LOC134479579

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC134479579 0.06 0.04 1.6e-04 0.02 0.02 0.04 0.03 5.8e-03 1.4e-03 5.9e-05 6.9e-04
2 Liver alternative TSS XR_010053110.1 0.08 0.06 2.6e-03 0.03 0.01 0.01 0.02 4.0e-04 9.1e-03 8.0e-03 1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density6.511.211.3-3.43.3
Area under the delay curve0.60.71.0-1.00.6
BMI with tail3.411.611.7-3.43.4
BMI without tail2.47.39.6-3.12.2
Body weight6.026.229.8-5.54.8
Weight adjusted by age0.20.40.6-0.3-0.8
Bone surface8.715.916.7-4.13.9
Bone volume7.613.614.6-3.83.5
Breakpoint value in progressive ratio session0.50.60.90.41.0
Number of licking bursts1.83.03.21.7-1.8
Context. condit. distance diff. score1.82.22.7-1.71.3
Locomotion velocity, session 14.14.45.72.4-1.7
Locomotion distance, session 13.84.85.72.4-2.0
Locomotion velocity, session 20.80.91.71.3-0.4
Locomotion distance, session 25.27.210.03.2-2.1
Locomotion velocity, session 31.92.12.71.6-1.2
Locomotion distance, session 30.10.10.1-0.30.4
Stereotopy head waving bouts, day 32.12.43.21.3-1.8
Stereotopy head waving duration, day 31.41.71.71.3-1.3
Locomotion velocity, session 70.20.20.40.7-0.1
Locomotion distance, session 71.11.42.61.6-0.4
Stereotopy head waving bouts, day 70.40.40.5-0.7-0.6
Stereotopy head waving duration, day 70.30.30.4-0.7-0.4
Locomotion velocity, session 80.10.10.20.0-0.4
Locomotion distance, session 80.30.50.80.9-0.3
Degree of sensitization distance1.01.01.61.3-0.7
Degree of sensitization stereotypy0.40.40.9-0.9-0.2
Conditioned locomotion0.00.00.00.1-0.0
Cocaine response after cond. corrected0.40.40.80.2-0.9
Cocaine response after cond. not corrected0.20.20.40.1-0.6
Cocaine response before conditioning0.10.20.30.50.1
Saline control response0.91.21.8-1.30.8
Bone: connectivity density4.06.26.4-2.42.5
Bone: cortical apparent density1.62.23.80.7-1.9
Bone: cortical area5.48.39.0-3.02.8
Bone: cortical porosity1.11.21.8-0.81.4
Bone: cortical porosity0.91.01.6-0.71.3
Bone: cortical thickness1.52.52.8-1.71.5
Bone: cortical thickness0.20.30.4-0.60.4
Bone: cortical tissue density1.62.23.80.8-2.0
Condit. Reinf. active minus inactive responses0.10.10.10.3-0.1
Condit. Reinf. active-inactive response ratio0.70.70.8-0.80.9
Condit. Reinf. active responses1.31.62.41.5-0.9
Condit. Reinf. inactive responses5.66.98.12.9-2.4
Incentive salience index mean0.10.10.10.4-0.0
Condit. Reinf. lever presses0.10.10.20.4-0.2
Condit. Reinf. active minus inactive responses0.30.40.6-0.80.4
Condit. Reinf. active-inactive response ratio0.20.20.2-0.50.4
Condit. Reinf. active responses0.10.20.3-0.60.1
Condit. Reinf. inactive responses0.10.10.20.2-0.5
Condit. Reinf. lever presses0.20.30.4-0.40.6
Condit. Reinf. lever reinforcers received0.00.00.0-0.20.1
Conditioned reinforcement - actives0.50.81.41.2-0.4
Conditioned reinforcement - inactives2.84.16.42.5-1.4
Conditioned locomotion0.40.51.01.00.0
Patch foraging indifference point 0 sec0.30.61.00.2-1.0
Patch foraging indifference point AUC1.21.83.10.7-1.8
Delay disc. indifference point, 0s delay1.31.51.5-1.21.2
Delay disc. indifference point, 16s delay0.80.91.0-1.00.8
Delay disc. indifference point, 2s delay1.51.63.2-1.8-0.2
Delay disc. indifference point, 24s delay0.10.10.2-0.40.1
Delay disc. indifference point, 4s delay1.11.21.9-1.40.6
Delay disc. indifference point, 8s delay1.31.61.7-1.21.3
Indifference point function ln k2.03.45.3-1.22.3
Indifference point function log k2.03.45.3-1.22.3
Patch foraging total patch changes 0 sec0.20.40.70.2-0.8
