Hub : Genes

LOC134480866

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr10_83480463_83481899	0.1	0.07	1.8e-12	0.09	0.1	0.09	0.09	1.7e-10	1.6e-11	1.7e-10	2.1e-10
2	Liver	intron excision ratio	chr10_83480463_83481888	0.11	0.08	1.8e-13	0.11	0.12	0.1	0.1	3.4e-12	1.1e-12	4.0e-11	2.1e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.9	3.5	3.6	-1.9	1.8
Area under the delay curve	0.8	1.2	1.3	-1.1	1.1
BMI with tail	2.0	6.8	7.0	2.6	-2.6
BMI without tail	0.9	5.0	5.1	2.2	-2.2
Body weight	7.8	34.2	34.3	5.9	-5.8
Weight adjusted by age	0.0	0.1	0.2	0.4	-0.4
Bone surface	0.0	0.0	0.0	-0.0	-0.0
Bone volume	0.1	0.1	0.2	-0.4	0.3
Breakpoint value in progressive ratio session	1.2	2.2	2.3	1.5	-1.5
Number of licking bursts	0.2	0.6	0.6	-0.8	0.8
Context. condit. distance diff. score	0.4	0.5	0.6	0.8	-0.7
Locomotion velocity, session 1	1.0	1.1	1.2	1.0	-1.1
Locomotion distance, session 1	4.0	5.1	5.2	2.2	-2.3
Locomotion velocity, session 2	0.7	0.8	0.9	0.9	-0.9
Locomotion distance, session 2	1.0	1.4	1.5	1.1	-1.2
Locomotion velocity, session 3	0.1	0.2	0.2	0.4	-0.4
Locomotion distance, session 3	0.5	0.6	0.6	0.7	-0.8
Stereotopy head waving bouts, day 3	3.7	4.4	4.4	-2.1	2.1
Stereotopy head waving duration, day 3	0.6	0.8	0.8	-0.9	0.9
Locomotion velocity, session 7	0.8	0.9	0.9	1.0	-0.9
Locomotion distance, session 7	0.1	0.1	0.1	0.4	-0.3
Stereotopy head waving bouts, day 7	1.4	1.6	1.6	-1.3	1.2
Stereotopy head waving duration, day 7	0.3	0.4	0.4	-0.6	0.6
Locomotion velocity, session 8	7.1	8.6	8.7	3.0	-2.9
Locomotion distance, session 8	1.8	2.6	2.6	1.6	-1.6
Degree of sensitization distance	0.2	0.2	0.3	0.5	-0.4
Degree of sensitization stereotypy	1.8	2.0	2.0	-1.4	1.4
Conditioned locomotion	0.2	0.2	0.2	-0.5	0.5
Cocaine response after cond. corrected	1.8	2.6	2.7	-1.6	1.6
Cocaine response after cond. not corrected	2.7	3.8	3.9	-2.0	2.0
Cocaine response before conditioning	0.6	0.7	0.8	-0.8	0.9
Saline control response	0.0	0.0	0.0	-0.1	0.1
Bone: connectivity density	2.8	4.5	4.7	-2.2	2.1
Bone: cortical apparent density	4.5	7.1	7.3	-2.7	2.6
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5
Bone: cortical porosity	0.9	1.0	1.0	-1.0	1.0
Bone: cortical porosity	0.9	0.9	1.0	-0.9	1.0
Bone: cortical thickness	1.5	2.5	2.5	-1.6	1.6
Bone: cortical thickness	4.7	5.7	5.8	-2.4	2.4
Bone: cortical tissue density	4.5	7.1	7.2	-2.7	2.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.5	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.8	0.8	0.8	-0.9	0.9
Condit. Reinf. active responses	0.6	0.8	0.9	-0.9	0.9
Condit. Reinf. inactive responses	0.4	0.5	0.5	-0.7	0.7
Incentive salience index mean	1.3	1.7	1.7	-1.3	1.3
Condit. Reinf. lever presses	1.2	1.8	1.8	-1.3	1.3
Condit. Reinf. active minus inactive responses	0.5	0.7	0.7	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	-0.7	0.6
Condit. Reinf. active responses	0.9	1.3	1.3	-1.1	1.1
Condit. Reinf. inactive responses	1.5	2.2	2.2	-1.5	1.5
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. lever reinforcers received	0.9	1.2	1.2	-1.1	1.1
