LOC120103483

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr6_21677426_21690911	0.1	0.06	2.7e-03	0.01	0.02	0.03	0.02	8.2e-03	6.6e-03	3.4e-04	3.0e-03
2	Liver	intron excision ratio	chr6_21691204_21696224	0.07	0.04	3.6e-05	0.04	0.04	0.04	0.04	1.0e-05	2.1e-05	3.3e-05	4.4e-05
3	Liver	intron excision ratio	chr6_21677426_21698723	0.27	0.1	1.7e-16	0.15	0.12	0.1	0.13	6.6e-16	7.0e-13	1.5e-11	1.1e-14
4	Liver	intron excision ratio	chr6_21696306_21698723	0.11	0.05	1.3e-09	0.05	0.07	0.07	0.07	1.1e-06	7.0e-08	5.6e-08	6.4e-08
5	Liver	gene expression	LOC120103483	0.32	0.09	0.0e+00	0.28	0.3	0.31	0.31	4.2e-31	1.1e-33	5.3e-35	1.6e-34
6	Liver	isoform ratio	XR_005505720.1	0.06	0.03	1.4e-06	0.07	0.06	0.06	0.06	6.4e-08	1.9e-07	6.4e-07	2.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.7	4.5	8.6	-1.0	-2.4	2.2	-2.9	-2.4	0.8
Area under the delay curve	2.0	2.2	6.8	-2.6	-1.6	1.6	-0.6	-0.3	-0.8
BMI with tail	0.5	1.5	4.2	2.1	1.3	-1.1	0.4	1.2	-0.7
BMI without tail	0.6	1.3	1.9	1.4	1.2	-1.1	1.1	1.1	-0.8
Body weight	1.5	6.4	10.2	2.1	2.9	-2.7	2.7	3.2	-1.2
Weight adjusted by age	0.9	1.0	1.6	-1.1	-1.2	1.2	-1.1	-0.9	-0.1
Bone surface	1.4	2.5	4.6	-0.6	-1.8	1.5	-2.2	-2.0	1.0
Bone volume	1.4	2.4	4.4	-0.6	-1.7	1.4	-2.1	-1.8	1.1
Breakpoint value in progressive ratio session	0.3	0.3	0.5	0.5	0.6	-0.7	-0.1	-0.5	0.6
Number of licking bursts	0.5	0.6	1.2	-0.2	0.7	-0.7	0.5	0.9	-1.1
Context. condit. distance diff. score	0.3	0.3	0.9	-0.1	0.6	-0.7	0.5	0.9	-0.1
Locomotion velocity, session 1	1.0	1.0	2.5	0.9	-0.7	0.7	-1.0	-1.6	1.0
Locomotion distance, session 1	0.7	0.9	1.3	-0.5	-1.1	1.2	-0.9	-1.1	-0.6
Locomotion velocity, session 2	0.2	0.2	0.3	-0.6	-0.5	0.4	-0.2	-0.3	-0.4
Locomotion distance, session 2	0.1	0.2	0.6	0.8	-0.1	0.2	-0.5	-0.4	-0.4
Locomotion velocity, session 3	2.1	2.4	4.1	-1.5	-1.7	1.6	-1.7	-2.0	-0.0
Locomotion distance, session 3	0.0	0.1	0.1	-0.4	-0.2	0.2	0.0	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.6	0.7	1.6	-1.3	-0.7	0.8	-0.1	-0.9	0.8
Stereotopy head waving duration, day 3	0.5	0.6	1.4	-1.2	-0.7	0.7	-0.3	-0.8	0.6
Locomotion velocity, session 7	0.6	0.6	1.2	-0.4	-0.7	0.6	-1.1	-0.7	-1.0
Locomotion distance, session 7	0.2	0.3	0.8	0.5	0.0	0.0	-0.2	0.7	-0.9
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	-0.5	-0.6	0.5	-0.8	-0.8	0.5
Stereotopy head waving duration, day 7	1.5	1.8	2.7	-1.4	-1.6	1.5	-1.2	-1.6	0.6
Locomotion velocity, session 8	0.6	0.7	1.5	0.7	-0.9	0.7	-0.8	-1.2	0.3
Locomotion distance, session 8	0.2	0.2	0.7	0.1	0.2	-0.3	0.1	0.7	-0.9
Degree of sensitization distance	0.4	0.4	1.2	0.8	0.3	-0.3	-0.1	1.1	-0.6
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.7	-0.5	0.3	-0.4	0.0	-0.5
