Hub : Genes

LOC134480722

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression LOC134480722 0.31 0.12 1.9e-04 0.01 0.17 0.11 0.08 1.7e-01 8.4e-05 1.3e-03 5.1e-03
2 BLA gene expression LOC134480722 0.71 0.08 0.0e+00 0.4 0.39 0.41 0.42 7.6e-23 9.6e-22 1.3e-23 3.8e-24
3 PL gene expression LOC134480722 0.68 0.08 0.0e+00 0.45 0.44 0.44 0.3 5.4e-54 6.0e-53 5.2e-53 8.0e-33
4 IL gene expression LOC134480722 0.72 0.09 8.9e-13 0.38 0.36 0.35 0.38 3.0e-10 1.4e-09 3.8e-09 5.4e-10
5 NAcc gene expression LOC134480722 0.13 0.05 1.7e-16 0.12 0.12 0.13 0.04 2.8e-18 6.2e-18 1.0e-19 5.3e-07
6 OFC gene expression LOC134480722 0.3 0.12 1.2e-03 0.06 0.03 0.02 0.06 1.8e-02 7.6e-02 1.1e-01 2.0e-02
7 Brain gene expression LOC134480722 0.44 0.1 0.0e+00 0.37 0.33 0.36 0.17 2.5e-36 6.2e-32 2.9e-35 1.2e-15
8 IC gene expression LOC134480722 0.39 0.12 7.1e-11 0.29 0.23 0.24 0.13 1.3e-12 4.6e-10 1.8e-10 4.1e-06
9 pVTA gene expression LOC134480722 0.22 0.08 1.9e-14 0.16 0.18 0.17 0.15 1.3e-12 2.7e-14 7.1e-14 4.8e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.3-0.50.0-0.10.10.1-0.10.10.0-0.2
Area under the delay curve0.80.91.2-0.30.91.11.01.11.11.00.91.0
BMI with tail0.10.52.11.0-0.3-0.2-0.1-0.7-0.2-0.1-0.5-1.4
BMI without tail0.10.32.01.40.20.20.20.40.20.2-0.1-0.1
Body weight0.10.31.01.00.60.30.40.80.30.3-0.10.3
Weight adjusted by age0.20.40.80.90.40.70.60.70.70.40.50.3
Bone surface3.56.416.0-4.0-2.4-2.5-2.3-2.2-2.4-2.3-2.5-1.7
Bone volume2.03.59.4-3.1-1.8-1.8-1.7-1.6-1.8-1.7-1.8-1.2
Breakpoint value in progressive ratio session2.22.73.21.11.71.61.71.81.61.61.61.8
Number of licking bursts1.21.95.3-2.3-1.2-1.3-1.3-1.4-1.3-1.2-1.0-0.8
Context. condit. distance diff. score0.20.21.11.10.30.40.30.30.40.30.70.1
Locomotion velocity, session 10.10.10.2-0.4-0.1-0.1-0.30.2-0.2-0.3-0.20.4
Locomotion distance, session 10.10.21.01.00.2-0.1-0.20.6-0.2-0.2-0.10.3
Locomotion velocity, session 20.91.11.6-0.6-1.0-1.2-1.3-0.7-1.2-1.2-1.0-0.8
Locomotion distance, session 21.11.62.6-0.1-1.1-1.6-1.5-0.6-1.6-1.5-1.5-0.8
Locomotion velocity, session 30.40.51.81.30.50.40.30.80.30.30.60.8
Locomotion distance, session 31.31.52.1-0.1-1.2-1.3-1.4-1.0-1.3-1.4-1.5-1.1
Stereotopy head waving bouts, day 31.61.82.51.41.21.51.41.01.51.41.61.1
Stereotopy head waving duration, day 30.00.10.20.3-0.00.10.1-0.20.20.10.40.2
Locomotion velocity, session 72.62.93.9-0.7-1.7-1.9-2.0-1.4-1.9-2.0-1.8-1.4
Locomotion distance, session 74.96.28.3-0.8-2.5-2.7-2.9-2.0-2.7-2.9-2.9-2.4
Stereotopy head waving bouts, day 71.71.93.30.81.31.51.51.21.41.51.81.3
Stereotopy head waving duration, day 70.91.12.40.10.91.21.20.51.11.31.60.8
Locomotion velocity, session 81.31.62.2-0.7-1.3-1.3-1.4-1.2-1.3-1.5-1.4-1.0
