LOC120101883

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC120101883 0.05 0.03 3.6e-05 0.03 0.04 0.04 0.03 5.4e-04 1.5e-04 3.0e-04 3.7e-04
2 IL gene expression LOC120101883 0.29 0.15 2.9e-03 0.09 0.08 0.1 0.09 3.7e-03 4.7e-03 2.1e-03 4.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.03.65.6-2.41.3
Area under the delay curve0.30.40.90.90.1
BMI with tail1.24.35.8-2.41.6
BMI without tail2.111.413.3-3.63.1
Body weight13.760.170.8-8.47.0
Weight adjusted by age0.10.40.8-0.90.2
Bone surface2.85.47.3-2.71.9
Bone volume0.91.82.9-1.70.8
Breakpoint value in progressive ratio session0.10.20.4-0.20.7
Number of licking bursts0.30.91.3-1.10.6
Context. condit. distance diff. score5.06.06.9-2.32.6
Locomotion velocity, session 10.40.50.70.9-0.5
Locomotion distance, session 11.72.22.81.7-1.3
Locomotion velocity, session 20.20.20.40.6-0.3
Locomotion distance, session 21.11.52.21.5-0.9
Locomotion velocity, session 30.40.40.6-0.60.8
Locomotion distance, session 30.00.00.0-0.20.1
Stereotopy head waving bouts, day 31.21.42.1-1.50.8
Stereotopy head waving duration, day 30.30.40.70.4-0.8
Locomotion velocity, session 70.40.40.80.90.2
Locomotion distance, session 70.20.20.30.50.3
Stereotopy head waving bouts, day 70.10.10.20.4-0.2
Stereotopy head waving duration, day 70.20.20.30.6-0.3
Locomotion velocity, session 80.10.10.2-0.20.5
Locomotion distance, session 81.21.72.2-1.11.5
Degree of sensitization distance0.70.81.31.1-0.5
Degree of sensitization stereotypy0.10.10.30.5-0.2
Conditioned locomotion0.10.10.30.1-0.5
Cocaine response after cond. corrected0.10.10.3-0.2-0.5
Cocaine response after cond. not corrected0.00.00.0-0.2-0.1
Cocaine response before conditioning0.40.50.9-0.21.0
Saline control response3.65.05.4-2.32.1
Bone: connectivity density4.77.59.6-3.12.3
Bone: cortical apparent density0.10.10.20.4-0.0
Bone: cortical area2.43.95.1-1.72.3
Bone: cortical porosity0.00.00.0-0.20.2
Bone: cortical porosity0.10.10.10.4-0.1
Bone: cortical thickness2.33.94.8-1.72.2
Bone: cortical thickness2.83.44.1-1.72.0
Bone: cortical tissue density0.10.10.20.5-0.2
Condit. Reinf. active minus inactive responses0.40.40.70.8-0.5
Condit. Reinf. active-inactive response ratio0.10.10.20.4-0.2
Condit. Reinf. active responses0.20.30.60.8-0.1
Condit. Reinf. inactive responses0.30.40.80.9-0.1
Incentive salience index mean0.20.30.50.7-0.2
Condit. Reinf. lever presses0.20.30.60.7-0.1
Condit. Reinf. active minus inactive responses1.82.73.8-1.32.0
Condit. Reinf. active-inactive response ratio0.81.32.1-0.71.5
Condit. Reinf. active responses2.13.04.2-1.32.0
Condit. Reinf. inactive responses0.30.50.5-0.70.7
Condit. Reinf. lever presses0.00.10.10.00.3
Condit. Reinf. lever reinforcers received1.31.82.8-0.91.7
Conditioned reinforcement - actives1.55.86.1-2.52.3
Conditioned reinforcement - inactives0.10.30.5-0.70.3
Conditioned locomotion3.45.05.3-2.22.3
Patch foraging indifference point 0 sec0.10.20.40.0-0.6
Patch foraging indifference point AUC0.71.72.1-1.41.2
Delay disc. indifference point, 0s delay0.30.40.7-0.30.8
Delay disc. indifference point, 16s delay0.10.10.20.50.1
Delay disc. indifference point, 2s delay1.21.42.61.6-0.4
Delay disc. indifference point, 24s delay0.30.50.80.9-0.4
Delay disc. indifference point, 4s delay0.40.50.90.9-0.2
Delay disc. indifference point, 8s delay0.10.10.30.50.2
Indifference point function ln k0.00.10.1-0.20.3
Indifference point function log k0.00.10.1-0.20.3
Patch foraging total patch changes 0 sec0.10.30.50.0-0.7