Conditioned locomotion	1.3	1.5	2.3	-1.5	-1.4	1.3	-1.4	-0.5	-1.0
Cocaine response after cond. corrected	1.2	1.4	2.1	-0.5	-1.4	1.4	-1.5	-1.4	0.3
Cocaine response after cond. not corrected	1.6	1.7	2.9	-0.7	-1.5	1.5	-1.4	-1.7	0.5
Cocaine response before conditioning	0.2	0.2	0.7	-0.8	0.1	-0.1	0.6	-0.4	0.4
Saline control response	0.7	0.9	1.5	-0.6	1.2	-1.2	1.0	-0.2	0.8
Bone: connectivity density	3.2	5.1	9.2	-1.2	-2.7	2.4	-3.0	-2.5	0.5
Bone: cortical apparent density	0.5	0.6	2.3	0.7	0.4	-0.1	-0.1	-1.0	1.5
Bone: cortical area	0.0	0.0	0.2	-0.1	0.0	-0.2	-0.5	-0.1	0.1
Bone: cortical porosity	4.4	4.8	8.7	-2.0	-2.9	2.8	-2.5	-1.1	-0.8
Bone: cortical porosity	4.0	4.3	8.0	-1.6	-2.8	2.7	-2.5	-1.0	-0.8
Bone: cortical thickness	0.1	0.2	0.4	0.6	0.3	-0.3	-0.5	0.3	0.1
Bone: cortical thickness	0.9	1.0	2.0	-0.6	-1.3	1.3	-1.4	-0.4	-0.5
Bone: cortical tissue density	0.5	0.7	2.5	0.8	0.5	-0.2	-0.0	-1.0	1.6
Condit. Reinf. active minus inactive responses	0.6	0.7	3.4	1.8	0.4	-0.5	0.2	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.9	1.4	0.1	-0.1	-0.5	-0.8	0.9
Condit. Reinf. active responses	0.5	0.6	2.3	1.0	-0.1	0.2	0.0	0.6	-1.5
Condit. Reinf. inactive responses	0.7	0.8	3.5	-0.3	-0.7	0.7	-0.2	0.6	-1.9
Incentive salience index mean	0.2	0.3	1.1	0.4	-0.4	0.5	-0.3	-0.1	-1.0
Condit. Reinf. lever presses	1.3	1.7	3.1	-1.6	-1.3	1.4	-0.9	-0.5	-1.8
Condit. Reinf. active minus inactive responses	0.5	0.7	2.1	-0.3	0.0	-0.3	0.7	1.1	-1.4
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.5	-1.0	-0.4	0.3	0.3	0.7	-1.6
Condit. Reinf. active responses	0.2	0.3	0.6	-0.0	0.2	-0.4	0.8	0.7	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.1	-0.2	0.3	0.1	-0.1
Condit. Reinf. lever presses	0.2	0.2	0.4	0.2	0.3	-0.4	0.5	0.6	-0.6
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	0.2	0.1	-0.4	0.6	0.6	-0.8
Conditioned reinforcement - actives	0.7	0.7	1.2	0.5	0.9	-0.9	-0.6	-0.9	1.1
Conditioned reinforcement - inactives	1.2	1.4	2.8	0.7	1.1	-1.0	0.5	-1.5	1.7
Conditioned locomotion	1.3	1.6	2.9	0.6	1.6	-1.4	1.2	-0.5	1.7
Patch foraging indifference point 0 sec	0.2	0.3	0.6	-0.4	-0.5	0.8	-0.2	-0.5	0.5
Patch foraging indifference point AUC	0.1	0.1	0.5	0.0	0.0	0.1	-0.3	-0.7	0.2
Delay disc. indifference point, 0s delay	0.4	0.5	1.1	-1.1	-0.3	0.6	0.2	0.6	-0.8
Delay disc. indifference point, 16s delay	2.4	2.4	4.0	-2.0	-2.0	2.0	-1.3	-0.9	-0.4
Delay disc. indifference point, 2s delay	1.5	1.7	3.3	-1.8	-1.5	1.7	-1.1	-0.7	-0.4
Delay disc. indifference point, 24s delay	4.2	4.0	9.8	-3.1	-2.4	2.2	-1.5	-1.1	-0.7
Delay disc. indifference point, 4s delay	3.2	3.3	6.3	-1.9	-2.5	2.5	-1.3	-1.5	0.3
