Hub : Genes

LOC134480868

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC134480868	0.02	0.02	3.9e-03	0.01	0.01	0.01	0.01	5.8e-02	2.5e-02	7.8e-02	6.8e-02
2	Adipose	gene expression	LOC134480868	0.06	0.04	1.1e-07	0.07	0.05	0.06	0.06	4.0e-08	2.5e-06	3.1e-07	2.2e-07
3	Liver	intron excision ratio	chr10_84489158_84489778	0.14	0.08	9.7e-11	0.09	0.09	0.07	0.09	3.4e-10	3.6e-10	1.0e-08	1.7e-10
4	Liver	intron excision ratio	chr10_84486693_84489778	0.09	0.05	1.1e-07	0.06	0.06	0.05	0.06	2.4e-07	9.3e-08	1.1e-06	2.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.0	1.9	3.8	-1.9	-2.0	0.3	-0.6
Area under the delay curve	0.4	0.6	0.8	-0.9	-0.7	-0.5	0.8
BMI with tail	2.1	7.3	9.6	3.1	2.7	2.9	-1.9
BMI without tail	0.7	3.8	4.9	2.1	1.9	2.2	-1.5
Body weight	4.4	19.2	27.4	5.2	5.1	4.1	-2.7
Weight adjusted by age	0.3	1.0	3.0	0.0	0.1	1.7	-1.0
Bone surface	0.6	1.2	2.9	0.1	-0.2	1.3	-1.7
Bone volume	1.0	1.9	4.4	-0.1	-0.5	1.8	-2.1
Breakpoint value in progressive ratio session	0.0	0.1	0.1	-0.1	-0.1	0.4	-0.2
Number of licking bursts	0.4	1.3	3.3	0.1	-0.6	1.3	-1.8
Context. condit. distance diff. score	2.1	2.6	4.1	0.7	1.6	-1.7	2.0
Locomotion velocity, session 1	0.6	0.7	0.8	0.7	0.8	0.9	-0.9
Locomotion distance, session 1	2.2	2.8	3.1	1.8	1.6	1.7	-1.6
Locomotion velocity, session 2	0.1	0.1	0.2	0.3	0.4	-0.1	0.1
Locomotion distance, session 2	1.0	1.4	2.8	0.5	0.1	1.7	-1.6
Locomotion velocity, session 3	0.3	0.3	0.7	-0.3	-0.1	-0.9	0.6
Locomotion distance, session 3	0.1	0.2	0.3	0.5	0.4	0.3	-0.4
Stereotopy head waving bouts, day 3	2.1	2.5	4.0	-2.0	-1.5	-1.4	1.4
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.7	-0.2	-0.5	0.7
Locomotion velocity, session 7	1.5	1.7	2.4	1.4	0.9	1.3	-1.5
Locomotion distance, session 7	0.7	0.8	1.4	1.2	0.6	0.6	-1.1
Stereotopy head waving bouts, day 7	0.4	0.5	1.2	-1.1	-0.8	0.0	0.2
Stereotopy head waving duration, day 7	0.3	0.4	1.0	-1.0	-0.5	-0.1	0.5
Locomotion velocity, session 8	3.8	4.6	10.4	2.8	3.2	0.2	0.4
Locomotion distance, session 8	0.7	1.0	2.4	1.2	1.5	0.4	-0.2
Degree of sensitization distance	0.7	0.7	1.7	1.3	1.1	0.1	-0.3
Degree of sensitization stereotypy	0.4	0.4	1.0	-1.0	-0.8	0.3	-0.0
Conditioned locomotion	0.4	0.4	0.6	-0.8	-0.5	-0.7	0.6
Cocaine response after cond. corrected	0.6	1.0	1.8	-0.8	-0.8	1.3	-0.9
Cocaine response after cond. not corrected	0.8	1.2	2.0	-0.8	-0.9	1.4	-1.1
Cocaine response before conditioning	0.0	0.0	0.2	-0.1	0.0	-0.4	-0.0
Saline control response	0.5	0.7	0.9	0.8	1.0	0.9	-0.6
Bone: connectivity density	1.6	2.5	5.2	-2.2	-2.3	-0.2	-0.3
Bone: cortical apparent density	3.8	6.0	7.7	-2.8	-2.4	-2.6	1.9
