Hub : Genes

LOC134479954

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC134479954 0.22 0.13 1.1e-03 0.09 0.12 0.12 0.12 4.2e-03 8.3e-04 7.4e-04 1.1e-03
2 Brain gene expression LOC134479954 0.14 0.08 1.4e-08 0.08 0.1 0.09 0.1 1.0e-07 1.7e-09 8.4e-09 2.5e-09
3 PL gene expression LOC134479954 0.04 0.03 1.9e-04 0.02 0.03 0.03 0.02 1.4e-03 5.1e-04 3.9e-04 1.5e-03
4 IC gene expression LOC134479954 0.07 0.06 2.3e-03 0.06 0.06 0.03 0.05 1.5e-03 2.5e-03 2.2e-02 2.8e-03
5 Liver gene expression LOC134479954 0.1 0.06 1.3e-09 0.06 0.05 0.04 0.06 1.8e-07 3.3e-06 8.1e-06 7.7e-07
6 NAcc gene expression LOC134479954 0.01 0.01 7.6e-03 0.01 0 -0 0 4.9e-03 1.1e-01 9.0e-01 7.3e-02
7 pVTA gene expression LOC134479954 0.21 0.16 7.3e-04 0.04 0.04 0.04 0.04 1.7e-04 6.9e-04 3.6e-04 3.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.52.53.71.61.41.51.51.51.51.9
Area under the delay curve0.50.51.1-0.10.30.50.90.91.10.8
BMI with tail5.218.120.4-4.5-4.4-4.4-3.9-3.9-4.1-4.3
BMI without tail2.37.28.7-2.3-2.5-2.6-2.7-2.7-2.8-2.9
Body weight2.19.110.0-3.1-3.1-3.2-2.9-2.9-3.0-3.0
Weight adjusted by age2.94.36.0-2.4-2.4-2.2-1.9-1.9-1.8-1.9
Bone surface0.91.72.50.70.80.91.61.61.61.5
Bone volume1.32.43.31.11.11.31.71.71.71.8
Breakpoint value in progressive ratio session0.20.20.4-0.6-0.6-0.4-0.4-0.4-0.4-0.2
Number of licking bursts0.10.10.40.20.40.10.10.10.00.6
Context. condit. distance diff. score2.12.54.8-1.2-1.3-1.4-1.6-1.6-1.6-2.2
Locomotion velocity, session 10.20.20.2-0.5-0.4-0.4-0.4-0.4-0.30.5
Locomotion distance, session 12.22.83.51.31.61.61.91.91.71.8
Locomotion velocity, session 20.70.81.0-1.0-0.9-1.0-0.9-0.9-0.9-0.3
Locomotion distance, session 21.11.52.50.91.11.01.41.41.21.6
Locomotion velocity, session 30.20.20.50.70.70.1-0.4-0.4-0.4-0.5
Locomotion distance, session 30.10.10.40.30.40.20.10.10.1-0.6
Stereotopy head waving bouts, day 31.51.82.60.91.11.21.61.61.61.2
Stereotopy head waving duration, day 30.81.01.21.00.91.01.01.01.01.1
Locomotion velocity, session 71.01.11.9-0.5-0.8-0.7-1.4-1.4-1.4-1.0
Locomotion distance, session 70.30.40.7-0.3-0.4-0.3-0.8-0.8-0.8-0.2
Stereotopy head waving bouts, day 71.51.72.21.51.41.41.41.41.30.7
Stereotopy head waving duration, day 71.51.82.91.71.61.41.31.31.20.5
Locomotion velocity, session 80.91.11.8-0.5-0.9-0.9-1.3-1.3-1.3-0.7
Locomotion distance, session 80.71.01.7-1.1-1.0-1.2-0.7-0.7-0.8-1.3
Degree of sensitization distance1.41.52.3-1.4-1.5-1.2-1.2-1.2-1.2-0.2
