Hub : Genes

LOC130046242

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC130046242	0.06	0.04	5.1e-07	0.07	0.06	0.07	0.07	6.9e-08	1.5e-07	2.2e-08	8.6e-08
2	Brain	gene expression	LOC130046242	0.09	0.06	1.7e-07	0.05	0.06	0.06	0.05	4.1e-05	4.0e-06	3.3e-06	9.2e-06
3	Eye	intron excision ratio	chr7_8015439_8015641	0.2	0.14	8.5e-03	0.06	0.03	-0	0.03	4.1e-02	1.1e-01	3.4e-01	1.4e-01
4	NAcc	gene expression	LOC130046242	0.05	0.04	1.7e-06	0.05	0.05	0.04	0.04	2.5e-06	3.5e-06	5.6e-06	5.4e-06
5	Liver	gene expression	LOC130046242	0.06	0.05	1.2e-05	0.03	0.04	0.04	0.03	9.4e-05	5.8e-05	1.5e-05	1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.6	1.1	2.8	-1.7	0.6	0.5	-0.6	-1.3
Area under the delay curve	2.2	2.3	2.7	-1.4	-1.4	1.5	-1.6	-1.7
BMI with tail	6.5	21.2	29.9	-5.5	-4.6	4.6	-4.6	-3.6
BMI without tail	2.0	4.2	6.7	-2.6	-2.3	2.1	-2.0	-1.0
Body weight	1.1	4.7	5.6	-2.2	-2.4	2.2	-2.1	-1.9
Weight adjusted by age	0.2	0.2	0.4	-0.4	-0.6	0.4	-0.3	0.4
Bone surface	0.7	1.2	2.2	-1.4	1.2	0.3	-0.3	-1.5
Bone volume	0.7	1.3	2.5	-1.6	1.2	0.2	-0.3	-1.5
Breakpoint value in progressive ratio session	5.0	5.5	6.7	1.8	2.3	-2.4	2.6	2.5
Number of licking bursts	0.3	0.3	1.4	-1.2	-0.2	0.0	0.0	0.5
Context. condit. distance diff. score	0.3	0.3	0.7	0.1	-0.8	0.7	-0.6	-0.5
Locomotion velocity, session 1	1.6	1.7	7.7	2.8	0.6	-0.6	0.6	0.0
Locomotion distance, session 1	0.7	0.9	3.9	2.0	0.1	0.0	-0.1	-0.7
Locomotion velocity, session 2	3.3	3.8	9.2	3.0	2.0	-1.7	1.6	0.7
Locomotion distance, session 2	2.0	2.8	10.6	3.2	1.2	-1.0	0.9	0.1
Locomotion velocity, session 3	6.5	7.6	9.9	3.1	2.7	-2.8	2.8	2.4
Locomotion distance, session 3	0.1	0.1	0.3	0.5	0.1	-0.2	0.2	0.3
Stereotopy head waving bouts, day 3	4.2	5.0	6.7	2.6	2.4	-2.2	2.2	1.6
Stereotopy head waving duration, day 3	5.3	6.4	9.1	3.0	2.6	-2.5	2.5	1.9
Locomotion velocity, session 7	0.6	0.6	1.2	0.6	1.1	-0.9	0.8	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.0	0.3
Stereotopy head waving bouts, day 7	0.2	0.3	0.6	0.7	-0.1	0.3	-0.2	-0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.8	0.4	-0.0	0.1	-0.6
Locomotion velocity, session 8	0.6	0.7	3.0	1.7	0.6	-0.2	0.3	-0.5
Locomotion distance, session 8	0.4	0.6	3.0	1.7	0.1	-0.2	0.1	-0.1
Degree of sensitization distance	0.5	0.5	0.9	-1.0	-0.6	0.7	-0.7	-0.6
Degree of sensitization stereotypy	2.1	2.3	3.3	-1.1	-1.4	1.6	-1.6	-1.8
Conditioned locomotion	1.2	1.4	2.3	-1.5	-1.5	1.1	-1.1	-0.4
Cocaine response after cond. corrected	3.3	3.7	7.4	-1.1	-2.7	2.0	-2.1	-1.2
Cocaine response after cond. not corrected	3.7	4.0	7.7	-1.3	-2.8	2.1	-2.2	-1.2
Cocaine response before conditioning	0.3	0.4	0.9	-0.2	0.9	-0.6	0.7	0.4
Saline control response	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.2	0.0
Bone: connectivity density	0.7	1.1	2.4	-1.5	0.0	0.8	-0.9	-1.3