Locomotion distance, session 81.31.92.90.2-1.4-1.7-1.7-0.9-1.6-1.7-1.3-1.2
Degree of sensitization distance0.60.60.8-0.4-0.8-0.9-0.9-0.5-0.8-0.9-0.8-0.8
Degree of sensitization stereotypy1.31.42.40.61.21.21.31.01.21.31.51.0
Conditioned locomotion0.10.10.3-0.2-0.3-0.2-0.2-0.5-0.3-0.2-0.1-0.6
Cocaine response after cond. corrected1.41.72.60.71.41.61.51.01.61.51.30.8
Cocaine response after cond. not corrected0.50.60.80.50.90.90.80.70.90.80.70.7
Cocaine response before conditioning1.61.93.0-0.3-1.4-1.7-1.7-0.9-1.7-1.7-1.6-0.6
Saline control response0.10.10.30.40.20.00.00.60.00.10.00.6
Bone: connectivity density0.50.71.8-1.3-0.7-0.8-0.6-0.7-0.8-0.6-0.7-1.1
Bone: cortical apparent density4.25.86.42.52.42.52.42.42.52.42.42.1
Bone: cortical area0.61.01.40.2-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.2
Bone: cortical porosity0.50.51.0-1.0-0.8-0.7-0.7-0.7-0.6-0.7-0.9-0.1
Bone: cortical porosity0.60.61.5-1.2-0.9-0.7-0.7-0.8-0.6-0.7-1.0-0.2
Bone: cortical thickness8.614.335.86.03.63.43.53.63.43.53.43.0
Bone: cortical thickness2.22.65.92.41.51.51.51.51.61.51.41.1
Bone: cortical tissue density4.45.96.72.42.52.62.52.42.62.42.52.1
Condit. Reinf. active minus inactive responses0.10.20.70.7-0.3-0.1-0.1-0.2-0.1-0.2-0.2-0.8
Condit. Reinf. active-inactive response ratio0.30.31.70.3-0.5-0.3-0.2-0.6-0.2-0.3-0.2-1.3
Condit. Reinf. active responses0.20.31.51.20.30.40.40.40.40.30.2-0.2
Condit. Reinf. inactive responses0.30.40.90.90.60.40.41.00.40.40.20.9
Incentive salience index mean0.10.10.50.70.10.20.30.20.20.20.2-0.4
Condit. Reinf. lever presses0.20.30.60.70.50.50.50.80.50.40.40.3
Condit. Reinf. active minus inactive responses0.60.70.9-0.4-0.9-0.9-0.9-0.8-0.9-0.9-0.9-0.7
Condit. Reinf. active-inactive response ratio0.70.91.1-0.6-1.0-0.9-1.0-0.8-1.0-1.1-1.0-0.7
Condit. Reinf. active responses0.70.91.3-0.3-1.0-1.1-1.1-0.8-1.1-1.1-1.1-0.9
Condit. Reinf. inactive responses0.10.10.20.4-0.2-0.4-0.3-0.1-0.3-0.3-0.3-0.2
Condit. Reinf. lever presses2.83.84.6-1.2-2.0-2.2-2.1-1.7-2.1-2.1-2.1-1.8
Condit. Reinf. lever reinforcers received1.21.72.3-0.5-1.3-1.5-1.5-1.1-1.5-1.4-1.4-1.2
Conditioned reinforcement - actives0.30.50.8-0.0-0.8-0.6-0.6-0.8-0.6-0.7-0.6-0.9
Conditioned reinforcement - inactives2.03.04.4-0.5-1.9-1.7-1.8-1.8-1.7-1.8-1.8-2.1
Conditioned locomotion0.00.00.10.4-0.10.00.1-0.10.00.0-0.1-0.2
Patch foraging indifference point 0 sec0.30.61.20.8-0.6-1.1-1.0-0.3-1.0-0.8-0.6-0.5
Patch foraging indifference point AUC2.43.54.0-1.3-2.0-2.0-2.0-2.0-1.9-2.0-1.8-1.9
Delay disc. indifference point, 0s delay1.61.72.10.81.41.31.31.51.31.41.41.2
Delay disc. indifference point, 16s delay0.10.10.6-0.80.10.30.20.30.20.20.20.4
Delay disc. indifference point, 2s delay1.82.03.0-0.11.41.61.41.71.61.41.31.7