Degree of sensitization stereotypy0.50.51.21.11.00.80.60.60.50.2
Conditioned locomotion0.60.71.2-0.7-0.5-0.8-0.9-0.9-0.9-1.1
Cocaine response after cond. corrected1.01.31.6-0.8-1.1-1.1-1.2-1.2-1.2-1.0
Cocaine response after cond. not corrected2.52.93.4-1.3-1.6-1.7-1.8-1.8-1.8-1.7
Cocaine response before conditioning1.11.31.5-1.1-1.1-1.2-1.1-1.1-1.1-1.2
Saline control response1.11.42.7-1.7-1.4-1.5-0.7-0.7-0.7-1.4
Bone: connectivity density1.21.93.21.51.41.31.21.21.21.8
Bone: cortical apparent density2.02.83.81.61.91.61.81.81.80.9
Bone: cortical area1.42.14.8-2.2-1.8-1.8-0.8-0.8-0.8-1.3
Bone: cortical porosity0.50.51.4-1.2-1.0-0.9-0.4-0.4-0.40.2
Bone: cortical porosity0.91.02.2-1.5-1.4-1.2-0.6-0.6-0.6-0.1
Bone: cortical thickness0.20.41.0-1.0-0.8-0.8-0.2-0.2-0.2-0.5
Bone: cortical thickness1.11.21.8-0.7-1.3-0.6-1.2-1.2-1.2-1.2
Bone: cortical tissue density1.92.53.51.61.91.61.71.71.70.8
Condit. Reinf. active minus inactive responses3.23.66.4-2.2-1.9-2.1-1.4-1.4-1.3-2.5
Condit. Reinf. active-inactive response ratio0.70.72.5-0.9-0.6-1.0-0.4-0.4-0.4-1.6
Condit. Reinf. active responses3.94.96.7-2.6-2.2-2.5-1.8-1.8-1.8-2.6
Condit. Reinf. inactive responses1.92.43.4-1.8-1.7-1.7-1.4-1.4-1.5-1.2
Incentive salience index mean4.55.68.3-2.9-2.5-2.7-1.8-1.8-1.8-2.8
Condit. Reinf. lever presses3.14.36.9-2.6-2.2-2.5-1.6-1.6-1.7-2.0
Condit. Reinf. active minus inactive responses0.10.20.6-0.6-0.80.10.20.20.30.0
Condit. Reinf. active-inactive response ratio0.10.10.3-0.4-0.5-0.0-0.1-0.10.1-0.3
Condit. Reinf. active responses0.60.82.4-1.4-1.6-0.7-0.5-0.5-0.4-0.5
Condit. Reinf. inactive responses0.70.91.7-1.3-1.3-1.0-0.7-0.7-0.9-0.5
Condit. Reinf. lever presses1.92.74.6-2.1-2.1-1.8-1.2-1.2-1.2-1.5
Condit. Reinf. lever reinforcers received0.50.72.0-1.4-1.4-0.7-0.3-0.3-0.2-0.3
Conditioned reinforcement - actives0.40.71.4-1.0-1.2-0.8-0.8-0.8-0.7-0.1
Conditioned reinforcement - inactives0.10.20.3-0.1-0.4-0.0-0.6-0.6-0.5-0.1
Conditioned locomotion2.33.04.1-1.7-2.0-1.6-1.9-1.9-1.8-1.3
Patch foraging indifference point 0 sec0.50.91.3-1.0-1.1-1.0-0.8-0.8-0.8-1.1
Patch foraging indifference point AUC0.40.51.2-0.4-0.10.21.01.01.10.6
Delay disc. indifference point, 0s delay1.21.33.9-2.0-1.5-1.4-0.6-0.6-0.6-0.3
Delay disc. indifference point, 16s delay0.10.10.2-0.20.00.10.40.40.40.3
Delay disc. indifference point, 2s delay1.92.24.1-0.10.30.91.81.81.92.0
Delay disc. indifference point, 24s delay0.91.02.1-0.9-0.9-1.0-0.9-0.9-0.6-1.5
Delay disc. indifference point, 4s delay0.80.81.6-0.00.60.51.31.31.10.8
