Hub : Genes

LOC120101608

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC120101608	0.02	0.02	1.7e-03	0.02	0.02	0.02	0.02	1.0e-03	6.8e-04	2.1e-03	1.9e-03
2	LHb	gene expression	LOC120101608	0.14	0.13	7.7e-03	0.06	0.07	0.06	0.06	1.4e-02	9.2e-03	1.6e-02	2.0e-02
3	BLA	gene expression	LOC120101608	0.09	0.08	2.0e-03	0.03	0.03	0.04	0.03	6.3e-03	6.5e-03	5.3e-03	7.9e-03
4	PL	gene expression	LOC120101608	0.07	0.05	4.9e-10	0.07	0.09	0.08	0.08	1.8e-08	7.7e-10	3.0e-09	2.5e-09
5	Brain	gene expression	LOC120101608	0.03	0.02	1.5e-03	0.02	0.01	0.01	0.01	6.6e-03	3.7e-02	4.2e-02	3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.7	1.1	1.1	1.0	1.0	-1.1	1.0	-1.0
Area under the delay curve	0.4	0.5	0.5	-0.6	-0.6	0.7	-0.7	0.7
BMI with tail	0.2	0.5	0.6	0.8	0.8	-0.7	0.6	-0.8
BMI without tail	0.5	1.1	1.4	1.1	1.1	-1.1	0.9	-1.2
Body weight	0.3	1.5	1.9	1.4	1.4	-1.1	1.1	-1.0
Weight adjusted by age	2.1	2.4	2.5	-1.6	-1.6	1.4	-1.6	1.6
Bone surface	0.4	0.6	0.7	0.8	0.9	-0.8	0.7	-0.7
Bone volume	1.5	2.6	2.7	1.6	1.6	-1.6	1.6	-1.6
Breakpoint value in progressive ratio session	1.2	1.3	1.4	-1.2	-1.2	1.1	-1.1	1.1
Number of licking bursts	0.0	0.0	0.1	0.3	0.2	-0.0	0.2	-0.1
Context. condit. distance diff. score	2.0	2.5	3.9	1.6	1.6	-1.3	2.0	-1.3
Locomotion velocity, session 1	0.0	0.0	0.1	-0.0	-0.0	-0.1	-0.0	-0.2
Locomotion distance, session 1	0.1	0.2	0.2	0.3	0.3	-0.4	0.5	-0.4
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.1
Locomotion distance, session 2	0.4	0.5	0.6	0.8	0.7	-0.7	0.7	-0.7
Locomotion velocity, session 3	0.3	0.3	0.5	0.5	0.5	-0.6	0.5	-0.7
Locomotion distance, session 3	0.3	0.4	0.4	0.6	0.6	-0.6	0.6	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.2	0.2	-0.3	0.4	-0.4
Stereotopy head waving duration, day 3	0.6	0.7	0.8	0.7	0.7	-0.8	0.9	-0.9
Locomotion velocity, session 7	0.3	0.4	0.6	0.5	0.5	-0.7	0.6	-0.8
Locomotion distance, session 7	0.2	0.3	0.3	-0.5	-0.5	0.5	-0.4	0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.1	0.1	-0.1	0.3	-0.3
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	-0.2
Locomotion velocity, session 8	0.7	0.9	1.2	0.9	0.9	-0.9	1.1	-0.8
Locomotion distance, session 8	3.0	4.4	5.8	2.1	2.1	-1.9	2.4	-1.9
Degree of sensitization distance	0.6	0.6	0.9	-0.8	-0.8	0.8	-0.6	0.9
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.1	-0.0
Conditioned locomotion	5.0	5.8	6.8	-2.4	-2.4	2.5	-2.2	2.6
Cocaine response after cond. corrected	2.0	2.3	2.4	-1.5	-1.5	1.5	-1.5	1.5
Cocaine response after cond. not corrected	0.5	0.6	0.6	-0.7	-0.7	0.8	-0.8	0.8
Cocaine response before conditioning	4.0	4.8	5.2	2.2	2.2	-2.1	2.3	-2.1
Saline control response	0.8	1.0	1.2	1.0	1.0	-1.0	1.0	-1.1
Bone: connectivity density	0.4	0.7	0.7	0.8	0.8	-0.8	0.8	-0.8
Bone: cortical apparent density	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.3	0.4