Bone: cortical area	0.0	0.1	0.2	-0.3	-0.2	0.1	-0.4
Bone: cortical porosity	0.5	0.6	0.8	-0.6	-0.6	0.9	-0.8
Bone: cortical porosity	0.6	0.6	1.5	-0.2	-0.2	1.2	-0.9
Bone: cortical thickness	0.9	1.5	2.4	-1.6	-1.1	-1.1	1.0
Bone: cortical thickness	3.7	4.5	8.9	-3.0	-2.3	-1.4	1.4
Bone: cortical tissue density	3.7	5.9	7.6	-2.8	-2.5	-2.6	1.9
Condit. Reinf. active minus inactive responses	1.4	1.5	1.9	-1.4	-1.2	-1.1	1.2
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.0	-1.5	-1.2	-1.7	1.5
Condit. Reinf. active responses	1.0	1.2	1.7	-1.3	-1.2	-0.9	1.0
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	-0.4	0.6	-0.4
Incentive salience index mean	1.2	1.6	2.8	-1.6	-1.7	-0.8	0.5
Condit. Reinf. lever presses	0.6	0.9	1.9	-1.0	-1.4	0.1	-0.7
Condit. Reinf. active minus inactive responses	0.6	0.9	1.8	-0.9	-1.3	0.4	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.9	1.5	-0.7	-1.2	0.7	-1.0
Condit. Reinf. active responses	1.1	1.6	3.0	-1.2	-1.7	0.7	-1.2
Condit. Reinf. inactive responses	0.8	1.1	2.3	-1.2	-1.5	0.5	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.2
Condit. Reinf. lever reinforcers received	1.1	1.5	3.2	-1.4	-1.8	0.3	-0.9
Conditioned reinforcement - actives	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.2
Conditioned reinforcement - inactives	0.1	0.2	0.7	-0.2	-0.4	-0.8	0.4
Conditioned locomotion	0.3	0.5	0.9	-0.4	-1.0	0.2	-0.9
Patch foraging indifference point 0 sec	0.6	1.7	2.5	-1.3	-1.6	-1.5	0.3
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.0	0.2	0.2	-0.2
Delay disc. indifference point, 0s delay	0.9	1.1	2.2	-1.4	-1.5	-0.4	0.0
Delay disc. indifference point, 16s delay	1.9	2.7	5.6	-1.2	-0.3	-1.9	2.4
Delay disc. indifference point, 2s delay	0.8	0.8	1.5	-0.8	-1.2	0.7	-0.9
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	0.2	0.3	-0.7	0.7
Delay disc. indifference point, 4s delay	1.0	1.1	2.1	-1.5	-1.4	-0.1	0.5
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	-0.2	-0.5	-0.2	-0.1
Indifference point function ln k	0.2	0.7	1.5	-0.2	0.1	-1.2	1.2
Indifference point function log k	0.2	0.7	1.5	-0.2	0.1	-1.2	1.2
Patch foraging total patch changes 0 sec	0.4	1.0	1.8	-0.9	-1.2	-1.3	0.1
Patch foraging total patch changes 12 sec	2.2	3.0	6.2	-2.1	-2.5	-0.0	-1.2
Patch foraging total patch changes 18 sec	0.1	0.3	0.4	-0.2	-0.7	-0.3	-0.7
Patch foraging total patch changes 24 sec	0.2	0.7	1.2	-1.1	-1.1	-0.2	-0.3
Patch foraging total patch changes 6 sec	0.6	1.0	1.9	-1.3	-1.4	-0.8	-0.1
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.3	-0.3	0.4	-0.4
Patch foraging water rate 0 sec	0.0	0.2	0.3	-0.3	-0.4	-0.6	0.3
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.1	0.0	-0.3	0.1