Patch foraging total patch changes 12 sec2.02.64.01.1-2.0
Patch foraging total patch changes 18 sec1.62.53.71.1-1.9
Patch foraging total patch changes 24 sec0.50.81.60.1-1.3
Patch foraging total patch changes 6 sec1.92.94.41.2-2.1
Patch foraging time to switch 0 sec0.40.91.70.1-1.3
Patch foraging water rate 0 sec1.32.74.5-1.02.1
Patch foraging water rate 12 sec1.32.73.7-1.31.9
Patch foraging water rate 18 sec0.00.10.10.10.3
Patch foraging water rate 24 sec1.21.72.9-0.61.7
Patch foraging water rate 6 sec3.65.26.8-1.92.6
Seeking ratio, delayed vs. immediate footshock0.20.30.4-0.40.7
Distance traveled before self-admin1.41.92.71.6-1.0
Distance traveled after self-admin0.70.81.51.20.3
Extensor digitorum longus weight1.97.614.5-3.80.9
Bone: elastic displacement4.45.07.52.7-1.6
Bone: elastic work0.50.71.31.10.3
Bone: endosteal estimation6.714.715.0-3.93.8
Bone: endosteal perimeter6.213.216.0-4.03.2
Epididymis fat weight1.13.76.8-0.72.6
Delta time in closed arm before/after self-admin0.20.20.3-0.20.5
Delta time in open arm before/after self-admin0.20.20.30.50.2
Diff in mean of infusions in LGA sessions0.10.20.3-0.20.5
Delay discount exponential model param0.50.60.91.0-0.5
Extinction: sum of active levers before priming0.80.80.9-0.90.9
Active lever presses in extinction session 60.40.40.40.70.6
Bone: final force9.214.716.5-3.64.1
Bone: final moment10.516.919.3-3.84.4
Food consumed during 24 hour testing period1.72.34.3-0.62.1
Glucose0.00.10.10.2-0.4
Heart weight1.32.12.9-1.11.7
Delay discount hyperbolic model param0.60.61.11.1-0.4
Intermittent access intake day 1-15 change0.71.41.8-1.01.4
Intermittent access intake escalation1.12.32.4-1.51.5
Intermittent access intake escalation 20.91.11.3-0.91.1
Intermitt. access day 1 inactive lever presses0.20.80.91.0-0.8
Intermitt. access day 15 inactive lever presses0.10.10.2-0.5-0.1
Intermitt. access escalation Index0.81.11.80.7-1.3
Intermittent access day 1 total infusions0.71.11.81.3-0.6
Intermittent access day 15 total infusions0.00.00.0-0.10.2
Intermittent access terminal intake (last 3 days)0.00.00.10.30.1
Intermittent access total infusions0.20.30.50.7-0.2
Intermittent access day 1 locomotion0.81.01.81.4-0.5
Intermittent access day 15 total locomotion0.30.51.00.01.0
Intermittent access total locomotion0.81.01.91.4-0.4
Intermittent access standard deviation0.30.61.2-0.31.1
Left kidney weight2.19.812.0-3.52.8
Right kidney weight3.817.519.4-4.43.9
Cocaine induced anxiety2.43.43.9-1.72.0
Post-drug Anxiety2.83.04.9-1.12.2
Baseline Anxiety0.10.10.10.4-0.1
Tail length1.04.06.6-2.61.2
Length with tail2.611.415.4-3.92.7
Length without tail3.712.012.1-3.53.5
Times rat made contact with spout0.30.30.50.20.7
Lifetime Intake0.70.81.61.3-0.3
Liver weight, left9.916.416.7-4.04.1
Liver weight, right4.67.98.6-2.92.7
Locomotor activity0.60.91.11.0-0.9
Locomotor testing distance1.11.92.21.5-1.3
Locomotor testing rearing0.00.00.1-0.20.1
Locomotion in novel chamber4.86.28.5-2.92.0
Locomotion in novel chamber post-restriction0.20.30.50.20.7
Fecal boli incidents, locomotor time 10.60.91.71.30.2
Change in fecal boli incidents, locomotor task0.60.61.10.4-1.0
Time >=10cm from walls, locomotor time 10.10.10.10.2-0.4
Bouts of movement, locomotor time 11.31.52.61.6-0.7
Total resting periods, locomotor time 13.03.35.22.3-1.2
Rest time, locomotor task time 11.11.41.81.3-1.0
Distance moved, locomotor task time 10.10.10.1-0.4-0.3
Vertical activity count, locomotor time 10.71.83.0-1.70.8
Time >=10cm from walls, locomotor time 20.10.10.1-0.2-0.3
