LOC120099895

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC120099895	0.14	0.1	3.2e-05	0.07	0.09	0.1	0.08	8.0e-05	2.4e-05	3.9e-06	4.7e-05
2	Adipose	gene expression	LOC120099895	0.03	0.03	2.0e-03	0.02	0.02	0.01	0.02	1.8e-03	3.5e-03	1.3e-02	3.1e-03
3	NAcc	gene expression	LOC120099895	0.08	0.05	2.3e-09	0.06	0.08	0.06	0.07	7.0e-08	2.8e-09	7.3e-08	3.7e-08
4	PL	gene expression	LOC120099895	0.11	0.06	7.8e-14	0.12	0.13	0.12	0.13	6.7e-13	2.8e-14	1.3e-13	2.3e-14
5	Liver	gene expression	LOC120099895	0.14	0.08	2.8e-13	0.1	0.1	0.08	0.1	7.3e-11	3.8e-11	5.6e-09	4.9e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.2	-0.2	0.4	0.1	0.4	0.4
Area under the delay curve	0.2	0.3	0.7	0.8	0.2	-0.5	-0.4	-0.4
BMI with tail	0.2	0.5	1.9	1.4	-0.2	-0.4	-0.5	-0.4
BMI without tail	0.7	1.4	2.0	1.1	-1.4	-0.8	-1.3	-1.3
Body weight	0.5	2.2	3.5	1.1	-1.3	-1.2	-1.7	-1.9
Weight adjusted by age	0.2	0.3	1.0	0.2	-1.0	-0.1	-0.4	-0.4
Bone surface	0.6	1.1	1.6	-1.1	-1.3	1.0	1.0	0.9
Bone volume	0.4	0.7	0.9	-0.9	-0.9	0.8	0.9	0.7
Breakpoint value in progressive ratio session	0.1	0.2	0.6	-0.3	0.8	0.0	0.2	0.3
Number of licking bursts	5.7	6.7	7.9	2.7	2.4	-2.8	-2.5	-2.5
Context. condit. distance diff. score	3.4	4.1	5.1	-2.3	-1.5	2.1	2.2	2.0
Locomotion velocity, session 1	0.2	0.2	0.5	-0.0	0.7	0.2	0.5	0.6
Locomotion distance, session 1	1.3	1.7	2.4	-1.6	-0.8	1.3	1.3	1.4
Locomotion velocity, session 2	0.1	0.1	0.3	-0.6	-0.3	0.2	0.1	0.1
Locomotion distance, session 2	0.5	0.7	1.0	-1.0	-0.7	0.9	0.8	0.8
Locomotion velocity, session 3	1.4	1.6	2.6	-1.6	-0.4	1.2	1.4	1.3
Locomotion distance, session 3	2.3	2.5	3.3	-1.7	-0.7	1.6	1.8	1.8
Stereotopy head waving bouts, day 3	0.6	0.7	1.2	0.4	0.4	-1.0	-1.0	-1.1
Stereotopy head waving duration, day 3	0.2	0.2	0.6	-0.8	-0.1	0.4	0.4	0.4
Locomotion velocity, session 7	0.1	0.1	0.5	0.2	0.7	-0.2	0.1	0.0
Locomotion distance, session 7	0.2	0.3	0.9	0.9	0.4	-0.4	-0.3	-0.5
Stereotopy head waving bouts, day 7	3.8	4.2	7.9	-2.8	-1.6	1.9	1.9	1.9
Stereotopy head waving duration, day 7	3.7	4.5	7.8	-2.8	-1.9	2.0	1.8	1.9
Locomotion velocity, session 8	1.2	1.4	3.1	-1.7	-0.8	1.1	1.1	1.0
Locomotion distance, session 8	2.8	4.1	5.7	-2.4	-1.8	2.1	2.0	1.8
Degree of sensitization distance	2.6	2.6	4.0	1.7	0.2	-1.6	-1.8	-2.0
Degree of sensitization stereotypy	7.3	8.0	12.7	-3.6	-2.4	2.8	2.6	2.6
Conditioned locomotion	0.1	0.1	0.2	0.2	0.4	0.1	0.3	0.1
Cocaine response after cond. corrected	2.7	3.0	3.8	2.0	1.2	-1.8	-1.8	-1.8