Bone: cortical area	0.0	0.0	0.0	0.1	0.1	-0.0	-0.2	0.0
Bone: cortical porosity	0.5	0.6	0.6	-0.8	-0.8	0.8	-0.7	0.7
Bone: cortical porosity	0.4	0.4	0.5	-0.7	-0.6	0.7	-0.6	0.7
Bone: cortical thickness	0.1	0.1	0.4	-0.2	-0.2	0.2	-0.6	0.2
Bone: cortical thickness	5.4	6.3	7.1	-2.4	-2.4	2.5	-2.6	2.7
Bone: cortical tissue density	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.2	0.4
Condit. Reinf. active minus inactive responses	0.9	1.0	1.1	1.0	1.0	-1.0	1.1	-0.9
Condit. Reinf. active-inactive response ratio	1.4	1.5	1.7	1.3	1.3	-1.2	1.2	-1.1
Condit. Reinf. active responses	0.2	0.3	0.3	0.6	0.5	-0.5	0.6	-0.4
Condit. Reinf. inactive responses	0.3	0.3	0.3	-0.6	-0.6	0.6	-0.5	0.5
Incentive salience index mean	0.8	0.9	1.0	1.0	1.0	-1.0	1.0	-0.9
Condit. Reinf. lever presses	0.6	0.8	0.9	1.0	1.0	-0.9	0.8	-0.9
Condit. Reinf. active minus inactive responses	1.2	1.5	2.2	1.2	1.2	-1.2	1.5	-1.1
Condit. Reinf. active-inactive response ratio	3.0	3.1	3.7	1.8	1.7	-1.7	1.9	-1.6
Condit. Reinf. active responses	0.8	1.1	1.4	1.0	1.0	-1.0	1.2	-1.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.1
Condit. Reinf. lever presses	0.6	0.8	0.9	0.8	0.8	-0.9	0.9	-1.0
Condit. Reinf. lever reinforcers received	0.9	1.3	1.7	1.1	1.1	-1.1	1.3	-1.1
Conditioned reinforcement - actives	3.6	3.6	4.0	1.9	1.9	-2.0	1.8	-1.8
Conditioned reinforcement - inactives	8.7	9.8	11.0	3.3	3.3	-3.3	2.8	-3.0
Conditioned locomotion	2.7	3.3	3.8	1.9	1.9	-1.9	1.7	-1.6
Patch foraging indifference point 0 sec	0.2	0.3	0.7	-0.5	-0.5	0.5	-0.4	0.8
Patch foraging indifference point AUC	0.8	0.9	1.2	-1.1	-1.1	0.7	-1.1	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.4	0.3
Delay disc. indifference point, 16s delay	2.2	2.3	2.8	-1.5	-1.5	1.4	-1.7	1.4
Delay disc. indifference point, 2s delay	0.5	0.6	0.8	-0.7	-0.7	0.9	-0.7	0.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.6	-0.6	0.5	-0.4	0.3
Delay disc. indifference point, 4s delay	0.5	0.6	0.9	-0.6	-0.6	0.8	-0.7	0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	-0.3
Indifference point function ln k	0.2	0.3	0.5	0.7	0.7	-0.4	0.5	-0.0
Indifference point function log k	0.2	0.3	0.5	0.7	0.7	-0.4	0.5	-0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.4	-0.4	0.4	-0.3	0.7
Patch foraging total patch changes 12 sec	0.4	0.5	0.7	0.6	0.6	-0.8	0.6	-0.8
Patch foraging total patch changes 18 sec	0.3	0.4	0.6	-0.7	-0.7	0.5	-0.5	0.8
Patch foraging total patch changes 24 sec	0.6	0.8	1.2	-1.1	-1.1	0.8	-0.8	0.6
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.2	0.1
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.2	0.2	-0.2	0.4	-0.3
Patch foraging water rate 0 sec	0.1	0.2	0.5	-0.3	-0.3	0.4	-0.5	0.7
Patch foraging water rate 12 sec	0.6	0.8	1.0	-0.9	-0.9	1.0	-0.9	1.0
