LOC134480640

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr10_98396502_98401576	0.06	0.04	2.7e-03	0.05	0.04	0.03	0.01	7.3e-05	6.4e-04	1.9e-03	5.4e-02
2	NAcc	intron excision ratio	chr10_98396502_98401576	0.08	0.04	2.2e-08	0.04	0.06	0.05	0.05	2.6e-07	5.0e-09	3.0e-08	1.4e-08
3	NAcc	intron excision ratio	chr10_98396502_98402529	0.1	0.04	1.3e-10	0.09	0.08	0.07	0.08	6.6e-13	1.2e-11	1.5e-10	7.8e-12
4	pVTA	intron excision ratio	chr10_98396502_98402529	0.05	0.03	6.9e-03	0.04	0.04	0.02	0.01	7.0e-04	5.8e-04	7.0e-03	4.3e-02
5	NAcc	intron excision ratio	chr10_98401674_98402529	0.04	0.02	2.1e-05	0.05	0.03	0.04	0.02	6.8e-08	7.6e-06	1.1e-06	1.3e-03
6	pVTA	gene expression	LOC134480640	0.37	0.14	1.1e-06	0.1	0.1	0.1	0.1	1.7e-08	1.8e-08	2.4e-08	1.5e-08
7	PL	gene expression	LOC134480640	0.23	0.1	2.6e-05	0.05	0.04	0.07	0.05	2.8e-06	2.4e-05	1.3e-08	1.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.2	0.3	0.9	-0.0	1.0	-0.4	-0.0	0.0	-0.0	0.9
Area under the delay curve	2.2	2.6	6.1	-0.9	-2.5	2.3	0.8	-1.6	1.0	1.3
BMI with tail	1.0	3.3	7.2	0.5	2.7	-1.8	-0.4	2.5	-1.7	-1.7
BMI without tail	0.1	0.3	0.8	0.1	-0.3	-0.1	-0.8	0.9	-0.1	-0.8
Body weight	0.1	0.3	0.7	0.1	-0.4	0.2	-0.5	0.6	0.6	0.9
Weight adjusted by age	0.3	0.4	1.5	-0.5	-0.4	0.3	-0.4	1.2	-0.3	-0.7
Bone surface	1.8	3.4	12.0	2.5	0.8	-0.8	-1.9	0.2	-0.6	3.5
Bone volume	0.9	1.7	6.5	1.8	0.3	-0.3	-1.3	-0.3	-0.3	2.6
Breakpoint value in progressive ratio session	2.2	2.7	5.1	-1.6	-1.7	1.9	1.7	-2.3	1.3	0.1
Number of licking bursts	0.4	0.7	2.2	1.0	-1.5	0.5	-0.4	-1.1	-0.2	0.4
Context. condit. distance diff. score	0.3	0.4	0.7	-0.7	0.9	-0.4	0.4	0.8	-0.1	-0.8
Locomotion velocity, session 1	0.8	0.8	2.1	0.2	-1.5	0.6	-0.3	-1.4	0.9	0.7
Locomotion distance, session 1	0.2	0.3	0.7	0.1	-0.8	-0.2	-0.8	-0.1	0.5	-0.7
Locomotion velocity, session 2	0.6	0.6	1.3	1.0	0.4	-1.1	-1.2	-0.5	-0.4	-0.7
Locomotion distance, session 2	0.9	1.2	3.7	1.5	0.0	-1.3	-1.9	0.5	-0.1	-0.7
Locomotion velocity, session 3	0.2	0.2	0.8	-0.6	-0.5	0.4	0.1	-0.2	0.9	-0.3
Locomotion distance, session 3	1.8	1.9	2.9	1.5	1.4	-1.7	-1.3	1.2	-1.0	-1.5
Stereotopy head waving bouts, day 3	0.8	0.9	2.7	-1.6	0.2	0.7	1.7	-0.6	0.6	-0.0
Stereotopy head waving duration, day 3	0.1	0.2	0.6	-0.4	0.5	-0.1	0.8	-0.3	-0.2	-0.3
Locomotion velocity, session 7	2.0	2.2	4.3	1.8	1.5	-2.1	-1.8	0.7	-0.8	-1.0
Locomotion distance, session 7	5.2	6.6	9.8	2.9	1.8	-3.1	-3.1	2.4	-1.8	-2.5
Stereotopy head waving bouts, day 7	1.5	1.7	3.5	-1.8	0.6	0.9	1.9	-0.4	0.9	1.7
Stereotopy head waving duration, day 7	1.1	1.3	4.0	-1.6	0.9	0.7	2.0	-0.6	0.1	1.2
Locomotion velocity, session 8	0.5	0.6	2.0	1.4	0.1	-0.8	-1.0	-0.1	-0.4	-0.4
Locomotion distance, session 8	1.6	2.3	3.9	1.3	1.2	-2.0	-1.9	1.6	-0.8	-1.4
Degree of sensitization distance	0.7	0.7	2.0	0.8	0.1	-0.9	-1.4	1.0	-0.6	-0.6