Cocaine response after cond. not corrected	0.7	0.8	1.4	1.2	0.7	-0.9	-0.9	-0.8
Cocaine response before conditioning	2.9	3.5	4.5	-1.9	-1.2	2.0	2.0	2.1
Saline control response	1.3	1.7	3.8	-1.7	-2.0	1.1	0.7	0.6
Bone: connectivity density	0.3	0.4	0.9	-0.4	0.1	0.6	0.8	0.9
Bone: cortical apparent density	2.6	3.4	4.0	1.9	1.4	-2.0	-1.8	-2.0
Bone: cortical area	0.2	0.3	0.8	-0.5	-0.9	0.3	0.3	-0.1
Bone: cortical porosity	1.6	1.7	2.3	-1.2	-0.7	1.5	1.5	1.5
Bone: cortical porosity	1.4	1.5	2.0	-1.2	-0.6	1.4	1.4	1.4
Bone: cortical thickness	0.1	0.1	0.3	0.1	0.5	-0.3	-0.0	-0.3
Bone: cortical thickness	0.3	0.3	0.7	-0.5	-0.3	0.6	0.8	0.5
Bone: cortical tissue density	2.5	3.3	3.9	2.0	1.4	-1.9	-1.8	-1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.1	-0.6	-0.1	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.0	-0.2	-1.0	0.1	-0.2	-0.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.0	-0.2	-0.2	-0.4	-0.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1	-0.0
Incentive salience index mean	0.1	0.1	0.4	-0.2	-0.7	0.0	-0.2	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	-0.4	0.1	0.0	0.1
Condit. Reinf. active minus inactive responses	4.8	6.0	12.8	-2.9	-3.6	2.2	1.5	1.4
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.6	-1.5	-1.6	1.2	0.9	1.0
Condit. Reinf. active responses	5.6	7.7	18.4	-3.2	-4.3	2.4	1.5	1.4
Condit. Reinf. inactive responses	2.8	3.5	9.4	-2.1	-3.1	1.5	0.9	0.7
Condit. Reinf. lever presses	13.4	18.2	31.6	-4.6	-5.6	4.2	3.3	3.1
Condit. Reinf. lever reinforcers received	6.8	9.5	20.6	-3.6	-4.5	2.7	1.8	1.7
Conditioned reinforcement - actives	3.5	3.5	4.4	-1.6	-1.5	2.1	2.1	2.0
Conditioned reinforcement - inactives	0.2	0.3	0.4	0.6	0.1	-0.5	-0.6	-0.6
Conditioned locomotion	4.2	5.0	6.2	-2.3	-1.5	2.4	2.5	2.4
Patch foraging indifference point 0 sec	3.2	5.1	7.0	-1.8	-2.6	2.5	2.2	2.1
Patch foraging indifference point AUC	0.4	0.5	0.9	0.2	-0.5	-0.6	-0.9	-0.9
Delay disc. indifference point, 0s delay	0.4	0.5	0.9	-0.7	-1.0	0.6	0.5	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.6	0.7	0.4	-0.1	0.0	-0.0
Delay disc. indifference point, 2s delay	0.2	0.3	1.0	-0.4	-1.0	0.1	-0.1	-0.1
Delay disc. indifference point, 24s delay	1.1	1.1	2.2	1.5	1.2	-0.9	-0.7	-0.7
Delay disc. indifference point, 4s delay	0.3	0.3	1.2	-0.4	-1.1	-0.1	-0.3	-0.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	0.5	0.1	-0.1	0.0	-0.0
Indifference point function ln k	2.2	3.1	4.8	-1.5	-0.7	2.0	2.2	2.1