Conditioned reinforcement - actives	0.2	0.8	0.9	-0.8	0.9
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1
Conditioned locomotion	1.2	1.8	1.8	-1.3	1.4
Patch foraging indifference point 0 sec	0.8	2.3	2.4	-1.5	1.5
Patch foraging indifference point AUC	0.0	0.0	0.0	0.0	-0.1
Delay disc. indifference point, 0s delay	2.1	2.3	2.3	-1.5	1.5
Delay disc. indifference point, 16s delay	0.5	0.7	0.7	-0.9	0.9
Delay disc. indifference point, 2s delay	2.7	3.0	3.0	-1.7	1.7
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.2	0.2
Delay disc. indifference point, 4s delay	0.8	0.9	0.9	-0.9	0.9
Delay disc. indifference point, 8s delay	0.4	0.7	0.7	-0.8	0.9
Indifference point function ln k	0.0	0.0	0.0	-0.1	0.1
Indifference point function log k	0.0	0.0	0.0	-0.1	0.1
Patch foraging total patch changes 0 sec	0.5	1.4	1.5	-1.2	1.2
Patch foraging total patch changes 12 sec	4.2	5.6	5.7	-2.4	2.3
Patch foraging total patch changes 18 sec	0.1	0.3	0.3	-0.5	0.5
Patch foraging total patch changes 24 sec	0.6	2.1	2.2	-1.5	1.4
Patch foraging total patch changes 6 sec	1.0	1.6	1.8	-1.3	1.2
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 12 sec	0.1	0.5	0.5	0.7	-0.7
Patch foraging water rate 18 sec	0.3	0.7	0.7	-0.8	0.8
Patch foraging water rate 24 sec	0.2	0.3	0.4	-0.6	0.6
Patch foraging water rate 6 sec	0.9	1.3	1.3	-1.1	1.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.2	0.4	-0.4
Distance traveled before self-admin	0.1	0.2	0.2	0.5	-0.4
Distance traveled after self-admin	0.6	1.1	1.2	1.1	-1.0
Extensor digitorum longus weight	8.7	34.7	35.1	5.9	-5.9
Bone: elastic displacement	0.0	0.0	0.0	-0.2	0.2
Bone: elastic work	0.0	0.0	0.0	-0.1	0.1
Bone: endosteal estimation	1.8	4.4	4.5	2.1	-2.1
Bone: endosteal perimeter	1.7	4.2	4.3	2.1	-2.0
Epididymis fat weight	0.0	0.2	0.2	0.5	-0.5
Delta time in closed arm before/after self-admin	4.3	4.0	4.0	2.0	-2.0
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.2	0.5	-0.4
Delay discount exponential model param	0.6	0.8	0.8	0.9	-0.9
Extinction: sum of active levers before priming	0.4	0.6	0.6	0.8	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	0.1
Bone: final force	1.2	1.9	2.0	-1.4	1.4
Bone: final moment	1.0	1.6	1.6	-1.2	1.3
Food consumed during 24 hour testing period	0.6	1.2	1.2	1.1	-1.1
Glucose	0.5	0.9	0.9	-0.9	0.9
Heart weight	3.3	5.2	5.3	2.3	-2.3
Delay discount hyperbolic model param	0.5	0.7	0.7	0.8	-0.9
Intermittent access intake day 1-15 change	0.0	0.2	0.2	0.5	-0.5
Intermittent access intake escalation	0.0	0.2	0.2	0.5	-0.5
Intermittent access intake escalation 2	0.5	0.8	0.8	0.9	-0.9
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.5	-0.7	0.7
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.1	-1.0	1.0
Intermitt. access escalation Index	0.4	1.4	1.4	1.2	-1.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	0.0
Intermittent access day 15 total infusions	0.1	0.2	0.2	0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.0	-0.0