Degree of sensitization stereotypy	1.1	1.2	2.5	-1.5	0.6	0.7	1.6	-0.2	0.6	1.5
Conditioned locomotion	0.2	0.2	0.8	0.1	0.5	-0.1	-0.1	0.9	-0.6	-0.3
Cocaine response after cond. corrected	0.7	0.9	2.9	-1.3	-0.3	1.1	1.7	-0.2	0.2	0.4
Cocaine response after cond. not corrected	0.4	0.4	0.8	-0.7	-0.6	0.8	0.9	-0.3	0.6	0.6
Cocaine response before conditioning	1.1	1.3	4.0	1.6	0.3	-1.4	-2.0	0.7	0.3	0.2
Saline control response	0.5	0.6	2.8	-0.0	-0.4	0.2	-0.8	0.5	0.7	1.7
Bone: connectivity density	0.7	1.0	2.6	0.7	1.6	-1.0	-0.7	0.9	-1.1	0.7
Bone: cortical apparent density	2.0	2.7	5.9	-2.4	-1.6	1.9	1.9	-0.8	1.2	-1.1
Bone: cortical area	3.2	4.9	13.9	1.0	3.7	-2.9	-1.2	2.7	-0.7	1.2
Bone: cortical porosity	0.8	0.9	4.1	0.9	0.5	-0.4	-0.6	-0.5	0.5	2.0
Bone: cortical porosity	0.8	0.9	3.8	1.0	0.2	-0.2	-0.6	-0.8	0.4	1.9
Bone: cortical thickness	3.1	5.1	11.3	-3.4	2.8	-0.8	2.4	1.8	2.4	0.9
Bone: cortical thickness	1.1	1.3	3.4	-1.4	1.8	-0.7	1.0	0.7	0.9	1.1
Bone: cortical tissue density	2.3	3.1	6.1	-2.5	-1.9	2.1	2.0	-1.0	1.2	-1.1
Condit. Reinf. active minus inactive responses	2.1	2.3	6.5	0.2	1.3	-1.3	-0.8	1.7	-1.7	-2.6
Condit. Reinf. active-inactive response ratio	3.3	3.5	7.7	0.2	1.9	-1.7	-0.8	2.2	-2.2	-2.8
Condit. Reinf. active responses	0.9	1.1	4.2	-0.2	0.7	-0.7	-0.4	1.2	-0.9	-2.1
Condit. Reinf. inactive responses	0.5	0.6	1.5	-0.2	-0.9	0.7	0.1	-0.7	1.2	0.8
Incentive salience index mean	0.9	1.0	3.9	-0.2	0.6	-0.6	-0.4	1.1	-1.1	-2.0
Condit. Reinf. lever presses	0.1	0.1	0.5	-0.4	-0.1	0.0	-0.2	0.7	-0.1	-0.6
Condit. Reinf. active minus inactive responses	0.7	0.9	2.3	0.9	1.5	-1.3	-0.6	0.1	0.0	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	1.0	0.2	-0.7	-0.9	-0.4	-0.1	0.0
Condit. Reinf. active responses	0.9	1.3	2.9	1.1	1.7	-1.6	-1.0	0.7	-0.1	0.9
Condit. Reinf. inactive responses	0.9	1.2	3.2	0.3	1.8	-1.3	-0.6	1.2	0.1	1.1
Condit. Reinf. lever presses	2.1	2.9	5.2	2.1	1.6	-2.2	-2.3	1.3	-1.0	-0.1
Condit. Reinf. lever reinforcers received	1.3	1.8	3.8	1.4	1.8	-2.0	-1.5	1.0	-0.4	0.6
Conditioned reinforcement - actives	0.7	1.3	3.1	0.6	1.8	-1.4	-0.4	1.2	-1.1	-0.7
Conditioned reinforcement - inactives	3.4	5.0	7.9	1.8	2.6	-2.5	-2.0	2.8	-2.2	-1.4
Conditioned locomotion	0.2	0.3	1.0	0.1	1.0	-0.7	-0.1	0.8	-0.4	-0.1
Patch foraging indifference point 0 sec	0.9	1.7	3.3	0.6	1.8	-1.8	-1.2	1.8	-0.7	-0.3
Patch foraging indifference point AUC	1.7	2.5	4.2	1.8	0.2	-1.0	-1.9	1.4	-1.8	-2.0
Delay disc. indifference point, 0s delay	1.0	1.1	2.1	-1.4	-0.5	1.1	1.3	-0.4	0.8	1.4
Delay disc. indifference point, 16s delay	0.8	0.8	2.1	-0.2	-1.4	1.2	0.1	-0.8	0.4	1.2
Delay disc. indifference point, 2s delay	5.4	6.1	13.3	-1.3	-3.6	3.1	1.1	-2.5	2.0	2.4
Delay disc. indifference point, 24s delay	0.6	0.7	1.7	0.4	-1.3	0.9	-0.5	-0.9	0.5	0.9
Delay disc. indifference point, 4s delay	2.9	3.0	6.5	-1.5	-1.9	2.6	1.8	-1.8	1.1	1.0