Bone: cortical apparent density	1.2	1.5	1.9	-1.2	-1.4	1.3	-1.2	-1.0
Bone: cortical area	1.4	2.1	5.1	-2.3	-0.6	1.2	-1.2	-1.5
Bone: cortical porosity	0.3	0.4	0.9	0.4	0.9	-0.6	0.7	0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.3	0.1	-0.1	-0.5
Bone: cortical thickness	1.7	2.8	5.2	-2.3	-1.2	1.5	-1.6	-1.5
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.0	-0.3	0.2	0.5
Bone: cortical tissue density	0.8	1.1	1.5	-0.9	-1.2	1.1	-1.0	-0.9
Condit. Reinf. active minus inactive responses	4.5	5.1	8.5	2.9	2.1	-2.2	2.1	1.8
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.3	1.8	1.5	-1.7	1.7	1.6
Condit. Reinf. active responses	3.3	4.0	6.7	2.6	2.2	-1.9	1.9	1.2
Condit. Reinf. inactive responses	0.5	0.6	1.2	0.9	1.1	-0.7	0.6	0.1
Incentive salience index mean	2.1	2.5	4.9	2.2	1.7	-1.5	1.4	0.9
Condit. Reinf. lever presses	0.2	0.3	0.9	0.4	0.3	0.2	-0.3	-1.0
Condit. Reinf. active minus inactive responses	2.6	3.3	4.0	1.3	1.8	-1.9	1.9	2.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.3	0.4	0.2	-0.7	0.7	1.2
Condit. Reinf. active responses	2.2	3.0	4.1	1.1	2.0	-1.9	1.8	1.7
Condit. Reinf. inactive responses	0.9	1.1	2.1	0.7	1.4	-1.1	1.0	0.7
Condit. Reinf. lever presses	2.5	3.4	4.0	1.2	1.9	-2.0	2.0	2.0
Condit. Reinf. lever reinforcers received	1.8	2.6	3.3	0.9	1.8	-1.8	1.7	1.7
Conditioned reinforcement - actives	2.5	2.5	3.1	1.4	1.8	-1.6	1.6	1.5
Conditioned reinforcement - inactives	0.4	0.4	1.1	0.3	-1.0	0.6	-0.6	-0.6
Conditioned locomotion	8.0	9.6	10.6	3.0	3.3	-3.2	3.2	2.8
Patch foraging indifference point 0 sec	0.2	0.3	0.6	-0.2	-0.5	0.5	-0.6	-0.8
Patch foraging indifference point AUC	1.1	1.3	1.8	0.9	1.1	-1.1	1.2	1.4
Delay disc. indifference point, 0s delay	7.9	8.6	12.6	-2.2	-2.6	3.1	-3.0	-3.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.6	-0.3	0.3	-0.5	-0.4
Delay disc. indifference point, 2s delay	6.4	7.1	8.1	-2.6	-2.5	2.7	-2.7	-2.8
Delay disc. indifference point, 24s delay	0.5	0.5	1.1	-1.0	-0.6	0.6	-0.8	-0.3
Delay disc. indifference point, 4s delay	1.4	1.5	2.3	-1.1	-0.9	1.2	-1.3	-1.5
Delay disc. indifference point, 8s delay	0.6	0.7	1.2	-0.4	-1.1	0.8	-0.9	-0.7
Indifference point function ln k	0.2	0.3	0.4	-0.2	-0.6	0.5	-0.6	-0.6
Indifference point function log k	0.2	0.3	0.4	-0.2	-0.6	0.5	-0.6	-0.6
Patch foraging total patch changes 0 sec	0.2	0.2	0.5	-0.3	-0.4	0.4	-0.5	-0.7
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	-0.7	-0.6	0.4	-0.5	0.1
Patch foraging total patch changes 18 sec	0.8	1.0	1.3	0.5	1.1	-1.0	1.2	1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.5	0.4	-0.3	0.2	0.4
Patch foraging total patch changes 6 sec	0.3	0.4	1.2	1.1	0.4	-0.5	0.4	0.2
Patch foraging time to switch 0 sec	2.2	3.5	4.6	-2.0	-1.4	1.8	-1.9	-2.2
Patch foraging water rate 0 sec	0.4	0.7	1.5	1.2	0.0	-0.7	0.5	1.1
