Hub : Genes

LOC120102905

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr5_101794127_101832145 0.02 0.02 3.6e-03 0.02 0.02 0.03 0.02 3.7e-03 2.9e-03 4.5e-04 1.6e-03
2 NAcc gene expression LOC120102905 0.02 0.02 2.2e-03 0.01 0.02 0.01 0.01 2.3e-02 4.6e-03 3.7e-02 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density6.711.211.63.4-3.3
Area under the delay curve4.14.45.72.4-1.8
BMI with tail7.323.826.9-5.24.5
BMI without tail3.16.56.9-2.62.5
Body weight0.93.73.7-1.91.9
Weight adjusted by age0.30.30.3-0.60.5
Bone surface0.00.00.0-0.1-0.0
Bone volume0.50.90.90.9-1.0
Breakpoint value in progressive ratio session1.51.61.8-1.21.3
Number of licking bursts1.11.31.9-1.40.8
Context. condit. distance diff. score0.20.30.30.6-0.5
Locomotion velocity, session 10.40.40.40.6-0.6
Locomotion distance, session 11.41.82.21.2-1.5
Locomotion velocity, session 20.50.60.70.7-0.9
Locomotion distance, session 20.70.91.00.9-1.0
Locomotion velocity, session 30.30.30.40.6-0.6
Locomotion distance, session 30.70.70.9-0.90.7
Stereotopy head waving bouts, day 30.00.10.10.30.1
Stereotopy head waving duration, day 32.22.63.41.8-1.4
Locomotion velocity, session 72.72.93.01.7-1.7
Locomotion distance, session 74.15.25.72.4-2.2
Stereotopy head waving bouts, day 73.13.53.6-1.81.9
Stereotopy head waving duration, day 71.92.32.4-1.51.5
Locomotion velocity, session 80.00.10.10.0-0.3
Locomotion distance, session 80.60.90.91.0-0.9
Degree of sensitization distance2.93.03.31.8-1.6
Degree of sensitization stereotypy5.25.76.1-2.52.3
Conditioned locomotion0.50.60.7-0.80.7
Cocaine response after cond. corrected3.13.53.7-1.91.8
Cocaine response after cond. not corrected3.03.33.6-1.91.8
Cocaine response before conditioning0.00.00.00.2-0.1
Saline control response7.810.211.9-3.42.9
Bone: connectivity density0.81.31.41.1-1.2
Bone: cortical apparent density0.20.30.30.6-0.5
Bone: cortical area1.11.61.9-1.41.2
Bone: cortical porosity0.10.10.1-0.30.3
Bone: cortical porosity1.01.01.2-1.10.9
Bone: cortical thickness0.20.40.4-0.60.6
Bone: cortical thickness0.30.40.6-0.70.5
Bone: cortical tissue density0.20.30.40.6-0.5
Condit. Reinf. active minus inactive responses1.31.51.71.3-1.1
Condit. Reinf. active-inactive response ratio0.00.00.10.3-0.1
Condit. Reinf. active responses1.51.92.11.4-1.3
Condit. Reinf. inactive responses1.21.41.51.2-1.2
Incentive salience index mean0.30.40.40.6-0.6
Condit. Reinf. lever presses0.10.10.2-0.40.3
Condit. Reinf. active minus inactive responses0.10.20.2-0.30.5
Condit. Reinf. active-inactive response ratio0.91.01.0-1.01.0
Condit. Reinf. active responses0.40.50.70.8-0.6
Condit. Reinf. inactive responses6.07.47.82.8-2.6
Condit. Reinf. lever presses2.73.73.8-2.01.9
Condit. Reinf. lever reinforcers received0.20.30.40.6-0.4
Conditioned reinforcement - actives0.00.00.10.2-0.0
Conditioned reinforcement - inactives2.83.13.41.8-1.7
Conditioned locomotion1.11.31.8-0.91.3
Patch foraging indifference point 0 sec8.012.915.5-3.93.2
Patch foraging indifference point AUC1.11.31.6-1.31.0
Delay disc. indifference point, 0s delay5.35.97.02.6-2.2
Delay disc. indifference point, 16s delay2.32.33.41.8-1.1
Delay disc. indifference point, 2s delay3.13.54.52.1-1.6
Delay disc. indifference point, 24s delay2.92.83.41.8-1.5
Delay disc. indifference point, 4s delay2.72.93.61.9-1.5
Delay disc. indifference point, 8s delay2.82.93.61.9-1.5
Indifference point function ln k0.10.10.10.3-0.2
Indifference point function log k0.10.10.10.3-0.2
Patch foraging total patch changes 0 sec7.812.615.1-3.93.2
