Hub : Genes

LOC134479481

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC134479481	0.03	0.03	1.3e-03	0.02	0.03	0.02	0.02	3.1e-03	7.7e-04	1.2e-02	2.3e-03
2	NAcc	gene expression	LOC134479481	0.06	0.03	4.9e-15	0.09	0.09	0.08	0.09	9.5e-14	2.2e-13	1.5e-12	7.6e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	0.0	-0.1
Area under the delay curve	0.1	0.2	0.4	-0.6	-0.1
BMI with tail	2.7	9.3	11.4	-3.4	2.7
BMI without tail	0.9	4.6	6.1	-2.5	1.8
Body weight	0.6	2.7	3.0	1.6	-1.7
Weight adjusted by age	0.2	0.6	0.6	0.7	-0.8
Bone surface	0.0	0.0	0.1	-0.2	-0.0
Bone volume	0.0	0.0	0.1	-0.1	-0.2
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.1	0.4
Number of licking bursts	0.0	0.2	0.2	-0.5	0.3
Context. condit. distance diff. score	3.5	4.2	4.6	2.2	-2.0
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.2
Locomotion distance, session 1	0.7	1.0	1.2	-0.8	1.1
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	0.2
Locomotion distance, session 2	0.3	0.4	0.5	-0.7	0.5
Locomotion velocity, session 3	0.1	0.1	0.1	-0.2	0.4
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.2	-0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.2	0.4	-0.5
Locomotion velocity, session 7	0.2	0.2	0.3	-0.4	0.5
Locomotion distance, session 7	0.6	0.8	0.9	-0.9	0.9
Stereotopy head waving bouts, day 7	1.3	1.5	1.6	1.3	-1.2
Stereotopy head waving duration, day 7	0.6	0.8	0.9	0.9	-0.8
Locomotion velocity, session 8	1.1	1.3	1.6	1.3	-1.0
Locomotion distance, session 8	0.2	0.3	0.4	0.6	-0.5
Degree of sensitization distance	0.2	0.2	0.3	-0.5	0.4
Degree of sensitization stereotypy	0.5	0.5	0.6	0.7	-0.7
Conditioned locomotion	1.2	1.4	1.6	1.3	-1.1
Cocaine response after cond. corrected	0.6	0.9	1.0	-0.9	1.0
Cocaine response after cond. not corrected	1.6	2.3	2.4	-1.5	1.5
Cocaine response before conditioning	1.6	1.9	2.4	-1.5	1.2
Saline control response	0.1	0.2	0.2	0.3	-0.5
Bone: connectivity density	0.3	0.5	0.5	0.7	-0.7
Bone: cortical apparent density	5.3	8.4	8.5	2.9	-2.9
Bone: cortical area	0.2	0.3	0.4	0.4	-0.6
Bone: cortical porosity	0.8	0.8	0.8	0.9	-0.9
Bone: cortical porosity	0.1	0.1	0.1	0.3	-0.2
Bone: cortical thickness	0.2	0.4	0.4	0.6	-0.6
Bone: cortical thickness	1.1	1.3	1.5	1.1	-1.2
Bone: cortical tissue density	5.1	8.1	8.3	2.9	-2.8
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	-0.8	0.7
Condit. Reinf. active-inactive response ratio	2.8	3.0	3.0	-1.7	1.7
Condit. Reinf. active responses	0.0	0.1	0.1	-0.3	0.2
Condit. Reinf. inactive responses	1.5	1.9	2.1	1.4	-1.3
Incentive salience index mean	0.4	0.5	0.5	-0.7	0.7
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.9	1.4	1.8	1.0	-1.3
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.3	0.9	-1.1
Condit. Reinf. active responses	0.2	0.2	0.4	0.2	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.8	0.5
Condit. Reinf. lever presses	0.8	1.1	1.5	-1.2	0.8
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	0.4	-0.8
Conditioned reinforcement - actives	0.2	0.7	1.0	0.7	-1.0
Conditioned reinforcement - inactives	0.1	0.4	0.4	0.6	-0.7