Indifference point function log k	2.2	3.1	4.8	-1.5	-0.7	2.0	2.2	2.1
Patch foraging total patch changes 0 sec	2.4	3.9	5.6	-1.5	-2.4	2.2	1.9	1.8
Patch foraging total patch changes 12 sec	0.4	0.5	2.5	-0.3	-1.6	0.3	-0.1	-0.2
Patch foraging total patch changes 18 sec	1.3	1.6	4.3	-0.8	-2.1	1.3	0.8	0.9
Patch foraging total patch changes 24 sec	0.5	0.6	2.5	-0.3	-1.6	0.4	-0.1	-0.1
Patch foraging total patch changes 6 sec	0.4	0.6	0.8	-0.6	-0.9	0.9	0.8	0.8
Patch foraging time to switch 0 sec	2.5	3.8	6.3	2.1	2.5	-2.0	-1.6	-1.5
Patch foraging water rate 0 sec	2.7	4.3	5.1	-2.0	-2.3	2.2	2.0	1.9
Patch foraging water rate 12 sec	2.3	3.6	4.5	-1.7	-1.7	2.1	2.0	1.9
Patch foraging water rate 18 sec	1.0	1.4	2.5	-1.6	-1.4	1.1	0.9	0.7
Patch foraging water rate 24 sec	1.8	2.5	3.7	-1.3	-0.6	1.8	1.9	1.8
Patch foraging water rate 6 sec	1.4	2.1	2.6	-1.5	-1.0	1.6	1.5	1.5
Seeking ratio, delayed vs. immediate footshock	0.5	0.5	1.7	0.6	1.3	-0.6	-0.5	-0.2
Distance traveled before self-admin	1.7	1.8	2.6	1.6	1.2	-1.4	-1.1	-1.2
Distance traveled after self-admin	0.5	0.6	1.2	-1.1	0.9	0.3	0.6	0.6
Extensor digitorum longus weight	0.4	1.7	2.7	1.6	0.0	-1.3	-1.4	-1.5
Bone: elastic displacement	1.1	1.2	3.8	0.7	2.0	-1.1	-0.7	-0.5
Bone: elastic work	0.9	1.2	4.0	1.0	2.0	-0.8	-0.4	-0.2
Bone: endosteal estimation	0.4	1.0	4.3	-0.4	-2.1	0.6	0.1	-0.0
Bone: endosteal perimeter	0.7	1.5	5.2	-1.0	-2.3	0.9	0.5	0.3
Epididymis fat weight	1.6	3.7	5.9	2.4	0.4	-1.9	-2.2	-2.1
Delta time in closed arm before/after self-admin	5.2	5.0	8.0	2.8	0.4	-2.2	-2.4	-2.5
Delta time in open arm before/after self-admin	3.4	3.2	4.4	-1.9	-2.1	1.9	1.5	1.5
Diff in mean of infusions in LGA sessions	3.0	3.3	4.5	0.9	1.9	-2.1	-1.9	-1.9
Delay discount exponential model param	0.3	0.3	0.8	-0.9	-0.3	0.5	0.5	0.5
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.3
Active lever presses in extinction session 6	5.0	4.8	6.7	-2.4	-0.7	2.3	2.6	2.4
Bone: final force	0.0	0.1	0.3	0.5	0.1	-0.2	-0.0	-0.3
Bone: final moment	0.0	0.0	0.1	0.3	-0.2	0.0	0.1	-0.2
Food consumed during 24 hour testing period	4.7	5.7	7.5	-2.7	-2.0	2.4	2.3	2.3
Glucose	0.1	0.2	0.4	-0.6	0.0	0.3	0.5	0.5
Heart weight	1.2	1.7	2.0	-1.4	-1.4	1.4	1.1	1.2
Delay discount hyperbolic model param	0.2	0.2	0.6	-0.7	0.0	0.4	0.5	0.5
Intermittent access intake day 1-15 change	0.9	0.9	1.6	-1.3	-0.8	0.8	0.9	0.8
Intermittent access intake escalation	1.0	1.0	1.8	-1.3	-0.8	0.9	1.0	0.9
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	-0.5	-0.0	0.0	-0.2