Patch foraging water rate 18 sec	0.3	0.6	0.9	-0.9	-0.9	0.4	-0.8
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.7	-0.8	-0.4	-0.2
Patch foraging water rate 6 sec	1.1	1.6	3.3	-1.7	-1.8	-0.5	0.1
Seeking ratio, delayed vs. immediate footshock	1.2	1.7	3.7	-0.4	0.1	-1.7	1.9
Distance traveled before self-admin	0.2	0.3	0.8	-0.5	-0.4	0.9	-0.4
Distance traveled after self-admin	0.1	0.2	0.5	0.5	0.7	0.5	0.1
Extensor digitorum longus weight	4.8	19.1	37.7	6.1	6.1	1.1	-0.3
Bone: elastic displacement	0.0	0.1	0.2	0.4	0.2	-0.0	-0.1
Bone: elastic work	0.1	0.1	0.3	-0.3	-0.2	0.5	-0.3
Bone: endosteal estimation	2.3	5.6	6.3	2.5	2.0	2.4	-2.4
Bone: endosteal perimeter	1.2	2.9	4.3	2.1	1.6	1.4	-1.7
Epididymis fat weight	0.2	0.9	1.7	0.6	0.5	1.3	-1.1
Delta time in closed arm before/after self-admin	2.3	2.1	4.4	1.9	2.1	0.8	-0.1
Delta time in open arm before/after self-admin	0.2	0.3	0.9	-0.2	0.2	-0.4	0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.3	-0.3	0.5	-0.4
Delay discount exponential model param	0.4	0.5	0.8	0.8	0.5	0.6	-0.9
Extinction: sum of active levers before priming	0.8	1.2	1.9	1.4	1.4	0.9	-0.6
Active lever presses in extinction session 6	2.4	2.4	6.0	-0.8	-0.7	2.5	-1.6
Bone: final force	0.8	1.3	2.5	-0.6	-0.8	1.3	-1.6
Bone: final moment	0.7	1.2	2.4	-0.4	-0.6	1.4	-1.5
Food consumed during 24 hour testing period	0.3	0.6	1.1	1.0	1.0	0.4	-0.4
Glucose	0.4	0.6	1.2	0.2	0.2	1.0	-1.1
Heart weight	2.0	3.2	6.4	2.4	2.5	0.7	-0.6
Delay discount hyperbolic model param	0.3	0.4	0.5	0.7	0.6	0.4	-0.7
Intermittent access intake day 1-15 change	0.1	0.3	0.5	-0.7	-0.5	-0.2	0.6
Intermittent access intake escalation	0.0	0.3	0.4	-0.6	-0.4	-0.3	0.7
Intermittent access intake escalation 2	0.0	0.1	0.1	0.3	0.3	0.3	-0.0
Intermitt. access day 1 inactive lever presses	0.2	2.1	4.3	-2.1	-1.5	-0.8	1.1
Intermitt. access day 15 inactive lever presses	0.4	2.3	2.7	-1.6	-1.7	-1.6	1.2
Intermitt. access escalation Index	0.3	0.9	2.4	0.9	1.5	0.7	0.1
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.1	0.1	-0.4	0.3
Intermittent access day 15 total infusions	0.3	0.7	1.5	-0.6	-0.0	-0.9	1.2
Intermittent access terminal intake (last 3 days)	0.4	0.7	1.1	-0.7	-0.3	-1.0	1.0
Intermittent access total infusions	0.5	0.6	1.1	-0.4	0.0	-1.0	1.1
Intermittent access day 1 locomotion	0.0	0.0	0.2	0.1	-0.0	-0.4	-0.1
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.2	-0.5	0.4	-0.6
Intermittent access total locomotion	0.4	0.5	0.9	-0.8	-1.0	-0.6	0.3
Intermittent access standard deviation	0.3	1.8	2.7	-1.6	-1.6	-1.1	1.0
Left kidney weight	0.1	0.5	1.6	0.6	1.3	0.1	0.4