Intermittent access total infusions	0.1	0.1	0.1	0.4	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.4	0.4
Intermittent access day 15 total locomotion	0.2	0.7	0.8	-0.8	0.9
Intermittent access total locomotion	1.1	1.4	1.4	-1.1	1.2
Intermittent access standard deviation	0.0	0.1	0.1	-0.3	0.2
Left kidney weight	0.7	5.5	5.6	2.3	-2.4
Right kidney weight	0.1	0.6	0.6	0.7	-0.8
Cocaine induced anxiety	1.9	5.2	5.2	2.3	-2.3
Post-drug Anxiety	1.0	1.2	1.2	1.1	-1.1
Baseline Anxiety	2.5	4.2	4.3	-2.0	2.1
Tail length	1.1	6.2	6.3	2.4	-2.5
Length with tail	4.8	21.1	21.3	4.6	-4.6
Length without tail	2.1	11.2	11.2	3.4	-3.3
Times rat made contact with spout	1.0	1.1	1.2	-1.1	1.0
Lifetime Intake	0.0	0.0	0.0	0.2	-0.2
Liver weight, left	0.1	0.2	0.2	0.5	-0.5
Liver weight, right	0.3	0.5	0.6	-0.8	0.7
Locomotor activity	0.6	0.9	0.9	-1.0	1.0
Locomotor testing distance	2.0	4.9	5.0	-2.2	2.2
Locomotor testing rearing	2.2	8.1	8.3	-2.9	2.8
Locomotion in novel chamber	4.0	5.3	5.6	-2.4	2.3
Locomotion in novel chamber post-restriction	0.1	0.2	0.2	-0.5	0.4
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	0.4	-0.4
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.6	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.8	0.8	-0.9	0.9
Bouts of movement, locomotor time 1	0.4	0.6	0.6	0.8	-0.7
Total resting periods, locomotor time 1	0.7	0.8	0.8	0.9	-0.9
Rest time, locomotor task time 1	0.0	0.0	0.0	0.2	-0.2
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.3	0.4
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.3	-0.2
Time >=10cm from walls, locomotor time 2	0.7	2.0	2.1	-1.4	1.5
Bouts of movement, locomotor time 2	0.0	0.1	0.1	-0.3	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	0.1
Rest time, locomotor task time 2	0.8	1.3	1.3	1.1	-1.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	-0.2
Light reinforcement 1	0.6	2.8	2.8	-1.7	1.6
Light reinforcement 2	0.4	0.8	0.9	-0.9	0.9
Bone: marrow area	1.7	4.2	4.3	2.1	-2.0
Bone: maximum diameter	0.0	0.0	0.0	0.0	0.0
Bone: maximum force	0.0	0.0	0.0	-0.1	0.1
Bone: maximum moment	0.0	0.0	0.0	0.0	0.0
Mean time between licks in bursts	0.4	2.6	2.6	1.6	-1.6
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	0.1
Cd content in liver	1.3	1.5	1.5	1.2	-1.2
Co content in liver	2.3	2.7	2.8	1.7	-1.6
Cu content in liver	0.6	0.7	0.8	0.8	-0.9
Fe content in liver	2.1	2.6	2.6	1.6	-1.6
K content in liver	0.0	0.0	0.1	-0.2	0.2
Mg content in liver	0.1	0.1	0.1	-0.4	0.3
Mn content in liver	0.1	0.1	0.1	-0.4	0.3
Na content in liver	0.1	0.2	0.2	-0.4	0.4
Rb content in liver	1.6	1.9	1.9	-1.4	1.3
Se content in liver	3.7	4.4	4.6	-2.1	2.0
Sr content in liver	1.1	1.0	1.0	1.0	-1.0
Zn content in liver	1.7	2.0	2.1	-1.4	1.4
Bone: minimum diameter	0.5	0.9	0.9	1.0	-0.9
Time in familiar zone, hab. session 1	0.4	0.4	0.4	-0.6	0.7
Time in novel zone, hab. session 1	0.6	0.7	0.7	-0.8	0.8
Total zone transitions, hab. session 1	2.4	3.3	3.4	1.8	-1.8
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.2	-0.2
Locomotion velocity, hab. session 1	0.6	0.9	0.9	0.9	-0.9
