Hub : Genes

LOC134479483

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC134479483	0.03	0.02	5.0e-04	0.04	0	0.03	0	2.1e-04	1.8e-01	1.7e-03	2.7e-01
2	NAcc	gene expression	LOC134479483	0.02	0.01	1.5e-03	0.01	0.01	0.01	0.01	7.1e-03	2.7e-03	2.3e-02	5.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.1	0.2	-0.4	0.1
Area under the delay curve	1.1	1.7	1.7	1.3	-1.3
BMI with tail	2.3	8.0	9.6	3.1	-2.5
BMI without tail	0.9	4.7	5.9	2.4	-1.8
Body weight	1.3	5.9	6.7	-2.3	2.6
Weight adjusted by age	0.1	0.4	0.6	-0.5	0.8
Bone surface	0.3	0.6	0.9	0.5	-1.0
Bone volume	0.2	0.4	0.7	0.4	-0.8
Breakpoint value in progressive ratio session	0.4	0.8	0.8	-0.9	0.8
Number of licking bursts	0.5	1.6	1.8	1.2	-1.3
Context. condit. distance diff. score	3.3	4.0	4.8	-2.2	1.8
Locomotion velocity, session 1	0.3	0.4	0.6	-0.4	0.8
Locomotion distance, session 1	0.0	0.0	0.1	0.2	0.1
Locomotion velocity, session 2	0.2	0.2	0.3	0.6	-0.4
Locomotion distance, session 2	0.3	0.5	0.8	0.9	-0.4
Locomotion velocity, session 3	0.0	0.0	0.0	-0.2	-0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.0
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	-0.3	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.4	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.1
Locomotion distance, session 7	0.7	0.9	0.9	0.9	-1.0
Stereotopy head waving bouts, day 7	2.1	2.4	2.8	-1.7	1.4
Stereotopy head waving duration, day 7	1.3	1.7	2.1	-1.4	1.1
Locomotion velocity, session 8	2.5	3.0	3.4	-1.8	1.6
Locomotion distance, session 8	0.7	1.0	1.0	-1.0	1.0
Degree of sensitization distance	0.3	0.3	0.3	0.5	-0.6
Degree of sensitization stereotypy	0.9	1.0	1.2	-1.1	0.9
Conditioned locomotion	1.9	2.2	2.5	-1.4	1.6
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.3	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.4	-0.2
Cocaine response before conditioning	2.5	3.0	4.2	2.0	-1.4
Saline control response	0.2	0.3	0.4	-0.6	0.4
Bone: connectivity density	0.4	0.6	0.8	-0.9	0.7
Bone: cortical apparent density	3.4	5.4	5.4	-2.3	2.3
Bone: cortical area	0.1	0.2	0.5	-0.7	-0.0
Bone: cortical porosity	0.4	0.4	0.4	-0.7	0.6
Bone: cortical porosity	0.1	0.2	0.2	-0.4	0.4
Bone: cortical thickness	0.9	1.5	2.2	-1.5	1.0
Bone: cortical thickness	0.5	0.6	0.8	-0.9	0.7
Bone: cortical tissue density	3.2	5.1	5.1	-2.2	2.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.1
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.6	1.2	-0.9
Condit. Reinf. active responses	0.2	0.3	0.4	-0.4	0.6
Condit. Reinf. inactive responses	2.5	3.3	3.6	-1.9	1.7
Incentive salience index mean	0.1	0.2	0.3	-0.2	0.5
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.6	0.9
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.3	0.3
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.0
Condit. Reinf. inactive responses	0.3	0.4	0.6	0.8	-0.5
Condit. Reinf. lever presses	2.4	3.6	4.0	2.0	-1.8
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.2	0.1
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.3	0.4
Conditioned reinforcement - inactives	0.3	0.9	1.1	-0.8	1.1