Delay disc. indifference point, 8s delay	1.7	2.0	5.0	-1.1	-2.2	2.1	1.0	-1.4	0.8	0.4
Indifference point function ln k	0.6	1.1	2.3	-1.1	1.5	-0.5	0.8	1.1	0.9	1.1
Indifference point function log k	0.6	1.1	2.3	-1.1	1.5	-0.5	0.8	1.1	0.9	1.1
Patch foraging total patch changes 0 sec	0.9	1.7	3.5	0.6	1.8	-1.8	-1.2	1.9	-0.6	-0.2
Patch foraging total patch changes 12 sec	1.8	2.3	4.2	1.7	1.3	-1.8	-2.1	1.3	-1.2	-0.7
Patch foraging total patch changes 18 sec	0.3	0.5	0.9	0.4	0.9	-0.9	-0.8	0.9	-0.4	-0.5
Patch foraging total patch changes 24 sec	1.9	3.3	5.6	1.9	2.1	-2.4	-2.0	1.5	-1.6	-0.7
Patch foraging total patch changes 6 sec	1.7	2.6	4.8	1.2	0.8	-1.6	-2.2	2.2	-1.1	-1.7
Patch foraging time to switch 0 sec	0.5	1.0	3.6	0.1	-1.4	0.9	0.4	-1.9	0.7	0.5
Patch foraging water rate 0 sec	0.3	0.7	2.9	-0.1	0.9	-0.6	-0.7	1.7	-0.6	-0.2
Patch foraging water rate 12 sec	0.4	0.8	2.9	-1.7	0.4	0.4	1.2	0.1	0.6	0.6
Patch foraging water rate 18 sec	0.6	0.9	2.0	-0.5	1.4	-0.7	0.1	1.4	-0.9	-1.0
Patch foraging water rate 24 sec	1.8	2.6	6.8	-0.6	2.6	-1.7	-0.1	2.5	-0.6	-1.2
Patch foraging water rate 6 sec	0.8	1.2	3.0	-1.7	-0.1	0.6	1.1	-0.3	1.5	1.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.2	-0.1	0.1	-0.2	0.1	-0.3	0.4
Distance traveled before self-admin	1.0	1.3	3.2	-1.5	-0.4	1.2	1.8	-0.7	0.7	0.7
Distance traveled after self-admin	0.3	0.4	1.3	-0.0	-0.2	0.1	-0.2	0.2	-1.1	-1.2
Extensor digitorum longus weight	0.1	0.2	1.1	0.2	0.2	-0.4	-0.1	0.3	-0.6	-1.0
Bone: elastic displacement	1.6	1.8	4.7	-2.2	0.7	0.3	1.7	0.1	2.0	0.9
Bone: elastic work	1.2	1.5	5.5	-1.3	2.3	-1.1	0.5	1.2	0.7	0.5
Bone: endosteal estimation	8.5	18.7	44.3	6.7	2.2	-3.8	-5.8	2.7	-5.1	-0.0
Bone: endosteal perimeter	5.7	12.1	33.8	5.8	0.9	-2.4	-4.9	1.5	-4.2	0.9
Epididymis fat weight	0.2	0.7	2.1	-0.6	-1.5	0.5	-0.9	0.3	1.0	-0.3
Delta time in closed arm before/after self-admin	1.0	0.9	2.6	1.6	0.7	-1.4	-1.1	-0.2	-0.3	0.4
Delta time in open arm before/after self-admin	2.0	2.0	5.0	-1.7	-1.1	1.7	1.1	-0.2	2.2	0.8
Diff in mean of infusions in LGA sessions	1.2	1.4	2.9	-1.7	-1.0	1.5	1.6	-1.0	0.2	-0.4
Delay discount exponential model param	2.7	3.0	7.0	1.0	2.6	-2.5	-0.9	1.8	-1.1	-1.2
Extinction: sum of active levers before priming	0.7	0.7	1.5	1.1	1.1	-1.2	-1.0	0.1	-0.4	-0.0
Active lever presses in extinction session 6	1.2	1.2	2.2	-0.7	-1.4	1.5	0.5	-1.5	0.8	0.7
Bone: final force	4.2	6.7	17.8	1.4	4.2	-3.2	-1.6	3.3	-1.7	0.3
Bone: final moment	3.5	5.7	17.1	0.9	4.1	-2.9	-1.2	3.1	-1.2	0.7
Food consumed during 24 hour testing period	0.4	0.5	2.5	0.7	-0.3	0.0	-0.7	0.0	-0.1	1.6
Glucose	0.3	0.5	1.0	-0.3	-0.6	0.6	0.5	-1.0	0.9	0.9
Heart weight	0.7	1.0	2.4	0.9	1.2	-0.8	-1.1	1.6	-0.3	0.8
Delay discount hyperbolic model param	3.4	3.8	8.3	1.2	2.9	-2.7	-1.1	2.1	-1.4	-1.5
Intermittent access intake day 1-15 change	0.5	1.1	2.7	-1.6	-0.5	1.3	1.6	-0.1	0.7	0.1