Delay disc. indifference point, 8s delay0.80.91.60.60.91.01.11.11.30.6
Indifference point function ln k2.03.44.4-1.4-1.7-1.6-2.0-2.0-2.0-2.1
Indifference point function log k2.03.44.4-1.4-1.7-1.6-2.0-2.0-2.0-2.1
Patch foraging total patch changes 0 sec0.20.40.8-0.6-0.8-0.7-0.5-0.5-0.5-0.9
Patch foraging total patch changes 12 sec0.30.31.0-1.0-0.9-0.70.00.00.2-0.3
Patch foraging total patch changes 18 sec0.91.41.90.70.51.31.31.31.31.4
Patch foraging total patch changes 24 sec0.10.10.20.1-0.10.50.50.50.40.3
Patch foraging total patch changes 6 sec0.10.20.4-0.5-0.3-0.30.60.60.60.0
Patch foraging time to switch 0 sec0.51.03.31.10.91.00.60.60.51.8
Patch foraging water rate 0 sec0.91.95.6-1.1-1.1-1.2-1.1-1.1-1.2-2.4
Patch foraging water rate 12 sec1.93.96.7-1.8-1.9-1.9-1.8-1.8-1.8-2.6
Patch foraging water rate 18 sec3.04.77.8-1.4-1.9-1.9-2.3-2.3-2.4-2.8
Patch foraging water rate 24 sec0.71.02.3-0.4-0.7-0.9-1.0-1.0-1.1-1.5
Patch foraging water rate 6 sec0.71.02.1-0.8-0.8-0.9-0.9-0.9-1.0-1.5
Seeking ratio, delayed vs. immediate footshock0.81.01.41.21.11.10.80.80.81.2
Distance traveled before self-admin1.21.62.20.81.31.01.51.51.21.4
Distance traveled after self-admin0.10.20.40.40.60.40.10.1-0.00.6
Extensor digitorum longus weight0.62.34.7-1.2-1.3-1.4-1.3-1.3-1.5-2.2
Bone: elastic displacement0.60.60.90.80.80.51.01.00.90.5
Bone: elastic work0.20.30.4-0.6-0.7-0.6-0.3-0.3-0.4-0.5
Bone: endosteal estimation0.40.81.7-1.3-1.1-1.0-0.5-0.5-0.6-1.1
Bone: endosteal perimeter1.32.77.7-2.8-2.3-1.9-0.6-0.6-0.7-1.2
Epididymis fat weight2.58.712.7-3.6-3.5-3.2-2.7-2.7-2.7-1.9
Delta time in closed arm before/after self-admin0.10.10.3-0.1-0.30.10.10.10.20.5
Delta time in open arm before/after self-admin0.00.00.1-0.10.1-0.20.00.0-0.00.0
Diff in mean of infusions in LGA sessions1.61.93.4-1.8-1.9-1.5-1.1-1.1-1.0-1.0
Delay discount exponential model param0.40.51.0-0.1-0.4-0.6-0.9-0.9-1.0-0.7
Extinction: sum of active levers before priming0.10.10.2-0.10.10.20.50.50.50.4
Active lever presses in extinction session 62.02.02.6-1.2-1.5-1.2-1.6-1.6-1.6-0.9
Bone: final force0.10.10.5-0.7-0.5-0.4-0.0-0.00.10.2
Bone: final moment0.10.10.2-0.4-0.2-0.20.30.30.30.4
Food consumed during 24 hour testing period2.94.07.1-1.8-1.8-2.1-1.8-1.8-1.8-2.7
Glucose0.10.20.4-0.10.00.20.60.60.6-0.2
Heart weight0.40.71.7-0.4-0.6-0.7-0.8-0.8-1.0-1.3
Delay discount hyperbolic model param0.70.81.5-0.2-0.5-0.7-1.1-1.1-1.2-0.9