Delay disc. indifference point, 24s delay0.20.31.1-1.0-0.4-0.4-0.5-0.3-0.4-0.5-0.4-0.1
Delay disc. indifference point, 4s delay2.02.13.20.21.51.71.61.41.81.61.51.3
Delay disc. indifference point, 8s delay1.01.11.50.11.01.21.11.11.21.11.11.1
Indifference point function ln k0.71.22.21.51.21.01.11.01.01.11.10.9
Indifference point function log k0.71.22.21.51.21.01.11.01.01.11.10.9
Patch foraging total patch changes 0 sec0.30.61.10.8-0.6-1.1-0.9-0.3-1.0-0.9-0.6-0.5
Patch foraging total patch changes 12 sec1.82.33.3-0.3-1.6-1.7-1.8-1.2-1.7-1.7-1.7-1.3
Patch foraging total patch changes 18 sec0.20.30.50.6-0.4-0.7-0.7-0.2-0.6-0.6-0.4-0.4
Patch foraging total patch changes 24 sec1.83.24.0-0.7-1.9-1.9-2.0-1.7-1.9-1.9-1.9-1.8
Patch foraging total patch changes 6 sec1.11.72.90.6-1.2-1.7-1.7-0.8-1.7-1.5-1.2-0.9
Patch foraging time to switch 0 sec0.10.10.3-0.50.20.40.30.40.40.3-0.10.5
Patch foraging water rate 0 sec0.00.10.30.3-0.1-0.4-0.2-0.1-0.3-0.20.1-0.6
Patch foraging water rate 12 sec1.02.02.91.41.51.41.51.51.41.41.71.0
Patch foraging water rate 18 sec0.10.10.20.40.30.30.30.20.20.40.5-0.3
Patch foraging water rate 24 sec0.30.42.21.50.50.40.40.40.40.50.6-0.3
Patch foraging water rate 6 sec1.92.83.81.91.81.51.61.81.41.61.71.5
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.3-0.10.10.1-0.10.10.2-0.2-0.3
Distance traveled before self-admin1.31.72.40.71.41.41.51.11.41.51.51.0
Distance traveled after self-admin0.00.10.3-0.4-0.2-0.00.0-0.2-0.00.10.0-0.5
Extensor digitorum longus weight0.00.10.20.20.20.30.2-0.10.30.1-0.2-0.5
Bone: elastic displacement4.95.611.03.32.32.12.22.42.12.22.22.3
Bone: elastic work1.82.37.12.71.41.21.41.51.21.41.31.0
Bone: endosteal estimation22.449.069.6-8.3-7.1-6.7-6.8-7.0-6.7-6.8-6.7-6.7
Bone: endosteal perimeter18.138.564.6-8.0-6.2-6.0-5.9-6.1-6.0-5.9-5.8-5.6
Epididymis fat weight0.41.34.22.01.10.60.71.80.60.70.61.0
Delta time in closed arm before/after self-admin2.32.22.8-0.9-1.5-1.7-1.6-1.4-1.7-1.6-1.6-1.1
Delta time in open arm before/after self-admin4.04.05.82.41.91.91.72.21.91.71.72.2
Diff in mean of infusions in LGA sessions2.02.43.01.31.51.71.61.51.71.51.71.4
Delay discount exponential model param1.01.11.40.3-1.0-1.2-1.0-1.1-1.2-1.1-1.0-1.1
Extinction: sum of active levers before priming0.90.91.40.1-1.0-1.1-1.2-0.8-1.1-1.2-1.1-0.7
Active lever presses in extinction session 60.30.30.4-0.20.50.60.50.70.60.50.70.6
Bone: final force1.21.93.9-0.5-1.5-1.3-1.4-1.5-1.2-1.3-1.4-2.0
Bone: final moment0.50.82.10.1-0.9-0.8-0.8-1.0-0.7-0.8-0.9-1.4
Food consumed during 24 hour testing period0.40.52.3-1.5-0.5-0.4-0.5-0.5-0.4-0.5-0.7-0.5
Glucose0.10.10.20.20.40.40.30.40.40.30.30.5
Heart weight0.10.20.90.3-0.4-0.4-0.60.0-0.3-0.6-0.9-0.3
Delay discount hyperbolic model param1.31.51.90.2-1.2-1.4-1.2-1.3-1.4-1.3-1.2-1.3