Intermittent access intake escalation	0.3	0.6	1.8	-1.3	-0.0	0.8	1.3	-0.0	0.3	-0.1
Intermittent access intake escalation 2	2.3	2.6	4.9	-2.2	-1.5	2.0	2.0	-1.1	1.1	0.5
Intermitt. access day 1 inactive lever presses	0.9	3.6	8.8	0.9	2.5	-2.2	-1.6	3.0	-0.6	-1.1
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.3	-0.1	0.0	-0.5	0.3	0.1	0.2
Intermitt. access escalation Index	0.0	0.0	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.1	0.1
Intermittent access day 1 total infusions	3.9	6.2	9.0	2.5	2.4	-3.0	-2.7	3.0	-2.2	-1.4
Intermittent access day 15 total infusions	1.7	2.5	5.9	1.0	1.6	-1.6	-1.3	2.4	-1.7	-1.1
Intermittent access terminal intake (last 3 days)	1.9	2.5	5.0	1.0	1.6	-1.6	-1.3	2.2	-1.7	-1.2
Intermittent access total infusions	6.0	7.2	11.6	2.4	2.3	-2.9	-2.7	3.4	-2.7	-2.1
Intermittent access day 1 locomotion	2.7	3.5	6.0	2.0	1.7	-2.1	-2.1	2.5	-1.4	-0.7
Intermittent access day 15 total locomotion	1.0	1.8	5.1	0.4	1.6	-1.3	-1.0	2.3	-1.1	-1.0
Intermittent access total locomotion	4.0	4.8	8.7	2.1	2.1	-2.4	-2.3	2.9	-1.8	-1.3
Intermittent access standard deviation	0.6	1.2	3.1	0.2	1.2	-0.8	-0.2	1.8	-1.5	-1.1
Left kidney weight	0.2	0.7	3.5	-0.5	0.7	0.4	0.7	-0.2	-0.0	1.9
Right kidney weight	0.2	0.9	2.5	-1.6	0.3	1.1	1.3	0.2	-0.1	1.1
Cocaine induced anxiety	0.2	0.2	0.7	0.1	-0.8	0.4	-0.1	-0.2	0.8	0.4
Post-drug Anxiety	0.3	0.3	0.8	0.5	-0.5	-0.1	-0.6	-0.1	0.9	0.5
Baseline Anxiety	0.3	0.3	0.8	0.8	0.1	-0.6	-0.9	0.0	-0.3	-0.4
Tail length	1.3	5.0	12.7	-0.6	-3.6	2.1	-0.3	-2.1	2.9	2.2
Length with tail	1.6	6.9	12.0	-1.2	-3.5	2.6	0.7	-2.6	3.1	3.4
Length without tail	1.1	3.6	5.2	-1.8	-1.1	1.9	2.2	-2.0	1.9	2.3
Times rat made contact with spout	3.6	4.1	10.0	-1.1	-3.2	2.4	1.0	-2.4	1.6	1.4
Lifetime Intake	6.7	8.1	13.2	2.5	2.7	-3.1	-2.7	3.6	-2.9	-2.1
Liver weight, left	0.7	1.2	4.8	0.0	-0.9	0.5	-0.4	-0.9	1.2	2.2
Liver weight, right	0.3	0.5	1.2	-0.6	1.1	-0.4	0.2	0.9	0.3	1.1
Locomotor activity	1.1	1.7	2.6	1.3	0.7	-1.4	-1.6	1.2	-1.3	-1.6
Locomotor testing distance	1.1	2.0	3.6	1.0	1.1	-1.6	-1.7	1.9	-0.9	-1.5
Locomotor testing rearing	0.2	0.4	1.2	0.1	0.2	-0.5	-0.9	1.1	-0.3	-0.8
Locomotion in novel chamber	0.2	0.3	0.9	0.2	-0.8	0.3	-0.5	-0.9	-0.2	0.3
Locomotion in novel chamber post-restriction	0.3	0.4	1.1	0.7	0.5	-0.7	-1.0	0.1	-0.2	0.7
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.9	0.1	-0.6	-0.6	-0.3	-0.1	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.2	-1.1	0.0	0.4	0.5	0.8	-0.0	-0.7
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.9	0.7	1.4	-1.0	-0.4	0.6	-1.2	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.2	-0.5	-0.1	-0.8	0.5	0.6	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.8	0.0	-0.8	0.3	-0.4	-0.2	0.9	0.0
Rest time, locomotor task time 1	0.6	0.7	1.5	-1.1	-0.1	0.7	1.2	-0.9	0.9	0.5