Intermittent access intake day 1-15 change0.40.91.5-0.9-1.2-0.8-0.9-0.9-1.0-0.6
Intermittent access intake escalation0.51.01.7-1.0-1.3-0.9-1.0-1.0-1.0-0.6
Intermittent access intake escalation 21.82.03.9-1.7-2.0-1.4-1.3-1.3-1.3-0.5
Intermitt. access day 1 inactive lever presses0.20.71.3-1.0-1.1-0.7-0.8-0.8-0.8-0.2
Intermitt. access day 15 inactive lever presses1.32.74.3-0.8-1.3-1.2-2.0-2.0-2.1-1.6
Intermitt. access escalation Index0.30.40.70.80.80.60.50.50.50.7
Intermittent access day 1 total infusions0.00.00.10.30.10.2-0.2-0.2-0.2-0.1
Intermittent access day 15 total infusions0.10.10.3-0.1-0.5-0.1-0.5-0.5-0.50.0
Intermittent access terminal intake (last 3 days)1.01.32.3-1.1-1.5-1.0-1.2-1.2-1.2-0.5
Intermittent access total infusions0.10.10.3-0.2-0.5-0.2-0.5-0.5-0.40.1
Intermittent access day 1 locomotion0.00.00.0-0.1-0.10.20.00.00.0-0.2
Intermittent access day 15 total locomotion0.61.11.7-1.1-1.3-0.9-1.0-1.0-1.0-0.9
Intermittent access total locomotion0.70.91.4-0.8-1.0-0.7-0.9-0.9-1.0-1.2
Intermittent access standard deviation0.10.30.60.0-0.3-0.2-0.7-0.7-0.80.1
Left kidney weight4.721.925.9-4.8-5.0-5.1-4.6-4.6-4.7-3.8
Right kidney weight7.333.038.3-5.7-6.0-6.2-5.8-5.8-5.8-4.9
Cocaine induced anxiety1.01.41.9-1.0-0.8-1.4-1.2-1.2-1.2-1.4
Post-drug Anxiety1.81.94.2-1.1-0.8-1.5-1.3-1.3-1.3-2.1
Baseline Anxiety0.40.50.70.80.80.80.70.70.60.3
Tail length0.62.43.11.71.61.61.41.41.31.8
Length with tail0.00.00.1-0.10.10.00.20.20.20.3
Length without tail0.31.02.4-1.5-1.3-1.3-0.6-0.6-0.6-0.7
Times rat made contact with spout0.70.81.30.5-0.1-0.2-1.1-1.1-1.1-1.2
Lifetime Intake0.10.20.3-0.2-0.5-0.2-0.6-0.6-0.50.2
Liver weight, left0.40.61.7-1.3-1.0-1.0-0.3-0.3-0.4-0.6
Liver weight, right0.10.10.30.00.10.20.50.50.50.3
Locomotor activity0.40.61.7-1.3-1.1-1.1-0.2-0.2-0.3-0.1
Locomotor testing distance0.61.21.60.80.90.91.21.21.11.2
Locomotor testing rearing0.30.61.0-0.8-0.50.01.01.00.90.8
Locomotion in novel chamber0.81.02.10.3-0.5-0.4-1.4-1.4-1.5-0.4
Locomotion in novel chamber post-restriction0.00.10.20.1-0.10.30.20.20.30.5
Fecal boli incidents, locomotor time 10.30.40.70.70.70.60.70.70.8-0.0
Change in fecal boli incidents, locomotor task0.40.40.6-0.7-0.8-0.7-0.7-0.7-0.5-0.3
Time >=10cm from walls, locomotor time 10.50.51.1-1.1-0.8-1.0-0.5-0.5-0.6-0.4
Bouts of movement, locomotor time 10.30.40.70.2-0.6-0.2-0.8-0.8-0.7-0.6
Total resting periods, locomotor time 10.10.10.40.6-0.10.2-0.4-0.4-0.2-0.4
Rest time, locomotor task time 10.40.52.11.40.60.9-0.1-0.10.00.7