Patch foraging total patch changes 12 sec4.35.67.1-2.72.0
Patch foraging total patch changes 18 sec2.32.93.6-1.91.5
Patch foraging total patch changes 24 sec6.88.310.5-3.22.5
Patch foraging total patch changes 6 sec10.315.218.9-4.43.4
Patch foraging time to switch 0 sec3.96.16.32.5-2.4
Patch foraging water rate 0 sec7.512.113.3-3.63.3
Patch foraging water rate 12 sec7.511.411.5-3.43.4
Patch foraging water rate 18 sec3.14.25.0-2.21.8
Patch foraging water rate 24 sec1.92.73.1-1.81.5
Patch foraging water rate 6 sec2.74.04.4-2.11.9
Seeking ratio, delayed vs. immediate footshock2.22.52.8-1.71.5
Distance traveled before self-admin0.00.00.00.00.0
Distance traveled after self-admin0.20.20.30.6-0.3
Extensor digitorum longus weight2.08.18.32.9-2.8
Bone: elastic displacement4.24.75.02.2-2.1
Bone: elastic work1.11.41.51.1-1.2
Bone: endosteal estimation1.22.63.1-1.81.4
Bone: endosteal perimeter0.40.91.0-1.00.9
Epididymis fat weight0.30.60.8-0.90.7
Delta time in closed arm before/after self-admin0.00.00.0-0.1-0.1
Delta time in open arm before/after self-admin0.10.10.1-0.40.3
Diff in mean of infusions in LGA sessions0.60.70.8-0.80.9
Delay discount exponential model param3.63.84.9-2.21.6
Extinction: sum of active levers before priming2.62.53.0-1.41.7
Active lever presses in extinction session 64.03.95.0-1.72.2
Bone: final force2.13.43.8-1.91.7
Bone: final moment2.23.63.9-2.01.8
Food consumed during 24 hour testing period0.70.91.01.0-0.9
Glucose0.40.61.00.5-1.0
Heart weight0.40.60.8-0.90.6
Delay discount hyperbolic model param3.53.74.9-2.21.6
Intermittent access intake day 1-15 change0.40.40.50.7-0.5
Intermittent access intake escalation1.11.11.71.3-0.8
Intermittent access intake escalation 20.10.10.10.10.4
Intermitt. access day 1 inactive lever presses0.30.30.4-0.40.6
Intermitt. access day 15 inactive lever presses0.10.10.20.2-0.4
Intermitt. access escalation Index0.50.40.50.7-0.6
Intermittent access day 1 total infusions0.40.50.50.7-0.7
Intermittent access day 15 total infusions1.51.62.01.4-1.1
Intermittent access terminal intake (last 3 days)2.32.52.61.6-1.5
Intermittent access total infusions1.61.82.41.5-1.1
Intermittent access day 1 locomotion0.00.00.10.10.3
Intermittent access day 15 total locomotion0.10.10.2-0.40.2
Intermittent access total locomotion0.00.00.0-0.10.2
Intermittent access standard deviation0.60.71.11.0-0.5
Left kidney weight2.77.58.9-3.02.5
Right kidney weight2.15.97.2-2.72.1
Cocaine induced anxiety1.11.31.70.9-1.3
Post-drug Anxiety0.50.60.80.6-0.9
Baseline Anxiety0.30.30.4-0.50.7
Tail length0.92.83.71.9-1.4
Length with tail0.82.93.71.9-1.5
Length without tail0.00.00.0-0.10.1
Times rat made contact with spout2.32.72.7-1.61.7
Lifetime Intake3.13.64.22.0-1.7
Liver weight, left1.22.02.01.4-1.4
Liver weight, right0.30.50.60.6-0.8
Locomotor activity0.61.01.0-0.91.0
Locomotor testing distance0.00.00.10.3-0.0
Locomotor testing rearing0.30.50.50.7-0.6
Locomotion in novel chamber0.10.10.10.4-0.3
Locomotion in novel chamber post-restriction0.40.50.6-0.60.8
Fecal boli incidents, locomotor time 10.20.20.30.6-0.3
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.0
Time >=10cm from walls, locomotor time 10.00.00.00.00.2
Bouts of movement, locomotor time 10.60.60.9-0.61.0
Total resting periods, locomotor time 11.11.21.6-0.91.3
Rest time, locomotor task time 10.10.10.20.10.4
Distance moved, locomotor task time 10.60.70.90.6-1.0
Vertical activity count, locomotor time 10.10.20.30.0-0.5