Patch foraging water rate 18 sec	0.4	0.5	0.5	0.7	0.7	-0.6	0.7	-0.7
Patch foraging water rate 24 sec	0.5	0.8	0.9	-0.8	-0.8	0.9	-0.9	0.9
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.4	-0.4	0.6	-0.4	0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.3	0.4	0.4	-0.6	0.0	-0.4
Distance traveled before self-admin	0.4	0.4	0.6	0.8	0.8	-0.6	0.5	-0.4
Distance traveled after self-admin	0.4	0.5	0.6	0.7	0.7	-0.8	0.5	-0.6
Extensor digitorum longus weight	0.4	1.6	1.7	-1.2	-1.2	1.3	-1.3	1.3
Bone: elastic displacement	1.8	2.0	2.5	-1.5	-1.5	1.3	-1.6	1.2
Bone: elastic work	1.4	1.8	2.4	-1.4	-1.4	1.2	-1.6	1.1
Bone: endosteal estimation	0.4	0.8	1.0	-0.8	-0.8	1.0	-0.8	1.0
Bone: endosteal perimeter	0.2	0.3	0.4	0.6	0.6	-0.5	0.7	-0.5
Epididymis fat weight	0.8	1.8	2.1	1.3	1.3	-1.3	1.3	-1.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.2	0.2	0.1	-0.0	0.4	0.1
Delta time in open arm before/after self-admin	0.7	0.7	1.1	-0.7	-0.7	0.9	-1.0	0.9
Diff in mean of infusions in LGA sessions	0.6	0.7	1.1	-0.6	-0.6	0.7	-1.0	1.0
Delay discount exponential model param	0.5	0.6	0.6	0.7	0.7	-0.8	0.7	-0.8
Extinction: sum of active levers before priming	0.6	0.6	0.8	0.7	0.7	-0.6	0.9	-0.8
Active lever presses in extinction session 6	0.8	0.8	1.2	0.7	0.7	-0.7	1.1	-1.1
Bone: final force	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	0.0
Bone: final moment	0.1	0.2	0.3	-0.4	-0.4	0.4	-0.5	0.3
Food consumed during 24 hour testing period	6.7	8.1	8.4	2.9	2.9	-2.9	2.7	-2.8
Glucose	2.3	3.5	3.8	1.8	1.8	-1.8	2.0	-1.8
Heart weight	0.5	0.7	1.0	-1.0	-1.0	0.9	-0.7	0.4
Delay discount hyperbolic model param	0.4	0.5	0.5	0.6	0.6	-0.7	0.7	-0.7
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.2	0.2	-0.3	0.2	-0.2
Intermittent access intake escalation	0.3	0.3	0.3	0.5	0.5	-0.5	0.5	-0.5
Intermittent access intake escalation 2	1.8	1.8	2.1	1.5	1.5	-1.4	1.2	-1.2
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.3	-0.3	0.4	-0.4	0.6
Intermitt. access day 15 inactive lever presses	2.8	3.0	3.7	1.9	1.9	-1.9	1.4	-1.5
Intermitt. access escalation Index	0.0	0.0	0.1	0.1	0.1	-0.2	0.2	-0.2
Intermittent access day 1 total infusions	3.8	4.3	4.7	2.2	2.2	-2.0	2.1	-1.9
Intermittent access day 15 total infusions	4.5	5.1	5.6	2.4	2.4	-2.2	2.2	-2.1
Intermittent access terminal intake (last 3 days)	5.7	6.2	7.0	2.6	2.6	-2.5	2.4	-2.3
Intermittent access total infusions	5.3	5.9	7.0	2.6	2.6	-2.4	2.3	-2.1
Intermittent access day 1 locomotion	1.6	1.7	1.9	1.4	1.4	-1.2	1.4	-1.1
Intermittent access day 15 total locomotion	2.8	3.0	3.2	1.7	1.7	-1.7	1.8	-1.7
Intermittent access total locomotion	2.6	3.0	3.4	1.9	1.9	-1.7	1.6	-1.5
Intermittent access standard deviation	5.7	6.0	7.0	2.6	2.6	-2.4	2.4	-2.1
Left kidney weight	0.5	1.3	1.5	1.2	1.2	-1.0	1.1	-1.1