Distance moved, locomotor task time 10.50.72.1-1.4-0.9-1.1-0.3-0.3-0.4-0.6
Vertical activity count, locomotor time 10.92.14.7-2.2-1.8-1.8-1.0-1.0-0.9-0.9
Time >=10cm from walls, locomotor time 21.92.83.7-1.9-1.9-1.9-1.6-1.6-1.4-1.2
Bouts of movement, locomotor time 20.30.40.80.90.70.80.50.50.60.5
Total resting periods, locomotor time 20.30.40.70.90.60.80.60.60.60.5
Rest time, locomotor task time 21.11.42.81.71.51.30.90.90.81.0
Distance moved, locomotor task time 22.53.04.8-2.2-2.1-1.8-1.5-1.5-1.3-1.6
Vertical activity count, locomotor time 22.53.45.2-2.3-2.3-1.9-1.7-1.7-1.4-1.7
Light reinforcement 10.30.81.6-1.2-1.2-1.1-0.6-0.6-0.8-0.6
Light reinforcement 22.53.96.4-2.5-2.4-2.1-1.7-1.7-1.7-1.4
Bone: marrow area0.30.61.4-1.2-1.0-0.9-0.3-0.3-0.4-0.9
Bone: maximum diameter2.44.58.2-2.9-2.3-2.4-1.6-1.6-1.6-2.2
Bone: maximum force0.10.10.4-0.6-0.5-0.5-0.1-0.1-0.1-0.1
Bone: maximum moment0.00.00.1-0.3-0.2-0.20.20.20.20.2
Mean time between licks in bursts1.63.95.42.32.32.11.71.71.71.7
Mean num. licks in bursts0.20.21.20.3-0.20.1-0.4-0.4-0.3-1.1
Cd content in liver0.50.50.80.60.50.90.80.80.80.4
Co content in liver0.20.30.6-0.8-0.6-0.8-0.2-0.2-0.20.5
Cu content in liver0.70.82.21.51.31.20.20.20.30.5
Fe content in liver0.10.10.2-0.2-0.00.10.40.40.40.4
K content in liver0.20.20.30.30.50.30.30.30.30.6
Mg content in liver1.11.11.60.50.90.71.21.21.31.2
Mn content in liver0.10.20.9-0.00.10.00.20.20.21.0
Na content in liver3.33.64.91.51.52.22.02.02.01.8
Rb content in liver0.10.10.3-0.5-0.3-0.40.20.20.3-0.3
Se content in liver0.10.10.20.0-0.2-0.3-0.5-0.5-0.4-0.2
Sr content in liver1.61.42.21.41.51.31.01.01.00.8
Zn content in liver0.91.02.11.31.51.00.80.80.70.6
Bone: minimum diameter0.81.53.3-1.8-1.6-1.4-0.8-0.8-0.7-0.8
Time in familiar zone, hab. session 10.10.10.20.40.2-0.1-0.4-0.4-0.30.2
Time in novel zone, hab. session 10.40.40.70.20.30.50.90.90.80.6
Total zone transitions, hab. session 12.73.74.41.81.92.02.12.11.91.7
Total locomotion distance, hab. session 10.20.30.80.10.40.30.90.90.60.5
Locomotion velocity, hab. session 10.30.40.9-0.10.40.21.01.00.70.4
Time in familiar zone, hab. session 21.61.72.4-0.8-1.0-1.2-1.5-1.5-1.5-1.3
Time in novel zone, hab. session 22.22.32.91.31.41.51.71.71.71.2
Total zone transitions, hab. session 20.00.10.1-0.1-0.1-0.2-0.2-0.2-0.3-0.3
Total locomotion distance, hab. session 20.60.81.4-1.0-0.9-1.2-0.8-0.8-0.9-0.6
Locomotion velocity, hab. session 20.60.81.5-1.1-0.9-1.2-0.7-0.7-0.8-0.6