Delay disc. indifference point, 8s delay	1.5	1.5	5.5	-2.3	-1.0	1.1	-0.3	0.1	-1.1
Indifference point function ln k	0.5	0.7	1.4	-0.5	-0.9	1.0	-1.2	-0.7	0.3
Indifference point function log k	0.5	0.7	1.4	-0.5	-0.9	1.0	-1.2	-0.7	0.3
Patch foraging total patch changes 0 sec	0.1	0.1	0.5	-0.4	-0.4	0.7	-0.0	-0.2	0.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.2	0.0	0.1	-0.0	0.3	-0.3
Patch foraging total patch changes 18 sec	0.2	0.3	1.0	0.3	0.5	-0.4	1.0	0.0	0.5
Patch foraging total patch changes 24 sec	0.3	0.3	1.2	0.1	0.4	-0.4	1.1	0.7	0.2
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	-0.4	0.5	-0.3	0.1	-0.5
Patch foraging time to switch 0 sec	0.2	0.3	0.7	-0.3	-0.3	0.0	0.3	0.7	-0.8
Patch foraging water rate 0 sec	0.5	0.7	1.1	-0.9	-0.7	1.0	-1.0	-0.9	0.3
Patch foraging water rate 12 sec	0.1	0.2	0.5	-0.5	-0.7	0.7	0.2	0.1	-0.0
Patch foraging water rate 18 sec	0.4	0.6	2.1	-1.5	0.3	-0.2	0.7	0.6	-0.7
Patch foraging water rate 24 sec	1.0	1.3	3.4	0.0	0.9	-0.9	1.4	1.8	-1.0
Patch foraging water rate 6 sec	0.2	0.2	0.8	-0.9	-0.4	0.6	0.1	0.0	-0.3
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	3.3	0.2	1.1	-1.0	1.4	-0.5	1.8
Distance traveled before self-admin	1.6	1.7	3.2	0.5	1.3	-1.5	1.8	1.3	-1.0
Distance traveled after self-admin	0.9	1.0	1.4	0.4	0.9	-1.0	1.1	1.2	-1.1
Extensor digitorum longus weight	0.0	0.2	0.7	-0.8	-0.0	0.1	0.1	-0.3	-0.4
Bone: elastic displacement	0.6	0.7	1.3	-0.7	-0.9	0.8	-1.2	-0.3	-0.9
Bone: elastic work	1.1	1.4	3.2	-0.9	-1.4	1.1	-1.8	-0.7	-1.0
Bone: endosteal estimation	0.1	0.2	0.4	-0.4	-0.5	0.3	-0.3	-0.6	0.1
Bone: endosteal perimeter	0.2	0.4	0.7	-0.8	0.7	-0.9	0.8	0.3	0.2
Epididymis fat weight	1.9	4.4	9.5	3.1	2.3	-2.3	1.3	2.1	0.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	-0.1	-0.9	0.8	-0.8	0.2	-0.6
Delta time in open arm before/after self-admin	0.6	0.6	2.0	0.3	0.1	-0.3	0.7	-0.9	1.4
Diff in mean of infusions in LGA sessions	1.5	1.7	3.5	1.6	0.2	-0.3	-1.0	-1.7	1.9
Delay discount exponential model param	2.6	2.8	7.6	2.8	1.9	-1.9	0.9	0.5	0.8
Extinction: sum of active levers before priming	0.4	0.4	1.7	-0.4	-0.4	0.2	-0.1	0.5	-1.3
Active lever presses in extinction session 6	1.6	1.5	3.7	-0.0	-0.5	0.2	-1.3	-1.9	1.9
Bone: final force	1.7	2.8	6.1	-0.2	-1.7	1.7	-2.5	-2.0	1.0
Bone: final moment	1.8	2.9	6.0	-0.1	-1.8	1.8	-2.5	-2.0	0.9
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.7	0.2	-0.1	0.5	0.7	-0.4
Glucose	1.0	1.5	2.2	1.1	1.4	-1.5	1.4	0.6	0.9
Heart weight	1.8	2.5	4.7	2.2	1.6	-1.4	1.7	1.4	0.9
Delay discount hyperbolic model param	2.4	2.5	6.7	2.6	1.9	-1.9	0.8	0.6	0.7
Intermittent access intake day 1-15 change	0.3	0.3	0.7	-0.5	-0.9	0.8	-0.0	0.1	-0.3