Right kidney weight	0.6	1.7	2.4	1.3	1.3	-1.2	1.2	-1.6
Cocaine induced anxiety	0.1	0.1	0.2	0.4	0.4	-0.3	0.1	-0.1
Post-drug Anxiety	0.0	0.0	0.2	-0.0	-0.0	-0.0	-0.4	0.2
Baseline Anxiety	2.2	2.3	2.7	-1.6	-1.5	1.4	-1.6	1.4
Tail length	0.3	1.0	1.4	1.0	1.0	-0.9	0.9	-1.2
Length with tail	0.1	0.4	0.6	0.8	0.8	-0.5	0.6	-0.4
Length without tail	0.0	0.1	0.1	0.4	0.4	-0.1	0.3	0.1
Times rat made contact with spout	0.1	0.1	0.2	0.4	0.4	-0.5	0.3	-0.4
Lifetime Intake	5.4	6.2	7.3	2.7	2.7	-2.5	2.3	-2.2
Liver weight, left	0.2	0.3	0.4	0.5	0.5	-0.6	0.7	-0.7
Liver weight, right	0.8	1.4	1.7	1.3	1.3	-1.1	1.2	-1.0
Locomotor activity	0.1	0.1	0.4	0.1	0.1	-0.2	0.4	-0.6
Locomotor testing distance	1.2	2.1	3.1	1.3	1.3	-1.3	1.5	-1.8
Locomotor testing rearing	0.2	0.3	0.6	0.3	0.3	-0.3	0.7	-0.7
Locomotion in novel chamber	0.5	0.6	0.8	0.9	0.9	-0.8	0.7	-0.6
Locomotion in novel chamber post-restriction	1.3	1.6	2.0	-1.3	-1.3	1.4	-1.2	1.0
Fecal boli incidents, locomotor time 1	10.1	11.0	11.5	-3.4	-3.4	3.4	-3.2	3.4
Change in fecal boli incidents, locomotor task	8.1	7.6	8.1	2.8	2.8	-2.7	2.8	-2.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.0	0.0
Bouts of movement, locomotor time 1	1.9	2.1	2.6	-1.2	-1.2	1.5	-1.5	1.6
Total resting periods, locomotor time 1	1.6	1.8	2.3	-1.2	-1.2	1.4	-1.4	1.5
Rest time, locomotor task time 1	1.0	1.1	1.5	-0.9	-0.9	1.2	-0.9	1.2
Distance moved, locomotor task time 1	2.2	2.4	2.8	1.7	1.7	-1.7	1.3	-1.4
Vertical activity count, locomotor time 1	0.2	0.2	0.3	0.4	0.4	-0.5	0.3	-0.4
Time >=10cm from walls, locomotor time 2	6.1	6.5	6.9	2.5	2.5	-2.5	2.6	-2.6
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.3	-0.3	0.3	-0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	-0.2	0.2	0.0	-0.1
Rest time, locomotor task time 2	1.9	2.2	3.3	-1.5	-1.6	1.8	-1.0	1.4
Distance moved, locomotor task time 2	3.2	3.7	4.6	2.1	2.2	-2.1	1.3	-1.7
Vertical activity count, locomotor time 2	2.2	2.4	3.0	1.7	1.7	-1.7	1.1	-1.5
Light reinforcement 1	0.2	0.4	0.5	0.7	0.7	-0.7	0.5	-0.7
Light reinforcement 2	0.0	0.0	0.1	0.1	0.1	0.0	-0.2	0.3
Bone: marrow area	0.3	0.7	0.9	-0.8	-0.8	1.0	-0.8	0.9
Bone: maximum diameter	0.0	0.0	0.1	0.3	0.3	-0.2	0.1	-0.1
Bone: maximum force	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.0
Bone: maximum moment	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.4	0.3
Mean time between licks in bursts	1.1	1.5	1.9	-1.2	-1.3	1.4	-1.0	1.3
Mean num. licks in bursts	0.1	0.1	0.2	0.2	0.2	-0.4	0.2	-0.3
Cd content in liver	2.2	2.4	2.7	1.5	1.5	-1.6	1.5	-1.6
Co content in liver	1.6	1.9	2.2	-1.4	-1.4	1.3	-1.5	1.4
Cu content in liver	0.9	1.2	1.4	-1.0	-1.0	1.1	-1.2	1.1
Fe content in liver	0.7	0.9	1.1	-1.0	-1.0	1.0	-0.8	0.9
K content in liver	2.0	2.0	2.7	-1.3	-1.3	1.3	-1.7	1.4
Mg content in liver	2.5	2.6	3.3	-1.5	-1.5	1.6	-1.8	1.6