Novel to familiar place preference ratio0.30.30.90.91.00.50.30.30.2-0.3
Novelty place preference0.20.20.80.80.90.40.20.20.1-0.3
Time in novel zone, NPP test0.40.41.11.01.10.50.20.20.2-0.3
Total zone transitions, NPP test0.81.11.41.21.11.11.11.11.10.6
Total locomotion distance, NPP test0.10.10.1-0.3-0.1-0.20.40.40.3-0.1
Locomotion velocity, NPP test0.00.10.2-0.4-0.2-0.30.20.20.10.0
Intraocular pressure0.30.51.4-1.2-1.0-0.7-0.1-0.1-0.1-0.6
Delta distance traveled before/after self-admin2.93.04.8-0.9-1.4-1.4-2.2-2.2-2.2-1.5
Delta ambulatory time before/after self-admin1.92.33.5-0.8-1.1-1.2-1.8-1.8-1.7-1.9
Parametrial fat weight0.41.01.7-1.3-1.2-0.9-1.0-1.0-1.0-0.2
Pavlov. Cond. lever latency2.32.94.72.21.92.01.51.51.41.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.5-0.2-0.30.10.10.1-0.6
Pavlov. Cond. change in total contacts0.70.82.2-1.5-1.0-1.0-0.3-0.3-0.4-0.9
Pavlov. Cond. index score0.40.51.2-1.1-0.8-0.9-0.5-0.5-0.5-0.7
Pavlov. Cond. latency score0.70.91.9-1.4-1.1-1.1-0.7-0.7-0.7-0.9
Pavlov. Cond. lever contacts2.22.64.3-2.1-1.8-1.9-1.4-1.4-1.4-1.1
Pavlov. Cond. magazine entry number0.10.10.40.50.20.3-0.2-0.2-0.30.7
Pavlov. Cond. intertrial magazine entries1.51.82.5-1.5-1.6-1.4-1.2-1.2-1.2-1.3
Pavlov. Cond. lever-magazine prob. diff.0.30.30.9-1.0-0.7-0.7-0.3-0.3-0.3-0.6
Pavlov. Cond. response bias0.80.91.6-1.3-1.1-1.1-0.7-0.7-0.6-1.1
Pavlov. Cond. lever latency1.92.63.01.61.71.71.61.61.61.5
Pavlov. Cond. magazine entry latency1.41.72.7-1.5-1.2-1.3-1.2-1.2-1.2-1.6
Pavlov. Cond. change in total contacts0.40.61.5-1.2-1.1-0.7-0.4-0.4-0.4-0.7
Pavlov. Cond. index score1.52.02.7-1.6-1.5-1.5-1.3-1.3-1.2-1.4
Pavlov. Cond. latency score2.23.03.5-1.9-1.8-1.8-1.6-1.6-1.6-1.8
Pavlov. Cond. lever contacts2.02.73.1-1.6-1.8-1.6-1.6-1.6-1.6-1.7
Pavlov. Cond. magazine entry number1.82.23.01.71.51.51.31.31.31.6
Pavlov. Cond. intertrial magazine entries0.40.61.41.20.80.80.40.40.31.1
Pavlov. Cond. lever-magazine prob. diff.1.62.22.9-1.7-1.5-1.6-1.3-1.3-1.3-1.5
Pavlov. Cond. response bias0.91.21.7-1.3-1.2-1.2-1.0-1.0-1.0-1.0
Time in closed arm before self-admin0.30.41.0-0.30.30.30.70.71.00.8
Time in closed arm after self-admin0.30.40.8-0.9-0.7-0.20.30.30.50.9
Time in open arm before self-admin0.20.20.60.80.50.70.00.00.1-0.0
Time in open arm after self-admin0.10.10.30.10.1-0.1-0.2-0.2-0.2-0.6
Bone: periosteal estimation1.02.14.7-2.2-1.8-1.7-0.8-0.8-0.8-1.4
Bone: periosteal perimeter2.13.68.1-2.8-2.4-2.2-1.1-1.1-1.1-1.5