Intermittent access intake escalation	0.6	0.6	1.6	-0.4	-1.3	1.2	-0.2	-0.0	-0.4
Intermittent access intake escalation 2	0.2	0.2	0.8	0.9	-0.3	0.1	0.1	0.3	0.2
Intermitt. access day 1 inactive lever presses	1.5	1.6	3.3	0.4	1.5	-1.5	1.8	1.3	0.2
Intermitt. access day 15 inactive lever presses	1.4	1.5	5.6	1.2	0.7	-0.5	0.0	-1.1	2.4
Intermitt. access escalation Index	0.4	0.3	0.7	0.3	0.8	-0.4	-0.1	0.6	-0.8
Intermittent access day 1 total infusions	0.4	0.4	1.4	-0.2	0.8	-0.7	-0.1	-1.2	0.2
Intermittent access day 15 total infusions	0.1	0.2	0.6	-0.5	-0.1	0.3	0.0	-0.8	-0.3
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.9	-0.0	0.5	-0.4	-0.0	-0.9	0.4
Intermittent access total infusions	0.3	0.4	1.6	-0.4	0.5	-0.3	-0.1	-1.3	0.4
Intermittent access day 1 locomotion	1.2	1.2	2.3	0.7	1.5	-1.4	1.3	-0.5	0.8
Intermittent access day 15 total locomotion	0.5	0.5	1.0	-0.6	0.9	-1.0	0.9	-0.3	0.5
Intermittent access total locomotion	1.1	1.2	2.4	0.2	1.6	-1.5	1.4	-0.2	0.7
Intermittent access standard deviation	0.3	0.3	0.8	0.2	0.4	-0.5	0.9	0.2	0.5
Left kidney weight	0.3	0.7	2.5	-0.1	0.4	-0.1	-0.5	-1.2	1.6
Right kidney weight	0.3	0.8	2.5	0.3	1.6	-1.2	0.6	0.7	0.4
Cocaine induced anxiety	0.7	0.8	2.2	1.5	1.0	-0.8	0.3	0.5	0.6
Post-drug Anxiety	0.6	0.6	2.3	1.5	0.4	-0.3	-0.2	0.1	1.1
Baseline Anxiety	0.6	0.6	1.2	-0.8	-1.1	1.0	-0.8	-0.4	-0.2
Tail length	0.4	1.3	3.6	-0.1	1.2	-1.1	1.9	1.2	-0.3
Length with tail	0.8	3.1	5.5	0.7	1.9	-1.8	2.2	2.3	-0.8
Length without tail	0.1	0.3	0.8	0.1	0.7	-0.7	0.3	0.9	-0.2
Times rat made contact with spout	2.1	2.4	12.2	-3.5	-1.0	0.8	-0.3	-0.6	-0.3
Lifetime Intake	0.5	0.6	2.7	-0.3	0.2	0.0	-0.4	-1.7	0.8
Liver weight, left	0.5	0.7	1.3	1.1	1.1	-1.0	0.8	0.5	0.1
Liver weight, right	1.6	2.7	4.3	1.4	1.8	-2.0	1.6	2.1	-0.3
Locomotor activity	0.4	0.6	1.1	0.3	-0.8	1.0	-1.0	-0.9	-0.0
Locomotor testing distance	0.4	0.6	1.3	-0.2	-1.0	1.2	-0.7	-0.9	-0.2
Locomotor testing rearing	0.1	0.1	0.6	-0.1	-0.0	0.1	0.8	0.0	-0.3
Locomotion in novel chamber	0.7	0.8	1.5	1.2	0.8	-0.9	0.6	-0.2	1.2
Locomotion in novel chamber post-restriction	0.5	0.6	1.0	0.8	0.8	-0.7	1.0	0.7	-0.0
Fecal boli incidents, locomotor time 1	1.0	1.1	2.0	-1.1	-1.2	1.4	-0.7	0.4	-1.1
Change in fecal boli incidents, locomotor task	4.1	3.9	6.7	1.7	1.8	-2.0	2.4	2.6	-0.9
Time >=10cm from walls, locomotor time 1	2.2	2.2	4.2	-0.0	-2.1	1.9	-1.1	0.8	-1.9
Bouts of movement, locomotor time 1	1.1	1.2	3.0	-1.7	-1.1	0.9	-0.7	0.1	-1.2
Total resting periods, locomotor time 1	1.9	2.0	4.0	-2.0	-1.7	1.6	-0.9	0.0	-1.4
Rest time, locomotor task time 1	1.1	1.2	3.0	-0.6	-1.5	1.7	-0.7	-0.1	-0.9
Distance moved, locomotor task time 1	0.8	0.9	1.5	1.1	1.1	-1.2	0.1	-0.2	1.1