Patch foraging total patch changes 12 sec0.10.20.3-0.6-0.1
Patch foraging total patch changes 18 sec0.10.20.2-0.4-0.4
Patch foraging total patch changes 24 sec0.00.00.0-0.2-0.1
Patch foraging total patch changes 6 sec0.10.20.4-0.6-0.2
Patch foraging time to switch 0 sec1.03.74.01.9-2.0
Patch foraging water rate 0 sec1.45.15.8-2.42.1
Patch foraging water rate 12 sec0.31.11.4-0.91.2
Patch foraging water rate 18 sec0.20.51.0-0.11.0
Patch foraging water rate 24 sec3.34.74.8-2.22.2
Patch foraging water rate 6 sec0.91.41.5-1.11.2
Seeking ratio, delayed vs. immediate footshock2.43.44.31.6-2.1
Distance traveled before self-admin0.20.40.60.8-0.4
Distance traveled after self-admin0.00.00.10.30.1
Extensor digitorum longus weight5.722.623.9-4.94.6
Bone: elastic displacement0.30.40.5-0.60.7
Bone: elastic work4.45.75.8-2.42.4
Bone: endosteal estimation0.41.01.5-1.20.7
Bone: endosteal perimeter0.51.31.5-1.01.2
Epididymis fat weight0.00.00.00.10.0
Delta time in closed arm before/after self-admin0.70.60.9-0.60.9
Delta time in open arm before/after self-admin3.84.55.02.2-2.0
Diff in mean of infusions in LGA sessions0.10.20.2-0.40.5
Delay discount exponential model param0.50.71.4-1.20.1
Extinction: sum of active levers before priming0.20.30.40.7-0.3
Active lever presses in extinction session 60.10.10.1-0.30.2
Bone: final force2.43.94.0-2.01.9
Bone: final moment1.82.93.0-1.71.6
Food consumed during 24 hour testing period0.10.20.4-0.6-0.3
Glucose2.03.24.02.0-1.6
Heart weight0.71.11.6-0.81.3
Delay discount hyperbolic model param0.50.61.2-1.10.0
Intermittent access intake day 1-15 change0.21.11.7-1.30.7
Intermittent access intake escalation0.21.01.6-1.30.7
Intermittent access intake escalation 20.00.10.1-0.0-0.3
Intermitt. access day 1 inactive lever presses0.00.10.2-0.5-0.0
Intermitt. access day 15 inactive lever presses0.10.81.30.4-1.2
Intermitt. access escalation Index0.00.10.10.30.1
Intermittent access day 1 total infusions0.10.20.40.60.1
Intermittent access day 15 total infusions0.10.20.4-0.40.6
Intermittent access terminal intake (last 3 days)0.00.00.1-0.00.2
Intermittent access total infusions0.10.10.10.20.3
Intermittent access day 1 locomotion0.20.30.60.8-0.0
Intermittent access day 15 total locomotion0.20.91.3-0.81.1
Intermittent access total locomotion0.10.10.20.20.4
Intermittent access standard deviation0.00.20.4-0.3-0.6
Left kidney weight5.644.855.1-7.45.9
Right kidney weight5.135.444.0-6.65.2
Cocaine induced anxiety0.00.10.10.30.2
Post-drug Anxiety2.22.53.71.9-1.1
Baseline Anxiety1.93.23.61.9-1.7
Tail length7.339.343.2-6.66.0
Length with tail19.385.796.8-9.88.6
Length without tail6.936.244.9-6.75.2
Times rat made contact with spout0.70.81.0-1.00.8
Lifetime Intake0.10.10.30.5-0.1
Liver weight, left2.13.66.3-2.51.0
Liver weight, right2.84.96.7-2.61.8
Locomotor activity3.86.07.5-2.12.7
Locomotor testing distance0.61.51.5-1.21.2
Locomotor testing rearing0.00.10.2-0.0-0.5
Locomotion in novel chamber1.62.12.1-1.51.4
Locomotion in novel chamber post-restriction1.23.84.2-1.82.1
Fecal boli incidents, locomotor time 11.12.93.1-1.61.8
Change in fecal boli incidents, locomotor task0.30.30.40.5-0.6
Time >=10cm from walls, locomotor time 11.21.52.31.5-0.8
Bouts of movement, locomotor time 11.72.22.4-1.51.4
Total resting periods, locomotor time 11.82.12.1-1.51.4
Rest time, locomotor task time 11.11.81.9-1.41.3
Distance moved, locomotor task time 10.10.30.60.7-0.3
Vertical activity count, locomotor time 10.00.20.3-0.30.5