Conditioned locomotion	0.0	0.1	0.1	-0.3	0.1
Patch foraging indifference point 0 sec	2.6	7.4	8.1	2.8	-2.6
Patch foraging indifference point AUC	0.7	1.6	2.3	1.5	-0.9
Delay disc. indifference point, 0s delay	0.6	0.7	1.1	0.5	-1.1
Delay disc. indifference point, 16s delay	0.2	0.3	0.5	-0.7	0.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.2	-1.1	0.2
Delay disc. indifference point, 24s delay	0.2	0.3	0.6	-0.8	0.2
Delay disc. indifference point, 4s delay	0.5	0.6	1.0	0.3	-1.0
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	-0.4	-0.1
Indifference point function ln k	0.6	1.8	1.9	1.3	-1.4
Indifference point function log k	0.6	1.8	1.9	1.3	-1.4
Patch foraging total patch changes 0 sec	2.9	8.5	9.4	3.1	-2.8
Patch foraging total patch changes 12 sec	3.2	4.2	4.8	2.2	-1.9
Patch foraging total patch changes 18 sec	0.6	1.4	1.7	1.3	-1.0
Patch foraging total patch changes 24 sec	0.1	0.3	0.5	0.7	-0.4
Patch foraging total patch changes 6 sec	1.7	2.9	3.7	1.9	-1.4
Patch foraging time to switch 0 sec	3.8	14.5	15.8	-4.0	3.6
Patch foraging water rate 0 sec	7.0	26.4	28.6	5.4	-4.9
Patch foraging water rate 12 sec	3.9	15.6	15.9	3.9	-4.0
Patch foraging water rate 18 sec	3.2	7.0	7.1	2.6	-2.7
Patch foraging water rate 24 sec	4.2	5.9	6.2	2.4	-2.5
Patch foraging water rate 6 sec	4.4	6.5	6.9	2.6	-2.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.3	0.6	-0.4
Distance traveled before self-admin	0.2	0.4	0.6	-0.8	0.4
Distance traveled after self-admin	0.4	0.7	1.0	0.6	-1.0
Extensor digitorum longus weight	7.4	29.4	31.8	5.6	-5.2
Bone: elastic displacement	0.4	0.5	0.7	0.6	-0.9
Bone: elastic work	0.1	0.1	0.1	0.1	-0.4
Bone: endosteal estimation	0.1	0.2	0.5	-0.7	0.2
Bone: endosteal perimeter	0.0	0.1	0.2	-0.4	0.2
Epididymis fat weight	1.9	9.5	10.7	-3.3	2.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	-0.4
Delta time in open arm before/after self-admin	0.4	0.4	0.5	0.6	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.0	0.4
Delay discount exponential model param	0.1	0.2	0.3	0.6	0.2
Extinction: sum of active levers before priming	0.4	0.6	0.8	-0.7	0.9
Active lever presses in extinction session 6	1.9	1.9	1.9	1.4	-1.4
Bone: final force	0.1	0.2	0.4	0.2	-0.6
Bone: final moment	0.2	0.3	0.5	0.3	-0.7
Food consumed during 24 hour testing period	0.3	0.6	0.6	0.8	-0.7
Glucose	0.3	0.4	0.5	0.6	-0.7
Heart weight	0.4	0.7	0.8	0.9	-0.8
Delay discount hyperbolic model param	0.1	0.2	0.3	0.6	0.2
Intermittent access intake day 1-15 change	0.6	3.6	3.7	-1.9	1.8
Intermittent access intake escalation	0.7	3.6	3.8	-2.0	1.9
Intermittent access intake escalation 2	1.0	1.7	1.7	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.7	0.9	-0.6
Intermitt. access day 15 inactive lever presses	0.6	3.0	3.2	1.7	-1.8
Intermitt. access escalation Index	0.4	1.4	1.6	1.1	-1.2
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.6	0.3
Intermittent access day 15 total infusions	0.7	1.8	2.2	-1.5	1.2
Intermittent access terminal intake (last 3 days)	1.3	2.2	2.6	-1.6	1.4
Intermittent access total infusions	0.5	0.6	0.8	-0.9	0.6