Intermittent access intake day 1-15 change1.53.23.81.81.81.91.81.71.91.81.61.6
Intermittent access intake escalation1.02.12.61.61.41.61.51.41.61.41.31.2
Intermittent access intake escalation 24.24.75.21.82.32.32.22.22.32.22.22.1
Intermitt. access day 1 inactive lever presses0.20.81.31.1-0.8-0.9-1.0-0.5-0.9-1.0-0.9-1.0
Intermitt. access day 15 inactive lever presses0.00.00.10.1-0.2-0.1-0.20.0-0.1-0.2-0.3-0.2
Intermitt. access escalation Index0.10.10.4-0.6-0.2-0.2-0.1-0.4-0.2-0.1-0.1-0.5
Intermittent access day 1 total infusions3.75.97.0-1.1-2.6-2.6-2.5-2.5-2.6-2.6-2.5-2.5
Intermittent access day 15 total infusions0.60.91.40.2-1.0-0.9-0.9-1.0-0.9-1.0-1.0-1.2
Intermittent access terminal intake (last 3 days)0.91.11.7-0.2-1.2-1.1-1.1-1.2-1.1-1.1-1.0-1.3
Intermittent access total infusions4.65.56.5-0.9-2.5-2.5-2.4-2.4-2.5-2.4-2.4-2.5
Intermittent access day 1 locomotion2.43.14.1-0.8-1.9-1.8-1.7-1.8-1.8-1.7-2.0-1.8
Intermittent access day 15 total locomotion0.10.21.11.0-0.4-0.4-0.3-0.1-0.4-0.4-0.4-0.4
Intermittent access total locomotion2.63.14.3-0.4-1.9-1.8-1.8-1.7-1.8-1.8-2.1-1.8
Intermittent access standard deviation0.10.20.60.1-0.3-0.2-0.3-0.6-0.2-0.3-0.2-0.8
Left kidney weight0.10.30.6-0.10.60.80.70.50.80.60.50.0
Right kidney weight0.52.23.10.81.61.81.71.41.71.71.60.8
Cocaine induced anxiety0.00.00.10.10.10.10.10.20.10.1-0.10.3
Post-drug Anxiety0.10.10.30.1-0.3-0.4-0.4-0.1-0.4-0.4-0.50.0
Baseline Anxiety0.50.50.8-0.3-0.7-0.9-0.9-0.5-0.9-0.9-0.8-0.5
Tail length0.41.64.61.11.20.80.72.00.90.70.62.1
Length with tail0.72.96.30.91.91.51.42.51.51.41.22.5
Length without tail1.13.74.81.12.22.02.02.11.92.01.82.0
Times rat made contact with spout1.41.73.50.31.31.21.21.51.21.21.11.9
Lifetime Intake5.16.27.5-1.1-2.7-2.6-2.5-2.7-2.6-2.6-2.5-2.7
Liver weight, left0.10.20.6-0.80.3-0.10.10.7-0.1-0.0-0.00.5
Liver weight, right0.30.51.31.10.70.60.60.70.60.70.60.4
Locomotor activity1.52.33.1-1.1-1.4-1.8-1.6-1.6-1.6-1.6-1.3-1.7
Locomotor testing distance0.61.21.80.0-0.9-1.3-1.2-0.9-1.2-1.1-1.0-1.3
Locomotor testing rearing0.10.10.30.4-0.3-0.5-0.5-0.1-0.4-0.4-0.1-0.4
Locomotion in novel chamber0.20.31.8-1.3-0.2-0.3-0.3-0.3-0.5-0.2-0.2-0.6
Locomotion in novel chamber post-restriction0.40.60.9-0.9-0.8-0.9-0.9-0.4-0.9-0.9-0.7-0.5
Fecal boli incidents, locomotor time 10.40.61.1-0.7-0.7-1.0-1.0-0.7-0.9-0.7-0.9-0.2
Change in fecal boli incidents, locomotor task0.70.71.20.90.80.90.90.80.90.71.10.4
Time >=10cm from walls, locomotor time 11.01.01.7-1.1-1.0-0.9-0.9-1.3-0.9-0.8-0.7-1.3
Bouts of movement, locomotor time 10.20.30.60.4-0.3-0.7-0.8-0.1-0.7-0.5-0.20.0
Total resting periods, locomotor time 10.10.10.30.4-0.1-0.5-0.50.1-0.4-0.3-0.00.3