Time >=10cm from walls, locomotor time 20.10.30.4-0.40.6
Bouts of movement, locomotor time 20.51.82.0-1.41.3
Total resting periods, locomotor time 20.41.51.8-1.31.1
Rest time, locomotor task time 20.10.20.30.5-0.4
Distance moved, locomotor task time 20.10.10.2-0.40.3
Vertical activity count, locomotor time 21.12.63.2-1.81.4
Light reinforcement 10.31.52.71.6-0.5
Light reinforcement 20.20.50.60.7-0.7
Bone: marrow area0.40.91.4-1.20.6
Bone: maximum diameter1.53.13.1-1.81.7
Bone: maximum force1.83.63.7-1.91.9
Bone: maximum moment1.52.93.0-1.71.7
Mean time between licks in bursts0.52.83.11.6-1.8
Mean num. licks in bursts0.00.10.20.4-0.3
Cd content in liver0.20.20.30.30.5
Co content in liver0.40.40.8-0.9-0.1
Cu content in liver0.30.30.40.6-0.5
Fe content in liver0.60.71.1-0.51.0
K content in liver0.00.00.1-0.20.3
Mg content in liver0.70.81.0-1.00.7
Mn content in liver0.30.30.40.4-0.7
Na content in liver1.61.82.0-1.21.4
Rb content in liver3.03.54.42.1-1.6
Se content in liver0.70.81.1-0.71.0
Sr content in liver0.30.30.5-0.70.1
Zn content in liver3.33.95.5-2.31.5
Bone: minimum diameter0.00.10.10.4-0.1
Time in familiar zone, hab. session 10.80.91.40.6-1.2
Time in novel zone, hab. session 10.80.91.1-0.81.1
Total zone transitions, hab. session 10.71.01.81.3-0.5
Total locomotion distance, hab. session 10.40.61.11.0-0.4
Locomotion velocity, hab. session 11.21.62.71.6-0.8
Time in familiar zone, hab. session 20.20.20.30.3-0.5
Time in novel zone, hab. session 20.00.00.10.30.1
Total zone transitions, hab. session 20.40.50.7-0.60.8
Total locomotion distance, hab. session 20.00.10.10.30.0
Locomotion velocity, hab. session 20.00.00.10.30.1
Novel to familiar place preference ratio0.00.00.1-0.00.3
Novelty place preference0.00.00.10.3-0.0
Time in novel zone, NPP test0.00.00.00.20.1
Total zone transitions, NPP test0.00.00.0-0.00.2
Total locomotion distance, NPP test0.10.10.20.40.1
Locomotion velocity, NPP test0.10.10.20.20.4
Intraocular pressure1.62.62.7-1.61.6
Delta distance traveled before/after self-admin0.10.10.1-0.40.2
Delta ambulatory time before/after self-admin0.20.30.40.5-0.6
Parametrial fat weight0.00.00.0-0.2-0.1
Pavlov. Cond. lever latency1.41.72.5-1.61.0
Pavlov. Cond. magazine entry latency1.01.32.0-0.81.4
Pavlov. Cond. change in total contacts0.30.30.70.8-0.0
Pavlov. Cond. index score0.10.10.10.20.4
Pavlov. Cond. latency score0.10.10.20.50.2
Pavlov. Cond. lever contacts1.21.52.11.5-0.9
Pavlov. Cond. magazine entry number0.91.11.70.7-1.3
Pavlov. Cond. intertrial magazine entries1.82.12.31.4-1.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.10.3
Pavlov. Cond. response bias0.50.61.0-0.41.0
Pavlov. Cond. lever latency0.20.30.6-0.80.2
Pavlov. Cond. magazine entry latency1.41.93.21.8-0.8
Pavlov. Cond. change in total contacts0.10.20.50.70.0
Pavlov. Cond. index score0.81.32.21.5-0.6
Pavlov. Cond. latency score0.81.22.11.4-0.6
Pavlov. Cond. lever contacts0.30.40.90.9-0.2
Pavlov. Cond. magazine entry number1.62.13.3-1.80.9
Pavlov. Cond. intertrial magazine entries0.40.80.8-0.90.9
Pavlov. Cond. lever-magazine prob. diff.0.91.42.41.5-0.6
Pavlov. Cond. response bias0.70.91.81.3-0.3
Time in closed arm before self-admin1.42.42.8-1.71.4
Time in closed arm after self-admin3.13.53.7-1.81.9
Time in open arm before self-admin0.10.10.3-0.10.5
Time in open arm after self-admin1.92.12.51.6-1.3
Bone: periosteal estimation1.33.23.3-1.71.8
Bone: periosteal perimeter0.71.52.3-0.81.5
Bone: post-yield work0.20.30.4-0.60.4
Progressive ratio test 1 active lever presses1.22.22.2-1.51.5