Time >=10cm from walls, locomotor time 20.30.40.60.3-0.8
Bouts of movement, locomotor time 20.80.91.1-1.00.8
Total resting periods, locomotor time 20.50.60.6-0.80.7
Rest time, locomotor task time 20.10.10.20.40.2
Distance moved, locomotor task time 20.70.81.30.6-1.1
Vertical activity count, locomotor time 22.52.73.61.3-1.9
Light reinforcement 16.511.812.23.5-3.4
Light reinforcement 22.53.43.51.8-1.9
Bone: marrow area1.12.53.0-1.71.4
Bone: maximum diameter3.05.56.1-2.52.2
Bone: maximum force1.62.73.0-1.71.5
Bone: maximum moment1.73.03.2-1.81.6
Mean time between licks in bursts6.18.59.33.1-2.8
Mean num. licks in bursts0.10.20.3-0.10.6
Cd content in liver1.82.02.1-1.51.3
Co content in liver2.12.52.8-1.71.5
Cu content in liver1.92.33.0-1.71.3
Fe content in liver0.40.40.5-0.60.7
K content in liver0.10.10.2-0.50.2
Mg content in liver0.40.40.6-0.80.6
Mn content in liver0.70.80.80.9-0.9
Na content in liver0.00.00.0-0.1-0.2
Rb content in liver0.81.01.11.0-1.0
Se content in liver0.10.10.2-0.20.4
Sr content in liver0.00.00.00.0-0.0
Zn content in liver0.20.20.3-0.50.4
Bone: minimum diameter3.15.86.7-2.62.2
Time in familiar zone, hab. session 10.00.00.1-0.3-0.0
Time in novel zone, hab. session 10.10.10.20.5-0.2
Total zone transitions, hab. session 10.10.10.20.3-0.4
Total locomotion distance, hab. session 10.00.00.00.0-0.1
Locomotion velocity, hab. session 10.00.00.00.0-0.1
Time in familiar zone, hab. session 20.00.00.00.2-0.2
Time in novel zone, hab. session 20.10.10.10.4-0.4
Total zone transitions, hab. session 21.21.51.71.1-1.3
Total locomotion distance, hab. session 20.70.91.00.9-1.0
Locomotion velocity, hab. session 20.30.40.50.5-0.7
Novel to familiar place preference ratio1.31.41.5-1.21.1
Novelty place preference1.61.71.8-1.31.3
Time in novel zone, NPP test1.11.11.2-1.11.0
Total zone transitions, NPP test2.02.83.01.6-1.7
Total locomotion distance, NPP test0.40.60.60.7-0.8
Locomotion velocity, NPP test0.71.01.01.0-1.0
Intraocular pressure0.40.50.50.7-0.7
Delta distance traveled before/after self-admin0.60.70.90.7-0.9
Delta ambulatory time before/after self-admin1.21.31.90.8-1.4
Parametrial fat weight1.93.84.4-2.11.8
Pavlov. Cond. lever latency0.10.10.10.3-0.4
Pavlov. Cond. magazine entry latency1.01.31.61.3-1.0
Pavlov. Cond. change in total contacts0.30.40.60.8-0.4
Pavlov. Cond. index score0.70.91.11.0-0.8
Pavlov. Cond. latency score0.10.10.20.4-0.3
Pavlov. Cond. lever contacts0.30.30.30.6-0.5
Pavlov. Cond. magazine entry number1.82.32.7-1.61.3
Pavlov. Cond. intertrial magazine entries6.37.78.62.9-2.6
Pavlov. Cond. lever-magazine prob. diff.0.91.11.31.1-1.0
Pavlov. Cond. response bias1.72.02.41.6-1.3
Pavlov. Cond. lever latency4.15.66.22.5-2.2
Pavlov. Cond. magazine entry latency0.30.40.4-0.60.6
Pavlov. Cond. change in total contacts2.02.83.0-1.71.6
Pavlov. Cond. index score2.43.13.4-1.81.7
Pavlov. Cond. latency score3.13.94.1-2.01.9
Pavlov. Cond. lever contacts4.86.67.3-2.72.4
Pavlov. Cond. magazine entry number0.10.20.20.4-0.4
Pavlov. Cond. intertrial magazine entries8.110.511.53.4-3.1
Pavlov. Cond. lever-magazine prob. diff.2.12.72.9-1.71.6
Pavlov. Cond. response bias2.02.72.9-1.71.6
Time in closed arm before self-admin0.30.30.5-0.40.7
Time in closed arm after self-admin0.10.10.10.4-0.0
Time in open arm before self-admin0.50.60.60.8-0.7
Time in open arm after self-admin0.20.20.2-0.50.4
Bone: periosteal estimation1.63.33.9-2.01.7
Bone: periosteal perimeter0.50.91.0-1.00.9
Bone: post-yield work2.73.74.3-2.11.8
Progressive ratio test 1 active lever presses4.44.64.92.1-2.2