Rest time, locomotor task time 10.60.81.20.70.90.80.70.80.90.91.11.1
Distance moved, locomotor task time 10.20.30.50.50.50.70.70.60.60.50.40.2
Vertical activity count, locomotor time 10.81.82.6-0.4-1.5-1.4-1.3-1.1-1.5-1.6-1.6-1.4
Time >=10cm from walls, locomotor time 20.10.10.50.70.1-0.1-0.00.3-0.1-0.10.10.2
Bouts of movement, locomotor time 20.61.01.51.21.01.00.91.10.90.90.91.0
Total resting periods, locomotor time 20.30.61.11.10.70.70.60.80.60.70.70.7
Rest time, locomotor task time 20.00.00.20.40.10.10.0-0.00.10.20.30.1
Distance moved, locomotor task time 20.00.10.1-0.20.20.30.30.40.20.20.10.0
Vertical activity count, locomotor time 20.00.00.10.3-0.1-0.2-0.00.1-0.2-0.2-0.3-0.1
Light reinforcement 10.20.51.60.1-0.7-0.6-0.6-0.8-0.6-0.6-0.7-1.3
Light reinforcement 22.53.84.3-1.5-2.0-2.0-2.0-1.9-2.1-2.0-2.0-2.0
Bone: marrow area22.048.167.5-8.2-7.0-6.7-6.7-6.9-6.7-6.8-6.6-6.6
Bone: maximum diameter11.521.525.9-5.1-4.7-4.5-4.5-4.9-4.5-4.5-4.5-4.5
Bone: maximum force2.74.87.1-1.5-2.3-2.2-2.2-2.2-2.1-2.2-2.3-2.7
Bone: maximum moment1.42.54.2-0.8-1.7-1.6-1.6-1.5-1.5-1.6-1.7-2.1
Mean time between licks in bursts0.41.01.6-1.3-0.9-1.0-1.0-0.9-1.0-1.0-0.9-1.0
Mean num. licks in bursts2.33.66.22.51.81.91.82.21.91.71.51.6
Cd content in liver0.30.31.51.20.50.40.20.60.30.30.40.6
Co content in liver2.12.53.41.11.71.71.81.31.61.81.61.4
Cu content in liver0.10.20.4-0.60.30.40.50.10.40.50.30.4
Fe content in liver0.10.10.50.2-0.2-0.5-0.3-0.1-0.4-0.3-0.7-0.1
K content in liver0.10.10.30.10.30.30.40.20.30.40.20.5
Mg content in liver0.00.00.1-0.20.10.10.1-0.00.10.2-0.00.2
Mn content in liver0.50.62.1-1.4-0.7-0.6-0.4-0.9-0.7-0.4-0.6-0.5
Na content in liver0.10.10.8-0.90.00.00.1-0.3-0.00.2-0.1-0.2
Rb content in liver0.20.31.1-0.1-0.5-0.4-0.4-0.8-0.3-0.3-0.4-1.0
Se content in liver0.00.00.1-0.10.10.20.2-0.10.20.20.10.2
Sr content in liver2.11.82.7-1.2-1.3-1.6-1.4-1.2-1.6-1.4-1.4-1.1
Zn content in liver1.11.21.80.51.21.21.30.81.21.31.20.7
Bone: minimum diameter7.413.519.4-4.4-3.8-3.6-3.6-3.7-3.5-3.6-3.4-3.4
Time in familiar zone, hab. session 10.10.10.30.50.20.10.10.40.10.10.00.3
Time in novel zone, hab. session 10.10.10.2-0.00.20.30.3-0.00.30.40.5-0.2
Total zone transitions, hab. session 10.20.20.90.30.60.40.30.90.30.30.20.5
Total locomotion distance, hab. session 10.10.10.20.1-0.2-0.3-0.30.1-0.4-0.3-0.2-0.5
Locomotion velocity, hab. session 10.20.30.5-0.1-0.4-0.7-0.6-0.1-0.7-0.6-0.5-0.4
Time in familiar zone, hab. session 21.01.11.30.81.11.11.11.21.11.11.00.8
Time in novel zone, hab. session 21.61.62.6-0.6-1.4-1.2-1.3-1.6-1.2-1.3-1.2-1.3
Total zone transitions, hab. session 20.30.40.7-0.2-0.5-0.7-0.7-0.3-0.8-0.8-0.8-0.5
Total locomotion distance, hab. session 20.20.20.40.1-0.4-0.5-0.5-0.3-0.7-0.5-0.5-0.6