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.8	1.4	0.5	-0.7	-0.9	-0.8
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.7	-1.3	-0.3	0.7	0.6	0.8
Intermitt. access escalation Index	0.2	0.2	0.4	-0.0	-0.6	0.5	0.5	0.4
Intermittent access day 1 total infusions	1.3	1.5	2.3	-1.5	-1.5	1.2	0.8	1.0
Intermittent access day 15 total infusions	2.3	2.6	4.0	-2.0	-1.6	1.6	1.4	1.4
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.7	-1.7	-1.5	1.3	1.1	1.1
Intermittent access total infusions	1.3	1.4	2.1	-1.4	-1.4	1.2	0.8	0.9
Intermittent access day 1 locomotion	0.5	0.5	1.1	-1.0	-0.3	0.6	0.6	0.7
Intermittent access day 15 total locomotion	2.0	2.1	3.1	-1.8	-1.2	1.4	1.4	1.4
Intermittent access total locomotion	1.1	1.2	2.3	-1.5	-1.0	1.0	0.9	1.0
Intermittent access standard deviation	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	-0.1
Left kidney weight	0.3	0.8	3.3	0.3	-1.8	-0.1	-0.6	-0.6
Right kidney weight	0.2	0.6	1.8	0.6	-1.4	-0.2	-0.6	-0.7
Cocaine induced anxiety	2.1	2.4	3.6	1.9	1.7	-1.5	-1.2	-1.2
Post-drug Anxiety	1.2	1.4	1.8	0.9	1.0	-1.3	-1.2	-1.3
Baseline Anxiety	0.9	0.9	1.9	-1.4	-1.3	0.8	0.5	0.4
Tail length	1.0	3.2	9.5	-0.7	-3.1	-0.6	-1.5	-1.8
Length with tail	0.7	2.6	4.3	-0.3	-2.1	-1.0	-1.8	-2.1
Length without tail	0.1	0.2	0.4	-0.0	0.6	-0.5	-0.5	-0.5
Times rat made contact with spout	0.7	0.9	1.3	0.7	0.3	-1.1	-1.1	-1.2
Lifetime Intake	1.7	1.9	2.9	-1.7	-1.6	1.4	1.0	1.1
Liver weight, left	2.0	3.2	5.7	2.4	0.4	-1.7	-1.9	-2.0
Liver weight, right	3.9	6.5	9.1	2.8	0.6	-2.6	-2.9	-3.0
Locomotor activity	0.5	0.7	0.9	-0.9	-0.7	0.9	0.9	0.8
Locomotor testing distance	1.2	2.1	3.5	-1.6	-1.9	1.4	1.1	1.0
Locomotor testing rearing	0.3	0.5	1.6	-0.7	-1.3	0.0	-0.3	-0.4
Locomotion in novel chamber	1.1	1.4	3.0	-0.1	-0.2	1.3	1.7	1.5
Locomotion in novel chamber post-restriction	3.2	3.9	5.0	-2.2	-1.5	2.0	2.0	2.0
Fecal boli incidents, locomotor time 1	1.2	1.4	2.2	0.4	-0.6	1.4	1.5	1.4
Change in fecal boli incidents, locomotor task	1.0	1.0	1.2	0.7	0.9	-1.1	-1.1	-1.1
Time >=10cm from walls, locomotor time 1	2.1	2.2	3.0	-1.0	-1.2	1.7	1.7	1.6
Bouts of movement, locomotor time 1	0.3	0.3	0.5	-0.7	-0.4	0.6	0.6	0.5
Total resting periods, locomotor time 1	0.4	0.5	0.6	-0.7	-0.1	0.7	0.8	0.8
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.6	0.3	0.4	0.6	0.5
Distance moved, locomotor task time 1	0.4	0.5	0.7	0.6	-0.6	-0.6	-0.8	-0.8