Mn content in liver	1.8	2.0	2.2	-1.4	-1.4	1.5	-1.3	1.5
Na content in liver	0.2	0.2	0.3	-0.4	-0.4	0.5	-0.5	0.5
Rb content in liver	1.1	1.3	1.8	-1.2	-1.2	1.0	-1.3	0.9
Se content in liver	4.6	5.7	5.9	-2.4	-2.4	2.4	-2.4	2.4
Sr content in liver	0.6	0.6	1.1	-0.6	-0.6	0.8	-0.7	1.0
Zn content in liver	0.2	0.2	0.3	-0.4	-0.4	0.4	-0.5	0.5
Bone: minimum diameter	0.2	0.3	0.5	0.7	0.7	-0.5	0.4	-0.5
Time in familiar zone, hab. session 1	0.4	0.3	0.4	-0.7	-0.7	0.6	-0.5	0.5
Time in novel zone, hab. session 1	0.6	0.6	0.7	0.8	0.8	-0.8	0.6	-0.8
Total zone transitions, hab. session 1	2.7	3.8	4.3	1.9	1.9	-1.9	2.1	-2.0
Total locomotion distance, hab. session 1	1.1	1.6	2.2	1.2	1.2	-1.2	1.5	-1.1
Locomotion velocity, hab. session 1	0.8	1.1	1.6	1.0	1.0	-1.0	1.3	-1.0
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	-0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	0.1
Total zone transitions, hab. session 2	2.3	2.9	3.0	1.7	1.7	-1.7	1.7	-1.7
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	0.3	-0.2	0.5	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	0.2	-0.1	0.4	-0.1
Novel to familiar place preference ratio	1.1	1.1	1.2	1.1	1.1	-1.1	1.0	-1.1
Novelty place preference	1.0	1.0	1.1	1.0	1.0	-1.0	1.0	-1.0
Time in novel zone, NPP test	0.7	0.7	0.8	0.8	0.8	-0.9	0.8	-0.9
Total zone transitions, NPP test	0.3	0.4	0.6	-0.7	-0.7	0.6	-0.5	0.5
Total locomotion distance, NPP test	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.3	0.7
Locomotion velocity, NPP test	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.2	0.5
Intraocular pressure	0.0	0.1	0.1	0.2	0.2	-0.2	0.3	-0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.5	-0.5	0.2	-0.3	0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3	0.4
Parametrial fat weight	1.4	2.7	4.3	1.4	1.5	-1.7	1.4	-2.1
Pavlov. Cond. lever latency	0.6	0.8	0.8	-0.9	-0.9	0.9	-0.8	0.8
Pavlov. Cond. magazine entry latency	1.3	1.7	1.9	1.3	1.3	-1.3	1.4	-1.3
Pavlov. Cond. change in total contacts	0.1	0.2	0.2	-0.3	-0.3	0.4	-0.5	0.5
Pavlov. Cond. index score	0.5	0.7	0.7	0.8	0.8	-0.9	0.8	-0.8
Pavlov. Cond. latency score	0.6	0.8	0.8	0.9	0.9	-0.9	0.8	-0.9
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.6	0.6	-0.6	0.5	-0.5
Pavlov. Cond. magazine entry number	1.4	1.7	1.8	-1.3	-1.3	1.3	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.6	0.7	0.7	-0.8	0.7	-0.8
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	1.1	-1.1	1.1	-1.1
Pavlov. Cond. lever latency	2.5	3.4	3.8	-1.8	-1.8	1.9	-2.0	1.8
Pavlov. Cond. magazine entry latency	1.1	1.3	1.4	1.2	1.1	-1.2	1.1	-1.1
Pavlov. Cond. change in total contacts	1.0	1.4	1.6	1.1	1.1	-1.2	1.1	-1.3
Pavlov. Cond. index score	2.1	2.7	2.8	1.6	1.6	-1.7	1.7	-1.7
Pavlov. Cond. latency score	2.7	3.3	3.5	1.8	1.8	-1.9	1.8	-1.8
Pavlov. Cond. lever contacts	2.6	3.5	3.7	1.8	1.8	-1.9	1.9	-1.9
