0.30.20.4
Time in novel zone, NPP test0.00.00.00.0-0.10.0
Total zone transitions, NPP test1.52.22.5-1.41.61.4
Total locomotion distance, NPP test0.40.50.7-0.80.70.7
Locomotion velocity, NPP test1.01.41.6-1.31.11.1
Intraocular pressure3.75.35.8-2.32.22.4
Delta distance traveled before/after self-admin1.11.21.5-1.20.91.1
Delta ambulatory time before/after self-admin1.82.22.7-1.71.41.4
Parametrial fat weight0.20.50.80.6-0.5-0.9
Pavlov. Cond. lever latency0.91.11.4-1.00.91.2
Pavlov. Cond. magazine entry latency7.910.111.43.1-3.0-3.4
Pavlov. Cond. change in total contacts10.611.311.53.3-3.4-3.4
Pavlov. Cond. index score5.77.28.02.7-2.5-2.8
Pavlov. Cond. latency score3.94.95.72.2-2.0-2.4
Pavlov. Cond. lever contacts1.31.62.01.3-1.1-1.4
Pavlov. Cond. magazine entry number10.913.714.6-3.73.63.8
Pavlov. Cond. intertrial magazine entries0.81.01.1-1.00.91.1
Pavlov. Cond. lever-magazine prob. diff.7.28.99.83.0-2.8-3.1
Pavlov. Cond. response bias8.810.811.63.3-3.2-3.4
Pavlov. Cond. lever latency0.30.40.5-0.70.60.7
Pavlov. Cond. magazine entry latency0.10.10.1-0.20.30.3
Pavlov. Cond. change in total contacts0.61.01.31.1-1.0-0.8
Pavlov. Cond. index score0.00.00.10.2-0.1-0.2
Pavlov. Cond. latency score0.00.00.00.1-0.0-0.1
Pavlov. Cond. lever contacts0.20.30.40.6-0.5-0.6
Pavlov. Cond. magazine entry number0.00.00.1-0.20.20.2
Pavlov. Cond. intertrial magazine entries0.50.71.0-0.80.71.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.0-0.1
Pavlov. Cond. response bias0.70.91.01.0-0.8-1.0
Time in closed arm before self-admin2.02.63.21.5-1.8-1.5
Time in closed arm after self-admin0.00.00.10.0-0.3-0.0
Time in open arm before self-admin1.21.31.7-1.01.31.1
Time in open arm after self-admin0.20.20.2-0.40.40.4
Bone: periosteal estimation0.61.31.7-1.11.31.0
Bone: periosteal perimeter1.32.32.8-1.41.71.5
Bone: post-yield work1.31.92.0-1.31.41.4
Progressive ratio test 1 active lever presses0.10.10.10.3-0.3-0.4
Progressive ratio test 1 breakpoint0.00.00.10.2-0.2-0.2
Progressive ratio test 1 inactive lever presses0.40.60.60.7-0.8-0.8
Progressive ratio test 2 active lever presses1.11.31.71.3-1.1-1.0
Progressive ratio test 2 breakpoint1.21.31.71.3-1.1-1.1
Progressive ratio test 2 inactive lever presses0.20.30.30.6-0.5-0.4
Incentive Sensitization - Responses1.11.62.21.5-1.1-1.1
Incentive Sensitization - Breakpoint1.11.42.01.4-1.1-1.0
Sum of active levers in priming session hrs 5-60.00.00.1-0.0-0.0-0.4
Progressive ratio0.10.10.10.3-0.1-0.4
Food seeking constrained by brief footshock0.20.20.40.4-0.4-0.6
Seeking ratio, punishment vs. effort0.00.00.0-0.20.00.1
Retroperitoneal fat weight0.00.10.10.2-0.3-0.3
Reaction time number correct0.71.31.6-1.01.21.2
Reaction time mean minus median0.20.60.8-0.70.70.9
Reaction time mean minus median AUC0.00.10.1-0.20.20.4
Reaction time num false alarms0.00.10.10.3-0.1-0.3