Locomotion velocity, hab. session 20.20.30.5-0.2-0.5-0.5-0.5-0.4-0.7-0.5-0.5-0.7
Novel to familiar place preference ratio0.10.10.20.10.30.30.40.30.30.40.30.1
Novelty place preference0.00.00.1-0.10.10.10.20.10.10.20.1-0.1
Time in novel zone, NPP test0.00.00.00.10.0-0.00.10.0-0.00.10.0-0.2
Total zone transitions, NPP test0.20.30.60.4-0.3-0.7-0.70.2-0.8-0.7-0.70.2
Total locomotion distance, NPP test0.40.61.41.2-0.4-0.9-0.80.2-1.0-0.8-0.60.0
Locomotion velocity, NPP test0.20.31.51.2-0.0-0.4-0.40.5-0.5-0.4-0.20.4
Intraocular pressure1.72.43.5-1.2-1.5-1.7-1.7-1.3-1.8-1.6-1.9-1.2
Delta distance traveled before/after self-admin2.12.23.7-1.2-1.6-1.4-1.5-1.5-1.4-1.4-1.5-1.9
Delta ambulatory time before/after self-admin1.92.43.9-1.8-1.6-1.4-1.4-1.5-1.4-1.3-1.4-2.0
Parametrial fat weight0.20.50.7-0.4-0.8-0.7-0.7-0.7-0.7-0.8-0.8-0.7
Pavlov. Cond. lever latency1.41.82.4-1.3-1.4-1.2-1.4-1.5-1.2-1.3-1.2-1.4
Pavlov. Cond. magazine entry latency4.35.67.41.62.42.62.72.22.62.62.61.8
Pavlov. Cond. change in total contacts1.31.42.21.51.21.11.31.41.01.21.10.9
Pavlov. Cond. index score2.32.93.71.41.71.81.91.71.81.81.81.4
Pavlov. Cond. latency score2.73.54.31.41.91.92.11.91.92.01.91.7
Pavlov. Cond. lever contacts1.51.82.41.41.41.21.41.51.21.31.21.3
Pavlov. Cond. magazine entry number4.35.57.1-1.7-2.3-2.5-2.7-2.2-2.5-2.5-2.5-1.8
Pavlov. Cond. intertrial magazine entries0.40.51.20.2-0.7-0.7-0.9-0.3-0.8-0.9-1.1-0.4
Pavlov. Cond. lever-magazine prob. diff.2.02.43.21.21.61.61.81.51.61.71.71.2
Pavlov. Cond. response bias2.53.13.81.61.71.82.01.81.81.81.81.3
Pavlov. Cond. lever latency1.62.12.70.81.51.61.51.51.51.51.51.4
Pavlov. Cond. magazine entry latency3.84.55.4-1.4-2.2-2.3-2.3-2.2-2.2-2.3-2.3-1.8
Pavlov. Cond. change in total contacts3.45.46.3-1.3-2.4-2.5-2.5-2.4-2.4-2.4-2.4-2.3
Pavlov. Cond. index score3.44.65.7-1.4-2.2-2.4-2.3-2.1-2.3-2.3-2.3-1.9
Pavlov. Cond. latency score3.85.16.1-1.5-2.3-2.5-2.4-2.2-2.4-2.4-2.4-2.0
Pavlov. Cond. lever contacts1.42.02.6-0.8-1.5-1.6-1.5-1.3-1.5-1.4-1.5-1.3
Pavlov. Cond. magazine entry number4.04.95.91.32.22.42.42.32.32.32.32.1
Pavlov. Cond. intertrial magazine entries0.10.21.2-1.1-0.4-0.2-0.1-0.3-0.2-0.1-0.2-0.5
Pavlov. Cond. lever-magazine prob. diff.3.34.45.4-1.4-2.1-2.3-2.3-2.1-2.2-2.2-2.2-1.9
Pavlov. Cond. response bias1.92.63.4-0.8-1.7-1.8-1.7-1.6-1.7-1.7-1.6-1.5
Time in closed arm before self-admin0.81.01.7-1.1-1.0-0.9-1.0-1.1-0.9-1.0-0.7-1.3
Time in closed arm after self-admin2.32.44.2-1.8-1.6-1.3-1.4-1.8-1.3-1.4-1.2-2.0
Time in open arm before self-admin0.60.61.10.60.90.60.80.90.60.80.71.1
Time in open arm after self-admin0.50.61.81.30.60.30.31.00.30.30.11.3
Bone: periosteal estimation11.925.129.0-5.4-5.2-4.9-4.9-5.1-4.9-4.9-4.8-5.0