Patch foraging water rate 12 sec	0.5	0.8	2.0	-0.7	-1.4	0.9	-0.8	-0.1
Patch foraging water rate 18 sec	0.9	1.2	3.3	1.1	0.0	-1.0	0.8	1.8
Patch foraging water rate 24 sec	0.4	0.5	0.9	0.9	-0.9	-0.2	0.1	0.9
Patch foraging water rate 6 sec	0.8	1.2	2.4	1.0	0.6	-1.1	1.1	1.6
Seeking ratio, delayed vs. immediate footshock	3.9	4.5	6.9	1.4	2.6	-2.4	2.3	1.7
Distance traveled before self-admin	0.3	0.3	0.6	-0.7	-0.4	0.4	-0.5	-0.5
Distance traveled after self-admin	1.0	1.1	1.4	1.0	1.2	-1.2	1.0	0.7
Extensor digitorum longus weight	4.2	16.5	27.0	-5.2	-4.2	4.0	-3.9	-2.7
Bone: elastic displacement	0.5	0.5	1.6	1.3	0.5	-0.6	0.6	0.4
Bone: elastic work	0.2	0.3	0.5	-0.3	-0.5	0.6	-0.6	-0.7
Bone: endosteal estimation	0.4	0.8	1.0	-1.0	-0.6	0.9	-0.8	-1.0
Bone: endosteal perimeter	0.1	0.2	0.8	-0.0	0.9	-0.3	0.4	-0.2
Epididymis fat weight	0.2	0.6	1.1	0.4	0.6	-0.8	0.8	1.0
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	-0.9	-0.9	0.2	-0.2	0.8
Delta time in open arm before/after self-admin	1.3	1.3	1.9	-0.6	-1.2	1.2	-1.2	-1.4
Diff in mean of infusions in LGA sessions	1.5	1.7	1.9	1.2	1.3	-1.3	1.4	1.2
Delay discount exponential model param	2.0	2.1	2.3	1.4	1.4	-1.4	1.5	1.5
Extinction: sum of active levers before priming	1.8	1.8	3.0	1.1	1.0	-1.4	1.4	1.7
Active lever presses in extinction session 6	2.9	2.9	3.4	1.6	1.8	-1.7	1.7	1.5
Bone: final force	2.1	3.3	6.8	-2.6	-1.0	1.7	-1.7	-1.8
Bone: final moment	1.7	2.7	5.4	-2.3	-0.9	1.5	-1.5	-1.6
Food consumed during 24 hour testing period	0.4	0.5	0.7	-0.7	-0.8	0.8	-0.8	-0.6
Glucose	0.9	1.4	1.9	-1.0	-1.4	1.2	-1.3	-1.0
Heart weight	0.6	0.9	1.4	0.9	0.6	-1.0	0.9	1.2
Delay discount hyperbolic model param	2.9	3.0	3.3	1.7	1.7	-1.7	1.8	1.8
Intermittent access intake day 1-15 change	7.3	7.3	8.7	2.9	2.6	-2.8	2.8	2.4
Intermittent access intake escalation	7.9	7.8	9.2	3.0	2.4	-2.9	2.9	2.8
Intermittent access intake escalation 2	9.4	9.3	10.0	3.0	2.7	-3.2	3.2	3.2
Intermitt. access day 1 inactive lever presses	0.9	0.9	1.6	1.3	0.6	-0.9	0.9	1.0
Intermitt. access day 15 inactive lever presses	0.8	0.9	2.9	1.7	0.5	-0.7	0.7	0.6
Intermitt. access escalation Index	0.8	0.7	1.5	-1.2	-0.3	0.8	-0.8	-0.8
Intermittent access day 1 total infusions	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.4	-0.4
Intermittent access day 15 total infusions	1.9	2.2	2.8	1.7	1.2	-1.5	1.5	1.5
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.2	0.8	1.1	-1.0	1.0	1.1
Intermittent access total infusions	0.2	0.2	0.4	0.6	0.3	-0.4	0.4	0.4
Intermittent access day 1 locomotion	0.3	0.3	0.8	0.9	0.4	-0.5	0.5	0.4
Intermittent access day 15 total locomotion	3.6	3.9	5.4	2.3	1.8	-2.0	2.0	1.7
Intermittent access total locomotion	0.9	1.0	1.4	1.2	1.0	-1.0	1.0	0.8
Intermittent access standard deviation	3.8	4.0	4.5	2.1	1.8	-2.0	2.0	2.1
Left kidney weight	0.0	0.1	0.3	-0.5	0.5	-0.0	0.1	-0.0