Conditioned locomotion	0.0	0.0	0.1	-0.1	0.2
Patch foraging indifference point 0 sec	4.7	13.3	14.1	-3.5	3.8
Patch foraging indifference point AUC	3.8	9.1	10.0	-2.8	3.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	0.4
Delay disc. indifference point, 16s delay	1.6	2.3	2.5	1.6	-1.4
Delay disc. indifference point, 2s delay	4.6	5.1	5.2	2.2	-2.3
Delay disc. indifference point, 24s delay	0.8	1.3	1.6	1.3	-1.0
Delay disc. indifference point, 4s delay	0.5	0.5	0.6	0.7	-0.7
Delay disc. indifference point, 8s delay	0.3	0.5	0.5	0.7	-0.7
Indifference point function ln k	0.1	0.2	0.4	-0.6	0.2
Indifference point function log k	0.1	0.2	0.4	-0.6	0.2
Patch foraging total patch changes 0 sec	5.3	15.4	16.2	-3.8	4.0
Patch foraging total patch changes 12 sec	4.8	6.4	7.4	-2.3	2.7
Patch foraging total patch changes 18 sec	1.8	4.1	4.6	-1.9	2.2
Patch foraging total patch changes 24 sec	0.7	2.2	2.8	-1.3	1.7
Patch foraging total patch changes 6 sec	7.2	12.1	13.3	-3.3	3.6
Patch foraging time to switch 0 sec	5.1	19.7	20.1	4.4	-4.5
Patch foraging water rate 0 sec	7.8	29.5	30.2	-5.5	5.4
Patch foraging water rate 12 sec	1.9	7.8	8.5	-2.6	2.9
Patch foraging water rate 18 sec	2.0	4.5	5.1	-2.0	2.3
Patch foraging water rate 24 sec	2.8	4.0	4.5	-1.9	2.1
Patch foraging water rate 6 sec	3.7	5.5	5.7	-2.4	2.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.3	-0.6	0.5
Distance traveled before self-admin	0.3	0.7	0.9	1.0	-0.6
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	0.1
Extensor digitorum longus weight	9.2	36.6	38.1	-6.2	5.9
Bone: elastic displacement	0.1	0.1	0.2	0.4	-0.4
Bone: elastic work	0.9	1.1	1.2	1.0	-1.1
Bone: endosteal estimation	1.9	4.7	5.0	2.1	-2.2
Bone: endosteal perimeter	0.3	0.7	1.0	0.7	-1.0
Epididymis fat weight	1.2	6.1	6.8	2.6	-2.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2
Delta time in open arm before/after self-admin	1.0	1.2	1.3	-1.1	1.0
Diff in mean of infusions in LGA sessions	0.7	1.3	1.5	-1.2	1.0
Delay discount exponential model param	1.1	1.4	1.5	-1.2	1.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.5	0.1
Active lever presses in extinction session 6	1.6	1.6	1.6	-1.3	1.2
Bone: final force	0.5	0.8	1.1	0.6	-1.1
Bone: final moment	0.3	0.5	0.9	0.4	-0.9
Food consumed during 24 hour testing period	0.5	1.1	1.1	-1.1	1.0
Glucose	0.0	0.1	0.1	-0.0	-0.4
Heart weight	0.2	0.3	0.4	-0.6	0.4
Delay discount hyperbolic model param	1.3	1.6	1.7	-1.3	1.3
Intermittent access intake day 1-15 change	0.4	2.4	2.5	1.6	-1.5
Intermittent access intake escalation	0.5	2.5	2.6	1.6	-1.6
Intermittent access intake escalation 2	0.6	1.1	1.1	1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.1	1.2	1.3	-1.0	1.2
Intermitt. access day 15 inactive lever presses	0.6	3.5	3.5	-1.9	1.9
Intermitt. access escalation Index	0.1	0.4	0.4	-0.6	0.6
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.2	-0.1
Intermittent access day 15 total infusions	0.5	1.3	1.5	1.2	-1.1
Intermittent access terminal intake (last 3 days)	1.0	1.7	2.0	1.4	-1.2