Bone: periosteal perimeter6.310.917.0-4.1-3.3-3.3-3.0-3.4-3.3-3.0-3.0-3.1
Bone: post-yield work5.68.29.4-3.1-2.9-2.8-2.8-2.7-2.7-2.9-2.8-2.9
Progressive ratio test 1 active lever presses0.30.30.60.4-0.6-0.6-0.5-0.4-0.6-0.5-0.8-0.7
Progressive ratio test 1 breakpoint0.40.50.90.3-0.7-0.8-0.7-0.5-0.8-0.7-0.9-0.7
Progressive ratio test 1 inactive lever presses1.42.13.8-0.2-1.5-1.4-1.4-1.5-1.4-1.4-1.6-1.9
Progressive ratio test 2 active lever presses0.91.01.4-0.3-1.1-1.0-1.0-1.1-1.0-1.0-1.2-1.2
Progressive ratio test 2 breakpoint1.01.21.5-0.4-1.2-1.1-1.1-1.2-1.1-1.1-1.2-1.2
Progressive ratio test 2 inactive lever presses0.71.21.50.1-1.2-1.1-1.1-1.1-1.1-1.2-1.2-1.2
Incentive Sensitization - Responses0.10.20.4-0.5-0.4-0.3-0.3-0.6-0.3-0.3-0.4-0.6
Incentive Sensitization - Breakpoint0.10.20.4-0.6-0.4-0.2-0.2-0.6-0.2-0.2-0.3-0.6
Sum of active levers in priming session hrs 5-61.11.12.01.41.00.91.01.10.90.91.20.7
Progressive ratio1.72.74.1-2.0-1.6-1.7-1.7-1.8-1.7-1.6-1.5-1.2
Food seeking constrained by brief footshock0.30.41.0-0.40.60.60.60.30.60.71.00.4
Seeking ratio, punishment vs. effort1.21.72.01.21.31.41.41.21.41.41.30.9
Retroperitoneal fat weight0.10.63.61.90.4-0.10.21.1-0.10.10.10.4
Reaction time number correct0.00.00.10.3-0.0-0.2-0.10.2-0.2-0.1-0.10.0
Reaction time mean minus median0.00.00.2-0.30.00.10.00.3-0.00.10.40.2
Reaction time mean minus median AUC0.10.30.8-0.9-0.5-0.4-0.5-0.6-0.4-0.4-0.0-0.7
Reaction time num false alarms0.10.20.7-0.9-0.3-0.3-0.3-0.5-0.2-0.3-0.1-0.4
Reaction time num false alarms AUC0.10.10.9-1.0-0.2-0.2-0.2-0.4-0.2-0.2-0.1-0.2
Reaction time trials correct on left0.00.00.10.3-0.0-0.2-0.10.2-0.2-0.1-0.10.0
Reaction time trials on left0.00.00.10.2-0.1-0.2-0.20.1-0.2-0.2-0.1-0.0
Reaction time mean0.20.40.6-0.6-0.7-0.6-0.7-0.5-0.6-0.7-0.4-0.5
Reaction time mean AUC0.50.91.2-0.6-1.1-1.0-1.1-0.9-1.0-1.1-0.7-0.8
Median of all reaction times0.70.91.2-0.7-1.1-1.0-1.1-1.0-0.9-1.1-0.9-0.8
Reaction time omissions0.30.51.5-1.2-0.7-0.5-0.5-0.5-0.6-0.6-0.4-0.6
Reaction time false alarm rate0.10.10.8-0.90.00.10.1-0.20.20.10.20.0
Reaction time premature initiation rate4.66.37.62.02.62.62.62.82.62.62.62.1
Reaction time premature initiations1.93.44.61.61.91.81.92.11.81.81.91.5
Std. dev. reaction times0.00.00.1-0.3-0.1-0.0-0.10.2-0.1-0.10.30.2
Reaction time trials completed0.00.00.10.2-0.1-0.2-0.20.1-0.2-0.2-0.1-0.0
Reaction time trials AUC0.00.10.10.2-0.2-0.3-0.30.0-0.3-0.3-0.2-0.1
Run reversals in cocaine runway, females0.50.50.70.80.80.70.60.70.60.80.70.7
Run reversals in cocaine runway, males0.00.00.20.50.10.10.1-0.00.10.10.1-0.1
Latency to leave start box in cocaine runway0.91.01.71.30.91.01.10.71.21.11.00.4
Latency to leave start box in cocaine runway, F2.02.33.81.91.51.41.61.51.71.51.41.0