Distance moved, locomotor task time 1	0.2	0.2	1.0	-0.4	-1.0	0.6	0.1	-0.0	0.3	0.3
Vertical activity count, locomotor time 1	1.1	2.6	5.2	1.6	0.6	-1.5	-2.3	2.1	-1.3	-1.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.1	-0.2	-0.1	-0.3	0.4	0.6	0.5
Bouts of movement, locomotor time 2	0.6	1.0	2.1	-0.9	-1.5	1.1	0.7	-1.0	1.1	-0.4
Total resting periods, locomotor time 2	0.5	0.8	2.2	-0.7	-1.5	1.0	0.4	-0.9	0.7	-0.7
Rest time, locomotor task time 2	0.1	0.1	0.5	-0.3	0.7	-0.1	0.5	-0.4	-0.0	-0.3
Distance moved, locomotor task time 2	0.2	0.3	0.9	-0.1	-0.7	0.2	-0.2	0.5	0.2	0.9
Vertical activity count, locomotor time 2	0.4	0.5	1.9	0.3	0.4	-0.7	-0.7	1.4	-0.4	-0.3
Light reinforcement 1	1.2	2.9	5.8	0.7	1.9	-1.6	-1.1	2.4	-2.0	-1.5
Light reinforcement 2	1.8	2.8	4.9	2.0	1.0	-1.8	-2.2	1.6	-1.7	-1.0
Bone: marrow area	8.5	18.5	43.5	6.6	2.3	-3.8	-5.8	2.7	-5.1	-0.0
Bone: maximum diameter	6.0	11.1	19.9	4.5	3.3	-3.7	-3.6	2.8	-3.5	0.6
Bone: maximum force	4.4	7.8	15.7	2.3	4.0	-3.4	-2.5	3.3	-2.1	0.4
Bone: maximum moment	3.5	6.1	14.5	1.7	3.8	-3.1	-2.0	3.1	-1.6	0.7
Mean time between licks in bursts	0.2	0.4	1.2	0.9	0.2	-0.8	-1.1	-0.3	-0.5	-0.2
Mean num. licks in bursts	0.4	0.6	2.3	-1.5	-0.1	0.6	0.8	0.0	0.9	0.1
Cd content in liver	0.2	0.2	0.7	-0.4	-0.0	-0.3	-0.2	0.8	0.7	-0.3
Co content in liver	1.3	1.5	3.8	-1.6	-0.9	1.4	2.0	-1.0	0.5	-0.5
Cu content in liver	0.4	0.5	1.5	-0.3	-0.2	0.8	0.9	-0.6	0.0	1.2
Fe content in liver	0.5	0.7	1.5	0.7	1.2	-1.1	-0.4	0.7	0.2	0.8
K content in liver	1.2	1.1	3.4	-0.2	-1.5	1.1	0.8	-1.8	0.8	-0.2
Mg content in liver	0.5	0.5	1.6	0.0	-1.3	1.0	0.3	-0.8	0.0	-0.7
Mn content in liver	0.3	0.3	1.2	0.6	0.5	0.0	-0.0	0.1	-0.4	1.1
Na content in liver	0.9	1.0	2.9	0.1	-1.2	1.0	0.6	-1.7	-0.1	-1.0
Rb content in liver	1.3	1.5	4.2	0.4	0.8	-0.6	-0.5	1.7	-1.4	-2.0
Se content in liver	1.0	1.1	3.7	-0.1	-1.9	1.4	0.1	-0.4	0.0	-1.4
Sr content in liver	1.1	0.9	1.9	1.4	-0.2	-0.6	-1.4	0.4	-1.3	-0.8
Zn content in liver	0.9	1.0	2.1	-1.2	-0.6	1.3	1.5	-1.0	0.1	-0.4
Bone: minimum diameter	3.2	5.9	11.4	3.4	2.2	-2.4	-2.9	1.6	-2.6	1.3
Time in familiar zone, hab. session 1	0.4	0.3	1.0	-0.0	0.8	-0.5	-0.2	1.0	0.2	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.9	-0.5	-0.3	0.5	0.3	0.3	-0.6	-0.9
Total zone transitions, hab. session 1	0.5	0.8	3.0	-0.2	-1.7	0.7	-0.8	0.0	1.1	0.3
Total locomotion distance, hab. session 1	0.5	0.7	2.6	0.2	0.2	-0.6	-1.2	1.6	-0.5	-0.6
Locomotion velocity, hab. session 1	0.3	0.5	1.7	0.5	-0.2	-0.5	-1.3	1.0	-0.1	-0.3
Time in familiar zone, hab. session 2	0.8	0.9	1.9	-1.0	-1.1	0.9	0.9	-1.4	0.6	-0.0
Time in novel zone, hab. session 2	2.9	2.9	7.1	1.2	2.7	-2.0	-0.8	2.3	-1.2	-0.5
Total zone transitions, hab. session 2	0.3	0.4	1.1	0.8	-0.4	-0.5	-1.1	-0.0	-0.2	-0.7
Total locomotion distance, hab. session 2	0.4	0.5	1.7	0.5	0.1	-0.5	-0.8	0.5	-0.7	-1.3