Bone: post-yield work0.71.11.41.11.21.10.90.90.91.0
Progressive ratio test 1 active lever presses0.10.10.50.70.50.4-0.2-0.2-0.20.1
Progressive ratio test 1 breakpoint0.10.20.60.70.50.5-0.1-0.1-0.10.2
Progressive ratio test 1 inactive lever presses0.10.10.1-0.3-0.3-0.1-0.4-0.4-0.30.1
Progressive ratio test 2 active lever presses0.60.71.1-0.6-1.0-0.7-1.0-1.0-1.1-0.4
Progressive ratio test 2 breakpoint0.40.50.8-0.4-0.8-0.5-0.8-0.8-0.9-0.2
Progressive ratio test 2 inactive lever presses0.50.91.4-0.9-1.2-0.9-0.9-0.9-1.1-0.6
Incentive Sensitization - Responses1.01.52.6-1.4-1.6-1.3-1.1-1.1-1.2-0.6
Incentive Sensitization - Breakpoint1.01.32.4-1.4-1.5-1.3-1.0-1.0-1.1-0.6
Sum of active levers in priming session hrs 5-60.20.10.4-0.3-0.3-0.2-0.4-0.4-0.30.6
Progressive ratio0.10.20.4-0.3-0.3-0.4-0.6-0.6-0.70.2
Food seeking constrained by brief footshock2.63.24.2-1.8-2.0-2.1-1.8-1.8-1.9-1.0
Seeking ratio, punishment vs. effort0.10.20.5-0.7-0.6-0.60.00.00.0-0.5
Retroperitoneal fat weight2.812.116.4-4.1-3.9-3.7-3.3-3.3-3.2-2.6
Reaction time number correct0.40.81.00.91.01.01.01.00.80.3
Reaction time mean minus median0.20.40.9-0.9-0.5-0.9-0.3-0.3-0.2-0.9
Reaction time mean minus median AUC0.10.30.8-0.5-0.4-0.7-0.3-0.3-0.2-0.9
Reaction time num false alarms0.00.10.20.20.20.30.20.20.30.4
Reaction time num false alarms AUC0.00.00.10.30.10.2-0.1-0.1-0.0-0.1
Reaction time trials correct on left0.40.81.00.91.01.01.01.00.80.3
Reaction time trials on left0.40.81.11.01.01.01.01.00.80.3
Reaction time mean0.10.20.60.80.70.4-0.0-0.00.1-0.1
Reaction time mean AUC0.20.30.80.90.80.50.10.10.20.0
Median of all reaction times0.30.51.61.31.10.8-0.0-0.00.00.1
Reaction time omissions0.20.30.91.00.60.60.40.40.50.3
Reaction time false alarm rate0.10.10.2-0.2-0.4-0.2-0.4-0.4-0.3-0.0
Reaction time premature initiation rate3.75.28.9-3.0-2.9-2.6-1.8-1.8-1.7-1.8
Reaction time premature initiations1.22.13.8-1.9-1.9-1.6-1.0-1.0-0.9-1.5
Std. dev. reaction times0.20.30.7-0.4-0.3-0.7-0.5-0.5-0.4-0.8
Reaction time trials completed0.40.81.11.01.01.01.01.00.80.3
Reaction time trials AUC0.30.50.70.70.80.80.80.80.60.0
Run reversals in cocaine runway, females0.00.00.10.30.10.0-0.2-0.2-0.0-0.1
Run reversals in cocaine runway, males0.60.61.00.30.50.61.01.01.00.3
Latency to leave start box in cocaine runway1.61.82.5-0.9-1.1-1.2-1.6-1.6-1.5-1.3
Latency to leave start box in cocaine runway, F2.93.35.0-0.7-1.2-1.5-2.2-2.2-2.1-2.2