Right kidney weight	0.1	0.6	1.7	-0.2	-0.0	1.3	-0.8
Cocaine induced anxiety	0.6	1.7	3.0	1.5	1.7	1.2	-0.1
Post-drug Anxiety	0.3	0.3	0.6	0.6	0.8	0.2	0.6
Baseline Anxiety	0.5	0.8	1.9	-1.0	-1.4	-0.7	0.2
Tail length	0.1	0.6	1.5	0.9	1.2	-0.0	0.3
Length with tail	1.1	4.7	8.1	2.7	2.8	1.6	-1.0
Length without tail	1.2	6.3	9.9	3.1	2.8	2.0	-1.8
Times rat made contact with spout	0.4	0.4	0.8	-0.4	-0.9	0.4	-0.7
Lifetime Intake	0.7	0.8	1.4	-0.8	-0.2	-1.1	1.2
Liver weight, left	0.5	0.9	1.5	0.9	0.6	1.1	-1.2
Liver weight, right	0.5	0.9	1.7	-1.3	-0.4	-0.5	1.1
Locomotor activity	0.8	1.3	2.3	-0.7	-1.0	1.2	-1.5
Locomotor testing distance	0.7	1.8	3.9	-1.7	-2.0	-0.1	-0.4
Locomotor testing rearing	1.7	6.1	10.2	-3.2	-3.0	-2.0	1.2
Locomotion in novel chamber	2.1	2.9	6.0	-2.5	-2.3	-0.2	0.3
Locomotion in novel chamber post-restriction	0.3	0.9	1.5	-0.4	-0.9	1.2	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.5	0.9	1.0	0.6	0.6	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.4	-0.3	-0.2	-0.0
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.2	-0.4	-0.2	-1.1	0.7
Bouts of movement, locomotor time 1	0.2	0.3	0.6	0.5	0.3	0.8	-0.3
Total resting periods, locomotor time 1	0.7	0.8	1.4	1.0	0.6	1.2	-0.7
Rest time, locomotor task time 1	0.3	0.5	1.4	0.4	-0.1	0.7	-1.2
Distance moved, locomotor task time 1	0.1	0.4	1.1	-0.5	0.2	-0.4	1.1
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.4	0.6	0.1	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.7	1.2	-0.8	-1.1	0.1	-0.9
Bouts of movement, locomotor time 2	0.2	0.5	0.7	-0.9	-0.8	-0.8	0.2
Total resting periods, locomotor time 2	0.1	0.5	0.8	-0.7	-0.6	-0.9	0.4
Rest time, locomotor task time 2	0.3	0.6	0.9	1.0	0.9	0.6	-0.5
Distance moved, locomotor task time 2	0.1	0.2	0.5	0.2	0.7	0.4	0.1
Vertical activity count, locomotor time 2	0.1	0.3	0.8	0.6	0.9	0.1	0.2
Light reinforcement 1	0.6	2.5	5.1	-2.2	-2.2	-0.6	-0.1
Light reinforcement 2	0.2	0.5	0.7	-0.7	-0.6	0.9	-0.7
Bone: marrow area	2.1	5.2	6.0	2.4	2.0	2.3	-2.3
Bone: maximum diameter	0.2	0.4	0.9	-0.0	-0.3	0.8	-1.0
Bone: maximum force	0.4	0.8	1.7	0.3	0.3	1.1	-1.3
Bone: maximum moment	0.4	0.8	1.5	0.5	0.5	1.1	-1.2
Mean time between licks in bursts	0.4	2.3	4.2	2.0	1.5	0.8	-1.4
Mean num. licks in bursts	0.3	0.8	2.0	-0.5	-0.1	-1.0	1.4
Cd content in liver	0.9	1.0	1.9	1.4	1.3	0.5	0.1
Co content in liver	1.3	1.5	2.6	1.3	1.6	-0.6	1.1
Cu content in liver	0.7	0.8	1.9	-0.5	-0.2	-1.0	1.4
Fe content in liver	1.3	1.6	2.1	1.4	1.5	1.3	-0.9
K content in liver	1.6	1.5	3.0	-1.7	-1.1	-0.9	1.1
Mg content in liver	3.1	3.4	5.8	-1.7	-0.8	-2.1	2.4
Mn content in liver	1.9	2.1	3.1	-1.5	-1.2	-1.8	1.2
Na content in liver	1.1	1.2	2.6	-0.7	-0.7	1.6	-1.2