Vertical activity count, locomotor time 1	0.2	0.2	0.6	0.1	-0.8	-0.1	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	1.3	1.3	2.2	-1.3	-1.5	1.2	0.9	0.7
Bouts of movement, locomotor time 2	0.4	0.5	0.7	0.8	-0.8	-0.3	-0.6	-0.8
Total resting periods, locomotor time 2	0.6	0.6	1.0	1.0	-0.4	-0.6	-0.8	-1.0
Rest time, locomotor task time 2	2.1	2.4	4.3	1.4	2.1	-1.6	-1.4	-1.2
Distance moved, locomotor task time 2	2.1	2.4	5.0	-1.7	-2.2	1.5	1.1	1.0
Vertical activity count, locomotor time 2	0.5	0.5	2.2	-0.3	-1.5	0.5	0.2	0.1
Light reinforcement 1	2.6	4.7	6.2	2.5	2.5	-2.1	-2.0	-1.7
Light reinforcement 2	0.2	0.2	1.0	0.1	1.0	-0.2	0.0	0.2
Bone: marrow area	0.3	0.8	3.5	-0.2	-1.9	0.4	-0.0	-0.2
Bone: maximum diameter	1.0	1.8	4.6	-1.5	-2.1	1.1	0.8	0.5
Bone: maximum force	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	-0.1
Bone: maximum moment	0.1	0.1	0.2	-0.2	-0.5	0.3	0.4	0.1
Mean time between licks in bursts	1.8	2.5	10.4	-1.0	-3.2	1.1	0.4	0.1
Mean num. licks in bursts	4.4	5.3	6.1	-2.5	-2.2	2.4	2.2	2.1
Cd content in liver	1.1	1.2	1.6	1.2	0.3	-1.2	-1.3	-1.2
Co content in liver	0.8	0.9	2.8	-1.1	-1.7	0.6	0.3	0.1
Cu content in liver	0.3	0.4	1.8	-0.4	-1.3	0.2	-0.1	-0.2
Fe content in liver	0.1	0.1	0.1	0.0	0.1	-0.3	-0.3	-0.3
K content in liver	0.5	0.5	0.7	0.7	0.3	-0.7	-0.7	-0.8
Mg content in liver	0.1	0.1	0.2	-0.3	-0.4	0.2	0.1	0.1
Mn content in liver	0.7	0.7	2.9	0.8	1.7	-0.5	-0.1	0.0
Na content in liver	0.5	0.6	1.3	-1.1	-0.4	0.6	0.7	0.7
Rb content in liver	0.6	0.7	1.3	-1.1	-1.1	0.7	0.5	0.5
Se content in liver	2.3	2.8	5.6	1.6	2.4	-1.7	-1.3	-1.2
Sr content in liver	0.3	0.3	0.5	-0.5	0.2	0.4	0.7	0.6
Zn content in liver	3.7	4.1	6.8	-1.7	-2.6	2.1	1.8	1.7
Bone: minimum diameter	0.4	0.8	1.5	0.1	-1.2	-0.6	-0.9	-1.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	-0.2	-0.3	-0.4	-0.4
Time in novel zone, hab. session 1	0.3	0.3	0.3	0.6	0.6	-0.5	-0.4	-0.5
Total zone transitions, hab. session 1	0.6	0.8	2.5	-1.6	0.2	0.5	0.7	0.8
Total locomotion distance, hab. session 1	1.8	2.5	3.8	1.5	0.4	-1.7	-1.9	-1.9
Locomotion velocity, hab. session 1	1.1	1.5	2.3	1.1	0.2	-1.3	-1.5	-1.5
Time in familiar zone, hab. session 2	0.9	0.9	2.2	-0.6	-1.5	1.0	0.7	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.6	0.1	0.8	-0.3	-0.1	-0.0
Total zone transitions, hab. session 2	2.8	3.6	8.2	-2.9	-1.1	1.7	1.7	1.7
Total locomotion distance, hab. session 2	0.6	0.8	1.5	0.3	-0.5	-0.8	-1.1	-1.2
Locomotion velocity, hab. session 2	0.8	1.1	2.3	0.5	-0.4	-1.0	-1.4	-1.5