Reaction time num false alarms AUC0.00.00.00.20.1-0.1
Reaction time trials correct on left0.71.31.6-1.01.21.2
Reaction time trials on left0.71.21.5-1.01.21.1
Reaction time mean0.60.91.20.9-1.1-0.9
Reaction time mean AUC0.61.01.30.9-1.1-1.0
Median of all reaction times1.92.83.11.6-1.8-1.6
Reaction time omissions0.40.60.70.7-0.8-0.8
Reaction time false alarm rate0.30.50.50.7-0.6-0.7
Reaction time premature initiation rate0.71.01.60.7-1.0-1.2
Reaction time premature initiations0.00.00.1-0.1-0.0-0.3
Std. dev. reaction times0.00.00.0-0.0-0.10.1
Reaction time trials completed0.71.21.5-1.01.21.1
Reaction time trials AUC0.61.11.3-0.91.21.1
Run reversals in cocaine runway, females0.50.50.7-0.90.50.7
Run reversals in cocaine runway, males0.20.20.20.4-0.5-0.4
Latency to leave start box in cocaine runway1.01.11.3-0.91.01.2
Latency to leave start box in cocaine runway, F1.41.61.6-1.21.31.3
Latency to leave start box in cocaine runway, M0.20.20.20.5-0.5-0.2
Std. dev. time between licks in bursts0.20.30.3-0.40.60.5
Total sessions with >9 infusions0.50.70.80.8-0.9-0.7
Short access day 1 total inactive lever presses1.82.32.71.4-1.6-1.6
Short access day 10 total inactive lever presses0.00.00.00.2-0.2-0.0
Short access day 1 total infusions0.91.21.40.9-1.2-1.2
Short access day 10 total infusions0.50.60.60.7-0.8-0.8
Short access total infusions0.70.91.10.8-1.0-1.0
Short access day 1 locomotion1.31.71.91.2-1.4-1.3
Short access day 10 total locomotion0.61.21.41.2-1.1-1.0
Short access total locomotion0.20.30.30.5-0.6-0.4
One hour access (0.3 mA shock)0.10.10.1-0.10.30.3
Compulsive drug intake0.00.00.10.2-0.30.2
One hour access (shock baseline)0.00.00.10.1-0.1-0.2
Social response proportion0.40.40.6-0.80.60.6
Social responses0.10.10.1-0.30.40.1
Social time0.50.70.9-0.81.00.7
Soleus weight0.31.01.4-0.91.20.8
Bone: stiffness0.00.00.1-0.20.3-0.1
Tibialis anterior weight1.86.26.8-2.62.52.3
Time to tail flick, vehicle, before self-admin0.10.20.3-0.20.40.5
Time to tail flick, vehicle, after self-admin0.00.00.10.00.20.1
Time to tail flick, test, before self-admin1.21.31.5-1.21.11.0
Time to tail flick, test, after self-admin0.20.20.2-0.40.50.4
Delta time to tail flick, vehicle, before/after SA0.10.10.20.3-0.0-0.4
Delta time to tail flick, test, before/after SA1.51.51.91.4-1.2-1.1
Tibia length2.56.97.5-2.72.72.4
Ambulatory time before self-admin0.00.10.10.3-0.2-0.3
Ambulatory time after self-admin1.72.02.6-1.61.41.2
Bone: tissue strength1.61.62.2-1.11.31.5
Total heroin consumption1.41.72.21.3-1.1-1.5
Bone: trabecular number3.86.37.42.5-2.3-2.7
Bone: trabecular spacing2.73.53.9-1.92.01.8
Bone: trabecular thickness0.00.00.00.2-0.1-0.1
Bone: trabecular tissue density0.20.30.50.4-0.7-0.3
Water consumed over 24 hours0.40.50.6-0.60.70.7
Number of responses in last shaping day0.40.50.80.6-0.9-0.5