Vertical activity count, locomotor time 1	0.2	0.2	0.6	0.4	0.6	-0.8	0.0	0.4	0.3
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.5	1.2	0.7	-0.6	0.7	0.9	0.6
Bouts of movement, locomotor time 2	1.2	1.3	4.1	-0.8	-0.2	0.4	0.2	1.7	-2.0
Total resting periods, locomotor time 2	1.1	1.2	3.4	-0.4	0.2	-0.0	0.4	1.8	-1.9
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	0.0	0.1	0.4	0.2	0.1
Distance moved, locomotor task time 2	1.0	1.2	2.6	1.6	1.2	-1.1	0.0	-0.4	1.4
Vertical activity count, locomotor time 2	0.3	0.4	1.6	0.6	0.1	-0.1	-0.4	-0.3	1.2
Light reinforcement 1	0.2	0.4	1.1	-0.9	0.3	-0.3	0.4	-1.0	0.3
Light reinforcement 2	0.4	0.6	1.6	-0.5	-0.4	0.3	-1.1	-1.2	0.1
Bone: marrow area	0.1	0.1	0.3	-0.4	-0.5	0.3	-0.2	-0.5	-0.0
Bone: maximum diameter	0.1	0.2	0.5	-0.7	-0.0	-0.2	-0.2	-0.6	0.4
Bone: maximum force	0.5	0.8	2.1	1.0	-0.5	0.5	-1.4	-0.8	0.6
Bone: maximum moment	0.4	0.8	2.0	1.0	-0.6	0.6	-1.4	-0.9	0.5
Mean time between licks in bursts	0.2	0.3	0.7	0.9	-0.4	0.4	-0.8	0.1	-0.2
Mean num. licks in bursts	1.7	2.1	3.9	-2.0	-1.2	1.2	-0.8	-1.7	1.5
Cd content in liver	0.1	0.1	0.3	0.3	-0.1	0.3	-0.1	0.6	-0.1
Co content in liver	2.7	3.1	8.1	-2.8	-1.7	1.8	-1.0	-0.2	-1.8
Cu content in liver	0.2	0.2	0.8	-0.3	-0.0	0.1	-0.0	0.6	-0.9
Fe content in liver	0.7	0.8	2.0	0.2	-0.9	0.9	-0.4	-1.0	1.4
K content in liver	0.8	0.8	1.4	-0.3	1.1	-1.1	1.2	0.7	-0.2
Mg content in liver	0.5	0.6	1.1	-0.4	0.8	-0.7	1.0	-0.5	0.9
Mn content in liver	0.3	0.3	1.2	-1.1	0.4	-0.4	0.6	0.2	-0.2
Na content in liver	0.8	0.8	2.1	-0.6	1.0	-0.9	0.0	-0.9	1.4
Rb content in liver	0.3	0.3	0.7	-0.8	-0.4	0.6	-0.2	-0.8	0.4
Se content in liver	0.4	0.5	0.9	0.3	0.8	-0.7	0.9	-0.1	1.0
Sr content in liver	1.3	1.2	1.9	0.9	1.4	-1.3	1.0	1.3	-0.5
Zn content in liver	0.9	1.0	2.9	0.3	1.2	-1.1	1.7	0.6	0.1
Bone: minimum diameter	0.0	0.1	0.1	-0.3	-0.4	0.2	-0.3	-0.2	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.3	-0.2	0.1	0.4	-0.1	0.5
Time in novel zone, hab. session 1	0.4	0.4	0.8	0.9	0.7	-0.6	0.5	0.8	-0.3
Total zone transitions, hab. session 1	0.2	0.2	0.7	0.5	0.3	-0.3	0.8	0.5	-0.1
Total locomotion distance, hab. session 1	0.4	0.6	1.7	0.7	0.6	-0.7	1.3	0.3	0.6
Locomotion velocity, hab. session 1	0.3	0.5	1.3	0.3	0.8	-0.8	1.1	0.3	0.2
Time in familiar zone, hab. session 2	1.9	1.9	4.2	-0.8	-1.3	1.2	-1.5	-2.1	1.1
Time in novel zone, hab. session 2	2.3	2.3	4.7	1.2	1.4	-1.3	1.8	2.2	-0.7
Total zone transitions, hab. session 2	0.4	0.6	1.2	-0.8	-1.1	0.9	-0.4	-0.7	-0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.6	-0.5	-0.0	-0.1	0.8	0.0	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.6	-0.3	0.2	0.5	-0.2	-0.2