Rb content in liver	0.8	1.0	1.2	-1.1	-1.1	-1.0	0.6
Se content in liver	5.8	6.8	12.4	-3.5	-3.1	-1.6	1.5
Sr content in liver	1.0	0.8	2.0	-0.1	0.2	-1.4	1.2
Zn content in liver	2.8	3.3	5.9	-2.4	-2.0	-1.0	1.4
Bone: minimum diameter	0.5	1.0	1.1	1.0	1.0	1.0	-1.0
Time in familiar zone, hab. session 1	1.2	1.4	2.9	-0.2	-0.3	1.7	-1.5
Time in novel zone, hab. session 1	1.9	2.1	4.2	-0.7	-0.6	-2.1	1.9
Total zone transitions, hab. session 1	0.8	1.2	2.6	1.4	1.6	0.1	0.4
Total locomotion distance, hab. session 1	0.3	0.4	1.0	-0.2	0.2	-0.7	1.0
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.1	0.6	-0.3	0.8
Time in familiar zone, hab. session 2	0.4	0.5	0.9	-1.0	-0.7	0.6	0.0
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.2	-0.4	-0.8	0.1
Total zone transitions, hab. session 2	0.9	1.1	2.0	1.4	1.3	0.6	-0.6
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.8	0.6	0.8	-0.7
Locomotion velocity, hab. session 2	0.5	0.7	0.9	1.0	0.8	0.8	-0.6
Novel to familiar place preference ratio	0.4	0.5	1.1	0.4	0.9	-0.5	1.0
Novelty place preference	0.6	0.8	1.6	0.3	0.8	-0.8	1.3
Time in novel zone, NPP test	0.5	0.6	1.5	-0.0	0.4	-0.8	1.2
Total zone transitions, NPP test	1.5	2.3	3.7	1.5	0.9	1.5	-1.9
Total locomotion distance, NPP test	0.6	0.8	1.8	0.6	0.4	1.0	-1.3
Locomotion velocity, NPP test	0.7	1.0	1.2	1.1	0.9	0.9	-1.1
Intraocular pressure	1.7	2.9	6.2	2.5	2.2	0.7	0.1
Delta distance traveled before/after self-admin	0.8	0.8	1.6	1.0	1.3	-0.3	0.8
Delta ambulatory time before/after self-admin	0.5	0.9	1.8	1.3	1.4	0.5	-0.0
Parametrial fat weight	0.6	1.5	1.9	-0.9	-1.3	1.4	-1.2
Pavlov. Cond. lever latency	1.7	2.1	3.1	1.2	1.7	-1.3	1.6
Pavlov. Cond. magazine entry latency	4.8	6.1	12.6	-3.4	-3.6	0.3	-0.6
Pavlov. Cond. change in total contacts	5.6	6.0	11.0	-3.3	-3.0	-1.5	1.2
Pavlov. Cond. index score	3.9	5.0	10.6	-2.8	-3.3	0.6	-1.1
Pavlov. Cond. latency score	3.2	4.0	8.1	-2.4	-2.9	0.9	-1.3
Pavlov. Cond. lever contacts	2.1	2.6	4.0	-1.3	-2.0	1.3	-1.7
Pavlov. Cond. magazine entry number	5.8	7.4	14.9	3.8	3.9	0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.4	1.1	1.2	-0.5	0.7
Pavlov. Cond. lever-magazine prob. diff.	4.6	5.7	12.3	-3.1	-3.5	0.4	-1.0
Pavlov. Cond. response bias	4.8	6.0	12.4	-3.4	-3.5	-0.2	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.7	0.9	-0.3	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	0.1	0.5	-0.4
Pavlov. Cond. change in total contacts	0.2	0.4	0.9	-0.7	-0.9	-0.6	-0.0
Pavlov. Cond. index score	0.1	0.2	0.5	-0.1	-0.5	0.4	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.5	-0.0	-0.3	0.5	-0.7