Intermittent access day 1 locomotion	0.8	1.4	1.6	-1.3	1.1
Intermittent access day 15 total locomotion	0.1	0.6	0.7	-0.8	0.7
Intermittent access total locomotion	0.5	0.6	0.8	-0.9	0.7
Intermittent access standard deviation	0.4	2.3	2.4	-1.5	1.5
Left kidney weight	1.1	9.2	9.6	3.1	-3.0
Right kidney weight	0.9	6.5	7.3	2.7	-2.4
Cocaine induced anxiety	0.5	1.4	1.7	1.3	-1.0
Post-drug Anxiety	2.5	2.8	3.1	1.8	-1.6
Baseline Anxiety	0.0	0.0	0.0	-0.2	0.0
Tail length	3.7	19.6	20.0	4.5	-4.4
Length with tail	7.3	32.5	35.3	5.9	-5.4
Length without tail	2.2	11.4	13.4	3.7	-3.1
Times rat made contact with spout	0.0	0.0	0.1	0.3	-0.1
Lifetime Intake	0.3	0.4	0.6	-0.7	0.4
Liver weight, left	2.5	4.3	4.6	2.2	-2.0
Liver weight, right	0.1	0.2	0.3	-0.3	0.5
Locomotor activity	0.2	0.3	0.3	0.6	-0.5
Locomotor testing distance	0.1	0.3	0.4	0.6	-0.5
Locomotor testing rearing	1.0	3.7	3.8	-1.9	2.0
Locomotion in novel chamber	4.2	5.6	6.5	2.2	-2.6
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	-0.2
Fecal boli incidents, locomotor time 1	0.7	1.8	2.0	-1.4	1.3
Change in fecal boli incidents, locomotor task	2.0	2.1	2.3	1.4	-1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.1	0.5
Bouts of movement, locomotor time 1	1.7	2.2	2.3	-1.4	1.5
Total resting periods, locomotor time 1	1.8	2.1	2.2	-1.4	1.5
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.3	-0.0
Distance moved, locomotor task time 1	0.1	0.3	0.5	-0.4	0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.5	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.6	0.8	-0.2
Bouts of movement, locomotor time 2	0.6	2.1	3.0	1.1	-1.7
Total resting periods, locomotor time 2	0.4	1.7	2.5	0.9	-1.6
Rest time, locomotor task time 2	0.1	0.1	0.2	0.2	-0.5
Distance moved, locomotor task time 2	0.5	0.6	1.0	-0.5	1.0
Vertical activity count, locomotor time 2	0.0	0.1	0.2	0.4	0.1
Light reinforcement 1	0.0	0.0	0.0	0.2	-0.2
Light reinforcement 2	1.3	2.9	3.2	-1.6	1.8
Bone: marrow area	0.1	0.2	0.4	-0.6	0.1
Bone: maximum diameter	0.2	0.3	0.5	-0.7	0.5
Bone: maximum force	0.0	0.1	0.2	0.2	-0.4
Bone: maximum moment	0.1	0.1	0.2	0.2	-0.4
Mean time between licks in bursts	0.1	0.3	0.5	-0.7	0.4
Mean num. licks in bursts	0.1	0.2	0.4	0.6	-0.3
Cd content in liver	0.3	0.3	0.4	0.4	-0.7
Co content in liver	1.2	1.4	1.6	1.3	-1.1
Cu content in liver	1.6	1.9	1.9	-1.3	1.4
Fe content in liver	0.4	0.5	0.5	-0.7	0.7
K content in liver	0.2	0.2	0.4	0.6	-0.3
Mg content in liver	0.2	0.3	0.3	0.5	-0.5
Mn content in liver	0.0	0.0	0.0	0.1	-0.1
Na content in liver	0.8	0.9	0.9	-0.9	1.0
Rb content in liver	0.9	1.1	1.1	1.1	-1.0
Se content in liver	0.1	0.1	0.1	-0.3	0.3
Sr content in liver	0.2	0.2	0.2	0.3	-0.5
Zn content in liver	0.7	0.8	0.8	0.9	-0.9
Bone: minimum diameter	0.7	1.4	1.5	1.1	-1.2
Time in familiar zone, hab. session 1	0.0	0.1	0.1	-0.0	0.3
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.4	0.2
Total locomotion distance, hab. session 1	0.7	1.0	1.4	0.8	-1.2
Locomotion velocity, hab. session 1	1.2	1.7	2.0	1.2	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.1	0.5