Novel to familiar place preference ratio	1.1	1.2	2.6	1.6	1.1	-1.0	0.4	1.4	-0.3
Novelty place preference	1.1	1.1	2.7	1.6	1.1	-1.0	0.2	1.2	-0.3
Time in novel zone, NPP test	0.9	1.0	2.3	1.5	0.9	-0.8	0.3	1.3	-0.3
Total zone transitions, NPP test	0.2	0.3	0.6	-0.8	-0.3	0.2	0.7	0.2	-0.7
Total locomotion distance, NPP test	0.3	0.4	1.5	-0.4	0.3	-0.4	1.2	0.5	-0.6
Locomotion velocity, NPP test	0.2	0.2	0.6	-0.7	0.2	-0.2	0.8	-0.2	-0.2
Intraocular pressure	1.0	1.4	2.6	0.7	-1.6	1.6	-1.2	-0.0	-1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.8	0.4	0.4	-0.4	-0.1	-0.3	0.9
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	-0.2	0.1	0.0	-0.8	-0.6	0.6
Parametrial fat weight	0.1	0.2	0.7	0.8	0.2	-0.1	-0.3	0.2	-0.4
Pavlov. Cond. lever latency	1.0	1.2	2.1	1.5	1.3	-1.3	0.9	0.9	0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	-0.6	0.5	-0.5	0.5	0.5	-0.7
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	-0.0	0.5	-0.4	0.5	0.5	-0.9
Pavlov. Cond. index score	0.2	0.2	0.7	-0.8	-0.3	0.3	-0.0	-0.1	-0.8
Pavlov. Cond. latency score	0.2	0.3	0.9	-0.8	-0.3	0.3	-0.0	0.0	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-1.0	-0.5	0.5	-0.3	-0.2	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.3	0.2	-0.2	-0.2	0.4
Pavlov. Cond. intertrial magazine entries	1.3	1.6	3.3	-0.8	-1.8	1.8	-1.2	-1.0	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.3	-1.1	-0.4	0.4	-0.1	-0.1	-1.0
Pavlov. Cond. response bias	0.3	0.4	1.0	-1.0	-0.6	0.6	-0.4	-0.6	-0.1
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.8	0.5	-0.6	0.2	-0.1	1.0
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	0.0	-0.5	0.4	-0.9	-0.9	0.0
Pavlov. Cond. change in total contacts	0.7	0.9	3.2	-1.0	-0.2	0.1	0.1	1.1	-1.8
Pavlov. Cond. index score	0.2	0.2	0.4	-0.6	-0.4	0.4	-0.4	-0.2	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.3	-0.1	-0.4
Pavlov. Cond. lever contacts	0.7	0.9	2.9	-1.2	-0.2	0.2	0.4	1.0	-1.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	-0.1	0.1	0.3	0.1	0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.5	4.0	2.0	1.0	-1.0	0.8	0.3	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	-0.2	-0.5
Pavlov. Cond. response bias	0.5	0.7	2.4	-1.3	-0.4	0.3	-0.1	0.3	-1.6
Time in closed arm before self-admin	1.1	1.3	2.6	0.6	1.6	-1.6	1.3	0.6	0.4
Time in closed arm after self-admin	2.0	2.0	3.8	0.7	1.9	-2.0	1.3	1.5	-0.4
Time in open arm before self-admin	1.4	1.6	3.3	-0.4	-1.7	1.8	-1.1	-0.3	-1.4
Time in open arm after self-admin	0.8	0.9	2.1	0.2	-1.2	1.1	-0.6	-1.4	0.3
Bone: periosteal estimation	0.1	0.1	0.2	-0.4	-0.3	0.1	-0.4	-0.4	0.1
Bone: periosteal perimeter	0.2	0.4	0.8	-0.9	0.4	-0.6	0.4	0.6	-0.5