Progressive ratio test 1 breakpoint1.22.12.2-1.41.5
Progressive ratio test 1 inactive lever presses0.51.31.7-1.30.9
Progressive ratio test 2 active lever presses1.52.12.2-1.41.5
Progressive ratio test 2 breakpoint1.51.92.0-1.31.4
Progressive ratio test 2 inactive lever presses1.34.05.2-2.31.7
Incentive Sensitization - Responses0.00.00.00.00.0
Incentive Sensitization - Breakpoint0.00.00.00.1-0.1
Sum of active levers in priming session hrs 5-60.00.00.00.0-0.1
Progressive ratio0.31.01.01.0-1.0
Food seeking constrained by brief footshock2.22.84.01.2-2.0
Seeking ratio, punishment vs. effort0.30.60.9-1.00.6
Retroperitoneal fat weight0.10.30.30.6-0.4
Reaction time number correct0.30.91.0-1.00.9
Reaction time mean minus median0.21.12.1-0.11.4
Reaction time mean minus median AUC0.00.30.60.80.3
Reaction time num false alarms0.10.10.20.30.4
Reaction time num false alarms AUC0.10.10.2-0.00.5
Reaction time trials correct on left0.30.91.0-1.00.9
Reaction time trials on left0.30.90.9-1.00.9
Reaction time mean1.22.74.22.0-1.1
Reaction time mean AUC1.23.04.52.1-1.2
Median of all reaction times3.24.96.32.5-1.9
Reaction time omissions0.30.60.91.0-0.4
Reaction time false alarm rate0.10.10.10.40.2
Reaction time premature initiation rate0.10.20.40.10.6
Reaction time premature initiations0.10.40.8-0.20.9
Std. dev. reaction times0.10.40.70.80.3
Reaction time trials completed0.30.90.9-1.00.9
Reaction time trials AUC0.20.60.6-0.80.8
Run reversals in cocaine runway, females1.41.51.51.2-1.2
Run reversals in cocaine runway, males0.00.00.0-0.0-0.0
Latency to leave start box in cocaine runway0.00.00.00.2-0.1
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.1
Latency to leave start box in cocaine runway, M0.20.10.30.5-0.2
Std. dev. time between licks in bursts0.20.30.4-0.50.6
Total sessions with >9 infusions0.10.20.20.3-0.5
Short access day 1 total inactive lever presses0.10.10.2-0.5-0.3
Short access day 10 total inactive lever presses0.21.12.2-1.50.0
Short access day 1 total infusions0.91.82.01.2-1.4
Short access day 10 total infusions0.30.50.50.7-0.7
Short access total infusions0.81.21.21.1-1.1
Short access day 1 locomotion0.10.10.20.50.2
Short access day 10 total locomotion0.00.10.1-0.2-0.3
Short access total locomotion0.30.50.70.8-0.5
One hour access (0.3 mA shock)1.11.41.4-1.21.2
Compulsive drug intake1.92.93.11.8-1.6
One hour access (shock baseline)1.53.94.5-1.82.1
Social response proportion6.07.68.2-2.62.9
Social responses2.83.64.0-1.82.0
Social time1.42.23.31.8-1.0
Soleus weight1.13.34.0-2.01.6
Bone: stiffness0.81.41.8-1.01.3
Tibialis anterior weight7.726.627.2-5.25.1
Time to tail flick, vehicle, before self-admin0.40.50.80.9-0.3
Time to tail flick, vehicle, after self-admin0.00.10.2-0.10.4
Time to tail flick, test, before self-admin1.41.61.9-1.41.1
Time to tail flick, test, after self-admin0.10.10.20.4-0.2
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.0
Delta time to tail flick, test, before/after SA1.21.51.61.3-1.2
Tibia length3.810.513.9-3.72.7
Ambulatory time before self-admin0.00.10.10.30.2
Ambulatory time after self-admin0.10.20.30.6-0.2
Bone: tissue strength0.10.10.2-0.3-0.4
Total heroin consumption2.32.74.32.1-1.1
Bone: trabecular number2.44.66.2-2.51.7
Bone: trabecular spacing3.04.45.02.2-1.9
Bone: trabecular thickness3.14.45.2-2.31.9
Bone: trabecular tissue density0.61.12.2-0.31.5
Water consumed over 24 hours1.73.34.5-2.11.4
Number of responses in last shaping day0.20.30.30.5-0.5