Progressive ratio test 1 breakpoint4.24.45.02.0-2.2
Progressive ratio test 1 inactive lever presses1.31.42.10.8-1.4
Progressive ratio test 2 active lever presses2.02.12.61.3-1.6
Progressive ratio test 2 breakpoint1.21.31.70.9-1.3
Progressive ratio test 2 inactive lever presses0.20.20.50.1-0.7
Incentive Sensitization - Responses1.11.22.00.5-1.4
Incentive Sensitization - Breakpoint1.31.32.10.7-1.4
Sum of active levers in priming session hrs 5-60.60.60.90.9-0.5
Progressive ratio1.11.21.61.3-1.0
Food seeking constrained by brief footshock15.118.520.34.5-4.1
Seeking ratio, punishment vs. effort1.41.71.71.3-1.3
Retroperitoneal fat weight3.912.715.9-4.03.1
Reaction time number correct0.00.00.10.20.0
Reaction time mean minus median0.10.10.10.3-0.3
Reaction time mean minus median AUC1.01.31.41.1-1.2
Reaction time num false alarms1.41.92.5-1.61.2
Reaction time num false alarms AUC1.41.92.2-1.51.2
Reaction time trials correct on left0.00.00.10.20.0
Reaction time trials on left0.00.00.10.20.1
Reaction time mean0.10.20.20.5-0.4
Reaction time mean AUC0.10.10.20.4-0.4
Median of all reaction times0.20.20.30.5-0.4
Reaction time omissions0.20.30.4-0.30.6
Reaction time false alarm rate1.92.63.4-1.81.4
Reaction time premature initiation rate0.60.81.0-1.00.8
Reaction time premature initiations0.20.30.3-0.50.5
Std. dev. reaction times0.20.30.30.5-0.5
Reaction time trials completed0.00.00.10.20.1
Reaction time trials AUC0.00.00.00.20.1
Run reversals in cocaine runway, females0.60.50.6-0.80.7
Run reversals in cocaine runway, males0.10.10.1-0.30.2
Latency to leave start box in cocaine runway0.50.50.8-0.90.5
Latency to leave start box in cocaine runway, F1.71.92.3-1.51.2
Latency to leave start box in cocaine runway, M0.20.20.30.3-0.5
Std. dev. time between licks in bursts0.00.00.10.1-0.2
Total sessions with >9 infusions4.65.05.62.4-2.1
Short access day 1 total inactive lever presses0.20.20.30.2-0.6
Short access day 10 total inactive lever presses0.91.01.1-1.10.9
Short access day 1 total infusions2.93.13.21.8-1.7
Short access day 10 total infusions5.66.27.32.7-2.2
Short access total infusions5.35.96.32.5-2.3
Short access day 1 locomotion0.91.01.11.0-0.9
Short access day 10 total locomotion2.02.23.1-1.11.8
Short access total locomotion0.90.91.31.1-0.7
One hour access (0.3 mA shock)0.40.40.70.8-0.4
Compulsive drug intake1.81.81.9-1.31.4
One hour access (shock baseline)3.94.65.52.3-1.9
Social response proportion1.01.11.11.0-1.1
Social responses2.73.53.81.9-1.8
Social time2.33.13.41.8-1.7
Soleus weight0.30.81.0-1.00.8
Bone: stiffness1.11.82.0-1.41.2
Tibialis anterior weight3.712.814.9-3.93.3
Time to tail flick, vehicle, before self-admin0.00.00.0-0.2-0.0
Time to tail flick, vehicle, after self-admin0.00.00.10.00.2
Time to tail flick, test, before self-admin0.40.40.60.3-0.8
Time to tail flick, test, after self-admin0.10.10.1-0.2-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.20.4-0.1
Delta time to tail flick, test, before/after SA0.30.30.3-0.60.5
Tibia length0.30.70.9-1.00.7
Ambulatory time before self-admin0.10.10.1-0.30.3
Ambulatory time after self-admin0.10.20.20.5-0.3
Bone: tissue strength1.81.81.9-1.41.3
Total heroin consumption0.91.11.3-1.10.9
Bone: trabecular number5.07.88.02.8-2.8
Bone: trabecular spacing3.14.04.0-2.02.0
Bone: trabecular thickness0.50.60.70.8-0.7
Bone: trabecular tissue density2.84.04.22.1-1.9
Water consumed over 24 hours0.20.20.3-0.50.4
Number of responses in last shaping day0.00.00.00.0-0.1