Latency to leave start box in cocaine runway, M0.60.61.4-0.8-0.8-0.5-0.5-1.2-0.5-0.4-0.5-1.1
Std. dev. time between licks in bursts1.82.53.4-0.4-1.5-1.8-1.8-1.4-1.8-1.7-1.7-1.6
Total sessions with >9 infusions0.10.20.50.1-0.4-0.2-0.2-0.6-0.2-0.2-0.4-0.7
Short access day 1 total inactive lever presses3.04.05.4-0.9-2.1-2.0-2.0-2.1-2.0-2.0-2.1-2.3
Short access day 10 total inactive lever presses0.51.21.5-0.4-1.1-1.2-1.2-0.9-1.2-1.2-1.2-1.2
Short access day 1 total infusions1.21.63.1-0.6-1.4-1.2-1.1-1.7-1.2-1.1-1.1-1.8
Short access day 10 total infusions2.63.45.9-1.2-2.0-1.8-1.7-2.2-1.8-1.7-1.6-2.4
Short access total infusions3.84.96.9-1.3-2.4-2.2-2.1-2.5-2.2-2.2-2.1-2.6
Short access day 1 locomotion0.20.20.70.1-0.5-0.4-0.3-0.6-0.4-0.3-0.5-0.8
Short access day 10 total locomotion0.71.31.6-1.3-1.2-1.0-1.0-1.3-1.0-0.9-1.2-1.2
Short access total locomotion0.20.20.7-0.2-0.5-0.3-0.2-0.7-0.3-0.2-0.6-0.9
One hour access (0.3 mA shock)0.80.91.4-0.4-1.0-0.9-0.9-1.1-0.9-0.9-1.1-1.2
Compulsive drug intake1.92.22.7-1.0-1.5-1.6-1.6-1.4-1.6-1.6-1.6-1.5
One hour access (shock baseline)0.10.10.3-0.3-0.4-0.3-0.3-0.5-0.3-0.3-0.4-0.4
Social response proportion0.30.30.8-0.00.60.60.70.50.60.70.90.1
Social responses0.81.01.40.81.11.01.20.91.01.21.10.3
Social time0.10.10.5-0.5-0.3-0.2-0.1-0.3-0.2-0.1-0.1-0.7
Soleus weight0.82.24.0-2.0-1.4-1.1-1.1-2.0-1.1-1.2-1.3-1.8
Bone: stiffness4.67.610.3-2.5-2.8-2.6-2.7-2.8-2.6-2.8-2.6-3.2
Tibialis anterior weight0.00.10.3-0.50.10.40.3-0.40.40.30.2-0.6
Time to tail flick, vehicle, before self-admin1.11.11.8-0.7-1.0-1.1-1.2-0.8-1.1-1.3-1.4-0.8
Time to tail flick, vehicle, after self-admin0.60.91.5-0.40.91.11.00.61.11.01.20.6
Time to tail flick, test, before self-admin0.30.30.7-0.20.50.30.40.80.30.50.50.9
Time to tail flick, test, after self-admin1.92.02.90.71.51.31.41.61.31.51.31.7
Delta time to tail flick, vehicle, before/after SA3.13.04.50.91.71.81.91.61.81.92.11.4
Delta time to tail flick, test, before/after SA0.30.30.40.70.60.60.60.40.60.60.40.6
Tibia length0.41.11.80.61.01.31.20.61.21.21.30.7
Ambulatory time before self-admin2.43.64.21.52.02.02.01.82.02.02.11.7
Ambulatory time after self-admin0.00.00.1-0.10.20.20.20.20.20.30.2-0.0
Bone: tissue strength0.50.53.11.80.40.50.50.40.40.40.4-0.1
Total heroin consumption0.10.10.1-0.20.20.40.30.00.40.20.20.3
Bone: trabecular number0.10.10.3-0.50.30.30.40.30.30.40.30.2
Bone: trabecular spacing0.10.10.40.6-0.2-0.1-0.2-0.2-0.1-0.2-0.1-0.1
Bone: trabecular thickness0.00.10.4-0.6-0.1-0.2-0.10.0-0.3-0.1-0.2-0.0
Bone: trabecular tissue density0.00.10.3-0.00.10.10.10.50.20.10.10.5
Water consumed over 24 hours0.00.10.2-0.40.10.10.00.40.10.00.00.5
Number of responses in last shaping day2.52.83.8-1.4-1.7-1.6-1.6-1.7-1.6-1.6-1.8-2.0