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.4	0.0
Total zone transitions, hab. session 2	0.4	0.5	0.6	-0.8	0.7
Total locomotion distance, hab. session 2	0.6	0.7	0.9	0.7	-1.0
Locomotion velocity, hab. session 2	0.7	1.0	1.2	0.9	-1.1
Novel to familiar place preference ratio	0.5	0.6	0.7	-0.8	0.7
Novelty place preference	0.3	0.4	0.5	-0.7	0.5
Time in novel zone, NPP test	0.1	0.2	0.2	-0.5	0.4
Total zone transitions, NPP test	0.2	0.2	0.3	0.5	-0.4
Total locomotion distance, NPP test	0.4	0.6	0.7	0.7	-0.8
Locomotion velocity, NPP test	0.4	0.6	0.7	0.7	-0.8
Intraocular pressure	0.0	0.0	0.0	-0.1	-0.2
Delta distance traveled before/after self-admin	0.1	0.2	0.2	0.3	-0.5
Delta ambulatory time before/after self-admin	0.8	1.4	1.7	1.1	-1.3
Parametrial fat weight	0.1	0.2	0.2	-0.5	0.5
Pavlov. Cond. lever latency	0.6	0.7	0.8	0.9	-0.8
Pavlov. Cond. magazine entry latency	0.3	0.4	0.4	-0.6	0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	0.3
Pavlov. Cond. index score	0.7	0.8	0.9	-1.0	0.9
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.8	0.8
Pavlov. Cond. lever contacts	1.2	1.4	1.6	-1.3	1.1
Pavlov. Cond. magazine entry number	0.4	0.6	0.6	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	6.3	7.6	8.3	2.9	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	0.9	-0.9	0.9
Pavlov. Cond. response bias	0.8	1.0	1.1	-1.0	0.9
Pavlov. Cond. lever latency	1.4	1.9	2.4	1.5	-1.2
Pavlov. Cond. magazine entry latency	2.4	3.4	4.0	-2.0	1.7
Pavlov. Cond. change in total contacts	2.1	5.2	5.9	-2.4	2.1
Pavlov. Cond. index score	2.5	4.0	4.6	-2.1	1.8
Pavlov. Cond. latency score	2.8	4.5	4.8	-2.2	2.0
Pavlov. Cond. lever contacts	1.8	2.6	3.2	-1.8	1.4
Pavlov. Cond. magazine entry number	2.4	3.1	3.5	1.9	-1.6
Pavlov. Cond. intertrial magazine entries	3.1	6.8	6.8	2.6	-2.6
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.8	5.4	-2.3	2.1
Pavlov. Cond. response bias	1.8	2.4	3.2	-1.8	1.3
Time in closed arm before self-admin	3.5	6.1	6.4	-2.4	2.5
Time in closed arm after self-admin	1.4	1.6	2.0	-1.4	1.1
Time in open arm before self-admin	4.1	5.0	5.3	2.3	-2.2
Time in open arm after self-admin	3.6	4.0	4.7	2.2	-1.8
Bone: periosteal estimation	0.0	0.1	0.2	-0.0	-0.4
Bone: periosteal perimeter	0.0	0.0	0.0	-0.2	0.0
Bone: post-yield work	1.7	2.9	3.3	1.8	-1.6
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	-0.5	0.3
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	-0.7	0.4
Progressive ratio test 1 inactive lever presses	1.0	2.7	3.0	1.5	-1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.3	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.2	0.6	0.8	0.6	-0.9
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.0	-0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	-0.1
Progressive ratio	0.0	0.0	0.0	-0.2	-0.0
Food seeking constrained by brief footshock	0.7	0.9	1.2	0.7	-1.1
Seeking ratio, punishment vs. effort	0.1	0.3	0.3	0.5	-0.5
Retroperitoneal fat weight	0.1	0.3	0.4	-0.6	0.5
Reaction time number correct	1.4	5.0	5.5	2.4	-2.1
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.2