Pavlov. Cond. magazine entry number	0.7	0.8	0.9	-0.9	-0.9	0.9	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.2	1.5	1.5	-1.5	1.5	-1.5
Pavlov. Cond. response bias	2.0	2.8	3.1	1.6	1.6	-1.7	1.8	-1.7
Time in closed arm before self-admin	0.6	0.6	0.7	0.9	0.9	-0.7	0.7	-0.8
Time in closed arm after self-admin	0.3	0.3	0.5	0.6	0.6	-0.5	0.7	-0.4
Time in open arm before self-admin	0.5	0.6	0.9	-0.9	-0.9	0.8	-0.4	0.5
Time in open arm after self-admin	1.4	1.5	1.7	-1.3	-1.3	1.2	-1.3	1.1
Bone: periosteal estimation	0.2	0.3	0.4	-0.5	-0.5	0.6	-0.7	0.6
Bone: periosteal perimeter	0.8	1.4	1.5	1.2	1.2	-1.2	1.0	-1.1
Bone: post-yield work	0.0	0.1	0.2	-0.1	-0.2	0.3	-0.0	0.4
Progressive ratio test 1 active lever presses	3.6	3.7	4.3	2.1	2.1	-1.9	1.8	-1.7
Progressive ratio test 1 breakpoint	3.2	3.3	3.8	1.9	1.9	-1.9	1.7	-1.6
Progressive ratio test 1 inactive lever presses	2.1	2.3	2.5	1.6	1.6	-1.5	1.5	-1.4
Progressive ratio test 2 active lever presses	2.7	2.9	3.6	1.9	1.9	-1.8	1.4	-1.5
Progressive ratio test 2 breakpoint	3.2	3.6	4.3	2.1	2.1	-2.0	1.6	-1.7
Progressive ratio test 2 inactive lever presses	3.1	3.6	4.6	2.1	2.1	-2.0	1.5	-1.6
Incentive Sensitization - Responses	1.4	1.5	2.0	1.3	1.3	-1.4	0.8	-1.1
Incentive Sensitization - Breakpoint	1.2	1.3	1.7	1.2	1.2	-1.3	0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	-0.6	-0.6	0.6	-0.7	0.6
Progressive ratio	0.4	0.5	0.6	0.8	0.8	-0.8	0.6	-0.5
Food seeking constrained by brief footshock	1.2	1.5	1.9	1.3	1.3	-1.4	1.1	-1.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.2	-0.5	-0.5	0.5	-0.4	0.3
Retroperitoneal fat weight	8.4	27.7	29.0	5.3	5.3	-5.3	5.1	-5.4
Reaction time number correct	0.1	0.1	0.4	-0.0	0.0	-0.3	-0.1	-0.7
Reaction time mean minus median	0.8	1.1	1.5	0.9	0.9	-1.1	0.9	-1.2
Reaction time mean minus median AUC	0.6	0.7	1.3	0.7	0.7	-0.9	0.7	-1.1
Reaction time num false alarms	1.3	1.8	2.2	-1.4	-1.4	1.5	-1.3	1.2
Reaction time num false alarms AUC	2.2	3.0	3.5	-1.8	-1.8	1.9	-1.6	1.5
Reaction time trials correct on left	0.1	0.1	0.4	-0.0	0.0	-0.3	-0.1	-0.7
Reaction time trials on left	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.2	-0.6
Reaction time mean	0.2	0.3	0.4	0.6	0.6	-0.5	0.5	-0.4
Reaction time mean AUC	0.3	0.3	0.5	0.7	0.7	-0.5	0.6	-0.4
Median of all reaction times	0.3	0.4	0.6	0.7	0.7	-0.5	0.7	-0.3
Reaction time omissions	0.6	0.8	0.9	-1.0	-1.0	0.9	-0.8	0.7
Reaction time false alarm rate	2.7	3.8	4.5	-1.9	-1.9	2.1	-1.8	2.0
Reaction time premature initiation rate	0.1	0.1	0.3	-0.5	-0.5	0.3	-0.2	0.2
Reaction time premature initiations	0.1	0.1	0.2	-0.4	-0.4	0.0	-0.2	-0.2
Std. dev. reaction times	0.1	0.1	0.1	0.3	0.3	-0.3	0.2	-0.3
Reaction time trials completed	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.2	-0.6