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.5	-0.3	0.3	0.3	0.1
Novelty place preference	0.1	0.1	0.3	-0.6	-0.3	0.3	0.4	0.1
Time in novel zone, NPP test	0.3	0.3	0.5	-0.7	-0.4	0.5	0.6	0.3
Total zone transitions, NPP test	0.7	0.9	2.0	-1.4	-0.3	0.8	0.9	1.0
Total locomotion distance, NPP test	1.2	1.6	2.3	1.4	0.1	-1.3	-1.4	-1.5
Locomotion velocity, NPP test	1.6	2.2	3.0	1.6	0.5	-1.6	-1.7	-1.7
Intraocular pressure	0.5	0.7	1.4	-0.4	-0.2	0.8	1.0	1.2
Delta distance traveled before/after self-admin	3.2	3.5	7.7	-2.8	-1.1	1.8	1.6	1.6
Delta ambulatory time before/after self-admin	3.5	3.9	7.6	-2.8	-0.9	2.0	1.8	1.9
Parametrial fat weight	1.6	3.1	4.1	1.8	0.9	-1.9	-2.0	-1.9
Pavlov. Cond. lever latency	0.9	1.2	1.9	1.3	1.4	-1.1	-0.8	-0.8
Pavlov. Cond. magazine entry latency	2.1	2.7	4.9	-1.8	-2.2	1.6	1.2	1.2
Pavlov. Cond. change in total contacts	1.1	1.1	2.1	-1.2	-1.4	1.0	0.8	0.7
Pavlov. Cond. index score	2.1	2.6	4.8	-1.8	-2.2	1.6	1.2	1.1
Pavlov. Cond. latency score	2.0	2.6	4.6	-1.8	-2.1	1.6	1.2	1.2
Pavlov. Cond. lever contacts	0.7	0.8	2.0	-0.9	-1.4	0.8	0.6	0.6
Pavlov. Cond. magazine entry number	2.9	3.6	5.4	2.1	2.3	-1.9	-1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.5	0.6	1.2	-0.9	-0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	3.8	-1.7	-2.0	1.4	1.0	1.1
Pavlov. Cond. response bias	0.8	0.9	2.0	-1.1	-1.4	0.9	0.6	0.6
Pavlov. Cond. lever latency	14.5	19.5	30.6	4.8	5.5	-4.4	-3.6	-3.4
Pavlov. Cond. magazine entry latency	4.2	4.8	5.5	-2.2	-2.2	2.3	2.1	2.1
Pavlov. Cond. change in total contacts	12.8	17.7	25.5	-5.1	-4.8	4.1	3.5	3.3
Pavlov. Cond. index score	11.8	15.1	22.2	-4.2	-4.7	3.9	3.3	3.1
Pavlov. Cond. latency score	10.8	13.4	19.1	-4.0	-4.4	3.7	3.1	3.0
Pavlov. Cond. lever contacts	15.2	20.8	32.4	-5.0	-5.7	4.5	3.7	3.5
Pavlov. Cond. magazine entry number	7.6	9.3	11.0	3.3	3.1	-3.2	-2.8	-2.8
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.3	0.4	-0.4	-0.8	-1.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	10.7	13.6	21.0	-3.9	-4.6	3.7	3.1	2.9
Pavlov. Cond. response bias	15.9	21.7	31.8	-5.1	-5.6	4.6	3.9	3.7
Time in closed arm before self-admin	5.6	6.3	10.2	-3.2	-0.7	2.5	2.7	2.6
Time in closed arm after self-admin	0.3	0.3	1.2	0.3	1.1	-0.2	0.1	0.1
Time in open arm before self-admin	6.5	7.0	12.5	3.5	2.1	-2.7	-2.4	-2.4
Time in open arm after self-admin	0.5	0.6	1.2	1.1	-0.8	-0.4	-0.7	-0.7
Bone: periosteal estimation	0.4	0.9	3.6	-0.6	-1.9	0.6	0.3	0.0
Bone: periosteal perimeter	0.6	1.1	3.2	-1.0	-1.8	0.8	0.5	0.3