Bouts of movement, locomotor time 21.72.73.4-1.81.4
Total resting periods, locomotor time 21.52.73.5-1.91.3
Rest time, locomotor task time 20.81.01.41.2-0.8
Distance moved, locomotor task time 20.20.20.3-0.6-0.4
Vertical activity count, locomotor time 20.60.91.6-1.30.3
Light reinforcement 11.02.53.11.4-1.8
Light reinforcement 20.00.10.1-0.2-0.3
Bone: marrow area6.414.014.1-3.73.7
Bone: maximum diameter1.73.23.8-1.91.6
Bone: maximum force8.314.714.9-3.83.9
Bone: maximum moment9.817.218.0-4.04.2
Mean time between licks in bursts0.92.33.11.8-1.2
Mean num. licks in bursts2.43.85.1-1.62.3
Cd content in liver0.10.10.1-0.3-0.3
Co content in liver0.40.40.8-0.9-0.2
Cu content in liver2.02.43.2-1.81.3
Fe content in liver0.30.40.7-0.3-0.8
K content in liver0.20.20.3-0.60.0
Mg content in liver0.00.00.10.1-0.2
Mn content in liver0.40.40.50.7-0.5
Na content in liver1.51.62.0-1.41.1
Rb content in liver0.00.00.00.0-0.2
Se content in liver1.21.41.41.2-1.1
Sr content in liver1.51.31.7-1.01.3
Zn content in liver0.10.10.10.2-0.3
Bone: minimum diameter4.98.98.9-3.03.0
Time in familiar zone, hab. session 11.41.32.51.6-0.4
Time in novel zone, hab. session 11.01.01.9-1.4-0.2
Total zone transitions, hab. session 11.82.62.91.5-1.7
Total locomotion distance, hab. session 11.41.92.11.4-1.4
Locomotion velocity, hab. session 11.11.61.91.4-1.1
Time in familiar zone, hab. session 20.80.81.50.31.2
Time in novel zone, hab. session 21.01.02.0-0.2-1.4
Total zone transitions, hab. session 21.31.62.71.6-0.8
Total locomotion distance, hab. session 21.51.92.91.7-1.0
Locomotion velocity, hab. session 21.01.32.21.5-0.7
Novel to familiar place preference ratio1.01.12.2-1.50.3
Novelty place preference0.60.71.3-1.10.1
Time in novel zone, NPP test0.40.40.9-0.9-0.1
Total zone transitions, NPP test4.66.77.82.8-2.4
Total locomotion distance, NPP test5.98.010.03.2-2.5
Locomotion velocity, NPP test4.46.28.32.9-2.0
Intraocular pressure1.42.02.71.6-1.1
Delta distance traveled before/after self-admin1.51.53.0-0.21.7
Delta ambulatory time before/after self-admin1.01.22.4-0.01.6
Parametrial fat weight0.81.93.51.9-0.5
Pavlov. Cond. lever latency0.00.10.10.3-0.1
Pavlov. Cond. magazine entry latency0.81.11.9-1.40.6
Pavlov. Cond. change in total contacts0.60.61.1-1.00.4
Pavlov. Cond. index score0.70.91.7-1.30.4
Pavlov. Cond. latency score0.81.01.8-1.30.4
Pavlov. Cond. lever contacts0.20.20.4-0.60.2
Pavlov. Cond. magazine entry number0.70.91.61.3-0.5
Pavlov. Cond. intertrial magazine entries4.85.88.52.9-1.7
Pavlov. Cond. lever-magazine prob. diff.0.60.71.3-1.10.4
Pavlov. Cond. response bias0.10.20.3-0.50.3
Pavlov. Cond. lever latency0.30.40.6-0.80.5
Pavlov. Cond. magazine entry latency0.80.91.61.3-0.5
Pavlov. Cond. change in total contacts0.10.20.4-0.60.0
Pavlov. Cond. index score0.30.30.50.7-0.4
Pavlov. Cond. latency score0.30.40.50.7-0.5
Pavlov. Cond. lever contacts0.20.20.40.6-0.4
Pavlov. Cond. magazine entry number0.30.30.7-0.80.2
Pavlov. Cond. intertrial magazine entries0.71.11.1-1.11.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.6-0.4
Pavlov. Cond. response bias0.40.50.90.9-0.2
Time in closed arm before self-admin0.40.61.1-1.1-0.0
Time in closed arm after self-admin0.20.20.3-0.5-0.4
Time in open arm before self-admin1.92.12.21.4-1.5
Time in open arm after self-admin0.50.60.91.0-0.4
Bone: periosteal estimation8.918.719.7-4.44.2
Bone: periosteal perimeter7.913.617.2-4.13.2
Bone: post-yield work4.36.47.2-2.42.7
Progressive ratio test 1 active lever presses5.06.19.83.1-1.6