Bone: post-yield work	0.2	0.3	0.7	0.2	0.8	-0.5	0.8	0.2	0.1
Progressive ratio test 1 active lever presses	1.5	1.6	3.6	0.6	1.9	-1.8	1.1	-0.7	0.8
Progressive ratio test 1 breakpoint	1.8	1.9	4.6	0.6	2.1	-2.0	1.3	-0.4	0.8
Progressive ratio test 1 inactive lever presses	0.8	0.9	2.3	0.2	1.5	-1.4	0.9	-0.3	0.5
Progressive ratio test 2 active lever presses	0.6	0.6	1.2	0.8	1.1	-1.0	0.1	-0.8	0.5
Progressive ratio test 2 breakpoint	0.5	0.5	1.0	0.5	1.0	-0.9	-0.1	-0.9	0.6
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.1	0.6	0.5	-0.4	0.0	-1.0	1.0
Incentive Sensitization - Responses	0.5	0.6	1.2	1.0	1.0	-1.1	0.1	-0.1	0.0
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	1.0	1.1	-1.2	0.1	-0.0	-0.0
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.6	-0.0	-0.6	0.7	-1.3	-0.9	0.8
Progressive ratio	0.9	1.0	2.4	-1.1	0.3	-0.2	1.6	-0.2	1.5
Food seeking constrained by brief footshock	2.9	3.6	8.0	-2.8	-1.8	1.8	-1.6	-2.0	0.5
Seeking ratio, punishment vs. effort	1.6	2.0	4.7	-1.0	-1.4	1.3	-2.2	-0.6	-1.5
Retroperitoneal fat weight	6.0	19.6	32.4	5.7	5.2	-5.0	3.9	4.1	1.0
Reaction time number correct	0.0	0.0	0.2	-0.4	-0.1	0.2	-0.1	-0.1	-0.1
Reaction time mean minus median	1.1	1.5	3.9	0.9	-0.6	0.6	-0.5	-1.7	2.0
Reaction time mean minus median AUC	1.2	1.6	2.6	1.5	-0.6	0.8	-1.1	-1.6	1.6
Reaction time num false alarms	2.0	2.7	9.3	-1.3	-1.2	1.5	-0.7	1.2	-3.0
Reaction time num false alarms AUC	2.1	2.9	10.5	-1.4	-1.1	1.4	-0.4	1.2	-3.2
Reaction time trials correct on left	0.0	0.0	0.2	-0.4	-0.1	0.2	-0.1	-0.1	-0.1
Reaction time trials on left	0.0	0.0	0.1	-0.3	-0.2	0.3	-0.2	-0.2	-0.1
Reaction time mean	0.7	0.9	2.6	1.6	-0.5	0.5	-0.6	-1.0	1.1
Reaction time mean AUC	0.5	0.6	2.2	1.5	-0.3	0.3	-0.3	-0.7	0.9
Median of all reaction times	0.5	0.7	2.7	1.7	-0.4	0.4	-0.6	-0.6	0.7
Reaction time omissions	0.8	1.1	2.7	1.6	-1.2	1.3	-0.4	-0.7	0.3
Reaction time false alarm rate	1.2	1.7	6.9	-0.9	-0.6	0.8	-0.2	1.2	-2.6
Reaction time premature initiation rate	1.1	1.5	4.7	-2.2	0.3	-0.5	1.5	0.9	-1.1
Reaction time premature initiations	0.9	1.2	4.7	-2.2	0.0	-0.2	1.2	0.6	-1.0
Std. dev. reaction times	0.9	1.3	2.9	1.2	-0.7	0.6	-0.5	-1.4	1.7
Reaction time trials completed	0.0	0.0	0.1	-0.3	-0.2	0.3	-0.2	-0.2	-0.1
Reaction time trials AUC	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.3	-0.4	0.1
Run reversals in cocaine runway, females	0.6	0.6	1.6	-0.5	1.3	-1.0	0.2	0.8	0.0
Run reversals in cocaine runway, males	0.3	0.3	0.8	-0.6	0.4	-0.6	-0.2	0.5	-0.9
Latency to leave start box in cocaine runway	0.7	0.7	1.2	-1.1	-0.6	1.0	-1.1	-0.9	0.3
Latency to leave start box in cocaine runway, F	1.6	1.8	3.3	-1.8	-1.2	1.7	-1.4	-1.0	-0.5