Latency to leave start box in cocaine runway, M0.20.20.6-0.7-0.5-0.30.20.20.20.8
Std. dev. time between licks in bursts0.70.92.0-1.4-1.3-1.2-0.6-0.6-0.7-0.2
Total sessions with >9 infusions0.20.20.40.1-0.2-0.0-0.7-0.7-0.60.2
Short access day 1 total inactive lever presses4.05.36.1-1.9-2.1-2.3-2.4-2.4-2.4-2.5
Short access day 10 total inactive lever presses3.79.111.7-3.3-3.4-3.2-2.9-2.9-2.9-2.5
Short access day 1 total infusions0.70.91.7-0.3-0.8-0.6-1.3-1.3-1.2-0.7
Short access day 10 total infusions0.60.81.3-0.5-0.9-0.6-1.2-1.2-1.1-0.2
Short access total infusions0.40.61.1-0.4-0.8-0.5-1.0-1.0-1.0-0.1
Short access day 1 locomotion0.60.81.5-0.2-0.7-0.4-1.2-1.2-1.2-0.4
Short access day 10 total locomotion0.61.01.4-0.8-1.1-0.9-1.2-1.2-1.2-0.7
Short access total locomotion0.40.50.8-0.4-0.8-0.4-0.9-0.9-0.9-0.1
One hour access (0.3 mA shock)0.70.81.6-1.1-1.3-0.8-0.9-0.9-0.90.1
Compulsive drug intake0.10.10.6-0.2-0.1-0.10.10.10.1-0.7
One hour access (shock baseline)0.30.51.0-0.5-1.0-0.4-0.7-0.7-0.70.7
Social response proportion0.10.10.2-0.3-0.1-0.10.40.40.3-0.0
Social responses0.10.10.2-0.5-0.3-0.30.30.30.1-0.0
Social time0.40.51.2-0.1-0.2-0.6-0.7-0.7-0.8-1.1
Soleus weight1.13.13.9-1.5-1.7-1.7-1.9-1.9-2.0-1.6
Bone: stiffness0.00.10.10.10.30.20.20.20.30.4
Tibialis anterior weight0.10.20.5-0.1-0.4-0.2-0.4-0.4-0.7-0.5
Time to tail flick, vehicle, before self-admin1.92.03.0-1.7-1.7-1.6-1.2-1.2-1.3-1.2
Time to tail flick, vehicle, after self-admin0.70.91.2-1.0-1.1-0.9-1.0-1.0-0.9-0.9
Time to tail flick, test, before self-admin0.50.50.8-0.8-0.8-0.6-0.9-0.9-0.80.3
Time to tail flick, test, after self-admin3.03.14.9-1.1-1.6-1.5-2.2-2.2-2.0-1.3
Delta time to tail flick, vehicle, before/after SA0.70.71.41.20.91.00.70.70.80.2
Delta time to tail flick, test, before/after SA0.30.31.2-0.0-0.2-0.4-0.4-0.4-0.4-1.1
Tibia length1.33.65.01.91.82.21.91.91.81.7
Ambulatory time before self-admin0.40.60.90.61.00.60.80.80.51.0
Ambulatory time after self-admin0.10.10.30.00.2-0.2-0.4-0.4-0.6-0.4
Bone: tissue strength2.72.74.32.11.91.61.41.41.51.6
Total heroin consumption0.10.10.3-0.3-0.5-0.2-0.2-0.2-0.3-0.2
Bone: trabecular number1.32.13.01.71.41.51.31.31.31.7
Bone: trabecular spacing2.12.83.4-1.8-1.7-1.8-1.7-1.7-1.7-1.3
Bone: trabecular thickness0.10.20.7-0.2-0.30.10.30.30.30.8
Bone: trabecular tissue density1.21.82.11.11.41.51.41.41.41.3
Water consumed over 24 hours0.10.10.2-0.3-0.3-0.5-0.4-0.4-0.3-0.5
Number of responses in last shaping day0.60.61.51.20.71.00.30.30.31.1