Progressive ratio test 1 breakpoint4.96.09.83.1-1.5
Progressive ratio test 1 inactive lever presses0.60.91.41.2-0.7
Progressive ratio test 2 active lever presses0.10.20.20.5-0.3
Progressive ratio test 2 breakpoint0.10.20.20.4-0.4
Progressive ratio test 2 inactive lever presses0.30.50.90.90.2
Incentive Sensitization - Responses0.91.31.8-1.40.9
Incentive Sensitization - Breakpoint1.01.32.1-1.40.8
Sum of active levers in priming session hrs 5-60.70.71.01.0-0.6
Progressive ratio1.32.02.31.3-1.5
Food seeking constrained by brief footshock1.11.31.41.1-1.2
Seeking ratio, punishment vs. effort0.20.30.4-0.50.6
Retroperitoneal fat weight0.52.14.22.00.2
Reaction time number correct2.75.26.7-1.92.6
Reaction time mean minus median0.82.02.11.4-1.4
Reaction time mean minus median AUC1.02.53.21.8-1.4
Reaction time num false alarms2.23.03.11.7-1.8
Reaction time num false alarms AUC3.04.74.92.1-2.2
Reaction time trials correct on left2.75.26.7-1.92.6
Reaction time trials on left2.64.96.3-1.82.5
Reaction time mean0.00.00.00.0-0.2
Reaction time mean AUC0.00.00.0-0.10.1
Median of all reaction times0.10.20.2-0.50.4
Reaction time omissions3.24.65.02.2-2.1
Reaction time false alarm rate5.77.99.62.5-3.1
Reaction time premature initiation rate1.01.32.11.5-0.8
Reaction time premature initiations0.20.40.60.30.8
Std. dev. reaction times1.63.03.11.7-1.7
Reaction time trials completed2.64.96.3-1.82.5
Reaction time trials AUC3.05.87.1-2.12.7
Run reversals in cocaine runway, females0.90.91.1-1.00.9
Run reversals in cocaine runway, males0.40.40.7-0.3-0.8
Latency to leave start box in cocaine runway1.31.51.61.1-1.3
Latency to leave start box in cocaine runway, F3.54.04.22.0-2.0
Latency to leave start box in cocaine runway, M0.50.50.7-0.80.6
Std. dev. time between licks in bursts1.21.62.01.4-1.1
Total sessions with >9 infusions2.42.94.32.1-1.2
Short access day 1 total inactive lever presses1.72.23.71.9-0.8
Short access day 10 total inactive lever presses0.00.00.0-0.10.2
Short access day 1 total infusions0.40.61.11.10.2
Short access day 10 total infusions0.91.21.71.3-0.9
Short access total infusions1.41.83.41.8-0.5
Short access day 1 locomotion0.40.40.70.8-0.4
Short access day 10 total locomotion0.10.20.50.7-0.1
Short access total locomotion1.41.73.11.8-0.6
One hour access (0.3 mA shock)0.70.81.0-0.71.0
Compulsive drug intake0.00.00.0-0.2-0.2
One hour access (shock baseline)0.60.91.5-0.61.2
Social response proportion0.60.70.9-0.80.9
Social responses1.62.13.11.1-1.8
Social time1.31.82.2-1.21.5
Soleus weight0.92.73.5-1.91.4
Bone: stiffness10.917.820.4-4.53.9
Tibialis anterior weight1.44.79.4-3.1-0.3
Time to tail flick, vehicle, before self-admin0.60.60.80.7-0.9
Time to tail flick, vehicle, after self-admin0.00.10.1-0.3-0.0
Time to tail flick, test, before self-admin0.50.51.10.2-1.0
Time to tail flick, test, after self-admin1.31.42.4-1.50.6
Delta time to tail flick, vehicle, before/after SA0.60.60.8-0.60.9
Delta time to tail flick, test, before/after SA0.70.70.7-0.90.8
Tibia length5.816.117.1-3.94.1
Ambulatory time before self-admin1.72.53.71.9-1.1
Ambulatory time after self-admin0.81.01.81.40.3
Bone: tissue strength0.30.30.4-0.50.6
Total heroin consumption0.60.71.20.41.1
Bone: trabecular number3.96.57.9-2.32.8
Bone: trabecular spacing1.21.62.41.0-1.5
Bone: trabecular thickness0.00.00.00.00.2
Bone: trabecular tissue density1.52.23.11.1-1.8
Water consumed over 24 hours1.01.32.2-0.71.5
Number of responses in last shaping day0.10.20.20.3-0.5