Bone: post-yield work	0.1	0.2	0.3	-0.2	-0.5	0.5	0.5	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.5	0.2	-0.1	-0.3	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.4	-0.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.7	-0.7	-0.8	0.7	0.2	0.5
Progressive ratio test 2 active lever presses	0.7	0.7	1.4	-1.1	-1.2	0.7	0.5	0.5
Progressive ratio test 2 breakpoint	0.6	0.7	1.5	-1.1	-1.2	0.7	0.5	0.5
Progressive ratio test 2 inactive lever presses	1.3	1.5	2.0	-1.4	-1.0	1.3	1.1	1.3
Incentive Sensitization - Responses	1.1	1.2	2.9	-1.0	-1.7	0.9	0.8	0.6
Incentive Sensitization - Breakpoint	1.2	1.2	2.5	-1.1	-1.6	1.0	0.9	0.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.9	0.7	-0.1	0.2	0.1
Progressive ratio	0.2	0.2	0.3	-0.4	0.1	0.4	0.5	0.6
Food seeking constrained by brief footshock	0.4	0.4	1.4	-0.9	-1.2	0.2	-0.0	-0.1
Seeking ratio, punishment vs. effort	0.4	0.4	1.4	-0.1	-1.2	-0.2	-0.5	-0.7
Retroperitoneal fat weight	6.4	20.9	29.3	4.4	1.6	-5.0	-5.4	-5.4
Reaction time number correct	0.8	1.1	2.0	-1.0	0.6	1.0	1.4	1.2
Reaction time mean minus median	0.3	0.4	1.4	-0.5	-1.2	0.6	0.2	0.2
Reaction time mean minus median AUC	0.8	1.1	1.5	-0.9	-1.2	1.2	0.9	0.9
Reaction time num false alarms	2.8	3.8	5.5	2.4	1.6	-2.0	-1.8	-1.9
Reaction time num false alarms AUC	1.5	2.0	3.7	1.9	1.3	-1.3	-1.2	-1.3
Reaction time trials correct on left	0.8	1.1	2.0	-1.0	0.6	1.0	1.4	1.2
Reaction time trials on left	0.8	1.1	2.0	-1.0	0.6	0.9	1.4	1.1
Reaction time mean	1.4	1.9	3.0	1.7	0.8	-1.3	-1.5	-1.4
Reaction time mean AUC	1.3	1.8	2.3	1.5	1.0	-1.3	-1.5	-1.3
Median of all reaction times	1.9	2.6	4.2	2.0	1.3	-1.5	-1.6	-1.5
Reaction time omissions	0.5	0.7	1.0	0.9	0.5	-0.9	-1.0	-0.9
Reaction time false alarm rate	2.4	3.4	5.8	2.4	1.0	-1.8	-1.9	-1.8
Reaction time premature initiation rate	0.7	0.9	3.7	0.2	-1.9	0.0	-0.6	-0.6
Reaction time premature initiations	0.4	0.6	2.3	-0.4	-1.5	0.7	0.4	0.2
Std. dev. reaction times	0.5	0.7	0.9	0.8	-0.8	-0.5	-1.0	-0.9
Reaction time trials completed	0.8	1.1	2.0	-1.0	0.6	0.9	1.4	1.1
Reaction time trials AUC	0.6	0.8	1.6	-0.8	0.5	0.8	1.3	1.0
Run reversals in cocaine runway, females	3.4	3.3	5.9	1.3	-0.1	-1.9	-2.4	-2.3
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.3	0.3	-0.0	-0.1	0.1
Latency to leave start box in cocaine runway	3.4	3.7	4.8	1.9	1.3	-2.1	-2.2	-2.0
Latency to leave start box in cocaine runway, F	3.7	4.0	5.7	1.9	0.9	-2.2	-2.4	-2.3