Pavlov. Cond. lever contacts	0.3	0.5	0.8	-0.6	-0.9	0.5	-0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.3	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	0.6	1.4	1.9	1.0	1.4	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.0	-0.3	0.4	-0.6
Pavlov. Cond. response bias	0.6	0.8	1.5	-1.0	-1.2	0.5	-0.7
Time in closed arm before self-admin	1.3	2.2	3.6	-1.5	-1.3	-1.9	1.1
Time in closed arm after self-admin	1.2	1.4	3.2	-0.1	0.4	-1.8	1.5
Time in open arm before self-admin	0.9	1.1	1.2	1.0	1.0	1.1	-0.9
Time in open arm after self-admin	0.1	0.1	0.2	0.4	0.5	0.4	0.0
Bone: periosteal estimation	0.7	1.7	2.9	1.0	0.7	1.6	-1.7
Bone: periosteal perimeter	1.2	2.4	3.5	1.4	1.1	1.7	-1.9
Bone: post-yield work	0.7	1.1	2.1	1.4	1.4	0.3	-0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	-0.1	-0.4	0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.3	-0.0	-0.4	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.6	0.8	-0.8	-0.5	-0.9	0.8
Progressive ratio test 2 active lever presses	0.4	0.6	1.2	-0.9	-1.1	-0.5	0.1
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	-1.0	-1.1	-0.4	0.0
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.4	-0.4	-0.4	0.3
Incentive Sensitization - Responses	0.3	0.9	2.1	-0.9	-1.5	0.0	-0.7
Incentive Sensitization - Breakpoint	0.3	0.8	1.9	-0.8	-1.4	0.1	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.5	-0.1	0.5	-0.1
Progressive ratio	0.1	0.3	0.4	-0.4	-0.5	0.7	-0.6
Food seeking constrained by brief footshock	0.3	0.4	0.5	-0.7	-0.7	0.4	-0.5
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.1	0.3	-0.5	0.5
Retroperitoneal fat weight	0.0	0.1	0.1	-0.4	-0.3	0.0	-0.3
Reaction time number correct	0.3	1.1	1.4	1.2	1.0	0.8	-1.1
Reaction time mean minus median	0.1	0.3	1.0	1.0	0.6	0.0	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.2	0.4	0.1	-0.0	-0.0
Reaction time num false alarms	0.6	1.1	2.8	-0.3	-0.8	0.9	-1.7
Reaction time num false alarms AUC	0.6	1.4	4.0	-0.1	-0.7	1.1	-2.0
Reaction time trials correct on left	0.3	1.1	1.4	1.2	1.0	0.8	-1.1
Reaction time trials on left	0.3	1.0	1.4	1.2	1.0	0.8	-1.1
Reaction time mean	0.5	1.1	1.8	-0.9	-0.7	-1.1	1.4
Reaction time mean AUC	0.5	1.3	2.2	-1.0	-0.7	-1.2	1.5
Median of all reaction times	1.4	2.3	2.7	-1.6	-1.3	-1.4	1.6
Reaction time omissions	0.2	0.4	0.6	-0.8	-0.8	-0.4	0.3
Reaction time false alarm rate	0.6	0.9	1.4	-0.7	-1.1	0.5	-1.2
Reaction time premature initiation rate	0.6	0.9	2.0	-1.4	-1.0	0.2	0.8
Reaction time premature initiations	0.0	0.1	0.2	-0.4	-0.1	0.5	0.2
Std. dev. reaction times	0.0	0.0	0.1	0.1	-0.1	-0.1	0.2
Reaction time trials completed	0.3	1.0	1.4	1.2	1.0	0.8	-1.1
Reaction time trials AUC	0.3	0.9	1.4	1.2	0.9	0.6	-1.0