Locomotion velocity, hab. session 2	0.3	0.4	1.5	0.5	0.0	-0.4	-0.7	0.3	-0.7	-1.2
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.3	-0.1	0.4	0.3	-0.2	0.1	0.3
Novelty place preference	0.0	0.0	0.1	-0.1	0.2	0.1	0.2	-0.1	-0.1	0.3
Time in novel zone, NPP test	0.0	0.0	0.2	-0.0	0.4	-0.2	-0.1	0.2	-0.1	0.1
Total zone transitions, NPP test	0.5	0.7	2.0	0.7	-0.7	-0.7	-1.4	-0.2	1.0	0.4
Total locomotion distance, NPP test	0.6	0.8	2.5	0.6	0.4	-1.3	-1.6	0.8	0.5	-0.3
Locomotion velocity, NPP test	0.2	0.3	1.2	0.2	-0.1	-0.7	-1.1	0.3	0.7	0.0
Intraocular pressure	0.9	1.4	3.5	1.9	0.7	-1.3	-1.6	0.5	-0.5	0.8
Delta distance traveled before/after self-admin	3.5	3.7	7.3	1.5	1.0	-1.4	-2.0	1.8	-2.7	-2.5
Delta ambulatory time before/after self-admin	2.6	3.2	7.3	1.4	0.4	-1.0	-1.8	1.1	-2.7	-2.7
Parametrial fat weight	0.2	0.6	1.0	0.8	0.5	-0.6	-1.0	0.8	-0.6	-0.9
Pavlov. Cond. lever latency	1.0	1.3	1.8	1.2	1.3	-1.3	-1.1	1.0	-1.3	-0.3
Pavlov. Cond. magazine entry latency	1.9	2.5	6.6	-2.6	-0.6	1.4	2.4	-1.1	1.1	0.5
Pavlov. Cond. change in total contacts	0.4	0.4	1.2	-1.1	-0.0	0.2	0.9	-0.6	0.7	-0.2
Pavlov. Cond. index score	1.2	1.5	3.1	-1.8	-0.9	1.3	1.7	-1.0	0.9	0.1
Pavlov. Cond. latency score	1.6	2.1	3.5	-1.9	-1.2	1.6	1.8	-1.3	1.3	0.5
Pavlov. Cond. lever contacts	0.7	0.9	1.3	-1.2	-0.9	1.0	1.0	-0.8	1.1	0.2
Pavlov. Cond. magazine entry number	1.7	2.1	6.4	2.5	0.4	-1.2	-2.2	0.8	-1.0	-0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.7	1.1	-0.1	-0.5	-1.3	0.6	-0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.8	-1.7	-0.7	1.2	1.6	-0.9	0.7	0.0
Pavlov. Cond. response bias	0.8	0.9	3.3	-1.8	-0.0	0.6	1.4	-0.2	0.8	0.3
Pavlov. Cond. lever latency	1.2	1.7	3.5	-1.5	-1.5	1.9	1.4	-0.7	0.9	0.4
Pavlov. Cond. magazine entry latency	2.5	3.0	5.7	2.3	1.6	-2.4	-1.8	0.6	-1.5	-1.4
Pavlov. Cond. change in total contacts	2.4	3.9	8.1	2.4	2.2	-2.9	-2.1	1.2	-1.4	-0.9
Pavlov. Cond. index score	2.3	3.0	6.1	2.3	1.7	-2.5	-2.0	0.8	-1.3	-0.8
Pavlov. Cond. latency score	2.6	3.4	6.7	2.4	1.8	-2.6	-2.1	0.9	-1.4	-0.9
Pavlov. Cond. lever contacts	1.0	1.4	2.8	1.5	1.3	-1.7	-1.5	0.6	-0.7	-0.3
Pavlov. Cond. magazine entry number	3.1	3.8	7.8	-2.3	-2.1	2.8	1.9	-1.1	1.5	1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.0	0.2	0.4	0.1	-0.2	0.8	-1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.8	5.9	2.2	1.7	-2.4	-1.9	0.6	-1.2	-0.7
Pavlov. Cond. response bias	1.5	2.1	4.7	1.6	1.8	-2.2	-1.5	0.9	-0.9	-0.5
Time in closed arm before self-admin	1.0	1.3	3.4	0.7	0.4	-0.5	-1.1	1.0	-1.6	-1.9
Time in closed arm after self-admin	1.9	2.0	5.8	1.2	1.3	-1.3	-0.9	0.5	-2.4	-1.6
Time in open arm before self-admin	0.9	1.0	1.6	-0.7	-1.3	0.8	0.7	-1.1	1.3	1.0
Time in open arm after self-admin	1.0	1.1	4.0	-0.1	-1.6	0.8	-0.5	-0.4	2.0	0.7
Bone: periosteal estimation	6.6	14.0	23.2	4.8	3.7	-4.1	-4.3	3.3	-3.7	1.0
Bone: periosteal perimeter	2.6	4.5	9.1	3.0	1.9	-2.1	-2.3	1.3	-2.2	1.5