Right kidney weight	1.2	3.4	4.9	1.3	2.2	-1.9	2.0	1.7
Cocaine induced anxiety	0.5	0.5	1.3	0.3	1.2	-0.7	0.7	0.4
Post-drug Anxiety	0.3	0.3	1.0	-0.5	1.0	-0.4	0.4	0.1
Baseline Anxiety	0.1	0.1	0.2	0.1	-0.0	-0.2	0.2	0.5
Tail length	3.5	10.5	12.8	3.6	3.0	-3.2	3.3	3.0
Length with tail	2.0	7.4	13.4	3.7	2.5	-2.6	2.7	1.7
Length without tail	0.1	0.3	0.6	0.8	0.3	-0.1	0.1	-0.8
Times rat made contact with spout	0.1	0.1	0.4	-0.7	-0.4	0.2	-0.3	0.1
Lifetime Intake	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	0.2
Liver weight, left	2.3	3.8	6.9	-2.6	-2.0	1.8	-1.8	-1.2
Liver weight, right	1.7	2.9	3.1	-1.8	-1.7	1.8	-1.7	-1.6
Locomotor activity	2.1	3.4	6.3	1.4	2.5	-1.9	2.0	1.0
Locomotor testing distance	1.4	2.4	3.4	1.6	1.8	-1.6	1.6	1.0
Locomotor testing rearing	0.0	0.1	0.1	0.2	0.0	-0.2	0.3	0.3
Locomotion in novel chamber	0.7	0.8	1.9	0.4	0.8	-0.9	0.8	1.4
Locomotion in novel chamber post-restriction	0.6	0.7	1.0	-0.3	1.0	-0.8	0.9	0.9
Fecal boli incidents, locomotor time 1	1.0	1.1	2.4	-0.5	-1.5	1.0	-1.2	-0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.0	0.7	-0.1	0.4	-0.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.1	-0.0	-0.5	0.7	-0.8	-1.1
Bouts of movement, locomotor time 1	0.4	0.4	1.2	1.1	0.4	-0.5	0.4	0.6
Total resting periods, locomotor time 1	0.4	0.4	1.1	1.1	0.5	-0.6	0.4	0.5
Rest time, locomotor task time 1	0.2	0.2	0.6	0.7	0.4	-0.3	0.4	0.2
Distance moved, locomotor task time 1	0.7	0.8	1.9	-0.8	-0.4	0.9	-0.8	-1.4
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.4	-1.5	-1.2	1.1	-1.0	-0.7
Bouts of movement, locomotor time 2	0.5	0.5	1.7	1.3	0.7	-0.4	0.4	-0.1
Total resting periods, locomotor time 2	0.4	0.4	1.5	1.2	0.7	-0.4	0.3	-0.1
Rest time, locomotor task time 2	0.3	0.4	0.7	0.8	0.8	-0.6	0.4	0.4
Distance moved, locomotor task time 2	0.6	0.7	1.2	-0.8	-1.1	0.9	-0.8	-0.6
Vertical activity count, locomotor time 2	0.4	0.5	1.2	-0.6	-1.1	0.7	-0.5	-0.2
Light reinforcement 1	5.2	9.5	11.5	3.4	3.2	-3.1	3.1	2.5
Light reinforcement 2	1.5	2.0	2.4	1.5	1.6	-1.4	1.5	0.9
Bone: marrow area	0.4	0.8	1.1	-1.0	-0.6	1.0	-0.8	-1.0
Bone: maximum diameter	0.3	0.5	1.8	-0.3	1.3	-0.6	0.7	-0.0
Bone: maximum force	2.1	3.6	7.1	-2.7	-1.2	1.8	-1.7	-1.8
Bone: maximum moment	1.7	3.0	5.5	-2.4	-1.1	1.6	-1.6	-1.7
Mean time between licks in bursts	4.3	6.0	6.8	2.6	2.2	-2.5	2.5	2.4
Mean num. licks in bursts	0.2	0.2	1.1	1.0	-0.1	0.1	-0.2	-0.3
Cd content in liver	0.5	0.6	2.0	-1.4	-0.3	0.5	-0.5	-0.5
Co content in liver	0.6	0.7	1.0	-0.2	1.0	-0.9	0.9	0.9
Cu content in liver	0.3	0.3	0.8	-0.5	-0.1	0.5	-0.5	-0.9
Fe content in liver	0.1	0.1	0.2	0.2	0.0	-0.2	0.2	0.5
K content in liver	0.1	0.1	0.3	0.5	0.0	0.2	-0.2	-0.6
Mg content in liver	0.1	0.1	0.4	0.0	0.2	0.2	-0.2	-0.6
Mn content in liver	0.7	0.8	2.2	1.5	1.1	-0.5	0.5	-0.4