Intermittent access total infusions	0.3	0.4	0.5	0.7	-0.5
Intermittent access day 1 locomotion	0.1	0.3	0.3	0.6	-0.4
Intermittent access day 15 total locomotion	0.2	0.9	1.1	1.1	-0.8
Intermittent access total locomotion	0.1	0.1	0.1	0.4	-0.2
Intermittent access standard deviation	0.0	0.1	0.1	0.3	-0.0
Left kidney weight	1.4	11.1	11.2	-3.3	3.3
Right kidney weight	1.1	7.8	8.3	-2.7	2.9
Cocaine induced anxiety	0.3	0.8	1.1	-1.1	0.7
Post-drug Anxiety	1.4	1.6	2.0	-1.4	1.1
Baseline Anxiety	0.1	0.1	0.1	0.4	-0.3
Tail length	3.8	20.5	21.6	-4.7	4.4
Length with tail	9.6	42.8	43.6	-6.6	6.5
Length without tail	3.8	20.0	20.1	-4.5	4.5
Times rat made contact with spout	0.4	0.5	0.6	-0.6	0.8
Lifetime Intake	0.4	0.5	0.6	0.8	-0.6
Liver weight, left	3.6	6.3	6.3	-2.5	2.5
Liver weight, right	0.1	0.3	0.5	-0.2	0.7
Locomotor activity	0.1	0.1	0.2	-0.3	0.4
Locomotor testing distance	0.0	0.1	0.1	-0.3	0.3
Locomotor testing rearing	0.8	2.9	3.3	1.8	-1.6
Locomotion in novel chamber	1.1	1.5	1.6	-1.2	1.3
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.2	-0.4
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	0.4	-0.4
Change in fecal boli incidents, locomotor task	0.9	0.9	1.0	-1.0	0.9
Time >=10cm from walls, locomotor time 1	2.8	3.4	3.9	-1.7	2.0
Bouts of movement, locomotor time 1	1.0	1.3	1.4	1.1	-1.2
Total resting periods, locomotor time 1	1.5	1.8	2.0	1.2	-1.4
Rest time, locomotor task time 1	0.5	0.7	0.8	0.8	-0.9
Distance moved, locomotor task time 1	0.3	0.8	0.8	0.9	-0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.2	-0.0
Time >=10cm from walls, locomotor time 2	1.0	2.9	3.0	-1.7	1.7
Bouts of movement, locomotor time 2	0.0	0.2	0.2	0.3	-0.5
Total resting periods, locomotor time 2	0.1	0.3	0.3	0.5	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	-0.2
Distance moved, locomotor task time 2	0.3	0.4	0.4	0.6	-0.6
Vertical activity count, locomotor time 2	0.1	0.2	0.2	-0.5	0.4
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.2
Light reinforcement 2	0.6	1.4	1.7	1.3	-1.0
Bone: marrow area	1.8	4.5	4.8	2.0	-2.2
Bone: maximum diameter	0.2	0.4	0.6	0.3	-0.8
Bone: maximum force	0.1	0.2	0.4	0.3	-0.6
Bone: maximum moment	0.1	0.1	0.2	0.1	-0.5
Mean time between licks in bursts	0.1	0.8	0.8	0.9	-0.9
Mean num. licks in bursts	1.0	2.6	2.8	-1.5	1.7
Cd content in liver	0.1	0.1	0.1	0.2	-0.3
Co content in liver	0.5	0.6	1.0	-1.0	0.5
Cu content in liver	1.5	1.7	1.8	1.3	-1.3
Fe content in liver	0.6	0.7	0.7	0.8	-0.9
K content in liver	0.8	0.8	0.8	-0.9	0.9
Mg content in liver	0.1	0.1	0.1	-0.2	0.3
Mn content in liver	0.0	0.0	0.1	0.1	-0.3
Na content in liver	0.1	0.2	0.2	0.5	-0.3
Rb content in liver	0.3	0.3	0.4	-0.6	0.4
Se content in liver	0.1	0.1	0.1	0.4	-0.0
Sr content in liver	0.0	0.0	0.0	0.2	-0.1
Zn content in liver	0.1	0.1	0.1	-0.3	0.3
Bone: minimum diameter	0.2	0.4	0.7	-0.8	0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.2	-0.2
Time in novel zone, hab. session 1	0.7	0.8	1.0	1.0	-0.7
Total zone transitions, hab. session 1	0.6	0.8	1.0	1.0	-0.8
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	0.1