Bone: post-yield work	3.1	4.6	8.7	2.8	0.9	-1.6	-3.0	2.5	-2.3	-0.3
Progressive ratio test 1 active lever presses	0.7	0.9	2.4	0.8	0.8	-0.9	-1.0	1.5	-0.7	-0.6
Progressive ratio test 1 breakpoint	0.9	1.1	2.6	0.9	0.8	-1.0	-1.2	1.6	-0.7	-0.7
Progressive ratio test 1 inactive lever presses	3.4	4.9	11.0	1.6	2.7	-2.3	-1.7	3.3	-1.9	-1.2
Progressive ratio test 2 active lever presses	1.3	1.5	2.7	1.2	1.4	-1.4	-1.1	1.6	-1.1	-0.4
Progressive ratio test 2 breakpoint	1.4	1.7	2.9	1.2	1.5	-1.4	-1.1	1.7	-1.2	-0.5
Progressive ratio test 2 inactive lever presses	1.4	2.3	4.1	1.2	1.9	-1.9	-1.3	2.0	-1.1	-0.6
Incentive Sensitization - Responses	0.2	0.3	0.8	0.4	0.9	-0.5	0.0	0.5	-0.7	-0.2
Incentive Sensitization - Breakpoint	0.2	0.3	0.8	0.3	0.9	-0.5	0.1	0.5	-0.8	-0.2
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.4	-1.2	0.0	0.4	0.6	0.1	0.5	-0.4
Progressive ratio	0.5	0.8	2.3	1.5	0.5	-1.1	-0.9	-0.8	-0.8	0.1
Food seeking constrained by brief footshock	0.9	1.0	3.3	-1.0	-0.4	0.8	1.4	-1.8	0.3	-0.3
Seeking ratio, punishment vs. effort	0.5	0.7	1.7	-1.3	-0.3	1.0	1.3	-0.4	0.7	-0.2
Retroperitoneal fat weight	0.2	0.9	2.3	-0.1	-0.5	-0.3	-1.5	1.5	0.4	-0.9
Reaction time number correct	0.2	0.4	0.9	0.1	0.9	-0.7	-0.4	0.9	-0.1	0.7
Reaction time mean minus median	0.0	0.1	0.2	-0.4	0.1	0.2	-0.2	0.5	-0.3	0.5
Reaction time mean minus median AUC	0.4	1.1	3.0	0.0	1.7	-0.9	-0.2	1.4	-1.4	0.0
Reaction time num false alarms	0.1	0.1	0.4	0.1	0.3	-0.1	0.1	0.3	-0.6	-0.1
Reaction time num false alarms AUC	0.0	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.3	0.1
Reaction time trials correct on left	0.2	0.4	0.9	0.1	0.9	-0.7	-0.4	0.9	-0.1	0.7
Reaction time trials on left	0.2	0.5	0.9	0.1	1.0	-0.7	-0.5	0.9	-0.1	0.8
Reaction time mean	0.4	0.6	1.4	0.4	0.5	-0.6	-0.9	1.1	-1.2	-0.6
Reaction time mean AUC	0.9	1.4	2.4	0.7	1.0	-1.1	-1.1	1.5	-1.5	-1.0
Median of all reaction times	0.8	1.2	2.3	0.9	0.8	-1.0	-1.1	1.3	-1.5	-1.0
Reaction time omissions	0.3	0.5	1.1	0.4	1.0	-0.9	-0.5	0.3	-1.1	0.3
Reaction time false alarm rate	0.2	0.3	0.7	-0.2	-0.8	0.7	0.6	-0.8	-0.0	0.0
Reaction time premature initiation rate	4.3	6.0	12.8	-2.6	-3.6	3.3	1.7	-2.2	1.9	-0.1
Reaction time premature initiations	1.4	2.5	5.4	-1.9	-2.3	2.2	1.0	-1.1	1.2	-0.0
Std. dev. reaction times	0.0	0.1	0.2	-0.3	0.1	0.0	-0.2	0.3	-0.2	0.5
Reaction time trials completed	0.2	0.5	0.9	0.1	1.0	-0.7	-0.5	0.9	-0.1	0.8
Reaction time trials AUC	0.3	0.5	1.1	0.2	1.1	-0.8	-0.6	1.0	-0.2	0.7
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.7	-0.6	0.5	0.7	-0.3	0.5	-0.2
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.0	0.0	-0.1	-0.3
Latency to leave start box in cocaine runway	0.6	0.7	1.4	-1.0	1.0	-0.0	0.9	0.6	-0.5	-1.2
Latency to leave start box in cocaine runway, F	0.5	0.6	2.1	-1.4	0.5	0.3	0.9	0.8	0.3	-0.5