Na content in liver	1.2	1.3	1.9	-0.8	-1.0	1.2	-1.2	-1.4
Rb content in liver	0.7	0.9	1.5	-1.1	-0.5	0.9	-0.9	-1.2
Se content in liver	0.2	0.3	0.8	0.9	0.4	-0.4	0.4	0.3
Sr content in liver	0.2	0.1	0.5	-0.0	-0.1	-0.3	0.3	0.7
Zn content in liver	3.0	3.4	5.3	1.6	1.4	-1.9	1.9	2.3
Bone: minimum diameter	0.1	0.3	0.5	-0.7	0.1	0.4	-0.3	-0.7
Time in familiar zone, hab. session 1	2.6	2.4	3.0	1.7	1.4	-1.6	1.5	1.5
Time in novel zone, hab. session 1	1.9	1.8	3.2	-1.8	-0.7	1.2	-1.2	-1.5
Total zone transitions, hab. session 1	0.9	1.2	3.6	1.9	1.1	-0.8	0.7	0.1
Total locomotion distance, hab. session 1	0.9	1.2	3.3	1.8	1.3	-0.8	0.6	-0.3
Locomotion velocity, hab. session 1	1.3	1.8	4.6	2.2	1.5	-1.1	1.0	0.2
Time in familiar zone, hab. session 2	7.1	7.3	8.0	2.5	2.6	-2.8	2.8	2.8
Time in novel zone, hab. session 2	5.4	5.4	6.4	-2.1	-2.1	2.4	-2.4	-2.5
Total zone transitions, hab. session 2	1.0	1.3	2.9	1.7	-0.7	0.7	-0.9	-1.3
Total locomotion distance, hab. session 2	1.7	2.2	9.0	3.0	0.8	-0.9	0.7	0.2
Locomotion velocity, hab. session 2	1.5	2.0	8.5	2.9	0.8	-0.7	0.6	-0.0
Novel to familiar place preference ratio	4.4	4.6	6.4	-1.5	-2.0	2.3	-2.2	-2.5
Novelty place preference	2.7	2.7	4.2	-0.9	-1.5	1.8	-1.7	-2.1
Time in novel zone, NPP test	3.0	3.1	4.4	-1.2	-1.6	1.9	-1.8	-2.1
Total zone transitions, NPP test	0.5	0.7	3.0	1.7	-0.3	0.2	-0.4	-0.6
Total locomotion distance, NPP test	0.4	0.5	1.6	1.3	-0.2	0.3	-0.5	-0.8
Locomotion velocity, NPP test	0.5	0.7	3.1	1.7	0.0	0.0	-0.2	-0.5
Intraocular pressure	0.4	0.5	1.9	0.2	0.1	-0.6	0.5	1.4
Delta distance traveled before/after self-admin	1.5	1.6	2.0	1.4	1.4	-1.3	1.3	1.0
Delta ambulatory time before/after self-admin	1.4	1.6	2.2	1.2	1.5	-1.3	1.2	1.0
Parametrial fat weight	0.5	0.9	1.1	0.9	1.0	-1.0	1.1	0.8
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.0	-0.0	-0.3	0.3	0.8
Pavlov. Cond. magazine entry latency	3.1	3.9	6.3	2.5	1.7	-1.9	1.9	1.7
Pavlov. Cond. change in total contacts	0.3	0.3	1.2	1.1	0.1	-0.3	0.2	0.2
Pavlov. Cond. index score	0.4	0.5	1.5	1.2	0.6	-0.5	0.5	0.1
Pavlov. Cond. latency score	0.3	0.4	1.3	1.1	0.6	-0.4	0.4	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.5	0.3	0.4	0.1	-0.1	-0.7
Pavlov. Cond. magazine entry number	0.7	0.9	2.0	-1.4	-0.8	0.8	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.1	0.3	-0.5	0.4	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.3	1.5	0.9	-0.8	0.8	0.4
Pavlov. Cond. response bias	1.1	1.4	2.5	1.6	1.1	-1.1	1.1	0.9
Pavlov. Cond. lever latency	0.7	1.0	1.6	-0.2	-1.3	1.1	-1.1	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.3	0.9	-0.6	0.8	0.4
Pavlov. Cond. change in total contacts	0.9	1.2	1.7	0.6	1.3	-1.2	1.2	1.1
Pavlov. Cond. index score	0.8	1.0	1.7	0.1	1.3	-1.1	1.2	0.9
Pavlov. Cond. latency score	0.7	0.8	1.6	-0.1	1.3	-1.0	1.1	0.7