Time in familiar zone, hab. session 2	0.5	0.6	0.6	-0.8	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.2	0.1
Total zone transitions, hab. session 2	0.7	0.8	0.9	0.9	-0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.4	-0.4
Locomotion velocity, hab. session 2	0.3	0.4	0.4	0.7	-0.6
Novel to familiar place preference ratio	1.3	1.6	1.7	1.3	-1.3
Novelty place preference	0.8	1.0	1.0	1.0	-1.0
Time in novel zone, NPP test	0.2	0.3	0.3	0.5	-0.5
Total zone transitions, NPP test	0.3	0.5	0.5	0.7	-0.7
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.0	0.0
Locomotion velocity, NPP test	0.3	0.4	0.4	0.6	-0.7
Intraocular pressure	1.4	2.3	2.4	1.5	-1.5
Delta distance traveled before/after self-admin	0.7	0.7	0.8	0.9	-0.8
Delta ambulatory time before/after self-admin	0.2	0.3	0.3	0.6	-0.5
Parametrial fat weight	0.4	0.9	0.9	-0.9	1.0
Pavlov. Cond. lever latency	2.8	3.5	3.5	1.9	-1.9
Pavlov. Cond. magazine entry latency	10.2	13.1	13.3	-3.6	3.6
Pavlov. Cond. change in total contacts	9.4	10.2	10.4	-3.2	3.2
Pavlov. Cond. index score	9.7	12.3	12.4	-3.5	3.5
Pavlov. Cond. latency score	7.6	9.6	9.7	-3.1	3.1
Pavlov. Cond. lever contacts	3.5	4.2	4.2	-2.1	2.0
Pavlov. Cond. magazine entry number	14.8	18.8	19.0	4.4	-4.3
Pavlov. Cond. intertrial magazine entries	1.5	1.8	1.8	1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	11.4	14.1	14.2	-3.8	3.7
Pavlov. Cond. response bias	11.2	13.9	14.1	-3.8	3.7
Pavlov. Cond. lever latency	0.3	0.4	0.4	0.6	-0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. change in total contacts	0.2	0.6	0.6	-0.8	0.7
Pavlov. Cond. index score	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	0.4
Pavlov. Cond. lever contacts	0.4	0.6	0.6	-0.8	0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	1.1	2.4	2.5	1.6	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	-0.3	0.2
Pavlov. Cond. response bias	0.8	1.0	1.1	-1.0	1.0
Time in closed arm before self-admin	1.2	2.1	2.2	-1.5	1.4
Time in closed arm after self-admin	0.3	0.4	0.4	0.6	-0.6
Time in open arm before self-admin	2.3	2.9	2.9	1.7	-1.7
Time in open arm after self-admin	0.4	0.4	0.4	0.6	-0.6
Bone: periosteal estimation	0.2	0.4	0.4	0.6	-0.6
Bone: periosteal perimeter	0.6	1.2	1.3	1.1	-1.1
Bone: post-yield work	0.7	1.2	1.2	1.1	-1.1
Progressive ratio test 1 active lever presses	0.2	0.4	0.4	-0.6	0.7
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	-0.5	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.5	-0.7	0.7
Progressive ratio test 2 breakpoint	0.5	0.6	0.6	-0.8	0.8
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.3	-0.3
Incentive Sensitization - Responses	0.3	0.8	0.8	-0.9	0.9
Incentive Sensitization - Breakpoint	0.3	0.6	0.6	-0.8	0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	-0.4	0.4
Progressive ratio	0.0	0.0	0.0	0.1	-0.1
Food seeking constrained by brief footshock	0.4	0.5	0.5	-0.7	0.7
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	-0.5	0.5
Retroperitoneal fat weight	0.1	0.4	0.4	-0.6	0.7
Reaction time number correct	0.3	1.2	1.2	1.1	-1.1