Latency to leave start box in cocaine runway, M	0.3	0.2	0.7	0.2	0.8	-0.7	0.1	0.2	0.5
Std. dev. time between licks in bursts	0.4	0.4	1.3	0.3	0.1	-0.0	0.5	1.2	-0.9
Total sessions with >9 infusions	0.2	0.2	0.7	-0.3	-0.0	0.3	-0.1	-0.9	0.4
Short access day 1 total inactive lever presses	0.8	0.9	1.8	0.3	1.3	-1.2	1.3	-0.2	0.6
Short access day 10 total inactive lever presses	0.9	1.0	4.2	1.2	0.3	-0.3	0.5	-0.3	2.0
Short access day 1 total infusions	0.3	0.3	1.0	0.6	0.5	-0.4	-0.2	-1.0	0.6
Short access day 10 total infusions	0.7	0.8	2.9	-0.5	-0.3	0.4	-0.9	-1.7	0.7
Short access total infusions	0.9	1.1	3.4	0.4	0.0	0.2	-1.0	-1.9	1.3
Short access day 1 locomotion	0.4	0.5	0.8	-0.2	0.9	-0.8	0.6	-0.4	0.8
Short access day 10 total locomotion	0.8	0.9	1.9	0.7	1.1	-0.9	1.4	-0.0	0.9
Short access total locomotion	1.5	1.6	2.4	1.0	1.5	-1.4	1.4	-0.1	1.6
One hour access (0.3 mA shock)	0.4	0.4	1.0	-0.4	-0.1	-0.0	-1.0	-1.0	0.7
Compulsive drug intake	0.1	0.1	0.6	0.1	0.2	-0.2	-0.2	0.8	0.2
One hour access (shock baseline)	0.2	0.3	0.9	-0.8	0.1	-0.2	-0.1	-0.9	0.1
Social response proportion	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.4	-0.2	0.3
Social responses	2.0	2.5	4.3	1.0	2.1	-2.0	2.0	0.9	1.0
Social time	0.8	1.0	4.3	0.9	0.4	-0.5	0.2	-0.8	2.1
Soleus weight	0.6	1.9	5.6	-2.4	-0.6	0.6	0.6	0.4	-2.1
Bone: stiffness	0.2	0.3	1.1	1.0	-0.1	-0.0	-0.7	0.1	0.3
Tibialis anterior weight	0.0	0.1	0.5	-0.2	-0.2	0.2	-0.1	-0.7	-0.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.2	0.7	-0.3	0.1	0.4	0.8	-1.1
Time to tail flick, vehicle, after self-admin	2.4	2.5	7.9	0.3	1.8	-1.7	2.8	0.9	0.5
Time to tail flick, test, before self-admin	0.3	0.3	1.2	-0.5	-0.2	-0.2	1.1	0.0	-0.0
Time to tail flick, test, after self-admin	2.9	3.0	9.7	-0.2	1.6	-1.8	3.1	1.6	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.5	0.5	-0.3	0.8	-0.2	0.6
Delta time to tail flick, test, before/after SA	0.6	0.6	1.3	-0.4	0.9	-0.8	1.1	0.6	0.1
Tibia length	1.3	3.7	7.4	1.8	2.6	-2.7	1.8	1.1	0.8
Ambulatory time before self-admin	2.4	2.5	3.9	1.1	1.9	-2.0	1.9	1.4	-0.9
Ambulatory time after self-admin	1.4	1.6	3.2	0.8	1.6	-1.8	1.3	1.1	-0.5
Bone: tissue strength	0.2	0.2	0.7	0.8	-0.3	0.4	-0.6	-0.2	0.0
Total heroin consumption	0.7	0.8	2.1	0.0	-0.3	0.2	-0.9	-1.4	1.5
Bone: trabecular number	3.1	4.8	7.5	-1.2	-2.5	2.3	-2.7	-2.6	1.1
Bone: trabecular spacing	0.5	0.7	1.2	0.5	1.0	-0.6	0.9	1.1	-0.6
Bone: trabecular thickness	0.2	0.2	0.9	0.1	-0.3	-0.0	-0.9	-0.4	0.3
Bone: trabecular tissue density	0.2	0.3	1.4	0.2	0.4	-0.4	-0.1	-0.5	1.2
Water consumed over 24 hours	0.5	0.7	3.7	-1.9	-0.2	0.2	0.3	0.0	-0.2
Number of responses in last shaping day	1.1	1.2	2.8	-0.0	0.9	-0.9	1.7	1.2	-1.0