Pavlov. Cond. lever contacts	0.8	1.1	1.4	0.5	1.1	-1.1	1.2	1.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.4	-0.1	-1.2	0.9	-1.0	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	0.2	-1.1	0.6	-0.7	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.7	0.1	1.3	-1.1	1.2	0.8
Pavlov. Cond. response bias	1.8	2.5	3.2	0.9	1.7	-1.7	1.8	1.6
Time in closed arm before self-admin	1.4	1.6	3.0	-0.9	-0.9	1.3	-1.3	-1.7
Time in closed arm after self-admin	0.1	0.1	0.2	-0.5	0.2	-0.3	0.2	0.4
Time in open arm before self-admin	1.4	1.5	1.7	1.3	1.1	-1.2	1.2	1.2
Time in open arm after self-admin	0.6	0.7	1.0	-0.1	-1.0	0.9	-0.8	-0.9
Bone: periosteal estimation	0.9	1.9	3.9	-2.0	-0.6	1.3	-1.2	-1.6
Bone: periosteal perimeter	0.2	0.4	1.0	-1.0	0.5	0.2	-0.1	-0.7
Bone: post-yield work	0.9	1.2	2.5	-1.6	-0.9	1.1	-1.0	-0.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.3	-0.5	0.3	-0.3	-0.1
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.6	-0.6	0.5	-0.5	-0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.2	0.0	-0.0	0.0	-0.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.6	0.7	0.4	-0.6	0.6	0.8
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.5	0.6	-0.6	0.6	0.7
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	0.2	-0.1	0.1	0.1
Incentive Sensitization - Responses	0.6	0.6	1.0	0.6	0.6	-0.7	0.7	1.0
Incentive Sensitization - Breakpoint	0.6	0.6	1.1	0.5	0.7	-0.8	0.8	1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.4	-0.1	-0.0	0.0	0.2
Progressive ratio	0.1	0.1	0.2	0.2	-0.4	0.3	-0.2	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.4	-0.3	0.2	0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.5	0.3	-0.2	0.1	-0.2
Retroperitoneal fat weight	0.4	1.2	2.4	-0.0	-1.5	1.1	-1.1	-1.0
Reaction time number correct	0.3	0.4	1.0	-0.4	-1.0	0.6	-0.6	0.1
Reaction time mean minus median	0.8	1.0	1.2	0.9	1.1	-1.1	1.0	1.0
Reaction time mean minus median AUC	0.1	0.1	0.2	0.3	0.2	0.2	-0.2	-0.5
Reaction time num false alarms	0.0	0.0	0.1	0.0	-0.3	0.1	-0.1	0.2
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.1	-0.5	0.2	-0.1	0.4
Reaction time trials correct on left	0.3	0.4	1.0	-0.4	-1.0	0.6	-0.6	0.1
Reaction time trials on left	0.3	0.4	1.0	-0.5	-1.0	0.6	-0.6	0.0
Reaction time mean	0.1	0.1	0.3	-0.5	0.1	0.2	-0.3	-0.5
Reaction time mean AUC	0.2	0.2	0.4	-0.6	-0.0	0.4	-0.4	-0.6
Median of all reaction times	0.6	0.8	1.1	-1.0	-0.5	0.8	-0.8	-1.1
Reaction time omissions	0.2	0.2	0.3	0.6	0.5	-0.4	0.5	0.3
Reaction time false alarm rate	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.0
Reaction time premature initiation rate	1.6	2.2	5.2	2.3	0.9	-1.3	1.3	1.2
Reaction time premature initiations	1.3	1.8	4.7	2.2	0.4	-1.1	1.1	1.4
Std. dev. reaction times	0.2	0.3	0.7	0.8	0.6	-0.5	0.4	0.4
Reaction time trials completed	0.3	0.4	1.0	-0.5	-1.0	0.6	-0.6	0.0