Run reversals in cocaine runway, females	2.1	2.3	3.7	0.5	1.6	-1.7	1.9
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.5
Latency to leave start box in cocaine runway	0.7	0.9	2.0	1.2	1.4	-0.4	0.1
Latency to leave start box in cocaine runway, F	0.9	1.1	2.6	1.2	1.6	0.2	0.2
Latency to leave start box in cocaine runway, M	0.3	0.3	1.1	-0.2	-0.2	-1.0	0.2
Std. dev. time between licks in bursts	0.3	0.6	1.5	0.6	0.1	0.7	-1.2
Total sessions with >9 infusions	1.4	1.8	3.7	-0.8	-0.3	-1.9	1.6
Short access day 1 total inactive lever presses	0.7	1.5	2.4	-1.6	-1.2	-1.1	1.0
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.1
Short access day 1 total infusions	1.2	2.4	4.1	-1.3	-0.3	-1.9	2.0
Short access day 10 total infusions	0.3	0.5	0.7	-0.8	-0.5	-0.8	0.6
Short access total infusions	0.8	1.2	1.7	-1.1	-0.4	-1.2	1.3
Short access day 1 locomotion	0.9	1.4	2.1	-1.4	-0.8	-1.4	1.0
Short access day 10 total locomotion	0.2	0.7	1.8	-0.9	-1.3	-0.0	-0.6
Short access total locomotion	0.2	0.2	0.6	-0.4	-0.3	-0.8	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	0.4	-0.4	0.3
Compulsive drug intake	1.6	2.4	5.6	0.2	0.3	-2.4	2.0
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	-0.0	0.3	-0.0
Social response proportion	0.2	0.3	0.7	0.5	0.9	0.1	0.1
Social responses	0.2	0.3	0.7	0.0	-0.1	0.7	-0.8
Social time	1.2	1.9	3.7	0.7	0.0	1.9	-1.8
Soleus weight	1.0	2.9	6.0	0.7	0.1	2.2	-2.5
Bone: stiffness	0.1	0.2	0.4	-0.2	0.1	0.6	-0.6
Tibialis anterior weight	0.9	3.2	5.4	2.2	2.3	1.5	-0.6
Time to tail flick, vehicle, before self-admin	0.4	0.5	1.1	0.7	-0.1	0.6	-1.1
Time to tail flick, vehicle, after self-admin	0.5	1.0	1.9	0.2	-0.5	1.4	-1.3
Time to tail flick, test, before self-admin	0.6	0.6	1.0	1.0	0.8	0.9	-0.3
Time to tail flick, test, after self-admin	0.9	0.9	2.1	0.5	-0.1	1.1	-1.5
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	3.2	-0.4	-0.8	1.8	-1.5
Delta time to tail flick, test, before/after SA	0.6	0.8	1.7	-1.0	-1.3	-0.2	-0.6
Tibia length	1.5	4.3	5.3	2.2	2.3	2.2	-1.4
Ambulatory time before self-admin	0.0	0.1	0.1	-0.3	-0.2	0.3	-0.0
Ambulatory time after self-admin	0.6	1.0	1.5	1.1	1.2	1.1	-0.2
Bone: tissue strength	1.0	1.1	2.4	1.5	1.3	0.0	-0.6
Total heroin consumption	2.4	2.9	3.7	-1.5	-1.8	1.6	-1.9
Bone: trabecular number	2.4	4.5	9.0	-2.8	-3.0	0.5	-1.0
Bone: trabecular spacing	1.6	2.3	3.1	1.8	1.5	1.7	-1.1
Bone: trabecular thickness	0.1	0.1	0.4	-0.0	-0.3	0.2	-0.7
Bone: trabecular tissue density	1.2	2.1	4.3	-0.3	0.3	-2.1	2.0
Water consumed over 24 hours	0.3	0.5	1.0	0.8	0.4	0.5	-1.0
Number of responses in last shaping day	1.2	1.5	3.5	-0.5	-0.4	-1.9	1.5