Reaction time mean minus median	0.0	0.1	0.1	0.3	-0.3
Reaction time mean minus median AUC	0.0	0.3	0.4	-0.6	0.6
Reaction time num false alarms	0.5	0.9	0.9	-0.9	0.9
Reaction time num false alarms AUC	0.3	0.6	0.6	-0.8	0.8
Reaction time trials correct on left	0.3	1.2	1.2	1.1	-1.1
Reaction time trials on left	0.3	1.1	1.2	1.1	-1.0
Reaction time mean	0.0	0.0	0.0	-0.1	0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.1	0.0
Median of all reaction times	0.2	0.3	0.3	-0.6	0.5
Reaction time omissions	0.2	0.4	0.4	-0.6	0.6
Reaction time false alarm rate	1.2	1.6	1.6	-1.3	1.3
Reaction time premature initiation rate	0.2	0.3	0.3	-0.5	0.5
Reaction time premature initiations	0.0	0.1	0.1	0.4	-0.3
Std. dev. reaction times	0.0	0.0	0.0	-0.1	0.1
Reaction time trials completed	0.3	1.1	1.2	1.1	-1.0
Reaction time trials AUC	0.3	0.9	1.0	1.0	-1.0
Run reversals in cocaine runway, females	1.4	1.6	1.7	1.3	-1.2
Run reversals in cocaine runway, males	0.3	0.3	0.3	-0.5	0.5
Latency to leave start box in cocaine runway	2.2	3.1	3.1	1.7	-1.8
Latency to leave start box in cocaine runway, F	3.0	3.8	3.8	1.9	-1.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.3	-0.4
Std. dev. time between licks in bursts	0.2	0.3	0.3	0.6	-0.6
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	0.1
Short access day 1 total inactive lever presses	0.6	1.1	1.2	-1.1	1.0
Short access day 10 total inactive lever presses	0.1	0.7	0.7	0.8	-0.9
Short access day 1 total infusions	0.0	0.0	0.0	-0.2	0.2
Short access day 10 total infusions	0.1	0.2	0.2	-0.5	0.5
Short access total infusions	0.0	0.0	0.0	0.0	-0.0
Short access day 1 locomotion	0.5	0.8	0.8	-0.9	0.9
Short access day 10 total locomotion	0.9	3.6	3.6	-1.9	1.9
Short access total locomotion	0.2	0.3	0.3	-0.5	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.2	-0.1
Compulsive drug intake	0.1	0.1	0.1	-0.3	0.3
One hour access (shock baseline)	0.1	0.2	0.2	0.4	-0.4
Social response proportion	0.0	0.0	0.0	-0.0	0.1
Social responses	0.1	0.1	0.1	-0.4	0.3
Social time	0.0	0.0	0.0	0.0	-0.1
Soleus weight	0.5	1.3	1.4	-1.1	1.2
Bone: stiffness	0.0	0.0	0.0	-0.1	0.1
Tibialis anterior weight	1.3	4.5	4.5	2.1	-2.1
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.3	-0.5	0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.2	0.2
Time to tail flick, test, before self-admin	0.4	0.5	0.5	0.7	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.4	-0.6	0.6
Delta time to tail flick, test, before/after SA	1.9	2.3	2.4	-1.5	1.5
Tibia length	0.7	2.0	2.1	1.4	-1.4
Ambulatory time before self-admin	0.2	0.6	0.6	0.8	-0.8
Ambulatory time after self-admin	1.8	2.8	2.9	1.7	-1.7
Bone: tissue strength	0.5	0.5	0.5	0.7	-0.7
Total heroin consumption	0.6	0.7	0.7	-0.9	0.8
Bone: trabecular number	4.9	9.1	9.3	-3.0	3.0
Bone: trabecular spacing	1.0	1.5	1.5	1.2	-1.2
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	0.1
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	-0.1
Water consumed over 24 hours	0.0	0.0	0.0	0.1	-0.1
Number of responses in last shaping day	0.0	0.0	0.1	0.2	-0.3