Reaction time trials AUC	0.2	0.3	1.0	-0.3	-1.0	0.5	-0.5	0.2
Run reversals in cocaine runway, females	0.6	0.6	1.2	0.7	1.1	-0.8	0.6	0.5
Run reversals in cocaine runway, males	0.8	0.8	1.7	-0.4	1.3	-1.0	0.9	0.8
Latency to leave start box in cocaine runway	0.5	0.6	1.3	0.8	1.1	-0.7	0.6	0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-0.6	0.2	0.5	-0.5	-1.0
Latency to leave start box in cocaine runway, M	4.2	4.1	5.5	2.3	1.6	-1.9	2.0	2.2
Std. dev. time between licks in bursts	0.5	0.5	1.3	0.6	1.1	-0.7	0.7	0.2
Total sessions with >9 infusions	0.2	0.2	0.8	-0.9	0.2	0.2	-0.2	-0.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	0.3
Short access day 10 total inactive lever presses	0.2	0.2	0.7	0.8	0.1	-0.4	0.4	0.5
Short access day 1 total infusions	0.2	0.2	1.1	-1.0	0.4	0.0	-0.0	-0.1
Short access day 10 total infusions	0.1	0.1	0.3	-0.5	-0.0	0.1	-0.1	0.3
Short access total infusions	0.3	0.3	1.3	-1.1	0.0	0.2	-0.2	0.1
Short access day 1 locomotion	0.5	0.5	0.9	1.0	0.9	-0.7	0.7	0.1
Short access day 10 total locomotion	4.7	5.3	7.4	2.7	2.1	-2.3	2.3	2.0
Short access total locomotion	0.6	0.6	0.9	0.6	0.9	-0.8	0.8	0.6
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.0	-0.6	0.5	-0.5	-0.5
Compulsive drug intake	0.9	0.9	1.2	-0.9	-0.9	0.9	-0.9	-1.1
One hour access (shock baseline)	0.1	0.2	0.7	0.8	-0.0	-0.2	0.2	0.3
Social response proportion	0.6	0.7	1.4	1.2	0.8	-0.7	0.7	0.5
Social responses	6.4	8.3	10.2	3.1	3.2	-2.8	3.0	2.2
Social time	0.6	0.8	1.6	0.0	-1.2	1.0	-0.9	-0.8
Soleus weight	9.6	28.1	43.9	-6.6	-5.1	5.2	-5.1	-4.2
Bone: stiffness	4.7	7.4	16.4	-4.0	-1.8	2.5	-2.4	-2.3
Tibialis anterior weight	1.4	4.9	13.6	-3.7	-1.5	1.8	-1.8	-1.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	-0.4	1.0	-0.5	0.5	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.4	1.1	0.5	0.2	-0.6	0.5	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	0.5	0.0	0.0	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.2	0.5	-0.1	0.2	0.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.0	-0.9	0.3	-0.3	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.5	0.2	-0.5	0.4	0.6
Tibia length	1.0	2.8	3.1	1.7	1.7	-1.7	1.8	1.4
Ambulatory time before self-admin	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.5	-0.5
Ambulatory time after self-admin	0.5	0.6	0.8	0.6	0.9	-0.9	0.8	0.6
Bone: tissue strength	2.1	2.0	2.6	-1.0	-1.6	1.6	-1.5	-1.4
Total heroin consumption	1.6	1.8	2.5	0.8	1.6	-1.4	1.4	1.4
Bone: trabecular number	0.4	0.7	2.3	-0.1	1.5	-0.8	0.7	0.0
Bone: trabecular spacing	0.4	0.5	1.3	0.8	-1.1	0.1	-0.1	0.7
Bone: trabecular thickness	1.1	1.3	2.7	-1.5	0.7	0.6	-0.7	-1.6
Bone: trabecular tissue density	2.1	3.0	4.3	-2.0	-2.1	1.8	-1.6	-1.0
Water consumed over 24 hours	1.2	1.4	3.3	-1.8	-0.4	1.0	-1.0	-1.3
Number of responses in last shaping day	0.1	0.1	0.1	0.2	0.4	-0.3	0.3	0.3