Latency to leave start box in cocaine runway, M	1.6	1.5	4.2	0.5	1.5	-0.8	0.1	0.4	-2.0	-1.8
Std. dev. time between licks in bursts	1.9	2.6	4.9	1.7	1.1	-2.0	-2.2	1.2	-1.0	-1.7
Total sessions with >9 infusions	1.1	1.3	4.0	0.4	1.5	-0.9	-0.3	2.0	-1.0	-0.7
Short access day 1 total inactive lever presses	4.0	5.2	8.3	2.1	2.5	-2.6	-2.1	2.9	-2.1	-1.5
Short access day 10 total inactive lever presses	0.4	1.0	2.1	1.2	0.8	-1.2	-1.4	1.1	-0.3	0.0
Short access day 1 total infusions	2.8	3.7	8.5	1.1	2.9	-2.2	-0.8	2.4	-1.9	-1.0
Short access day 10 total infusions	4.8	6.2	11.0	1.6	2.3	-2.3	-1.8	3.3	-3.0	-2.6
Short access total infusions	5.3	6.7	10.9	2.1	3.0	-2.8	-2.0	3.3	-2.7	-1.8
Short access day 1 locomotion	1.2	1.5	4.2	0.5	1.2	-0.9	-0.7	2.1	-1.3	-1.1
Short access day 10 total locomotion	0.4	0.8	1.4	1.2	0.3	-0.5	-1.1	1.2	-1.0	-0.4
Short access total locomotion	0.9	1.1	3.3	0.6	1.0	-0.7	-0.6	1.8	-1.1	-0.9
One hour access (0.3 mA shock)	1.2	1.4	2.8	1.1	1.4	-1.2	-0.9	1.7	-1.2	-0.3
Compulsive drug intake	1.1	1.3	2.7	1.6	1.0	-1.3	-1.6	0.8	-0.6	-0.1
One hour access (shock baseline)	0.2	0.3	0.7	0.4	0.5	-0.4	-0.2	0.7	-0.8	-0.3
Social response proportion	0.2	0.3	0.8	-0.9	0.2	0.4	0.5	0.3	-0.5	0.5
Social responses	0.7	0.9	2.6	-1.1	1.2	-0.2	0.5	1.6	-0.7	-0.2
Social time	0.7	0.9	2.7	0.1	0.8	-0.4	-0.6	1.6	-1.4	-0.6
Soleus weight	0.4	1.1	3.9	1.3	0.5	-0.5	-0.5	0.2	-2.0	-1.2
Bone: stiffness	4.3	7.0	9.5	2.6	3.1	-3.1	-2.6	2.9	-2.8	-0.5
Tibialis anterior weight	0.1	0.4	1.3	-0.2	0.5	-0.1	0.4	0.5	-1.1	-0.8
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.8	1.4	-0.0	-0.7	-1.3	0.1	0.1	0.2
Time to tail flick, vehicle, after self-admin	0.8	1.1	2.3	-1.2	-0.8	1.4	1.5	-1.0	-0.0	-0.1
Time to tail flick, test, before self-admin	2.1	2.1	5.0	-0.5	-2.2	1.2	0.3	-2.2	1.5	0.9
Time to tail flick, test, after self-admin	3.1	3.2	4.9	-1.3	-2.1	1.6	1.4	-2.2	2.2	1.5
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	4.5	-2.1	-0.9	1.7	2.0	-0.7	0.2	-0.4
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	-0.4	0.3	0.1	0.9	-0.2	0.8	0.8
Tibia length	0.4	1.1	3.2	-1.3	1.2	0.3	1.8	-0.5	0.5	0.9
Ambulatory time before self-admin	1.4	2.0	4.6	-2.1	-0.6	1.5	2.1	-0.8	1.1	0.9
Ambulatory time after self-admin	0.2	0.2	0.9	-0.2	-0.5	0.4	-0.0	-0.3	-0.5	-1.0
Bone: tissue strength	1.9	1.9	5.4	-0.4	2.1	-1.3	-0.3	2.3	-0.4	-1.3
Total heroin consumption	0.5	0.6	2.5	-0.2	0.0	0.3	1.0	-1.6	0.2	-0.5
Bone: trabecular number	0.3	0.6	2.7	-0.3	0.8	0.0	0.5	-0.4	0.4	1.7
Bone: trabecular spacing	0.2	0.3	1.7	0.1	0.1	-0.2	-0.0	0.4	-0.2	-1.3
Bone: trabecular thickness	0.4	0.5	2.1	0.2	-0.3	0.2	-0.2	-0.8	0.6	1.4
Bone: trabecular tissue density	0.6	0.8	3.2	-0.1	-1.8	1.1	-0.4	-0.6	0.8	0.5
Water consumed over 24 hours	0.7	0.9	2.1	-0.0	-1.5	0.9	-0.3	-0.7	0.8	1.4
Number of responses in last shaping day	2.5	2.7	4.5	1.8	1.2	-1.4	-1.8	2.1	-1.9	-1.0