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.5	0.7
Time in familiar zone, hab. session 2	0.6	0.7	0.7	-0.9	0.8
Time in novel zone, hab. session 2	1.1	1.2	1.2	1.1	-1.1
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.3	0.0
Total locomotion distance, hab. session 2	0.3	0.4	0.5	-0.5	0.7
Locomotion velocity, hab. session 2	0.4	0.6	0.7	-0.7	0.8
Novel to familiar place preference ratio	0.6	0.8	0.8	0.9	-0.8
Novelty place preference	0.8	1.0	1.0	1.0	-1.0
Time in novel zone, NPP test	0.3	0.3	0.3	0.6	-0.5
Total zone transitions, NPP test	0.9	1.4	1.9	-0.9	1.4
Total locomotion distance, NPP test	0.6	0.8	1.2	-0.7	1.1
Locomotion velocity, NPP test	0.3	0.4	0.6	-0.5	0.8
Intraocular pressure	0.3	0.5	0.5	0.7	-0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.4	-0.2
Delta ambulatory time before/after self-admin	0.2	0.4	0.7	-0.8	0.2
Parametrial fat weight	0.0	0.0	0.1	0.0	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.4	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	0.0
Pavlov. Cond. lever contacts	0.2	0.3	0.5	0.7	-0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	9.0	10.9	12.2	-3.5	3.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.3	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.2
Pavlov. Cond. lever latency	3.1	4.3	5.1	-2.2	1.9
Pavlov. Cond. magazine entry latency	2.2	3.1	4.0	2.0	-1.5
Pavlov. Cond. change in total contacts	3.2	7.9	8.4	2.9	-2.7
Pavlov. Cond. index score	3.3	5.2	6.3	2.5	-2.0
Pavlov. Cond. latency score	2.8	4.4	5.5	2.3	-1.8
Pavlov. Cond. lever contacts	3.4	5.0	5.9	2.4	-2.0
Pavlov. Cond. magazine entry number	2.5	3.2	3.7	-1.9	1.7
Pavlov. Cond. intertrial magazine entries	2.4	5.3	5.3	-2.3	2.3
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.9	7.1	2.7	-2.2
Pavlov. Cond. response bias	3.6	4.9	5.9	2.4	-2.0
Time in closed arm before self-admin	5.1	8.8	9.1	3.0	-2.9
Time in closed arm after self-admin	5.4	6.1	6.3	2.5	-2.4
Time in open arm before self-admin	4.9	5.9	6.2	-2.4	2.5
Time in open arm after self-admin	10.2	11.2	11.5	-3.3	3.4
Bone: periosteal estimation	0.5	1.2	1.8	0.9	-1.3
Bone: periosteal perimeter	0.0	0.1	0.1	0.0	-0.4
Bone: post-yield work	1.7	2.9	3.4	-1.8	1.5
Progressive ratio test 1 active lever presses	0.2	0.4	0.5	0.7	-0.6
Progressive ratio test 1 breakpoint	0.3	0.5	0.6	0.7	-0.6
Progressive ratio test 1 inactive lever presses	0.8	2.0	2.2	-1.5	1.4
Progressive ratio test 2 active lever presses	0.4	0.6	0.9	1.0	-0.6
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	0.9	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	-0.0
Incentive Sensitization - Responses	0.1	0.3	0.5	0.7	-0.4
Incentive Sensitization - Breakpoint	0.2	0.4	0.5	0.7	-0.4
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.4	-1.2	0.9
Progressive ratio	0.8	2.3	2.7	1.4	-1.7
Food seeking constrained by brief footshock	0.0	0.1	0.1	-0.3	-0.1
Seeking ratio, punishment vs. effort	0.6	1.3	1.3	-1.2	1.1
Retroperitoneal fat weight	0.1	0.3	0.4	0.6	-0.3
Reaction time number correct	1.5	5.5	6.3	-2.5	2.2