Latency to leave start box in cocaine runway, M	0.2	0.1	0.5	0.5	0.7	-0.2	-0.0	0.1
Std. dev. time between licks in bursts	0.6	0.8	2.6	0.4	-1.6	-0.2	-0.5	-0.8
Total sessions with >9 infusions	4.1	4.5	6.7	-2.6	-2.0	2.2	1.8	2.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.5	0.2	0.1	-0.2	0.1
Short access day 10 total inactive lever presses	0.2	0.2	0.5	0.7	0.6	-0.2	-0.0	-0.1
Short access day 1 total infusions	2.3	2.4	3.9	-1.7	-2.0	1.6	1.2	1.2
Short access day 10 total infusions	1.2	1.3	2.7	-1.5	-1.6	1.0	0.5	0.6
Short access total infusions	1.1	1.3	2.3	-1.4	-1.5	1.1	0.6	0.8
Short access day 1 locomotion	3.0	3.3	4.4	-1.6	-1.2	2.0	2.0	2.1
Short access day 10 total locomotion	0.1	0.1	0.3	-0.3	-0.5	0.2	0.3	0.1
Short access total locomotion	0.3	0.3	0.5	-0.7	-0.5	0.4	0.5	0.5
One hour access (0.3 mA shock)	1.6	1.9	3.3	-1.1	-1.8	1.5	1.2	1.1
Compulsive drug intake	0.3	0.3	0.4	0.5	0.5	0.3	0.6	0.6
One hour access (shock baseline)	1.2	1.4	3.1	-1.3	-1.7	1.1	0.8	0.7
Social response proportion	0.9	0.9	1.6	1.3	0.4	-0.9	-1.0	-1.1
Social responses	1.3	1.6	2.7	1.2	0.1	-1.2	-1.6	-1.6
Social time	1.4	1.9	4.7	0.8	2.2	-1.4	-1.1	-1.0
Soleus weight	1.1	3.2	4.6	2.1	-0.4	-1.7	-2.0	-2.1
Bone: stiffness	0.5	0.8	1.4	1.1	0.2	-0.9	-0.8	-1.2
Tibialis anterior weight	0.1	0.3	0.5	0.5	-0.7	-0.3	-0.5	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.5	-1.2	0.4	0.0	0.2	0.1
Time to tail flick, vehicle, after self-admin	4.1	4.4	6.5	-2.6	-1.8	2.1	1.9	2.0
Time to tail flick, test, before self-admin	0.5	0.5	1.7	-1.3	-0.8	0.1	-0.1	-0.1
Time to tail flick, test, after self-admin	0.4	0.4	0.8	-0.3	-0.9	-0.3	-0.6	-0.8
Delta time to tail flick, vehicle, before/after SA	2.1	2.1	2.8	-1.0	-1.6	1.7	1.3	1.6
Delta time to tail flick, test, before/after SA	0.4	0.4	0.7	0.8	0.4	-0.6	-0.6	-0.6
Tibia length	2.4	6.7	8.2	-2.6	-1.9	2.9	2.8	2.7
Ambulatory time before self-admin	1.3	1.3	2.0	1.4	1.3	-1.2	-0.8	-0.9
Ambulatory time after self-admin	1.1	1.2	2.5	-1.6	0.6	0.8	1.1	1.1
Bone: tissue strength	0.6	0.6	1.0	-0.5	0.8	0.5	0.9	1.0
Total heroin consumption	0.8	0.9	2.2	-1.5	-0.4	0.9	0.9	0.8
Bone: trabecular number	0.3	0.5	1.9	0.2	1.4	-0.5	-0.1	-0.0
Bone: trabecular spacing	0.9	1.1	1.4	-1.0	-1.2	1.1	1.1	1.0
Bone: trabecular thickness	0.3	0.4	0.5	0.3	0.6	-0.7	-0.7	-0.7
Bone: trabecular tissue density	2.8	4.0	6.3	1.8	0.8	-2.2	-2.3	-2.5
Water consumed over 24 hours	0.3	0.3	1.0	0.3	1.0	-0.6	-0.3	-0.3
Number of responses in last shaping day	0.1	0.1	0.3	0.2	-0.6	0.1	-0.1	-0.1