Reaction time trials AUC	0.1	0.2	0.6	0.1	0.1	-0.4	0.0	-0.8
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.2	0.2	-0.0	0.3	0.2
Run reversals in cocaine runway, males	3.5	3.4	4.0	-2.0	-2.0	1.9	-1.9	1.4
Latency to leave start box in cocaine runway	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.1	0.1	-0.1	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.5	0.4	0.6	-0.6	-0.6	0.7	-0.8	0.7
Std. dev. time between licks in bursts	0.7	0.8	1.0	-1.0	-1.0	1.0	-0.8	0.7
Total sessions with >9 infusions	1.5	1.6	2.0	1.4	1.4	-1.2	1.3	-1.1
Short access day 1 total inactive lever presses	0.8	0.9	1.1	0.9	0.9	-0.9	1.0	-0.9
Short access day 10 total inactive lever presses	0.2	0.2	0.3	0.4	0.5	-0.6	0.2	-0.4
Short access day 1 total infusions	6.5	6.9	8.0	2.8	2.8	-2.6	2.5	-2.4
Short access day 10 total infusions	3.0	3.4	3.9	2.0	2.0	-1.8	1.7	-1.6
Short access total infusions	3.9	4.4	5.1	2.3	2.3	-2.0	2.1	-1.9
Short access day 1 locomotion	2.7	2.8	3.7	1.7	1.7	-1.5	1.9	-1.5
Short access day 10 total locomotion	3.6	4.0	4.6	2.1	2.1	-2.0	2.0	-1.8
Short access total locomotion	2.8	2.9	3.4	1.8	1.8	-1.6	1.8	-1.5
One hour access (0.3 mA shock)	4.1	4.8	5.5	2.3	2.3	-2.3	2.0	-2.0
Compulsive drug intake	0.9	0.9	1.2	-1.1	-1.1	0.9	-0.9	0.8
One hour access (shock baseline)	5.9	6.9	7.8	2.8	2.8	-2.7	2.4	-2.4
Social response proportion	4.4	4.8	5.0	-2.2	-2.2	2.2	-2.1	2.2
Social responses	0.1	0.2	0.4	0.3	0.3	-0.3	0.4	-0.6
Social time	1.5	2.0	2.5	-1.6	-1.6	1.3	-1.6	1.0
Soleus weight	1.6	4.7	5.2	-2.1	-2.1	2.2	-2.0	2.3
Bone: stiffness	0.2	0.4	0.5	0.7	0.7	-0.5	0.7	-0.4
Tibialis anterior weight	3.4	11.6	11.9	-3.4	-3.4	3.4	-3.4	3.4
Time to tail flick, vehicle, before self-admin	5.2	5.3	5.8	2.4	2.4	-2.4	1.9	-2.4
Time to tail flick, vehicle, after self-admin	5.0	5.3	5.7	2.4	2.4	-2.3	2.1	-2.3
Time to tail flick, test, before self-admin	0.7	0.6	0.8	0.9	0.9	-0.9	0.6	-0.7
Time to tail flick, test, after self-admin	2.0	2.0	2.4	1.5	1.5	-1.6	1.2	-1.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.3	0.3	-0.4	0.5	-0.5
Tibia length	0.2	0.6	0.9	-0.8	-0.8	0.7	-0.9	0.7
Ambulatory time before self-admin	0.1	0.1	0.2	0.5	0.5	-0.3	0.2	-0.2
Ambulatory time after self-admin	0.3	0.3	0.4	0.6	0.6	-0.6	0.4	-0.4
Bone: tissue strength	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1	-0.0
Total heroin consumption	0.9	1.1	1.5	-1.0	-1.0	1.2	-0.9	1.1
Bone: trabecular number	0.3	0.5	0.6	0.8	0.8	-0.7	0.7	-0.6
Bone: trabecular spacing	0.5	0.6	0.9	0.7	0.7	-0.8	0.7	-1.0
Bone: trabecular thickness	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	-0.4
Bone: trabecular tissue density	1.1	1.5	1.7	-1.2	-1.2	1.3	-1.3	1.3
Water consumed over 24 hours	0.0	0.0	0.0	0.2	0.2	-0.1	-0.0	-0.2
Number of responses in last shaping day	0.9	0.9	1.2	1.1	1.1	-1.1	0.7	-0.8