Reaction time mean minus median AUC	0.0	0.0	0.0	0.1	-0.0
Reaction time num false alarms	1.0	1.6	1.7	1.3	-1.2
Reaction time num false alarms AUC	1.0	2.3	2.3	1.5	-1.5
Reaction time trials correct on left	1.4	5.0	5.5	2.4	-2.1
Reaction time trials on left	1.5	5.2	5.7	2.4	-2.2
Reaction time mean	0.4	0.9	1.0	-1.0	1.0
Reaction time mean AUC	0.2	0.4	0.5	-0.6	0.7
Median of all reaction times	0.3	0.5	0.5	-0.7	0.7
Reaction time omissions	0.8	1.3	1.3	1.1	-1.1
Reaction time false alarm rate	0.1	0.2	0.3	0.3	-0.5
Reaction time premature initiation rate	0.4	0.6	0.9	0.9	-0.5
Reaction time premature initiations	1.0	3.0	4.0	2.0	-1.4
Std. dev. reaction times	0.1	0.2	0.3	-0.6	0.4
Reaction time trials completed	1.5	5.2	5.7	2.4	-2.2
Reaction time trials AUC	1.6	5.4	6.0	2.4	-2.2
Run reversals in cocaine runway, females	0.5	0.6	0.8	-0.9	0.7
Run reversals in cocaine runway, males	0.0	0.1	0.1	0.3	-0.1
Latency to leave start box in cocaine runway	0.2	0.3	0.6	-0.8	0.2
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	-0.8	0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.4	0.1
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.2	-0.3
Total sessions with >9 infusions	0.2	0.3	0.5	-0.7	0.3
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.1	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.4	-0.4
Short access day 1 total infusions	0.1	0.1	0.2	0.2	-0.5
Short access day 10 total infusions	0.4	0.6	0.9	-0.9	0.6
Short access total infusions	0.2	0.3	0.5	-0.7	0.2
Short access day 1 locomotion	0.2	0.4	0.6	-0.8	0.5
Short access day 10 total locomotion	0.5	2.0	2.1	-1.5	1.4
Short access total locomotion	0.2	0.4	0.5	-0.7	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.1	-0.1
Compulsive drug intake	0.1	0.2	0.3	0.6	-0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	-0.1
Social response proportion	0.0	0.0	0.1	0.2	-0.3
Social responses	0.0	0.0	0.0	-0.2	-0.0
Social time	1.3	2.1	2.4	1.3	-1.5
Soleus weight	0.2	0.6	1.0	1.0	-0.5
Bone: stiffness	0.7	1.2	1.4	1.2	-1.0
Tibialis anterior weight	0.3	1.0	1.2	1.1	-0.9
Time to tail flick, vehicle, before self-admin	0.6	0.7	0.8	0.8	-0.9
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	-0.4	0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	0.2
Time to tail flick, test, after self-admin	0.8	0.8	1.2	1.1	-0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.0	0.4
Delta time to tail flick, test, before/after SA	1.2	1.4	1.7	1.3	-1.1
Tibia length	0.2	0.6	1.0	0.5	-1.0
Ambulatory time before self-admin	0.3	1.0	1.1	-1.1	0.9
Ambulatory time after self-admin	0.0	0.1	0.1	-0.2	-0.3
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.2
Total heroin consumption	1.5	1.7	2.2	1.5	-1.1
Bone: trabecular number	0.2	0.4	0.4	0.6	-0.7
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	0.2
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	0.1
Bone: trabecular tissue density	0.1	0.1	0.1	-0.4	0.3
Water consumed over 24 hours	1.3	2.5	2.6	1.5	-1.6
Number of responses in last shaping day	0.0	0.0	0.0	-0.1	-0.1