Reaction time mean minus median	0.0	0.0	0.1	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.1	0.2	-0.4
Reaction time num false alarms	1.4	2.3	2.7	-1.4	1.7
Reaction time num false alarms AUC	1.0	2.3	2.6	-1.4	1.6
Reaction time trials correct on left	1.5	5.5	6.3	-2.5	2.2
Reaction time trials on left	1.6	5.5	6.3	-2.5	2.2
Reaction time mean	1.4	3.1	3.2	1.8	-1.8
Reaction time mean AUC	0.8	1.8	2.0	1.3	-1.4
Median of all reaction times	1.9	3.0	3.2	1.7	-1.8
Reaction time omissions	0.1	0.1	0.1	-0.2	0.4
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	0.5
Reaction time premature initiation rate	0.1	0.2	0.2	-0.4	0.5
Reaction time premature initiations	0.9	2.8	3.0	-1.7	1.6
Std. dev. reaction times	0.6	2.0	2.0	1.4	-1.4
Reaction time trials completed	1.6	5.5	6.3	-2.5	2.2
Reaction time trials AUC	1.7	5.8	6.5	-2.6	2.2
Run reversals in cocaine runway, females	1.6	1.8	2.3	1.1	-1.5
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.2	-0.2
Latency to leave start box in cocaine runway	1.2	1.6	1.9	1.4	-1.1
Latency to leave start box in cocaine runway, F	0.6	0.7	0.9	0.9	-0.7
Latency to leave start box in cocaine runway, M	0.8	0.8	1.0	1.0	-0.8
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.4	0.1
Total sessions with >9 infusions	1.2	1.5	1.6	1.3	-1.2
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	0.2
Short access day 10 total inactive lever presses	0.0	0.3	0.4	-0.4	0.6
Short access day 1 total infusions	0.1	0.2	0.2	0.5	-0.4
Short access day 10 total infusions	0.5	0.9	0.9	1.0	-0.9
Short access total infusions	1.2	1.7	1.8	1.4	-1.3
Short access day 1 locomotion	0.8	1.4	1.4	1.2	-1.1
Short access day 10 total locomotion	0.1	0.4	0.5	0.7	-0.6
Short access total locomotion	0.3	0.4	0.6	0.8	-0.5
One hour access (0.3 mA shock)	0.3	0.4	0.6	-0.4	0.8
Compulsive drug intake	1.5	2.3	2.6	-1.4	1.6
One hour access (shock baseline)	0.0	0.1	0.1	0.4	-0.3
Social response proportion	0.6	0.7	0.8	0.9	-0.8
Social responses	0.5	0.7	0.7	0.9	-0.8
Social time	0.1	0.1	0.1	0.4	-0.3
Soleus weight	2.4	7.2	7.5	-2.7	2.6
Bone: stiffness	0.6	1.0	1.3	-1.1	0.9
Tibialis anterior weight	0.9	3.2	3.5	-1.9	1.7
Time to tail flick, vehicle, before self-admin	1.1	1.4	1.8	-1.0	1.3
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	-0.3	0.2
Time to tail flick, test, before self-admin	0.9	1.0	1.0	1.0	-1.0
Time to tail flick, test, after self-admin	2.4	2.6	2.7	-1.6	1.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	0.1
Delta time to tail flick, test, before/after SA	2.4	3.0	3.4	-1.6	1.8
Tibia length	0.1	0.3	0.4	-0.4	0.6
Ambulatory time before self-admin	0.2	0.5	0.7	0.8	-0.5
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	-0.2
Bone: tissue strength	0.3	0.3	0.4	0.5	-0.6
Total heroin consumption	5.4	6.4	6.5	-2.5	2.5
Bone: trabecular number	0.2	0.4	0.5	-0.7	0.6
Bone: trabecular spacing	0.1	0.1	0.2	0.3	-0.4
Bone: trabecular thickness	0.0	0.0	0.0	0.0	0.2
Bone: trabecular tissue density	0.0	0.0	0.0	0.2	-0.2
Water consumed over 24 hours	0.7	1.4	1.7	-1.1	1.3
Number of responses in last shaping day	0.1	0.1	0.2	0.3	-0.4